BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50000012 Clc1ccc2C(N3CCN(CC3)C(=O)Cc3cccnc3)c3ncccc3CCc2c1 InChI=1S/C25H25ClN4O/c26-21-7-8-22-20(16-21)6-5-19-4-2-10-28-24(19)25(22)30-13-11-29(12-14-30)23(31)15-18-3-1-9-27-17-18/h1-4,7-10,16-17,25H,5-6,11-15H2 GZUAAANARRVXPY-UHFFFAOYSA-N 50061465 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-3-yl-ethanone::CHEMBL334749 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >46000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50061465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50061465&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10432980 103957027 CHEMBL334749 ZINC27410846 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108107 CNC(=O)N1CCC(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3CCc3cc(Br)cnc23)CC1 InChI=1S/C27H33BrClN5O2/c1-30-27(36)34-8-6-18(7-9-34)14-24(35)32-10-12-33(13-11-32)26-23-5-4-22(29)16-19(23)2-3-20-15-21(28)17-31-25(20)26/h4-5,15-18,26H,2-3,6-14H2,1H3,(H,30,36) XWCMUCOWDZOIAS-UHFFFAOYSA-N 50063415 4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid methylamide::CHEMBL369047 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >35000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063415&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10507372 103958745 CHEMBL369047 ZINC27993074 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108129 Clc1ccc2C(N3CCN(CC3)C(=O)CN3C(=O)c4ccccc4C3=O)c3ncccc3CCc2c1 InChI=1S/C28H25ClN4O3/c29-20-9-10-21-19(16-20)8-7-18-4-3-11-30-25(18)26(21)32-14-12-31(13-15-32)24(34)17-33-27(35)22-5-1-2-6-23(22)28(33)36/h1-6,9-11,16,26H,7-8,12-15,17H2 ZLMHHZJUXGHHRE-UHFFFAOYSA-N 50063333 2-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-isoindole-1,3-dione::CHEMBL170295 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >40000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063333&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10720216 103958663 CHEMBL170295 ZINC28004915 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108134 CC(=O)C1CCC(CC1)C(=O)N1CCN(CC1)C1c2ccc(Cl)cc2CCc2cccnc12 InChI=1S/C27H32ClN3O2/c1-18(32)19-4-7-21(8-5-19)27(33)31-15-13-30(14-16-31)26-24-11-10-23(28)17-22(24)9-6-20-3-2-12-29-25(20)26/h2-3,10-12,17,19,21,26H,4-9,13-16H2,1H3 GYYWBOZTAUCCFO-UHFFFAOYSA-N 50063328 1-{4-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carbonyl]-cyclohexyl}-ethanone::CHEMBL422723 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >43000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063328&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 44382681 103958658 CHEMBL422723 ZINC28003124 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108148 CN1CCC(CC1)NC(=O)N1CCN(CC1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 InChI=1S/C25H31BrClN5O/c1-30-8-6-21(7-9-30)29-25(33)32-12-10-31(11-13-32)24-22-5-4-20(27)15-17(22)2-3-18-14-19(26)16-28-23(18)24/h4-5,14-16,21,24H,2-3,6-13H2,1H3,(H,29,33) DPUOYNLDETWCLN-UHFFFAOYSA-N 50063358 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-methyl-piperidin-4-yl)-amide::CHEMBL352653 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >38000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063358&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10506447 103958688 CHEMBL352653 ZINC27988854 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108149 Clc1ccc2C(N3CCN(CC3)C(=O)Cc3cccnc3)c3ncc(Br)cc3CCc2c1 InChI=1S/C25H24BrClN4O/c26-20-13-19-4-3-18-14-21(27)5-6-22(18)25(24(19)29-16-20)31-10-8-30(9-11-31)23(32)12-17-2-1-7-28-15-17/h1-2,5-7,13-16,25H,3-4,8-12H2 HJVVXXLJKNYHAR-UHFFFAOYSA-N 50063341 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-3-yl-ethanone::CHEMBL355453 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >10000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063341&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10815603 103958671 CHEMBL355453 ZINC27990662 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108158 N[C@@H](CO)C(=O)N1CCC(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3CCc3cc(Br)cnc23)CC1 InChI=1S/C28H35BrClN5O3/c29-21-14-20-2-1-19-15-22(30)3-4-23(19)27(26(20)32-16-21)34-11-9-33(10-12-34)25(37)13-18-5-7-35(8-6-18)28(38)24(31)17-36/h3-4,14-16,18,24,27,36H,1-2,5-13,17,31H2/t24-,27?/m0/s1 ZREREATVBFEIBH-BXXZMZEQSA-N 50063363 (S)-2-Amino-1-(4-{2-[4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-3-hydroxy-propan-1-one::CHEMBL170428 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >33000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063363&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 11801799 103958693 CHEMBL170428 ZINC28003012 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108165 Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccc(Br)cc3)c3ncccc3CCc2c1 InChI=1S/C26H25BrClN3O/c27-21-7-3-18(4-8-21)16-24(32)30-12-14-31(15-13-30)26-23-10-9-22(28)17-20(23)6-5-19-2-1-11-29-25(19)26/h1-4,7-11,17,26H,5-6,12-16H2 DNMVTJNZEPUZGW-UHFFFAOYSA-N 50063405 2-(4-Bromo-phenyl)-1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-ethanone::CHEMBL171443 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >50000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063405&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10529724 103958735 CHEMBL171443 ZINC27999188 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108166 CN1CCC(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3CCc3cc(Br)cnc23)CC1 InChI=1S/C26H32BrClN4O/c1-30-8-6-18(7-9-30)14-24(33)31-10-12-32(13-11-31)26-23-5-4-22(28)16-19(23)2-3-20-15-21(27)17-29-25(20)26/h4-5,15-18,26H,2-3,6-14H2,1H3 MMVLVRLMGLVJPZ-UHFFFAOYSA-N 50063368 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone::CHEMBL352525 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >38000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063368&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10816092 103958698 CHEMBL352525 ZINC13778944 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108167 CCCC[C@H]1CN(CCN1C(=O)Cc1cc[n+]([O-])cc1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12 InChI=1S/C29H32BrClN4O2/c1-2-3-4-25-19-33(13-14-35(25)27(36)15-20-9-11-34(37)12-10-20)29-26-8-7-24(31)17-21(26)5-6-22-16-23(30)18-32-28(22)29/h7-12,16-18,25,29H,2-6,13-15,19H2,1H3/t25-,29?/m0/s1 JAPZHGRPWASZKZ-GMMLNUAGSA-N 50063351 1-[(S)-4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-butyl-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone::CHEMBL366550 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >34200 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063351&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10769617 103958681 CHEMBL366550 ZINC27999501 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108177 Clc1ccc2C(N3CCN(CC3)C(=O)Nc3ccncc3)c3ncccc3CCc2c1 InChI=1S/C24H24ClN5O/c25-19-5-6-21-18(16-19)4-3-17-2-1-9-27-22(17)23(21)29-12-14-30(15-13-29)24(31)28-20-7-10-26-11-8-20/h1-2,5-11,16,23H,3-4,12-15H2,(H,26,28,31) VEXCGIFLHBOFMT-UHFFFAOYSA-N 50061490 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-4-ylamide::CHEMBL336597 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >40000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50061490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50061490&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10550770 103957052 CHEMBL336597 ZINC27414664 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108183 Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncc(Br)cc3CCc2c1 InChI=1S/C25H24BrClN4O/c26-20-14-19-2-1-18-15-21(27)3-4-22(18)25(24(19)29-16-20)31-11-9-30(10-12-31)23(32)13-17-5-7-28-8-6-17/h3-8,14-16,25H,1-2,9-13H2 CXHRDHMBLZINQP-UHFFFAOYSA-N 50063416 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone::CHEMBL368295 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >39000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063416&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10553781 103958746 CHEMBL368295 ZINC27995500 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108187 Clc1ccc2C(N3CCN(CC3)C(=O)C(c3ccccc3)c3ccccc3)c3ncccc3CCc2c1 InChI=1S/C32H30ClN3O/c33-27-15-16-28-26(22-27)14-13-25-12-7-17-34-30(25)31(28)35-18-20-36(21-19-35)32(37)29(23-8-3-1-4-9-23)24-10-5-2-6-11-24/h1-12,15-17,22,29,31H,13-14,18-21H2 FBAAQDIYOZAXRT-UHFFFAOYSA-N 50063454 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2,2-diphenyl-ethanone::CHEMBL171938 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >50000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063454&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 11799775 103958784 CHEMBL171938 ZINC27995296 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108196 Clc1ccc2C(N3CCN(CC3)C(=O)Nc3ccccc3)c3ncccc3CCc2c1 InChI=1S/C25H25ClN4O/c26-20-10-11-22-19(17-20)9-8-18-5-4-12-27-23(18)24(22)29-13-15-30(16-14-29)25(31)28-21-6-2-1-3-7-21/h1-7,10-12,17,24H,8-9,13-16H2,(H,28,31) KVNYSYUUCAMQCO-UHFFFAOYSA-N 50063345 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid phenylamide::CHEMBL354427 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >40000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063345&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10646414 103958675 CHEMBL354427 ZINC28007190 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108198 Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncccc3CCc2c1 InChI=1S/C25H25ClN4O/c26-21-5-6-22-20(17-21)4-3-19-2-1-9-28-24(19)25(22)30-14-12-29(13-15-30)23(31)16-18-7-10-27-11-8-18/h1-2,5-11,17,25H,3-4,12-16H2 QIVUVRPLLRMTDC-UHFFFAOYSA-N 50061441 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone::CHEMBL311310 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >46000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50061441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50061441&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9889061 103957003 CHEMBL311310 ZINC26266292 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108219 [O-][n+]1ccc(CC(=O)N2CCN(CC2)[C@H]2c3ccc(Cl)cc3CCc3cc(Br)cnc23)cc1 InChI=1S/C25H24BrClN4O2/c26-20-14-19-2-1-18-15-21(27)3-4-22(18)25(24(19)28-16-20)30-11-9-29(10-12-30)23(32)13-17-5-7-31(33)8-6-17/h3-8,14-16,25H,1-2,9-13H2/t25-/m0/s1 UHGZCRVPTZSYOB-VWLOTQADSA-N 50063372 1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone::CHEMBL305798 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >76000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063372&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9871581 103958702 CHEMBL305798 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108224 Clc1ccc2C(N3CCN(CC3)C(=O)Nc3ccccn3)c3ncccc3CCc2c1 InChI=1S/C24H24ClN5O/c25-19-8-9-20-18(16-19)7-6-17-4-3-11-27-22(17)23(20)29-12-14-30(15-13-29)24(31)28-21-5-1-2-10-26-21/h1-5,8-11,16,23H,6-7,12-15H2,(H,26,28,31) OSMCTDZWSBGSAO-UHFFFAOYSA-N 50061486 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-2-ylamide::CHEMBL336370 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >46000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50061486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50061486&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10694111 103957048 CHEMBL336370 ZINC27331086 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50107988 Clc1ccc2C(N3CCN(CC3)C(=O)Nc3cccnc3)c3ncc(Br)cc3CCc2c1 InChI=1S/C24H23BrClN5O/c25-18-12-17-4-3-16-13-19(26)5-6-21(16)23(22(17)28-14-18)30-8-10-31(11-9-30)24(32)29-20-2-1-7-27-15-20/h1-2,5-7,12-15,23H,3-4,8-11H2,(H,29,32) LAMMGSMTEGESJZ-UHFFFAOYSA-N 50063331 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-3-ylamide::CHEMBL425133 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >10000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063331&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10649434 103958661 CHEMBL425133 ZINC13779005 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50107996 NC(=O)N1CCC(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3CCc3cc(Br)cnc23)CC1 InChI=1S/C26H31BrClN5O2/c27-20-14-19-2-1-18-15-21(28)3-4-22(18)25(24(19)30-16-20)32-11-9-31(10-12-32)23(34)13-17-5-7-33(8-6-17)26(29)35/h3-4,14-17,25H,1-2,5-13H2,(H2,29,35) QXMXLXMWARQWNN-UHFFFAOYSA-N 14456 4-N-carboxamidopiperidinylacetyl 2::4-[2-(4-{6-bromo-13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl}piperazin-1-yl)-2-oxoethyl]piperidine-1-carboxamide::CHEMBL144031 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >35000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14456&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9959504 46514796 CHEMBL144031 ZINC27551240 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108001 CN1CCC(CC(=O)N2CCN(CC2)[C@@H]2c3ccc(Cl)cc3CCc3cc(Br)cnc23)CC1 InChI=1S/C26H32BrClN4O/c1-30-8-6-18(7-9-30)14-24(33)31-10-12-32(13-11-31)26-23-5-4-22(28)16-19(23)2-3-20-15-21(27)17-29-25(20)26/h4-5,15-18,26H,2-3,6-14H2,1H3/t26-/m1/s1 MMVLVRLMGLVJPZ-AREMUKBSSA-N 50063342 1-[4-((R)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone::CHEMBL354809 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >38000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063342&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10721003 103958672 CHEMBL354809 ZINC13778942 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108014 CN(C)c1ccc(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3CCc3cccnc23)cc1 InChI=1S/C28H31ClN4O/c1-31(2)24-10-5-20(6-11-24)18-26(34)32-14-16-33(17-15-32)28-25-12-9-23(29)19-22(25)8-7-21-4-3-13-30-27(21)28/h3-6,9-13,19,28H,7-8,14-18H2,1-2H3 BXMOASUHWDVRIC-UHFFFAOYSA-N 50063355 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(4-dimethylamino-phenyl)-ethanone::CHEMBL172397 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus 42000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063355&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10743164 103958685 CHEMBL172397 ZINC27991949 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108016 [O-][n+]1ccc(CC(=O)N2CCN(CC2)[C@@H]2c3ccc(Cl)cc3CCc3cc(Br)cnc23)cc1 InChI=1S/C25H24BrClN4O2/c26-20-14-19-2-1-18-15-21(27)3-4-22(18)25(24(19)28-16-20)30-11-9-29(10-12-30)23(32)13-17-5-7-31(33)8-6-17/h3-8,14-16,25H,1-2,9-13H2/t25-/m1/s1 UHGZCRVPTZSYOB-RUZDIDTESA-N 50063359 1-[4-((R)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone::CHEMBL432911 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >38000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063359&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10578069 103958689 CHEMBL432911 ZINC26251140 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108017 CN1CCCC(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3CCc3cc(Br)cnc23)C1 InChI=1S/C26H32BrClN4O/c1-30-8-2-3-18(17-30)13-24(33)31-9-11-32(12-10-31)26-23-7-6-22(28)15-19(23)4-5-20-14-21(27)16-29-25(20)26/h6-7,14-16,18,26H,2-5,8-13,17H2,1H3 PUHMESLJVPPQNX-UHFFFAOYSA-N 50063360 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-3-yl)-ethanone::CHEMBL172387 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >38000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063360&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10768592 103958690 CHEMBL172387 ZINC13778971 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108031 [O-][n+]1ccc(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3CCc3cc(Br)cnc23)cc1 InChI=1S/C25H24BrClN4O2/c26-20-14-19-2-1-18-15-21(27)3-4-22(18)25(24(19)28-16-20)30-11-9-29(10-12-30)23(32)13-17-5-7-31(33)8-6-17/h3-8,14-16,25H,1-2,9-13H2 UHGZCRVPTZSYOB-UHFFFAOYSA-N 50063366 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone::CHEMBL171265 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >38000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063366&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 9914869 103958696 CHEMBL171265 ZINC26251147 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108037 Clc1ccc2C(N3CCN(CC3)C(=O)CC3CCNCC3)c3ncc(Br)cc3CCc2c1 InChI=1S/C25H30BrClN4O/c26-20-14-19-2-1-18-15-21(27)3-4-22(18)25(24(19)29-16-20)31-11-9-30(10-12-31)23(32)13-17-5-7-28-8-6-17/h3-4,14-17,25,28H,1-2,5-13H2 VOCBHZWNUHMROR-UHFFFAOYSA-N 50063373 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-piperidin-4-yl-ethanone::CHEMBL352918 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >38000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063373&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10768220 103958703 CHEMBL352918 ZINC13778955 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108045 Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccccn3)c3ncccc3CCc2c1 InChI=1S/C25H25ClN4O/c26-20-8-9-22-19(16-20)7-6-18-4-3-11-28-24(18)25(22)30-14-12-29(13-15-30)23(31)17-21-5-1-2-10-27-21/h1-5,8-11,16,25H,6-7,12-15,17H2 KKXWFFNNTODCTJ-UHFFFAOYSA-N 50061495 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-2-yl-ethanone::CHEMBL341393 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >46000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50061495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50061495&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10788891 103957057 CHEMBL341393 ZINC27411959 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108049 CC(=O)N1CCC(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3CCc3cc(Br)cnc23)CC1 InChI=1S/C27H32BrClN4O2/c1-18(34)31-8-6-19(7-9-31)14-25(35)32-10-12-33(13-11-32)27-24-5-4-23(29)16-20(24)2-3-21-15-22(28)17-30-26(21)27/h4-5,15-17,19,27H,2-3,6-14H2,1H3 SEHLSBMUTCCSCL-UHFFFAOYSA-N 50063378 2-(1-Acetyl-piperidin-4-yl)-1-[4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-ethanone::CHEMBL354747 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >34000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063378&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10745444 103958708 CHEMBL354747 ZINC27989310 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108050 CCCNC(=O)N1CCC(CC(=O)N2CCN(CC2)C2c3ccc(Cl)cc3CCc3cc(Br)cnc23)CC1 InChI=1S/C29H37BrClN5O2/c1-2-9-32-29(38)36-10-7-20(8-11-36)16-26(37)34-12-14-35(15-13-34)28-25-6-5-24(31)18-21(25)3-4-22-17-23(30)19-33-27(22)28/h5-6,17-20,28H,2-4,7-16H2,1H3,(H,32,38) NGSYGMDRTBHHQI-UHFFFAOYSA-N 50063362 4-{2-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid propylamide::CHEMBL172097 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >33000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063362&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10769930 103958692 CHEMBL172097 ZINC27991449 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108051 CN1CCC(CC(=O)N2CCN(CC2)[C@H]2c3ccc(Cl)cc3CCc3cc(Br)cnc23)CC1 InChI=1S/C26H32BrClN4O/c1-30-8-6-18(7-9-30)14-24(33)31-10-12-32(13-11-31)26-23-5-4-22(28)16-19(23)2-3-20-15-21(27)17-29-25(20)26/h4-5,15-18,26H,2-3,6-14H2,1H3/t26-/m0/s1 MMVLVRLMGLVJPZ-SANMLTNESA-N 50063379 1-[4-((S)-3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone::CHEMBL305431 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >38000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063379&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 11800388 103958709 CHEMBL305431 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108060 Clc1ccc2C(N3CCN(CC3)C(=O)\C=C\c3cccnc3)c3ncccc3CCc2c1 InChI=1S/C26H25ClN4O/c27-22-8-9-23-21(17-22)7-6-20-4-2-12-29-25(20)26(23)31-15-13-30(14-16-31)24(32)10-5-19-3-1-11-28-18-19/h1-5,8-12,17-18,26H,6-7,13-16H2/b10-5+ PGFAXHIRKZWFBW-BJMVGYQFSA-N 50063383 (E)-1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-3-pyridin-3-yl-propenone::CHEMBL169966 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >50000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063383&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 10789480 103958713 CHEMBL169966 ZINC27989427 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631 50108087 Clc1ccc2C(N3CCN(CC3)C(=O)Nc3cccnc3)c3ncccc3CCc2c1 InChI=1S/C24H24ClN5O/c25-19-7-8-21-18(15-19)6-5-17-3-1-10-27-22(17)23(21)29-11-13-30(14-12-29)24(31)28-20-4-2-9-26-16-20/h1-4,7-10,15-16,23H,5-6,11-14H2,(H,28,31) UYAWMLCIDQNGSJ-UHFFFAOYSA-N 50061484 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid pyridin-3-ylamide::CHEMBL130362 Dimer of Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Rattus norvegicus >46000 ChEMBL 10.1021/jm970462w 10.7270/Q2M61JDN 9526562 Mallams, AK; Rossman, RR; Doll, RJ; Girijavallabhan, VM; Ganguly, AK; Petrin, J; Wang, L; Patton, R; Bishop, WR; Carr, DM; Kirschmeier, P; Catino, JJ; Bryant, MS; Chen, KJ; Korfmacher, WA; Nardo, C; Wang, S; Nomeir, AA; Lin, CC; Li, Z; Chen, J; Lee, S; Dell, J; Lipari, P; Liu, M Schering-Plough Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50061484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000153&target=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50061484&enzyme=Dimer+of+Protein+farnesyltransferase%2Fgeranylgeranyltransferase+type-1+subunit+alpha&column=ki&startPg=0&Increment=50&submit=Search 11797067 103957046 CHEMBL130362 ZINC27330676 1 MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV 1D8D,1D8E,1FPP,1FT1,1FT2,1JCR,1JCS,1KZO,1KZP,1N4P,1N4Q,1N4R,1N4S,1N94,1S64,1SA5,1TN7,1TN8,1TNB,1TNO,1TNU,1TNY,1TNZ,1X81,3DPY,3E30,3E32,3E33,3E34,3EU5,3EUV,3PZ4,4GTM,4GTO,4GTP,4GTQ,4GTR,8E9E Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha FNTA_RAT Q04631