BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 19840 NS(=O)(=O)c1cc2C=C(CN3CCOCC3)N(c3cccc(O)c3)S(=O)(=O)c2s1 InChI=1S/C17H19N3O6S3/c18-28(22,23)16-9-12-8-14(11-19-4-6-26-7-5-19)20(29(24,25)17(12)27-16)13-2-1-3-15(21)10-13/h1-3,8-10,21H,4-7,11H2,(H2,18,22,23) PZLYYZPXSSNGJS-UHFFFAOYSA-N 11390 2-(3-Hydroxyphenyl)-3-(4-morpholinylmethyl)-2H-thieno-[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide::2-(3-hydroxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::AL-6619::Compound 17p1 Carbonic anhydrase 4 Homo sapiens 4.25 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11390&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search INQ 1I91 4369172 46511932 DB03262 ZINC12503368 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19841 COc1cccc(c1)N1C(CN2CCOCC2)=Cc2cc(sc2S1(=O)=O)S(N)(=O)=O InChI=1S/C18H21N3O6S3/c1-26-16-4-2-3-14(11-16)21-15(12-20-5-7-27-8-6-20)9-13-10-17(29(19,22)23)28-18(13)30(21,24)25/h2-4,9-11H,5-8,12H2,1H3,(H2,19,22,23) XSUAVPPTKHUTDX-UHFFFAOYSA-N 11391 2-(3-Methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno-[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide::2-(3-methoxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::AL-6629::Compound 17k1 Carbonic anhydrase 4 Homo sapiens 7.41 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11391&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search INL 1I8Z 4369171 46511933 DB03598 ZINC12503776 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19842 CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1 HCRKCZRJWPKOAR-JTQLQIEISA-N 10885 (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::(R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-E)-1,2-thiazine-6-sulfonamide 1,1-dioxide::AL-4862::Azopt::Brinzolamide (BRZ)::brinzolamide Carbonic anhydrase 4 Homo sapiens 45.3 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10885&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BZ1 3ZNC,4M2V,4M2R,6BBS 68844 46511455 3176 DB01194 6797 C07760 ZINC03953037 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19843 NS(=O)(=O)c1cc2C=CN(CCN3CCOCC3)S(=O)(=O)c2s1 InChI=1S/C12H17N3O5S3/c13-22(16,17)11-9-10-1-2-15(23(18,19)12(10)21-11)4-3-14-5-7-20-8-6-14/h1-2,9H,3-8H2,(H2,13,16,17) KRJXNTFQVBUWBY-UHFFFAOYSA-N 11394 2-[2-(4-Morpholinyl)ethyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride::2-[2-(morpholin-4-yl)ethyl]-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride::2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 2::Compound 5b Carbonic anhydrase 4 Homo sapiens 15.2 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11394&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 9909805 46511936 ZINC14947963 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19844 CCCNCCN1C=Cc2cc(sc2S1(=O)=O)S(N)(=O)=O InChI=1S/C11H17N3O4S3/c1-2-4-13-5-7-14-6-3-9-8-10(20(12,15)16)19-11(9)21(14,17)18/h3,6,8,13H,2,4-5,7H2,1H3,(H2,12,15,16) LGHKMXPOEQXMNC-UHFFFAOYSA-N 11396 1,1-dioxo-2-[2-(propylamino)ethyl]-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride::2-[2-(Propylamino)ethyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride::2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 4::Compound 5d Carbonic anhydrase 4 Homo sapiens 73.6 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11396&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 19434097 46511938 ZINC14947969 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19845 CN1C(CN2CCOCC2)=Cc2cc(sc2S1(=O)=O)S(N)(=O)=O InChI=1S/C12H17N3O5S3/c1-14-10(8-15-2-4-20-5-3-15)6-9-7-11(22(13,16)17)21-12(9)23(14,18)19/h6-7H,2-5,8H2,1H3,(H2,13,16,17) LNCRXOFOQXBUDR-UHFFFAOYSA-N 11397 2-Methyl-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride::2-methyl-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride::2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 6::Comound 17a1 Carbonic anhydrase 4 Homo sapiens 16.9 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11397&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 19434034 46511939 ZINC14947972 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19846 COCCN(CC=C)CC1=Cc2cc(sc2S(=O)(=O)N1C)S(N)(=O)=O InChI=1S/C14H21N3O5S3/c1-4-5-17(6-7-22-3)10-12-8-11-9-13(24(15,18)19)23-14(11)25(20,21)16(12)2/h4,8-9H,1,5-7,10H2,2-3H3,(H2,15,18,19) NKKBOUBMVAAJAF-UHFFFAOYSA-N 11399 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 9::3-[[N-(2-Methoxyethyl)-N-(2-propenyl)amino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride::3-{[(2-methoxyethyl)(prop-2-en-1-yl)amino]methyl}-2-methyl-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride::Compound 17a7 Carbonic anhydrase 4 Homo sapiens 16.9 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11399&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 23645551 46511941 ZINC14947978 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19847 NS(=O)(=O)c1cc2C=C(CN3CCOCC3)N(CC=C)S(=O)(=O)c2s1 InChI=1S/C14H19N3O5S3/c1-2-3-17-12(10-16-4-6-22-7-5-16)8-11-9-13(24(15,18)19)23-14(11)25(17,20)21/h2,8-9H,1,3-7,10H2,(H2,15,18,19) KDCJIHNQDVKCTE-UHFFFAOYSA-N 11411 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 18::3-(morpholin-4-ylmethyl)-1,1-dioxo-2-(prop-2-en-1-yl)-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::3-[(4-Morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide::Compound 17e1 Carbonic anhydrase 4 Homo sapiens 23.3 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11411&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 19434092 46511952 ZINC14948003 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19848 NS(=O)(=O)c1cc2C=C(CN3CCOCC3)N(C3CCCCC3)S(=O)(=O)c2s1 InChI=1S/C17H25N3O5S3/c18-27(21,22)16-11-13-10-15(12-19-6-8-25-9-7-19)20(14-4-2-1-3-5-14)28(23,24)17(13)26-16/h10-11,14H,1-9,12H2,(H2,18,21,22) HZWDJRHOANOYLB-UHFFFAOYSA-N 11413 2-Cyclohexyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide::2-cyclohexyl-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 20::Compound 17g1 Carbonic anhydrase 4 Homo sapiens 49.5 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11413&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 23645556 46511954 ZINC14948009 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19849 COCCN1C(CN2CCOCC2)=Cc2cc(sc2S1(=O)=O)S(N)(=O)=O InChI=1S/C14H21N3O6S3/c1-22-5-4-17-12(10-16-2-6-23-7-3-16)8-11-9-13(25(15,18)19)24-14(11)26(17,20)21/h8-9H,2-7,10H2,1H3,(H2,15,18,19) MSYLNLLWLRHXBJ-UHFFFAOYSA-N 11414 2-(2-Methoxyethyl)-3-[(4-morpholinyl)methyl]-2H-thieno-[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide::2-(2-methoxyethyl)-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 21::Compound 17h1 Carbonic anhydrase 4 Homo sapiens 39.9 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11414&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 19434082 46511955 ZINC14948012 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19850 COCCCN1C(CN2CCOCC2)=Cc2cc(sc2S1(=O)=O)S(N)(=O)=O InChI=1S/C15H23N3O6S3/c1-23-6-2-3-18-13(11-17-4-7-24-8-5-17)9-12-10-14(26(16,19)20)25-15(12)27(18,21)22/h9-10H,2-8,11H2,1H3,(H2,16,19,20) VHKDBWJRZPKBFG-UHFFFAOYSA-N 11416 2-(3-Methoxypropyl)-3-[(4-morpholinyl)methyl]-2H-thieno-[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride::2-(3-methoxypropyl)-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride::2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 23::Compound 17i1 Carbonic anhydrase 4 Homo sapiens 23.6 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11416&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 19434075 46511957 ZINC40741235 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19851 COc1ccc(CN2C(CN3CCOCC3)=Cc3cc(sc3S2(=O)=O)S(N)(=O)=O)cc1 InChI=1S/C19H23N3O6S3/c1-27-17-4-2-14(3-5-17)12-22-16(13-21-6-8-28-9-7-21)10-15-11-18(30(20,23)24)29-19(15)31(22,25)26/h2-5,10-11H,6-9,12-13H2,1H3,(H2,20,23,24) KXCBICPXDWRGSX-UHFFFAOYSA-N 11419 2-[(4-Methoxyphenyl)methyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride::2-[(4-methoxyphenyl)methyl]-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride::2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 26::Compound 17j1 Carbonic anhydrase 4 Homo sapiens 5.45 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11419&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 19434023 46511960 ZINC14948021 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19852 COc1ccc(cc1OC)N1C(CN2CCOCC2)=Cc2cc(sc2S1(=O)=O)S(N)(=O)=O InChI=1S/C19H23N3O7S3/c1-27-16-4-3-14(11-17(16)28-2)22-15(12-21-5-7-29-8-6-21)9-13-10-18(31(20,23)24)30-19(13)32(22,25)26/h3-4,9-11H,5-8,12H2,1-2H3,(H2,20,23,24) BWXPYQBMTBKNFK-UHFFFAOYSA-N 11422 2-(3,4-Dimethoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride::2-(3,4-dimethoxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride::2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 29::Compound 17m1 Carbonic anhydrase 4 Homo sapiens 10.1 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11422&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 23645564 46511962 ZINC14948026 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19853 NS(=O)(=O)c1cc2C=C(CN3CCOCC3)N(c3ccc(cc3)N3CCOCC3)S(=O)(=O)c2s1 InChI=1S/C21H26N4O6S3/c22-33(26,27)20-14-16-13-19(15-23-5-9-30-10-6-23)25(34(28,29)21(16)32-20)18-3-1-17(2-4-18)24-7-11-31-12-8-24/h1-4,13-14H,5-12,15H2,(H2,22,26,27) UTEITKVDXIZOAO-UHFFFAOYSA-N 11423 2-[(4-Morpholinyl)phenyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride::2-[4-(morpholin-4-yl)phenyl]-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride::2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 30::Compound 17n1 Carbonic anhydrase 4 Homo sapiens 8.65 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11423&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 19434012 46511963 ZINC14948029 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19854 NS(=O)(=O)c1cc2C=C(CNCC#C)N(c3cccc(O)c3)S(=O)(=O)c2s1 InChI=1S/C16H15N3O5S3/c1-2-6-18-10-13-7-11-8-15(26(17,21)22)25-16(11)27(23,24)19(13)12-4-3-5-14(20)9-12/h1,3-5,7-9,18,20H,6,10H2,(H2,17,21,22) BISUIZWGJFAJFB-UHFFFAOYSA-N 11425 2-(3-Hydroxyphenyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride::2-(3-hydroxyphenyl)-1,1-dioxo-3-[(prop-2-yn-1-ylamino)methyl]-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide hydrochloride::2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 33::Compound 17p8 Carbonic anhydrase 4 Homo sapiens 6.25 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11425&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 19434109 46509365 ZINC14948035 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19855 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 IAVUPMFITXYVAF-XPUUQOCRSA-N 10884 (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide::Dorzolamide (DRZ)::Dorzolamide (DZA) Carbonic anhydrase 4 Homo sapiens 32.0 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10884&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ETS 4M2W,4M2U,4K13,3FW3,6BC9,1CIL 5284549 46511454 4702 DB00869 6810 C06969 ZINC01530621 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19856 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 17.5 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19857 CC(=O)N=c1sc(nn1C)S(N)(=O)=O InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) FLOSMHQXBMRNHR-UHFFFAOYSA-N 10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid_4100::sulfonamide 2 Carbonic anhydrase 4 Homo sapiens 205 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10881&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search MZM 4K0Z,4YHA,5KU6,1BZM,5C8I,3DAZ,3DCS 4100 46511451 CHEMBL288100 6828 ZINC12503151 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 19858 Cc1ccc(cc1)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C9H10N4O4S3/c1-6-2-4-7(5-3-6)20(16,17)13-8-11-12-9(18-8)19(10,14)15/h2-5H,1H3,(H,11,13)(H2,10,14,15) FNICBGZPBTURDA-UHFFFAOYSA-N 11427 2-N-(4-methylbenzene)-1,3,4-thiadiazole-2,5-disulfonamido::5-{[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide::CHEMBL108380::Methylbenzolamide Carbonic anhydrase 4 Homo sapiens 5.6 Curated from the literature by BindingDB 10.1016/s0968-0896(00)00026-2 10.7270/Q23B5XC0 10882008 aid1796686 Chen, HH; Gross, S; Liao, J; McLaughlin, M; Dean, T; Sly, WS; May, JA Alcon Research Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11427&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 394904 46511966 CHEMBL108380 ZINC05579280 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 23480 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 Curated from the literature by BindingDB 10.1021/jm060807n 10.7270/Q24T6GKT 17125255 aid1796980 Winum, JY; Temperini, C; El Cheikh, K; Innocenti, A; Vullo, D; Ciattini, S; Montero, JL; Scozzafava, A; Supuran, CT Universite Montpellier II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 23481 CC(=O)N=c1sc(nn1C)S(N)(=O)=O InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) FLOSMHQXBMRNHR-UHFFFAOYSA-N 10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid_4100::sulfonamide 2 Carbonic anhydrase 4 Homo sapiens 6200 Curated from the literature by BindingDB 10.1021/jm060807n 10.7270/Q24T6GKT 17125255 aid1796980 Winum, JY; Temperini, C; El Cheikh, K; Innocenti, A; Vullo, D; Ciattini, S; Montero, JL; Scozzafava, A; Supuran, CT Universite Montpellier II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10881&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search MZM 4K0Z,4YHA,5KU6,1BZM,5C8I,3DAZ,3DCS 4100 46511451 CHEMBL288100 6828 ZINC12503151 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 23482 CCOc1ccc2nc(sc2c1)S(N)(=O)=O InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) OUZWUKMCLIBBOG-UHFFFAOYSA-N 10882 6-ethoxy-1,3-benzothiazole-2-sulfonamide::CHEMBL18::Ethamide::Ethoxazolamide::Ethoxzolamide::Ethoxzolamide (EZA)::Ethoxzolamide, EZM::Sulfonamide, 3::US10172837, Ethoxyzolamide::sulfonamide 3 Carbonic anhydrase 4 Homo sapiens 93 Curated from the literature by BindingDB 10.1021/jm060807n 10.7270/Q24T6GKT 17125255 aid1796980 Winum, JY; Temperini, C; El Cheikh, K; Innocenti, A; Vullo, D; Ciattini, S; Montero, JL; Scozzafava, A; Supuran, CT Universite Montpellier II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10882&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EZL 3DD0,5JN9,3CAJ,3MDZ,6BCC,3DCW,6QL2,5TT3,6MWI 3295 46511452 101096 CHEMBL18 DB00311 6814 ZINC00056721 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 23483 NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) GJQPMPFPNINLKP-UHFFFAOYSA-N 10883 4,5-dichlorobenzene-1,3-disulfonamide::CHEMBL17::Dichlorophenamide::Dichlorophenamide (DCP)::Dichlorophenamide, DCP::Sulfonamide, 4::US10172837, Dichlorphenamide::sulfonamide 4 Carbonic anhydrase 4 Homo sapiens 15000 Curated from the literature by BindingDB 10.1021/jm060807n 10.7270/Q24T6GKT 17125255 aid1796980 Winum, JY; Temperini, C; El Cheikh, K; Innocenti, A; Vullo, D; Ciattini, S; Montero, JL; Scozzafava, A; Supuran, CT Universite Montpellier II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10883&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search I7A 2POU 3038 46511453 101085 CHEMBL17 DB01144 6807 C07459 ZINC00896918 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 23484 CCN[C@@H]1C[C@@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m1/s1 IAVUPMFITXYVAF-HTRCEHHLSA-N 13054 (2R,4R)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide::Dorzolamide, DZA::sulfonamide 5 Carbonic anhydrase 4 Homo sapiens 8500 Curated from the literature by BindingDB 10.1021/jm060807n 10.7270/Q24T6GKT 17125255 aid1796980 Winum, JY; Temperini, C; El Cheikh, K; Innocenti, A; Vullo, D; Ciattini, S; Montero, JL; Scozzafava, A; Supuran, CT Universite Montpellier II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13054&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 92087 46513474 ZINC01530620 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 23485 CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 KJADKKWYZYXHBB-XBWDGYHZSA-N 10887 Sulfamate 7::Topiramate (TPM)::US11535599, Example topiramate::[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate Carbonic anhydrase 4 Homo sapiens 4900 Curated from the literature by BindingDB 10.1021/jm060807n 10.7270/Q24T6GKT 17125255 aid1796980 Winum, JY; Temperini, C; El Cheikh, K; Innocenti, A; Vullo, D; Ciattini, S; Montero, JL; Scozzafava, A; Supuran, CT Universite Montpellier II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10887&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TOR 3LXE,3HKU,5JNA 5284627 46511457 63631 DB00273 6849 C07502 ZINC01530804 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 23486 CC1(C)O[C@@H]2CO[C@@]3(CNS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H22N2O7S/c1-10(2)18-7-5-17-12(6-14-22(13,15)16)9(8(7)19-10)20-11(3,4)21-12/h7-9,14H,5-6H2,1-4H3,(H2,13,15,16)/t7-,8-,9+,12+/m1/s1 NQRKKQKMTGLNOZ-XBWDGYHZSA-N 13055 CHEMBL283695::Compound 8::Topiramate Sulfamide Analogue 8::amino-N-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}sulfonamide Carbonic anhydrase 4 Homo sapiens 941 Curated from the literature by BindingDB 10.1021/jm060807n 10.7270/Q24T6GKT 17125255 aid1796980 Winum, JY; Temperini, C; El Cheikh, K; Innocenti, A; Vullo, D; Ciattini, S; Montero, JL; Scozzafava, A; Supuran, CT Universite Montpellier II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13055&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search B19 2H15 10712038 46513475 CHEMBL283695 ZINC13612331 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49482 [F-] InChI=1S/FH/h1H/p-1 KRHYYFGTRYWZRS-UHFFFAOYSA-M 26978 BDBM50098540::CHEMBL1528::CHEMBL1644027::F-::fluoride::fluoride ion Carbonic anhydrase 4 Homo sapiens 70000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26978&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search F 6WO7,5EVC,6WOA,3MBA,6WO8,2WVG,4KKL,4KK8,7TN4,2XMC,2Q9P,6QDY,6YTT,3VRS,4F60,7KK8,6JIM,1E6A,1LH5,6RI8,6RI6,6RI4,6RIL,6RIK,6RII,1BS3,7T0Y,5NAI,6EVH,5A43,6VCM,6VCL,6LL8,6B2B,6B2A,6B2D,6B24,6BQO,5VEJ,2QFP,5KBN,2LH5,5KOM,3HQ2,6WOB,7TJ1,7F9V,2WSL,2AUU,2AU6,2AU9,6A24,4X30,4ENC,4ENB,4ENA,5K91,1T5G,6BX4,6BX5,6VCK,2AKZ,5NKQ,7KKB,7KKA,3PPM,5XB2,3SSV,4CEX,1NEL,2UVN,2HAW,5XD5,4JB4,4X00,6HOO,2DQZ,4Q3K,6D0J,6D0K,6D0N,7SP3,4KJQ,6WOI,4EN5,4GOA,2Z5Z 28179 57298688 64428 CHEMBL1644027CHEMBL1528CHEMBL1362 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49483 [Cl-] InChI=1S/ClH/h1H/p-1 VEXZGXHMUGYJMC-UHFFFAOYSA-M 26979 CHEMBL69710::Cl-::POTASSIUM CHLORIDE::SODIUM CHLORIDE::chloride::chloride ion Carbonic anhydrase 4 Homo sapiens 90000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26979&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CL 1W23,5QA9,5QA8,5QAF,5QAC,5QAO,7SUU,5QAX,5QAZ,3B3A,3B36,5QA5,5QA4,1Y6P,1Y6Q,1Y6G,5ETO,5ETX,5ETP,1K6X,1K6J,1K6I,1K6E,5QAE,5QAD,5QAG,1XV5,1XV8,5QAB,1K63,5QAM,5QAL,5QAU,5QAT,5QAW,5QAV,5QAQ,5QAP,5QAR,5QAY,7LNP,7LN9,7LN8,3LTD,3LTA,3LTC,3LTB,3LT9,3LT8,6O6Q,6BJD,6TW6,6TWP,6TWT,2NP0,4LCB,4LC8,4LC6,2ZDP,6Y6J,6Y65,6Y67,6PUJ,6PUG,6PUA,6PUC,6PUB,6PUX,6PU9,6PU1,1YL0,5Y2I,5Y2U,5Y2X,5Y2Y,1YLF,1GYH,1GYE,1GYW,1GYT,6WOP,6J1T,6J1Q,6J1P,6J1C,6J1B,6J1A,3GCF,6WO7,5FCZ,5FCU,5FCP,3GC2,1IHU,1IHA,1IHN,3QVM,3QVJ,3QVR,3QVP,3QVQ,3KWE,3KWD,3KWC,3KWK,3KW0,3LBB,3N65,3N64,3N66,3N61,3N60,3N63,3N62,4QNN,4QNL,4QNJ,4QNI,3N6X,3N6H,5CAJ,5CAI,5CAE,3AJN,3AJV,3AJX,5YXG,3U1W,7SGY,7SGX,1Z4U,7SGW,7SGV,6JKX,6JKZ,2BU3,2Q7B,2Q7C,2Q7X,2BUP,6K91,2BUJ,2BUF,2Q78,7A62,6DJ5,4LKT,8BFC,4Q4P,4Q4O,4Q4F,3NXS,3NXQ,6ZOU,6ZOA,4BG9,4BG8,4BGU,3RDK,3RDR,4C10,4C13,7R9C,4C1K,4C1L,4C1M,4NSV,7O3I,1F74,1F7T,1F7L,1F7B,8DTE,6F62,8AGH,8AGO,1EU8,6GFS,3WXT,3WXU,1SLT,4DNZ,4DNJ,4IMS,4IMU,4IMF,2QYC,7QIB,1Z47,4IM2,4IM3,1H87,1H80,6PH0,6PH1,8BGN,8J0V,8J0U,8J0Z,8J0X,8J0Y,6Z9A,6Z93,6IK6,4GB2,4AUV,1PPI,5SJT,5SJR,4GBU,4GBT,4GBM,4GBL,4GBN,4GBI,4GBK,4GBF,4GBC,2DXE,2AEE,2AER,4AUX,4YGD,4YGE,4YGF,4YGC,5N38,1FM0,1XDA,1FMV,1FMA,6Q4S,2O24,6Q4P,3VWI,2FJ9,246L,2FJ1,2FJN,3W6X,3W6A,1HBU,1HBM,1HBO,1HBN,1HBA,4TMZ,7ZSM,7BMX,7BMZ,7BMW,7BMP,7ZSH,6Q42,7ZSF,6Q40,7ZSG,7C5P,3I7R,3JW2,1O6B,1O6S,1O6T,1O6Z,6I58,6O6N,6I5X,6I5S,6I5B,6I5C,6I5D,3O8M,6TW5,5NYW,5NYK,5NYM,5NYE,7DBG,7DBA,5NY7,6RVM,4W97,4W91,6TWO,4W93,3BD1,6TWN,199L,6CYA,6CYZ,6CY6,7F6Q,7F6S,7F6T,7F6K,7F6E,5HNE,5HNO,5HNP,4M8L,4M8O,3Q2I,6QJ6,4M8K,7ZX2,3EH7,6QJX,6QJW,6QJA,5KK0,3O3L,5KKE,5KKI,5KKK,5KKJ,5KKY,1KAZ,1KAY,1KAX,2IT9,6Y6Y,2D4K,3ITD,6Y6A,2ITZ,7R31,4WMH,160L,4WMV,7R3L,7R3T,7R3Q,5O5M,4WM1,4WM2,4WM3,4WM4,4WM5,1W07,1W08,5EV8,5EVC,4LZM,4LZD,3OG3,3OGH,3PEI,1VDF,5QJA,5QJN,5QJT,1VDX,5QJZ,4ARA,4ARW,4ARU,3VRY,3VRZ,3VRC,2VSY,6DD4,1XMK,7LQY,6E03,3ZN5,3ZN4,3ZN6,6E0A,7LQ1,6E0V,3ZNV,3ZNJ,1NRX,5E5H,1NR5,3IWW,3C8Q,4W78,6NS0,6NSV,6NSX,6THA,6THE,4LXU,4A8E,2CF7,2CFV,3BPK,3BPR,1YYV,3TOZ,4JKX,4JKH,4JKD,4JKC,4JKB,4JKA,4JK9,4JK8,4JK7,4JK6,4JK5,6AEA,3UQ9,2X98,3UQU,4OL9,7WN7,3H4X,2YO3,2YO0,2YO1,2YOI,2YOL,2YOR,2YOZ,6WZ3,6WZ2,6WZ1,6WZ7,7CRL,7CRI,7CRJ,7CRK,7CRT,7CRS,7CRX,7CRY,6WZC,6WZA,6WZP,6WZU,8DV3,7EKK,7N3Z,7N3D,6T68,6T6O,6T6C,6T6G,7BD0,6YWO,4B2X,4B2W,4B2M,4B2H,4B2J,4B2K,4B2B,4B2C,2W5E,2W5B,7LWE,4ZJM,4ZJK,3HBV,3HBU,3HBN,6W08,3HB2,5VWM,5VWV,3K6M,3K6Q,2V6G,6MPT,6MPX,8I17,3NW8,3NW9,6LCN,3NWB,3NWD,3NWE,3NWN,6WOD,6WOF,6WOA,3MBY,3MBJ,3MBH,3MBD,3MB4,1UJ4,1UJ5,1UJ6,6WO8,6WO9,5FCD,2B4O,5FCC,3CQY,3CQO,3CQB,3CQE,6UAO,1ENN,6SET,3WMQ,3WMP,1SAW,3AUK,8AJP,4IXQ,4IXR,4IXT,4IXW,7B6B,2QTS,4IX8,2QT6,3AU2,3GJD,6URY,6UR3,5T5X,5T5P,5T5T,5T5L,4F78,4F71,2YIH,2YIL,3GJ2,2YIO,4GYZ,4GYL,4GYN,4GYO,4GYF,4GYB,5LHV,7WGT,7WGD,4UI0,6FUA,4UI1,6FU7,7BJB,1E4W,7BJD,1E42,7PTZ,7XO8,7XO9,3FF3,3FFC,4UIJ,5U16,5U1H,5U1O,5U1A,5U1Z,5U1Q,1HYZ,1HYU,1HYV,6L9Z,4CIE,3JZE,3JZD,3JZT,8G1Y,4QU6,7EFT,7S0U,2EEX,7ODH,7ODN,3OFW,7ODA,7ODG,7RDP,7OD0,1MOX,1MOG,1MOF,4QNZ,2Z2N,2Z2O,2Z2K,2Z2W,2OVZ,2OVX,2OV2,4MKK,4MKU,4MKS,7UKT,7UKP,7UKB,7V2T,6CLZ,3EE6,6D3M,3EEE,6D30,5HEZ,7P20,7P2B,7P2U,7P2T,7P2Z,4CPR,4CPW,2PMP,2PMU,2PMF,3PH5,3PH6,1TDR,8IBL,6DYF,6DYI,3VY5,3VY6,3VY7,2HC1,2HCF,4U87,5XZJ,4U6N,4U6Y,1QQN,7PHZ,7ZW2,3I36,2I58,2I54,2I55,2I52,3I3J,2DWW,3I3R,2I5X,5CX7,6NH1,6NH2,6NH3,6NH4,6NH5,6NH6,6NH8,6NHF,6NHS,6KCD,6KCB,5E97,5E98,6KC6,1S4N,1S4O,7JM6,7JM7,7JMQ,3NFZ,6MTH,7ETL,6MTZ,6MTW,6MTU,2V2Z,2V2H,6MT8,5OM1,5OM6,5OM5,5OM8,5OMY,5OMX,5OMC,5OMB,5OMI,6AHH,6AHS,6AHY,3UNH,3UNF,4ULX,4OS4,6V75,6V74,6V76,6V70,6V73,6V72,4OSF,4OSG,4V82,4U8W,3GYP,8ER7,5M56,4D4F,143L,1U16,4Y14,2C5W,2C5U,4Y1D,3U04,3DIB,3DIC,6VI5,3U0X,2XXV,2XXW,3DI8,3DI9,3DI7,3U0E,5JFF,5JFY,5JFU,5JFP,3G7U,3G7T,3G71,7UXZ,5VZ7,5VZ9,5VZG,5VZE,5VZC,5VZB,5VZH,7NPX,7NPG,7NPB,7NPA,7NPI,118L,7NP2,7NP8,1R85,1R87,1R86,5DKA,1R89,5DKX,2GLP,2GLV,2GLM,2GLL,4PJE,1R8K,3NBU,7MEL,4ZH5,3MOZ,3MOR,3MOG,1CPU,7QNQ,2WVO,7P11,7KT8,7KT9,7KT7,7KT4,7KT5,7KT3,7KT0,7KT1,7D4B,7KTN,7KTJ,7KTH,7KTG,7KTE,5WDJ,3CZ0,3CZ1,3CZ2,3CZ4,5WGI,5V0F,5V0W,5V0R,5V0X,5V0Z,5MY9,1JDB,5V01,1ZAN,4H1Z,6M8Y,6ZQ1,1JD7,3A6K,6UIE,6UIO,6M83,3RV4,5B5E,5B5Q,5B5U,1PJK,5B53 312 57298689 64428 CHEMBL19429CHEMBL69710 2339 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49484 [Br-] InChI=1S/BrH/h1H/p-1 CPELXLSAUQHCOX-UHFFFAOYSA-M 26980 Br-::CHEMBL1644030::CHEMBL1644694::bromide::bromide ion Carbonic anhydrase 4 Homo sapiens 90000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26980&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BR 1Y63,1XVC,1K6E,1K63,5Y24,2X42,2X40,2X41,1IHR,1XOK,2O29,7U5Q,1XMT,7WNL,7WNK,4B29,5VWW,3FFQ,2HC0,3I32,2V2Q,2V2V,5VZ4,4G6V,4KK6,6DRQ,2HTL,2HTK,4U9S,4U9Y,7PSF,4PM3,4BQO,1L0Z,3R1D,3R1E,1RER,5C0E,3DD7,2XMD,5C0T,5C0U,7QIK,2J3S,7M54,1QUI,1M3D,4YGJ,2HYP,4GP3,7TA2,4TM3,4TM1,4TM4,4DX8,4ICH,1OVL,3STV,6R62,5NGW,7L1E,2Q44,2IUO,2VR4,3ZOZ,8OKM,3GW6,6DDA,6DV1,7KK8,6VHX,6VHZ,6VHQ,6VHT,6VHU,6VHW,3MNG,5WC8,6FAQ,2FSX,7OP6,7OP7,1GED,1L1G,7Z57,5D5F,4DR9,6FN6,3FYS,4FBM,6EZ1,5AV2,6EZY,5AV4,1N8B,1VP6,3ZRG,8C7X,2B4G,3NEG,6LWY,6ZXX,7B9A,7KM7,7KM9,6G35,6HPD,6HPQ,6EQQ,6TQD,1IJV,4IO1,6I3A,3C9A,7ROO,2VQU,2VQT,7RDE,2XQ3,1EAO,5MNU,7QTX,3F2F,4TPY,4TPU,6CNU,5EXG,2VF3,3I18,6FZ6,3U6X,2WPF,4JRW,5JSP,5JSR,6H0A,7CUD,2J19,2J18,5H11,7DW5,1N9K,3Q4W,3LLP,7O21,7KK9,7T0H,7T0Y,1GQB,1GQP,5DSF,3SVD,3SVE,7QWI,6HSW,5M76,3V08,7L32,1IMX,3KLC,4R6C,6SMA,6GIV,4GAO,7RLM,1D2V,5HMJ,4WHI,2VPS,2VPM,5AV1,5GXY,5GXZ,1NUF,1NUD,2CIV,2CIZ,4LU4,6T36,6T38,2XPN,3MPR,6HTK,4F8L,4HC6,5S9S,7XBY,5U2P,1MHK,7P5T,2HLF,3DLU,4POD,4POC,4N6C,2WQ1,2WQ4,2XQG,3C51,4HH5,4HHQ,4HHO,3FPG,3FPF,3FPE,3FPJ,2EWF,4MY6,3LBO,2O2I,5G2A,1TO3,2XNT,5JTC,2QKI,7NBV,2AWD,2WDU,7O9R,5WV3,5MWK,3M3G,2HT4,2HT2,2HT3,2EZ0,7LGT,3LM7,7O5I,7O5T,7O5W,7O5V,7O5R,2ZC1,3BBZ,5LWQ,4JYE,4JYD,5LXR,5VEH,1F08,2QFE,4IFD,5NBX,5M65,8FC0,4QKO,3ONB,3ONC,6TS9,2BYD,6LZX,6LZY,6GJT,6RRV,2VOT,3F0O,3F0P,6GL4,6FY8,1Q3O,7KKR,6NLH,4H5B,2FPR,5L7F,1DOC,1DOE,2R4G,1RAZ,6M9G,5DZ6,7F9U,7F9V,8SA7,6S5H,7AS0,7O45,6BPA,4JXI,5FEA,1SR4,4R86,6R2N,3V6Q,5GXF,3O7O,6Y3A,5C5V,2X3H,5FHR,2J6L,6GKI,5SMJ,5FKR,367D,2FE8,4N8O,1D07,2HEK,4LS4,4LSI,4LSH,4LSE,4LSF,5SWA,3HNO,3A3K,6XQP,5EFH,1ROC,6SUT,7QJL,3TU8,3TUU,3LD5,6BZQ,6BZT,4CO6,5IL0,2FKK,3S8Y,2XHY,3DY9,3DYE,6GVA,5AMT,4ABL,8CIR,3Q17,1P2X,1YIY,1YIZ,1LZ9,1D7W,7QFK,4GIO,1PWX,6HTM,5S9W,5S9V,5S9U,5S9T,5S9Z,5S9Y,5S9X,7CXD,2DGL,7STU,3LZ3,6NX2,5LXY,6JU1,2VMF,6TF2,6TFE,6TFF,1WY0,4PWC,3F6O,4UJA,5U79,5U7C,5U7B,5U7A,2H34,5FKT,4KVH,4XY8,6PKY,2HI8,3R47,5OGX,6V9D,4HMK,7OW7,4MTM,3LEP,6PDK,7ECD,5I5P,6H42,6H45,1OSY,4ACK,2OJT,3LPH,2NTI,4M5X,6ARZ,3GGQ,6GBG,5SV6,3A0B,7M3R,1AZF,6QN3,7ZD4,7VTI,2YKF,7OLO,4C8U,5SCO,2FCV,4MO1,1KJL,1W99,7YUG,3MD9,4AZI,2VL4,7PD1,4LQK,2V6Q,8FHJ,4OWH,4OWB,5C9E,1EG6,3F75,7VGT,7VGU,7Q14,7OM3,8B3W,7SWS,4BWO,7Z00,5IUX,3UPT,6RO3,6MEI,4QH1,6P1M,6BXR,4K4R,1IZ8,6IYX,5FKS,6HM7,3G4Z,1JHD,6OMI,4Q7O,3LQL,3LQG,4P98,4P9P,4P9O,5OPP,4Q1U,1CIJ,8ADQ,4YD4,7KKB,7KKA,1FJ2,3EKI,5EUS,5AWX,2P3H,5FKQ,4ERR,4ER6,5CYQ,6FT9,7QQ7,7BEN,2G2P,7OCN,3X41,3X42,1MGY,1XEQ,7PEP,7REF,6W0S,7NUP,8ARC,7OLQ,7OLT,7OLK,7OLL,7OLM,4H3S,5LFT,6ZWI,6ZWE,4NKU,4NKT,4Y9F,4Y9C,4NSG,6RNU,4M5W,4KCO,4KCM,2CIX,2CIY,6YOD,6YOE,6YOB,6YOC,5YER,6Z6R,6Z6D,4R34,6Z8G,2RC3,2RC7,7O8Z,7O8Y,7O87,7FIB,3QBK,4Q2A,1F5M,3K9U,1HD2,3EJZ,3EJY,3O31,3USH,4B0O,3SSK,5MJ6,3WCR,5T7A,5GU5,5SAS,5SA3,5SA2,5SA1,5SA0,2VJX,5N7L,3CXM,3F59,5U82,5U83,5FQE,4DEY,6KTZ,4OXS,5IWO,5IWN,6ZVO,4PA3,5MPW,3BIY,1L9M,4QRY,3D7R,6K5I,6K5F,6K5D,6K5A,7A0H,3SRE,3SRG,2WBK,2WB9,6XKE,6S29,4B4P,1N0R,6AQK,6JL0,6KW0,4IL9,5SK7,5N2A,6QML,4W6T,6TII,6AD7,6AD8,6ADB,6ADA,3GUD,4P4G,5D5C,7QW3,4PA4,5ZQU,6D0G,8BAO,7PGO,3I4U,6TB7,6F01,4BRP,7KQ9,5GY1,5GY0,6XTD,3FLH,8CX9,4YEM,4Z0T,6KU2,8D87,4PA9,7TMD,3G99,5DAV,2WHR,2WH6,2VO5,6XAW,5M92,4C46,4KAH,5N6X,4XJF,4XJG,5Y9S,6YMN,4FBS,6K6J,4GOY,4GOV,5AHZ,3IVN,3M4H,6QGL,1N11,4GP0 259 57298690 64428 CHEMBL11685CHEMBL1644030CHEMBL1644694 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49485 [I-] InChI=1S/HI/h1H/p-1 XMBWDFGMSWQBCA-UHFFFAOYSA-M 26981 CHEMBL1644695::I-::POTASSIUM IODIDE::iodide::iodide ion Carbonic anhydrase 4 Homo sapiens 80000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26981&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IDO 1ARX,1ARY,1B2K,1CMK,1CQW,1F09,1F3M,1GW9,1GWA,1GWD,1GWG,1GZA,1HC0,1HC9,1HUH,1J2J,1J99,1JWG,1LKR,1MOU,1MOV,1MXI,1N5M,1NJK,1NZB,1OJ5,1OUQ,1OVL,1OXS,1OXU,1OXV,1OXX,1PVH,1Q0T,1Q3U,1Q3V,1Q8C,1QI9,1QK0,1RLJ,1RRK,1RS0,1RTK,1S1M,1S6V,1SD5,1T1F,1T6C,1TUK,1U12,1U65,1UJK,1UTX,1V1F,1V1G,1VAT,1VKC,1VKO,1W2Z,1W50,1W51,1WC7,1WCB,1WCV,1WNW,1WY4,1XB7,1XC6,1XP4,1Y0S,1YDO,1YKU,1YRI,1ZCR,1ZVV,2A0N,2AF6,2AK4,2ANV,2ANX,2AQW,2ARL,2B9X,2BIV,2BMK,2C3N,2C3Q,2C3V,2CIW,2CJ6,2CJ7,2CJ8,2CKK,2CKL,2D8O,2D8P,2D8W,2D91,2D98,2DFB,2DFC,2DGM,2EDA,2EDC,2EIX,2ES4,2ESV,2EWJ,2FDS,2FWE,2FWF,2FWH,2GGQ,2GJM,2GQ2,2GS7,2GZB,2H9A,2HA0,2HA7,2HIB,2HQ6,2HRA,2I05,2I06,2I1W,2I8E,2ID1,2IPS,2IWK,2IZD,2IZQ,2J7P,2JJS,2NOO,2NQX,2O2B,2O86,2OF0,2OGS,2OGT,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2OJV,2OYY,2P4M,2PFI,2PUM,2Q2L,2QC5,2QCH,2QHX,2QPK,2QQT,2R5L,2REZ,2V8I,2VA5,2VA6,2VA7,2VBV,2VGZ,2VMA,2VUW,2YV7,2Z5Z,3BAS,3BCA,3BS9,3BV9,3CGP,3CJQ,3CT9,3D11,3DHX,3DY6,3E3T,3E7A,3EGV,3F6Q,3FNL 30165 57298691 64428 CHEMBL185537CHEMBL1644695 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49486 [N-]=C=O InChI=1S/CNO/c2-1-3/q-1 IQPQWNKOIGAROB-UHFFFAOYSA-N 26982 CHEMBL1644696::CNO(-1)::cyanate Carbonic anhydrase 4 Homo sapiens 610000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26982&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 105034 57298692 48819 CHEMBL1644696 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49487 [N-]=C=S InChI=1S/CNS/c2-1-3/q-1 ZBKFYXZXZJPWNQ-UHFFFAOYSA-N 26983 CHEMBL1644028::SCN(-1)::Thiocyanate::cyanosulfanide::sodium thiocyanate Carbonic anhydrase 4 Homo sapiens 39000000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26983&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SCN 3B3C,3B3S,3B3V,3B3W,3B3T,3B35,1YLK,3GCL,3GCK,3GCJ,3GC1,4IMQ,4IMZ,4IMO,4YGK,1DNU,1DNW,5HNS,6QJU,5LIH,3VRK,6THV,2YOA,6JPT,2TCI,6LCO,3CQX,1KGS,6L9T,4RJD,2EHA,3ERA,3ERH,3ERI,5LE2,6KV0,3R15,4NPE,5JQ4,3CGM,2OLZ,6BTP,6BTQ,6BTO,6KY7,6YJI,3N8F,4NYW,2FA2,7QKN,4L82,3TGY,3ZXN,7U4I,7U4J,1GXW,2YAS,3N72,6D9N,2VR6,2VR7,2VR8,5QJ0,4A9K,2YLC,3QZ0,5VP3,2F49,4GV5,3BFF,3VH9,2EB5,2EB4,6D2J,6D2V,6DXX,5OLG,4JPS,3MNP,2WWP,3R5O,3R55,7Q4A,6EOL,6EOG,7Z0N,2PA5,1UTH,3S4F,7TOM,6H1F,4Z9S,5GLS,3TL2,6X94,2OM1,6BSL,4GM7,4WND,5N4I,1Y81,4ETQ,6A6Y,7B9C,7DE5,5OVV,3WAW,2UYE,2UYF,8BB2,8BB3,8BB5,4EB0,3GA5,6MAN,6GS3,2AV1,3CIX,6X8O,4MSF,2PUM,7O21,6YHQ,5OUF,2Y27,2RFL,3HUF,6XOC,6EVB,6EV8,6EV5,3O5O,3BXI,3BXH,4OD7,4R0Q,4NPD,4AUP,4V0C,4ZG6,4ZGA,6W35,5U28,7OIH,4KSZ,7RMS,4A6U,3UCM,7OQ6,2XES,5MZG,5KO0,7P4O,3BOS,5D3D,7TIA,7TIZ,5I83,4PDY,2A9V,5LSY,5LSR,5LSS,2PCU,2ABB,5OBW,5OBU,3Q85,6Y2H,4OEK,6A4Y,3HK0,3U65,7RMR,5HBB,6NWL,4UE0,4E7U,3NKN,3NKO,3NKM,3NKR,3NKP,3NKQ,5I86,6SSS,5EG8,6DU7,4A75,3UBA,7Z3L,7Z3K,1LCN,4HON,6EBX,6EBZ,4UMO,6CCF,3EVX,5YII,5MVV,2H11,5NHT,7ASZ,4FGE,4FGD,3LNY,5LT7,3DSO,3SXV,2A5V,3V6Q,7YZ8,6Y9C,3O71,5FYP,6ZJ7,6ZJ4,6FHN,2QRB,6J9J,1XPP,6RQX,7PB6,6E5B,5M7M,6MR1,1RTQ,5IJQ,2XR9,4ZAY,4ZAX,4ZAZ,4ZAW,4ZAV,4ZAL,4ZAN,4ZAG,4ZAF,5EUX,1TEW,4Y55,3FKJ,5JJY,6QZY,6LF7,5OHY,5OHS,5W53,3SE2,7VLJ,3C70,4XG1,3QF1,1LOK,7ARP,4AB1,3QK2,1SQ4,7QF6,4YB5,2RKY,7YYJ,4L37,2VXH,1BHC,2E9E,2CA2,4OCF,6WU5,4P0C,8ING,5O1X,5A13,7R58,6NUB,6NU5,5E2G,6TF7,6KFB,2WYK,6XPH,7BR1,3PVZ,3R4X,4Y7P,5W4M,2GJM,2WL1,6HAV,6HAE,2OGB,3ETW,3PY4,5K9H,2J51,6LDQ,6XFU,3B7I,4VHB,4QJQ,6U9L,1SP3,3FAQ,6R0K,2FNO,6RZJ,6RZI,6RZL,3V48,2IPS,1XQ9,3H8D,2QPK,3WAY,3WAX,4F36,7AHB,3LNX,6XSN,7OMY,7OMX,7OMZ,7OMW,7OMV,7OMF,5ULH,5LT6,4PCG,6P1E,2JLP,6L2J,7MSQ,6S0F,3IBD,7JTO,5LSZ,5LS7,7L8L,7L8R,6SJ9,2QQT,3FCL,3FCI,3FCF,7S7R,2EFB,7Q63,3I6N,2V51,4D7Z,1U4H,6VDB,5DLW,5DLV,5DLT,5DLB,6LK1,3NOF,3FNL,7ANU,4FUM,4FUO,4FUN,6B8W,5EBE,1LG6,6ZW1,5AE4,6SP8,6SP5,5V8G,3LY5,5TJ7,3KXL,3P1C,3P1D,3P1E,4CRZ,3H79,6XHT,6XHR,6XHS,7AWE,5FA2,7QL7,3BFE,2FAM,1H51,5NRK,6D1P,3EGR,7P0K,4F7O,7ZQX,5AQA,6TC2,7WYJ,4EFR,4EFQ,4EFP,3G5O,4HEI,7XXK,2JFL,7OO2,5ZGS,5M0D,5M0E,5M0M,3UEN,6M7E,5M0S,4PAB,4PAW,6FIE,5AQ8,7OXV,7KOV,1GMK,4CS0,1SXS,2GX9,3SRX,3VEH,1Y7H,3ZZO,6Y9D,4DO8,6I4K,6I4J,6I4I,6I4M,6I4L,6I4G,6I4E,6I4D,3KXI,6ZN1,4TSQ,3POX,3POQ,7PGE,2V3U,5MHP,2WUF,2WUG,2WUD,2WUE,3WAV,2JIL,4TXO,6B6U,6DS9,5K0P,6KUM,3I3N,7P4J,6FHC,3TJQ,5BU6,5BUO,5BUW,5BUX,2OCS,4KAF,2O9S,5LKA,3MNO,3P31,2UV2,5JLB 9322 57298693 48819 CHEMBL1644028 4529 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49488 [C-]#N InChI=1S/CN/c1-2/q-1 XFXPMWWXUTWYJX-UHFFFAOYSA-N 26984 CHEMBL1644697::CN(-1)::cyanide::iminomethanide Carbonic anhydrase 4 Homo sapiens 770000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26984&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CYN 1NGK,1DNW,4U8U,2GL3,2GLN,1B0B,4KKJ,1TH3,4NL5,2HYS,7KBY,1HLM,7ATJ,1N2N,7VUW,1GX7,1H9Y,3ZOL,2X66,2X67,2X68,3MN0,1EBT,1ITH,1S61,1S69,3FYI,2GKM,4QUR,1MD2,7VVR,7P46,3MM6,3MM3,3MM2,3MMO,3I39,1S56,1LHT,1LH3,7O25,7O26,4FNI,4ODC,1UVX,1SI4,1ECN,2JHO,3X2Q,6COI,3I04,5V3T,5V3U,5V3V,3MYN,3MYM,3QM8,6WH6,1LT0,6R3Y,2LH3,2LHB,1EQD,1ARU,1ARV,1ARW,3ZJM,3ZJL,3ZJN,3ZJI,3ZJH,3ZJJ,3ZJR,6TD7,3WFE,1E08,3PT8,1JL7,1JL6,7DVU,2GHD,2GHK,1ABY,3QGP,4L4E,4L4G,1YMC,1IOP,2QRW,1RTE,5C6E,6CII,5SYL,5OHE,5OHF,7KBZ,1DLY,1IX3,2OIF,1D7W,1FHB,2E9E,2E7E,6RPD,6RPE,3PCL,3PCM,6KFC,2W3H,2WY4,1E2R,6NBL,3BJP,3AYZ,3AYX,1EOA,2OJV,2E39,3FAQ,1HFE,2D0U,4L2M,2IG3,2CMM,3NN2,1DW1,4M06,2GKN,5WMX,5WMW,5WMV,5WMU,3VOL,7W3E,1OR4,7O9L,1O1I,3NP1,4C9L,4C9O,1EMY,2EFB,1EBC,4L4D,4L4F,3DAF,7ZOS,3BA2,2CIY,3VLJ,3VLI,3AG4,3KUO,3KUN,1H1X,2FAL,2G3H,5NRP,5WK9,1SHR,5M34,5M3B,5WP2,4GEP,1O76,6CXU,6CXV,6E35,1NQP,4B3W,1D5L,1DGG,2V3N,1UX8,7KQT,2JIR,5AZQ,1GJQ,7O1O,7O1S,7O1T,1I5T,2QBM,2QBO,5M2Q,5M29 5975 57298694 18407 CHEMBL1644697 C00177 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49489 [N-]=[N+]=[N-] InChI=1S/N3/c1-3-2/q-1 IVRMZWNICZWHMI-UHFFFAOYSA-N 26985 2-triaza-1,2-diyne::CHEMBL79455::CHEMBL89295::N3(-1)::azide Carbonic anhydrase 4 Homo sapiens 65100000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26985&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZI 1PPJ,1PP9,5NYW,4JKX,7WNL,7WNK,4QU0,4ESJ,3PHM,2VHB,4PJY,3MOO,1TH2,2BBR,1JKV,1UGB,1ZWN,3LJ9,3BGO,2B5Z,4QTY,1NXD,3N7U,4BFG,7QHM,3JTM,6QKN,2IUO,1MNG,1RSV,1RSR,1U06,1OCZ,2WWN,2EIE,2OZP,1S6A,1LKP,2WJP,4QUQ,4QUB,4QUG,4QUE,4QUJ,4QUH,4QUL,4QU9,7W6W,3SWJ,2RG9,3AH9,8GVM,2FHX,1KOP,1W6W,3PG8,3PG9,2VQ1,1T0R,5T30,4OQC,4EB2,6VOB,3DKE,3HWL,1PHM,3S7W,7THQ,7THN,4YTG,4YTB,1QWL,8BXX,3E7A,3E7B,3ABW,1ZYT,6BG0,6BG4,6BGQ,6BGR,6BGK,5O4Q,1ASQ,6T3O,4PR8,1EKJ,4RBM,3UCN,4POE,3MLL,2WQY,5L6X,5FQU,1IVJ,2BGA,2BG6,4NAJ,3L74,1VR8,4JYY,3QM9,2BL1,3P24,2A4T,6BFO,6BFL,6BFJ,6T9W,6T9X,4C5P,3VVK,3ZJO,3ZJS,2NAD,2CUU,3G3X,3G3W,3G3V,3QGU,3D2O,2BFK,2BFL,2BFZ,1RAY,2H88,4N7T,6R2U,3E15,6T81,2CK3,1CVA,1A4E,5OHH,2WSR,6UBE,5MBA,5Z85,5Z84,5Z86,2JLM,7ARZ,3LO1,3P9F,3P9O,1QWM,6BDV,1FS9,5A12,6D4B,6D4C,4JAC,5DN9,3CWB,4FSK,4XYB,2TSB,6M0A,2J8M,2J8R,3C61,5ZCO,5ZCP,5ZCQ,4PUV,4JQG,4NB7,1OS2,4WZV,3BAX,2Y68,1AZI,3HFU,6ALV,4Y8G,4Y8H,4Y84,2MHR,5IN2,1SZ6,3L75,3B4P,3RC3,5EDF,2FBW,1AVM,1AVN,6NKC,4OTX,3FUC,1YAZ,3BAW,1I3E,1OQ4,1NEG,7O8C,3GAS,5IBP,3DWQ,2D23,2IVB,2VUO,1UGF,4JIJ,5JDT,1ONK,3MIH,3MIC,3MIE,3MID,2JJ2,2JJ1,2O5M,1ISC,6VP2,3SID,3L2X,3ZWH,1SXZ,1OPM,2X5O,2GSD,5AG2,2E86,1BJE,1VNC,2VI7,7NOX,6TB6,3DHG,2JIZ,1ZLZ,2BCP,1S8N,5MUN,7RNZ,2ZO5,1SWM,2IVG,2A06 33558 57298695 30105 CHEMBL79455CHEMBL89295 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49490 OC([O-])=O InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1 BVKZGUZCCUSVTD-UHFFFAOYSA-M 26986 CHEMBL363707::HCO3-::SODIUM BICARBONATE::bicarbonate ion::hydrogen carbonate Carbonic anhydrase 4 Homo sapiens 6600000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26986&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BCT 3E2W,3V83,7R30,2JF9,2ILM,6YW0,6YW1,4ZJY,4IXQ,4IXR,4IXZ,4URF,2HC9,7PHO,4V82,3RV4,5B5E,7ADY,3G8C,4YRW,1ZTJ,3Q6J,5LHK,6OAD,7ZB0,7RF1,1HCB,6ABU,6VCF,6W1O,6W1V,6W1T,6W1R,6W1P,6W1Q,3HCN,3HCO,4WAK,6KAC,6KAF,6KAD,7PIN,7PIW,7PI5,7PI0,6KLZ,3U7C,7EVQ,5MX2,5B66,5LBC,2PIJ,4YSW,4Z9V,4FBY,7JRD,4LHD,5DRK,7RP9,7RPC,7RPB,7RPA,7RPF,7RPE,7RPD,5N4I,6WQP,4C7Z,4C7Y,1F9B,8GVC,6I33,6I35,6AC1,3OW5,6KM2,7ZAZ,7EGL,1S5L,4YTY,4YTZ,2A8D,7N8O,5ZJW,5TG6,5TG7,5TG4,5TG5,5OUF,6LV1,6LV2,6LV4,6LV6,6LV8,4PJ0,1YQW,3GLR,6A7X,5BXI,4DKI,4RY9,5NTD,5NTH,4H83,4WHQ,4WHP,4WHO,7YQ2,7YQ7,7ZZ3,7ZZ5,7EQU,3V7P,1OAO,2IST,2AXT,4K0X,4K0W,7COU,2BGS,4YUU,7RCV,3OU9,1VRG,7WK7,6G55,7N88,5D4O,5D4P,5O3Q,5O3R,3WDR,5HBC,3H02,5CRY,6DUX,1LI0,4ELS,1ZML,5ZAS,7OUI,5LAT,5TIS,4US8,4US9,4USA,2J7Y,2J7X,7ADR,6KM0,6KM1,8EZ5,3SXM,3SXK,4RVY,4RVA,5KAF,5KAI,6N7F,7A24,7A23,4ZLA,1CAM,1CAH,6YP7,7KCT,8EQM,8F4J,8F4K,8F4H,8F4I,8F4F,8F4G,8F4D,8F4C,4XZ5,3VBI,3VBK,3VBM,3VBL,4EML,7D1P,7D1T,7D1U,7D1N,6SC3,7KBL,4KLR,7EDA,4LHC,3DTB,2QD2,4YBO,7Y7A,6DIK,7ZB1,6F89,2FDA,7PNK,6SC0,4I4Z,4I42,7ZYY,6KI1,5V2C,5DEI,7D2J,4CLL,5WS5,5WS6,5GTI,3AN1,6DHH,6DHO,6DHF,6DHG,6DHE,6DHP,1V67,3H8G,3H8F,4C80,3WAE,1DXK,2ESF,3AX7,3AX9,4Z7J,1ZSJ,1ZSK,6W1U,1CL1,7O9N,6MYP,6J40,3AM9,3AMZ,7Y5E,2D3I,2VVB,4ZI6,6SJ0,7AIZ,7PE4,6UJ6,6XR0,7VD5,5ZZN,7C5V,7C5X,1LGD,2E3T,4PBU,7NHO,4MV9,4MV3,1BVT,7CJI,7CJJ,3WU2,2E1Q,6J3Y,6J3Z,4Q2H,6WJ6,6IM0,5CXK,7RF8,7RF5,7RF4,7RF7,7RF6,7RF3,7RF2,1BIC,5E79,5E7C,4A1T,6AJU,4UB8,4UB6,4V62,8EPZ,1JF8,1QRL,1QRE,4DUR,5ADT,5ADR,5ADS,5ADQ,6SQX,3E3F,3E3I,3VM1,4QRO,5LBE,5LBF,5LBB,3JCU,5FBK,5FBH,6JLP,6JLU,6JLJ,6JLK,6JLL,6JLM,6JLN,6JLO,4X53,4TNJ,4TNK,4TNH,4TNI,5XNM,6AD4,6YVX,6YVZ,5GTH,4RFD,5NSM,5NSP,2I4C,2I4B,4EGS,4IT1,8F4E,4OYZ,2C1L,5H2F,1MZ4,3E2A,3KZI,5OX5,4IL6,7CZL,5XNL 769 57298696 28976 CHEMBL363707 DB01390 C00288 ZINC06827693 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49491 [O-]C([O-])=O InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2 BVKZGUZCCUSVTD-UHFFFAOYSA-L 26987 CHEMBL180485::CO3(2-)::SODIUM CARBONATE::carbonate::carbonate ion Carbonic anhydrase 4 Homo sapiens 5700000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26987&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CO3 1XVX,1GYT,3NXL,4C1K,2DXY,7RIE,7F6R,4W79,3MBU,4IXS,3CFL,3JZF,2PMS,2DWA,2DWJ,2DWI,2DWH,3UNI,3UNC,3UNA,7C19,7Q5I,2EHA,1B0L,2O7U,3VDF,2XMX,7XU8,6EEE,3IIZ,3IIX,1OVB,1OVT,1ALQ,4WWL,1CE2,1D4N,1BIY,8EZ4,3FGS,5LN5,2OWT,2H4I,1TFD,3U72,7EV0,4H0W,4G77,1B1X,7SRV,1TZ8,3VE1,1L1E,1OXL,1USH,1N84,3BDJ,2ZMB,1SUV,4GME,2ALU,2R9J,1KZI,4FOR,7QOS,3NCE,3C9Q,3ZLV,1NNT,3QYT,3CSI,1EH3,1VFD,4ZY1,4ZYQ,7D6O,3F9O,2HCA,2O1L,4K3N,5FPP,2QJE,5GKD,5NNM,1FCK,6U1K,8HXM,7LI0,7LI1,3O5F,3GLT,3NCB,1TPY,3HJO,3HJM,1SI0,1H76,3JRU,6CTC,5N6Y,3GQ7,1FQF,1FQE,3CRB,7K5K,7C0K,1B8L,3X2W,3X2V,1DSN,4ZX8,4ZX9,5JIW,5KOZ,2EWB,1B3E,5L6Q,1BLF,3E9X,6BQC,2NWJ,4JYE,4JYF,3AA0,6JBB,1CM5,1N5M,3LXV,3HK8,3HK9,3HK5,3HK7,3HKA,3HKR,4C5B,3T8W,1H43,1H45,1H44,4ZY0,4ZY2,1D3K,3IPN,1A8F,6NW9,4UEQ,4UE0,6W4Q,7FDW,1LCT,1LCF,4ELQ,4ELP,4ELR,2AYS,7BUG,4G2Z,2OEL,1DOT,4K1W,6EE2,3S9L,3S9N,6GUD,6GUR,4R76,4R7M,3M2Z,3TOD,1IBJ,3KQZ,8BIB,3O97,2NQX,1IOM,4DIG,7BFR,5E3K,4GRK,3RGY,3KJ7,4DXU,2XGF,6FEA,3TUS,3CI8,7W1D,2G93,3WT4,3TTR,5GH0,4FFL,3LOG,2NUV,1GV8,1GVC,1IEJ,4N6P,1SQY,2D5H,7RTM,3V7T,1N7W,1N7X,1N76,2VXH,2E9E,2P1S,3HEM,3PCD,2DP8,3UK4,7C6W,7C67,1OI8,1HSE,6CJ0,3VCN,3KMN,1LAM,1I6Q,1JNF,2GJM,3S9M,7C0S,5Z9O,4LF2,1GHI,1GHM,2YQU,3SDF,3TAJ,2R71,1KPH,1KPI,1KPG,2OJV,1J07,1J06,3SZJ,3V4S,2IPS,7YXC,1JQF,2DS9,2DSF,7C15,7C16,3MKV,1DTG,1HP1,4X2T,3UGW,1LFG,1LFI,3KQX,3D48,7EBY,4NED,5DYH,1QJM,3IB2,3IB0,3IB1,6OME,2E0S,3LQC,3KR4,3KR5,4P9G,3V5A,2DYX,7C0O,6J9Y,3HGI,1SDX,4IUW,7FHM,2EFB,1W80,4A0U,4FIM,3MJN,3MFL,4CUO,3S0M,1OD5,6RN5,2DVC,6WB6,2BJJ,1OQH,1OQG,2WA6,2WA7,2WA5,3GQ8,2A2S,2A2R,7EA4,2IKC,3IAZ,1VFE,2DOJ,2E1S,3U8Q,6IME,3K0V,2G8X,2DXR,6TN6,3USD,3NCC,6A1I,6A1E,6LAA,2WHP,2FA7,7ENU,1A8E,4G8H,2O51,4NJQ,4NJR,3MV4,1X8H,1X8G,1NKX,2O84,2O86,4IAK,4IAI,2DQV,3M5T,3M5S,4FJP,1N04,4A6V,5CBM,2B65,2D5F,7T3V,3GUI,3GUJ,3GUP,4B3E,3HA4,3K7J,5MMY,4GXR,4GXQ,1FWA,7ULD,6D02,6D03,6D04,6D05,2I48,5C2X,5DJL,2WU3,3ES6,6MBA,4R6T,4EJ5,2WHR,6FHC,2OCU,2PX1,7O1P,2Q8J,4Q9X,2GYV,2GYW 19660 57298697 28976 CHEMBL180485 DB06724 C00288 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49492 [O-][N+]([O-])=O InChI=1S/NO3/c2-1(3)4/q-1 NHNBFGGVMKEFGY-UHFFFAOYSA-N 26988 CHEMBL1644029::CHEMBL1644698::CHEMBL186200::NO3-::nitrate ion::nitrooxidane Carbonic anhydrase 4 Homo sapiens 58700000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26988&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search NO3 5ETB,6BJB,4LCH,4LCG,4LCF,4LC2,1GY3,3AJE,5O55,6K9Y,4BG4,7ZJJ,4GB7,5N35,6Q4T,3U5V,6I5D,2D4J,2D4I,5EV9,5EVA,3PEY,3PEW,3VRD,8C7Y,4JKN,6W0R,6SEW,6SET,6SEU,6SEZ,6SEX,2QTQ,4UI1,3JZ1,5KPF,6V71,2WV1,7VCJ,4O6R,7Q5F,5TRW,5ELM,5ELX,1DKK,1L0P,4QY9,5OB9,8DT7,1REM,1LJ3,1LJ4,1LJE,1LJG,1LJF,1LJI,1LJH,1LJK,1LJJ,2XM9,3DDE,4O02,1JKD,1JKA,1JKC,7MJB,6SSU,2J3R,6GOI,6GOJ,4HPK,3IID,6X6F,3N8F,5OWE,5IJI,2Q9U,2BOO,6K7C,2LZT,7BMF,2QCP,7XM7,5N91,4Z3M,5N9C,3TFK,5HPW,6ZS8,5FLH,6WP6,5VMN,2Q4D,4BFA,4NR5,4DMB,3W15,1VRP,4A9L,2W60,4ZEE,4E42,4BKM,1T3M,3WL2,2F4A,2F4G,4GVZ,3X0T,5UFH,3ED1,5OLE,4OPE,3UZD,5JGP,3MNV,2AZU,6XVT,7JMU,7PTB,7Z5O,1LKS,2XL6,6VUJ,4PFT,4PFY,5WHW,5AVJ,5BWJ,4KGH,6BSW,6BSV,4NU1,2ZMZ,2ZMY,2ZMX,6PZS,5O5H,6MOB,5OV8,5DRQ,5DRR,8AJ5,4GMR,5M43,6DMK,7AJP,6WQV,6A6M,3HIL,6U37,6U34,6LXU,3RBS,5O5A,5O5F,1SJN,2ZUV,3JUB,3JUC,3JUD,4WKZ,3PG9,4FFA,6LM1,4BJO,7CB2,2F30,3F2L,7JFN,7LU3,4GW2,4GW0,1E67,7XA9,5ETV,6CNZ,5OKC,5OKM,5ETD,4ZYE,7NN1,7NN4,4PHF,7MCJ,3MM8,2WPT,2WPQ,3Q1N,1ZCW,3F9U,6XYN,3C26,5URB,2ZWE,2ZWD,2ZWG,2ZWF,8BOY,6MAA,5HQ1,2AV6,3TMQ,2IA7,2ONS,2ONR,1NOL,3Q40,7ZAC,5YT7,1YDH,2YXW,2YXV,4CWB,3RL5,7TC5,7TC6,2C9P,2QAR,7QA4,6Z14,2XX3,2A74,5KC1,1NZR,3LWB,6TPN,6BGN,3BXI,3UYX,6ZLC,5O4S,6GI2,6GI0,6GI1,6GID,6RS7,5HMV,1E5Y,5AVK,3QXC,3QXJ,3QXS,5CS8,2W0J,6W3W,4E6F,2F2N,4GT4,3X2F,3EZH,7P52,6C5K,6Q6C,5G2V,6NMB,3AWY,3AWX,3AWS,3AWU,3AWT,3AWW,3AWV,3GZD,4ZXF,1JKB,3IB5,3G0V,3G0J,2WQ3,6UL7,6XXR,3C5Y,3FPC,7YYP,3KE2,7NJJ,5JT8,1M15,7NBY,5Y8Y,2ZQY,5MWG,5MWH,6S4I,3LMW,1IC6,3QBL,6JB8,6K2X,6K2W,6K2V,6K2T,6K2S,6K2R,6K2P,6LQ9,6LQN,6G5Y,6HRN,5NBF,5NB4,4QKQ,5EQW,5EQD,5EQ1,4UXW,4EY7,1ILS,2XSE,6GJ6,2XZK,4C2U,4WIN,7NNC,7A80,2CJ0,4V3H,4OH3,4EY6,4EY4,4EY5,5CRZ,5CRM,4ZFP,4E77,1T6A,1T6S,4IJZ,6FYM,5U53,4FQH,7P6M,2PI7,2HOR,3KKR,5KRE,7NL6,6FF5,4HON,4FZ4,7BU2,3MLE,2ZUW,2ZUT,2HPZ,3P52,5TI1,4CN5,7Z8A,2PQ2,5D0C,6ZPY,7F0V,5DZO,6IZJ,3MXZ,4R7S,2ATB,4A9S,7RXY,8FYQ,8FYP,8FYR,5EUW,4A9T,6TY7,1BG0,7A7P,7A7Y,6G6U,5NC0,5NC2,5NCP,5NCF,5NCG,6O5V,5KAS,5KAR,5Y8Z,5Y8W,5EPR,6OEL,4M0E,6TRL,5Y8C,3HDF,5VIX,7DQV,2YCR,2YCS,1CAN,4F1Q,4F1L,2FE4,4CVY,3JPZ,7RB6,5OWB,4QFU,2DQK,7TM5,5E3G,5E3D,4ELW,6VG5,4PPO,4Y55,3U40,6FXB,4BDH,4BDA,6CIY,6CIS,4KQC,5EFJ,5EFK,1A4C,8E54,3UAM,7NE1,7NEH,1SMC,3G28,3G21,3HRD,2WSU,2WSV,6SUS,1ZDW,6XZM,1ZV9,4XGX,4XGZ,3VIQ,1GIN,1GIM,7CIT,7CIY,7Z9A,3DY0,7TDS,7TDR,3CJM,3CJT,5GH0,7RYD,7RYK,5ZML,2ID8,3AWZ,3B6R,6TXG,2ZAE,4M4U,4M4V,5FF1,6J6V,6J6W,4QI8,3AON,4N6Q,1LZN,4DC9,7ACK,5HFR,6D6F,7LTI,7LTD,7LTV,2E9E,2E9S,3LZT,6NX0,3BWZ,8ING,6JU7,6JU6,6JU9,6JU8,3K3B,4PZG,6U7V,4F07,7PNH,5BKQ,7RCQ,3EBL,5LVK,5E29,5CP5,7ZKX,4BV3,7TM4,6WP3,3CW9,6CJ1,5KZA,2VB1,6DWQ,4K8M,7PR0,3KM5,2CWA,4ENF,5IDD,6VSO,5ZCY,4ZUP,4ZUM,7OW9,6X3B,3ETC,3LEH,3NO0,5C85,5C7N,3RU5,5I5Q,4Z46,4Z41,5AL7,4Z4V,4Z4T,7B1Z,5NJ1,6O2H,3BAY,3BAI,3BAJ,3BAK,6PQ4,7QPE,7BBU,7KH8,7BI7,1AZR,5ER9,7LU2,7LU0,7LU1,4RF8,6TLE,4EQK,1CH8,1SEG,2FCK,7S4Z,1P50,1P52,2XPX,7F19,4AZU,7LXI,2V6O,6POL,4PV2,1OHZ,1T5C,3F7J,2DUJ,4A94,5K3Q,4A9U,4A9R,1WX2,1WX4,1WXC,4BWW,4ZTX,4ZTY,2P4G,8A27,5UYT,7T7A,4K4R,4K4Q,4K4P,1IZN,3QDP,3AX0,1LMA,4NET,2XVE,2XVF,5T4U,2XVI,2XVJ,5DY7,5DYA,5DYC,5WRC,7W9Z,6RD2,7C2B,7AP5,7W0S,2PP9,6TZN,7JTA,1CIB,6GCV,4RSZ,4Z4S,1V7T,1V7S,1YTN,4BOS,1SD0,1ZB6,4IU8,4IUK,4F2I,2FBB,7BE0,7BE1,7BEB,7BEC,2G29,5A3Z,5HFA,5HF9,5HF8,5HF5,6D6H,6D6E,6D6G,5G3S,5E43,2CN5,2CN8,4V7N,4D7Q,5CVJ,5CVU,5TC9,7NUZ,5C87,6EKQ,1P9B,6CD5,5Z0I,5Z0H,5Z0K,5Z0J,5Z0M,5Z0L,5Z0E,5Z0D,5Z0G,5Z0F,5KXU,5KXV,6M60,3DA4,4ZWN,4HS1,6EFU,5BSY,4MJZ,4J5M,5JBV,7SKW,7CJG,3KXQ,4CRJ,5FG5,2AH6,2AHK,2AHL,3COG,3M6F,6RCJ,6RCF,5NDU,5ND0,4AE2,6O4X,6O4W,2YBI,4BE9,3RF0,2Q3V,1SNF,6ZUP,4GDI,4YEO,6I70,3DCJ,6QL8,3IVA,7L9U,4WOE,3IAR,6TNM,4LZT,4ON3,2YIQ,2YIR,2YIT,5CXL,4B0Z,5YSU,7BEI,1JSF,7FEH,6F92,3NQ8,6GOB,6FWU,7B7S,5A2O,6CR1,1VM0,4XQ1,7Z1E,4U4T,4U4W,4A1Z,6QEA,5UVL,1HF4,2WT1,2WT0,2WT2,2WTC,2WTD,2WTI,2WTJ,6UKD,6XU3,3FOV,5TT1,6EHH,2EJW,5Z1T,5Z1R,5Z1S,5UNL,1P7V,1P7W,7Y6A,5J99,5J9A,6ZVG,4NJ4,2XCB,5W16,5JON,3MVC,6SQO,6SQR,6SQP,4FAS,2OBP,2H9C,2PYZ,2O86,7YXV,6MH6,5JZK,4IA6,2O08,5NEG,2W7X,7AVF,7AVG,7AVE,3O1Y,3OSZ,3OSJ,4F4H,6O50,6O5Y,6O5E,4LD1,4M0F,5LYM,1GZQ,2YCF,2YCQ,1II6,4BDJ,4BDK,4BDI,4BDF,4BDG,4BDD,4BDE,4BDB,4BDC,2YBH,3GA1,5FAG,4DOI,1SM8,6WVO,5EWC,5EWV 943 57298698 29785 CHEMBL1644698CHEMBL1644029 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49493 [O-]N=O InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1 IOVCWXUNBOPUCH-UHFFFAOYSA-M 26989 CHEMBL93268::NO2-::nitrite::nitrite ion Carbonic anhydrase 4 Homo sapiens 30800000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26989&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search NO2 1WA2,2XWZ,1J9T,2DWT,2DWS,2XX1,5VZO,5VZN,5VZQ,5VZP,5OG5,5D4I,5D4H,1FDI,5AKR,5NGX,3V2Z,3V2V,7ZCR,7ZCS,7ZCP,7ZCQ,7ZCN,7ZCO,3VKP,3TGC,1SJM,5HLX,3X1N,5F7A,3MM9,2FRF,2FRI,3BNH,6QQ2,3S7W,3RKH,3OO5,3OO4,1AS8,1AS6,4CSZ,5TR7,3D1I,6GT0,6GTL,6GTN,6GTI,6GTK,6FL2,3OUO,5OBO,5HWZ,3ONZ,4JRE,2XZI,2QMK,3VKR,3VKQ,7OU5,7OU7,7OU9,7OUY,5Z7E,5Z7F,5UT9,5UT7,3MLK,5UTA,5UTD,3GEO,5NC0,2E80,4N8T,6QWG,3OWM,4M4U,4L3Y,4L3X,4L3Z,4L38,8ING,3HEO,3HEP,6NU9,6TFD,3WKP,5OGG,5OGF,5OG3,5OG4,5OG6,5ZCY,6PDV,3OV9,3Q09,6GB8,6GBY,5OG2,5OFF,5OFG,5OFC,5OFH,5OF6,5OF7,5OF5,5OF8,4G1V,1NID,1NDS,2PPC,4I6Y,3VAU,3Q08,1J9R,1J9S,1J9Q,3LR7,3LR9,2YBI,2YBJ,2YBN,2BWD,2BWI,6ZAX,6ZAU,6ZAT,6GBB,2QV4,7WYJ,3MIB,3MIG,2O5S,2O5O,3MVF,3VM0,1L9O,1L9P,1L9Q,1L9R,1L9S,1L9T,3D7O,5I6P,5I6K,5I6L,5I6M,5I6N,2YBL,1KBV,6QPX,6QPT,2JIR,2JIQ,6CF0,6ZU6,6ZUB,6ZUA,6ZUD,5AG1,6QQ0 946 57298699 16301 CHEMBL93268 DB09112 C00088 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49494 [SH-] InChI=1S/H2S/h1H2/p-1 RWSOTUBLDIXVET-UHFFFAOYSA-M 26990 CHEMBL1644699::HS anion::HS(-1)::hydrogen(sulfide)(-1)::hydrosulfide::sulfanide Carbonic anhydrase 4 Homo sapiens 3900000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26990&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search S 5047209 57298700 16136 CHEMBL38703CHEMBL1644699 C00283 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49495 OS([O-])=O InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 LSNNMFCWUKXFEE-UHFFFAOYSA-M 26991 CHEMBL1689285::HSO3-::bisulfite::hydrogen sulfite Carbonic anhydrase 4 Homo sapiens 13200000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26991&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1DD7,1EAF,1FT6,1I9D,1J3M,1JNZ,1JZW,1K0I,1K0L,1LTD,1NRS,1OKG,1R8S,1TLL,1URH,1VYB,1WMG,1YT8,2C3J,2CBD,2D2X,2E1D,2GAG,2GEP,2GRU,2HCI,2HZ1,2ORO,2PCJ,2V3P,2V4J,2VQ2,2VVH,2VVI,2VVJ,3BNF,3BNJ,3C7B,3F29,5CAC 104748 57298701 17137 CHEMBL1689285 C01615 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49496 [O-]S([O-])(=O)=O InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 QAOWNCQODCNURD-UHFFFAOYSA-L 26992 CHEMBL183495::SO4(2-)::SODIUM SULFATE::sulfate::sulfate ion Carbonic anhydrase 4 Homo sapiens 9000000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26992&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SO4 5R46,1VYB,1VYW,3B3R,1Y6V,7RPG,5R4Y,1Y62,5ETC,1W2T,1P09,5R4E,5R4D,5R4F,5R4A,1P06,5R4B,1XVI,1XVO,1K6U,1K6S,7LNR,7LNQ,7LNO,7LNE,7LN7,1NGP,1NGQ,1NGK,3LTO,3LTQ,6O6Q,2NPK,2NPE,2NPG,6TW6,3O8Z,6O63,6BJ3,3O89,2NP8,1W9Y,4LCT,4LCV,4LCC,4LC6,4LC0,6Y6Q,2ZDC,2ZDL,2ZDI,2ZDK,6Y6N,9LDT,1W9D,2ZD1,4M1G,4M1E,4M1L,1VBG,6PUB,6PUX,4L0J,4L0V,1VBP,5Y2F,5Y2G,5Y2P,1YLP,1YLQ,1YLW,1YLT,1YLC,1YLD,1YLJ,1GYR,4JV9,2X4X,2X4Y,2X4M,2X4F,4JVZ,2X47,4JVH,4JVJ,6J1T,6J1S,6J1R,6J1Q,6J1P,3GCB,3GCA,3GCZ,3GCT,5FCZ,5FCU,5FCR,5FCS,5FCM,3GC6,3QV7,3QV2,3QV1,1IHP,1IHX,1IHY,3QVM,3QVE,3QVX,7CYU,3KWR,3KWZ,3LBB,1E3P,4QNX,4QNL,4QNH,3N6Y,3N6X,4QN9,3N6Z,3N6U,3N6T,3N6W,3N6O,3N6H,3LB3,5CA7,5CAZ,5CAX,5CAS,5CAQ,5CAP,5CAW,5CAU,5CAN,5CAB,5CAG,3AJF,3AJX,1G3L,1G3C,1G3B,1G3E,1G3D,1G3P,1G3U,1G3W,1G33,1G36,3U1U,7LEH,7LEG,7SGQ,6JKE,3HOS,3HOT,3HOI,3HOM,6JK5,6JK2,5VLQ,5VLX,6K9C,2BU9,6K9U,2Q7D,2Q7J,2Q7K,2Q7I,2Q7W,2BUC,2BUA,2Q79,2PZP,2PZR,3E2W,7A61,4LKT,3NX0,3NXR,3NXV,3NXT,3NXY,3NXF,3NXE,3NXK,3NXJ,3NXO,3NXN,6ZOC,7A6I,6ZOD,6ZOG,6ZOF,6ZO5,4BGP,1NNR,1CFB,1CFW,3RD0,3RDO,1CF2,3RDP,3RDW,2LDB,5O70,5O75,4NS2,4NS1,4NS0,5O7Q,4C1C,4C1F,4C1G,4C1H,4C1M,4C1O,4NSV,1TZM,7T3E,1F75,1F77,1TZB,1F7Z,1F7U,6F6R,6F6Q,8DTW,8DTC,6F60,7R9F,8AGR,4HC3,1EUA,1EUC,1EUD,1EUH,1EUN,1EUZ,8AG9,1EU1,4DN9,3WXF,1SLF,3WX2,3WX1,4DNZ,4DNE,1Z42,4IMV,4IMK,2QYJ,2QYT,2QYV,4IM7,1XOS,1H85,1H8Z,1H8Y,1H8U,1H8S,1H8O,1H8N,1H8L,1H8E,8J0V,8J0U,8J0Z,8J0X,8J0Y,8BGC,7ZJB,6IKZ,6Z9V,6IKX,6Z9X,6IKJ,6IKK,6IKI,6IKM,4AUV,1PPM,1PPL,1PPK,1PPH,1PPZ,1PPY,4GBS,4GBM,1PP8,2AEE,2AEC,2AEU,2AEV,2AEP,2AES,2DXY,4YGT,4YGW,2AE4,2AE5,2AE7,5XFY,1FM7,1FM8,6NRH,1FMZ,1FMG,1FMI,6DTW,6Q4O,6Q4P,6Q4T,3VWI,3W60,3W61,3W62,3W63,3W64,3W65,3W69,4LL7,2FJG,3BO9,2O2G,4TM8,1HBZ,7BM7,7BM1,7BM2,1HB8,1HB4,1HB1,1HB0,1HB3,1HB2,7ZSM,2O2Q,2O2P,7ZSC,2RNS,7ZSZ,1DNU,1DNW,2DSI,3E5O,3VB0,2VCS,1O6I,1O6T,6I5N,6I5F,3O8B,3O8C,6TW5,3BDP,2ZM2,3O8R,3O8Q,6O65,7RIA,7RIB,7RIE,7RI1,5NYX,5NYR,5NYW,5NYN,5NYO,5NYM,5IEI,6RVG,6RVE,6RVC,6RVM,4W99,3E9Z,3BD1,6IPK,6IPJ,4B9A,6CY1,2HQ5,7F68,7F65,7F6R,7F6U,7F6K,7F6M,7F6O,5HNG,5HNM,5HNR,5HN1,4XHL,5HN8,3V83,8FH2,8FH0,8FH1,6QJL,6QJI,6QJK,6QJJ,6QJE,6QJD,3V8W,3V8T,3V8D,5KK4,5KK7,5KKC,5KKE,5KKD,5KKK,5KKW,1KAE,2D48,2IT1,2D4R,2ITM,8AO9,6Y6L,6Y6O,1GKJ,7MO0,9LDB,4WMA,4WMB,4WMI,4WMK,1YE6,7R3S,7R3P,7R3Q,7R3Z,4WM9,1W03,1W04,1W05,1W06,5EV5,5EVI,1W0Z,5EVB,5EVC,1W0D,1W0I,1W0N,3PE4,3PE2,3PE1,3OG3,3PEV,3PEU,3OGF,3PEJ,3PEH,3PEI,3PEG,3PED,3OGT,1VDC,4ARJ,4ARH,4ART,1YEX,1YEA,4LZ0,1YEB,5LTV,7U5B,6TAO,3VRI,3VRG,2VSQ,7ERD,3C8B,6DD4,6DD5,7A44,7A45,7A40,6DDI,6DDW,6DDR,7A4T,1GRQ,3V1R,1XM2,3C8M,7LQX,7LQP,7LQU,6E03,6E02,6E00,6E04,6E0W,1NRK,1NRZ,1NR6,1NR4,4W70,4W79,6NS7,4W7D,4W7Z,6NSD,6NSL,6NST,6TH4,6THN,6THF,6THD,4A8H,4LXU,4A8E,4A8G,4A8Z,4A8U,4A8V,4LX1,4A88,4A81,4A80,4A83,4A85,4A84,4A87,4A86,2CFL,2CFK,2CFI,2CFG,2CFD,2CFW,3BPM,3BPK,1WZF,3BP3,1YYD,3TOZ,1E34,4JKX,4JKN,4JKJ,4JKI,4JK6,4JK5,4JK0,6AEZ,3UQP,3UQV,3UQU,3UQI,2X9I,1WZ9,4OL8,7WN7,7WN2,2ILM,4JV7,4OLH,4OLF,4OLE,7COZ,2YOB,2YOC,2YOR,3GT4,3GT2,3GT3,6WZ0,7CRA,6WZQ,6WZV,4JVP,8H9D,2JFT,7EKK,7N3V,8DV0,7N3K,7N39,6T6H,6T6A,6T6D,1WAU,6YWU,6YWR,6YW4,6YW3,2JFA,2JFF,3C89,4B2Z,4B2M,4B2H,4B2J,4B2K,1WA3,1WA2,1WA0,1WA6,1G8F,1G8T,1G82,2XWZ,2XWD,7CFB,2W53,2W5O,2W5P,4ZJM,4ZJX,4ZJY,6W0N,6JPL,6W0Z,6JPJ,6JPE,6W0U,3HBT,3HBB,3HBM,3HBK,6JP6,6W04,3HB6,5VWK,5VWT,5VWU,3K6O,3K6H,3K6K,3K6W,3K6X,3FLK,3K60,6MPX,2V6X,8I1Z,8I1Y,3NW2,6LCT,6LCB,6LCA,3NWR,3NWU,3NWZ,3NWX,3NWB,3NWE,6LC9,6LC8,6LC7,6LC5,6WOG,6WOA,3MBZ,3MBQ,3MBJ,3MBK,1UJM,6WOH,4BHR,3MB6,3MB7,3MB5,3MB2,4BHM,5FC7,5FC1,1T2U,1T2H,6WO8,6WO9,7FKR,5FCK,8DAM,3CQI,3CQH,3CQK,3CQL,3CQA,6MYW,3CQ9,3CQ5,6MYK,1ENF,1ENT,5MLW,6SE2,6SE1,6SEN,2F5C,2F5Z,1SAR,3AUG,3AUE,2F55,3AUH,8AJY,4IXX,4IXM,4IXL,4IXN,2QTF,2QTR,7QVB,4IX0,1YA8,6URM,6URQ,6UR7,6UR9,1YA0,6AL3,5T5T,1Q93,1Q97,1Q96,4F78,2YIH,2YIL,2YIO,3CFL,7AAD,1PGN,1PGO,1PGJ,1PGP,1PGQ,4GYY,4GYW,4GYP,4GYH,1PG8,5LHV,7CP0,7PTJ,1FX2,1FX7,1FX9,7WGU,1FXR,1FXJ,1FXO,6FUO,6FUM,6FUL,6FUK,4UI3,4UI6,6FUR,6FUQ,4UI7,4UI4,4UI5,4UI8,5JNB,1E4D,1E4E,1E4B,1E4C,5ZRU,1E4A,1E4M,7CPN,5ZR2,5ZR8,1E46,1E47,1E49,2P2G,2J0L,4TRR,4TRQ,4TRU,4TRF,3N90,3N94,3FFT,3FFW,3FFY,3FFX,3FFA,3FFB,3FFO,3FFH,1HY0,4UIM,5U1H,5U1O,7EF8,1HYZ,1HYU 1117 57298702 29922 CHEMBL183495 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49497 F[B-](F)(F)F InChI=1S/BF4/c2-1(3,4)5/q-1 ODGCEQLVLXJUCC-UHFFFAOYSA-N 26993 BF4(-)::CHEMBL1780189::Tetrafluoroborate::tetrafluoroboranuide Carbonic anhydrase 4 Homo sapiens >200000000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26993&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 26255 57298703 38899 CHEMBL1780189 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49498 NS(O)(=O)=O InChI=1S/H3NO3S/c1-5(2,3)4/h(H3,1,2,3,4) IIACRCGMVDHOTQ-UHFFFAOYSA-N 26994 CHEMBL68253::H2NSO3H::sulfamic acid Carbonic anhydrase 4 Homo sapiens 930 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26994&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5987 57298704 48266 CHEMBL68253 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49499 NS(N)(=O)=O InChI=1S/H4N2O2S/c1-5(2,3)4/h(H4,1,2,3,4) NVBFHJWHLNUMCV-UHFFFAOYSA-N 26995 CHEMBL355001::H2NSO2NH2::sulfamamide::sulfamide::sulfamoylamine Carbonic anhydrase 4 Homo sapiens 880 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26995&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search FUS 6D2N 82267 57298705 48266 CHEMBL355001 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49500 OB(O)c1ccccc1 InChI=1S/C6H7BO2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9H HXITXNWTGFUOAU-UHFFFAOYSA-N 26996 CHEMBL21485::PhB(OH)2::Phenyl-boronic acid::Phenylboronic acid, 22::benzeneboronic acid::phenylboranediol::phenylboronic acid Carbonic anhydrase 4 Homo sapiens 880 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26996&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PBC 6VIM,1JU3,6UQU,4OB0,2A32 66827 57298706 44923 CHEMBL21485 DB01795 C16200 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49501 O[As](O)(=O)c1ccccc1 InChI=1S/C6H7AsO3/c8-7(9,10)6-4-2-1-3-5-6/h1-5H,(H2,8,9,10) LVKZSFMYNWRPJX-UHFFFAOYSA-N 26997 CHEMBL364571::PhAsO3H2::benzenarsonic acid::benzenearsonic acid::phenylarsonic acid Carbonic anhydrase 4 Homo sapiens 870 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.12.082 10.7270/Q2KD1W79 19128966 aid1798763 Innocenti, A; Hilvo, M; Parkkila, S; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26997&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7365 57298707 29851 CHEMBL364571 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 49525 NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16) LMJSLTNSBFUCMU-UHFFFAOYSA-N 26998 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide::TRICHLORMETHIAZIDE::trichloromethiazide, 6 Carbonic anhydrase 4 Homo sapiens 449 7.5 20.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2008.12.023 10.7270/Q2FN14HZ 19119014 aid1798767 Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26998&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search B7D 1ZGF 5560 57298708 DB01021 7314 C07767 ZINC00897236 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 47578 Oc1ccccc1 InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H ISWSIDIOOBJBQZ-UHFFFAOYSA-N 26187 α-CA inhibitor, 11::CHEMBL14060::US9688816, 2::phenol Carbonic anhydrase 4 Homo sapiens 9500 Curated from the literature by BindingDB 10.1016/j.bmc.2008.06.013 10.7270/Q2X065C8 18579385 aid1798641 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26187&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IPH 2PZV,3NX8,1XDA,4OLA,1MPJ,1PN0,5HPU,7AT0,1XW7,3AIY,3NC0,5USS,1JHY,1JHX,1WAV,2OMB,2OMN,3ROV,1FOH,5KI6,4W5Q,4W5R,4W5T,4W5N,1Q4V,4W5O,5URU,5JS1,5JS2,3ZS2,1XU5,6IY8,1AIY,5UU4,5UU3,6MFN,6MFR,1LI2,3Q3O,7JP3,3V1G,3V19,3JSD,5AIY,6Q7S,4A71,5FRW,2OLD,3ZQR,6TYH,3KQ6,3P2X,4JMW,5KBE,2WS6,2WS7,2J9N,1ZNJ,6MDZ,5ILG,1V03,7WDG,7WDH,1RWE,3KMH,4Z4F,4Z4G,4Z4D,4Z4E,4Z4C,4Z4H,4Z4I,1QIY,5BQQ,4F3T,1ZEG,6CK2,5W3R,4AIY,7VQF,1FJW,3GKY,4P65,5NQ8,1W8P,3U3E,5EMS,4AJZ,5T7B,3F39,4H07,4I7L,1AI0,1AI7,4AKJ,2AIY,2VE7,5HRQ,3GUO,5UDP,5WEA,4HDS,5UQA,2AS3,3P33,1LPH,6Z44 996 56464624 15882 CHEMBL14060 DB03255 C00146 ZINC05133329 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 47579 Oc1ccccc1O InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H YCIMNLLNPGFGHC-UHFFFAOYSA-N 26188 α-CA inhibitor, 12::1,2-Dihydroxybenzene, XI::1,2-dihydroxybenzene::CHEMBL280998::benzene-1,2-diol::phenol derivative, 2 Carbonic anhydrase 4 Homo sapiens 10900 Curated from the literature by BindingDB 10.1016/j.bmc.2008.06.013 10.7270/Q2X065C8 18579385 aid1798641 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26188&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CAQ 2BUY,2BUQ,4QON,3HHY,2PUM,4ZXT,5KBI,3O4M,6S2H,1DLT,5SWG,7WKM,7WKL,1XEP,3FW4,4K7I,7KK0,7WJR,3T67,7WMB,1KND,7BP1,5VXT,3MI5,5G4H,4OOW 289 56464625 18135 CHEMBL280998 DB02232 C00090 ZINC13512214 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 47580 Oc1cccc(O)c1 InChI=1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H GHMLBKRAJCXXBS-UHFFFAOYSA-N 26189 α-CA inhibitor, 13::1,3-Dihydroxybenzene, XII::1,3-dihydroxybenzene::CHEMBL24147::US9688816, 4::benzene-1,3-diol::phenol derivative, 3 Carbonic anhydrase 4 Homo sapiens 570000 Curated from the literature by BindingDB 10.1016/j.bmc.2008.06.013 10.7270/Q2X065C8 18579385 aid1798641 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26189&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search RCO 2OLY,2OLZ,3ZU1,4QOO,4DM3,4E49,2OMH,2OMI,2OM0,2OM1,6GSG,3AQT,1EVR,1QIZ,4AJX,4Z10,2W44 5054 56464626 27810 CHEMBL24147 C01751 ZINC00002028 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 47581 Oc1ccc(O)cc1 InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H QIGBRXMKCJKVMJ-UHFFFAOYSA-N 26190 1,4-Dihydroxybenzene, XIII::1,4-dihydroxybenzene::CHEMBL537::Hydroquinone (9)::Hydroquinone, HQ::benzene-1,4-diol::phenol derivative, 4 Carbonic anhydrase 4 Homo sapiens 10800 Curated from the literature by BindingDB 10.1016/j.bmc.2008.06.013 10.7270/Q2X065C8 18579385 aid1798641 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26190&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search HQE 4QOP,3ZOF,3ZOD,5I3B,7NNX,7NMP,7NIY,5FSE,4E3H,5I3A 785 56464627 17594 CHEMBL537 C00530 ZINC05133378 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 47582 Oc1cc(F)ccc1F InChI=1S/C6H4F2O/c7-4-1-2-5(8)6(9)3-4/h1-3,9H INXKVYFOWNAVMU-UHFFFAOYSA-N 26191 2,5-difluorophenol::phenol derivative, 5 Carbonic anhydrase 4 Homo sapiens 426000 Curated from the literature by BindingDB 10.1016/j.bmc.2008.06.013 10.7270/Q2X065C8 18579385 aid1798641 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26191&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 94952 56464628 52879 ZINC00409280 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 47583 Oc1cc(F)cc(F)c1 InChI=1S/C6H4F2O/c7-4-1-5(8)3-6(9)2-4/h1-3,9H HJSSBIMVTMYKPD-UHFFFAOYSA-N 26192 3,5-difluorophenol::phenol derivative, 6 Carbonic anhydrase 4 Homo sapiens 10700 Curated from the literature by BindingDB 10.1016/j.bmc.2008.06.013 10.7270/Q2X065C8 18579385 aid1798641 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26192&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 75928 56464629 52879 ZINC00406989 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 47584 OC(=O)c1ccccc1O InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10) YGSDEFSMJLZEOE-UHFFFAOYSA-N 26193 2-Hydroxybenzoate, I::2-hydroxybenzoic acid::CHEMBL424::phenol derivative, 7::salicylic acid Carbonic anhydrase 4 Homo sapiens 11100 Curated from the literature by BindingDB 10.1016/j.bmc.2008.06.013 10.7270/Q2X065C8 18579385 aid1798641 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26193&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SAL 3BPX,3UNI,3UNC,3UNA,3N8Y,6WPG,3REM,3RET,5EVY,7LH2,6L4M,5X80,3DEU,1FO4,7S9E,7S9A,7V75,4HVR,2I30,5M78,5SWR,3ZMD,3NJZ,6EMM,2Y7K,2I2Z,5F1A,7EN1,3B9M,6UX1,4EM2,4EM0,3KP6,5S96,4L39,6TM4,1WYG,3W1W,1PTH,1FIQ,2FN1,4EQ4,4EQL,5U6M,5U6N,5OF1,7EMY,5WM2,3TWP,5YJS,3AX7,3AX9,1JGS,3GF2,2Y7P,2Y7W,7BNI,3HGX,1M6E,2E1Q,6ZA5,7KJL,1Y7I,6JQX,3NVC,4Y03,6YMO,6S37 338 56464630 16914 CHEMBL424 DB00936 4306 C00805 ZINC00001554 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 47585 OC(=O)c1ccc(O)cc1 InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10) FJKROLUGYXJWQN-UHFFFAOYSA-N 26194 4-Hydroxybenzoate, III::4-hydroxybenzoic acid::CHEMBL441343::p-Hydroxybenzoic acid::phenol derivative, 8 Carbonic anhydrase 4 Homo sapiens 809000 Curated from the literature by BindingDB 10.1016/j.bmc.2008.06.013 10.7270/Q2X065C8 18579385 aid1798641 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26194&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PHB 2BUW,2BUR,1G81,1BKW,6KCL,6KCM,6KCK,1IUW,1IUV,1IUX,1PXB,1PDH,3ZYB,1G1B,1CJ2,1Q4S,5D2A,4LKE,4LKD,4LKF,4OD5,1CC4,1PBE,1BF3,4EVS,4EVQ,4EY3,3TYB,1BGJ,1BGN,1DOB,1DOC,5IGA,2PHH,1PXA,7CUO,1K0I,4F06,3PCC,5I5P,1CJ3,7DQB,1TT8,6AL9,1JD3,1PXC,1CC6,1YKJ,3HGR,3HGS,1D7L,5RTJ,4E3G,1CJ4,3R3A,3R36,1FW9,7ON9,5W1E,5M21 135 56464631 30763 CHEMBL441343 DB04242 C00156 ZINC00332752 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 47586 Nc1ccc(O)cc1 InChI=1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2 PLIKAWJENQZMHA-UHFFFAOYSA-N 26195 4-aminophenol::phenol derivative, 9 Carbonic anhydrase 4 Homo sapiens 743000 Curated from the literature by BindingDB 10.1016/j.bmc.2008.06.013 10.7270/Q2X065C8 18579385 aid1798641 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26195&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4NL 2ORL 403 56464632 17602 C02372 ZINC04623758 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 47587 Oc1ccc(cc1)C#N InChI=1S/C7H5NO/c8-5-6-1-3-7(9)4-2-6/h1-4,9H CVNOWLNNPYYEOH-UHFFFAOYSA-N 26196 4-cyanophenol::4-hydroxybenzonitrile::phenol derivative, 10 Carbonic anhydrase 4 Homo sapiens 634000 Curated from the literature by BindingDB 10.1016/j.bmc.2008.06.013 10.7270/Q2X065C8 18579385 aid1798641 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26196&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search H8N 4ZXA 13019 56464633 38622 ZINC00388759 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 47588 CC(=O)Nc1ccc(O)cc1 InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10) RZVAJINKPMORJF-UHFFFAOYSA-N 26197 CHEMBL112::N-(4-hydroxyphenyl)acetamide::Norco::Paracetamol::US9333197, Acetaminophen::acetaminophen::phenol derivative, 11 Carbonic anhydrase 4 Homo sapiens 11400 Curated from the literature by BindingDB 10.1016/j.bmc.2008.06.013 10.7270/Q2X065C8 18579385 aid1798641 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26197&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search NNS 1TYL,1TYM,2DPZ,2OCU,3DJI 1983 56464634 46195 CHEMBL112 DB00316 5239 C06804 ZINC18274777 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46778 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 7.4 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.105 10.7270/Q27D2SF1 18640037 aid1798596 Temperini, C; Innocenti, A; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46779 CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 KJADKKWYZYXHBB-XBWDGYHZSA-N 10887 Sulfamate 7::Topiramate (TPM)::US11535599, Example topiramate::[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate Carbonic anhydrase 4 Homo sapiens 4900 7.4 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.105 10.7270/Q27D2SF1 18640037 aid1798596 Temperini, C; Innocenti, A; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10887&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TOR 3LXE,3HKU,5JNA 5284627 46511457 63631 DB00273 6849 C07502 ZINC01530804 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46780 NS(=O)(=O)Oc1ccc2c3CCCCCc3c(=O)oc2c1 InChI=1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18) DSLPMJSGSBLWRE-UHFFFAOYSA-N 13058 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate::667-COUMATE::667COUMATE::BN83495::CHEMBL286738::CMT::STX64::{9-oxo-8-oxatricyclo[8.5.0.0^{2,7}]pentadeca-1(10),2(7),3,5-tetraen-5-yl} sulfamate Carbonic anhydrase 4 Homo sapiens 24 7.4 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.105 10.7270/Q27D2SF1 18640037 aid1798596 Temperini, C; Innocenti, A; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13058&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 667 1TTM 5287541 46513478 CHEMBL286738 DB02292 ZINC01549366 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46781 NS(=O)(=O)Oc1ccc2C=C(CC3CCCCCC3)S(=O)(=O)c2c1 InChI=1S/C16H21NO5S2/c17-24(20,21)22-14-8-7-13-10-15(23(18,19)16(13)11-14)9-12-5-3-1-2-4-6-12/h7-8,10-12H,1-6,9H2,(H2,17,20,21) BIASYWBGUYOWJR-UHFFFAOYSA-N 25896 EMD 486019::[2-(cycloheptylmethyl)-1,1-dioxo--benzothiophen-6-yl] sulfamate Carbonic anhydrase 4 Homo sapiens 842 7.4 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.06.105 10.7270/Q27D2SF1 18640037 aid1798596 Temperini, C; Innocenti, A; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25896&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2C7 3DD8 11245700 56413184 DB06954 ZINC39123364 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46842 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13) JZUFKLXOESDKRF-UHFFFAOYSA-N 13076 6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide::BMCL182567 Compound 6a::Dichlothiazide::Hydro-D::Hydrochlorothiazide::Hypothiazide::JFD00715::Oretic::cid_3639 Carbonic anhydrase 4 Homo sapiens 427 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.03.051 10.7270/Q23N21P7 18374572 aid1798598 Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13076&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search HCZ 3IK6,3IJX 3639 46513493 DB00999 4836 C07041 ZINC00896569 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46843 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1C(F)(F)F InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16) DMDGGSIALPNSEE-UHFFFAOYSA-N 25897 1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide::BMCL182567 Compound 6b::Diuredemina::Glomerulin::Hydroflumethiazide::cid_3647 Carbonic anhydrase 4 Homo sapiens 4780 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.03.051 10.7270/Q23N21P7 18374572 aid1798598 Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25897&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search HFZ 3ILU 3647 56413185 DB00774 7197 C07763 ZINC00897225 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46844 CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23) AQCHWTWZEMGIFD-UHFFFAOYSA-N 25899 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide::Diulo::Metolazone::Microx::Zaroxolyn Carbonic anhydrase 4 Homo sapiens 216 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.03.051 10.7270/Q23N21P7 18374572 aid1798598 Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25899&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4170 56413187 64354 DB00524 4838 ZINC00896755 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46845 NS(=O)(=O)c1cc(ccc1Cl)C1(O)NC(=O)c2ccccc12 InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21) JIVPVXMEBJLZRO-UHFFFAOYSA-N 25900 2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide::Chlortalidone::Chlorthalidone::Chlorthalidone (1)::Hygroton::Phthalamudine::US10172837, Chlorthalidone Carbonic anhydrase 4 Homo sapiens 196 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.03.051 10.7270/Q23N21P7 18374572 aid1798598 Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25900&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search KLT 3F4X 2732 56413188 3654 DB00310 7147 ZINC00057255 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46846 CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23) NDDAHWYSQHTHNT-UHFFFAOYSA-N 25901 4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide::Indaflex::Indapamide::Indapamide (2)::Lozol::Noranat Carbonic anhydrase 4 Homo sapiens 213 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.03.051 10.7270/Q23N21P7 18374572 aid1798598 Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25901&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BL1 3BL1 3702 56413189 5893 DB00808 7203 ZINC00643114 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46847 NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) ZZUFCTLCJUWOSV-UHFFFAOYSA-N 25902 4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid::CHEMBL35::Frusemide::Furanthril::Furosemide::Furosemide (3)::Furosemide, 4::Lasix::US10172837, Furosemide Carbonic anhydrase 4 Homo sapiens 564 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.03.051 10.7270/Q23N21P7 18374572 aid1798598 Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25902&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search FUN 7N3N,1Z9Y,6SG0,2XN5,8STE,7SFL,3RF4,6DE9 3440 56413190 47426 CHEMBL35 DB00695 4839 C07017 ZINC00035804 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46848 CCCCNc1cc(cc(c1Oc1ccccc1)S(N)(=O)=O)C(O)=O InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23) MAEIEVLCKWDQJH-UHFFFAOYSA-N 25903 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid::Bumetanide::Bumex::Burinex::Fordiuran::cid_2471 Carbonic anhydrase 4 Homo sapiens 303 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.03.051 10.7270/Q23N21P7 18374572 aid1798598 Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25903&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 82U 7SMP,7S1Y,7S1X 2471 56413191 3213 DB00887 4837 ZINC03813061 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46959 NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1)S(N)(=O)=O InChI=1S/C15H14N4O3S/c16-19-15(20)14-13(9-4-2-1-3-5-9)11-8-10(23(17,21)22)6-7-12(11)18-14/h1-8,18H,16H2,(H,19,20)(H2,17,21,22) PPDLAUCFAOODER-UHFFFAOYSA-N 25904 2-(hydrazinecarbonyl)-3-phenyl-1H-indole-5-sulfonamide::BMC173212 Compound 1::CHEMBL262628::indole sulfonamide, L Carbonic anhydrase 4 Homo sapiens 9000 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25904&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TUO 3B4F 14611919 56413192 CHEMBL262628 DB08659 ZINC24959962 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46960 Cc1ccccc1-c1c([nH]c2ccc(cc12)S(N)(=O)=O)C(=O)NN InChI=1S/C16H16N4O3S/c1-9-4-2-3-5-11(9)14-12-8-10(24(18,22)23)6-7-13(12)19-15(14)16(21)20-17/h2-8,19H,17H2,1H3,(H,20,21)(H2,18,22,23) PPSRAFWOBCBARB-UHFFFAOYSA-N 25905 2-(hydrazinecarbonyl)-3-(2-methylphenyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2a::indole sulfonamide, 8a Carbonic anhydrase 4 Homo sapiens 9096 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25905&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093413 56413193 ZINC40834921 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46961 Cc1cccc(c1)-c1c([nH]c2ccc(cc12)S(N)(=O)=O)C(=O)NN InChI=1S/C16H16N4O3S/c1-9-3-2-4-10(7-9)14-12-8-11(24(18,22)23)5-6-13(12)19-15(14)16(21)20-17/h2-8,19H,17H2,1H3,(H,20,21)(H2,18,22,23) GHJDGICRKYVOER-UHFFFAOYSA-N 25906 2-(hydrazinecarbonyl)-3-(3-methylphenyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2b::indole sulfonamide, 8b Carbonic anhydrase 4 Homo sapiens 7760 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25906&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093414 56413194 ZINC40918262 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46962 Cc1ccc(cc1)-c1c([nH]c2ccc(cc12)S(N)(=O)=O)C(=O)NN InChI=1S/C16H16N4O3S/c1-9-2-4-10(5-3-9)14-12-8-11(24(18,22)23)6-7-13(12)19-15(14)16(21)20-17/h2-8,19H,17H2,1H3,(H,20,21)(H2,18,22,23) ASTGOBQPJUODSJ-UHFFFAOYSA-N 25907 2-(hydrazinecarbonyl)-3-(4-methylphenyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2c::indole sulfonamide, 8c Carbonic anhydrase 4 Homo sapiens 3035 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25907&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093415 56413195 ZINC40918426 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46963 NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1F)S(N)(=O)=O InChI=1S/C15H13FN4O3S/c16-11-4-2-1-3-9(11)13-10-7-8(24(18,22)23)5-6-12(10)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23) MHRXBUANTJMUAD-UHFFFAOYSA-N 25908 3-(2-fluorophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2d::indole sulfonamide, 8d Carbonic anhydrase 4 Homo sapiens 9500 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25908&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093416 56413196 ZINC40404591 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46964 NNC(=O)c1[nH]c2ccc(cc2c1-c1cccc(F)c1)S(N)(=O)=O InChI=1S/C15H13FN4O3S/c16-9-3-1-2-8(6-9)13-11-7-10(24(18,22)23)4-5-12(11)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23) GNJGQRSFMGSXGK-UHFFFAOYSA-N 25909 3-(3-fluorophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2e::indole sulfonamide, 8e Carbonic anhydrase 4 Homo sapiens 6260 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25909&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093417 56413197 ZINC40917210 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46965 NNC(=O)c1[nH]c2ccc(cc2c1-c1ccc(F)cc1)S(N)(=O)=O InChI=1S/C15H13FN4O3S/c16-9-3-1-8(2-4-9)13-11-7-10(24(18,22)23)5-6-12(11)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23) RKJALVWPURNLMT-UHFFFAOYSA-N 25910 3-(4-fluorophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2f::indole sulfonamide, 8f Carbonic anhydrase 4 Homo sapiens 3650 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25910&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093418 56413198 ZINC40420446 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46966 NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1Cl)S(N)(=O)=O InChI=1S/C15H13ClN4O3S/c16-11-4-2-1-3-9(11)13-10-7-8(24(18,22)23)5-6-12(10)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23) POTAERZUCKEKBH-UHFFFAOYSA-N 25911 3-(2-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2g::indole sulfonamide, 8g Carbonic anhydrase 4 Homo sapiens 8680 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25911&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093419 56413199 ZINC40918897 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46967 NNC(=O)c1[nH]c2ccc(cc2c1-c1cccc(Cl)c1)S(N)(=O)=O InChI=1S/C15H13ClN4O3S/c16-9-3-1-2-8(6-9)13-11-7-10(24(18,22)23)4-5-12(11)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23) RCWSBQCWRNEOFW-UHFFFAOYSA-N 25912 3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2h::indole sulfonamide, 8h Carbonic anhydrase 4 Homo sapiens 6140 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25912&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093420 56413200 ZINC40918623 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46968 NNC(=O)c1[nH]c2ccc(cc2c1-c1ccc(Cl)cc1)S(N)(=O)=O InChI=1S/C15H13ClN4O3S/c16-9-3-1-8(2-4-9)13-11-7-10(24(18,22)23)5-6-12(11)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23) MWNVWAXIPABVDF-UHFFFAOYSA-N 25913 3-(4-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2i::indole sulfonamide, 8i Carbonic anhydrase 4 Homo sapiens 4030 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25913&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093421 56413201 ZINC40917873 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46969 NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1Br)S(N)(=O)=O InChI=1S/C15H13BrN4O3S/c16-11-4-2-1-3-9(11)13-10-7-8(24(18,22)23)5-6-12(10)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23) XQBLSLMDDOHBFU-UHFFFAOYSA-N 25914 3-(2-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2j::indole sulfonamide, 8j Carbonic anhydrase 4 Homo sapiens 7325 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25914&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093422 56413202 ZINC40973754 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46970 NNC(=O)c1[nH]c2ccc(cc2c1-c1cccc(Br)c1)S(N)(=O)=O InChI=1S/C15H13BrN4O3S/c16-9-3-1-2-8(6-9)13-11-7-10(24(18,22)23)4-5-12(11)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23) LOUMFRZBAXRSLT-UHFFFAOYSA-N 25915 3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2k::indole sulfonamide, 8k Carbonic anhydrase 4 Homo sapiens 5525 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25915&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093423 56413203 ZINC40918021 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46971 NNC(=O)c1[nH]c2ccc(cc2c1-c1ccc(Br)cc1)S(N)(=O)=O InChI=1S/C15H13BrN4O3S/c16-9-3-1-8(2-4-9)13-11-7-10(24(18,22)23)5-6-12(11)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23) CEIRDSOBQYEQJL-UHFFFAOYSA-N 25916 3-(4-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2l::indole sulfonamide, 8l Carbonic anhydrase 4 Homo sapiens 2912 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25916&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093424 56413204 ZINC40916312 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46972 COc1cccc(c1)-c1c([nH]c2ccc(cc12)S(N)(=O)=O)C(=O)NN InChI=1S/C16H16N4O4S/c1-24-10-4-2-3-9(7-10)14-12-8-11(25(18,22)23)5-6-13(12)19-15(14)16(21)20-17/h2-8,19H,17H2,1H3,(H,20,21)(H2,18,22,23) XMVMNUZFCYFGLW-UHFFFAOYSA-N 25917 2-(hydrazinecarbonyl)-3-(3-methoxyphenyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2m::indole sulfonamide, 8m Carbonic anhydrase 4 Homo sapiens 5740 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25917&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093425 56413205 ZINC40916659 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 46973 NNC(=O)c1[nH]c2ccc(cc2c1-c1c(F)c(F)c(F)c(F)c1F)S(N)(=O)=O InChI=1S/C15H9F5N4O3S/c16-9-8(10(17)12(19)13(20)11(9)18)7-5-3-4(28(22,26)27)1-2-6(5)23-14(7)15(25)24-21/h1-3,23H,21H2,(H,24,25)(H2,22,26,27) AWDKBDAWOHYQRV-UHFFFAOYSA-N 25918 2-(hydrazinecarbonyl)-3-(2,3,4,5,6-pentafluorophenyl)-1H-indole-5-sulfonamide::BMC173212 Compound 2n::indole sulfonamide, 8n Carbonic anhydrase 4 Homo sapiens 5215 Curated from the literature by BindingDB 10.1016/j.bmc.2008.09.032 10.7270/Q2ZW1J7D 18819811 aid1798603 Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Istanbul University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25918&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25093426 56413206 ZINC40918909 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 59506 CCCCCCCCOS(N)(=O)=O InChI=1S/C8H19NO3S/c1-2-3-4-5-6-7-8-12-13(9,10)11/h2-8H2,1H3,(H2,9,10,11) ZXWAFSSPWCHAJT-UHFFFAOYSA-N 33279 CHEMBL24261::aliphatic sulfamate, 1 Carbonic anhydrase 4 Homo sapiens 79.9 7.5 23.00 C Curated from the literature by BindingDB 10.1021/jm900641r 10.7270/Q2GF0RVR 19731956 aid1799232 Vitale, RM; Alterio, V; Innocenti, A; Winum, JY; Monti, SM; De Simone, G; Supuran, CT CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=33279&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BOW 3IBI 11117301 85266898 CHEMBL24261 ZINC34717916 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 59507 CCCCCCCCCCOS(N)(=O)=O InChI=1S/C10H23NO3S/c1-2-3-4-5-6-7-8-9-10-14-15(11,12)13/h2-10H2,1H3,(H2,11,12,13) JBKMRMOTMJVNML-UHFFFAOYSA-N 33280 CHEMBL153094::aliphatic sulfamate, 2 Carbonic anhydrase 4 Homo sapiens 67.6 7.5 23.00 C Curated from the literature by BindingDB 10.1021/jm900641r 10.7270/Q2GF0RVR 19731956 aid1799232 Vitale, RM; Alterio, V; Innocenti, A; Winum, JY; Monti, SM; De Simone, G; Supuran, CT CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=33280&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search O48 3IBU 19772348 85266899 CHEMBL153094 ZINC34718172 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 59508 NS(=O)(=O)OCCCCCCCCOS(N)(=O)=O InChI=1S/C8H20N2O6S2/c9-17(11,12)15-7-5-3-1-2-4-6-8-16-18(10,13)14/h1-8H2,(H2,9,11,12)(H2,10,13,14) IPTXSYCLIWBHBX-UHFFFAOYSA-N 33281 CHEMBL182455::bis-sulfamate, 3 Carbonic anhydrase 4 Homo sapiens 84.1 7.5 23.00 C Curated from the literature by BindingDB 10.1021/jm900641r 10.7270/Q2GF0RVR 19731956 aid1799232 Vitale, RM; Alterio, V; Innocenti, A; Winum, JY; Monti, SM; De Simone, G; Supuran, CT CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=33281&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search O59 3IBL 20043772 85266900 CHEMBL182455 ZINC28358893 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 59509 NS(=O)(=O)OCCCCCCCCCCOS(N)(=O)=O InChI=1S/C10H24N2O6S2/c11-19(13,14)17-9-7-5-3-1-2-4-6-8-10-18-20(12,15)16/h1-10H2,(H2,11,13,14)(H2,12,15,16) XPDWKENHTJHZSC-UHFFFAOYSA-N 33282 CHEMBL171476::bis-sulfamate, 4 Carbonic anhydrase 4 Homo sapiens 91.2 7.5 23.00 C Curated from the literature by BindingDB 10.1021/jm900641r 10.7270/Q2GF0RVR 19731956 aid1799232 Vitale, RM; Alterio, V; Innocenti, A; Winum, JY; Monti, SM; De Simone, G; Supuran, CT CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=33282&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search O60 3IBN 148885 85266901 CHEMBL171476 ZINC05113104 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 59510 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 7.5 23.00 C Curated from the literature by BindingDB 10.1021/jm900641r 10.7270/Q2GF0RVR 19731956 aid1799232 Vitale, RM; Alterio, V; Innocenti, A; Winum, JY; Monti, SM; De Simone, G; Supuran, CT CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 59511 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 IAVUPMFITXYVAF-XPUUQOCRSA-N 10884 (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide::Dorzolamide (DRZ)::Dorzolamide (DZA) Carbonic anhydrase 4 Homo sapiens 8500 7.5 23.00 C Curated from the literature by BindingDB 10.1021/jm900641r 10.7270/Q2GF0RVR 19731956 aid1799232 Vitale, RM; Alterio, V; Innocenti, A; Winum, JY; Monti, SM; De Simone, G; Supuran, CT CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10884&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ETS 4M2W,4M2U,4K13,3FW3,6BC9,1CIL 5284549 46511454 4702 DB00869 6810 C06969 ZINC01530621 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 159033 NS(=O)(=O)Cc1noc2ccccc12 InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12) UBQNRHZMVUUOMG-UHFFFAOYSA-N 10888 1,2-benzoxazol-3-ylmethanesulfonamide::CHEMBL750::SPR_2::US10172837, Zonisamide::Zonisamide::Zonisamide (ZNA)::Zonisamide (ZNS)::Zonisamide, 1::Zonisamide, ZNS Carbonic anhydrase 4 Homo sapiens 8590 7.5 20.00 C Curated from the literature by BindingDB 10.1111/j.1747-0285.2009.00857.x 10.7270/Q2833QHP 19703035 aid1799588 De Simone, G; Scozzafava, A; Supuran, CT Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10888&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ZON 3PO7 5734 46511458 10127 CHEMBL750 DB00909 7047 C07504 ZINC00004321 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 159045 NS(=O)(=O)c1ccc(cc1)N1CCCCS1(=O)=O InChI=1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16) HMHVCUVYZFYAJI-UHFFFAOYSA-N 26999 4-(1,1-dioxo-1,2-thiazinan-2-yl)benzene-1-sulfonamide::CHEMBL328560::Contravul::Ospolot::Sulthiame (SLT)::Sulthiame, 2 Carbonic anhydrase 4 Homo sapiens 95 7.5 20.00 C Curated from the literature by BindingDB 10.1111/j.1747-0285.2009.00857.x 10.7270/Q2833QHP 19703035 aid1799588 De Simone, G; Scozzafava, A; Supuran, CT Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26999&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search OSP 2Q1Q 5356 57298709 CHEMBL328560 DB08329 ZINC00002119 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 159057 CC1(C)O[C@@H]2CC[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C13H23NO7S/c1-11(2)18-8-5-6-13(7-17-22(14,15)16)10(9(8)19-11)20-12(3,4)21-13/h8-10H,5-7H2,1-4H3,(H2,14,15,16)/t8-,9-,10+,13+/m1/s1 DIISHYBDWUTJIE-DNJQJEMRSA-N 50210256 CHEMBL26300::Sulfamic acid (3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-benzo[1,2-d;3,4-d']bis[1,3]dioxol-3a-ylmethyl ester::Topiramate, 3 Carbonic anhydrase 4 Homo sapiens 4900 7.5 20.00 C Curated from the literature by BindingDB 10.1111/j.1747-0285.2009.00857.x 10.7270/Q2833QHP 19703035 aid1799588 De Simone, G; Scozzafava, A; Supuran, CT Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50210256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50210256&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 9797897 104086817 CHEMBL26300 ZINC03812398 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 159069 NS(=O)(=O)c1nnc(NC(=O)[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)s1 InChI=1S/C13H18N4O3S2/c14-22(19,20)12-17-16-11(21-12)15-10(18)13-4-7-1-8(5-13)3-9(2-7)6-13/h7-9H,1-6H2,(H2,14,19,20)(H,15,16,18)/t7-,8+,9-,13- NBKDQESIWDNDOT-LZFPZTGBSA-N 82103 Investigational agent, 4 Carbonic anhydrase 4 Homo sapiens 56 7.5 20.00 C Curated from the literature by BindingDB 10.1111/j.1747-0285.2009.00857.x 10.7270/Q2833QHP 19703035 aid1799588 De Simone, G; Scozzafava, A; Supuran, CT Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82103&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ARZ 7JOC,3MHC 394897 131342677 ZINC05839050 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 159081 NS(=O)(=O)c1nnc(NC(=O)N[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)s1 InChI=1S/C13H19N5O3S2/c14-23(20,21)12-18-17-11(22-12)15-10(19)16-13-4-7-1-8(5-13)3-9(2-7)6-13/h7-9H,1-6H2,(H2,14,20,21)(H2,15,16,17,19)/t7-,8+,9-,13- AFYZTZHCJDEWBD-LZFPZTGBSA-N 82104 Investigational agent, 5 Carbonic anhydrase 4 Homo sapiens 30 7.5 20.00 C Curated from the literature by BindingDB 10.1111/j.1747-0285.2009.00857.x 10.7270/Q2833QHP 19703035 aid1799588 De Simone, G; Scozzafava, A; Supuran, CT Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82104&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 54592380 131342678 ZINC87721914 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 180661 NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccccc2)s1 InChI=1S/C8H8N4O4S3/c9-18(13,14)8-11-10-7(17-8)12-19(15,16)6-4-2-1-3-5-6/h1-5H,(H,10,12)(H2,9,13,14) PWDGTQXZLNDOKS-UHFFFAOYSA-N 10886 2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide::BZA1::Benzolamide::Benzolamide (BZA)::CHEMBL73962 Carbonic anhydrase 4 Homo sapiens 12 7.4 20.00 C Curated from the literature by BindingDB 10.1080/14756360410001689559 10.7270/Q20C4TBB 15499999 aid1799673 Supuran, CT; Scozzafava, A Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10886&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3DB 3D8W,3DBU 18794 46511456 CHEMBL73962 DB07050 6920 ZINC04194731 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 180662 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 220 7.4 20.00 C Curated from the literature by BindingDB 10.1080/14756360410001689559 10.7270/Q20C4TBB 15499999 aid1799673 Supuran, CT; Scozzafava, A Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 180663 CC(=O)N=c1sc(nn1C)S(N)(=O)=O InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) FLOSMHQXBMRNHR-UHFFFAOYSA-N 10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid_4100::sulfonamide 2 Carbonic anhydrase 4 Homo sapiens 240 7.4 20.00 C Curated from the literature by BindingDB 10.1080/14756360410001689559 10.7270/Q20C4TBB 15499999 aid1799673 Supuran, CT; Scozzafava, A Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10881&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search MZM 4K0Z,4YHA,5KU6,1BZM,5C8I,3DAZ,3DCS 4100 46511451 CHEMBL288100 6828 ZINC12503151 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 180664 CCOc1ccc2nc(sc2c1)C(=O)ON InChI=1S/C10H10N2O3S/c1-2-14-6-3-4-7-8(5-6)16-9(12-7)10(13)15-11/h3-5H,2,11H2,1H3 KYEDSYGQLUWFDF-UHFFFAOYSA-N 85658 EZA4 Carbonic anhydrase 4 Homo sapiens 13 7.4 20.00 C Curated from the literature by BindingDB 10.1080/14756360410001689559 10.7270/Q20C4TBB 15499999 aid1799673 Supuran, CT; Scozzafava, A Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85658&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57340226 136351758 ZINC89456513 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 180665 NOC(=O)c1cc(Cl)c(Cl)c(c1)C(=O)ON InChI=1S/C8H6Cl2N2O4/c9-5-2-3(7(13)15-11)1-4(6(5)10)8(14)16-12/h1-2H,11-12H2 SSHMODVPGQFZJQ-UHFFFAOYSA-N 85659 DCP5 Carbonic anhydrase 4 Homo sapiens 120 7.4 20.00 C Curated from the literature by BindingDB 10.1080/14756360410001689559 10.7270/Q20C4TBB 15499999 aid1799673 Supuran, CT; Scozzafava, A Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85659&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57340227 136351759 ZINC87723001 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 410589 O[C@@H]1CC=CC[C@H]1OS(O)(=O)=O InChI=1S/C6H10O5S/c7-5-3-1-2-4-6(5)11-12(8,9)10/h1-2,5-7H,3-4H2,(H,8,9,10)/t5-,6-/m1/s1 WTIVAEIZODUDOZ-PHDIDXHHSA-N 235706 trans-(1R(S),6R(S))-6-Hydroxycyclohex-3-enyl hydrogen sulfate (4) Carbonic anhydrase 4 Homo sapiens 13700 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.629198 10.7270/Q2M907JC 22050606 aid1803044 Cavdar, H; Ekinci, D; Talaz, O; Saraçoglu, N; Sentürk, M; Supuran, CT Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235706&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129012250 340129299 C02000 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 410590 O[C@@H]1CC=CC[C@H]1O InChI=1S/C6H10O2/c7-5-3-1-2-4-6(5)8/h1-2,5-8H,3-4H2/t5-,6-/m1/s1 NWVFBFHOQGKOIF-PHDIDXHHSA-N 235707 (1R,2R)-cyclohexane-1,2-diol (5) Carbonic anhydrase 4 Homo sapiens 23600 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.629198 10.7270/Q2M907JC 22050606 aid1803044 Cavdar, H; Ekinci, D; Talaz, O; Saraçoglu, N; Sentürk, M; Supuran, CT Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235707&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11274988 340129300 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 410591 O[C@@H]1CC\C=C/CC[C@H]1OS(O)(=O)=O InChI=1S/C8H14O5S/c9-7-5-3-1-2-4-6-8(7)13-14(10,11)12/h1-2,7-9H,3-6H2,(H,10,11,12)/b2-1-/t7-,8-/m1/s1 FITMIEGKAHXPER-LQKKCHKWSA-N 235708 trans-(1R(S),8R(S),Z)-8-Hydroxycyclooct-4-enyl hydrogen sulfate (6) Carbonic anhydrase 4 Homo sapiens 16300 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.629198 10.7270/Q2M907JC 22050606 aid1803044 Cavdar, H; Ekinci, D; Talaz, O; Saraçoglu, N; Sentürk, M; Supuran, CT Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235708&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129012251 340129301 C02000 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 410592 O[C@@H]1CC\C=C/CC[C@H]1O InChI=1S/C8H14O2/c9-7-5-3-1-2-4-6-8(7)10/h1-2,7-10H,3-6H2/b2-1-/t7-,8-/m1/s1 JWEYNDRAHPIRPI-LQKKCHKWSA-N 235709 (2R,3R)-1,2,3,4-tetrahydronaphthalene-2,3-diol (7) Carbonic anhydrase 4 Homo sapiens 53800 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.629198 10.7270/Q2M907JC 22050606 aid1803044 Cavdar, H; Ekinci, D; Talaz, O; Saraçoglu, N; Sentürk, M; Supuran, CT Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235709&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11094725 340129302 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 410593 O[C@@H]1C2C[C@H](OS(O)(=O)=O)C1c1ccccc21 InChI=1S/C11H12O5S/c12-11-8-5-9(16-17(13,14)15)10(11)7-4-2-1-3-6(7)8/h1-4,8-12H,5H2,(H,13,14,15)/t8?,9-,10?,11+/m0/s1 JEOWJRHSXUQPAX-QONHTCSSSA-N 235710 9(R(S))-Hydroxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-2(R(S))-yl sulfate (8) Carbonic anhydrase 4 Homo sapiens 199000 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.629198 10.7270/Q2M907JC 22050606 aid1803044 Cavdar, H; Ekinci, D; Talaz, O; Saraçoglu, N; Sentürk, M; Supuran, CT Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235710&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129012252 340129303 C02000 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 410594 O[C@H]1CC2[C@@H](O)C1c1ccccc21 InChI=1S/C11H12O2/c12-9-5-8-6-3-1-2-4-7(6)10(9)11(8)13/h1-4,8-13H,5H2/t8?,9-,10?,11+/m0/s1 IJYOWIYFUHTPRX-QONHTCSSSA-N 235711 9(R(S))-Hydroxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-2(R(S))-diol (9) Carbonic anhydrase 4 Homo sapiens 234000 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.629198 10.7270/Q2M907JC 22050606 aid1803044 Cavdar, H; Ekinci, D; Talaz, O; Saraçoglu, N; Sentürk, M; Supuran, CT Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235711&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129012253 340129304 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 410595 O[C@@H]1CCCC[C@H]1O InChI=1S/C6H12O2/c7-5-3-1-2-4-6(5)8/h5-8H,1-4H2/t5-,6-/m1/s1 PFURGBBHAOXLIO-PHDIDXHHSA-N 36071 (1R,2R)-trans-1,2-cyclohexanediol::trans-(1R(S),2R(S))-cyclohexane-1,2-diol (10) Carbonic anhydrase 4 Homo sapiens 18800 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.629198 10.7270/Q2M907JC 22050606 aid1803044 Cavdar, H; Ekinci, D; Talaz, O; Saraçoglu, N; Sentürk, M; Supuran, CT Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36071&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 40O 5TND,4XDV 92886 103147718 16931 C03739 ZINC00157937 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 410596 O[C@@H]1Cc2ccccc2C[C@H]1O InChI=1S/C10H12O2/c11-9-5-7-3-1-2-4-8(7)6-10(9)12/h1-4,9-12H,5-6H2/t9-,10-/m1/s1 DHTGPMXCRKCPTP-NXEZZACHSA-N 235712 trans-(2R(S),3R(S))-1,2,3,4-Tetrahydronaphthalene-2,3-diol (11) Carbonic anhydrase 4 Homo sapiens 77900 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.629198 10.7270/Q2M907JC 22050606 aid1803044 Cavdar, H; Ekinci, D; Talaz, O; Saraçoglu, N; Sentürk, M; Supuran, CT Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=235712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=235712&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11805090 340129305 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 410597 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 5640 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.629198 10.7270/Q2M907JC 22050606 aid1803044 Cavdar, H; Ekinci, D; Talaz, O; Saraçoglu, N; Sentürk, M; Supuran, CT Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413499 CS(=O)(=O)Oc1ccccc1 InChI=1S/C7H8O3S/c1-11(8,9)10-7-5-3-2-4-6-7/h2-6H,1H3 WXVUCMFEGJUVTN-UHFFFAOYSA-N 237292 Phenylmethanesulfonate (4) Carbonic anhydrase 4 Homo sapiens 1.543e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237292&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 316170 340130852 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413500 CS(=O)(=O)Oc1ccc(cc1)-c1ccccc1 InChI=1S/C13H12O3S/c1-17(14,15)16-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-10H,1H3 CDSJENFSVVSOLZ-UHFFFAOYSA-N 237293 Biphenyl-4-ylmethanesulfonate (5) Carbonic anhydrase 4 Homo sapiens 2.648e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237293&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7313953 340130853 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413501 CS(=O)(=O)Oc1ccc(OS(C)(=O)=O)cc1 InChI=1S/C8H10O6S2/c1-15(9,10)13-7-3-5-8(6-4-7)14-16(2,11)12/h3-6H,1-2H3 BJOJAFLAKYWAAQ-UHFFFAOYSA-N 237294 1,4-Phenylene dimethanesulfonate (6) Carbonic anhydrase 4 Homo sapiens 9.12e+3 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237294&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1712528 340130854 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413502 Oc1ccccc1 InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H ISWSIDIOOBJBQZ-UHFFFAOYSA-N 26187 α-CA inhibitor, 11::CHEMBL14060::US9688816, 2::phenol Carbonic anhydrase 4 Homo sapiens 9.7e+3 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26187&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IPH 2PZV,3NX8,1XDA,4OLA,1MPJ,1PN0,5HPU,7AT0,1XW7,3AIY,3NC0,5USS,1JHY,1JHX,1WAV,2OMB,2OMN,3ROV,1FOH,5KI6,4W5Q,4W5R,4W5T,4W5N,1Q4V,4W5O,5URU,5JS1,5JS2,3ZS2,1XU5,6IY8,1AIY,5UU4,5UU3,6MFN,6MFR,1LI2,3Q3O,7JP3,3V1G,3V19,3JSD,5AIY,6Q7S,4A71,5FRW,2OLD,3ZQR,6TYH,3KQ6,3P2X,4JMW,5KBE,2WS6,2WS7,2J9N,1ZNJ,6MDZ,5ILG,1V03,7WDG,7WDH,1RWE,3KMH,4Z4F,4Z4G,4Z4D,4Z4E,4Z4C,4Z4H,4Z4I,1QIY,5BQQ,4F3T,1ZEG,6CK2,5W3R,4AIY,7VQF,1FJW,3GKY,4P65,5NQ8,1W8P,3U3E,5EMS,4AJZ,5T7B,3F39,4H07,4I7L,1AI0,1AI7,4AKJ,2AIY,2VE7,5HRQ,3GUO,5UDP,5WEA,4HDS,5UQA,2AS3,3P33,1LPH,6Z44 996 56464624 15882 CHEMBL14060 DB03255 C00146 ZINC05133329 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413503 Oc1ccc(cc1)-c1ccccc1 InChI=1S/C12H10O/c13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9,13H YXVFYQXJAXKLAK-UHFFFAOYSA-N 50149238 4-Hydroxybiphenyl::4-Phenylphenol::4-biphenylol::4-diphenylol::4-hydroxydiphenyl::Biphenyl-4-ol (8)::CHEMBL73380::[1,1'-biphenyl]-4-ol::biphenyl-4-ol::p-biphenylol::p-hydroxybiphenyl::p-hydroxydiphenyl::p-phenylphenol::para-hydroxydiphenyl::para-phenylphenol Carbonic anhydrase 4 Homo sapiens 1.234e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50149238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50149238&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7103 104037393 35447 CHEMBL73380 C14224 ZINC01510005 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413504 Oc1ccc(O)cc1 InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H QIGBRXMKCJKVMJ-UHFFFAOYSA-N 26190 1,4-Dihydroxybenzene, XIII::1,4-dihydroxybenzene::CHEMBL537::Hydroquinone (9)::Hydroquinone, HQ::benzene-1,4-diol::phenol derivative, 4 Carbonic anhydrase 4 Homo sapiens 1.08e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26190&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search HQE 4QOP,3ZOF,3ZOD,5I3B,7NNX,7NMP,7NIY,5FSE,4E3H,5I3A 785 56464627 17594 CHEMBL537 C00530 ZINC05133378 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413505 Oc1cccc(O)c1O InChI=1S/C6H6O3/c7-4-2-1-3-5(8)6(4)9/h1-3,7-9H WQGWDDDVZFFDIG-UHFFFAOYSA-N 50031472 1,2,3-Trihydroxybenzene, XIV::CHEMBL307145::Pyrogallol (10)::benzene-1,2,3-triol::pyrogallol Carbonic anhydrase 4 Homo sapiens 4.9e+2 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031472&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PYG 4QOM,3HHX,3O6R,4V4D 1057 103940103 16164 CHEMBL307145 C01108 ZINC00330141 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413506 CS(=O)(=O)Oc1cccc(OS(C)(=O)=O)c1OS(C)(=O)=O InChI=1S/C9H12O9S3/c1-19(10,11)16-7-5-4-6-8(17-20(2,12)13)9(7)18-21(3,14)15/h4-6H,1-3H3 YPPVLYIFEAESGO-UHFFFAOYSA-N 237295 Benzene-1,2,3-triyltrimethanesulfonate (11) Carbonic anhydrase 4 Homo sapiens 4.506e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237295&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 15333521 340130855 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413507 Oc1ccccc1O InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H YCIMNLLNPGFGHC-UHFFFAOYSA-N 26188 α-CA inhibitor, 12::1,2-Dihydroxybenzene, XI::1,2-dihydroxybenzene::CHEMBL280998::benzene-1,2-diol::phenol derivative, 2 Carbonic anhydrase 4 Homo sapiens 1.094e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26188&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CAQ 2BUY,2BUQ,4QON,3HHY,2PUM,4ZXT,5KBI,3O4M,6S2H,1DLT,5SWG,7WKM,7WKL,1XEP,3FW4,4K7I,7KK0,7WJR,3T67,7WMB,1KND,7BP1,5VXT,3MI5,5G4H,4OOW 289 56464625 18135 CHEMBL280998 DB02232 C00090 ZINC13512214 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413508 CS(=O)(=O)Oc1ccccc1OS(C)(=O)=O InChI=1S/C8H10O6S2/c1-15(9,10)13-7-5-3-4-6-8(7)14-16(2,11)12/h3-6H,1-2H3 DUTKQZIXCWCJHV-UHFFFAOYSA-N 237296 1,2-Phenylenedimethanesulfonate (13) Carbonic anhydrase 4 Homo sapiens 4.164e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237296&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 350468 340130856 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413509 COC1CC(CCC1O)C=O InChI=1S/C8H14O3/c1-11-8-4-6(5-9)2-3-7(8)10/h5-8,10H,2-4H2,1H3 DCDFGPPEPDQMPO-UHFFFAOYSA-N 237297 Vanillin (14) Carbonic anhydrase 4 Homo sapiens 1.84e+3 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237297&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10920778 340130857 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413510 COc1cc(C=O)ccc1OS(C)(=O)=O InChI=1S/C9H10O5S/c1-13-9-5-7(6-10)3-4-8(9)14-15(2,11)12/h3-6H,1-2H3 ZNASTXYIFMYILW-UHFFFAOYSA-N 237298 4-Formyl-2-methoxyphenyl methanesulfonate (15) Carbonic anhydrase 4 Homo sapiens 8.14e+3 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237298&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3650004 340130858 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413511 COc1ccccc1O InChI=1S/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H3 LHGVFZTZFXWLCP-UHFFFAOYSA-N 50240369 1-Hydroxy-2-methoxybenzene::2-Hydroxyanisole::2-methoxyphenol::CHEMBL13766::Guaiacol (16)::guaiacol Carbonic anhydrase 4 Homo sapiens 3.56e+3 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240369&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search JZ3 6HQK,6HQM,6HQL,6HQO,6HQN,6HQP,4QOQ,4A6Z,4A78,6KRF,5NCB,4G05,6YCJ,6YCH,6YCI,3HT9 460 104098252 28591 CHEMBL13766 C01502 ZINC13512224 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413512 CCOc1ccc2nc(CS(N)(=O)=O)sc2c1 InChI=1S/C10H12N2O3S2/c1-2-15-7-3-4-8-9(5-7)16-10(12-8)6-17(11,13)14/h3-5H,2,6H2,1H3,(H2,11,13,14) DJRLYFZDUSSRBQ-UHFFFAOYSA-N 237299 Ethoxzolamide (EZA) Carbonic anhydrase 4 Homo sapiens 8.4e+2 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237299&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129012500 340130859 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413513 NS(=O)(=O)Cc1noc2ccccc12 InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12) UBQNRHZMVUUOMG-UHFFFAOYSA-N 10888 1,2-benzoxazol-3-ylmethanesulfonamide::CHEMBL750::SPR_2::US10172837, Zonisamide::Zonisamide::Zonisamide (ZNA)::Zonisamide (ZNS)::Zonisamide, 1::Zonisamide, ZNS Carbonic anhydrase 4 Homo sapiens 3.845e+4 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10888&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ZON 3PO7 5734 46511458 10127 CHEMBL750 DB00909 7047 C07504 ZINC00004321 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413514 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 578 Curated from the literature by BindingDB 10.3109/14756366.2011.637202 10.7270/Q2VH5MRR 22145694 aid1803139 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Agri Ibrahim Cecen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413563 Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H REFJWTPEDVJJIY-UHFFFAOYSA-N 7460 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate::CHEMBL50::Quercetin::Quercetin (10)::Quercetin (21)::Quercetin (Qur)::US11021454, Compound Quercetin::US9180183, Quercetin::med.21724, Compound 4 Carbonic anhydrase 4 Homo sapiens 13800 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.643303 10.7270/Q2QR4W1F 22168126 aid1803140 Ekinci, D; Karagoz, L; Ekinci, D; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7460&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search QUE 3BPT,2HCK,3LJ0,4LMU,5FLI,5FLJ,3CF8,4DFU,4MRA,4WNJ,2O3P,2MS6,5AUW,3BXX,6M89,3LM5,1GP6,6AWS,6QCN,6QCD,7VUM,6B1D,2N6C,1E8W,2C9Z,5XG4,5A4V,2UXH,1H1I,2JJ2,6TTA,6IJD,3NVY 5280343 11108251 16243 CHEMBL50 DB04216 5346 C00389 ZINC03869685 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413564 O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1 InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15+/m0/s1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 23416 α-CA inhibitor, 3::(+)-Catechin::(2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol::CHEMBL311498::Catechin::D-Catechin Carbonic anhydrase 4 Homo sapiens 5600 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.643303 10.7270/Q2QR4W1F 22168126 aid1803140 Ekinci, D; Karagoz, L; Ekinci, D; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23416&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search KXN 3I52,4C94,4C9I 9064 50091680 15600 CHEMBL311498 C06562 ZINC00119983 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413565 Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1 InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H KZNIFHPLKGYRTM-UHFFFAOYSA-N 7458 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one::5,7-dihydroxy-2-(4-hydroxyphenyl)-chromen-4-one::Apigenin::Apigenin (2)::Apigenin (3)::Apigenin (7)::Apigenin, 13::CHEMBL28::Naringenin, 18::US10278929, Apigenin::US11337935, Compound Apigenin::acs.jmedchem.1c00409_ST.789::cid_5280443::jm5b01461, Compound 90 Carbonic anhydrase 4 Homo sapiens 9100 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.643303 10.7270/Q2QR4W1F 22168126 aid1803140 Ekinci, D; Karagoz, L; Ekinci, D; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7458&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AGI 4HKK,4DGM,5I2H,5AUV,4DER,7D3A,3AMY,4WO0,3CF9,5UQT 5280443 11108249 18388 CHEMBL28 DB07352 4136 C01477 ZINC03871576 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413566 Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1 InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H IQPNAANSBPBGFQ-UHFFFAOYSA-N 7459 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one::CHEMBL151::Luteolin (27)::Luteolin (4)::acs.jmedchem.1c00409_ST.600::cid_5280445::luteolin::med.21724, Compound 3 Carbonic anhydrase 4 Homo sapiens 4400 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.643303 10.7270/Q2QR4W1F 22168126 aid1803140 Ekinci, D; Karagoz, L; Ekinci, D; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7459&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search LU2 4HKN,4QYA,6YA5,4DGN,5AUU,6M8A,4DEW,3SZ1,7D3B,7EBV,5II2,5NDF,4QXV 5280445 11108250 15864 CHEMBL151 5215 C01514 ZINC18185774 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413567 Oc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H YXOLAZRVSSWPPT-UHFFFAOYSA-N 26658 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopyran-4-one::2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one::2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone::2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one::2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one::CHEMBL28626::MLS000069618::Morin (19)::Morin (5)::Morin (Mor)::SMR000058259::cid_5281670::morin Carbonic anhydrase 4 Homo sapiens 15700 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.643303 10.7270/Q2QR4W1F 22168126 aid1803140 Ekinci, D; Karagoz, L; Ekinci, D; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26658&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search MRI 5AUY,8A0P,7E4B,6AE3,6TT8 5281670 57298370 75092 CHEMBL28626 411 C10105 ZINC03881558 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413568 Oc1ccccc1 InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H ISWSIDIOOBJBQZ-UHFFFAOYSA-N 26187 α-CA inhibitor, 11::CHEMBL14060::US9688816, 2::phenol Carbonic anhydrase 4 Homo sapiens 14300 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.643303 10.7270/Q2QR4W1F 22168126 aid1803140 Ekinci, D; Karagoz, L; Ekinci, D; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26187&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IPH 2PZV,3NX8,1XDA,4OLA,1MPJ,1PN0,5HPU,7AT0,1XW7,3AIY,3NC0,5USS,1JHY,1JHX,1WAV,2OMB,2OMN,3ROV,1FOH,5KI6,4W5Q,4W5R,4W5T,4W5N,1Q4V,4W5O,5URU,5JS1,5JS2,3ZS2,1XU5,6IY8,1AIY,5UU4,5UU3,6MFN,6MFR,1LI2,3Q3O,7JP3,3V1G,3V19,3JSD,5AIY,6Q7S,4A71,5FRW,2OLD,3ZQR,6TYH,3KQ6,3P2X,4JMW,5KBE,2WS6,2WS7,2J9N,1ZNJ,6MDZ,5ILG,1V03,7WDG,7WDH,1RWE,3KMH,4Z4F,4Z4G,4Z4D,4Z4E,4Z4C,4Z4H,4Z4I,1QIY,5BQQ,4F3T,1ZEG,6CK2,5W3R,4AIY,7VQF,1FJW,3GKY,4P65,5NQ8,1W8P,3U3E,5EMS,4AJZ,5T7B,3F39,4H07,4I7L,1AI0,1AI7,4AKJ,2AIY,2VE7,5HRQ,3GUO,5UDP,5WEA,4HDS,5UQA,2AS3,3P33,1LPH,6Z44 996 56464624 15882 CHEMBL14060 DB03255 C00146 ZINC05133329 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413569 Oc1cccc(O)c1 InChI=1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H GHMLBKRAJCXXBS-UHFFFAOYSA-N 26189 α-CA inhibitor, 13::1,3-Dihydroxybenzene, XII::1,3-dihydroxybenzene::CHEMBL24147::US9688816, 4::benzene-1,3-diol::phenol derivative, 3 Carbonic anhydrase 4 Homo sapiens 634000 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.643303 10.7270/Q2QR4W1F 22168126 aid1803140 Ekinci, D; Karagoz, L; Ekinci, D; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26189&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search RCO 2OLY,2OLZ,3ZU1,4QOO,4DM3,4E49,2OMH,2OMI,2OM0,2OM1,6GSG,3AQT,1EVR,1QIZ,4AJX,4Z10,2W44 5054 56464626 27810 CHEMBL24147 C01751 ZINC00002028 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413570 Oc1ccccc1O InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H YCIMNLLNPGFGHC-UHFFFAOYSA-N 26188 α-CA inhibitor, 12::1,2-Dihydroxybenzene, XI::1,2-dihydroxybenzene::CHEMBL280998::benzene-1,2-diol::phenol derivative, 2 Carbonic anhydrase 4 Homo sapiens 11900 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.643303 10.7270/Q2QR4W1F 22168126 aid1803140 Ekinci, D; Karagoz, L; Ekinci, D; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26188&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CAQ 2BUY,2BUQ,4QON,3HHY,2PUM,4ZXT,5KBI,3O4M,6S2H,1DLT,5SWG,7WKM,7WKL,1XEP,3FW4,4K7I,7KK0,7WJR,3T67,7WMB,1KND,7BP1,5VXT,3MI5,5G4H,4OOW 289 56464625 18135 CHEMBL280998 DB02232 C00090 ZINC13512214 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413571 CCOc1ccc2nc(sc2c1)S(N)(=O)=O InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) OUZWUKMCLIBBOG-UHFFFAOYSA-N 10882 6-ethoxy-1,3-benzothiazole-2-sulfonamide::CHEMBL18::Ethamide::Ethoxazolamide::Ethoxzolamide::Ethoxzolamide (EZA)::Ethoxzolamide, EZM::Sulfonamide, 3::US10172837, Ethoxyzolamide::sulfonamide 3 Carbonic anhydrase 4 Homo sapiens 840 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.643303 10.7270/Q2QR4W1F 22168126 aid1803140 Ekinci, D; Karagoz, L; Ekinci, D; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10882&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EZL 3DD0,5JN9,3CAJ,3MDZ,6BCC,3DCW,6QL2,5TT3,6MWI 3295 46511452 101096 CHEMBL18 DB00311 6814 ZINC00056721 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413572 NS(=O)(=O)Cc1noc2ccccc12 InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12) UBQNRHZMVUUOMG-UHFFFAOYSA-N 10888 1,2-benzoxazol-3-ylmethanesulfonamide::CHEMBL750::SPR_2::US10172837, Zonisamide::Zonisamide::Zonisamide (ZNA)::Zonisamide (ZNS)::Zonisamide, 1::Zonisamide, ZNS Carbonic anhydrase 4 Homo sapiens 38400 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.643303 10.7270/Q2QR4W1F 22168126 aid1803140 Ekinci, D; Karagoz, L; Ekinci, D; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10888&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ZON 3PO7 5734 46511458 10127 CHEMBL750 DB00909 7047 C07504 ZINC00004321 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413573 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 580 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.643303 10.7270/Q2QR4W1F 22168126 aid1803140 Ekinci, D; Karagoz, L; Ekinci, D; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413725 NS(=O)(=O)c1ccc(cc1)C(=O)NCCCN1CCOCC1 InChI=1S/C14H21N3O4S/c15-22(19,20)13-4-2-12(3-5-13)14(18)16-6-1-7-17-8-10-21-11-9-17/h2-5H,1,6-11H2,(H,16,18)(H2,15,19,20) LAOOSMTXTNZTDT-UHFFFAOYSA-N 237336 4-Sulfamoyl-N-(3-morpholinopropyl)benzamide (I-1) Carbonic anhydrase 4 Homo sapiens 611.1 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.649269 10.7270/Q2Z89B9N 22299577 aid1803149 Supuran, CT; Maresca, A; Gregán, F; Remko, M Università di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237336&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25060316 340130873 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413726 NS(=O)(=O)c1ccc(cc1)S(=O)(=O)NCCCN1CCOCC1 InChI=1S/C13H21N3O5S2/c14-22(17,18)12-2-4-13(5-3-12)23(19,20)15-6-1-7-16-8-10-21-11-9-16/h2-5,15H,1,6-11H2,(H2,14,17,18) CLQKLKMYYRXPTB-UHFFFAOYSA-N 237337 N-(3-morpholinopropyl)benzene-1,4-disulfonamide (I-2) Carbonic anhydrase 4 Homo sapiens 498.8 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.649269 10.7270/Q2Z89B9N 22299577 aid1803149 Supuran, CT; Maresca, A; Gregán, F; Remko, M Università di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237337&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25059530 340130874 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 413727 CCN(CC)CCOc1ccc(CNS(=O)(=O)c2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C19H27N3O5S2/c1-3-22(4-2)13-14-27-17-7-5-16(6-8-17)15-21-29(25,26)19-11-9-18(10-12-19)28(20,23)24/h5-12,21H,3-4,13-15H2,1-2H3,(H2,20,23,24) PYEXUAJSPJTTKJ-UHFFFAOYSA-N 237338 N-(4-diethylaminoethoxybenzyl)benzene-1,4-bis-sulfonamide (I-3) Carbonic anhydrase 4 Homo sapiens 507.9 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.649269 10.7270/Q2Z89B9N 22299577 aid1803149 Supuran, CT; Maresca, A; Gregán, F; Remko, M Università di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237338&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25059531 340130875 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 417495 Cc1ncc(n1CCOc1ccc2c(C)cc(=O)oc2c1)[N+]([O-])=O InChI=1S/C16H15N3O5/c1-10-7-16(20)24-14-8-12(3-4-13(10)14)23-6-5-18-11(2)17-9-15(18)19(21)22/h3-4,7-9H,5-6H2,1-2H3 DZSMNKZDRKEEQX-UHFFFAOYSA-N 239155 7-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-methylcoumarine (1a) Carbonic anhydrase 4 Homo sapiens >2.00e+5 7.5 4.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650692 10.7270/Q20Z726F 22299576 aid1803216 Bonneau, A; Maresca, A; Winum, JY; Supuran, CT Ecole Nationale Supérieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239155&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57387138 340132443 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 417496 Cc1ncc(n1CCOc1ccc2oc(=O)cc(C)c2c1)[N+]([O-])=O InChI=1S/C16H15N3O5/c1-10-7-16(20)24-14-4-3-12(8-13(10)14)23-6-5-18-11(2)17-9-15(18)19(21)22/h3-4,7-9H,5-6H2,1-2H3 HNNWVMYYQQKICE-UHFFFAOYSA-N 239156 6-O-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]-4-methylcoumarine (1b) Carbonic anhydrase 4 Homo sapiens >2.00e+5 7.5 4.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650692 10.7270/Q20Z726F 22299576 aid1803216 Bonneau, A; Maresca, A; Winum, JY; Supuran, CT Ecole Nationale Supérieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239156&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57387139 340132444 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 417497 Oc1ccc2cc(C#N)c(=O)oc2c1 InChI=1S/C10H5NO3/c11-5-7-3-6-1-2-8(12)4-9(6)14-10(7)13/h1-4,12H IJQYTHQDUDCJEQ-UHFFFAOYSA-N 50095994 3-Cyano-7-hydroxycoumarin (2)::7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile::CHEMBL150302 Carbonic anhydrase 4 Homo sapiens >2.00e+5 7.5 4.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650692 10.7270/Q20Z726F 22299576 aid1803216 Bonneau, A; Maresca, A; Winum, JY; Supuran, CT Ecole Nationale Supérieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50095994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50095994&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3QV 3QVV,3U3M,3U3O 5393173 103993600 CHEMBL150302 ZINC00058014 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 417498 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 7.5 4.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650692 10.7270/Q20Z726F 22299576 aid1803216 Bonneau, A; Maresca, A; Winum, JY; Supuran, CT Ecole Nationale Supérieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 417561 OC1C[C@@H](OCC2O[C@@H](Oc3c(oc4cc(O)cc(O)c4c3=O)-c3ccc(O)c(O)c3)[C@@H](O)C(O)[C@@H]2O)C(O)[C@@H](O)C1O InChI=1S/C27H30O16/c28-9-4-12(31)17-14(5-9)41-25(8-1-2-10(29)11(30)3-8)26(21(17)36)43-27-24(39)23(38)20(35)16(42-27)7-40-15-6-13(32)18(33)22(37)19(15)34/h1-5,13,15-16,18-20,22-24,27-35,37-39H,6-7H2/t13?,15-,16?,18?,19?,20-,22+,23?,24+,27+/m1/s1 DTNWFSFAYSXDCN-XJZMSXNVSA-N 239157 α-CA inhibitor, 2 Carbonic anhydrase 4 Homo sapiens 3.76e+3 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.651464 10.7270/Q2W66JQ2 22299585 aid1803217 Koz, ÿ; Ekinci, D; Perrone, A; Piacente, S; Alankus-Çaliskan, ÿ; Bedir, E; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239157&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129012665 340132445 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 417562 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1 InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 23417 α-CA inhibitor, 4::(-)-Epicatechin::(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol::Epicatechin::L-Epicatechin::cid_72276 Carbonic anhydrase 4 Homo sapiens 3.98e+3 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.651464 10.7270/Q2W66JQ2 22299585 aid1803217 Koz, ÿ; Ekinci, D; Perrone, A; Piacente, S; Alankus-Çaliskan, ÿ; Bedir, E; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23417&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 28E 6AWV,6AWT,6AX0,4MA6 72276 50091681 90 C09727 ZINC00119988 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 417563 Oc1ccc(cc1)C1CC(=O)c2c(O)cc(O)cc2O1 InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2 FTVWIRXFELQLPI-UHFFFAOYSA-N 19461 α-CA inhibitor, 5::5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one::CHEMBL32571::Naringenin::Naringenin (NAR)::naringetol::salipurpol Carbonic anhydrase 4 Homo sapiens 1.12e+3 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.651464 10.7270/Q2W66JQ2 22299585 aid1803217 Koz, ÿ; Ekinci, D; Perrone, A; Piacente, S; Alankus-Çaliskan, ÿ; Bedir, E; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19461&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search NAR 7DQM,6G8H,6F71,6SRA 932 46519482 50202 CHEMBL32571 ZINC00156701 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 417564 CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]1[C@@H](O)C[C@@]2(C)C3C[C@H](O[C@@H]4OC(CO)[C@@H](O)C(O)[C@@H]4O)C4[C@]5(C[C@@]35CC[C@]12C)CC[C@H](O[C@@H]1OC[C@@H](O)C(O)[C@@H]1O[C@@H]1OC[C@H](O)C(O)[C@@H]1O)C4(C)C InChI=1S/C46H76O18/c1-40(2)26(62-39-34(29(52)22(50)18-59-39)63-37-32(55)28(51)21(49)17-58-37)9-11-46-19-45(46)13-12-42(5)35(44(7)10-8-27(64-44)41(3,4)57)20(48)15-43(42,6)25(45)14-23(36(40)46)60-38-33(56)31(54)30(53)24(16-47)61-38/h20-39,47-57H,8-19H2,1-7H3/t20-,21-,22+,23-,24?,25?,26-,27-,28?,29?,30+,31?,32-,33-,34-,35-,36?,37-,38+,39-,42+,43-,44+,45-,46+/m0/s1 VDLLVXHQXOOBCW-BGNLQHEFSA-N 239159 α-CA inhibitor, 7 Carbonic anhydrase 4 Homo sapiens 2.41e+3 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.651464 10.7270/Q2W66JQ2 22299585 aid1803217 Koz, ÿ; Ekinci, D; Perrone, A; Piacente, S; Alankus-Çaliskan, ÿ; Bedir, E; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239159&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129012667 340132447 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 417565 CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]1[C@@H](O)C[C@@]2(C)C3C[C@H](O[C@@H]4OC(CO)[C@@H](O)C(O)[C@@H]4O)C4[C@]5(C[C@@]35CC[C@]12C)CC[C@H](O[C@@H]1OC[C@@H](O)C(O)[C@@H]1O)C4(C)C InChI=1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22?,23?,24-,25-,26?,27+,28?,29-,30-,31-,32?,33-,34+,37+,38-,39+,40-,41+/m0/s1 QMNWISYXSJWHRY-CDDJQPGQSA-N 239160 α-CA inhibitor, 8 Carbonic anhydrase 4 Homo sapiens 2.75e+3 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.651464 10.7270/Q2W66JQ2 22299585 aid1803217 Koz, ÿ; Ekinci, D; Perrone, A; Piacente, S; Alankus-Çaliskan, ÿ; Bedir, E; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239160&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129012668 340132448 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 417566 CC1(C)C[C@@H](O)[C@]2(C)CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O[C@@H]6OC([C@@H](O)C(O)[C@@H]6O[C@@H]6OC[C@@H](O)[C@H](O)C6O[C@@H]6OC(O)[C@H](O)[C@H](O)C6O)C(O)=O)[C@](C)(CO)C5CC[C@@]34C)C2C1 InChI=1S/C46H74O18/c1-41(2)16-21-20-8-9-24-43(4)12-11-26(44(5,19-47)23(43)10-13-46(24,7)45(20,6)15-14-42(21,3)25(49)17-41)60-40-35(30(53)29(52)33(61-40)36(56)57)63-39-34(27(50)22(48)18-59-39)62-38-32(55)28(51)31(54)37(58)64-38/h8,21-35,37-40,47-55,58H,9-19H2,1-7H3,(H,56,57)/t21?,22-,23?,24?,25-,26+,27+,28+,29+,30?,31-,32?,33?,34?,35+,37?,38-,39+,40-,42-,43+,44-,45-,46-/m1/s1 QKBICHOHZDWTSC-WCZWIZFYSA-N 239161 α-CA inhibitor, 9 Carbonic anhydrase 4 Homo sapiens 3.94e+3 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.651464 10.7270/Q2W66JQ2 22299585 aid1803217 Koz, ÿ; Ekinci, D; Perrone, A; Piacente, S; Alankus-Çaliskan, ÿ; Bedir, E; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239161&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129012669 340132449 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 417567 CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]1[C@@H](O)C[C@@]2(C)C3C[C@H](O[C@@H]4OC[C@@H](O)C(O)[C@@H]4O)C4[C@]5(C[C@@]35CC[C@]12C)CC[C@H](O[C@@H]1OC[C@@H](O)C(O)[C@@H]1O)C4(C)C InChI=1S/C40H66O13/c1-34(2)24(52-33-29(47)27(45)21(43)17-50-33)9-11-40-18-39(40)13-12-36(5)30(38(7)10-8-25(53-38)35(3,4)48)19(41)15-37(36,6)23(39)14-22(31(34)40)51-32-28(46)26(44)20(42)16-49-32/h19-33,41-48H,8-18H2,1-7H3/t19-,20+,21+,22-,23?,24-,25-,26?,27?,28-,29-,30-,31?,32-,33-,36+,37-,38+,39-,40+/m0/s1 NPKUPKNGMRUMDI-FQWFXRECSA-N 239162 α-CA inhibitor, 10 Carbonic anhydrase 4 Homo sapiens 4.36e+3 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.651464 10.7270/Q2W66JQ2 22299585 aid1803217 Koz, ÿ; Ekinci, D; Perrone, A; Piacente, S; Alankus-Çaliskan, ÿ; Bedir, E; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239162&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129012670 340132450 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 417568 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 578 7.4 Curated from the literature by BindingDB 10.3109/14756366.2011.651464 10.7270/Q2W66JQ2 22299585 aid1803217 Koz, ÿ; Ekinci, D; Perrone, A; Piacente, S; Alankus-Çaliskan, ÿ; Bedir, E; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 433057 C[C@@]1(O)CC23C[C@@H](O)[C@@]4(O)[C@@H](C[C@H](O)C4(C)C)[C@](C)(O)[C@@H]2CCC1[C@H]3O InChI=1S/C20H34O6/c1-16(2)13(21)7-12-18(4,25)11-6-5-10-15(23)19(11,9-17(10,3)24)8-14(22)20(12,16)26/h10-15,21-26H,5-9H2,1-4H3/t10?,11-,12-,13-,14+,15+,17+,18+,19?,20-/m0/s1 BWMFRQKICHXLSH-BTDHUSNTSA-N 248142 Grayanotoxin III (GTX3) Carbonic anhydrase 4 Homo sapiens 5.1e+2 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2013.804072 10.7270/Q24X56QZ 23914927 aid1803440 Durdagi, S; Scozzafava, G; Vullo, D; Sahin, H; Kolayli, S; Supuran, CT University of Calgary http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=248142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=248142&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 131635673 346542671 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 433069 NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) GJQPMPFPNINLKP-UHFFFAOYSA-N 10883 4,5-dichlorobenzene-1,3-disulfonamide::CHEMBL17::Dichlorophenamide::Dichlorophenamide (DCP)::Dichlorophenamide, DCP::Sulfonamide, 4::US10172837, Dichlorphenamide::sulfonamide 4 Carbonic anhydrase 4 Homo sapiens 1.50e+4 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2013.804072 10.7270/Q24X56QZ 23914927 aid1803440 Durdagi, S; Scozzafava, G; Vullo, D; Sahin, H; Kolayli, S; Supuran, CT University of Calgary http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10883&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search I7A 2POU 3038 46511453 101085 CHEMBL17 DB01144 6807 C07459 ZINC00896918 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50173805 NS(=O)(=O)c1ccc(CCNC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)NCCc2ccc(cc2)S(N)(=O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C30H43N7O12S2/c31-50(46,47)24-5-1-22(2-6-24)9-11-33-26(38)17-36(20-29(42)43)15-13-35(19-28(40)41)14-16-37(21-30(44)45)18-27(39)34-12-10-23-3-7-25(8-4-23)51(32,48)49/h1-8H,9-21H2,(H,33,38)(H,34,39)(H,40,41)(H,42,43)(H,44,45)(H2,31,46,47)(H2,32,48,49) GTBRQIOYGMBQQS-UHFFFAOYSA-N 50097277 ((2-{Carboxymethyl-[2-(carboxymethyl-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid::((2-{Carboxymethyl-[2-(carboxymethyl-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid;compound with Zn complex::CHEMBL1795062::CHEMBL286862::Zinc; ((2-{Carboxymethyl-[2-(carboxymethyl-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid Carbonic anhydrase 4 Homo sapiens 16 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097277&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11115351 103994609 CHEMBL286862CHEMBL1795062 ZINC95608819 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50174007 [Zn++].Cn1nc(s\c1=N\C(=O)CN(CCN(CCN(CC([O-])=O)CC(=O)\N=c1/sc(nn1C)S(N)(=O)=O)CC([O-])=O)CC(O)=O)S(N)(=O)=O InChI=1S/C20H31N11O12S4/c1-27-17(44-19(25-27)46(21,40)41)23-12(32)7-30(10-15(36)37)5-3-29(9-14(34)35)4-6-31(11-16(38)39)8-13(33)24-18-28(2)26-20(45-18)47(22,42)43/h3-11H2,1-2H3,(H,34,35)(H,36,37)(H,38,39)(H2,21,40,41)(H2,22,42,43)/p-2/b23-17-,24-18+ XBLYYDDTTORRLT-QFFDILLMSA-L 50219176 CHEMBL2111218 Carbonic anhydrase 4 Homo sapiens 5 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50219176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50219176&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 70689373 376225810 CHEMBL2111218 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50174008 [Zn++].NS(=O)(=O)c1nnc(NC(=O)CN(CCN(CCN(CC([O-])=O)CC(=O)Nc2nnc(s2)S(N)(=O)=O)CC([O-])=O)CC(O)=O)s1 InChI=1S/C18H27N11O12S4/c19-44(38,39)17-25-23-15(42-17)21-10(30)5-28(8-13(34)35)3-1-27(7-12(32)33)2-4-29(9-14(36)37)6-11(31)22-16-24-26-18(43-16)45(20,40)41/h1-9H2,(H,32,33)(H,34,35)(H,36,37)(H2,19,38,39)(H2,20,40,41)(H,21,23,30)(H,22,24,31)/p-2 ABKUNMXQTDTBPW-UHFFFAOYSA-L 50219174 CHEMBL2112274 Carbonic anhydrase 4 Homo sapiens 4 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50219174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50219174&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71450862 376225808 CHEMBL2112274 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50174012 [Zn++].NS(=O)(=O)c1ccc(CNC(=O)CN(CCN(CCN(CC([O-])=O)CC(=O)NCc2ccc(cc2)S(N)(=O)=O)CC([O-])=O)CC(O)=O)cc1 InChI=1S/C28H39N7O12S2/c29-48(44,45)22-5-1-20(2-6-22)13-31-24(36)15-34(18-27(40)41)11-9-33(17-26(38)39)10-12-35(19-28(42)43)16-25(37)32-14-21-3-7-23(8-4-21)49(30,46)47/h1-8H,9-19H2,(H,31,36)(H,32,37)(H,38,39)(H,40,41)(H,42,43)(H2,29,44,45)(H2,30,46,47)/p-2 RSPXQWLZLVDDAI-UHFFFAOYSA-L 50219173 CHEMBL2112276 Carbonic anhydrase 4 Homo sapiens 21 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50219173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50219173&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71449075 376225807 CHEMBL2112276 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50174014 [Zn++].NS(=O)(=O)c1ccc(NC(=O)CN(CCN(CCN(CC([O-])=O)CC(=O)Nc2ccc(cc2)S(N)(=O)=O)CC([O-])=O)CC(O)=O)cc1 InChI=1S/C26H35N7O12S2/c27-46(42,43)20-5-1-18(2-6-20)29-22(34)13-32(16-25(38)39)11-9-31(15-24(36)37)10-12-33(17-26(40)41)14-23(35)30-19-3-7-21(8-4-19)47(28,44)45/h1-8H,9-17H2,(H,29,34)(H,30,35)(H,36,37)(H,38,39)(H,40,41)(H2,27,42,43)(H2,28,44,45)/p-2 KPZSOSRRNOIKIF-UHFFFAOYSA-L 50219175 CHEMBL2112275 Carbonic anhydrase 4 Homo sapiens 100 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50219175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50219175&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71459903 376225809 CHEMBL2112275 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50082364 O=C1NS(=O)(=O)c2ccccc12 InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9) CVHZOJJKTDOEJC-UHFFFAOYSA-N 29278 CHEMBL310671::Garantose::SAC::Saccharimide::Saccharin Carbonic anhydrase 4 Homo sapiens 7920 ChEMBL 10.1021/jm500255y 10.7270/Q2NS0WF1 24689792 Moeker, J; Peat, TS; Bornaghi, LF; Vullo, D; Supuran, CT; Poulsen, SA Griffith University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29278&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search LSA 2Q38,7WJV,5RSP,4RIV,6FJJ,4N1O,3SRK,2Q1B 5143 81054707 32111 CHEMBL310671 5432 C12283 ZINC02560357 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50245730 NS(=O)(=O)c1c(F)c(F)c(c(NC2CCCCCCC2)c1F)S(=O)(=O)CCO InChI=1S/C16H23F3N2O5S2/c17-11-12(18)16(27(23,24)9-8-22)14(13(19)15(11)28(20,25)26)21-10-6-4-2-1-3-5-7-10/h10,21-22H,1-9H2,(H2,20,25,26) HFJJAVOBUVMVFQ-UHFFFAOYSA-N 50031588 CHEMBL3359181 Carbonic anhydrase 4 Homo sapiens 25 ChEMBL 10.1021/jm501003k 10.7270/Q280547S 25358084 Dudutiene, V; Matuliene, J; Smirnov, A; Timm, DD; Zubriene, A; Baranauskiene, L; Morkunaite, V; Smirnoviene, J; Michailoviene, V; Juozapaitiene, V; Mickeviciute, A; Kazokaite, J; Bakšyte, S; Kasiliauskaite, A; Jachno, J; Revuckiene, J; Kišonaite, M; Pilipuityte, V; Ivanauskaite, E; Milinaviciute, G; Smirnovas, V; Petrikaite, V; Kairys, V; Petrauskas, V; Norvaišas, P; Linge, D; Gibieža, P; Capkauskaite, E; Zakšauskas, A; Kazlauskas, E; Manakova, E; Gražulis, S; Ladbury, JE; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031588&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search V14 7NZT,6FE1,5E2M,5E2N,4Q0L,4Q07,4Q09,4PYY,6QL3,6RMY 73774785 313066081 CHEMBL3359181 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50245767 NS(=O)(=O)c1c(F)c(F)c(SCCO)c(F)c1F InChI=1S/C8H7F4NO3S2/c9-3-5(11)8(18(13,15)16)6(12)4(10)7(3)17-2-1-14/h14H,1-2H2,(H2,13,15,16) DKTDBVHOWVECPE-UHFFFAOYSA-N 50429899 CHEMBL2333416 Carbonic anhydrase 4 Homo sapiens 590 ChEMBL 10.1021/jm501003k 10.7270/Q280547S 25358084 Dudutiene, V; Matuliene, J; Smirnov, A; Timm, DD; Zubriene, A; Baranauskiene, L; Morkunaite, V; Smirnoviene, J; Michailoviene, V; Juozapaitiene, V; Mickeviciute, A; Kazokaite, J; Bakšyte, S; Kasiliauskaite, A; Jachno, J; Revuckiene, J; Kišonaite, M; Pilipuityte, V; Ivanauskaite, E; Milinaviciute, G; Smirnovas, V; Petrikaite, V; Kairys, V; Petrauskas, V; Norvaišas, P; Linge, D; Gibieža, P; Capkauskaite, E; Zakšauskas, A; Kazlauskas, E; Manakova, E; Gražulis, S; Ladbury, JE; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429899&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71584198 164158774 CHEMBL2333416 ZINC95591208 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50245852 NS(=O)(=O)c1c(F)c(F)c(SCCO)c(F)c1NC1CCCCCCC1 InChI=1S/C16H23F3N2O3S2/c17-11-12(18)16(26(20,23)24)14(13(19)15(11)25-9-8-22)21-10-6-4-2-1-3-5-7-10/h10,21-22H,1-9H2,(H2,20,23,24) ZUTOCUUMVDYVHW-UHFFFAOYSA-N 50031589 CHEMBL3359179 Carbonic anhydrase 4 Homo sapiens 1700 ChEMBL 10.1021/jm501003k 10.7270/Q280547S 25358084 Dudutiene, V; Matuliene, J; Smirnov, A; Timm, DD; Zubriene, A; Baranauskiene, L; Morkunaite, V; Smirnoviene, J; Michailoviene, V; Juozapaitiene, V; Mickeviciute, A; Kazokaite, J; Bakšyte, S; Kasiliauskaite, A; Jachno, J; Revuckiene, J; Kišonaite, M; Pilipuityte, V; Ivanauskaite, E; Milinaviciute, G; Smirnovas, V; Petrikaite, V; Kairys, V; Petrauskas, V; Norvaišas, P; Linge, D; Gibieža, P; Capkauskaite, E; Zakšauskas, A; Kazlauskas, E; Manakova, E; Gražulis, S; Ladbury, JE; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031589&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search V90 7NZR,6ROF,6FE0,5OGJ,4Q06,4Q08,4PYX 73776203 313066082 CHEMBL3359179 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50245879 NS(=O)(=O)c1c(F)c(F)c(SCCc2ccccc2)c(F)c1NC1CCCCCCCCCCC1 InChI=1S/C26H35F3N2O2S2/c27-21-22(28)26(35(30,32)33)24(23(29)25(21)34-18-17-19-13-9-8-10-14-19)31-20-15-11-6-4-2-1-3-5-7-12-16-20/h8-10,13-14,20,31H,1-7,11-12,15-18H2,(H2,30,32,33) VWMDRRXNOPHEJG-UHFFFAOYSA-N 50031587 CHEMBL3359180 Carbonic anhydrase 4 Homo sapiens >200000 ChEMBL 10.1021/jm501003k 10.7270/Q280547S 25358084 Dudutiene, V; Matuliene, J; Smirnov, A; Timm, DD; Zubriene, A; Baranauskiene, L; Morkunaite, V; Smirnoviene, J; Michailoviene, V; Juozapaitiene, V; Mickeviciute, A; Kazokaite, J; Bakšyte, S; Kasiliauskaite, A; Jachno, J; Revuckiene, J; Kišonaite, M; Pilipuityte, V; Ivanauskaite, E; Milinaviciute, G; Smirnovas, V; Petrikaite, V; Kairys, V; Petrauskas, V; Norvaišas, P; Linge, D; Gibieža, P; Capkauskaite, E; Zakšauskas, A; Kazlauskas, E; Manakova, E; Gražulis, S; Ladbury, JE; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031587&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 73776055 313066080 CHEMBL3359180 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50245915 NS(=O)(=O)c1c(F)c(F)c(c(F)c1F)S(=O)(=O)CCO InChI=1S/C8H7F4NO5S2/c9-3-5(11)8(20(13,17)18)6(12)4(10)7(3)19(15,16)2-1-14/h14H,1-2H2,(H2,13,17,18) WZGGLNWNBUCLIP-UHFFFAOYSA-N 50429900 CHEMBL2333417 Carbonic anhydrase 4 Homo sapiens 160 ChEMBL 10.1021/jm501003k 10.7270/Q280547S 25358084 Dudutiene, V; Matuliene, J; Smirnov, A; Timm, DD; Zubriene, A; Baranauskiene, L; Morkunaite, V; Smirnoviene, J; Michailoviene, V; Juozapaitiene, V; Mickeviciute, A; Kazokaite, J; Bakšyte, S; Kasiliauskaite, A; Jachno, J; Revuckiene, J; Kišonaite, M; Pilipuityte, V; Ivanauskaite, E; Milinaviciute, G; Smirnovas, V; Petrikaite, V; Kairys, V; Petrauskas, V; Norvaišas, P; Linge, D; Gibieža, P; Capkauskaite, E; Zakšauskas, A; Kazlauskas, E; Manakova, E; Gražulis, S; Ladbury, JE; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429900&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search V13 6YH4,4HU1,4PZH,7NZX,5MSB 71299337 164158775 CHEMBL2333417 ZINC95586323 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50245936 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 100 ChEMBL 10.1021/jm501003k 10.7270/Q280547S 25358084 Dudutiene, V; Matuliene, J; Smirnov, A; Timm, DD; Zubriene, A; Baranauskiene, L; Morkunaite, V; Smirnoviene, J; Michailoviene, V; Juozapaitiene, V; Mickeviciute, A; Kazokaite, J; Bakšyte, S; Kasiliauskaite, A; Jachno, J; Revuckiene, J; Kišonaite, M; Pilipuityte, V; Ivanauskaite, E; Milinaviciute, G; Smirnovas, V; Petrikaite, V; Kairys, V; Petrauskas, V; Norvaišas, P; Linge, D; Gibieža, P; Capkauskaite, E; Zakšauskas, A; Kazlauskas, E; Manakova, E; Gražulis, S; Ladbury, JE; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50258852 NS(=O)(=O)c1ccc(CNC(=O)CCCNC(=O)Nc2ccccc2)cc1 InChI=1S/C18H22N4O4S/c19-27(25,26)16-10-8-14(9-11-16)13-21-17(23)7-4-12-20-18(24)22-15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-13H2,(H,21,23)(H2,19,25,26)(H2,20,22,24) RAJOFUINILIQDK-UHFFFAOYSA-N 50040427 CHEMBL3360586 Carbonic anhydrase 4 Homo sapiens 233 ChEMBL 10.1016/j.bmc.2014.10.041 10.7270/Q2697560 25468040 Ceruso, M; Antel, S; Vullo, D; Scozzafava, A; Supuran, CT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50040427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50040427&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 118724328 313067450 CHEMBL3360586 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50258853 NS(=O)(=O)c1ccc(CCNC(=O)CCCNC(=O)Nc2ccccc2)cc1 InChI=1S/C19H24N4O4S/c20-28(26,27)17-10-8-15(9-11-17)12-14-21-18(24)7-4-13-22-19(25)23-16-5-2-1-3-6-16/h1-3,5-6,8-11H,4,7,12-14H2,(H,21,24)(H2,20,26,27)(H2,22,23,25) WTYBGEXCVVUKCD-UHFFFAOYSA-N 50040426 CHEMBL3360587 Carbonic anhydrase 4 Homo sapiens 439 ChEMBL 10.1016/j.bmc.2014.10.041 10.7270/Q2697560 25468040 Ceruso, M; Antel, S; Vullo, D; Scozzafava, A; Supuran, CT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50040426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50040426&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 101879106 313067449 CHEMBL3360587 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50258854 NS(=O)(=O)c1ccc(CNC(=O)CCCNC(=O)NCc2ccccc2)cc1 InChI=1S/C19H24N4O4S/c20-28(26,27)17-10-8-16(9-11-17)13-22-18(24)7-4-12-21-19(25)23-14-15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-14H2,(H,22,24)(H2,20,26,27)(H2,21,23,25) JCCDIFAGFKPVRO-UHFFFAOYSA-N 50040425 CHEMBL3360588 Carbonic anhydrase 4 Homo sapiens 880 ChEMBL 10.1016/j.bmc.2014.10.041 10.7270/Q2697560 25468040 Ceruso, M; Antel, S; Vullo, D; Scozzafava, A; Supuran, CT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50040425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50040425&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 118724329 313067448 CHEMBL3360588 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50258855 NS(=O)(=O)c1ccc(CCNC(=O)CCCNC(=O)NCc2ccccc2)cc1 InChI=1S/C20H26N4O4S/c21-29(27,28)18-10-8-16(9-11-18)12-14-22-19(25)7-4-13-23-20(26)24-15-17-5-2-1-3-6-17/h1-3,5-6,8-11H,4,7,12-15H2,(H,22,25)(H2,21,27,28)(H2,23,24,26) FQRCKFLQNUDOSU-UHFFFAOYSA-N 50040430 CHEMBL3360589 Carbonic anhydrase 4 Homo sapiens 780 ChEMBL 10.1016/j.bmc.2014.10.041 10.7270/Q2697560 25468040 Ceruso, M; Antel, S; Vullo, D; Scozzafava, A; Supuran, CT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50040430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50040430&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 118724330 313067453 CHEMBL3360589 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50258856 NS(=O)(=O)c1ccc(CNC(=O)CCCNC(=O)NCCc2ccccc2)cc1 InChI=1S/C20H26N4O4S/c21-29(27,28)18-10-8-17(9-11-18)15-24-19(25)7-4-13-22-20(26)23-14-12-16-5-2-1-3-6-16/h1-3,5-6,8-11H,4,7,12-15H2,(H,24,25)(H2,21,27,28)(H2,22,23,26) FTNXMXKINNNZSA-UHFFFAOYSA-N 50040429 CHEMBL3360590 Carbonic anhydrase 4 Homo sapiens 398 ChEMBL 10.1016/j.bmc.2014.10.041 10.7270/Q2697560 25468040 Ceruso, M; Antel, S; Vullo, D; Scozzafava, A; Supuran, CT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50040429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50040429&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 118724331 313067452 CHEMBL3360590 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50258857 NS(=O)(=O)c1ccc(CCNC(=O)CCCNC(=O)Nc2ccc(cc2)[N+]([O-])=O)cc1 InChI=1S/C19H23N5O6S/c20-31(29,30)17-9-3-14(4-10-17)11-13-21-18(25)2-1-12-22-19(26)23-15-5-7-16(8-6-15)24(27)28/h3-10H,1-2,11-13H2,(H,21,25)(H2,20,29,30)(H2,22,23,26) GIXRHINNRGUEBQ-UHFFFAOYSA-N 50040428 CHEMBL3360591 Carbonic anhydrase 4 Homo sapiens 738 ChEMBL 10.1016/j.bmc.2014.10.041 10.7270/Q2697560 25468040 Ceruso, M; Antel, S; Vullo, D; Scozzafava, A; Supuran, CT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50040428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50040428&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 101879108 313067451 CHEMBL3360591 C02125 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50258858 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2014.10.041 10.7270/Q2697560 25468040 Ceruso, M; Antel, S; Vullo, D; Scozzafava, A; Supuran, CT TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50285634 OP(O)([O-])=O InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-1 NBIIXXVUZAFLBC-UHFFFAOYSA-M 50155534 CHEMBL1368::NaH2PO4::monosodium phosphate::phosphoric acid, monosodium salt::sodium dihydrogen phosphate::sodium dihydrogenphosphate::sodium phosphate monobasic anhydrous::sodium phosphate, monobasic Carbonic anhydrase 4 Homo sapiens 7570000 ChEMBL 10.1016/j.bmcl.2004.09.064 10.7270/Q2V40TPN 15501037 Rusconi, S; Innocenti, A; Vullo, D; Mastrolorenzo, A; Scozzafava, A; Supuran, CT Università degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50155534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50155534&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2HP 2NP1,4XIX,1GXU,4IND,8H78,3Q24,2X1M,2X1L,3CH3,5TDE,2DEM,1A55,3C46,3Q23,1A54,4XIW,2DDG,2H0N,2JC4,1IXI,2DP6,3Q22,4TUF,1JSC,2OBE,6QFB,1PR9,4C4W 1003 104042947 37585 CHEMBL1368 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50285637 [O-]C(=O)P([O-])([O-])=O InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3 ZJAOAACCNHFJAH-UHFFFAOYSA-K 50027536 (phosphonoformate)Trisodium phosphonoformate::Antiviral agent : Inhibitor of reverse transcriptase of Human T-cell lymphotropic, virus type III, useful in the treatment of HSV-1 infections::CHEMBL754::EHB-776::FOSCARNET SODIUM::Foscarnet::Foscavir::phosphonoformate trisodium salt::trisodium dioxidophosphinecarboxylate oxide::trisodium dioxidophosphinecarboxylate oxide with 6 molecules of water(foscarnet)::trisodium phosphonoformate Carbonic anhydrase 4 Homo sapiens 820000.0 ChEMBL 10.1016/j.bmcl.2004.09.064 10.7270/Q2V40TPN 15501037 Rusconi, S; Innocenti, A; Vullo, D; Mastrolorenzo, A; Scozzafava, A; Supuran, CT Università degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50027536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50027536&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3414 103937006 141644 CHEMBL754 C06456 ZINC24629762 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50285643 OP([O-])([O-])=O InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 NBIIXXVUZAFLBC-UHFFFAOYSA-L 50080995 CHEMBL1060::Dibasic sodium phosphate::Disodium phosphate::Na2HPO4::disodium acid orthophosphate::disodium hydrogen phosphate::disodium hydrogenphosphate::disodium monohydrogen phosphate Carbonic anhydrase 4 Homo sapiens 9800 ChEMBL 10.1016/j.bmcl.2004.09.064 10.7270/Q2V40TPN 15501037 Rusconi, S; Innocenti, A; Vullo, D; Mastrolorenzo, A; Scozzafava, A; Supuran, CT Università degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080995&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IPS 3681305 103981094 34683 CHEMBL1060 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50285644 NC(=O)OP([O-])([O-])=O InChI=1S/CH4NO5P/c2-1(3)7-8(4,5)6/h(H2,2,3)(H2,4,5,6)/p-2 FFQKYPRQEYGKAF-UHFFFAOYSA-L 50155535 CHEMBL186043::Carbamoyl phosphate; di sodium Carbonic anhydrase 4 Homo sapiens 9900.0 ChEMBL 10.1016/j.bmcl.2004.09.064 10.7270/Q2V40TPN 15501037 Rusconi, S; Innocenti, A; Vullo, D; Mastrolorenzo, A; Scozzafava, A; Supuran, CT Università degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50155535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50155535&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3423467 104042948 17672 CHEMBL186043 C02133 ZINC08383183 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50285655 OC([O-])=O InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1 BVKZGUZCCUSVTD-UHFFFAOYSA-M 26986 CHEMBL363707::HCO3-::SODIUM BICARBONATE::bicarbonate ion::hydrogen carbonate Carbonic anhydrase 4 Homo sapiens 6600000 ChEMBL 10.1016/j.bmcl.2004.09.064 10.7270/Q2V40TPN 15501037 Rusconi, S; Innocenti, A; Vullo, D; Mastrolorenzo, A; Scozzafava, A; Supuran, CT Università degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26986&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BCT 3E2W,3V83,7R30,2JF9,2ILM,6YW0,6YW1,4ZJY,4IXQ,4IXR,4IXZ,4URF,2HC9,7PHO,4V82,3RV4,5B5E,7ADY,3G8C,4YRW,1ZTJ,3Q6J,5LHK,6OAD,7ZB0,7RF1,1HCB,6ABU,6VCF,6W1O,6W1V,6W1T,6W1R,6W1P,6W1Q,3HCN,3HCO,4WAK,6KAC,6KAF,6KAD,7PIN,7PIW,7PI5,7PI0,6KLZ,3U7C,7EVQ,5MX2,5B66,5LBC,2PIJ,4YSW,4Z9V,4FBY,7JRD,4LHD,5DRK,7RP9,7RPC,7RPB,7RPA,7RPF,7RPE,7RPD,5N4I,6WQP,4C7Z,4C7Y,1F9B,8GVC,6I33,6I35,6AC1,3OW5,6KM2,7ZAZ,7EGL,1S5L,4YTY,4YTZ,2A8D,7N8O,5ZJW,5TG6,5TG7,5TG4,5TG5,5OUF,6LV1,6LV2,6LV4,6LV6,6LV8,4PJ0,1YQW,3GLR,6A7X,5BXI,4DKI,4RY9,5NTD,5NTH,4H83,4WHQ,4WHP,4WHO,7YQ2,7YQ7,7ZZ3,7ZZ5,7EQU,3V7P,1OAO,2IST,2AXT,4K0X,4K0W,7COU,2BGS,4YUU,7RCV,3OU9,1VRG,7WK7,6G55,7N88,5D4O,5D4P,5O3Q,5O3R,3WDR,5HBC,3H02,5CRY,6DUX,1LI0,4ELS,1ZML,5ZAS,7OUI,5LAT,5TIS,4US8,4US9,4USA,2J7Y,2J7X,7ADR,6KM0,6KM1,8EZ5,3SXM,3SXK,4RVY,4RVA,5KAF,5KAI,6N7F,7A24,7A23,4ZLA,1CAM,1CAH,6YP7,7KCT,8EQM,8F4J,8F4K,8F4H,8F4I,8F4F,8F4G,8F4D,8F4C,4XZ5,3VBI,3VBK,3VBM,3VBL,4EML,7D1P,7D1T,7D1U,7D1N,6SC3,7KBL,4KLR,7EDA,4LHC,3DTB,2QD2,4YBO,7Y7A,6DIK,7ZB1,6F89,2FDA,7PNK,6SC0,4I4Z,4I42,7ZYY,6KI1,5V2C,5DEI,7D2J,4CLL,5WS5,5WS6,5GTI,3AN1,6DHH,6DHO,6DHF,6DHG,6DHE,6DHP,1V67,3H8G,3H8F,4C80,3WAE,1DXK,2ESF,3AX7,3AX9,4Z7J,1ZSJ,1ZSK,6W1U,1CL1,7O9N,6MYP,6J40,3AM9,3AMZ,7Y5E,2D3I,2VVB,4ZI6,6SJ0,7AIZ,7PE4,6UJ6,6XR0,7VD5,5ZZN,7C5V,7C5X,1LGD,2E3T,4PBU,7NHO,4MV9,4MV3,1BVT,7CJI,7CJJ,3WU2,2E1Q,6J3Y,6J3Z,4Q2H,6WJ6,6IM0,5CXK,7RF8,7RF5,7RF4,7RF7,7RF6,7RF3,7RF2,1BIC,5E79,5E7C,4A1T,6AJU,4UB8,4UB6,4V62,8EPZ,1JF8,1QRL,1QRE,4DUR,5ADT,5ADR,5ADS,5ADQ,6SQX,3E3F,3E3I,3VM1,4QRO,5LBE,5LBF,5LBB,3JCU,5FBK,5FBH,6JLP,6JLU,6JLJ,6JLK,6JLL,6JLM,6JLN,6JLO,4X53,4TNJ,4TNK,4TNH,4TNI,5XNM,6AD4,6YVX,6YVZ,5GTH,4RFD,5NSM,5NSP,2I4C,2I4B,4EGS,4IT1,8F4E,4OYZ,2C1L,5H2F,1MZ4,3E2A,3KZI,5OX5,4IL6,7CZL,5XNL 769 57298696 28976 CHEMBL363707 DB01390 C00288 ZINC06827693 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50285658 [O-]C=O InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 BDAGIHXWWSANSR-UHFFFAOYSA-M 50155538 CHEMBL183491::Sodium; formate::sodium formate Carbonic anhydrase 4 Homo sapiens 1250000 ChEMBL 10.1016/j.bmcl.2004.09.064 10.7270/Q2V40TPN 15501037 Rusconi, S; Innocenti, A; Vullo, D; Mastrolorenzo, A; Scozzafava, A; Supuran, CT Università degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50155538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50155538&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 283 104042951 18245 CHEMBL183491 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50285659 [O-]C([O-])=O InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2 BVKZGUZCCUSVTD-UHFFFAOYSA-L 26987 CHEMBL180485::CO3(2-)::SODIUM CARBONATE::carbonate::carbonate ion Carbonic anhydrase 4 Homo sapiens 5700000 ChEMBL 10.1016/j.bmcl.2004.09.064 10.7270/Q2V40TPN 15501037 Rusconi, S; Innocenti, A; Vullo, D; Mastrolorenzo, A; Scozzafava, A; Supuran, CT Università degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26987&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CO3 1XVX,1GYT,3NXL,4C1K,2DXY,7RIE,7F6R,4W79,3MBU,4IXS,3CFL,3JZF,2PMS,2DWA,2DWJ,2DWI,2DWH,3UNI,3UNC,3UNA,7C19,7Q5I,2EHA,1B0L,2O7U,3VDF,2XMX,7XU8,6EEE,3IIZ,3IIX,1OVB,1OVT,1ALQ,4WWL,1CE2,1D4N,1BIY,8EZ4,3FGS,5LN5,2OWT,2H4I,1TFD,3U72,7EV0,4H0W,4G77,1B1X,7SRV,1TZ8,3VE1,1L1E,1OXL,1USH,1N84,3BDJ,2ZMB,1SUV,4GME,2ALU,2R9J,1KZI,4FOR,7QOS,3NCE,3C9Q,3ZLV,1NNT,3QYT,3CSI,1EH3,1VFD,4ZY1,4ZYQ,7D6O,3F9O,2HCA,2O1L,4K3N,5FPP,2QJE,5GKD,5NNM,1FCK,6U1K,8HXM,7LI0,7LI1,3O5F,3GLT,3NCB,1TPY,3HJO,3HJM,1SI0,1H76,3JRU,6CTC,5N6Y,3GQ7,1FQF,1FQE,3CRB,7K5K,7C0K,1B8L,3X2W,3X2V,1DSN,4ZX8,4ZX9,5JIW,5KOZ,2EWB,1B3E,5L6Q,1BLF,3E9X,6BQC,2NWJ,4JYE,4JYF,3AA0,6JBB,1CM5,1N5M,3LXV,3HK8,3HK9,3HK5,3HK7,3HKA,3HKR,4C5B,3T8W,1H43,1H45,1H44,4ZY0,4ZY2,1D3K,3IPN,1A8F,6NW9,4UEQ,4UE0,6W4Q,7FDW,1LCT,1LCF,4ELQ,4ELP,4ELR,2AYS,7BUG,4G2Z,2OEL,1DOT,4K1W,6EE2,3S9L,3S9N,6GUD,6GUR,4R76,4R7M,3M2Z,3TOD,1IBJ,3KQZ,8BIB,3O97,2NQX,1IOM,4DIG,7BFR,5E3K,4GRK,3RGY,3KJ7,4DXU,2XGF,6FEA,3TUS,3CI8,7W1D,2G93,3WT4,3TTR,5GH0,4FFL,3LOG,2NUV,1GV8,1GVC,1IEJ,4N6P,1SQY,2D5H,7RTM,3V7T,1N7W,1N7X,1N76,2VXH,2E9E,2P1S,3HEM,3PCD,2DP8,3UK4,7C6W,7C67,1OI8,1HSE,6CJ0,3VCN,3KMN,1LAM,1I6Q,1JNF,2GJM,3S9M,7C0S,5Z9O,4LF2,1GHI,1GHM,2YQU,3SDF,3TAJ,2R71,1KPH,1KPI,1KPG,2OJV,1J07,1J06,3SZJ,3V4S,2IPS,7YXC,1JQF,2DS9,2DSF,7C15,7C16,3MKV,1DTG,1HP1,4X2T,3UGW,1LFG,1LFI,3KQX,3D48,7EBY,4NED,5DYH,1QJM,3IB2,3IB0,3IB1,6OME,2E0S,3LQC,3KR4,3KR5,4P9G,3V5A,2DYX,7C0O,6J9Y,3HGI,1SDX,4IUW,7FHM,2EFB,1W80,4A0U,4FIM,3MJN,3MFL,4CUO,3S0M,1OD5,6RN5,2DVC,6WB6,2BJJ,1OQH,1OQG,2WA6,2WA7,2WA5,3GQ8,2A2S,2A2R,7EA4,2IKC,3IAZ,1VFE,2DOJ,2E1S,3U8Q,6IME,3K0V,2G8X,2DXR,6TN6,3USD,3NCC,6A1I,6A1E,6LAA,2WHP,2FA7,7ENU,1A8E,4G8H,2O51,4NJQ,4NJR,3MV4,1X8H,1X8G,1NKX,2O84,2O86,4IAK,4IAI,2DQV,3M5T,3M5S,4FJP,1N04,4A6V,5CBM,2B65,2D5F,7T3V,3GUI,3GUJ,3GUP,4B3E,3HA4,3K7J,5MMY,4GXR,4GXQ,1FWA,7ULD,6D02,6D03,6D04,6D05,2I48,5C2X,5DJL,2WU3,3ES6,6MBA,4R6T,4EJ5,2WHR,6FHC,2OCU,2PX1,7O1P,2Q8J,4Q9X,2GYV,2GYW 19660 57298697 28976 CHEMBL180485 DB06724 C00288 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50285664 [O-]P([O-])([O-])=O InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3 NBIIXXVUZAFLBC-UHFFFAOYSA-K 50155537 CHEMBL363100::Na3PO4::Trinatriumphosphat::phosphoric acid trisodium salt::sodium orthophosphate::sodium phosphate::sodium phosphate, tribasic::tertiaeres Natriumphosphat(V)::tertiary sodium phosphate::tribasic sodium orthophosphate::tribasic sodium phosphate Carbonic anhydrase 4 Homo sapiens 84.0 ChEMBL 10.1016/j.bmcl.2004.09.064 10.7270/Q2V40TPN 15501037 Rusconi, S; Innocenti, A; Vullo, D; Mastrolorenzo, A; Scozzafava, A; Supuran, CT Università degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50155537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50155537&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PO4 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1061 104042950 37583 CHEMBL363100 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50293560 [O-]C(=O)CC([O-])=O InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)/p-2 OFOBLEOULBTSOW-UHFFFAOYSA-L 50159797 CHEMBL359504::Sodium; Malonate::sodium malonate Carbonic anhydrase 4 Homo sapiens 2800 ChEMBL 10.1016/j.bmcl.2004.11.057 10.7270/Q2TH8M6D 15664815 Innocenti, A; Vullo, D; Scozzafava, A; Casey, JR; Supuran, C Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50159797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50159797&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search MLI 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9084 104046199 15792 CHEMBL359504 DB02201 C00383 ZINC00895212 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50293562 OC([O-])=O InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1 BVKZGUZCCUSVTD-UHFFFAOYSA-M 26986 CHEMBL363707::HCO3-::SODIUM BICARBONATE::bicarbonate ion::hydrogen carbonate Carbonic anhydrase 4 Homo sapiens 6600000 ChEMBL 10.1016/j.bmcl.2004.11.057 10.7270/Q2TH8M6D 15664815 Innocenti, A; Vullo, D; Scozzafava, A; Casey, JR; Supuran, C Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26986&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BCT 3E2W,3V83,7R30,2JF9,2ILM,6YW0,6YW1,4ZJY,4IXQ,4IXR,4IXZ,4URF,2HC9,7PHO,4V82,3RV4,5B5E,7ADY,3G8C,4YRW,1ZTJ,3Q6J,5LHK,6OAD,7ZB0,7RF1,1HCB,6ABU,6VCF,6W1O,6W1V,6W1T,6W1R,6W1P,6W1Q,3HCN,3HCO,4WAK,6KAC,6KAF,6KAD,7PIN,7PIW,7PI5,7PI0,6KLZ,3U7C,7EVQ,5MX2,5B66,5LBC,2PIJ,4YSW,4Z9V,4FBY,7JRD,4LHD,5DRK,7RP9,7RPC,7RPB,7RPA,7RPF,7RPE,7RPD,5N4I,6WQP,4C7Z,4C7Y,1F9B,8GVC,6I33,6I35,6AC1,3OW5,6KM2,7ZAZ,7EGL,1S5L,4YTY,4YTZ,2A8D,7N8O,5ZJW,5TG6,5TG7,5TG4,5TG5,5OUF,6LV1,6LV2,6LV4,6LV6,6LV8,4PJ0,1YQW,3GLR,6A7X,5BXI,4DKI,4RY9,5NTD,5NTH,4H83,4WHQ,4WHP,4WHO,7YQ2,7YQ7,7ZZ3,7ZZ5,7EQU,3V7P,1OAO,2IST,2AXT,4K0X,4K0W,7COU,2BGS,4YUU,7RCV,3OU9,1VRG,7WK7,6G55,7N88,5D4O,5D4P,5O3Q,5O3R,3WDR,5HBC,3H02,5CRY,6DUX,1LI0,4ELS,1ZML,5ZAS,7OUI,5LAT,5TIS,4US8,4US9,4USA,2J7Y,2J7X,7ADR,6KM0,6KM1,8EZ5,3SXM,3SXK,4RVY,4RVA,5KAF,5KAI,6N7F,7A24,7A23,4ZLA,1CAM,1CAH,6YP7,7KCT,8EQM,8F4J,8F4K,8F4H,8F4I,8F4F,8F4G,8F4D,8F4C,4XZ5,3VBI,3VBK,3VBM,3VBL,4EML,7D1P,7D1T,7D1U,7D1N,6SC3,7KBL,4KLR,7EDA,4LHC,3DTB,2QD2,4YBO,7Y7A,6DIK,7ZB1,6F89,2FDA,7PNK,6SC0,4I4Z,4I42,7ZYY,6KI1,5V2C,5DEI,7D2J,4CLL,5WS5,5WS6,5GTI,3AN1,6DHH,6DHO,6DHF,6DHG,6DHE,6DHP,1V67,3H8G,3H8F,4C80,3WAE,1DXK,2ESF,3AX7,3AX9,4Z7J,1ZSJ,1ZSK,6W1U,1CL1,7O9N,6MYP,6J40,3AM9,3AMZ,7Y5E,2D3I,2VVB,4ZI6,6SJ0,7AIZ,7PE4,6UJ6,6XR0,7VD5,5ZZN,7C5V,7C5X,1LGD,2E3T,4PBU,7NHO,4MV9,4MV3,1BVT,7CJI,7CJJ,3WU2,2E1Q,6J3Y,6J3Z,4Q2H,6WJ6,6IM0,5CXK,7RF8,7RF5,7RF4,7RF7,7RF6,7RF3,7RF2,1BIC,5E79,5E7C,4A1T,6AJU,4UB8,4UB6,4V62,8EPZ,1JF8,1QRL,1QRE,4DUR,5ADT,5ADR,5ADS,5ADQ,6SQX,3E3F,3E3I,3VM1,4QRO,5LBE,5LBF,5LBB,3JCU,5FBK,5FBH,6JLP,6JLU,6JLJ,6JLK,6JLL,6JLM,6JLN,6JLO,4X53,4TNJ,4TNK,4TNH,4TNI,5XNM,6AD4,6YVX,6YVZ,5GTH,4RFD,5NSM,5NSP,2I4C,2I4B,4EGS,4IT1,8F4E,4OYZ,2C1L,5H2F,1MZ4,3E2A,3KZI,5OX5,4IL6,7CZL,5XNL 769 57298696 28976 CHEMBL363707 DB01390 C00288 ZINC06827693 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50293566 CC(=O)C([O-])=O InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 LCTONWCANYUPML-UHFFFAOYSA-M 50159792 CHEMBL181886::Natriumpyruvat::Pyruvate::pyruvic acid, sodium salt::sodium 2-oxopropanoate::sodium pyruvate Carbonic anhydrase 4 Homo sapiens 14500 ChEMBL 10.1016/j.bmcl.2004.11.057 10.7270/Q2TH8M6D 15664815 Innocenti, A; Vullo, D; Scozzafava, A; Casey, JR; Supuran, C Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50159792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50159792&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 107735 104046194 15361 CHEMBL181886 C00022 ZINC01532517 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50293569 CC([O-])=O InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 QTBSBXVTEAMEQO-UHFFFAOYSA-M 50159793 CHEMBL1354::Natriumazetat::SODIUM ACETATE ANHYDROUS::acetic acid, sodium salt::anhydrous sodium acetate::sodium acetate Carbonic anhydrase 4 Homo sapiens 550000 ChEMBL 10.1016/j.bmcl.2004.11.057 10.7270/Q2TH8M6D 15664815 Innocenti, A; Vullo, D; Scozzafava, A; Casey, JR; Supuran, C Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50159793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50159793&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ACT 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175 104046195 18245 CHEMBL1354 ZINC05224164 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50293570 OC(CC([O-])=O)(CC([O-])=O)C([O-])=O InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 KRKNYBCHXYNGOX-UHFFFAOYSA-K 92494 Citrate::SODIUM CITRATE Carbonic anhydrase 4 Homo sapiens 99.0 ChEMBL 10.1016/j.bmcl.2004.11.057 10.7270/Q2TH8M6D 15664815 Innocenti, A; Vullo, D; Scozzafava, A; Casey, JR; Supuran, C Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92494&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search FLC 7SU0,4LCV,3GCM,3HOI,2Q7B,4BGG,2QY2,4IMA,1M27,3W6G,7RIG,7RIH,2D4V,4ARE,7VYT,7C89,4UI0,2WVK,2JHS,2FT3,6JYJ,1B0M,1B0K,2OYE,7Q1I,4NSI,4NSX,4UW8,2XMI,2XMH,3G8W,7U99,6SSQ,3FXM,3FXL,4LMV,2B5W,4UZY,2BO4,3EXL,7Q1F,3FIR,5NG9,6EPI,6EPH,3TNZ,7X6F,6ECK,3GBD,3GBE,4QO3,6ZNW,4NRM,1W7R,4ASQ,4ASR,6J06,3PEA,6ABX,4BKP,2VJE,4IYA,5U0H,3I5W,2H4V,5N6M,2PLX,3U7Y,5JG4,7MDL,7MD6,1C96,6EOC,6EOE,6EOP,6B4C,3IDZ,6PA8,5ILN,1S69,1S6A,5D55,7E2W,6VUN,4PFM,2WJH,3A4Y,5ZI9,6PZV,2HXW,7CFL,3N9T,1I7A,2BN7,4RUN,4FWE,7U34,5FMM,4C7R,6F4H,4YIN,2G4U,6D8X,4RAY,4RA9,3H6U,3QY2,4ZDL,4BJ4,4GWV,3LYQ,7S2H,5UI0,7P4P,7NWO,6NN7,4D2E,5JHX,7MCU,1XK4,3C2H,2EV6,4XBT,7Q1J,4X4W,5X9R,4A3W,3RY8,3A7N,6H0C,7LFD,3Q4U,3LLK,8DEZ,6WGH,4QVH,6MLT,6HSA,5HVF,5XZA,2YG2,4PA5,5FN8,5CFL,5CFM,4QAL,5VOP,6U0O,7TVJ,6SMF,4DKK,4IP7,4GAC,4H1U,7KIA,4BRR,5E12,2W04,4E6T,3CRV,6FZV,6FZW,5U2O,5TZ7,4RB0,6DZR,3KHQ,5OJH,5IYW,5IYQ,5IYP,5IYR,2XEW,4ZXP,2GON,4E9M,4N6W,5TQH,7PVI,4K0A,5FQ0,6L6J,5D3V,6GTQ,2QK9,5TDE,2OOY,4J32,4J30,2X8Y,5Y79,4JYG,4JYI,4JYH,5FDN,6YI4,2Y3U,2BL8,6J4D,2GUZ,4R9I,5WGL,6HRI,6HRJ,7DKP,1N5I,2VZY,3O4Q,2YD6,4QBV,4ZM9,6U18,3WDK,7XH0,5JHW,7KIE,4RX3,7RMP,5HB5,4V31,3NK4,3NK3,1T6N,3H95,3WI5,8G5C,3KK6,3AVP,3AVQ,4Y5X,6VM8,5B74,3HQ1,6IW6,2WRS,5Z7H,5Z72,4J96,3BLW,3BLV,5FRD,6KRX,6KRW,7EE6,3SOM,8SA9,7RXE,5TEQ,5TES,7SZA,7SZB,4JXR,4JXQ,4KFU,4KFT,4KFS,5XAT,4LMD,1HH8,5HTK,5LQM,7LKT,6Y3C,3GNE,2P6W,5VIG,5O2N,5O2Z,3T9Z,3AVO,6CVE,5UAE,2IY6,4KZW,5OW2,5X6Y,4LSY,6MRY,6MR5,4JF5,6W5O,4R88,4PPQ,4PPN,4PPF,4PPG,6SBM,3FKY,7Q32,3D8Y,3D8Z,6VLV,2GIF,5MKR,2J9T,1C5Z,1C5Y,1C5X,1C5R,1C5W,5MB1,6B0Z,3EUA,2YPG,6L0W,5YHP,6MDX,6MDW,6MDQ,6H5A,4YWN,3M1X,6FMV,7O7K,7JV7,4CZ8,6G7Q,6QAZ,6N6T,3ZE3,3NRB,3JQM,5HR5,6DWI,5A1S,3BE8,3EB9,5XAS,3ZH4,4LR2,6LIL,6LI0,2WYM,5ZX8,7XE2,7XE3,7XE1,5UMN,5F35,3MQW,2J8T,2J80,3HZN,7OW1,5Z9Z,7SIG,4X84,3QS3,6IXN,5H5B,3WBD,3TA6,4AC7,4JZZ,6ARY,6ARX,2Y6I,4IIS,5SVF,5WXU,7YXB,6TLP,3IEM,3IEL,3NSG,6U4J,6SIX,6GMG,6IBY,6IBZ,7AH8,3I71,6MPA,6MP7,6ALA,6V3O,5EKT,7C11,6JYG,7NTK,3LN9,6CKL,2HRT,5LTG,5LTP,2HHP,5OFJ,5D85,3S1W,5W38,2P4Q,4N3U,6FKO,4AIN,6P1J,8EQQ,3QN2,4XEE,7QPR,5JXX,6IY9,2OK8,3B4Y,2BP1,6HVH,6HVI,6HVJ,1YTA,5CYF,4C91,6SJJ,6IC0,4YOL,5OR3,4KYQ,4UAM,7D9Z,1PO3,1PO0,5ZZO,7X8K,5K24,4AUB,3UFH,5JNP,8E0Y,1R0E,1R0B,5AEA,7SNR,3VGB,3VGF,3VGG,3VGE,5BSX,5BSY,6OS7,7U9A,4XDE,3P1M,7EA2,7T83,3D6N,3D6Q,2BJK,6IBX,7DMW,4QC4,5FA2,6WM5,2BWU,2BWT,2BWW,3RF6,7KJH,3IEK,4TO8,7RKZ,5JPE,3RHF,3OEI,2P2W,6YYR,6YYN,6YYO,2XU5,4F6Z,3WC3,1ZB7,6CRK,5HG1,2VJF,4A1F,4OUM,6W9R,5DMK,5V6A,5V64,7DTN,7XBE,5BR7,7UBZ,2ZSE,2ZSF,2ZS7,3AQU,5IWQ,4EI5,5W1A,6Z3C,3L3Q,4YPY,4S1A,3IKB,6EG1,6P3C,4J42,6PY9,2B76,3AF1,7T9Q,5X0Z,4UXZ,3D7B,3D71,6K53,7TGN,5JZE,3CNV,6XK0,6QFB,2R40,4AFQ,4AFF,4AFK,4LDC,4JW1,5LYK,6WNI,5CBP,2Y50,4C02,3UTO,7QGC,4YF1,4TNV,6HXQ,6HXO,6HXL,6HXM,6HXJ,6HXK,6HXH,6HXI,2IWT,4UYO,3O2V,3O2W,1V9A,5D56,2BHB,3MCF,2BWY,7B1K,5ZQV,7S13,1P0Z,6QP8,4BLP,5ONL,5ONK,4IE7,8EQP,3IE1,3IE0,5CTM,5CTN,4BRB,5MFX,6SBL,3WH2,3F1S,2FUF,4TX8,2EKN,4G9S,2O66,3VGH,3VGD,6KUX,5IVP,5OAJ,7TMB,4YQ4,4YQ5,2WHD,2WHG,7P4Q,5AGA,5WJA,7M8W,7DTM,2JFV,5THZ,6WMV,3BFP,5FXZ,4QSZ,4QSH,4QSK,5IK8,5IK7,2BH3,2BHA,2BHC,2BHD,1O9C,1O9E,3EXJ,7UTF 31348 160844991 35810 C17263 ZINC00895081 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50293573 [O-]C=O InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 BDAGIHXWWSANSR-UHFFFAOYSA-M 50155538 CHEMBL183491::Sodium; formate::sodium formate Carbonic anhydrase 4 Homo sapiens 1250000 ChEMBL 10.1016/j.bmcl.2004.11.057 10.7270/Q2TH8M6D 15664815 Innocenti, A; Vullo, D; Scozzafava, A; Casey, JR; Supuran, C Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50155538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50155538&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 283 104042951 18245 CHEMBL183491 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50293577 [O-]C(=O)C([O-])=O InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 MUBZPKHOEPUJKR-UHFFFAOYSA-L 92964 CHEMBL182928::Oxalate Carbonic anhydrase 4 Homo sapiens 99.0 ChEMBL 10.1016/j.bmcl.2004.11.057 10.7270/Q2TH8M6D 15664815 Innocenti, A; Vullo, D; Scozzafava, A; Casey, JR; Supuran, C Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92964&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search OXL 3FLK,1T2D,1BKA,6V75,6V74,6V76,3MOF,4RJD,1PT8,8HMS,8HMQ,8HMU,1PYM,4L80,2X75,6WP5,6WP4,6WP6,7L21,6QKK,2IU7,3B8I,2DUA,2EB5,6KSH,3FRL,2HWG,7Z53,4GMU,6N2C,4LAD,1O4T,1RYO,7P4D,7P4C,4NNC,1GQ2,6VC1,7R6Y,4OKN,4MFD,7FRW,7FRV,7FRY,7FRX,7FRZ,4WIU,4FXF,3ZPG,5N4A,1AYL,4OEV,5EZB,1NVM,8HMR,7QZU,1A5U,7FS0,7FS1,1PZH,1PZF,1LCF,3HQO,3HQP,3HQ9,6FOG,1DO8,7FS8,7FS9,7FS3,7FS6,7FS7,7FS4,7FS5,7FSB,7FSC,7FSA,7FSD,5FH3,4IRE,4B9Y,4B9Z,6SBI,6VF5,6ECH,1A49,5D1L,5D1M,5D1K,5HI0,3DT4,3DT2,2RK7,6NUB,6NU5,6NU1,6WP3,4ROT,3BJT,3BJF,5WSA,5WSC,5WSB,5WS9,5WS8,3M0K,4DBH,7FS2,5SCA,5SCC,5SCE,5SCD,5SCG,5SCF,5SCI,5SCK,5SCJ,5SCL,5SC9,5SC8,5NPE,5NPD,5NPC,5NPB,1T5A,3CV2,1DWK,4G1N,1SOW,4JN6,8G2E,2OWS,6KKH,8HPK,4KCW,7M48,3U8G,3K4Z,2VJO,5SDT,5V9G,4KS0,3SRD,4GNQ,4GNM,1GZ3,5N2C,5V7G,6ITO,1B7Z,6B6U,5SCB,5SCH,4L9Z 71081 163340099 51703 CHEMBL182928 ZINC04528594 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50293579 [O-]C(=O)c1c(F)c(F)cc(F)c1F InChI=1S/C7H2F4O2/c8-2-1-3(9)6(11)4(5(2)10)7(12)13/h1H,(H,12,13)/p-1 KVLBXIOFJUWSJQ-UHFFFAOYSA-M 50159796 2,3,5,6-F4-Benzoate::CHEMBL368444::Sodium; 2,3,5,6-tetrafluoro-benzoate::sodium 2,3,5,6-tetrafluorobenzoate Carbonic anhydrase 4 Homo sapiens 74500.0 ChEMBL 10.1016/j.bmcl.2004.11.057 10.7270/Q2TH8M6D 15664815 Innocenti, A; Vullo, D; Scozzafava, A; Casey, JR; Supuran, C Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50159796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50159796&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5162977 104046198 CHEMBL368444 ZINC00226731 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50293590 OC(CC([O-])=O)C([O-])=O InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2 BJEPYKJPYRNKOW-UHFFFAOYSA-L 50159798 CHEMBL182856::Sodium; L-Malate Carbonic anhydrase 4 Homo sapiens 53700.0 ChEMBL 10.1016/j.bmcl.2004.11.057 10.7270/Q2TH8M6D 15664815 Innocenti, A; Vullo, D; Scozzafava, A; Casey, JR; Supuran, C Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50159798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50159798&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 160434 104046200 15595 CHEMBL182856 C00711 ZINC00895264 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50293594 CC(O)C([O-])=O InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1 JVTAAEKCZFNVCJ-UHFFFAOYSA-M 50159794 CHEMBL1357::SODIUM LACTATE::Sodium; 2-hydroxy-propionate Carbonic anhydrase 4 Homo sapiens 1530000 ChEMBL 10.1016/j.bmcl.2004.11.057 10.7270/Q2TH8M6D 15664815 Innocenti, A; Vullo, D; Scozzafava, A; Casey, JR; Supuran, C Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50159794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50159794&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 91435 104046196 75228 CHEMBL1357 DB09294 C02929 ZINC04658562 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50293595 [O-]C(=O)c1ccccc1 InChI=1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)/p-1 WPYMKLBDIGXBTP-UHFFFAOYSA-M 36181 SODIUM BENZOATE::benzoate::benzoic acid::benzoic acid-d5 Carbonic anhydrase 4 Homo sapiens 74700.0 ChEMBL 10.1016/j.bmcl.2004.11.057 10.7270/Q2TH8M6D 15664815 Innocenti, A; Vullo, D; Scozzafava, A; Casey, JR; Supuran, C Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36181&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 242 103147828 16150 C00539 ZINC00001011 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50302938 F[Nb--](F)(F)(F)(F)(F)F InChI=1S/7FH.Nb/h7*1H;/q;;;;;;;+5/p-7 XSSWPVQSUAABDY-UHFFFAOYSA-G 50164076 CHEMBL180968::[NbF7]2- Carbonic anhydrase 4 Homo sapiens 500000 ChEMBL 10.1016/j.bmcl.2005.01.082 10.7270/Q2CR5SWP 15780631 Innocenti, A; Antel, J; Wurl, M; Vullo, D; Firnges, MA; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164076&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4712722 104049979 CHEMBL180968 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50302943 F[Fe-3](F)(F)(F)(F)F InChI=1S/6FH.Fe/h6*1H;/q;;;;;;+3/p-6 CBPSZAVQPJBCPU-UHFFFAOYSA-H 50164078 CHEMBL367362::[FeF6](3-)::hexafluoridoferrate(3-)hexafluoridoferrate(III)::hexafluoroferrate(3-) Carbonic anhydrase 4 Homo sapiens 340000 ChEMBL 10.1016/j.bmcl.2005.01.082 10.7270/Q2CR5SWP 15780631 Innocenti, A; Antel, J; Wurl, M; Vullo, D; Firnges, MA; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164078&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 26288 104049981 30946 CHEMBL367362 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50302948 Cl[Pt--](Cl)(Cl)Cl InChI=1S/4ClH.Pt/h4*1H;/q;;;;+2/p-4 SVZRVTAEYVVVPM-UHFFFAOYSA-J 50164081 CHEMBL366920::[PtCl4](2-)::tetrachloridoplatinate(2-)tetrachloridoplatinate(II)::tetrachloroplatinate(2-) Carbonic anhydrase 4 Homo sapiens 27500000 ChEMBL 10.1016/j.bmcl.2005.01.082 10.7270/Q2CR5SWP 15780631 Innocenti, A; Antel, J; Wurl, M; Vullo, D; Firnges, MA; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164081&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PC4 6ZRW,2FYF,4HGA,8AUC 61441 104049984 30118 CHEMBL366920 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50302950 Cl[Pt--](Cl)(Cl)(Cl)(Cl)Cl InChI=1S/6ClH.Pt/h6*1H;/q;;;;;;+4/p-6 GBFHNZZOZWQQPA-UHFFFAOYSA-H 50164077 CHEMBL181256::[PtCl6](2-)::hexachloridoplatinate(2-)hexachloridoplatinate(IV)::hexachloroplatinate(2-) Carbonic anhydrase 4 Homo sapiens 17400000 ChEMBL 10.1016/j.bmcl.2005.01.082 10.7270/Q2CR5SWP 15780631 Innocenti, A; Antel, J; Wurl, M; Vullo, D; Firnges, MA; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164077&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 61857 104049980 30119 CHEMBL181256 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50302956 N#C[Ag-]C#N InChI=1S/CN.Ag.N/c1-2;;/q;-1; JKVLHEJLXHUVEN-UHFFFAOYSA-N 50164080 CHEMBL359634::[Ag(CN)2]- Carbonic anhydrase 4 Homo sapiens 97000000 ChEMBL 10.1016/j.bmcl.2005.01.082 10.7270/Q2CR5SWP 15780631 Innocenti, A; Antel, J; Wurl, M; Vullo, D; Firnges, MA; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164080&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 23278873 104049983 CHEMBL359634 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50302974 F[As-](F)(F)(F)(F)F InChI=1S/AsF6/c2-1(3,4,5,6)7/q-1 ZENAVJHBLNXNHN-UHFFFAOYSA-N 50164087 AsF6-::CHEMBL181880 Carbonic anhydrase 4 Homo sapiens 5500000 ChEMBL 10.1016/j.bmcl.2005.01.082 10.7270/Q2CR5SWP 15780631 Innocenti, A; Antel, J; Wurl, M; Vullo, D; Firnges, MA; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164087&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 23515 104049990 CHEMBL181880 C19055 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50302982 N#C[Au-]C#N InChI=1S/CN.Au.N/c1-2;;/q;-1; JWDOBRIJUSBDRO-UHFFFAOYSA-N 50164086 CHEMBL180870::[Au(CN)2]- Carbonic anhydrase 4 Homo sapiens 5360000.0 ChEMBL 10.1016/j.bmcl.2005.01.082 10.7270/Q2CR5SWP 15780631 Innocenti, A; Antel, J; Wurl, M; Vullo, D; Firnges, MA; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164086&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 446142 104049989 CHEMBL180870 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50302984 N#C[Pd--](C#N)(C#N)C#N InChI=1S/3CN.N.Pd/c3*1-2;;/q;;;;-2 RFHHYUKIMJXVOY-UHFFFAOYSA-N 50164088 CHEMBL362447::[Pd(CN)4]2- Carbonic anhydrase 4 Homo sapiens 1690000 ChEMBL 10.1016/j.bmcl.2005.01.082 10.7270/Q2CR5SWP 15780631 Innocenti, A; Antel, J; Wurl, M; Vullo, D; Firnges, MA; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164088&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12049713 104049991 CHEMBL362447 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50302987 F[Al-3](F)(F)(F)(F)F InChI=1S/Al.6FH/h;6*1H/q+3;;;;;;/p-6 SEGUCIUJQMRTGG-UHFFFAOYSA-H 50164079 (OC-6-11)-hexafluoroaluminate(3-)::AlF6(3-)::CHEMBL181624::[AlF6](3-)::hexafluoridoaluminate(3-)::hexafluoroaluminate(3-) Carbonic anhydrase 4 Homo sapiens 124000000 ChEMBL 10.1016/j.bmcl.2005.01.082 10.7270/Q2CR5SWP 15780631 Innocenti, A; Antel, J; Wurl, M; Vullo, D; Firnges, MA; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164079&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 16682992 104049982 39288 CHEMBL181624 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50302991 F[P-](F)(F)(F)(F)F InChI=1S/F6P/c1-7(2,3,4,5)6/q-1 LJQLCJWAZJINEB-UHFFFAOYSA-N 36130 CHEMBL181124::sodium hexafluorophosphate Carbonic anhydrase 4 Homo sapiens 19100000 ChEMBL 10.1016/j.bmcl.2005.01.082 10.7270/Q2CR5SWP 15780631 Innocenti, A; Antel, J; Wurl, M; Vullo, D; Firnges, MA; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36130&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 9886 103147777 CHEMBL181124 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50302994 N#C[Cu-]C#N InChI=1S/CN.Cu.N/c1-2;;/q;-1; OEGSMTSJOHAESD-UHFFFAOYSA-N 50164082 CHEMBL181104::[Cu(CN)2]- Carbonic anhydrase 4 Homo sapiens 9800 ChEMBL 10.1016/j.bmcl.2005.01.082 10.7270/Q2CR5SWP 15780631 Innocenti, A; Antel, J; Wurl, M; Vullo, D; Firnges, MA; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164082&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 60167587 104049985 CHEMBL181104 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50300236 CP(O)(O)=O InChI=1S/CH5O3P/c1-5(2,3)4/h1H3,(H2,2,3,4) YACKEPLHDIMKIO-UHFFFAOYSA-N 50131862 CHEMBL122938::methylphosphonic acid Carbonic anhydrase 4 Homo sapiens 310000 ChEMBL 10.1016/j.bmcl.2005.01.049 10.7270/Q2NC60PJ 15745821 Winum, JY; Innocenti, A; Gagnard, V; Montero, JL; Scozzafava, A; Vullo, D; Supuran, CT University of Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131862&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search GB 1CFJ,6G3L,5O37,6FOR,2WG0,2WG1,6FVP,5LQ8,5LQ1 13818 104022894 48108 CHEMBL122938 ZINC34718034 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50300242 OP(O)(=O)CP(O)(O)=O InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) MBKDYNNUVRNNRF-UHFFFAOYSA-N 50162816 CHEMBL180570::Medronic acid::Methylene diphsphonate::Phosphonomethyl-phosphonic acid::methylenediphosphonic acid Carbonic anhydrase 4 Homo sapiens 5340000 ChEMBL 10.1016/j.bmcl.2005.01.049 10.7270/Q2NC60PJ 15745821 Winum, JY; Innocenti, A; Gagnard, V; Montero, JL; Scozzafava, A; Vullo, D; Supuran, CT University of Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50162816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50162816&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search MDN 1HUZ,3HXY,5TLH,5YSP,7E4L,6S83 16124 104048930 43945 CHEMBL180570 DB09138 ZINC38140720 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50300255 OP(O)(=O)c1ccccc1 InChI=1S/C6H7O3P/c7-10(8,9)6-4-2-1-3-5-6/h1-5H,(H2,7,8,9) QLZHNIAADXEJJP-UHFFFAOYSA-N 50162814 CHEMBL179801::Phenyl-phosphonic acid Carbonic anhydrase 4 Homo sapiens 5400 ChEMBL 10.1016/j.bmcl.2005.01.049 10.7270/Q2NC60PJ 15745821 Winum, JY; Innocenti, A; Gagnard, V; Montero, JL; Scozzafava, A; Vullo, D; Supuran, CT University of Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50162814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50162814&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SV7 5K4M,4CXS,4CYS 15295 104048928 CHEMBL179801 ZINC01555311 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50300256 OC(=O)P(O)(O)=O InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6) ZJAOAACCNHFJAH-UHFFFAOYSA-N 50011181 (PFA)dihydroxyphosphinecarboxylic acid oxide::CHEMBL666::FOSCARNET::Forscarnet::Foscarnet (PFA)::Foscavir::Phosphono-formic acid(PFA)::Phosphonoformate::dihydroxyphosphinecarboxylic acid oxide::dihydroxyphosphinecarboxylic acid oxide(PFA)::phosphonoformic acid(PFA) Carbonic anhydrase 4 Homo sapiens 820000.0 ChEMBL 10.1016/j.bmcl.2005.01.049 10.7270/Q2NC60PJ 15745821 Winum, JY; Innocenti, A; Gagnard, V; Montero, JL; Scozzafava, A; Vullo, D; Supuran, CT University of Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50011181&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PPF 2IT4,5HP1,3T01,1EI6,3KD5,2RK8,4MV7,1NKI 3415 103923827 127780 CHEMBL666 DB00529 5497 C06456 ZINC24629762 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50300260 NC(=O)OP(O)(O)=O InChI=1S/CH4NO5P/c2-1(3)7-8(4,5)6/h(H2,2,3)(H2,4,5,6) FFQKYPRQEYGKAF-UHFFFAOYSA-N 50162819 CHEMBL369105::Carbamyl phosphate::aminocarbonyl dihydrogen phosphate::carbamic phosphoric monoanhydride::carbamoyl dihydrogen phosphate::carbamoyl phosphate::monocarbamoyl phosphate Carbonic anhydrase 4 Homo sapiens 9900 ChEMBL 10.1016/j.bmcl.2005.01.049 10.7270/Q2NC60PJ 15745821 Winum, JY; Innocenti, A; Gagnard, V; Montero, JL; Scozzafava, A; Vullo, D; Supuran, CT University of Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50162819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50162819&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CP 6JKS,6JKR,1ZA2,7VZN,1C9Y,5G1P,3VEO,7VZY,7VZQ,7VYO,7VX0,6YSP,2I6U,7NNV,7VYJ,2G7M,3R7F,8BPL,6YVB,3L02,3L05,3L04,3L06,2FG7,7VYP,3MJM,6HL7,1EP9,1FVO,4H31,3VF4,3VF2,2AIR,3VEZ,3VET,6JL4,3KZO,4JFR,4JHX,3VES,3KZM,4NF2 278 104048933 17672 CHEMBL369105 C02133 ZINC08383183 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50300263 CC(OP(O)(O)=O)C(N)C(O)=O InChI=1S/C4H10NO6P/c1-2(3(5)4(6)7)11-12(8,9)10/h2-3H,5H2,1H3,(H,6,7)(H2,8,9,10) USRGIUJOYOXOQJ-UHFFFAOYSA-N 50162817 2-Amino-3-phosphonooxy-butyric acid::CHEMBL369507 Carbonic anhydrase 4 Homo sapiens 3180000 ChEMBL 10.1016/j.bmcl.2005.01.049 10.7270/Q2NC60PJ 15745821 Winum, JY; Innocenti, A; Gagnard, V; Montero, JL; Scozzafava, A; Vullo, D; Supuran, CT University of Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50162817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50162817&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search D11 2ITK 1016 104048931 CHEMBL369507 ZINC01574933 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50349646 NC(=O)NO InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4) VSNHCAURESNICA-UHFFFAOYSA-N 50017811 CHEMBL467::HU::US10155732, Compound HU::hydroxyurea Carbonic anhydrase 4 Homo sapiens 113000 ChEMBL 10.1016/j.bmcl.2006.05.068 10.7270/Q2HX1C9J 16759856 Temperini, C; Innocenti, A; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017811&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search NHY 3UB9,2GEH 3657 103929067 48349 CHEMBL467 DB01005 6822 C07044 ZINC08034120 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50349647 ONC(=O)Nc1ccc(Cl)c(Cl)c1 InChI=1S/C7H6Cl2N2O2/c8-5-2-1-4(3-6(5)9)10-7(12)11-13/h1-3,13H,(H2,10,11,12) VKYZMAVGJARVPE-UHFFFAOYSA-N 50188774 1-(3,4-dichlorophenyl)-3-hydroxyurea::CHEMBL213348 Carbonic anhydrase 4 Homo sapiens 890 ChEMBL 10.1016/j.bmcl.2006.05.068 10.7270/Q2HX1C9J 16759856 Temperini, C; Innocenti, A; Scozzafava, A; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188774&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 97463 104072523 CHEMBL213348 ZINC04809416 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50408342 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.5b01228 10.7270/Q2QC0591 26347950 Rankin, GM; Vullo, D; Supuran, CT; Poulsen, SA Griffith University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50436123 Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1 InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H IQPNAANSBPBGFQ-UHFFFAOYSA-N 7459 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one::CHEMBL151::Luteolin (27)::Luteolin (4)::acs.jmedchem.1c00409_ST.600::cid_5280445::luteolin::med.21724, Compound 3 Carbonic anhydrase 4 Homo sapiens 293 ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7459&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search LU2 4HKN,4QYA,6YA5,4DGN,5AUU,6M8A,4DEW,3SZ1,7D3B,7EBV,5II2,5NDF,4QXV 5280445 11108250 15864 CHEMBL151 5215 C01514 ZINC18185774 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50437222 Oc1ccc(CCOc2ccc(CCOC(=O)\C=C\c3ccc(O)c(O)c3)cc2)cc1 InChI=1S/C25H24O6/c26-21-7-1-18(2-8-21)13-15-30-22-9-3-19(4-10-22)14-16-31-25(29)12-6-20-5-11-23(27)24(28)17-20/h1-12,17,26-28H,13-16H2/b12-6+ NMSYSZHLZBCYSN-WUXMJOGZSA-N 50131681 CHEMBL3628131 Carbonic anhydrase 4 Homo sapiens 24100 ChEMBL 10.1016/j.bmc.2015.10.014 10.7270/Q29W0HB2 26498394 Maresca, A; Akyuz, G; Osman, SM; AlOthman, Z; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131681&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 122193189 321903349 CHEMBL3628131 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50437223 Oc1cccc(CCOc2cccc(CCOC(=O)\C=C\c3ccc(O)c(O)c3)c2)c1 InChI=1S/C25H24O6/c26-21-5-1-3-18(15-21)11-13-30-22-6-2-4-19(16-22)12-14-31-25(29)10-8-20-7-9-23(27)24(28)17-20/h1-10,15-17,26-28H,11-14H2/b10-8+ NIXPUWCVVMXORF-CSKARUKUSA-N 50131682 CHEMBL3628132 Carbonic anhydrase 4 Homo sapiens 33200 ChEMBL 10.1016/j.bmc.2015.10.014 10.7270/Q29W0HB2 26498394 Maresca, A; Akyuz, G; Osman, SM; AlOthman, Z; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131682&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 122193190 321903350 CHEMBL3628132 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50437224 COc1cc(\C=C\C(=O)OCc2ccccc2)ccc1O InChI=1S/C17H16O4/c1-20-16-11-13(7-9-15(16)18)8-10-17(19)21-12-14-5-3-2-4-6-14/h2-11,18H,12H2,1H3/b10-8+ DZAPHTCUSDTZAT-CSKARUKUSA-N 50131683 Benzyl (E)-Ferulate::Benzyl Ferulate Carbonic anhydrase 4 Homo sapiens 39500 ChEMBL 10.1016/j.bmc.2015.10.014 10.7270/Q29W0HB2 26498394 Maresca, A; Akyuz, G; Osman, SM; AlOthman, Z; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131683&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7766335 321903351 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50437225 COc1cc(\C=C\C(=O)OCCc2ccc(O)cc2)ccc1O InChI=1S/C18H18O5/c1-22-17-12-14(4-8-16(17)20)5-9-18(21)23-11-10-13-2-6-15(19)7-3-13/h2-9,12,19-20H,10-11H2,1H3/b9-5+ JMSFLLZUCIXALN-WEVVVXLNSA-N 50259746 (4-Hydroxyphenyl)ethyl trans-ferulate::CHEMBL481245::p-Hydroxyphenethyl trans-ferulate (18)::p-hydroxyphenethyl trans-ferulate Carbonic anhydrase 4 Homo sapiens 44000 ChEMBL 10.1016/j.bmc.2015.10.014 10.7270/Q29W0HB2 26498394 Maresca, A; Akyuz, G; Osman, SM; AlOthman, Z; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50259746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50259746&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 637308 104109887 CHEMBL481245 ZINC14503833 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50437226 COc1cc(\C=C\C(=O)OCCc2cccc(O)c2)ccc1O InChI=1S/C18H18O5/c1-22-17-12-14(5-7-16(17)20)6-8-18(21)23-10-9-13-3-2-4-15(19)11-13/h2-8,11-12,19-20H,9-10H2,1H3/b8-6+ QBAURLSDGDQXQA-SOFGYWHQSA-N 50131678 CHEMBL3628210 Carbonic anhydrase 4 Homo sapiens 40500 ChEMBL 10.1016/j.bmc.2015.10.014 10.7270/Q29W0HB2 26498394 Maresca, A; Akyuz, G; Osman, SM; AlOthman, Z; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131678&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 122193251 321903346 CHEMBL3628210 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50437227 Oc1ccc(\C=C\C(=O)OCc2ccccc2)cc1 InChI=1S/C16H14O3/c17-15-9-6-13(7-10-15)8-11-16(18)19-12-14-4-2-1-3-5-14/h1-11,17H,12H2/b11-8+ RGZZCZQQPNJCPO-DHZHZOJOSA-N 50362850 CHEMBL1095574 Carbonic anhydrase 4 Homo sapiens 18700 ChEMBL 10.1016/j.bmc.2015.10.014 10.7270/Q29W0HB2 26498394 Maresca, A; Akyuz, G; Osman, SM; AlOthman, Z; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362850&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10083644 136966912 CHEMBL1095574 ZINC14504998 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50437228 Oc1ccc(CCOC(=O)\C=C\c2ccc(O)cc2)cc1 InChI=1S/C17H16O4/c18-15-6-1-13(2-7-15)5-10-17(20)21-12-11-14-3-8-16(19)9-4-14/h1-10,18-19H,11-12H2/b10-5+ ZCFLGZLKECDZFW-BJMVGYQFSA-N 50131679 CHEMBL3628211::p-Hydroxyphenylethyl p-coumarate (17) Carbonic anhydrase 4 Homo sapiens 9670 ChEMBL 10.1016/j.bmc.2015.10.014 10.7270/Q29W0HB2 26498394 Maresca, A; Akyuz, G; Osman, SM; AlOthman, Z; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131679&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 16119626 321903347 CHEMBL3628211 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50437229 Oc1ccc(\C=C\C(=O)OCCc2cccc(O)c2)cc1 InChI=1S/C17H16O4/c18-15-7-4-13(5-8-15)6-9-17(20)21-11-10-14-2-1-3-16(19)12-14/h1-9,12,18-19H,10-11H2/b9-6+ OXEXRXXOYLBVDO-RMKNXTFCSA-N 50131680 CHEMBL3628212 Carbonic anhydrase 4 Homo sapiens 12500 ChEMBL 10.1016/j.bmc.2015.10.014 10.7270/Q29W0HB2 26498394 Maresca, A; Akyuz, G; Osman, SM; AlOthman, Z; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131680&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 122193252 321903348 CHEMBL3628212 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432584 Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1 InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H RTIXKCRFFJGDFG-UHFFFAOYSA-N 7461 5,7-dihydroxy-2-phenyl-4H-chromen-4-one::5,7-dihydroxy-2-phenyl-chromen-4-one::5,7-dihydroxyflavone::CHEMBL117::chrysin::cid_5281607 Carbonic anhydrase 4 Homo sapiens 538 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7461&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57D 4DES,3EBO,7D38 5281607 11108252 75095 CHEMBL117 C10028 ZINC03872070 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432586 Oc1cc(O)c2c(c1)oc(-c1ccccc1)c(O)c2=O InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H VCCRNZQBSJXYJD-UHFFFAOYSA-N 50049391 3,5,7-Trihydroxyflavone::3,5,7-triOH-flavone::3,5,7-trihydroxy-2-phenyl-4H-benzopyran-4-one::3,5,7-trihydroxy-2-phenyl-4H-chromen-4-one::CHEMBL309490::Galangin::Galangin (15)::Galangin (Gal)::cid_5281616::norizalpinin Carbonic anhydrase 4 Homo sapiens 568 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049391&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search KMC 8A0O 5281616 103979745 5262 CHEMBL309490 410 C10044 ZINC00120273 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432591 Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H IYRMWMYZSQPJKC-UHFFFAOYSA-N 7462 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one::3,5,7-trihydroxy-2-(4-hydroxyphenyl)-chromen-4-one::CHEMBL150::Kaempferol (18)::Kaempferol (Kmp)::cid_5280863::kaempferol Carbonic anhydrase 4 Homo sapiens >10000 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7462&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search KMP 5AV2,4DET,5AUX,6M8B,5AV3,4REL,3QWH,1H1M,7VEJ,2C1Z 5280863 11108253 28499 CHEMBL150 DB01852 C05903 ZINC03869768 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432593 COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O InChI=1S/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3 IZQSVPBOUDKVDZ-UHFFFAOYSA-N 23409 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one::CHEMBL379064::Isorhamnetin::Isorhamnetin (17) Carbonic anhydrase 4 Homo sapiens 213 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23409&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IRH 7CBA,6M8C 5281654 50091673 6052 CHEMBL379064 C10084 ZINC00517261 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432600 Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2/t13-/m0/s1 FTVWIRXFELQLPI-ZDUSSCGKSA-N 23419 (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one::CHEMBL9352::Naringenin Carbonic anhydrase 4 Homo sapiens 80 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23419&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search NAR 4A87,2UXU,4DEU,7BUR,4D06,1CGK,2BRT,6MS8,1EYQ,7VF0,4EH3,6G8H,7VEZ,5WKS,5WKR,7YJ9,7YJ7 439246 50091683 17846 CHEMBL9352 DB03467 C00509 ZINC00156701 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432601 Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccc(O)c(O)c1 InChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2/t13-/m0/s1 SBHXYTNGIZCORC-ZDUSSCGKSA-N 50325671 (2S)-2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE::(S)-2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-chroman-4-one::(S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one::(S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-4-one::5,7,3',4'-tetrahydroxyflavanone::5,7,3',4'-tetrahydroxyflavon::CHEMBL8996::ERIODICTYOL::eriodicryol::eryodictiol::hsp90_170 Carbonic anhydrase 4 Homo sapiens 73 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50325671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50325671&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ERD 2NNL,7YJB 440735 117646992 28412 CHEMBL8996 C05631 ZINC00058117 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432602 COc1ccc(cc1O)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1 AIONOLUJZLIMTK-AWEZNQCLSA-N 23418 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one::Hesperetin::Hesperitin Carbonic anhydrase 4 Homo sapiens 102 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23418&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 6JP 7POU,5JDC 72281 50091682 28230 DB01094 C01709 ZINC00039092 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432604 OC1C(=O)C(Oc2cc(O)cc(O)c12)c1ccc(O)c(O)c1 InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,13,15-20H BYVWXQRJRYELNP-UHFFFAOYSA-N 50049400 (+/-) taxifolin::(+/-)-Dihydroquercetin::(+/-)-taxifolin::(2R,3R)-2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chroman-4-one::(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one::2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chroman-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one::3,5,7,3',4'-pentahydroxyflavanone::CHEMBL337309::NSC-2801 Carbonic anhydrase 4 Homo sapiens 9098 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049400&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 53708475 103979754 38747 CHEMBL337309 ZINC00105086 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432607 Oc1ccc(cc1)-c1coc2cc(O)ccc2c1=O InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H ZQSIJRDFPHDXIC-UHFFFAOYSA-N 23420 7,4′-Dihydroxy-isoflavone (3a)::7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one::CHEMBL8145::Daidzein::US8552057, 7 Carbonic anhydrase 4 Homo sapiens 719 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23420&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ZF1 7EBU 5281708 50091684 28197 CHEMBL8145 2828 C10208 ZINC18847034 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432608 COc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3 WUADCCWRTIWANL-UHFFFAOYSA-N 9461 5,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one::Biochanin A (2)::Biochanin A (BCA)::Biochanin A, 9::CHEMBL131921::cid_5280373 Carbonic anhydrase 4 Homo sapiens 7079 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=9461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=9461&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search QSO 2QYO,5JMM,4FJ2 5280373 46510178 17574 CHEMBL131921 2829 C00814 ZINC18847037 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432609 OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)ccc2c1occ(-c1ccc(O)cc1)c2=O InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1 HKEAFJYKMMKDOR-VPRICQMDSA-N 50129558 CHEBI:8633::Puerarin Carbonic anhydrase 4 Homo sapiens >10000 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129558&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5281807 321902887 C10524 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432630 OC[C@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-25,27-30H,6H2/t13-,15-,17+,18-,21+/m1/s1 DPFYPHSPTUZJJT-QSOFNFLRSA-N 50241354 2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one::3,3',4',5,7-pentahydroxyflavone-3-beta-O-glucoside::3-glucoside isoquercitrin::CHEMBL250450::Hyperin::Hyperoside::NSC-407304::Quercetin 3-O-beta-D-glucoside::Quercetin-3-O-beta-D-galactopyranoside::Quercetin-3-glucoside::cid_5280804::cid_5378597::hirsutrin::hydroside::isoquercetin::isoquercetrin::quercetin -3-O-beta-D-galactopyranoside::quercetin 3-O-beta-D-galactopyranoside::quercetin 3-O-beta-D-glucopyranoside::quercetin 3-O-galactoside::quercetin 3-O-glucopyranoside::quercetin 3-O-glucoside::quercetin-3-galactoside Carbonic anhydrase 4 Homo sapiens 76 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241354&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5280804 104098737 68352 CHEMBL250450 C03400 ZINC04096845 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432631 C[C@H]1O[C@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)c(O)c2)[C@@H](O)[C@@H](O)[C@@H]1O InChI=1S/C21H20O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-18,21-26,28-29H,1H3/t7-,15-,17+,18+,21-/m1/s1 OXGUCUVFOIWWQJ-JHPRLSDPSA-N 50129557 QUERCETIN-3-O-RHAMNOSIDE Carbonic anhydrase 4 Homo sapiens 67 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129557&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 15939939 321902886 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432632 OC[C@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C21H20O11/c22-7-13-15(26)17(28)18(29)21(31-13)32-20-16(27)14-11(25)5-10(24)6-12(14)30-19(20)8-1-3-9(23)4-2-8/h1-6,13,15,17-18,21-24,26-29H,7H2/t13-,15-,17+,18-,21+/m1/s1 VLAZVXDNDNYUKJ-QSOFNFLRSA-N 50241243 3,4',5,7-Tetrahydroxyflavone-3-glucoside::3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one::4H-1-Benzopyran-4-one, 3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-::5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl beta-D-glucopyranoside::Astragalin::CHEMBL233930::cid_5282102::kaempferol 3-O-glucoside Carbonic anhydrase 4 Homo sapiens 5591 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241243&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5282102 104098672 30200 CHEMBL233930 C03400 ZINC04102435 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432633 O[C@@H]1[C@@H](COC(=O)C=Cc2ccc(O)cc2)O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)cc2)[C@H](O)[C@H]1O InChI=1S/C30H26O13/c31-16-6-1-14(2-7-16)3-10-22(35)40-13-21-24(36)26(38)27(39)30(42-21)43-29-25(37)23-19(34)11-18(33)12-20(23)41-28(29)15-4-8-17(32)9-5-15/h1-12,21,24,26-27,30-33,36-39H,13H2/t21-,24-,26+,27-,30+/m1/s1 HZLHIOUWCDTOOF-FIZCXTQCSA-N 50241244 (E)-((2R,3S,4S,5R,6S)-6-(5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yloxy)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-yl)methyl 3-(4-hydroxyphenyl)acrylate::CHEMBL266564::CHEMBL499705::Tiliroside::kaempferol 3-O-(6'' ''-O-E-p-coumaroyl)-beta-D-glucopyranoside::kaempferol-3-beta-D-(6-O-trans-p-coumaroyl)glucopyranoside::trans-Tiliroside Carbonic anhydrase 4 Homo sapiens 5469 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241244&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5320686 104098673 CHEMBL266564CHEMBL499705 ZINC17654711 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432648 O[C@@H]1[C@@H](COC(=O)\C=C\c2ccc(O)cc2)O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@H](OC(=O)\C=C\c2ccc(O)cc2)[C@H]1O InChI=1S/C39H32O15/c40-23-9-1-20(2-10-23)5-15-30(45)50-19-29-33(47)35(49)38(53-31(46)16-6-21-3-11-24(41)12-4-21)39(52-29)54-37-34(48)32-27(44)17-26(43)18-28(32)51-36(37)22-7-13-25(42)14-8-22/h1-18,29,33,35,38-44,47,49H,19H2/b15-5+,16-6+/t29-,33-,35+,38-,39+/m1/s1 YXXQUJGFZPLXJV-AIBWQOBZSA-N 50129556 CHEMBL3628129 Carbonic anhydrase 4 Homo sapiens 344 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129556&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10439991 321902885 CHEMBL3628129 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432649 CC(=O)O[C@@H]1[C@@H](COC(=O)\C=C\c2ccc(O)cc2)O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@H](OC(=O)\C=C\c2ccc(O)cc2)[C@H]1OC(C)=O InChI=1S/C43H36O17/c1-22(44)55-39-33(21-54-34(51)17-7-24-3-11-27(46)12-4-24)58-43(42(41(39)56-23(2)45)59-35(52)18-8-25-5-13-28(47)14-6-25)60-40-37(53)36-31(50)19-30(49)20-32(36)57-38(40)26-9-15-29(48)16-10-26/h3-20,33,39,41-43,46-50H,21H2,1-2H3/b17-7+,18-8+/t33-,39-,41+,42-,43+/m1/s1 IFLHDGGEJKVLAF-FEMPFSAESA-N 50129414 CHEMBL3628130 Carbonic anhydrase 4 Homo sapiens 62 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129414&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10328097 104020997 CHEMBL3628130 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432650 OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1\C=C\c1ccc(O)c(O)c1 InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+/t23-/m1/s1 YMGFTDKNIWPMGF-UCPJVGPRSA-N 50414250 CHEMBL457077 Carbonic anhydrase 4 Homo sapiens 67 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50414250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50414250&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5281793 163363274 CHEMBL457077 C10492 ZINC04098737 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432651 OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c2O[C@@H]([C@@H](C(O)=O)c12)c1ccc(O)c(O)c1 InChI=1S/C27H22O12/c28-15-5-1-12(9-18(15)31)10-20(26(34)35)38-21(33)8-4-13-2-7-17(30)25-22(13)23(27(36)37)24(39-25)14-3-6-16(29)19(32)11-14/h1-9,11,20,23-24,28-32H,10H2,(H,34,35)(H,36,37)/b8-4+/t20-,23+,24-/m1/s1 UJZQBMQZMKFSRV-RGKBJLTCSA-N 50250808 CHEMBL518243::lithospermic acid Carbonic anhydrase 4 Homo sapiens 101 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50250808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50250808&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 6441498 104104290 CHEMBL518243 C08745 ZINC04097774 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432652 OC(OC(Cc1ccc(O)c(O)c1)C(O)=O)C1C(Oc2cc(O)cc(\C=C\C(=O)OC(Cc3ccc(O)c(O)c3)C(O)=O)c12)c1ccc(O)c(O)c1 InChI=1S/C36H32O16/c37-20-13-18(4-8-30(44)50-28(34(45)46)11-16-1-5-21(38)24(41)9-16)31-27(15-20)51-33(19-3-7-23(40)26(43)14-19)32(31)36(49)52-29(35(47)48)12-17-2-6-22(39)25(42)10-17/h1-10,13-15,28-29,32-33,36-43,49H,11-12H2,(H,45,46)(H,47,48)/b8-4+ YLSNESYAOIRZEA-XBXARRHUSA-N 50414251 SALVIANOLIC ACID B Carbonic anhydrase 4 Homo sapiens 66 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50414251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50414251&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 56677421 163363275 C01707 ZINC49615488 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50432653 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 25.00 C ChEMBL 10.1016/j.bmc.2015.10.018 10.7270/Q2862J84 26498393 Karioti, A; Ceruso, M; Carta, F; Bilia, AR; Supuran, CT Aristotle University of Thessaloniki http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50446731 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2008.12.056 10.7270/Q2D50MT8 19121582 Bertucci, A; Innocenti, A; Zoccola, D; Scozzafava, A; Allemand, D; Tambutte, S; Supuran, CT Centre Scientifique de Monaco http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50446734 NS(N)(=O)=O InChI=1S/H4N2O2S/c1-5(2,3)4/h(H4,1,2,3,4) NVBFHJWHLNUMCV-UHFFFAOYSA-N 26995 CHEMBL355001::H2NSO2NH2::sulfamamide::sulfamide::sulfamoylamine Carbonic anhydrase 4 Homo sapiens 70000 ChEMBL 10.1016/j.bmcl.2008.12.056 10.7270/Q2D50MT8 19121582 Bertucci, A; Innocenti, A; Zoccola, D; Scozzafava, A; Allemand, D; Tambutte, S; Supuran, CT Centre Scientifique de Monaco http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26995&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search FUS 6D2N 82267 57298705 48266 CHEMBL355001 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50446737 NS(O)(=O)=O InChI=1S/H3NO3S/c1-5(2,3)4/h(H3,1,2,3,4) IIACRCGMVDHOTQ-UHFFFAOYSA-N 26994 CHEMBL68253::H2NSO3H::sulfamic acid Carbonic anhydrase 4 Homo sapiens 90000 ChEMBL 10.1016/j.bmcl.2008.12.056 10.7270/Q2D50MT8 19121582 Bertucci, A; Innocenti, A; Zoccola, D; Scozzafava, A; Allemand, D; Tambutte, S; Supuran, CT Centre Scientifique de Monaco http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26994&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5987 57298704 48266 CHEMBL68253 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50446740 OB(O)c1ccccc1 InChI=1S/C6H7BO2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9H HXITXNWTGFUOAU-UHFFFAOYSA-N 26996 CHEMBL21485::PhB(OH)2::Phenyl-boronic acid::Phenylboronic acid, 22::benzeneboronic acid::phenylboranediol::phenylboronic acid Carbonic anhydrase 4 Homo sapiens 820000 ChEMBL 10.1016/j.bmcl.2008.12.056 10.7270/Q2D50MT8 19121582 Bertucci, A; Innocenti, A; Zoccola, D; Scozzafava, A; Allemand, D; Tambutte, S; Supuran, CT Centre Scientifique de Monaco http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26996&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PBC 6VIM,1JU3,6UQU,4OB0,2A32 66827 57298706 44923 CHEMBL21485 DB01795 C16200 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50446743 O[As](O)(=O)c1ccccc1 InChI=1S/C6H7AsO3/c8-7(9,10)6-4-2-1-3-5-6/h1-5H,(H2,8,9,10) LVKZSFMYNWRPJX-UHFFFAOYSA-N 26997 CHEMBL364571::PhAsO3H2::benzenarsonic acid::benzenearsonic acid::phenylarsonic acid Carbonic anhydrase 4 Homo sapiens 13900000 ChEMBL 10.1016/j.bmcl.2008.12.056 10.7270/Q2D50MT8 19121582 Bertucci, A; Innocenti, A; Zoccola, D; Scozzafava, A; Allemand, D; Tambutte, S; Supuran, CT Centre Scientifique de Monaco http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26997&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7365 57298707 29851 CHEMBL364571 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50506601 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.6b00492 10.7270/Q2HT2R80 27144971 Akocak, S; Alam, MR; Shabana, AM; Sanku, RK; Vullo, D; Thompson, H; Swenson, ER; Supuran, CT; Ilies, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50506602 NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccc(NC(=O)CCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)Nc3ccc(cc3)S(=O)(=O)Nc3nnc(s3)S(N)(=O)=O)cc2)s1 InChI=1S/C116H210N12O57S6/c117-188(133,134)115-125-123-113(186-115)127-190(137,138)107-5-1-105(2-6-107)121-111(131)11-9-109(129)119-13-15-141-17-19-143-21-23-145-25-27-147-29-31-149-33-35-151-37-39-153-41-43-155-45-47-157-49-51-159-53-55-161-57-59-163-61-63-165-65-67-167-69-71-169-73-75-171-77-79-173-81-83-175-85-87-177-89-91-179-93-95-181-97-99-183-101-103-185-104-102-184-100-98-182-96-94-180-92-90-178-88-86-176-84-82-174-80-78-172-76-74-170-72-70-168-68-66-166-64-62-164-60-58-162-56-54-160-52-50-158-48-46-156-44-42-154-40-38-152-36-34-150-32-30-148-28-26-146-24-22-144-20-18-142-16-14-120-110(130)10-12-112(132)122-106-3-7-108(8-4-106)191(139,140)128-114-124-126-116(187-114)189(118,135)136/h1-8H,9-104H2,(H,119,129)(H,120,130)(H,121,131)(H,122,132)(H,123,127)(H,124,128)(H2,117,133,134)(H2,118,135,136) VCKCICDHXYEUSB-UHFFFAOYSA-N 50185295 CHEMBL3822883 Carbonic anhydrase 4 Homo sapiens 4.4 ChEMBL 10.1021/acs.jmedchem.6b00492 10.7270/Q2HT2R80 27144971 Akocak, S; Alam, MR; Shabana, AM; Sanku, RK; Vullo, D; Thompson, H; Swenson, ER; Supuran, CT; Ilies, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50185295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50185295&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127049242 104069515 CHEMBL3822883 ZINC13685772 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50506603 NS(=O)(=O)c1nnc(NC(=O)CCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)Nc2nnc(s2)S(N)(=O)=O)s1 InChI=1S/C104H200N10O53S4/c105-170(119,120)103-113-111-101(168-103)109-99(117)3-1-97(115)107-5-7-123-9-11-125-13-15-127-17-19-129-21-23-131-25-27-133-29-31-135-33-35-137-37-39-139-41-43-141-45-47-143-49-51-145-53-55-147-57-59-149-61-63-151-65-67-153-69-71-155-73-75-157-77-79-159-81-83-161-85-87-163-89-91-165-93-95-167-96-94-166-92-90-164-88-86-162-84-82-160-80-78-158-76-74-156-72-70-154-68-66-152-64-62-150-60-58-148-56-54-146-52-50-144-48-46-142-44-42-140-40-38-138-36-34-136-32-30-134-28-26-132-24-22-130-20-18-128-16-14-126-12-10-124-8-6-108-98(116)2-4-100(118)110-102-112-114-104(169-102)171(106,121)122/h1-96H2,(H,107,115)(H,108,116)(H2,105,119,120)(H2,106,121,122)(H,109,111,117)(H,110,112,118) VHMSKGDWLANAQW-UHFFFAOYSA-N 50185297 CHEMBL3822655 Carbonic anhydrase 4 Homo sapiens 5.8 ChEMBL 10.1021/acs.jmedchem.6b00492 10.7270/Q2HT2R80 27144971 Akocak, S; Alam, MR; Shabana, AM; Sanku, RK; Vullo, D; Thompson, H; Swenson, ER; Supuran, CT; Ilies, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50185297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50185297&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127049248 104069517 CHEMBL3822655 ZINC13685806 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50506604 NS(=O)(=O)c1ccc(NC(=O)CCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C112H208N6O53S2/c113-172(123,124)107-5-1-105(2-6-107)117-111(121)11-9-109(119)115-13-15-127-17-19-129-21-23-131-25-27-133-29-31-135-33-35-137-37-39-139-41-43-141-45-47-143-49-51-145-53-55-147-57-59-149-61-63-151-65-67-153-69-71-155-73-75-157-77-79-159-81-83-161-85-87-163-89-91-165-93-95-167-97-99-169-101-103-171-104-102-170-100-98-168-96-94-166-92-90-164-88-86-162-84-82-160-80-78-158-76-74-156-72-70-154-68-66-152-64-62-150-60-58-148-56-54-146-52-50-144-48-46-142-44-42-140-40-38-138-36-34-136-32-30-134-28-26-132-24-22-130-20-18-128-16-14-116-110(120)10-12-112(122)118-106-3-7-108(8-4-106)173(114,125)126/h1-8H,9-104H2,(H,115,119)(H,116,120)(H,117,121)(H,118,122)(H2,113,123,124)(H2,114,125,126) WHJLVHLMLADCRM-UHFFFAOYSA-N 50185298 CHEMBL3823514 Carbonic anhydrase 4 Homo sapiens 9.5 ChEMBL 10.1021/acs.jmedchem.6b00492 10.7270/Q2HT2R80 27144971 Akocak, S; Alam, MR; Shabana, AM; Sanku, RK; Vullo, D; Thompson, H; Swenson, ER; Supuran, CT; Ilies, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50185298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50185298&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127050812 104069518 CHEMBL3823514 ZINC13685789 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50506605 NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccc(NC(=O)CCC(=O)NCCOCCOCCNC(=O)CCC(=O)Nc3ccc(cc3)S(=O)(=O)Nc3nnc(s3)S(N)(=O)=O)cc2)s1 InChI=1S/C30H38N12O14S6/c31-59(47,48)29-39-37-27(57-29)41-61(51,52)21-5-1-19(2-6-21)35-25(45)11-9-23(43)33-13-15-55-17-18-56-16-14-34-24(44)10-12-26(46)36-20-3-7-22(8-4-20)62(53,54)42-28-38-40-30(58-28)60(32,49)50/h1-8H,9-18H2,(H,33,43)(H,34,44)(H,35,45)(H,36,46)(H,37,41)(H,38,42)(H2,31,47,48)(H2,32,49,50) FNEDBWUYFNKTAB-UHFFFAOYSA-N 50185299 CHEMBL3823200 Carbonic anhydrase 4 Homo sapiens 6.4 ChEMBL 10.1021/acs.jmedchem.6b00492 10.7270/Q2HT2R80 27144971 Akocak, S; Alam, MR; Shabana, AM; Sanku, RK; Vullo, D; Thompson, H; Swenson, ER; Supuran, CT; Ilies, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50185299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50185299&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127051953 104069519 CHEMBL3823200 ZINC13685749 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50506606 NS(=O)(=O)c1nnc(NC(=O)CCC(=O)NCCOCCOCCNC(=O)CCC(=O)Nc2nnc(s2)S(N)(=O)=O)s1 InChI=1S/C18H28N10O10S4/c19-41(33,34)17-27-25-15(39-17)23-13(31)3-1-11(29)21-5-7-37-9-10-38-8-6-22-12(30)2-4-14(32)24-16-26-28-18(40-16)42(20,35)36/h1-10H2,(H,21,29)(H,22,30)(H2,19,33,34)(H2,20,35,36)(H,23,25,31)(H,24,26,32) PSWPNJDDMZNTMH-UHFFFAOYSA-N 50185300 CHEMBL3822486 Carbonic anhydrase 4 Homo sapiens 5.0 ChEMBL 10.1021/acs.jmedchem.6b00492 10.7270/Q2HT2R80 27144971 Akocak, S; Alam, MR; Shabana, AM; Sanku, RK; Vullo, D; Thompson, H; Swenson, ER; Supuran, CT; Ilies, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50185300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50185300&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127051120 104069520 CHEMBL3822486 ZINC13685812 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50506607 NS(=O)(=O)c1ccc(NC(=O)CCC(=O)NCCOCCOCCNC(=O)CCC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C26H36N6O10S2/c27-43(37,38)21-5-1-19(2-6-21)31-25(35)11-9-23(33)29-13-15-41-17-18-42-16-14-30-24(34)10-12-26(36)32-20-3-7-22(8-4-20)44(28,39)40/h1-8H,9-18H2,(H,29,33)(H,30,34)(H,31,35)(H,32,36)(H2,27,37,38)(H2,28,39,40) CJBCHBJIAGRVKO-UHFFFAOYSA-N 50185301 CHEMBL3824097 Carbonic anhydrase 4 Homo sapiens 7.8 ChEMBL 10.1021/acs.jmedchem.6b00492 10.7270/Q2HT2R80 27144971 Akocak, S; Alam, MR; Shabana, AM; Sanku, RK; Vullo, D; Thompson, H; Swenson, ER; Supuran, CT; Ilies, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50185301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50185301&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127051119 104069521 CHEMBL3824097 ZINC09761170 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50506608 NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccc(NC(=O)CCC(O)=O)cc2)s1 InChI=1S/C12H13N5O7S3/c13-26(21,22)12-16-15-11(25-12)17-27(23,24)8-3-1-7(2-4-8)14-9(18)5-6-10(19)20/h1-4H,5-6H2,(H,14,18)(H,15,17)(H,19,20)(H2,13,21,22) OCQNLRXYCLHTBY-UHFFFAOYSA-N 50185302 CHEMBL3823618 Carbonic anhydrase 4 Homo sapiens 5.5 ChEMBL 10.1021/acs.jmedchem.6b00492 10.7270/Q2HT2R80 27144971 Akocak, S; Alam, MR; Shabana, AM; Sanku, RK; Vullo, D; Thompson, H; Swenson, ER; Supuran, CT; Ilies, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50185302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50185302&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127050822 104069522 CHEMBL3823618 ZINC19522935 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50506609 NS(=O)(=O)c1nnc(NC(=O)CCC(O)=O)s1 InChI=1S/C6H8N4O5S2/c7-17(14,15)6-10-9-5(16-6)8-3(11)1-2-4(12)13/h1-2H2,(H,12,13)(H2,7,14,15)(H,8,9,11) VEHPJMWKEUDKJE-UHFFFAOYSA-N 50185303 CHEMBL88115 Carbonic anhydrase 4 Homo sapiens 6.7 ChEMBL 10.1021/acs.jmedchem.6b00492 10.7270/Q2HT2R80 27144971 Akocak, S; Alam, MR; Shabana, AM; Sanku, RK; Vullo, D; Thompson, H; Swenson, ER; Supuran, CT; Ilies, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50185303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50185303&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 133125 104069523 CHEMBL88115 ZINC13685730 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50506610 NS(=O)(=O)c1ccc(NC(=O)CCC(O)=O)cc1 InChI=1S/C10H12N2O5S/c11-18(16,17)8-3-1-7(2-4-8)12-9(13)5-6-10(14)15/h1-4H,5-6H2,(H,12,13)(H,14,15)(H2,11,16,17) RXXXPZYBZLDQKP-UHFFFAOYSA-N 50185304 Sulfasuccinamide Carbonic anhydrase 4 Homo sapiens 486 ChEMBL 10.1021/acs.jmedchem.6b00492 10.7270/Q2HT2R80 27144971 Akocak, S; Alam, MR; Shabana, AM; Sanku, RK; Vullo, D; Thompson, H; Swenson, ER; Supuran, CT; Ilies, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50185304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50185304&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 60582 104069524 ZINC13685799 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501341 COc1ccc(cc1)C1C2=C(CC(C)(C)CC2=O)N(C2=C1C(=O)CC(C)(C)C2)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C33H35N5O6S2/c1-32(2)14-22-27(24(39)16-32)26(18-8-12-21(44-5)13-9-18)28-23(15-33(3,4)17-25(28)40)38(22)20-10-6-19(7-11-20)29(41)35-30-36-37-31(45-30)46(34,42)43/h6-13,26H,14-17H2,1-5H3,(H2,34,42,43)(H,35,36,41) IPGJCTOGVVZWNB-UHFFFAOYSA-N 50180241 CHEMBL3813758 Carbonic anhydrase 4 Homo sapiens 283 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180241&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127053004 346549626 CHEMBL3813758 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501342 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2ccc(Br)cc2)C(=O)CC(C)(C)C1)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C32H32BrN5O5S2/c1-31(2)13-21-26(23(39)15-31)25(17-5-9-19(33)10-6-17)27-22(14-32(3,4)16-24(27)40)38(21)20-11-7-18(8-12-20)28(41)35-29-36-37-30(44-29)45(34,42)43/h5-12,25H,13-16H2,1-4H3,(H2,34,42,43)(H,35,36,41) GWXUFXULPMHRCK-UHFFFAOYSA-N 50180242 CHEMBL3814764 Carbonic anhydrase 4 Homo sapiens 436 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180242&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127052714 346549627 CHEMBL3814764 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501343 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2ccc(Cl)cc2)C(=O)CC(C)(C)C1)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C32H32ClN5O5S2/c1-31(2)13-21-26(23(39)15-31)25(17-5-9-19(33)10-6-17)27-22(14-32(3,4)16-24(27)40)38(21)20-11-7-18(8-12-20)28(41)35-29-36-37-30(44-29)45(34,42)43/h5-12,25H,13-16H2,1-4H3,(H2,34,42,43)(H,35,36,41) ZYJONYNPPDAAHR-UHFFFAOYSA-N 50180243 CHEMBL3815152 Carbonic anhydrase 4 Homo sapiens 340 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180243&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127052713 346549628 CHEMBL3815152 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501344 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2ccc(F)cc2)C(=O)CC(C)(C)C1)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C32H32FN5O5S2/c1-31(2)13-21-26(23(39)15-31)25(17-5-9-19(33)10-6-17)27-22(14-32(3,4)16-24(27)40)38(21)20-11-7-18(8-12-20)28(41)35-29-36-37-30(44-29)45(34,42)43/h5-12,25H,13-16H2,1-4H3,(H2,34,42,43)(H,35,36,41) LPKJHRKTAGXLDI-UHFFFAOYSA-N 50180244 CHEMBL3814117 Carbonic anhydrase 4 Homo sapiens 63 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180244&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127052712 346549629 CHEMBL3814117 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501345 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2ccc(cc2)C#N)C(=O)CC(C)(C)C1)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C33H32N6O5S2/c1-32(2)13-22-27(24(40)15-32)26(19-7-5-18(17-34)6-8-19)28-23(14-33(3,4)16-25(28)41)39(22)21-11-9-20(10-12-21)29(42)36-30-37-38-31(45-30)46(35,43)44/h5-12,26H,13-16H2,1-4H3,(H2,35,43,44)(H,36,37,42) DLCRPOAIHJGMJK-UHFFFAOYSA-N 50180245 CHEMBL3814808 Carbonic anhydrase 4 Homo sapiens 361 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180245&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127049310 346549630 CHEMBL3814808 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501346 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2cccc(c2)C#N)C(=O)CC(C)(C)C1)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C33H32N6O5S2/c1-32(2)13-22-27(24(40)15-32)26(20-7-5-6-18(12-20)17-34)28-23(14-33(3,4)16-25(28)41)39(22)21-10-8-19(9-11-21)29(42)36-30-37-38-31(45-30)46(35,43)44/h5-12,26H,13-16H2,1-4H3,(H2,35,43,44)(H,36,37,42) ZWYIKHUMFJYWPA-UHFFFAOYSA-N 50180246 CHEMBL3814309 Carbonic anhydrase 4 Homo sapiens 708 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180246&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127048997 346549631 CHEMBL3814309 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501347 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2ccccc2)C(=O)CC(C)(C)C1)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C32H33N5O5S2/c1-31(2)14-21-26(23(38)16-31)25(18-8-6-5-7-9-18)27-22(15-32(3,4)17-24(27)39)37(21)20-12-10-19(11-13-20)28(40)34-29-35-36-30(43-29)44(33,41)42/h5-13,25H,14-17H2,1-4H3,(H2,33,41,42)(H,34,35,40) ALIRWUVFVCMRGG-UHFFFAOYSA-N 50180247 CHEMBL3814242 Carbonic anhydrase 4 Homo sapiens 61 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180247&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127048996 346549632 CHEMBL3814242 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501348 Nc1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C9H9N5O3S2/c10-6-3-1-5(2-4-6)7(15)12-8-13-14-9(18-8)19(11,16)17/h1-4H,10H2,(H2,11,16,17)(H,12,13,15) HNFIGQWLNNIMIU-UHFFFAOYSA-N 50180248 CHEMBL3813924 Carbonic anhydrase 4 Homo sapiens 30 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180248&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127048995 346549633 CHEMBL3813924 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501349 NS(=O)(=O)c1nnc(NC(=O)c2ccc(cc2)[N+]([O-])=O)s1 InChI=1S/C9H7N5O5S2/c10-21(18,19)9-13-12-8(20-9)11-7(15)5-1-3-6(4-2-5)14(16)17/h1-4H,(H2,10,18,19)(H,11,12,15) XGAOILXUBFKZJF-UHFFFAOYSA-N 50180249 CHEMBL3814487 Carbonic anhydrase 4 Homo sapiens 30 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180249&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127048994 346549634 CHEMBL3814487 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501350 CSc1ccc(cc1)C1C2=C(CC(C)(C)CC2=O)N(C2=C1C(=O)CC(C)(C)C2)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C33H35N5O5S3/c1-32(2)14-22-27(24(39)16-32)26(18-8-12-21(44-5)13-9-18)28-23(15-33(3,4)17-25(28)40)38(22)20-10-6-19(7-11-20)29(41)35-30-36-37-31(45-30)46(34,42)43/h6-13,26H,14-17H2,1-5H3,(H2,34,42,43)(H,35,36,41) NZBAGRLISPMPGZ-UHFFFAOYSA-N 50180240 CHEMBL3814887 Carbonic anhydrase 4 Homo sapiens 378 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180240&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127051804 346549625 CHEMBL3814887 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50513140 COc1cc(O)c(\C=C/C(O)=O)cc1[C@@H](O)CC(C)C InChI=1S/C15H20O5/c1-9(2)6-13(17)11-7-10(4-5-15(18)19)12(16)8-14(11)20-3/h4-5,7-9,13,16-17H,6H2,1-3H3,(H,18,19)/b5-4-/t13-/m0/s1 KXEZMFMTEVLUPQ-ZFDPJTLLSA-N 50296250 (S,Z)-3-(2-hydroxy-5-(1-hydroxy-3-methylbutyl)-4-methoxyphenyl)acrylate::CHEMBL560175 Carbonic anhydrase 4 Homo sapiens 380 ChEMBL 10.1016/j.bmcl.2009.06.002 10.7270/Q23778S7 19527930 Parkkila, S; Innocenti, A; Kallio, H; Hilvo, M; Scozzafava, A; Supuran, CT University of Tampere and Tampere University Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50296250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50296250&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TE1 3F8E 45269009 104137781 CHEMBL560175 ZINC43069883 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50513154 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Carbonic anhydrase 4 Homo sapiens 4553 ChEMBL 10.1016/j.bmcl.2009.06.002 10.7270/Q23778S7 19527930 Parkkila, S; Innocenti, A; Kallio, H; Hilvo, M; Scozzafava, A; Supuran, CT University of Tampere and Tampere University Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501351 Cc1ccc(cc1)C1C2=C(CC(C)(C)CC2=O)N(C2=C1C(=O)CC(C)(C)C2)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C33H35N5O5S2/c1-18-6-8-19(9-7-18)26-27-22(14-32(2,3)16-24(27)39)38(23-15-33(4,5)17-25(40)28(23)26)21-12-10-20(11-13-21)29(41)35-30-36-37-31(44-30)45(34,42)43/h6-13,26H,14-17H2,1-5H3,(H2,34,42,43)(H,35,36,41) HBJDDBMBFNYDBP-UHFFFAOYSA-N 50180239 CHEMBL3814664 Carbonic anhydrase 4 Homo sapiens 520 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180239&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127051805 346549624 CHEMBL3814664 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501352 CCc1ccc(cc1)C1C2=C(CC(C)(C)CC2=O)N(C2=C1C(=O)CC(C)(C)C2)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C34H37N5O5S2/c1-6-19-7-9-20(10-8-19)27-28-23(15-33(2,3)17-25(28)40)39(24-16-34(4,5)18-26(41)29(24)27)22-13-11-21(12-14-22)30(42)36-31-37-38-32(45-31)46(35,43)44/h7-14,27H,6,15-18H2,1-5H3,(H2,35,43,44)(H,36,37,42) CMYDORPUSYVKIR-UHFFFAOYSA-N 50180238 CHEMBL3814802 Carbonic anhydrase 4 Homo sapiens 425 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180238&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127051806 346549623 CHEMBL3814802 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501353 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2ccc(cc2)-c2ccccc2)C(=O)CC(C)(C)C1)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C38H37N5O5S2/c1-37(2)18-27-32(29(44)20-37)31(24-12-10-23(11-13-24)22-8-6-5-7-9-22)33-28(19-38(3,4)21-30(33)45)43(27)26-16-14-25(15-17-26)34(46)40-35-41-42-36(49-35)50(39,47)48/h5-17,31H,18-21H2,1-4H3,(H2,39,47,48)(H,40,41,46) UMPVDPDTLVIXGX-UHFFFAOYSA-N 50180237 CHEMBL3814718 Carbonic anhydrase 4 Homo sapiens 467 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180237&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127052106 346549622 CHEMBL3814718 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501354 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2cc(Br)ccc2O)C(=O)CC(C)(C)C1)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C32H32BrN5O6S2/c1-31(2)12-20-26(23(40)14-31)25(19-11-17(33)7-10-22(19)39)27-21(13-32(3,4)15-24(27)41)38(20)18-8-5-16(6-9-18)28(42)35-29-36-37-30(45-29)46(34,43)44/h5-11,25,39H,12-15H2,1-4H3,(H2,34,43,44)(H,35,36,42) SNQWQJRPLHXQDB-UHFFFAOYSA-N 50180267 CHEMBL3814163 Carbonic anhydrase 4 Homo sapiens 404 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180267&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127050568 346549641 CHEMBL3814163 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501355 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2ccc(Cl)cc2Cl)C(=O)CC(C)(C)C1)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C32H31Cl2N5O5S2/c1-31(2)12-21-26(23(40)14-31)25(19-10-7-17(33)11-20(19)34)27-22(13-32(3,4)15-24(27)41)39(21)18-8-5-16(6-9-18)28(42)36-29-37-38-30(45-29)46(35,43)44/h5-11,25H,12-15H2,1-4H3,(H2,35,43,44)(H,36,37,42) FBDNCCJHCMPTIK-UHFFFAOYSA-N 50180266 CHEMBL3814942 Carbonic anhydrase 4 Homo sapiens 139 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180266&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127050569 346549640 CHEMBL3814942 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501356 NS(=O)(=O)c1nnc(NC(=O)c2ccc(cc2)N2C3=C(C(C4=C2CCCC4=O)c2ccc(Cl)cc2)C(=O)CCC3)s1 InChI=1S/C28H24ClN5O5S2/c29-17-11-7-15(8-12-17)23-24-19(3-1-5-21(24)35)34(20-4-2-6-22(36)25(20)23)18-13-9-16(10-14-18)26(37)31-27-32-33-28(40-27)41(30,38)39/h7-14,23H,1-6H2,(H2,30,38,39)(H,31,32,37) HFOPGRFCSQCMTO-UHFFFAOYSA-N 50180265 CHEMBL3814523 Carbonic anhydrase 4 Homo sapiens 132 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180265&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127050570 346549639 CHEMBL3814523 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501357 NS(=O)(=O)c1nnc(NC(=O)c2ccc(cc2)N2C3=C(C(C4=C2CCCC4=O)c2ccc(Br)cc2)C(=O)CCC3)s1 InChI=1S/C28H24BrN5O5S2/c29-17-11-7-15(8-12-17)23-24-19(3-1-5-21(24)35)34(20-4-2-6-22(36)25(20)23)18-13-9-16(10-14-18)26(37)31-27-32-33-28(40-27)41(30,38)39/h7-14,23H,1-6H2,(H2,30,38,39)(H,31,32,37) AXIHBIYBPWUMDF-UHFFFAOYSA-N 50180264 CHEMBL3814976 Carbonic anhydrase 4 Homo sapiens 426 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180264&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127050571 346549638 CHEMBL3814976 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501358 Cc1ccc(cc1)C1C2=C(CCCC2=O)N(C2=C1C(=O)CCC2)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C29H27N5O5S2/c1-16-8-10-17(11-9-16)24-25-20(4-2-6-22(25)35)34(21-5-3-7-23(36)26(21)24)19-14-12-18(13-15-19)27(37)31-28-32-33-29(40-28)41(30,38)39/h8-15,24H,2-7H2,1H3,(H2,30,38,39)(H,31,32,37) FZUSOUIIKCKUND-UHFFFAOYSA-N 50180263 CHEMBL3814420 Carbonic anhydrase 4 Homo sapiens 96 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180263&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127050900 346549637 CHEMBL3814420 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501359 CCc1ccc(cc1)C1C2=C(CCCC2=O)N(C2=C1C(=O)CCC2)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C30H29N5O5S2/c1-2-17-9-11-18(12-10-17)25-26-21(5-3-7-23(26)36)35(22-6-4-8-24(37)27(22)25)20-15-13-19(14-16-20)28(38)32-29-33-34-30(41-29)42(31,39)40/h9-16,25H,2-8H2,1H3,(H2,31,39,40)(H,32,33,38) RJOMGMBJSTUALU-UHFFFAOYSA-N 50180262 CHEMBL3815009 Carbonic anhydrase 4 Homo sapiens 359 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180262&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127049970 346549636 CHEMBL3815009 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501360 CSc1ccc(cc1)C1C2=C(CCCC2=O)N(C2=C1C(=O)CCC2)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C29H27N5O5S3/c1-40-19-14-10-16(11-15-19)24-25-20(4-2-6-22(25)35)34(21-5-3-7-23(36)26(21)24)18-12-8-17(9-13-18)27(37)31-28-32-33-29(41-28)42(30,38)39/h8-15,24H,2-7H2,1H3,(H2,30,38,39)(H,31,32,37) WUOFZTRBZLCFMM-UHFFFAOYSA-N 50180250 CHEMBL3814927 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180250&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127049971 346549635 CHEMBL3814927 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501361 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2ccc(cc2)C2C3=C(CC(C)(C)CC3=O)N(C3=C2C(=O)CC(C)(C)C3)c2ccc(cc2)C(=O)Nc2nnc(s2)S(N)(=O)=O)C(=O)CC(C)(C)C1)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C58H60N10O10S4/c1-55(2)21-35-45(39(69)25-55)43(46-36(22-56(3,4)26-40(46)70)67(35)33-17-13-31(14-18-33)49(73)61-51-63-65-53(79-51)81(59,75)76)29-9-11-30(12-10-29)44-47-37(23-57(5,6)27-41(47)71)68(38-24-58(7,8)28-42(72)48(38)44)34-19-15-32(16-20-34)50(74)62-52-64-66-54(80-52)82(60,77)78/h9-20,43-44H,21-28H2,1-8H3,(H2,59,75,76)(H2,60,77,78)(H,61,63,73)(H,62,64,74) QRSMJZYCEJCRJJ-UHFFFAOYSA-N 50180235 CHEMBL3814291 Carbonic anhydrase 4 Homo sapiens 400 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180235&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127048632 346549620 CHEMBL3814291 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501362 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2cccc(c2)C2C3=C(CC(C)(C)CC3=O)N(C3=C2C(=O)CC(C)(C)C3)c2ccc(cc2)C(=O)Nc2nnc(s2)S(N)(=O)=O)C(=O)CC(C)(C)C1)c1ccc(cc1)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C58H60N10O10S4/c1-55(2)21-35-45(39(69)25-55)43(46-36(22-56(3,4)26-40(46)70)67(35)33-16-12-29(13-17-33)49(73)61-51-63-65-53(79-51)81(59,75)76)31-10-9-11-32(20-31)44-47-37(23-57(5,6)27-41(47)71)68(38-24-58(7,8)28-42(72)48(38)44)34-18-14-30(15-19-34)50(74)62-52-64-66-54(80-52)82(60,77)78/h9-20,43-44H,21-28H2,1-8H3,(H2,59,75,76)(H2,60,77,78)(H,61,63,73)(H,62,64,74) NLRHBVZSXCEKMK-UHFFFAOYSA-N 50180236 CHEMBL3814449 Carbonic anhydrase 4 Homo sapiens 248 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180236&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127050230 346549621 CHEMBL3814449 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50501363 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2016.05.064 10.7270/Q2N29ZVD 27298005 Ulus, R; Aday, B; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50513167 Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37) HHZIURLSWUIHRB-UHFFFAOYSA-N 50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib Carbonic anhydrase 4 Homo sapiens 446 ChEMBL 10.1016/j.bmcl.2009.06.002 10.7270/Q23778S7 19527930 Parkkila, S; Innocenti, A; Kallio, H; Hilvo, M; Scozzafava, A; Supuran, CT University of Tampere and Tampere University Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50237710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50237710&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search NIL 5MO4,3CS9,3GP0 644241 104056419 52172 CHEMBL255863 DB04868 5697 ZINC06716957 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50513180 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2009.06.002 10.7270/Q23778S7 19527930 Parkkila, S; Innocenti, A; Kallio, H; Hilvo, M; Scozzafava, A; Supuran, CT University of Tampere and Tampere University Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50502557 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.6b00443 10.7270/Q2TF0084 27172398 Mujumdar, P; Teruya, K; Tonissen, KF; Vullo, D; Supuran, CT; Peat, TS; Poulsen, SA Griffith University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50502573 NS(=O)(=O)CCNC(=O)C(\Cc1ccc(O)c(Br)c1)=N\O InChI=1S/C11H14BrN3O5S/c12-8-5-7(1-2-10(8)16)6-9(15-18)11(17)14-3-4-21(13,19)20/h1-2,5,16,18H,3-4,6H2,(H,14,17)(H2,13,19,20)/b15-9+ LZIKVOPNIDEBQJ-OQLLNIDSSA-N 50092612 CHEMBL3586274 Carbonic anhydrase 4 Homo sapiens 75 ChEMBL 10.1021/acs.jmedchem.6b00443 10.7270/Q2TF0084 27172398 Mujumdar, P; Teruya, K; Tonissen, KF; Vullo, D; Supuran, CT; Peat, TS; Poulsen, SA Griffith University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092612&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search OE2 5G01,5G03,5A6H 21726402 318473284 CHEMBL3586274 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589046 FC(F)(F)C(=O)NCCNCCCNCCNC(=O)C(F)(F)F InChI=1S/C11H18F6N4O2/c12-10(13,14)8(22)20-6-4-18-2-1-3-19-5-7-21-9(23)11(15,16)17/h18-19H,1-7H2,(H,20,22)(H,21,23) OOCHSWKGVKRYIA-UHFFFAOYSA-N 50323746 CHEMBL1214249::N1,N3-bis(2-(2,2,2-trifluoroacetamido)ethyl)-propane-1,3-diaminium trifluoroacetate Carbonic anhydrase 4 Homo sapiens 108000 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323746&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46899573 117645067 CHEMBL1214249 ZINC58538247 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589059 CC(C)(C)OC(=O)N(CCCN(CCNC(=O)C(F)(F)F)C(=O)OC(C)(C)C)CCNC(=O)C(F)(F)F InChI=1S/C21H34F6N4O6/c1-18(2,3)36-16(34)30(12-8-28-14(32)20(22,23)24)10-7-11-31(17(35)37-19(4,5)6)13-9-29-15(33)21(25,26)27/h7-13H2,1-6H3,(H,28,32)(H,29,33) FQICKRLWFXXDPR-UHFFFAOYSA-N 50323747 CHEMBL1214320::Di-tert-butylpropane-1,3-diylbis(2-(2,2,2-trifluoroacetamido)-ethylcarbamate Carbonic anhydrase 4 Homo sapiens 309000 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323747&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12066941 117645068 CHEMBL1214320 ZINC58540867 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589076 FC(F)(F)C(=O)NCCNCCNCCNC(=O)C(F)(F)F InChI=1S/C10H16F6N4O2/c11-9(12,13)7(21)19-5-3-17-1-2-18-4-6-20-8(22)10(14,15)16/h17-18H,1-6H2,(H,19,21)(H,20,22) KZYWBHHMDVXULL-UHFFFAOYSA-N 50323748 CHEMBL1214321::N1,N2-(2-(2,2,2-Trifluoroacetamido)ethyl)ethane-1,2-diaminium Trifluoroacetate Carbonic anhydrase 4 Homo sapiens >500000 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323748&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 15938557 117645069 CHEMBL1214321 ZINC58650324 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589089 CC(C)(C)OC(=O)N(CCNC(=O)C(F)(F)F)CCN(CCNC(=O)C(F)(F)F)C(=O)OC(C)(C)C InChI=1S/C20H32F6N4O6/c1-17(2,3)35-15(33)29(9-7-27-13(31)19(21,22)23)11-12-30(16(34)36-18(4,5)6)10-8-28-14(32)20(24,25)26/h7-12H2,1-6H3,(H,27,31)(H,28,32) XGBCUCRRKXJGDK-UHFFFAOYSA-N 50323749 CHEMBL1214322::Di-tert-butylethane-1,2-diylbis(2-(2,2,2-trifluoroacetamido)ethylcarbamate Carbonic anhydrase 4 Homo sapiens >500000 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323749&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12066940 117645070 CHEMBL1214322 ZINC58538167 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589102 CC(=O)NCCNc1cccc2ccccc12 InChI=1S/C14H16N2O/c1-11(17)15-9-10-16-14-8-4-6-12-5-2-3-7-13(12)14/h2-8,16H,9-10H2,1H3,(H,15,17) HZYHRPXUOHTHQR-UHFFFAOYSA-N 50323750 2,2,2-Trifluoro-N-(2-(naphthalen-1-ylamino)-acetamide::CHEMBL1214323 Carbonic anhydrase 4 Homo sapiens 12300 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323750&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2900806 117645071 CHEMBL1214323 ZINC04706717 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589115 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589128 NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) GJQPMPFPNINLKP-UHFFFAOYSA-N 10883 4,5-dichlorobenzene-1,3-disulfonamide::CHEMBL17::Dichlorophenamide::Dichlorophenamide (DCP)::Dichlorophenamide, DCP::Sulfonamide, 4::US10172837, Dichlorphenamide::sulfonamide 4 Carbonic anhydrase 4 Homo sapiens 15000 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10883&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search I7A 2POU 3038 46511453 101085 CHEMBL17 DB01144 6807 C07459 ZINC00896918 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589141 NCCNCCNCCN InChI=1S/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2 VILCJCGEZXAXTO-UHFFFAOYSA-N 50323751 CHEMBL609::N,N'-BIS(2-AMINOETHYL)-1,2-ETHANEDIAMINE::N,N'-Bis-(2-amino-ethyl)-ethane-1,2-diamine::Syprine::TRIENTINE::triethylenetetramine Carbonic anhydrase 4 Homo sapiens 35000 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323751&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 104 1DJ6 5565 117645072 39501 CHEMBL609 DB06824 C07166 ZINC19364225 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589154 Oc1ccccc1 InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H ISWSIDIOOBJBQZ-UHFFFAOYSA-N 26187 α-CA inhibitor, 11::CHEMBL14060::US9688816, 2::phenol Carbonic anhydrase 4 Homo sapiens 9500 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26187&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IPH 2PZV,3NX8,1XDA,4OLA,1MPJ,1PN0,5HPU,7AT0,1XW7,3AIY,3NC0,5USS,1JHY,1JHX,1WAV,2OMB,2OMN,3ROV,1FOH,5KI6,4W5Q,4W5R,4W5T,4W5N,1Q4V,4W5O,5URU,5JS1,5JS2,3ZS2,1XU5,6IY8,1AIY,5UU4,5UU3,6MFN,6MFR,1LI2,3Q3O,7JP3,3V1G,3V19,3JSD,5AIY,6Q7S,4A71,5FRW,2OLD,3ZQR,6TYH,3KQ6,3P2X,4JMW,5KBE,2WS6,2WS7,2J9N,1ZNJ,6MDZ,5ILG,1V03,7WDG,7WDH,1RWE,3KMH,4Z4F,4Z4G,4Z4D,4Z4E,4Z4C,4Z4H,4Z4I,1QIY,5BQQ,4F3T,1ZEG,6CK2,5W3R,4AIY,7VQF,1FJW,3GKY,4P65,5NQ8,1W8P,3U3E,5EMS,4AJZ,5T7B,3F39,4H07,4I7L,1AI0,1AI7,4AKJ,2AIY,2VE7,5HRQ,3GUO,5UDP,5WEA,4HDS,5UQA,2AS3,3P33,1LPH,6Z44 996 56464624 15882 CHEMBL14060 DB03255 C00146 ZINC05133329 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589167 NCCCNCCCCNCCCN InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 PFNFFQXMRSDOHW-UHFFFAOYSA-N 79403 3-aminopropyl-[4-(3-aminopropylamino)butyl]amine;hydrochloride::CHEMBL23194::MLS002472980::N,N''-bis(3-aminopropyl)butane-1,4-diamine;hydrochloride::N,N''-bis(3-azanylpropyl)butane-1,4-diamine;hydrochloride::N,N'-bis(3-aminopropyl)butane-1,4-diamine::SMR001397086::Spermine::cid_5351186::spermidine 3HCl Carbonic anhydrase 4 Homo sapiens 10 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79403&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SPM 3KWA,7QI6,7QI4,1DNS,4FAU,2D47,6YWV,6YWS,6YWX,6YWY,6YWE,7P2E,4P5J,2B2B,7QIZ,7QIW,1YB9,7K00,1VRO,198D,6E1X,1EI4,8AKN,8G6X,2PL8,2PLB,7NQL,7NQH,7D5D,7D5E,7OP3,7OP1,1RFI,1RFF,4FB0,1Y8L,1Y84,2DCG,4E8T,4E8Q,4E8P,4E8M,4E8N,4E8K,7FJQ,355D,1TN1,1TN2,1RGT,1RGU,1RG1,1RG2,3OZ5,1WOE,2RF3,1Z7I,258D,6E8S,6GAW,1EVV,6RSK,6RSJ,6T3R,6T3K,4FAR,6XXL,326D,3P4J,4R4A,6HIW,6HIV,6HIY,1ICK,2GUN,5OB3,4FAQ,4FAW,1J8G,1I2Y,1FQ2,3VKG,6CHR,1DPL,7OAX,4R87,1XPQ,7XIG,7YWZ,7YWS,6VFN,3TZO,7NE4,7NE5,7NE7,3EUI,324D,7EDT,1S2R,428D,7O7Z,7O7Y,1Z5T,131D,206D,6GAZ,2GWA,1PWF,1N7A,1N7B,1XPF,5VJ9,5VJB,2O3Y,7OAW,1D10,1D12,1D15,8AM9,1EDR,1RH0,5DE9,1OFX,2WLK,2WLJ,3C6M,8FV0,3BJ8,1I1P,7VPL,6S7D,3B7P,3LP9,3QJ7,2TRA,6GB2,7YX7,7N72,4MJ8,8ANA,6YDP,8EIU,1I0T,4R0D,410D,248D,6YEC,6AF2,2F8W,1FUF,5XJZ,7VPK,6RSL,8FV1,8A3D,323D,1M69,1DCR,210D,6YDW,3KU9,6GDA,7OB1,4MI4,1D48,100D,7ZJZ,2B8J,5V1L,320D,211D,321D,1F6C,6RW5,6RW4,7N78,1XL6,7NSJ,7NSH,7NSI,6XT7,4HQI,6UEJ,2C12,4NFO,7L0Z 1103 252656062 15746 CHEMBL23194 DB00127 C00750 ZINC01532734 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589180 NCCCCNCCCN InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2 ATHGHQPFGPMSJY-UHFFFAOYSA-N 50009353 1,5,10-triazadecane::4-azaoctamethylenediamine::4-azaoctane-1,8-diamine::CHEMBL19612::N-(3-aminopropyl)butane-1,4-diamine::spermidine Carbonic anhydrase 4 Homo sapiens 112 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50009353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50009353&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SPD 7A6T,8AGU,8AGW,8AGX,8AGZ,7QI6,7QI4,6IKM,7N30,7N31,7ZW0,8B7Y,7QIZ,7QIW,7K00,8G61,8G60,8G6W,8G6X,8G6J,8E6N,2O07,4FBL,4OGE,4OGC,8AAF,5HL7,7N1P,6SGC,2HMP,6DY5,8A5I,7PZY,3A76,7UG7,3BXZ,2YGP,6XXJ,6XXK,6HIW,6HIV,6HIY,6HIZ,6BQ7,7R81,8A63,5FOI,1I2X,8G5Y,8G5Z,8A57,8HD6,8HD7,2PWP,6LPV,6LPW,3LSA,7XIH,7XIF,4WFA,4WFB,4WF9,7XD6,4C0Z,5J5B,7OTC,7CI1,5JVG,3TTN,7O7Z,7O7Y,8A0E,8A0F,4YBB,7A18,8A0G,2P1E,2P18,7XJM,4LRO,7JNH,6YQ4,8GLP,3C6K,293D,3ICE,1POT,1POY,1TYP,7QEP,7Q08,7Q0P,1BO4,2ELG,5J7L,8EIU,6YE8,4CXM,3WR7,5HKV,3GK7,6YXY,4QF8,4MHD,5JC9,3L1R,5J8A,5J88,5IT8,7Q0F,7Q0R,7NHN,7OYS,7OYU,7OYT,7OYW,7OYV,7OYY,7OYX,7OYZ,7O80,7O81,6I7V,6TNU,8I7N,7OBZ,5NRG,5XDO,6V1R,5J91,7A5G,7A0S,3CN8,7PT0,3LS3,6QMM,7A5K,5XNH,7N2U,7N2V,7N2C,4WCE,6TB3,7XD5,7XD7,2QBY 1102 103922406 16610 CHEMBL19612 DB03566 2390 C00315 ZINC01532612 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589193 NCCNCCCNCCN InChI=1S/C7H20N4/c8-2-6-10-4-1-5-11-7-3-9/h10-11H,1-9H2 UWMHHZFHBCYGCV-UHFFFAOYSA-N 50323738 CHEMBL1214193::N,N'-bis-(3-aminoethyl)-1,3-propanediamine Carbonic anhydrase 4 Homo sapiens 44000 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323738&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 78479 117645059 30348 CHEMBL1214193 ZINC19364631 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50588933 CN(C)CCN(C)CCN(C)CCN(C)C InChI=1S/C12H30N4/c1-13(2)7-9-15(5)11-12-16(6)10-8-14(3)4/h7-12H2,1-6H3 DWFKOMDBEKIATP-UHFFFAOYSA-N 50323739 CHEMBL1214194::N1,N1'-(ethane-1,2-diyl)bis(N1,N2,N2-trimethylethane-1,2-diamine) Carbonic anhydrase 4 Homo sapiens 53 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323739&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 76509 117645060 CHEMBL1214194 ZINC19365690 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50588946 NCCCCCCN InChI=1S/C6H16N2/c7-5-3-1-2-4-6-8/h1-8H2 NAQMVNRVTILPCV-UHFFFAOYSA-N 50323740 CHEMBL303004 Carbonic anhydrase 4 Homo sapiens 450 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323740&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 16D 4BG1,4BGK,4BGM,4BHF,4BHG,4BHI,1WOG,2QK9,4C5W,3NIP 16402 117645061 39618 CHEMBL303004 DB03260 ZINC01543408 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50588955 NCCCCCN InChI=1S/C5H14N2/c6-4-2-1-3-5-7/h1-7H2 VHRGRCVQAFMJIZ-UHFFFAOYSA-N 50323741 CHEMBL119296 Carbonic anhydrase 4 Homo sapiens 52 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323741&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search N2P 4NSL,4OFG,5GJP,2OO0,5H8J,3QJ5,1H3M,6YE7,8EEO,1GZL,8D88 273 117645062 18127 CHEMBL119296 DB03854 C01672 ZINC01529253 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50588968 NCCNCCN InChI=1S/C4H13N3/c5-1-3-7-4-2-6/h7H,1-6H2 RPNUMPOLZDHAAY-UHFFFAOYSA-N 50323742 CHEMBL303429::N*1*-(2-Amino-ethyl)-ethane-1,2-diamine::N1-(2-aminoethyl)ethane-1,2-diamine Carbonic anhydrase 4 Homo sapiens 116000 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323742&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 8111 117645063 30629 CHEMBL303429 ZINC19230152 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50588981 NCCNc1cccc2ccccc12 InChI=1S/C12H14N2/c13-8-9-14-12-7-3-5-10-4-1-2-6-11(10)12/h1-7,14H,8-9,13H2 NULAJYZBOLVQPQ-UHFFFAOYSA-N 50323743 CHEMBL1214195::N1-(naphthalen-1-yl)ethane-1,2-diamine Carbonic anhydrase 4 Homo sapiens 58 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323743&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 15107 117645064 53510 CHEMBL1214195 ZINC01700217 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50588994 NCCCNCCCCNCCCNC(=O)Cc1cccc2ccccc12 InChI=1S/C22H34N4O/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27) ZUINPPQIQARTKX-UHFFFAOYSA-N 50100320 2-Naphthalen-1-yl-1-(4-{[4-(2-piperidin-1-yl-ethylamino)-butylamino]-methyl}-piperidin-1-yl)-ethanone::CHEMBL25101::N-(3-(4-(3-aminopropylamino)butylamino)propyl)-2-(naphthalen-1-yl)acetamide::N-{3-[4-(3-Amino-propylamino)-butylamino]-propyl}-2-naphthalen-1-yl-acetamide Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100320&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search GYY 6DM1 129695 103997107 CHEMBL25101 C13674 ZINC04654875 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589007 FC(F)(F)C(=O)NCCCNCCCCNCCCNC(=O)C(F)(F)F InChI=1S/C14H24F6N4O2/c15-13(16,17)11(25)23-9-3-7-21-5-1-2-6-22-8-4-10-24-12(26)14(18,19)20/h21-22H,1-10H2,(H,23,25)(H,24,26) RYJYHDWBXOJJKP-UHFFFAOYSA-N 50323744 CHEMBL1214248::N1,N12-Bis(trifluoroacetyl)spermine Bis Trifluoroacetate Carbonic anhydrase 4 Homo sapiens 116 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323744&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 388776 117645065 CHEMBL1214248 ZINC05501424 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589020 CC(C)(C)OC(=O)N(CCCCN(CCCNC(=O)C(F)(F)F)C(=O)OC(C)(C)C)CCCNC(=O)C(F)(F)F InChI=1S/C24H40F6N4O6/c1-21(2,3)39-19(37)33(15-9-11-31-17(35)23(25,26)27)13-7-8-14-34(20(38)40-22(4,5)6)16-10-12-32-18(36)24(28,29)30/h7-16H2,1-6H3,(H,31,35)(H,32,36) HOCFWFDAYHFZPF-UHFFFAOYSA-N 50323745 CHEMBL1212954::N1,N12-Bis(trifluoroacetyl)-N4,N8-bis(t-butoxycarbonyl)spermine Carbonic anhydrase 4 Homo sapiens 104000 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323745&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 389641 117645066 CHEMBL1212954 ZINC05834453 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50589033 CC(C)(C)OC(=O)N(CCCN)CCCCN(CCCN)C(=O)OC(C)(C)C InChI=1S/C20H42N4O4/c1-19(2,3)27-17(25)23(15-9-11-21)13-7-8-14-24(16-10-12-22)18(26)28-20(4,5)6/h7-16,21-22H2,1-6H3 SXSUKFQJCFUOTC-UHFFFAOYSA-N 50184773 (3-amino-propyl)-{4-[(3-amino-propyl)-tert-butoxycarbonyl-amino]-butyl}-carbamic acid tert-butyl ester::CHEMBL209126::N4,N8-Bis(t-butoxycarbonyl)spermine Carbonic anhydrase 4 Homo sapiens 103000 ChEMBL 10.1021/jm1003667 10.7270/Q22N52FB 20590092 Carta, F; Temperini, C; Innocenti, A; Scozzafava, A; Kaila, K; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184773&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 389642 104069092 CHEMBL209126 ZINC05713956 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641592 NS(=O)(=O)c1ccc(cc1)C(=O)OCCCCO[N+]([O-])=O InChI=1S/C11H14N2O7S/c12-21(17,18)10-5-3-9(4-6-10)11(14)19-7-1-2-8-20-13(15)16/h3-6H,1-2,7-8H2,(H2,12,17,18) JUGWLMZZNPHMLT-UHFFFAOYSA-N 50344551 4-(Nitrooxy)butyl-4-(aminosulfonyl)benzoate::CHEMBL1778431 Carbonic anhydrase 4 Homo sapiens 44 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344551&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25131351 131347487 CHEMBL1778431 ZINC71340629 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641594 NS(=O)(=O)c1ccc(cc1)C(=O)OCc1ccc(CO[N+]([O-])=O)cc1 InChI=1S/C15H14N2O7S/c16-25(21,22)14-7-5-13(6-8-14)15(18)23-9-11-1-3-12(4-2-11)10-24-17(19)20/h1-8H,9-10H2,(H2,16,21,22) MCDXWABKFCECMP-UHFFFAOYSA-N 50344552 4-(nitrooxymethyl)benzyl-4-sulfamoylbenzoate::CHEMBL1778432 Carbonic anhydrase 4 Homo sapiens 345 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344552&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25131685 131347488 CHEMBL1778432 ZINC71341429 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641595 COc1cc(\C=C\C(=O)OCCCCO[N+]([O-])=O)ccc1OC(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C21H22N2O10S/c1-30-19-14-15(5-11-20(24)31-12-2-3-13-32-23(26)27)4-10-18(19)33-21(25)16-6-8-17(9-7-16)34(22,28)29/h4-11,14H,2-3,12-13H2,1H3,(H2,22,28,29)/b11-5+ WGWRQZCFJUOFIR-VZUCSPMQSA-N 50344553 2-methoxy-4-(3-(4-(nitrooxy)butoxy)-3-oxoprop-1-enyl)phenyl-4-sulfamoylbenzoate::CHEMBL1778433 Carbonic anhydrase 4 Homo sapiens 47 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344553&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 24816432 131347489 CHEMBL1778433 ZINC71340311 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641596 NS(=O)(=O)c1nnc(NS(=O)(=O)c2cccc(c2)C(=O)OCCCCO[N+]([O-])=O)s1 InChI=1S/C13H15N5O9S3/c14-29(22,23)13-16-15-12(28-13)17-30(24,25)10-5-3-4-9(8-10)11(19)26-6-1-2-7-27-18(20)21/h3-5,8H,1-2,6-7H2,(H,15,17)(H2,14,22,23) QCXYDHYYUCXOLH-UHFFFAOYSA-N 50344554 4-(nitrooxy)butyl 3-(N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)sulfamoyl)benzoate::4-(nitrooxy)butyl 3-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)sulfamoyl]benzoate::CHEMBL1738778 Carbonic anhydrase 4 Homo sapiens 154 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344554&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search C1H 3NI5 53245686 131347490 CHEMBL1738778 ZINC66166852 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641597 COc1cc(\C=C\C(=O)OCCCCO[N+]([O-])=O)ccc1OC(=O)c1cccc(c1)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C23H23N5O12S3/c1-37-19-13-15(8-10-20(29)38-11-2-3-12-39-28(31)32)7-9-18(19)40-21(30)16-5-4-6-17(14-16)43(35,36)27-22-25-26-23(41-22)42(24,33)34/h4-10,13-14H,2-3,11-12H2,1H3,(H,25,27)(H2,24,33,34)/b10-8+ JMUJIEXVYMRWPU-CSKARUKUSA-N 50344555 2-methoxy-4-(3-(4-(nitrooxy)butoxy)-3-oxoprop-1-enyl)phenyl 3-(N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)sulfamoyl)benzoate::CHEMBL1778434 Carbonic anhydrase 4 Homo sapiens 225 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344555&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 54584666 131347491 CHEMBL1778434 ZINC72133997 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641598 NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccc(cc2)C(=O)OCCCCO[N+]([O-])=O)s1 InChI=1S/C13H15N5O9S3/c14-29(22,23)13-16-15-12(28-13)17-30(24,25)10-5-3-9(4-6-10)11(19)26-7-1-2-8-27-18(20)21/h3-6H,1-2,7-8H2,(H,15,17)(H2,14,22,23) OCFUQFUKHCFTNG-UHFFFAOYSA-N 50344556 4-(nitrooxy)butyl 4-(N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)sulfamoyl)benzoate::CHEMBL1778435 Carbonic anhydrase 4 Homo sapiens 46 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344556&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 54582723 131347492 CHEMBL1778435 ZINC71331143 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641599 COc1cc(\C=C\C(=O)OCCCCO[N+]([O-])=O)ccc1OC(=O)c1ccc(cc1)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C23H23N5O12S3/c1-37-19-14-15(5-11-20(29)38-12-2-3-13-39-28(31)32)4-10-18(19)40-21(30)16-6-8-17(9-7-16)43(35,36)27-22-25-26-23(41-22)42(24,33)34/h4-11,14H,2-3,12-13H2,1H3,(H,25,27)(H2,24,33,34)/b11-5+ QDSGUMZSKDGHAJ-VZUCSPMQSA-N 50344557 2-methoxy-4-(3-(4-(nitrooxy)butoxy)-3-oxoprop-1-enyl)phenyl 4-(N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)sulfamoyl)benzoate::CHEMBL1778436 Carbonic anhydrase 4 Homo sapiens 38 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344557&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 54581736 131347493 CHEMBL1778436 ZINC72133998 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641600 COc1cc(\C=C\C(=O)OCCCCO[N+]([O-])=O)ccc1OC(=O)CCc1ccc(cc1)S(N)(=O)=O InChI=1S/C23H26N2O10S/c1-32-21-16-18(8-12-22(26)33-14-2-3-15-34-25(28)29)6-11-20(21)35-23(27)13-7-17-4-9-19(10-5-17)36(24,30)31/h4-6,8-12,16H,2-3,7,13-15H2,1H3,(H2,24,30,31)/b12-8+ USKFDRXEOZVGAS-XYOKQWHBSA-N 50344558 4-(nitrooxy)butyl 3-(3-methoxy-4-(3-(4-sulfamoylphenyl)propanoyloxy)phenyl)acrylate::CHEMBL1778437 Carbonic anhydrase 4 Homo sapiens 139 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344558&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 54584667 131347494 CHEMBL1778437 ZINC71332555 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641601 NS(=O)(=O)c1ccc(OCCCO[N+]([O-])=O)cc1 InChI=1S/C9H12N2O6S/c10-18(14,15)9-4-2-8(3-5-9)16-6-1-7-17-11(12)13/h2-5H,1,6-7H2,(H2,10,14,15) FXJVYPSCKJAICG-UHFFFAOYSA-N 50344559 3-(4-sulfamoylphenoxy)propyl nitrate::CHEMBL1777820 Carbonic anhydrase 4 Homo sapiens 148 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344559&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 54585508 131347495 CHEMBL1777820 ZINC71341368 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641602 NS(=O)(=O)c1ccc(OCCCCO[N+]([O-])=O)cc1 InChI=1S/C10H14N2O6S/c11-19(15,16)10-5-3-9(4-6-10)17-7-1-2-8-18-12(13)14/h3-6H,1-2,7-8H2,(H2,11,15,16) ODJCADAZZYXNED-UHFFFAOYSA-N 50344560 4-(4-sulfamoylphenoxy)butyl nitrate::CHEMBL1778438 Carbonic anhydrase 4 Homo sapiens 76 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344560&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 54580732 131347496 CHEMBL1778438 ZINC71341394 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641603 NS(=O)(=O)c1ccc(OCCCCCO[N+]([O-])=O)cc1 InChI=1S/C11H16N2O6S/c12-20(16,17)11-6-4-10(5-7-11)18-8-2-1-3-9-19-13(14)15/h4-7H,1-3,8-9H2,(H2,12,16,17) BSCGCFHOYAYWGF-UHFFFAOYSA-N 50344561 5-(4-sulfamoylphenoxy)pentyl nitrate::CHEMBL1778439 Carbonic anhydrase 4 Homo sapiens 89 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50344561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50344561&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 54582724 131347497 CHEMBL1778439 ZINC71333602 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641604 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641605 NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) GJQPMPFPNINLKP-UHFFFAOYSA-N 10883 4,5-dichlorobenzene-1,3-disulfonamide::CHEMBL17::Dichlorophenamide::Dichlorophenamide (DCP)::Dichlorophenamide, DCP::Sulfonamide, 4::US10172837, Dichlorphenamide::sulfonamide 4 Carbonic anhydrase 4 Homo sapiens 15000 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10883&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search I7A 2POU 3038 46511453 101085 CHEMBL17 DB01144 6807 C07459 ZINC00896918 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50641606 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 IAVUPMFITXYVAF-XPUUQOCRSA-N 10884 (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide::Dorzolamide (DRZ)::Dorzolamide (DZA) Carbonic anhydrase 4 Homo sapiens 8500 ChEMBL 10.1016/j.bmcl.2011.04.046 10.7270/Q2GT5NHQ 21549597 Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT U.O. Oculistica Az. USL 3 http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10884&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ETS 4M2W,4M2U,4K13,3FW3,6BC9,1CIL 5284549 46511454 4702 DB00869 6810 C06969 ZINC01530621 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50629775 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2011.02.015 10.7270/Q2QN672R 21377369 Cincinelli, A; Martellini, T; Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50652759 NS(=O)(=O)c1ccc(CNc2nc(Cl)nc(NCC(O)=O)n2)cc1 InChI=1S/C12H13ClN6O4S/c13-10-17-11(19-12(18-10)16-6-9(20)21)15-5-7-1-3-8(4-2-7)24(14,22)23/h1-4H,5-6H2,(H,20,21)(H2,14,22,23)(H2,15,16,17,18,19) HGULMEYATWWKDO-UHFFFAOYSA-N 50167327 CHEMBL191045::[4-Chloro-6-(4-sulfamoyl-benzylamino)-[1,3,5]triazin-2-ylamino]-acetic acid Carbonic anhydrase 4 Homo sapiens 89 ChEMBL 10.1016/j.bmc.2011.04.005 10.7270/Q2FF3SQ6 21515057 Carta, F; Garaj, V; Maresca, A; Wagner, J; Avvaru, BS; Robbins, AH; Scozzafava, A; McKenna, R; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167327&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44399571 104052594 CHEMBL191045 ZINC55669669 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50652760 NS(=O)(=O)c1ccc(CCNc2nc(Cl)nc(NCC(O)=O)n2)cc1 InChI=1S/C13H15ClN6O4S/c14-11-18-12(20-13(19-11)17-7-10(21)22)16-6-5-8-1-3-9(4-2-8)25(15,23)24/h1-4H,5-7H2,(H,21,22)(H2,15,23,24)(H2,16,17,18,19,20) YEHQXDOOSDRWKW-UHFFFAOYSA-N 50167355 CHEMBL189526::{4-Chloro-6-[2-(4-sulfamoyl-phenyl)-ethylamino]-[1,3,5]triazin-2-ylamino}-acetic acid Carbonic anhydrase 4 Homo sapiens 97 ChEMBL 10.1016/j.bmc.2011.04.005 10.7270/Q2FF3SQ6 21515057 Carta, F; Garaj, V; Maresca, A; Wagner, J; Avvaru, BS; Robbins, AH; Scozzafava, A; McKenna, R; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167355&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44399462 104052622 CHEMBL189526 ZINC55669663 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50652761 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2011.04.005 10.7270/Q2FF3SQ6 21515057 Carta, F; Garaj, V; Maresca, A; Wagner, J; Avvaru, BS; Robbins, AH; Scozzafava, A; McKenna, R; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50659554 CCN(CC)c1ccc2c(Oc3cc(ccc3C22N(C(=O)c3ccccc23)c2ccc(cc2)S(N)(=O)=O)N(CC)CC)c1 InChI=1S/C34H36N4O4S/c1-5-36(6-2)24-15-19-29-31(21-24)42-32-22-25(37(7-3)8-4)16-20-30(32)34(29)28-12-10-9-11-27(28)33(39)38(34)23-13-17-26(18-14-23)43(35,40)41/h9-22H,5-8H2,1-4H3,(H2,35,40,41) UDDMXLGFVDCGOV-UHFFFAOYSA-N 50352643 CHEMBL1822699 Carbonic anhydrase 4 Homo sapiens 7200 7.5 ChEMBL 10.1016/j.bmcl.2011.07.045 10.7270/Q2XP75B3 21821413 Rami, M; Innocenti, A; Montero, JL; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352643&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 53386724 136359329 CHEMBL1822699 ZINC72179758 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50659567 CCN(CC)c1ccc2c(Oc3cc(ccc3C22N(C(=O)c3ccccc23)c2cccc(c2)S(N)(=O)=O)N(CC)CC)c1 InChI=1S/C34H36N4O4S/c1-5-36(6-2)23-16-18-29-31(21-23)42-32-22-24(37(7-3)8-4)17-19-30(32)34(29)28-15-10-9-14-27(28)33(39)38(34)25-12-11-13-26(20-25)43(35,40)41/h9-22H,5-8H2,1-4H3,(H2,35,40,41) NJYTXODBJNKKHC-UHFFFAOYSA-N 50352644 CHEMBL1822700 Carbonic anhydrase 4 Homo sapiens 6740 7.5 ChEMBL 10.1016/j.bmcl.2011.07.045 10.7270/Q2XP75B3 21821413 Rami, M; Innocenti, A; Montero, JL; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352644&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 53386866 136359330 CHEMBL1822700 ZINC72179759 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50659580 CCN(CC)c1ccc2c(Oc3cc(ccc3C22N(Cc3ccc(cc3)S(N)(=O)=O)C(=O)c3ccccc23)N(CC)CC)c1 InChI=1S/C35H38N4O4S/c1-5-37(6-2)25-15-19-30-32(21-25)43-33-22-26(38(7-3)8-4)16-20-31(33)35(30)29-12-10-9-11-28(29)34(40)39(35)23-24-13-17-27(18-14-24)44(36,41)42/h9-22H,5-8,23H2,1-4H3,(H2,36,41,42) ASDLWBSDLJPGLD-UHFFFAOYSA-N 50352645 CHEMBL1822701 Carbonic anhydrase 4 Homo sapiens 7450 7.5 ChEMBL 10.1016/j.bmcl.2011.07.045 10.7270/Q2XP75B3 21821413 Rami, M; Innocenti, A; Montero, JL; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352645&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 53386867 136359331 CHEMBL1822701 ZINC72179765 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50659593 CCN(CC)c1ccc2c(Oc3cc(ccc3C22N(CCc3ccc(cc3)S(N)(=O)=O)C(=O)c3ccccc23)N(CC)CC)c1 InChI=1S/C36H40N4O4S/c1-5-38(6-2)26-15-19-31-33(23-26)44-34-24-27(39(7-3)8-4)16-20-32(34)36(31)30-12-10-9-11-29(30)35(41)40(36)22-21-25-13-17-28(18-14-25)45(37,42)43/h9-20,23-24H,5-8,21-22H2,1-4H3,(H2,37,42,43) AXVQXDKRGPCGGE-UHFFFAOYSA-N 50352646 CHEMBL1822702 Carbonic anhydrase 4 Homo sapiens 7500 7.5 ChEMBL 10.1016/j.bmcl.2011.07.045 10.7270/Q2XP75B3 21821413 Rami, M; Innocenti, A; Montero, JL; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352646&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 53386868 136359332 CHEMBL1822702 ZINC72178811 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50659606 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 7.5 ChEMBL 10.1016/j.bmcl.2011.07.045 10.7270/Q2XP75B3 21821413 Rami, M; Innocenti, A; Montero, JL; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50721917 O\N=c1\ccc2ccccc2o1 InChI=1S/C9H7NO2/c11-10-9-6-5-7-3-1-2-4-8(7)12-9/h1-6,11H/b10-9- QIRWWZNGZWYHHM-KTKRTIGZSA-N 50366035 CHEMBL1956579 Carbonic anhydrase 4 Homo sapiens 750 ChEMBL 10.1016/j.bmcl.2012.01.129 10.7270/Q2FJ2H78 22365761 Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366035&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 6537802 136970097 CHEMBL1956579 ZINC05045449 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50721930 Cc1cc(C)o\c(c1)=N\O InChI=1S/C7H9NO2/c1-5-3-6(2)10-7(4-5)8-9/h3-4,9H,1-2H3/b8-7+ RGIHLYZDGZKVDV-BQYQJAHWSA-N 50366036 CHEMBL1956578 Carbonic anhydrase 4 Homo sapiens 260 ChEMBL 10.1016/j.bmcl.2012.01.129 10.7270/Q2FJ2H78 22365761 Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366036&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57345662 136970098 CHEMBL1956578 ZINC73314096 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50721943 OC(=S)c1ccccc1 InChI=1S/C7H6OS/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9) UIJGNTRUPZPVNG-UHFFFAOYSA-N 50366037 CHEMBL1955873 Carbonic anhydrase 4 Homo sapiens 8100 ChEMBL 10.1016/j.bmcl.2012.01.129 10.7270/Q2FJ2H78 22365761 Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366037&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7414 136970099 CHEMBL1955873 ZINC05226314 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50721944 OC(=S)c1ccccc1 InChI=1S/C7H6OS/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9) UIJGNTRUPZPVNG-UHFFFAOYSA-N 50366037 CHEMBL1955873 Carbonic anhydrase 4 Homo sapiens 8100 ChEMBL 10.1016/j.bmcl.2012.01.129 10.7270/Q2FJ2H78 22365761 Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366037&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7414 136970099 CHEMBL1955873 ZINC05226314 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50721969 [O-][n+]1ccccc1S InChI=1S/C5H5NOS/c7-6-4-2-1-3-5(6)8/h1-4,8H FGVVTMRZYROCTH-UHFFFAOYSA-N 50366038 CHEMBL1356238 Carbonic anhydrase 4 Homo sapiens 6130 ChEMBL 10.1016/j.bmcl.2012.01.129 10.7270/Q2FJ2H78 22365761 Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366038&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1570 136970100 36584 CHEMBL1356238 ZINC01482158 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50721970 [O-][n+]1ccccc1S InChI=1S/C5H5NOS/c7-6-4-2-1-3-5(6)8/h1-4,8H FGVVTMRZYROCTH-UHFFFAOYSA-N 50366038 CHEMBL1356238 Carbonic anhydrase 4 Homo sapiens 6130 ChEMBL 10.1016/j.bmcl.2012.01.129 10.7270/Q2FJ2H78 22365761 Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366038&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1570 136970100 36584 CHEMBL1356238 ZINC01482158 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734597 NS(=O)(=O)c1ccc(CO)cc1 InChI=1S/C7H9NO3S/c8-12(10,11)7-3-1-6(5-9)2-4-7/h1-4,9H,5H2,(H2,8,10,11) UULCVOIRJRJPQS-UHFFFAOYSA-N 10876 4-(hydroxymethyl)benzene-1-sulfonamide::CHEMBL6919::JMC522226 Compound 20::JMC523116 Compound 20::aromatic/heteroaromatic sulfonamide 21 Carbonic anhydrase 4 Homo sapiens 560 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10876&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10081162 46511447 CHEMBL6919 ZINC13442503 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734600 NS(=O)(=O)c1nc2ccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)Nc3ccc4nc(sc4c3)S(N)(=O)=O)CC(O)=O)CC(O)=O)cc2s1 InChI=1S/C28H33N9O12S4/c29-52(46,47)27-33-18-3-1-16(9-20(18)50-27)31-22(38)11-36(14-25(42)43)7-5-35(13-24(40)41)6-8-37(15-26(44)45)12-23(39)32-17-2-4-19-21(10-17)51-28(34-19)53(30,48)49/h1-4,9-10H,5-8,11-15H2,(H,31,38)(H,32,39)(H,40,41)(H,42,43)(H,44,45)(H2,29,46,47)(H2,30,48,49) VTXPJLWYFJDDQR-UHFFFAOYSA-N 50097275 CHEMBL286586::{{2-[Carboxymethyl-(2-{carboxymethyl-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 6 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097275&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10865717 103994607 CHEMBL286586 ZINC95608798 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734601 Nc1ccccc1S(N)(=O)=O InChI=1S/C6H8N2O2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) YAZSBRQTAHVVGE-UHFFFAOYSA-N 10855 2-aminobenzene-1-sulfonamide::CHEMBL6705::US10172837, 2-aminobenzenesulfonamide::aromatic/heteroaromatic sulfonamide 1::orthanilamide 17 Carbonic anhydrase 4 Homo sapiens 1310 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10855&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 72894 46511428 CHEMBL6705 ZINC00163348 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734604 NS(=O)(=O)c1ccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)Nc2ccc(cc2F)S(N)(=O)=O)CC(O)=O)CC(O)=O)c(F)c1 InChI=1S/C26H33F2N7O12S2/c27-18-9-16(48(29,44)45)1-3-20(18)31-22(36)11-34(14-25(40)41)7-5-33(13-24(38)39)6-8-35(15-26(42)43)12-23(37)32-21-4-2-17(10-19(21)28)49(30,46)47/h1-4,9-10H,5-8,11-15H2,(H,31,36)(H,32,37)(H,38,39)(H,40,41)(H,42,43)(H2,29,44,45)(H2,30,46,47) GYKVWKUDZTYCIL-UHFFFAOYSA-N 50097279 CHEMBL35338::{{2-[Carboxymethyl-(2-{carboxymethyl-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097279&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11028999 103994611 CHEMBL35338 ZINC95611950 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734605 NS(=O)(=O)c1cc(c(NC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)cc1Cl)S(N)(=O)=O InChI=1S/C20H29ClN6O13S2/c21-12-5-13(15(42(23,39)40)6-14(12)41(22,37)38)24-16(28)7-26(9-18(31)32)3-1-25(8-17(29)30)2-4-27(10-19(33)34)11-20(35)36/h5-6H,1-4,7-11H2,(H,24,28)(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H2,22,37,38)(H2,23,39,40) AXIMANCGDYFPRM-UHFFFAOYSA-N 50097278 (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(5-chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid::CHEMBL290348::{(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-[(5-chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 52 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097278&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3627258 103994610 CHEMBL290348 ZINC34717918 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734607 Nc1ccc(cc1Cl)S(N)(=O)=O InChI=1S/C6H7ClN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11) LFIOFZKZCDMGFG-UHFFFAOYSA-N 10863 4-Amino-3-chlorobenzenesulfonamide::4-amino-3-chlorobenzene-1-sulfonamide::CHEMBL7092::aromatic/heteroaromatic sulfonamide 8::halogenosulfanilamide deriv. 5c Carbonic anhydrase 4 Homo sapiens 320 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10863&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1502014 46511435 CHEMBL7092 ZINC01420707 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734608 Nc1cccc(c1)S(N)(=O)=O InChI=1S/C6H8N2O2S/c7-5-2-1-3-6(4-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) JPVKCHIPRSQDKL-UHFFFAOYSA-N 50079047 3-Amino-benzenesulfonamide::3-aminobenzenesulfonamide::CHEMBL6852 Carbonic anhydrase 4 Homo sapiens 2200 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079047&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7377 103971396 CHEMBL6852 ZINC03874012 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734610 NS(=O)(=O)c1ccc(CCNC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)NCCc2ccc(cc2)S(N)(=O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C30H43N7O12S2/c31-50(46,47)24-5-1-22(2-6-24)9-11-33-26(38)17-36(20-29(42)43)15-13-35(19-28(40)41)14-16-37(21-30(44)45)18-27(39)34-12-10-23-3-7-25(8-4-23)51(32,48)49/h1-8H,9-21H2,(H,33,38)(H,34,39)(H,40,41)(H,42,43)(H,44,45)(H2,31,46,47)(H2,32,48,49) GTBRQIOYGMBQQS-UHFFFAOYSA-N 50097277 ((2-{Carboxymethyl-[2-(carboxymethyl-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid::((2-{Carboxymethyl-[2-(carboxymethyl-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid;compound with Zn complex::CHEMBL1795062::CHEMBL286862::Zinc; ((2-{Carboxymethyl-[2-(carboxymethyl-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid Carbonic anhydrase 4 Homo sapiens 25 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097277&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11115351 103994609 CHEMBL286862CHEMBL1795062 ZINC95608819 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716041 Oc1c(O)c(Br)c(Cc2c(Br)c(O)c(O)c(Br)c2Br)cc1Br InChI=1S/C13H7Br5O4/c14-5-2-3(6(15)11(20)10(5)19)1-4-7(16)9(18)13(22)12(21)8(4)17/h2,19-22H,1H2 CVTMBOIHOUULML-UHFFFAOYSA-N 50363493 3,4,6-tribromo-5-(2,5-dibromo-3,4-dihydroxybenzyl)benzene-1,2-diol (3)::CHEMBL464987 Carbonic anhydrase 4 Homo sapiens 27480 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363493&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 21778117 136967555 CHEMBL464987 ZINC49850857 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716042 Oc1c(O)c(Br)c(Cc2c(Br)c(O)c(O)c(Br)c2Br)c(Br)c1Br InChI=1S/C13H6Br6O4/c14-4-2(6(16)10(20)12(22)8(4)18)1-3-5(15)9(19)13(23)11(21)7(3)17/h20-23H,1H2 AMKNSMNMEAMKDN-UHFFFAOYSA-N 50363494 5,5'-methylenebis(3,4,6-tribromo-benzene-1,2-diol) (4)::CHEMBL374829 Carbonic anhydrase 4 Homo sapiens 28040 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363494&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 21778115 136967556 CHEMBL374829 ZINC28707385 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716043 Oc1c(O)c(Br)c(C[C@H]2CCCCC2=O)c(Br)c1Br InChI=1S/C13H13Br3O3/c14-9-7(5-6-3-1-2-4-8(6)17)10(15)12(18)13(19)11(9)16/h6,18-19H,1-5H2/t6-/m1/s1 LLMBLIAKCCQZSI-ZCFIWIBFSA-N 50363495 CHEMBL490356 Carbonic anhydrase 4 Homo sapiens 1080 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363495&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10366827 136967557 CHEMBL490356 ZINC14769554 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716044 CC(=O)OCc1c(Br)c(Br)c(OC(C)=O)c(OC(C)=O)c1Br InChI=1S/C13H11Br3O6/c1-5(17)20-4-8-9(14)11(16)13(22-7(3)19)12(10(8)15)21-6(2)18/h4H2,1-3H3 JNSSHQBERKQWMC-UHFFFAOYSA-N 50363496 CHEMBL1946084 Carbonic anhydrase 4 Homo sapiens 102400 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363496&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57397836 136967558 CHEMBL1946084 ZINC73199015 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716045 COc1c(Br)c(Br)c(CC2CCCCC2=O)c(Br)c1OC InChI=1S/C15H17Br3O3/c1-20-14-12(17)9(11(16)13(18)15(14)21-2)7-8-5-3-4-6-10(8)19/h8H,3-7H2,1-2H3 SYDTZDJUBISFCH-UHFFFAOYSA-N 50363497 CHEMBL1946085 Carbonic anhydrase 4 Homo sapiens 7680 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363497&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57397837 136967559 CHEMBL1946085 ZINC73199017 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716046 COc1cc(CC2CCCCC2=O)c(Br)c(Br)c1OC InChI=1S/C15H18Br2O3/c1-19-12-8-10(13(16)14(17)15(12)20-2)7-9-5-3-4-6-11(9)18/h8-9H,3-7H2,1-2H3 NIFMHYLFHZVFHS-UHFFFAOYSA-N 50363498 CHEMBL1946086 Carbonic anhydrase 4 Homo sapiens 7420 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363498&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57396029 136967560 CHEMBL1946086 ZINC73199019 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716047 COc1cc(CC2CCCCC2=O)cc(Br)c1OC InChI=1S/C15H19BrO3/c1-18-14-9-10(8-12(16)15(14)19-2)7-11-5-3-4-6-13(11)17/h8-9,11H,3-7H2,1-2H3 LOVSSYPMOZUFIM-UHFFFAOYSA-N 50363499 CHEMBL1946087 Carbonic anhydrase 4 Homo sapiens 7030 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363499&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57399491 136967561 CHEMBL1946087 ZINC73197496 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716048 COc1cc(CC2CCCCC2O)cc(Br)c1OC InChI=1S/C15H21BrO3/c1-18-14-9-10(8-12(16)15(14)19-2)7-11-5-3-4-6-13(11)17/h8-9,11,13,17H,3-7H2,1-2H3 IDQRGCHJUZGJGW-UHFFFAOYSA-N 50363500 CHEMBL1946088 Carbonic anhydrase 4 Homo sapiens 850 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363500&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57334711 136967562 CHEMBL1946088 ZINC73197500 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716050 COc1cc(CC2CCCCC2O)c(Br)c(Br)c1OC InChI=1S/C15H20Br2O3/c1-19-12-8-10(13(16)14(17)15(12)20-2)7-9-5-3-4-6-11(9)18/h8-9,11,18H,3-7H2,1-2H3 FQNQZQJJUNTVIK-UHFFFAOYSA-N 50363501 CHEMBL1946177 Carbonic anhydrase 4 Homo sapiens 930 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363501&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57392368 136967563 CHEMBL1946177 ZINC82154574 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716052 COc1cc(CC2CCCCC2OC(=O)c2cc(cc(c2)[N+]([O-])=O)[N+]([O-])=O)c(Br)c(Br)c1OC InChI=1S/C22H22Br2N2O8/c1-32-18-10-13(19(23)20(24)21(18)33-2)7-12-5-3-4-6-17(12)34-22(27)14-8-15(25(28)29)11-16(9-14)26(30)31/h8-12,17H,3-7H2,1-2H3 XRIPWOSGXFVJPA-UHFFFAOYSA-N 50363502 CHEMBL1946178 Carbonic anhydrase 4 Homo sapiens 1120 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363502&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57395885 136967564 CHEMBL1946178 ZINC82149023 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716053 COc1c(Br)cc(Br)c(Br)c1OC InChI=1S/C8H7Br3O2/c1-12-7-5(10)3-4(9)6(11)8(7)13-2/h3H,1-2H3 RLQZRYRMTTWFCU-UHFFFAOYSA-N 50363489 CHEMBL1946179::hCA inhibitor, 9 Carbonic anhydrase 4 Homo sapiens 163360 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363489&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57399336 136967551 CHEMBL1946179 ZINC82157002 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716054 COc1c(Br)c(Br)c(CO)c(Br)c1OC InChI=1S/C9H9Br3O3/c1-14-8-6(11)4(3-13)5(10)7(12)9(8)15-2/h13H,3H2,1-2H3 VUMVVGRIGBOUHZ-UHFFFAOYSA-N 50363490 CHEMBL1946180::hCA inhibitor, 8 Carbonic anhydrase 4 Homo sapiens 104410 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363490&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57397664 136967552 CHEMBL1946180 ZINC14769547 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716055 COc1ccccc1OC InChI=1S/C8H10O2/c1-9-7-5-3-4-6-8(7)10-2/h3-6H,1-2H3 ABDKAPXRBAPSQN-UHFFFAOYSA-N 50336488 1,2-dimethoxybenzene::CHEMBL1668603 Carbonic anhydrase 4 Homo sapiens 14320 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50336488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50336488&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7043 125086590 59114 CHEMBL1668603 ZINC00388251 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716056 C[C@H]1CCCC[C@H]1O InChI=1S/C7H14O/c1-6-4-2-3-5-7(6)8/h6-8H,2-5H2,1H3/t6-,7+/m0/s1 NDVWOBYBJYUSMF-NKWVEPMBSA-N 36190 (+/-)-cis-2-methylcyclohexanol Carbonic anhydrase 4 Homo sapiens 8430 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36190&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 24006 103147837 52847 ZINC01701828 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716057 CCCC1CCCCC1O InChI=1S/C9H18O/c1-2-5-8-6-3-4-7-9(8)10/h8-10H,2-7H2,1H3 VZBNUCDUQJCIDP-UHFFFAOYSA-N 50363491 CHEMBL1946182 Carbonic anhydrase 4 Homo sapiens 8670 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363491&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 138614 136967553 CHEMBL1946182 ZINC01632736 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716058 CC1CCCCC1=O InChI=1S/C7H12O/c1-6-4-2-3-5-7(6)8/h6H,2-5H2,1H3 LFSAPCRASZRSKS-UHFFFAOYSA-N 7 2-methylcyclohexan-1-one::2-methylcyclohexanone Carbonic anhydrase 4 Homo sapiens 8930 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11419 11108076 52882 ZINC03860605 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716059 NS(=O)(=O)c1ccccc1Br InChI=1S/C6H6BrNO2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,(H2,8,9,10) YSFGGXNLZUSHHS-UHFFFAOYSA-N 50363492 CHEMBL1946184 Carbonic anhydrase 4 Homo sapiens 1430 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363492&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2801263 136967554 CHEMBL1946184 ZINC00157049 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716060 NS(=O)(=O)c1ccccc1 InChI=1S/C6H7NO2S/c7-10(8,9)6-4-2-1-3-5-6/h1-5H,(H2,7,8,9) KHBQMWCZKVMBLN-UHFFFAOYSA-N 12414 CHEMBL27601::benzenesulfonamide::hCA inhibitor, 6 Carbonic anhydrase 4 Homo sapiens 1120 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12414&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search FB2 5NYA,5FZN,4JSZ,4JSA,2WEJ,6LD3,5JAD,4YX4,6GDC 7370 46509667 52916 CHEMBL27601 ZINC00330150 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716061 CCOc1ccc2nc(sc2c1)S(N)(=O)=O InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) OUZWUKMCLIBBOG-UHFFFAOYSA-N 10882 6-ethoxy-1,3-benzothiazole-2-sulfonamide::CHEMBL18::Ethamide::Ethoxazolamide::Ethoxzolamide::Ethoxzolamide (EZA)::Ethoxzolamide, EZM::Sulfonamide, 3::US10172837, Ethoxyzolamide::sulfonamide 3 Carbonic anhydrase 4 Homo sapiens 840 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10882&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EZL 3DD0,5JN9,3CAJ,3MDZ,6BCC,3DCW,6QL2,5TT3,6MWI 3295 46511452 101096 CHEMBL18 DB00311 6814 ZINC00056721 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716062 NS(=O)(=O)Cc1noc2ccccc12 InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12) UBQNRHZMVUUOMG-UHFFFAOYSA-N 10888 1,2-benzoxazol-3-ylmethanesulfonamide::CHEMBL750::SPR_2::US10172837, Zonisamide::Zonisamide::Zonisamide (ZNA)::Zonisamide (ZNS)::Zonisamide, 1::Zonisamide, ZNS Carbonic anhydrase 4 Homo sapiens 38450 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10888&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ZON 3PO7 5734 46511458 10127 CHEMBL750 DB00909 7047 C07504 ZINC00004321 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716075 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 578 ChEMBL 10.1016/j.bmcl.2011.12.069 10.7270/Q2WH2QF4 22230050 Balaydin, HT; Senturk, M; Menzek, A Artvin£oruh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716107 COc1cc2Cc3c([nH]c4ccccc34)-c2c(OC)c1 InChI=1S/C17H15NO2/c1-19-11-7-10-8-13-12-5-3-4-6-14(12)18-17(13)16(10)15(9-11)20-2/h3-7,9,18H,8H2,1-2H3 MMBFXDAGMDPGOJ-UHFFFAOYSA-N 50363533 CHEMBL593037 Carbonic anhydrase 4 Homo sapiens 4852 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363533&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46225608 136967595 CHEMBL593037 ZINC45349254 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716108 C1Oc2cc3Cc4c([nH]c5ccccc45)-c3cc2O1 InChI=1S/C16H11NO2/c1-2-4-13-10(3-1)12-5-9-6-14-15(19-8-18-14)7-11(9)16(12)17-13/h1-4,6-7,17H,5,8H2 YUOJWSJWXUSNJG-UHFFFAOYSA-N 50363534 CHEMBL608978 Carbonic anhydrase 4 Homo sapiens 5341 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363534&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46225609 136967596 CHEMBL608978 ZINC45388428 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716109 Fc1ccc-2c(Cc3c-2[nH]c2ccccc32)c1 InChI=1S/C15H10FN/c16-10-5-6-11-9(7-10)8-13-12-3-1-2-4-14(12)17-15(11)13/h1-7,17H,8H2 JWTKADSGXREMMQ-UHFFFAOYSA-N 50363535 CHEMBL593759 Carbonic anhydrase 4 Homo sapiens 617 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363535&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46225631 136967597 CHEMBL593759 ZINC45350349 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716110 Clc1ccc-2c(Cc3c-2[nH]c2ccccc32)c1 InChI=1S/C15H10ClN/c16-10-5-6-11-9(7-10)8-13-12-3-1-2-4-14(12)17-15(11)13/h1-7,17H,8H2 WTKJHEZXNWTPCS-UHFFFAOYSA-N 50363536 CHEMBL595861 Carbonic anhydrase 4 Homo sapiens 778 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363536&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46225639 136967598 CHEMBL595861 ZINC45352651 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716111 Brc1ccc-2c(Cc3c-2[nH]c2ccccc32)c1 InChI=1S/C15H10BrN/c16-10-5-6-11-9(7-10)8-13-12-3-1-2-4-14(12)17-15(11)13/h1-7,17H,8H2 UDCPKOZAKWHAJJ-UHFFFAOYSA-N 50363537 CHEMBL593667 Carbonic anhydrase 4 Homo sapiens 532 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363537&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46225644 136967599 CHEMBL593667 ZINC45339881 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716112 Oc1cccc-2c1Cc1c-2[nH]c2ccccc12 InChI=1S/C15H11NO/c17-14-7-3-5-10-11(14)8-12-9-4-1-2-6-13(9)16-15(10)12/h1-7,16-17H,8H2 IMGWVISYLAOZSB-UHFFFAOYSA-N 50363538 CHEMBL610454 Carbonic anhydrase 4 Homo sapiens 875 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363538&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46225645 136967600 CHEMBL610454 ZINC45393286 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716113 Oc1ccc-2c(Cc3c-2[nH]c2ccccc32)c1 InChI=1S/C15H11NO/c17-10-5-6-11-9(7-10)8-13-12-3-1-2-4-14(12)16-15(11)13/h1-7,16-17H,8H2 AECQYBVEPFXPNZ-UHFFFAOYSA-N 50363539 CHEMBL593972 Carbonic anhydrase 4 Homo sapiens 912 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363539&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46225646 136967601 CHEMBL593972 ZINC45340212 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716114 Oc1ccc2Cc3c([nH]c4ccccc34)-c2c1 InChI=1S/C15H11NO/c17-10-6-5-9-7-13-11-3-1-2-4-14(11)16-15(13)12(9)8-10/h1-6,8,16-17H,7H2 PGXKTNKPMOJOOZ-UHFFFAOYSA-N 50363540 CHEMBL611504 Carbonic anhydrase 4 Homo sapiens 943 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363540&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46225656 136967602 CHEMBL611504 ZINC45393657 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716115 Oc1cccc2Cc3c([nH]c4ccccc34)-c12 InChI=1S/C15H11NO/c17-13-7-3-4-9-8-11-10-5-1-2-6-12(10)16-15(11)14(9)13/h1-7,16-17H,8H2 NBGIRTVZPOCBPT-UHFFFAOYSA-N 50363541 CHEMBL596276 Carbonic anhydrase 4 Homo sapiens 1032 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363541&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44552472 136967603 CHEMBL596276 ZINC45356149 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716116 Oc1ccc-2c(Cc3c-2[nH]c2ccccc32)c1O InChI=1S/C15H11NO2/c17-13-6-5-9-11(15(13)18)7-10-8-3-1-2-4-12(8)16-14(9)10/h1-6,16-18H,7H2 RQSKTJRARCWUOU-UHFFFAOYSA-N 50363542 CHEMBL596277 Carbonic anhydrase 4 Homo sapiens 543 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363542&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44552473 136967604 CHEMBL596277 ZINC45356684 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716117 Oc1ccc(O)c-2c1Cc1c-2[nH]c2ccccc12 InChI=1S/C15H11NO2/c17-12-5-6-13(18)14-10(12)7-9-8-3-1-2-4-11(8)16-15(9)14/h1-6,16-18H,7H2 ZYYKPVBVJWQNLK-UHFFFAOYSA-N 50363543 CHEMBL593507 Carbonic anhydrase 4 Homo sapiens 435 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363543&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44552559 136967605 CHEMBL593507 ZINC45348802 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716118 Oc1cc2Cc3c([nH]c4ccccc34)-c2cc1O InChI=1S/C15H11NO2/c17-13-6-8-5-11-9-3-1-2-4-12(9)16-15(11)10(8)7-14(13)18/h1-4,6-7,16-18H,5H2 YDURXESSACUHKN-UHFFFAOYSA-N 50363544 CHEMBL594918 Carbonic anhydrase 4 Homo sapiens 842 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363544&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46225672 136967606 CHEMBL594918 ZINC45350030 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716119 Oc1cc2Cc3c([nH]c4ccccc34)-c2c(O)c1 InChI=1S/C15H11NO2/c17-9-5-8-6-11-10-3-1-2-4-12(10)16-15(11)14(8)13(18)7-9/h1-5,7,16-18H,6H2 IABLZJVCQVFTFA-UHFFFAOYSA-N 50363545 CHEMBL607823 Carbonic anhydrase 4 Homo sapiens 765 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363545&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46225673 136967607 CHEMBL607823 ZINC45392255 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716120 COc1ccccc1OC InChI=1S/C8H10O2/c1-9-7-5-3-4-6-8(7)10-2/h3-6H,1-2H3 ABDKAPXRBAPSQN-UHFFFAOYSA-N 50336488 1,2-dimethoxybenzene::CHEMBL1668603 Carbonic anhydrase 4 Homo sapiens 14320 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50336488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50336488&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7043 125086590 59114 CHEMBL1668603 ZINC00388251 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716121 Oc1ccccc1O InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H YCIMNLLNPGFGHC-UHFFFAOYSA-N 26188 α-CA inhibitor, 12::1,2-Dihydroxybenzene, XI::1,2-dihydroxybenzene::CHEMBL280998::benzene-1,2-diol::phenol derivative, 2 Carbonic anhydrase 4 Homo sapiens 10900 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26188&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CAQ 2BUY,2BUQ,4QON,3HHY,2PUM,4ZXT,5KBI,3O4M,6S2H,1DLT,5SWG,7WKM,7WKL,1XEP,3FW4,4K7I,7KK0,7WJR,3T67,7WMB,1KND,7BP1,5VXT,3MI5,5G4H,4OOW 289 56464625 18135 CHEMBL280998 DB02232 C00090 ZINC13512214 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716122 c1cc2ccccc2[nH]1 InChI=1S/C8H7N/c1-2-4-8-7(3-1)5-6-9-8/h1-6,9H SIKJAQJRHWYJAI-UHFFFAOYSA-N 50094702 1H-indole::CHEMBL15844::Indol::Indole, 7::indole Carbonic anhydrase 4 Homo sapiens 2330 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50094702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50094702&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IND 7WGI,5XDD,4EAN,5LVW,3Q8I,185L,7ZHI,1L4H,2P85,7Z94,3SNM,8B05,1UUV,2B24,1EG9,2XVJ,5XDC,4UUJ,1O7N 798 103992578 16881 CHEMBL15844 C00463 ZINC14516984 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716123 C[C@]12CC[C@H]3[C@@H](CCc4cc(OS(N)(=O)=O)ccc34)[C@@H]1CCC2=O InChI=1S/C18H23NO4S/c1-18-9-8-14-13-5-3-12(23-24(19,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16H,2,4,6-9H2,1H3,(H2,19,21,22)/t14-,15-,16+,18+/m1/s1 RVKFQAJIXCZXQY-CBZIJGRNSA-N 50134329 CHEMBL122708::Sulfamic acid (11R,12S,15S,16S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester::Sulfamic acid (8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl ester::estra-1,3,5(10)-trien-17-one-3-sulphamate::estrone3-O-sulfamate Carbonic anhydrase 4 Homo sapiens 1040 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134329&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127676 104024952 CHEMBL122708 ZINC05832614 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716124 CCOc1ccc2nc(sc2c1)S(N)(=O)=O InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) OUZWUKMCLIBBOG-UHFFFAOYSA-N 10882 6-ethoxy-1,3-benzothiazole-2-sulfonamide::CHEMBL18::Ethamide::Ethoxazolamide::Ethoxzolamide::Ethoxzolamide (EZA)::Ethoxzolamide, EZM::Sulfonamide, 3::US10172837, Ethoxyzolamide::sulfonamide 3 Carbonic anhydrase 4 Homo sapiens 840 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10882&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EZL 3DD0,5JN9,3CAJ,3MDZ,6BCC,3DCW,6QL2,5TT3,6MWI 3295 46511452 101096 CHEMBL18 DB00311 6814 ZINC00056721 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716125 NS(=O)(=O)Cc1noc2ccccc12 InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12) UBQNRHZMVUUOMG-UHFFFAOYSA-N 10888 1,2-benzoxazol-3-ylmethanesulfonamide::CHEMBL750::SPR_2::US10172837, Zonisamide::Zonisamide::Zonisamide (ZNA)::Zonisamide (ZNS)::Zonisamide, 1::Zonisamide, ZNS Carbonic anhydrase 4 Homo sapiens 38450 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10888&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ZON 3PO7 5734 46511458 10127 CHEMBL750 DB00909 7047 C07504 ZINC00004321 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716126 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 578 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716233 C1c2ccccc2-c2[nH]c3ccccc3c12 InChI=1S/C15H11N/c1-2-6-11-10(5-1)9-13-12-7-3-4-8-14(12)16-15(11)13/h1-8,16H,9H2 BMGLVVNENOOPFC-UHFFFAOYSA-N 50363546 CHEMBL596060 Carbonic anhydrase 4 Homo sapiens 4736 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363546&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 97598 136967608 CHEMBL596060 ZINC01721888 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716234 COc1cccc-2c1Cc1c-2[nH]c2ccccc12 InChI=1S/C16H13NO/c1-18-15-8-4-6-11-12(15)9-13-10-5-2-3-7-14(10)17-16(11)13/h2-8,17H,9H2,1H3 XYVGWMLAUJRXFE-UHFFFAOYSA-N 50363547 CHEMBL607813 Carbonic anhydrase 4 Homo sapiens 4215 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363547&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11579563 136967609 CHEMBL607813 ZINC35855511 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716235 COc1ccc-2c(Cc3c-2[nH]c2ccccc32)c1 InChI=1S/C16H13NO/c1-18-11-6-7-12-10(8-11)9-14-13-4-2-3-5-15(13)17-16(12)14/h2-8,17H,9H2,1H3 IWYYMIXXPNSHBD-UHFFFAOYSA-N 50363548 CHEMBL610455 Carbonic anhydrase 4 Homo sapiens 4442 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363548&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11322287 136967610 CHEMBL610455 ZINC45393289 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716236 COc1ccc2Cc3c([nH]c4ccccc34)-c2c1 InChI=1S/C16H13NO/c1-18-11-7-6-10-8-14-12-4-2-3-5-15(12)17-16(14)13(10)9-11/h2-7,9,17H,8H2,1H3 OHJHKPQQIDHAEA-UHFFFAOYSA-N 50363549 CHEMBL593276 Carbonic anhydrase 4 Homo sapiens 4627 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363549&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11183936 136967611 CHEMBL593276 ZINC38339758 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716237 COc1ccc-2c(Cc3c-2[nH]c2ccccc32)c1OC InChI=1S/C17H15NO2/c1-19-15-8-7-11-13(17(15)20-2)9-12-10-5-3-4-6-14(10)18-16(11)12/h3-8,18H,9H2,1-2H3 HXUVQFMDYLJGLX-UHFFFAOYSA-N 50363550 CHEMBL607824 Carbonic anhydrase 4 Homo sapiens 4082 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363550&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11701693 136967612 CHEMBL607824 ZINC38276930 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716238 COc1ccc(OC)c-2c1Cc1c-2[nH]c2ccccc12 InChI=1S/C17H15NO2/c1-19-14-7-8-15(20-2)16-12(14)9-11-10-5-3-4-6-13(10)18-17(11)16/h3-8,18H,9H2,1-2H3 BQCBITRXCKSWAA-UHFFFAOYSA-N 50363551 CHEMBL594224 Carbonic anhydrase 4 Homo sapiens 5726 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363551&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11637531 136967613 CHEMBL594224 ZINC35976816 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50716239 COc1cc2Cc3c([nH]c4ccccc34)-c2cc1OC InChI=1S/C17H15NO2/c1-19-15-8-10-7-13-11-5-3-4-6-14(11)18-17(13)12(10)9-16(15)20-2/h3-6,8-9,18H,7H2,1-2H3 IXKSTMMYYGJGBF-UHFFFAOYSA-N 50363552 CHEMBL611502 Carbonic anhydrase 4 Homo sapiens 4573 ChEMBL 10.1016/j.ejmech.2011.12.022 10.7270/Q2N0170S 22245047 Ekinci, D; Cavdar, H; Durdagi, S; Talaz, O; Senturk, M; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363552&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12140130 136967614 CHEMBL611502 ZINC38875423 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50721863 CC[Hg]Sc1ccccc1C(O)=O InChI=1S/C7H6O2S.C2H5.Hg/c8-7(9)5-3-1-2-4-6(5)10;1-2;/h1-4,10H,(H,8,9);1H2,2H3;/q;;+1/p-1 HXQVQGWHFRNKMS-UHFFFAOYSA-M 50366032 THIOMEROSAL Carbonic anhydrase 4 Homo sapiens 5610 ChEMBL 10.1016/j.bmcl.2012.01.129 10.7270/Q2FJ2H78 22365761 Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366032&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EMT 3A0W,1KDG,2YPD,4GSR,1O9L 67361 136970094 33214 DB02731 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50721864 CC[Hg]Sc1ccccc1C(O)=O InChI=1S/C7H6O2S.C2H5.Hg/c8-7(9)5-3-1-2-4-6(5)10;1-2;/h1-4,10H,(H,8,9);1H2,2H3;/q;;+1/p-1 HXQVQGWHFRNKMS-UHFFFAOYSA-M 50366032 THIOMEROSAL Carbonic anhydrase 4 Homo sapiens 5610 ChEMBL 10.1016/j.bmcl.2012.01.129 10.7270/Q2FJ2H78 22365761 Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366032&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EMT 3A0W,1KDG,2YPD,4GSR,1O9L 67361 136970094 33214 DB02731 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50721876 O=c1ccc2ccccc2o1 InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 12342 2H-chromen-2-one::CHEMBL6466::Coumarin Carbonic anhydrase 4 Homo sapiens 62300 ChEMBL 10.1016/j.bmcl.2012.01.129 10.7270/Q2FJ2H78 22365761 Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12342&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search COU 2PMJ,2H90,3L5M,3L68,3L66,3CRB,1Z10,4UTI,4UTL,2PWB 323 172097204 28794 CHEMBL6466 DB04665 C05851 ZINC00074709 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50721883 CCOP(=S)(OCC)Oc1ccc2c(C)c(Cl)c(=O)oc2c1 InChI=1S/C14H16ClO5PS/c1-4-17-21(22,18-5-2)20-10-6-7-11-9(3)13(15)14(16)19-12(11)8-10/h6-8H,4-5H2,1-3H3 BXNANOICGRISHX-UHFFFAOYSA-N 50366033 ASUNTOL Carbonic anhydrase 4 Homo sapiens 5480 ChEMBL 10.1016/j.bmcl.2012.01.129 10.7270/Q2FJ2H78 22365761 Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366033&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2871 136970095 3903 C11025 ZINC00608284 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50721903 O=c1ccc2ccccc2[nH]1 InChI=1S/C9H7NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11) LISFMEBWQUVKPJ-UHFFFAOYSA-N 50366034 CHEMBL186422 Carbonic anhydrase 4 Homo sapiens 360 ChEMBL 10.1016/j.bmcl.2012.01.129 10.7270/Q2FJ2H78 22365761 Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366034&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search OCH 7RIZ,1Z03,3SRG 6038 136970096 18289 CHEMBL186422 DB04745 C06415 ZINC08579298 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50721904 O=c1ccc2ccccc2[nH]1 InChI=1S/C9H7NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11) LISFMEBWQUVKPJ-UHFFFAOYSA-N 50366034 CHEMBL186422 Carbonic anhydrase 4 Homo sapiens 360 ChEMBL 10.1016/j.bmcl.2012.01.129 10.7270/Q2FJ2H78 22365761 Carta, F; Vullo, D; Maresca, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366034&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search OCH 7RIZ,1Z03,3SRG 6038 136970096 18289 CHEMBL186422 DB04745 C06415 ZINC08579298 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734619 Nc1ccc(cc1Br)S(N)(=O)=O InChI=1S/C6H7BrN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11) KQEVQYJWCZRLTJ-UHFFFAOYSA-N 10864 4-Amino-3-bromobenzenesulfonamide::4-amino-3-bromobenzene-1-sulfonamide::CHEMBL6724::aromatic/heteroaromatic sulfonamide 9::halogenosulfanilamide deriv. 5d Carbonic anhydrase 4 Homo sapiens 66 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10864&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3526523 46511436 CHEMBL6724 ZINC12522340 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734621 NS(=O)(=O)c1nc2ccc(OCCO)cc2s1 InChI=1S/C9H10N2O4S2/c10-17(13,14)9-11-7-2-1-6(15-4-3-12)5-8(7)16-9/h1-2,5,12H,3-4H2,(H2,10,13,14) XIFUCWWEBDMYEV-UHFFFAOYSA-N 50079049 6-(2-Hydroxy-ethoxy)-benzothiazole-2-sulfonic acid amide::6-(2-Hydroxyethoxy)benzo[d]thiazole-2-sulfonamide::CHEMBL287117 Carbonic anhydrase 4 Homo sapiens 15 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079049&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 94706 103971398 CHEMBL287117 ZINC01915737 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734622 NS(=O)(=O)c1ccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)c(I)c1 InChI=1S/C20H28IN5O11S/c21-14-7-13(38(22,36)37)1-2-15(14)23-16(27)8-25(10-18(30)31)5-3-24(9-17(28)29)4-6-26(11-19(32)33)12-20(34)35/h1-2,7H,3-6,8-12H2,(H,23,27)(H,28,29)(H,30,31)(H,32,33)(H,34,35)(H2,22,36,37) LYRVWUJVQWBERF-UHFFFAOYSA-N 50097282 (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(2-iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid::CHEMBL32982::{(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-[(2-iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 29 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097282&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11017835 103994614 CHEMBL32982 ZINC29229174 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734626 NS(=O)(=O)c1ccc(CNC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)NCc2ccc(cc2)S(N)(=O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C28H39N7O12S2/c29-48(44,45)22-5-1-20(2-6-22)13-31-24(36)15-34(18-27(40)41)11-9-33(17-26(38)39)10-12-35(19-28(42)43)16-25(37)32-14-21-3-7-23(8-4-21)49(30,46)47/h1-8H,9-19H2,(H,31,36)(H,32,37)(H,38,39)(H,40,41)(H,42,43)(H2,29,44,45)(H2,30,46,47) RSPXQWLZLVDDAI-UHFFFAOYSA-N 50097276 CHEMBL286449::Zinc: {{2-[Carboxymethyl-(2-{carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-acetic acid::{{2-[Carboxymethyl-(2-{carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-acetic acid; compound with Zn complex::{{2-[carboxymethyl-(2-{carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 37 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097276&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3542746 103994608 CHEMBL286449 ZINC34717929 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734627 NS(=O)(=O)c1ccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)Nc2ccc(cc2)S(N)(=O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C26H35N7O12S2/c27-46(42,43)20-5-1-18(2-6-20)29-22(34)13-32(16-25(38)39)11-9-31(15-24(36)37)10-12-33(17-26(40)41)14-23(35)30-19-3-7-21(8-4-19)47(28,44)45/h1-8H,9-17H2,(H,29,34)(H,30,35)(H,36,37)(H,38,39)(H,40,41)(H2,27,42,43)(H2,28,44,45) KPZSOSRRNOIKIF-UHFFFAOYSA-N 50097280 CHEMBL284694::V{{2-[Carboxymethyl-(2-{carboxymethyl-[(4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid::Zinc; {{2-[Carboxymethyl-(2-{carboxymethyl-[(4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid::{{2-[Carboxymethyl-(2-{carboxymethyl-[(4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid::{{2-[Carboxymethyl-(2-{carboxymethyl-[(4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid; compound with Zn complex Carbonic anhydrase 4 Homo sapiens 156 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097280&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5071527 103994612 CHEMBL284694 ZINC34717927 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734630 NS(=O)(=O)c1cc(c(NC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)c(Cl)c1Cl)S(N)(=O)=O InChI=1S/C20H28Cl2N6O13S2/c21-18-11(42(23,38)39)5-12(43(24,40)41)20(19(18)22)25-13(29)6-27(8-15(32)33)3-1-26(7-14(30)31)2-4-28(9-16(34)35)10-17(36)37/h5H,1-4,6-10H2,(H,25,29)(H,30,31)(H,32,33)(H,34,35)(H,36,37)(H2,23,38,39)(H2,24,40,41) GMFZVVNOWSRWGU-UHFFFAOYSA-N 50097274 (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(2,3-dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid::CHEMBL284617::{(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-[(2,3-dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 36 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097274&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11093710 103994606 CHEMBL284617 ZINC34717920 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734635 NS(=O)(=O)c1ccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)Nc2ccc(cc2Cl)S(N)(=O)=O)CC(O)=O)CC(O)=O)c(Cl)c1 InChI=1S/C26H33Cl2N7O12S2/c27-18-9-16(48(29,44)45)1-3-20(18)31-22(36)11-34(14-25(40)41)7-5-33(13-24(38)39)6-8-35(15-26(42)43)12-23(37)32-21-4-2-17(10-19(21)28)49(30,46)47/h1-4,9-10H,5-8,11-15H2,(H,31,36)(H,32,37)(H,38,39)(H,40,41)(H,42,43)(H2,29,44,45)(H2,30,46,47) FDQVIZWYDGHVRY-UHFFFAOYSA-N 50097291 CHEMBL284398::{{2-[Carboxymethyl-(2-{carboxymethyl-[(2-chloro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(2-chloro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 27 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097291&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10887220 103994623 CHEMBL284398 ZINC95608712 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734639 NS(=O)(=O)c1ccc(COC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C21H30N4O12S/c22-38(35,36)16-3-1-15(2-4-16)14-37-21(34)13-25(12-20(32)33)8-6-23(9-17(26)27)5-7-24(10-18(28)29)11-19(30)31/h1-4H,5-14H2,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H2,22,35,36) WIYSUXBFHUQGRS-UHFFFAOYSA-N 50097292 CHEMBL34974::[(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-(4-sulfamoyl-benzyloxycarbonylmethyl)-amino]-acetic acid Carbonic anhydrase 4 Homo sapiens 265 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097292&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10864662 103994624 CHEMBL34974 ZINC29250726 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734640 NS(=O)(=O)c1ccc(CCO)cc1 InChI=1S/C8H11NO3S/c9-13(11,12)8-3-1-7(2-4-8)5-6-10/h1-4,10H,5-6H2,(H2,9,11,12) RYKHXKKLCRPAJP-UHFFFAOYSA-N 10877 4-(2-hydroxyethyl)benzene-1-sulfonamide::CHEMBL6784::JMC522226 Compound 21::JMC523116 Compound 21::aromatic/heteroaromatic sulfonamide 22 Carbonic anhydrase 4 Homo sapiens 450 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10877&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search S2O 6RG5,4YYT 10375558 46511448 CHEMBL6784 ZINC13442505 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734642 NNc1ccc(cc1)S(N)(=O)=O InChI=1S/C6H9N3O2S/c7-9-5-1-3-6(4-2-5)12(8,10)11/h1-4,9H,7H2,(H2,8,10,11) NBJSNAGTUCWQRO-UHFFFAOYSA-N 10858 4-hydrazinylbenzene-1-sulfonamide::CHEMBL7204::aromatic/heteroaromatic sulfonamide 3::hydrazide deriv. 14 Carbonic anhydrase 4 Homo sapiens 3200 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10858&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 78105 46511430 CHEMBL7204 ZINC00152965 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734649 NS(=O)(=O)c1ccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C20H29N5O11S/c21-37(35,36)15-3-1-14(2-4-15)22-16(26)9-24(11-18(29)30)7-5-23(10-17(27)28)6-8-25(12-19(31)32)13-20(33)34/h1-4H,5-13H2,(H,22,26)(H,27,28)(H,29,30)(H,31,32)(H,33,34)(H2,21,35,36) LCCYHYMLBZWLLE-UHFFFAOYSA-N 50097296 (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid::CHEMBL32836 Carbonic anhydrase 4 Homo sapiens 180 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097296&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11763331 103994628 CHEMBL32836 ZINC29234784 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734650 NS(=O)(=O)c1nc2ccc(OC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)cc2s1 InChI=1S/C21H27N5O12S2/c22-40(36,37)21-23-14-2-1-13(7-15(14)39-21)38-20(35)12-26(11-19(33)34)6-4-24(8-16(27)28)3-5-25(9-17(29)30)10-18(31)32/h1-2,7H,3-6,8-12H2,(H,27,28)(H,29,30)(H,31,32)(H,33,34)(H2,22,36,37) GFUKHIMMBLMJDN-UHFFFAOYSA-N 50097298 CHEMBL34317::[(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-(2-sulfamoyl-benzothiazol-6-yloxycarbonylmethyl)-amino]-acetic acid Carbonic anhydrase 4 Homo sapiens 6 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097298&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11039314 103994630 CHEMBL34317 ZINC29247285 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734651 Nc1ccc(cc1I)S(N)(=O)=O InChI=1S/C6H7IN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11) HCODCRHNVCTCTR-UHFFFAOYSA-N 10865 4-Amino-3-iodobenzenesulfonamide::4-amino-3-iodobenzene-1-sulfonamide::CHEMBL268177::aromatic/heteroaromatic sulfonamide 10::halogenosulfanilamide deriv. 5e Carbonic anhydrase 4 Homo sapiens 125 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10865&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 9861037 46511437 CHEMBL268177 ZINC13442499 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734656 NS(=O)(=O)c1cc(c(NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)Nc2cc(Cl)c(cc2S(N)(=O)=O)S(N)(=O)=O)CC(O)=O)CC(O)=O)cc1Cl)S(N)(=O)=O InChI=1S/C26H35Cl2N9O16S4/c27-14-5-16(20(56(31,50)51)7-18(14)54(29,46)47)33-22(38)9-36(12-25(42)43)3-1-35(11-24(40)41)2-4-37(13-26(44)45)10-23(39)34-17-6-15(28)19(55(30,48)49)8-21(17)57(32,52)53/h5-8H,1-4,9-13H2,(H,33,38)(H,34,39)(H,40,41)(H,42,43)(H,44,45)(H2,29,46,47)(H2,30,48,49)(H2,31,50,51)(H2,32,52,53) JWOPUHDTBVCEEZ-UHFFFAOYSA-N 50097283 CHEMBL284831::{{2-[Carboxymethyl-(2-{carboxymethyl-[(5-chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(5-chloro-2,4-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 41 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097283&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5227639 103994615 CHEMBL284831 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734660 NS(=O)(=O)c1ccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)Nc2ccc(cc2I)S(N)(=O)=O)CC(O)=O)CC(O)=O)c(I)c1 InChI=1S/C26H33I2N7O12S2/c27-18-9-16(48(29,44)45)1-3-20(18)31-22(36)11-34(14-25(40)41)7-5-33(13-24(38)39)6-8-35(15-26(42)43)12-23(37)32-21-4-2-17(10-19(21)28)49(30,46)47/h1-4,9-10H,5-8,11-15H2,(H,31,36)(H,32,37)(H,38,39)(H,40,41)(H,42,43)(H2,29,44,45)(H2,30,46,47) SGIZOAVXYNPFQX-UHFFFAOYSA-N 50097301 CHEMBL30168::{{2-[Carboxymethyl-(2-{carboxymethyl-[(2-iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(2-iodo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 24 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097301&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11967472 103994633 CHEMBL30168 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734661 NS(=O)(=O)c1nnc(NC(=O)CCNC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)s1 InChI=1S/C19H30N8O12S2/c20-41(38,39)19-24-23-18(40-19)22-12(28)1-2-21-13(29)7-26(9-15(32)33)5-3-25(8-14(30)31)4-6-27(10-16(34)35)11-17(36)37/h1-11H2,(H,21,29)(H,30,31)(H,32,33)(H,34,35)(H,36,37)(H2,20,38,39)(H,22,23,28) ONKCOSCHJAFALI-UHFFFAOYSA-N 50097302 CHEMBL416410::[Carboxymethyl-(2-{carboxymethyl-[2-(carboxymethyl-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-amino]-acetic acid Carbonic anhydrase 4 Homo sapiens 16 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097302&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11966600 103994634 CHEMBL416410 ZINC34717924 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734667 NS(=O)(=O)c1nc2ccc(OCCOC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)OCCOc3ccc4nc(sc4c3)S(N)(=O)=O)CC(O)=O)CC(O)=O)cc2s1 InChI=1S/C32H39N7O16S4/c33-58(48,49)31-35-22-3-1-20(13-24(22)56-31)52-9-11-54-29(46)18-38(16-27(42)43)7-5-37(15-26(40)41)6-8-39(17-28(44)45)19-30(47)55-12-10-53-21-2-4-23-25(14-21)57-32(36-23)59(34,50)51/h1-4,13-14H,5-12,15-19H2,(H,40,41)(H,42,43)(H,44,45)(H2,33,48,49)(H2,34,50,51) ZZLLLCNRSQXFHU-UHFFFAOYSA-N 50097303 CHEMBL346691::{{2-[Carboxymethyl-(2-{carboxymethyl-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-amino}-ethyl)-amino]-ethyl}-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 4 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097303&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11083515 103994635 CHEMBL346691 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734673 NS(=O)(=O)c1nc2ccc(OC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)Oc3ccc4nc(sc4c3)S(N)(=O)=O)CC(O)=O)CC(O)=O)cc2s1 InChI=1S/C28H31N7O14S4/c29-52(44,45)27-31-18-3-1-16(9-20(18)50-27)48-25(42)14-34(12-23(38)39)7-5-33(11-22(36)37)6-8-35(13-24(40)41)15-26(43)49-17-2-4-19-21(10-17)51-28(32-19)53(30,46)47/h1-4,9-10H,5-8,11-15H2,(H,36,37)(H,38,39)(H,40,41)(H2,29,44,45)(H2,30,46,47) BWFWKLRLHQZLAB-UHFFFAOYSA-N 50097307 CHEMBL408856::[[2-(Carboxymethyl-{2-[carboxymethyl-(2-sulfamoyl-benzothiazol-6-yloxycarbonylmethyl)-amino]-ethyl}-amino)-ethyl]-(2-sulfamoyl-benzothiazol-6-yloxycarbonylmethyl)-amino]-acetic acid Carbonic anhydrase 4 Homo sapiens 5 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097307&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10996432 103994639 CHEMBL408856 ZINC95543437 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734677 NS(=O)(=O)c1nnc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)Nc2nnc(s2)S(N)(=O)=O)CC(O)=O)CC(O)=O)s1 InChI=1S/C18H27N11O12S4/c19-44(38,39)17-25-23-15(42-17)21-10(30)5-28(8-13(34)35)3-1-27(7-12(32)33)2-4-29(9-14(36)37)6-11(31)22-16-24-26-18(43-16)45(20,40)41/h1-9H2,(H,32,33)(H,34,35)(H,36,37)(H2,19,38,39)(H2,20,40,41)(H,21,23,30)(H,22,24,31) ABKUNMXQTDTBPW-UHFFFAOYSA-N 50097287 CHEMBL432083::Zinc{{2-[Carboxymethyl-(2-{carboxymethyl-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-acetic acid::{{2-[Carboxymethyl-(2-{carboxymethyl-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-acetic acid::{{2-[Carboxymethyl-(2-{carboxymethyl-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-acetic acid; compound with Cu complex::{{2-[Carboxymethyl-(2-{carboxymethyl-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-acetic acid;compound with Al complex::{{2-[Carboxymethyl-(2-{carboxymethyl-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-acetic acid;compound with Zn complex Carbonic anhydrase 4 Homo sapiens 7 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097287&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5172319 103994619 CHEMBL432083 ZINC34717925 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734678 NS(=O)(=O)c1ccc(CNC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C21H31N5O11S/c22-38(36,37)16-3-1-15(2-4-16)9-23-17(27)10-25(12-19(30)31)7-5-24(11-18(28)29)6-8-26(13-20(32)33)14-21(34)35/h1-4H,5-14H2,(H,23,27)(H,28,29)(H,30,31)(H,32,33)(H,34,35)(H2,22,36,37) ZPMBSIXINYNCIS-UHFFFAOYSA-N 50097305 (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(4-sulfamoyl-benzylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid::CHEMBL286297 Carbonic anhydrase 4 Homo sapiens 40 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097305&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10907843 103994637 CHEMBL286297 ZINC29246553 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734679 NS(=O)(=O)c1ccccc1NC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O InChI=1S/C20H29N5O11S/c21-37(35,36)15-4-2-1-3-14(15)22-16(26)9-24(11-18(29)30)7-5-23(10-17(27)28)6-8-25(12-19(31)32)13-20(33)34/h1-4H,5-13H2,(H,22,26)(H,27,28)(H,29,30)(H,31,32)(H,33,34)(H2,21,35,36) XLUJNNWFCWZEFT-UHFFFAOYSA-N 50097284 (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(2-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid::CHEMBL289672 Carbonic anhydrase 4 Homo sapiens 550 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097284&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11028005 103994616 CHEMBL289672 ZINC29246265 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734681 Cn1nc(sc1=NC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)S(N)(=O)=O InChI=1S/C17H27N7O11S2/c1-21-16(36-17(20-21)37(18,34)35)19-11(25)6-23(8-13(28)29)4-2-22(7-12(26)27)3-5-24(9-14(30)31)10-15(32)33/h2-10H2,1H3,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H2,18,34,35) BUPGPOBWZWXNCY-UHFFFAOYSA-N 50097295 (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid::CHEMBL289888::[Carboxymethyl-(2-{carboxymethyl-[2-(carboxymethyl-{[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenecarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-amino]-acetic acid Carbonic anhydrase 4 Homo sapiens 19 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097295&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11060833 103994627 CHEMBL289888 ZINC29230558 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734686 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 IAVUPMFITXYVAF-XPUUQOCRSA-N 10884 (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide::Dorzolamide (DRZ)::Dorzolamide (DZA) Carbonic anhydrase 4 Homo sapiens 43 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10884&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ETS 4M2W,4M2U,4K13,3FW3,6BC9,1CIL 5284549 46511454 4702 DB00869 6810 C06969 ZINC01530621 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734688 Cn1nc(sc1=NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)N=c1sc(nn1C)S(N)(=O)=O)CC(O)=O)CC(O)=O)S(N)(=O)=O InChI=1S/C20H31N11O12S4/c1-27-17(44-19(25-27)46(21,40)41)23-12(32)7-30(10-15(36)37)5-3-29(9-14(34)35)4-6-31(11-16(38)39)8-13(33)24-18-28(2)26-20(45-18)47(22,42)43/h3-11H2,1-2H3,(H,34,35)(H,36,37)(H,38,39)(H2,21,40,41)(H2,22,42,43) XBLYYDDTTORRLT-UHFFFAOYSA-N 50097289 ((2-{Carboxymethyl-[2-(carboxymethyl-{[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2Z)-ylidenecarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-{[3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-(2E)-ylidenecarbamoyl]-methyl}-amino)-acetic acid::CHEMBL154106::CHEMBL1795056::CHEMBL35367::Zinc; {{2-[Carboxymethyl-(2-{carboxymethyl-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(3-methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidenecarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 9 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097289&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11147037 103994621 CHEMBL1795056CHEMBL154106CHEMBL35367 ZINC95564389 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734695 Nc1ccc(cc1F)S(N)(=O)=O InChI=1S/C6H7FN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11) HVFBADWBKHAPKV-UHFFFAOYSA-N 10862 4-Amino-3-fluorobenzenesulfonamide::4-amino-3-fluorobenzene-1-sulfonamide::CHEMBL6853::aromatic/heteroaromatic sulfonamide 7::halogenosulfanilamide deriv. 5b Carbonic anhydrase 4 Homo sapiens 180 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10862&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4687472 46511434 CHEMBL6853 ZINC06925827 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734696 NS(=O)(=O)c1cccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)Nc2cccc(c2)S(N)(=O)=O)CC(O)=O)CC(O)=O)c1 InChI=1S/C26H35N7O12S2/c27-46(42,43)20-5-1-3-18(11-20)29-22(34)13-32(16-25(38)39)9-7-31(15-24(36)37)8-10-33(17-26(40)41)14-23(35)30-19-4-2-6-21(12-19)47(28,44)45/h1-6,11-12H,7-10,13-17H2,(H,29,34)(H,30,35)(H,36,37)(H,38,39)(H,40,41)(H2,27,42,43)(H2,28,44,45) WUXVVCVUHCWYDL-UHFFFAOYSA-N 50097308 CHEMBL287145::{{2-[carboxymethyl-(2-{carboxymethyl-[(3-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(3-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 425 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097308&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10919571 103994640 CHEMBL287145 ZINC34717922 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734699 NS(=O)(=O)c1ccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)c(Cl)c1 InChI=1S/C20H28ClN5O11S/c21-14-7-13(38(22,36)37)1-2-15(14)23-16(27)8-25(10-18(30)31)5-3-24(9-17(28)29)4-6-26(11-19(32)33)12-20(34)35/h1-2,7H,3-6,8-12H2,(H,23,27)(H,28,29)(H,30,31)(H,32,33)(H,34,35)(H2,22,36,37) ZORQOONYDJHKIO-UHFFFAOYSA-N 50097281 (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(2-chloro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid::CHEMBL32160::{(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-[(2-chloro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 32 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097281&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11039158 103994613 CHEMBL32160 ZINC29230900 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734706 NS(=O)(=O)c1nc2ccc(O)cc2s1 InChI=1S/C7H6N2O3S2/c8-14(11,12)7-9-5-2-1-4(10)3-6(5)13-7/h1-3,10H,(H2,8,11,12) NOOBQTYVTDBXTL-UHFFFAOYSA-N 10874 6-hydroxy-1,3-benzothiazole-2-sulfonamide::CHEMBL6685::aromatic/heteroaromatic sulfonamide 19 Carbonic anhydrase 4 Homo sapiens 17 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10874&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ZEC 3L5U,1ZFQ 6852129 46511445 CHEMBL6685 DB08765 ZINC13442501 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734710 Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) FDDDEECHVMSUSB-UHFFFAOYSA-N 10857 4-aminobenzene-1-sulfonamide::CHEMBL21::Sulfanilamide::aromatic sulfonamide compound 5::aromatic/heteroaromatic sulfonamide 2::halogenosulfanilamide deriv. 5a Carbonic anhydrase 4 Homo sapiens 3000 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10857&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SAN 8BCB,1AJ0,4F93,4F92,4COQ,6RL9 5333 46511429 45373 CHEMBL21 DB00259 C07458 ZINC00002101 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734713 NS(=O)(=O)c1ccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)c(F)c1 InChI=1S/C20H28FN5O11S/c21-14-7-13(38(22,36)37)1-2-15(14)23-16(27)8-25(10-18(30)31)5-3-24(9-17(28)29)4-6-26(11-19(32)33)12-20(34)35/h1-2,7H,3-6,8-12H2,(H,23,27)(H,28,29)(H,30,31)(H,32,33)(H,34,35)(H2,22,36,37) FHNZWFOGLWAHBK-UHFFFAOYSA-N 50097285 (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid::CHEMBL32732::{(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-[(2-fluoro-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 29 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097285&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11146161 103994617 CHEMBL32732 ZINC29230905 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734715 Nc1nnc(s1)S(N)(=O)=O InChI=1S/C2H4N4O2S2/c3-1-5-6-2(9-1)10(4,7)8/h(H2,3,5)(H2,4,7,8) VGMVBPQOACUDRU-UHFFFAOYSA-N 10868 1,3,4-Thiadiazole-2-sulfonamide, 6::1,3,4-thiadiazole-2-sulfonamide 15::5-Amino-1,3,4-thiadiazole-2-sulphonamide (1)::5-amino-1,3,4-thiadiazole-2-sulfonamide::CHEMBL265674::aromatic/heteroaromatic sulfonamide 13 Carbonic anhydrase 4 Homo sapiens 540 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10868&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1SA 2HNC,5TUO 84724 46509349 CHEMBL265674 ZINC16969869 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734716 NS(=O)(=O)c1ccc(CCOC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)OCCc2ccc(cc2)S(N)(=O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C30H41N5O14S2/c31-50(44,45)24-5-1-22(2-6-24)9-15-48-29(42)20-34(18-27(38)39)13-11-33(17-26(36)37)12-14-35(19-28(40)41)21-30(43)49-16-10-23-3-7-25(8-4-23)51(32,46)47/h1-8H,9-21H2,(H,36,37)(H,38,39)(H,40,41)(H2,31,44,45)(H2,32,46,47) DWMKRKRXPAXKQB-UHFFFAOYSA-N 50097306 CHEMBL35385::{{2-[Carboxymethyl-(2-{carboxymethyl-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-ethyl)-amino]-ethyl}-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 115 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097306&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11735346 103994638 CHEMBL35385 ZINC95613317 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734717 CC(=O)N=c1sc(nn1C)S(N)(=O)=O InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) FLOSMHQXBMRNHR-UHFFFAOYSA-N 10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid_4100::sulfonamide 2 Carbonic anhydrase 4 Homo sapiens 240 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10881&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search MZM 4K0Z,4YHA,5KU6,1BZM,5C8I,3DAZ,3DCS 4100 46511451 CHEMBL288100 6828 ZINC12503151 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734720 NCc1ccc(cc1)S(N)(=O)=O InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11) TYMRLRRVMHJFTF-UHFFFAOYSA-N 10860 4-(aminomethyl)benzene-1-sulfonamide::CHEMBL419::MAFENIDE::aromatic sulfonamide compound 6::aromatic/heteroaromatic sulfonamide 5::hCA inhibitor, 9 Carbonic anhydrase 4 Homo sapiens 2800 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10860&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 6LH 5JNC 3998 46511432 CHEMBL419 DB06795 C07106 ZINC00001644 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734721 NS(=O)(=O)c1nc2ccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)cc2s1 InChI=1S/C21H28N6O11S2/c22-40(37,38)21-24-14-2-1-13(7-15(14)39-21)23-16(28)8-26(10-18(31)32)5-3-25(9-17(29)30)4-6-27(11-19(33)34)12-20(35)36/h1-2,7H,3-6,8-12H2,(H,23,28)(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H2,22,37,38) QTRPSCXVKWWSNO-UHFFFAOYSA-N 50097309 (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid::CHEMBL415466::{(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-[(2-sulfamoyl-benzothiazol-6-ylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 9 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097309&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11082579 103994641 CHEMBL415466 ZINC29246545 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734724 Cn1nc(sc1=N)S(N)(=O)=O InChI=1S/C3H6N4O2S2/c1-7-2(4)10-3(6-7)11(5,8)9/h4H,1H3,(H2,5,8,9) BWSMJWLWXNCHHP-UHFFFAOYSA-N 10869 5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide::CHEMBL6753::aromatic/heteroaromatic sulfonamide 14 Carbonic anhydrase 4 Homo sapiens 355 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10869&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5172475 46511440 CHEMBL6753 ZINC05423825 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734727 NS(=O)(=O)c1cccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)c1 InChI=1S/C20H29N5O11S/c21-37(35,36)15-3-1-2-14(8-15)22-16(26)9-24(11-18(29)30)6-4-23(10-17(27)28)5-7-25(12-19(31)32)13-20(33)34/h1-3,8H,4-7,9-13H2,(H,22,26)(H,27,28)(H,29,30)(H,31,32)(H,33,34)(H2,21,35,36) NIOHYKBDYABMQO-UHFFFAOYSA-N 50097310 (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(3-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid::CHEMBL36525 Carbonic anhydrase 4 Homo sapiens 500 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097310&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11017060 103994642 CHEMBL36525 ZINC29234897 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734733 Nc1ccc2nc(sc2c1)S(N)(=O)=O InChI=1S/C7H7N3O2S2/c8-4-1-2-5-6(3-4)13-7(10-5)14(9,11)12/h1-3H,8H2,(H2,9,11,12) OFSGGVHHSMAUEI-UHFFFAOYSA-N 50079035 6-Amino-benzothiazole-2-sulfonic acid amide::6-aminobenzo[d]thiazole-2-sulfonamide::CHEMBL35118 Carbonic anhydrase 4 Homo sapiens 19 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079035&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 93505 103971384 CHEMBL35118 ZINC05162075 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734740 NS(=O)(=O)c1nnc(NC(=O)CCNC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)NCCC(=O)Nc2nnc(s2)S(N)(=O)=O)CC(O)=O)CC(O)=O)s1 InChI=1S/C24H37N13O14S4/c25-54(48,49)23-33-31-21(52-23)29-14(38)1-3-27-16(40)9-36(12-19(44)45)7-5-35(11-18(42)43)6-8-37(13-20(46)47)10-17(41)28-4-2-15(39)30-22-32-34-24(53-22)55(26,50)51/h1-13H2,(H,27,40)(H,28,41)(H,42,43)(H,44,45)(H,46,47)(H2,25,48,49)(H2,26,50,51)(H,29,31,38)(H,30,32,39) NJIYCMKWBWEALF-UHFFFAOYSA-N 50097288 ((2-{Carboxymethyl-[2-(carboxymethyl-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-{[2-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-ethylcarbamoyl]-methyl}-amino)-acetic acid::CHEMBL285516 Carbonic anhydrase 4 Homo sapiens 8 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097288&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11828964 103994620 CHEMBL285516 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734742 NS(=O)(=O)c1ccc(CCNC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C22H33N5O11S/c23-39(37,38)17-3-1-16(2-4-17)5-6-24-18(28)11-26(13-20(31)32)9-7-25(12-19(29)30)8-10-27(14-21(33)34)15-22(35)36/h1-4H,5-15H2,(H,24,28)(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H2,23,37,38) PHFFXGUUXGOEQY-UHFFFAOYSA-N 50097304 CHEMBL32096::[Carboxymethyl-(2-{carboxymethyl-[2-(carboxymethyl-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-amino}-ethyl)-amino]-acetic acid Carbonic anhydrase 4 Homo sapiens 36 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097304&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11060882 103994636 CHEMBL32096 ZINC29234778 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734743 NCCc1ccc(cc1)S(N)(=O)=O InChI=1S/C8H12N2O2S/c9-6-5-7-1-3-8(4-2-7)13(10,11)12/h1-4H,5-6,9H2,(H2,10,11,12) FXNSVEQMUYPYJS-UHFFFAOYSA-N 10861 4-(2-aminoethyl)benzene-1-sulfonamide::CHEMBL7087::aromatic sulfonamide compound 7::aromatic/heteroaromatic sulfonamide 6 Carbonic anhydrase 4 Homo sapiens 2500 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10861&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ZYX 2NNG 169682 46511433 CHEMBL7087 DB08782 ZINC00056629 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734758 NS(=O)(=O)c1ccc(NNC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)NNc2ccc(cc2)S(N)(=O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C26H37N9O12S2/c27-48(44,45)20-5-1-18(2-6-20)29-31-22(36)13-34(16-25(40)41)11-9-33(15-24(38)39)10-12-35(17-26(42)43)14-23(37)32-30-19-3-7-21(8-4-19)49(28,46)47/h1-8,29-30H,9-17H2,(H,31,36)(H,32,37)(H,38,39)(H,40,41)(H,42,43)(H2,27,44,45)(H2,28,46,47) UNEUBPFDOWMHSM-UHFFFAOYSA-N 50097297 CHEMBL262389::{{2-[Carboxymethyl-(2-{carboxymethyl-[N'-(4-sulfamoyl-phenyl)-hydrazinocarbonylmethyl]-amino}-ethyl)-amino]-ethyl}-[N'-(4-sulfamoyl-phenyl)-hydrazinocarbonylmethyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 430 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097297&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10996222 103994629 CHEMBL262389 ZINC34717933 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734759 NS(=O)(=O)c1ccc(NNC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C20H30N6O11S/c21-38(36,37)15-3-1-14(2-4-15)22-23-16(27)9-25(11-18(30)31)7-5-24(10-17(28)29)6-8-26(12-19(32)33)13-20(34)35/h1-4,22H,5-13H2,(H,23,27)(H,28,29)(H,30,31)(H,32,33)(H,34,35)(H2,21,36,37) VDCQRGADIMUOMM-UHFFFAOYSA-N 50097311 CHEMBL286549::{(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-[N'-(4-sulfamoyl-phenyl)-hydrazinocarbonylmethyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 630 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097311&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11060771 103994643 CHEMBL286549 ZINC29243814 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734764 Nc1c(Cl)c(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O InChI=1S/C6H7Cl2N3O4S2/c7-4-2(16(10,12)13)1-3(17(11,14)15)6(9)5(4)8/h1H,9H2,(H2,10,12,13)(H2,11,14,15) DNBXGTICJYDFDT-UHFFFAOYSA-N 50079043 4-Amino-5,6-dichloro-benzene-1,3-disulfonic acid diamide::4-amino-5,6-dichlorobenzene-1,3-disulfonamide::BDBM50222601::CHEMBL269628 Carbonic anhydrase 4 Homo sapiens 175 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079043&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2781602 103971392 CHEMBL269628 ZINC04073059 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734765 NS(=O)(=O)c1ccc(CCOC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C22H32N4O12S/c23-39(36,37)17-3-1-16(2-4-17)5-10-38-22(35)15-26(14-21(33)34)9-7-24(11-18(27)28)6-8-25(12-19(29)30)13-20(31)32/h1-4H,5-15H2,(H,27,28)(H,29,30)(H,31,32)(H,33,34)(H2,23,36,37) POFVJKOCBGVKKG-UHFFFAOYSA-N 50097312 CHEMBL35043::{(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-[2-(4-sulfamoyl-phenyl)-ethoxycarbonylmethyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 190 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097312&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10897133 103994644 CHEMBL35043 ZINC29248244 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734768 Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O InChI=1S/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14) IHJCXVZDYSXXFT-UHFFFAOYSA-N 10867 4-amino-6-chlorobenzene-1,3-disulfonamide::CHEMBL266240::aromatic/heteroaromatic sulfonamide 12 Carbonic anhydrase 4 Homo sapiens 160 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10867&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search I7B 7NML,2POV,3L14 67136 46511439 CHEMBL266240 C07460 ZINC01530783 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734775 NS(=O)(=O)c1nnc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)s1 InChI=1S/C16H25N7O11S2/c17-36(33,34)16-20-19-15(35-16)18-10(24)5-22(7-12(27)28)3-1-21(6-11(25)26)2-4-23(8-13(29)30)9-14(31)32/h1-9H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)(H2,17,33,34)(H,18,19,24) ZZJKKUWYWYKHBB-UHFFFAOYSA-N 50097300 (Carboxymethyl-{2-[carboxymethyl-(2-{carboxymethyl-[(5-sulfamoyl-[1,3,4]thiadiazol-2-ylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-amino)-acetic acid::CHEMBL32606 Carbonic anhydrase 4 Homo sapiens 28 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097300&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3365615 103994632 CHEMBL32606 ZINC29230564 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734778 NS(=O)(=O)c1ccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)c(Br)c1 InChI=1S/C20H28BrN5O11S/c21-14-7-13(38(22,36)37)1-2-15(14)23-16(27)8-25(10-18(30)31)5-3-24(9-17(28)29)4-6-26(11-19(32)33)12-20(34)35/h1-2,7H,3-6,8-12H2,(H,23,27)(H,28,29)(H,30,31)(H,32,33)(H,34,35)(H2,22,36,37) XWWOZWMZWMFCLV-UHFFFAOYSA-N 50097294 ({2-[(2-{[(2-Bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-carboxymethyl-amino}-ethyl)-carboxymethyl-amino]-ethyl}-carboxymethyl-amino)-acetic acid::CHEMBL34768::{(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-[(2-bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 27 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097294&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10930187 103994626 CHEMBL34768 ZINC29245573 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734781 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 220 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734789 NCCC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C5H9N5O3S2/c6-2-1-3(11)8-4-9-10-5(14-4)15(7,12)13/h1-2,6H2,(H2,7,12,13)(H,8,9,11) HBVCBMSBBJBRRW-UHFFFAOYSA-N 50079068 3-amino-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-propionamide::CHEMBL13646 Carbonic anhydrase 4 Homo sapiens 125 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079068&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10243877 103971417 CHEMBL13646 ZINC03974870 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734790 NS(=O)(=O)c1ccc(NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)Nc2ccc(cc2Br)S(N)(=O)=O)CC(O)=O)CC(O)=O)c(Br)c1 InChI=1S/C26H33Br2N7O12S2/c27-18-9-16(48(29,44)45)1-3-20(18)31-22(36)11-34(14-25(40)41)7-5-33(13-24(38)39)6-8-35(15-26(42)43)12-23(37)32-21-4-2-17(10-19(21)28)49(30,46)47/h1-4,9-10H,5-8,11-15H2,(H,31,36)(H,32,37)(H,38,39)(H,40,41)(H,42,43)(H2,29,44,45)(H2,30,46,47) UHLGJGLIMGHELQ-UHFFFAOYSA-N 50097313 ([(2-Bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-{2-[(2-{[(2-bromo-4-sulfamoyl-phenylcarbamoyl)-methyl]-carboxymethyl-amino}-ethyl)-carboxymethyl-amino]-ethyl}-amino)-acetic acid::CHEMBL287316 Carbonic anhydrase 4 Homo sapiens 21 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097313&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10974944 103994645 CHEMBL287316 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734795 NS(=O)(=O)c1ccccc1NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)Nc1ccccc1S(N)(=O)=O)CC(O)=O)CC(O)=O InChI=1S/C26H35N7O12S2/c27-46(42,43)20-7-3-1-5-18(20)29-22(34)13-32(16-25(38)39)11-9-31(15-24(36)37)10-12-33(17-26(40)41)14-23(35)30-19-6-2-4-8-21(19)47(28,44)45/h1-8H,9-17H2,(H,29,34)(H,30,35)(H,36,37)(H,38,39)(H,40,41)(H2,27,42,43)(H2,28,44,45) CBYCNLHEUYGUFO-UHFFFAOYSA-N 50097299 CHEMBL35528::{{2-[Carboxymethyl-(2-{carboxymethyl-[(2-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(2-sulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 330 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097299&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11828627 103994631 CHEMBL35528 ZINC34717935 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734796 NS(=O)(=O)c1nc2ccc(OCCOC(=O)CN(CCN(CCN(CC(O)=O)CC(O)=O)CC(O)=O)CC(O)=O)cc2s1 InChI=1S/C23H31N5O13S2/c24-43(38,39)23-25-16-2-1-15(9-17(16)42-23)40-7-8-41-22(37)14-28(13-21(35)36)6-4-26(10-18(29)30)3-5-27(11-19(31)32)12-20(33)34/h1-2,9H,3-8,10-14H2,(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H2,24,38,39) LRADDEITIGOBAG-UHFFFAOYSA-N 50097293 CHEMBL34852::{(2-{[2-(Bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-[2-(2-sulfamoyl-benzothiazol-6-yloxy)-ethoxycarbonylmethyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 5 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097293&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10963315 103994625 CHEMBL34852 ZINC29250749 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734797 NS(=O)(=O)c1cc(c(NC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)Nc2c(Cl)c(Cl)c(cc2S(N)(=O)=O)S(N)(=O)=O)CC(O)=O)CC(O)=O)c(Cl)c1Cl)S(N)(=O)=O InChI=1S/C26H33Cl4N9O16S4/c27-21-12(56(31,48)49)5-14(58(33,52)53)25(23(21)29)35-16(40)7-38(10-19(44)45)3-1-37(9-18(42)43)2-4-39(11-20(46)47)8-17(41)36-26-15(59(34,54)55)6-13(57(32,50)51)22(28)24(26)30/h5-6H,1-4,7-11H2,(H,35,40)(H,36,41)(H,42,43)(H,44,45)(H,46,47)(H2,31,48,49)(H2,32,50,51)(H2,33,52,53)(H2,34,54,55) OOLIXLGXVWZENE-UHFFFAOYSA-N 50097290 CHEMBL32208::{{2-[Carboxymethyl-(2-{carboxymethyl-[(2,3-dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-ethyl)-amino]-ethyl}-[(2,3-dichloro-4,6-disulfamoyl-phenylcarbamoyl)-methyl]-amino}-acetic acid Carbonic anhydrase 4 Homo sapiens 25 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097290&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10920174 103994622 CHEMBL32208 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50734798 NS(=O)(=O)c1ccc(COC(=O)CN(CCN(CCN(CC(O)=O)CC(=O)OCc2ccc(cc2)S(N)(=O)=O)CC(O)=O)CC(O)=O)cc1 InChI=1S/C28H37N5O14S2/c29-48(42,43)22-5-1-20(2-6-22)18-46-27(40)16-32(14-25(36)37)11-9-31(13-24(34)35)10-12-33(15-26(38)39)17-28(41)47-19-21-3-7-23(8-4-21)49(30,44)45/h1-8H,9-19H2,(H,34,35)(H,36,37)(H,38,39)(H2,29,42,43)(H2,30,44,45) OCBZPIHVMSMCBT-UHFFFAOYSA-N 50097286 CHEMBL408857::[[2-(Carboxymethyl-{2-[carboxymethyl-(4-sulfamoyl-benzyloxycarbonylmethyl)-amino]-ethyl}-amino)-ethyl]-(4-sulfamoyl-benzyloxycarbonylmethyl)-amino]-acetic acid Carbonic anhydrase 4 Homo sapiens 170 ChEMBL 10.1016/s0960-894x(00)00722-8 10.7270/Q2KW5GJQ 11229775 Scozzafava, A; Menabuoni, L; Mincione, F; Mincione, G; Supuran, CT Universit£ degli Studi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097286&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11967046 103994618 CHEMBL408857 ZINC34717931 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825134 CCOc1ccc2nc(sc2c1)S(N)(=O)=O InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) OUZWUKMCLIBBOG-UHFFFAOYSA-N 10882 6-ethoxy-1,3-benzothiazole-2-sulfonamide::CHEMBL18::Ethamide::Ethoxazolamide::Ethoxzolamide::Ethoxzolamide (EZA)::Ethoxzolamide, EZM::Sulfonamide, 3::US10172837, Ethoxyzolamide::sulfonamide 3 Carbonic anhydrase 4 Homo sapiens 93 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10882&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EZL 3DD0,5JN9,3CAJ,3MDZ,6BCC,3DCW,6QL2,5TT3,6MWI 3295 46511452 101096 CHEMBL18 DB00311 6814 ZINC00056721 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825140 Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O InChI=1S/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14) IHJCXVZDYSXXFT-UHFFFAOYSA-N 10867 4-amino-6-chlorobenzene-1,3-disulfonamide::CHEMBL266240::aromatic/heteroaromatic sulfonamide 12 Carbonic anhydrase 4 Homo sapiens 380 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10867&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search I7B 7NML,2POV,3L14 67136 46511439 CHEMBL266240 C07460 ZINC01530783 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825144 Nc1ccc(cc1Cl)S(N)(=O)=O InChI=1S/C6H7ClN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11) LFIOFZKZCDMGFG-UHFFFAOYSA-N 10863 4-Amino-3-chlorobenzenesulfonamide::4-amino-3-chlorobenzene-1-sulfonamide::CHEMBL7092::aromatic/heteroaromatic sulfonamide 8::halogenosulfanilamide deriv. 5c Carbonic anhydrase 4 Homo sapiens 450 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10863&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1502014 46511435 CHEMBL7092 ZINC01420707 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825146 Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) RZEKVGVHFLEQIL-UHFFFAOYSA-N 11639 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide::CHEMBL118::CLX::Celebrex::Celecoxib::US10322118, Urea-Based Scaffold Entry 9::US11478464, Compound Celecoxib::US8741944, Comparative Compound::US9388139, Celecoxib::cid_2662 Carbonic anhydrase 4 Homo sapiens 880 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11639&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CEL 3LN1,3KK6,5JW1,7ZEJ,4FIM,1OQ5 2662 46512162 41423 CHEMBL118 DB00482 2892 C07589 ZINC02570895 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825148 Nc1cc(c(cc1S(N)(=O)=O)S(N)(=O)=O)C(F)(F)F InChI=1S/C7H8F3N3O4S2/c8-7(9,10)3-1-4(11)6(19(13,16)17)2-5(3)18(12,14)15/h1-2H,11H2,(H2,12,14,15)(H2,13,16,17) KRVABEGPNKGLOT-UHFFFAOYSA-N 10866 4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide::CHEMBL418::aromatic/heteroaromatic sulfonamide 11 Carbonic anhydrase 4 Homo sapiens 4830 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10866&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search I7C 2POW 69561 46511438 CHEMBL418 ZINC01676919 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825149 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 IAVUPMFITXYVAF-XPUUQOCRSA-N 10884 (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide::Dorzolamide (DRZ)::Dorzolamide (DZA) Carbonic anhydrase 4 Homo sapiens 8530 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10884&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ETS 4M2W,4M2U,4K13,3FW3,6BC9,1CIL 5284549 46511454 4702 DB00869 6810 C06969 ZINC01530621 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825151 CC(=O)N=c1sc(nn1C)S(N)(=O)=O InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) FLOSMHQXBMRNHR-UHFFFAOYSA-N 10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid_4100::sulfonamide 2 Carbonic anhydrase 4 Homo sapiens 6200 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10881&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search MZM 4K0Z,4YHA,5KU6,1BZM,5C8I,3DAZ,3DCS 4100 46511451 CHEMBL288100 6828 ZINC12503151 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825155 Nc1ccc(cc1Br)S(N)(=O)=O InChI=1S/C6H7BrN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11) KQEVQYJWCZRLTJ-UHFFFAOYSA-N 10864 4-Amino-3-bromobenzenesulfonamide::4-amino-3-bromobenzene-1-sulfonamide::CHEMBL6724::aromatic/heteroaromatic sulfonamide 9::halogenosulfanilamide deriv. 5d Carbonic anhydrase 4 Homo sapiens 96 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10864&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3526523 46511436 CHEMBL6724 ZINC12522340 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825156 Nc1ccc(cc1)S(=O)(=O)NCc1ccc(cc1)S(N)(=O)=O InChI=1S/C13H15N3O4S2/c14-11-3-7-13(8-4-11)22(19,20)16-9-10-1-5-12(6-2-10)21(15,17)18/h1-8,16H,9,14H2,(H2,15,17,18) HHCXOFYGBAPOJR-UHFFFAOYSA-N 10871 4-amino-N-[(4-sulfamoylphenyl)methyl]benzene-1-sulfonamide::CHEMBL266026::aromatic/heteroaromatic sulfonamide 16 Carbonic anhydrase 4 Homo sapiens 84 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10871&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4422372 46511442 CHEMBL266026 ZINC06392199 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825157 Nc1cccc(c1)S(N)(=O)=O InChI=1S/C6H8N2O2S/c7-5-2-1-3-6(4-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) JPVKCHIPRSQDKL-UHFFFAOYSA-N 50079047 3-Amino-benzenesulfonamide::3-aminobenzenesulfonamide::CHEMBL6852 Carbonic anhydrase 4 Homo sapiens 7750 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079047&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7377 103971396 CHEMBL6852 ZINC03874012 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825159 CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 KJADKKWYZYXHBB-XBWDGYHZSA-N 10887 Sulfamate 7::Topiramate (TPM)::US11535599, Example topiramate::[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate Carbonic anhydrase 4 Homo sapiens 4900 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10887&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TOR 3LXE,3HKU,5JNA 5284627 46511457 63631 DB00273 6849 C07502 ZINC01530804 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825165 NCc1ccc(cc1)S(N)(=O)=O InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11) TYMRLRRVMHJFTF-UHFFFAOYSA-N 10860 4-(aminomethyl)benzene-1-sulfonamide::CHEMBL419::MAFENIDE::aromatic sulfonamide compound 6::aromatic/heteroaromatic sulfonamide 5::hCA inhibitor, 9 Carbonic anhydrase 4 Homo sapiens 8600 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10860&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 6LH 5JNC 3998 46511432 CHEMBL419 DB06795 C07106 ZINC00001644 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825166 NCCc1ccc(cc1)S(N)(=O)=O InChI=1S/C8H12N2O2S/c9-6-5-7-1-3-8(4-2-7)13(10,11)12/h1-4H,5-6,9H2,(H2,10,11,12) FXNSVEQMUYPYJS-UHFFFAOYSA-N 10861 4-(2-aminoethyl)benzene-1-sulfonamide::CHEMBL7087::aromatic sulfonamide compound 7::aromatic/heteroaromatic sulfonamide 6 Carbonic anhydrase 4 Homo sapiens 3570 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10861&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ZYX 2NNG 169682 46511433 CHEMBL7087 DB08782 ZINC00056629 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825179 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825182 Nc1nnc(s1)S(N)(=O)=O InChI=1S/C2H4N4O2S2/c3-1-5-6-2(9-1)10(4,7)8/h(H2,3,5)(H2,4,7,8) VGMVBPQOACUDRU-UHFFFAOYSA-N 10868 1,3,4-Thiadiazole-2-sulfonamide, 6::1,3,4-thiadiazole-2-sulfonamide 15::5-Amino-1,3,4-thiadiazole-2-sulphonamide (1)::5-amino-1,3,4-thiadiazole-2-sulfonamide::CHEMBL265674::aromatic/heteroaromatic sulfonamide 13 Carbonic anhydrase 4 Homo sapiens 940 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10868&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1SA 2HNC,5TUO 84724 46509349 CHEMBL265674 ZINC16969869 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825190 Nc1ccc(cc1F)S(N)(=O)=O InChI=1S/C6H7FN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11) HVFBADWBKHAPKV-UHFFFAOYSA-N 10862 4-Amino-3-fluorobenzenesulfonamide::4-amino-3-fluorobenzene-1-sulfonamide::CHEMBL6853::aromatic/heteroaromatic sulfonamide 7::halogenosulfanilamide deriv. 5b Carbonic anhydrase 4 Homo sapiens 910 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10862&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4687472 46511434 CHEMBL6853 ZINC06925827 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825191 Nc1ccc(cc1I)S(N)(=O)=O InChI=1S/C6H7IN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11) HCODCRHNVCTCTR-UHFFFAOYSA-N 10865 4-Amino-3-iodobenzenesulfonamide::4-amino-3-iodobenzene-1-sulfonamide::CHEMBL268177::aromatic/heteroaromatic sulfonamide 10::halogenosulfanilamide deriv. 5e Carbonic anhydrase 4 Homo sapiens 920 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10865&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 9861037 46511437 CHEMBL268177 ZINC13442499 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825204 Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) FDDDEECHVMSUSB-UHFFFAOYSA-N 10857 4-aminobenzene-1-sulfonamide::CHEMBL21::Sulfanilamide::aromatic sulfonamide compound 5::aromatic/heteroaromatic sulfonamide 2::halogenosulfanilamide deriv. 5a Carbonic anhydrase 4 Homo sapiens 9760 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10857&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SAN 8BCB,1AJ0,4F93,4F92,4COQ,6RL9 5333 46511429 45373 CHEMBL21 DB00259 C07458 ZINC00002101 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825207 NNc1ccc(cc1)S(N)(=O)=O InChI=1S/C6H9N3O2S/c7-9-5-1-3-6(4-2-5)12(8,10)11/h1-4,9H,7H2,(H2,8,10,11) NBJSNAGTUCWQRO-UHFFFAOYSA-N 10858 4-hydrazinylbenzene-1-sulfonamide::CHEMBL7204::aromatic/heteroaromatic sulfonamide 3::hydrazide deriv. 14 Carbonic anhydrase 4 Homo sapiens 7700 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10858&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 78105 46511430 CHEMBL7204 ZINC00152965 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825210 NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) GJQPMPFPNINLKP-UHFFFAOYSA-N 10883 4,5-dichlorobenzene-1,3-disulfonamide::CHEMBL17::Dichlorophenamide::Dichlorophenamide (DCP)::Dichlorophenamide, DCP::Sulfonamide, 4::US10172837, Dichlorphenamide::sulfonamide 4 Carbonic anhydrase 4 Homo sapiens 15330 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10883&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search I7A 2POU 3038 46511453 101085 CHEMBL17 DB01144 6807 C07459 ZINC00896918 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50825171 Cc1onc(c1-c1ccc(cc1)S(N)(=O)=O)-c1ccccc1 InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20) LNPDTQAFDNKSHK-UHFFFAOYSA-N 13063 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonamide::Bextra::CHEMBL865::VLX::Valdecoxib::cid_119607 Carbonic anhydrase 4 Homo sapiens 1340 ChEMBL 10.1016/j.bmcl.2004.12.009 10.7270/Q2JS9R6Q 15686931 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13063&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search COX 2AW1 119607 46513481 63634 CHEMBL865 DB00580 2894 ZINC00006694 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50822999 O[N+]([O-])=O InChI=1S/HNO3/c2-1(3)4/h(H,2,3,4) GRYLNZFGIOXLOG-UHFFFAOYSA-N 50152970 CHEMBL1352::HONO2::nitric acid Carbonic anhydrase 4 Homo sapiens 58700000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50152970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50152970&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 944 104040972 29794 CHEMBL1352 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823002 [N-]=C=S InChI=1S/CNS/c2-1-3/q-1 ZBKFYXZXZJPWNQ-UHFFFAOYSA-N 26983 CHEMBL1644028::SCN(-1)::Thiocyanate::cyanosulfanide::sodium thiocyanate Carbonic anhydrase 4 Homo sapiens 39000000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26983&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SCN 3B3C,3B3S,3B3V,3B3W,3B3T,3B35,1YLK,3GCL,3GCK,3GCJ,3GC1,4IMQ,4IMZ,4IMO,4YGK,1DNU,1DNW,5HNS,6QJU,5LIH,3VRK,6THV,2YOA,6JPT,2TCI,6LCO,3CQX,1KGS,6L9T,4RJD,2EHA,3ERA,3ERH,3ERI,5LE2,6KV0,3R15,4NPE,5JQ4,3CGM,2OLZ,6BTP,6BTQ,6BTO,6KY7,6YJI,3N8F,4NYW,2FA2,7QKN,4L82,3TGY,3ZXN,7U4I,7U4J,1GXW,2YAS,3N72,6D9N,2VR6,2VR7,2VR8,5QJ0,4A9K,2YLC,3QZ0,5VP3,2F49,4GV5,3BFF,3VH9,2EB5,2EB4,6D2J,6D2V,6DXX,5OLG,4JPS,3MNP,2WWP,3R5O,3R55,7Q4A,6EOL,6EOG,7Z0N,2PA5,1UTH,3S4F,7TOM,6H1F,4Z9S,5GLS,3TL2,6X94,2OM1,6BSL,4GM7,4WND,5N4I,1Y81,4ETQ,6A6Y,7B9C,7DE5,5OVV,3WAW,2UYE,2UYF,8BB2,8BB3,8BB5,4EB0,3GA5,6MAN,6GS3,2AV1,3CIX,6X8O,4MSF,2PUM,7O21,6YHQ,5OUF,2Y27,2RFL,3HUF,6XOC,6EVB,6EV8,6EV5,3O5O,3BXI,3BXH,4OD7,4R0Q,4NPD,4AUP,4V0C,4ZG6,4ZGA,6W35,5U28,7OIH,4KSZ,7RMS,4A6U,3UCM,7OQ6,2XES,5MZG,5KO0,7P4O,3BOS,5D3D,7TIA,7TIZ,5I83,4PDY,2A9V,5LSY,5LSR,5LSS,2PCU,2ABB,5OBW,5OBU,3Q85,6Y2H,4OEK,6A4Y,3HK0,3U65,7RMR,5HBB,6NWL,4UE0,4E7U,3NKN,3NKO,3NKM,3NKR,3NKP,3NKQ,5I86,6SSS,5EG8,6DU7,4A75,3UBA,7Z3L,7Z3K,1LCN,4HON,6EBX,6EBZ,4UMO,6CCF,3EVX,5YII,5MVV,2H11,5NHT,7ASZ,4FGE,4FGD,3LNY,5LT7,3DSO,3SXV,2A5V,3V6Q,7YZ8,6Y9C,3O71,5FYP,6ZJ7,6ZJ4,6FHN,2QRB,6J9J,1XPP,6RQX,7PB6,6E5B,5M7M,6MR1,1RTQ,5IJQ,2XR9,4ZAY,4ZAX,4ZAZ,4ZAW,4ZAV,4ZAL,4ZAN,4ZAG,4ZAF,5EUX,1TEW,4Y55,3FKJ,5JJY,6QZY,6LF7,5OHY,5OHS,5W53,3SE2,7VLJ,3C70,4XG1,3QF1,1LOK,7ARP,4AB1,3QK2,1SQ4,7QF6,4YB5,2RKY,7YYJ,4L37,2VXH,1BHC,2E9E,2CA2,4OCF,6WU5,4P0C,8ING,5O1X,5A13,7R58,6NUB,6NU5,5E2G,6TF7,6KFB,2WYK,6XPH,7BR1,3PVZ,3R4X,4Y7P,5W4M,2GJM,2WL1,6HAV,6HAE,2OGB,3ETW,3PY4,5K9H,2J51,6LDQ,6XFU,3B7I,4VHB,4QJQ,6U9L,1SP3,3FAQ,6R0K,2FNO,6RZJ,6RZI,6RZL,3V48,2IPS,1XQ9,3H8D,2QPK,3WAY,3WAX,4F36,7AHB,3LNX,6XSN,7OMY,7OMX,7OMZ,7OMW,7OMV,7OMF,5ULH,5LT6,4PCG,6P1E,2JLP,6L2J,7MSQ,6S0F,3IBD,7JTO,5LSZ,5LS7,7L8L,7L8R,6SJ9,2QQT,3FCL,3FCI,3FCF,7S7R,2EFB,7Q63,3I6N,2V51,4D7Z,1U4H,6VDB,5DLW,5DLV,5DLT,5DLB,6LK1,3NOF,3FNL,7ANU,4FUM,4FUO,4FUN,6B8W,5EBE,1LG6,6ZW1,5AE4,6SP8,6SP5,5V8G,3LY5,5TJ7,3KXL,3P1C,3P1D,3P1E,4CRZ,3H79,6XHT,6XHR,6XHS,7AWE,5FA2,7QL7,3BFE,2FAM,1H51,5NRK,6D1P,3EGR,7P0K,4F7O,7ZQX,5AQA,6TC2,7WYJ,4EFR,4EFQ,4EFP,3G5O,4HEI,7XXK,2JFL,7OO2,5ZGS,5M0D,5M0E,5M0M,3UEN,6M7E,5M0S,4PAB,4PAW,6FIE,5AQ8,7OXV,7KOV,1GMK,4CS0,1SXS,2GX9,3SRX,3VEH,1Y7H,3ZZO,6Y9D,4DO8,6I4K,6I4J,6I4I,6I4M,6I4L,6I4G,6I4E,6I4D,3KXI,6ZN1,4TSQ,3POX,3POQ,7PGE,2V3U,5MHP,2WUF,2WUG,2WUD,2WUE,3WAV,2JIL,4TXO,6B6U,6DS9,5K0P,6KUM,3I3N,7P4J,6FHC,3TJQ,5BU6,5BUO,5BUW,5BUX,2OCS,4KAF,2O9S,5LKA,3MNO,3P31,2UV2,5JLB 9322 57298693 48819 CHEMBL1644028 4529 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823006 C#N InChI=1S/CHN/c1-2/h1H LELOWRISYMNNSU-UHFFFAOYSA-N 50152968 Blausaeure::CHEMBL183419::Cyanwasserstoff::[CHN]::formonitrile::hydridonitridocarbonhydrogen(nitridocarbonate)methanenitrile::hydrocyanic acid::hydrogen cyanide Carbonic anhydrase 4 Homo sapiens 770000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50152968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50152968&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 768 104040971 18407 CHEMBL183419 C01326 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823007 O[As](O)(=O)c1ccccc1 InChI=1S/C6H7AsO3/c8-7(9,10)6-4-2-1-3-5-6/h1-5H,(H2,8,9,10) LVKZSFMYNWRPJX-UHFFFAOYSA-N 26997 CHEMBL364571::PhAsO3H2::benzenarsonic acid::benzenearsonic acid::phenylarsonic acid Carbonic anhydrase 4 Homo sapiens 870 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26997&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7365 57298707 29851 CHEMBL364571 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823009 NS(O)(=O)=O InChI=1S/H3NO3S/c1-5(2,3)4/h(H3,1,2,3,4) IIACRCGMVDHOTQ-UHFFFAOYSA-N 26994 CHEMBL68253::H2NSO3H::sulfamic acid Carbonic anhydrase 4 Homo sapiens 930 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26994&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5987 57298704 48266 CHEMBL68253 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823014 [I-] InChI=1S/HI/h1H/p-1 XMBWDFGMSWQBCA-UHFFFAOYSA-M 26981 CHEMBL1644695::I-::POTASSIUM IODIDE::iodide::iodide ion Carbonic anhydrase 4 Homo sapiens 80000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26981&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IDO 1ARX,1ARY,1B2K,1CMK,1CQW,1F09,1F3M,1GW9,1GWA,1GWD,1GWG,1GZA,1HC0,1HC9,1HUH,1J2J,1J99,1JWG,1LKR,1MOU,1MOV,1MXI,1N5M,1NJK,1NZB,1OJ5,1OUQ,1OVL,1OXS,1OXU,1OXV,1OXX,1PVH,1Q0T,1Q3U,1Q3V,1Q8C,1QI9,1QK0,1RLJ,1RRK,1RS0,1RTK,1S1M,1S6V,1SD5,1T1F,1T6C,1TUK,1U12,1U65,1UJK,1UTX,1V1F,1V1G,1VAT,1VKC,1VKO,1W2Z,1W50,1W51,1WC7,1WCB,1WCV,1WNW,1WY4,1XB7,1XC6,1XP4,1Y0S,1YDO,1YKU,1YRI,1ZCR,1ZVV,2A0N,2AF6,2AK4,2ANV,2ANX,2AQW,2ARL,2B9X,2BIV,2BMK,2C3N,2C3Q,2C3V,2CIW,2CJ6,2CJ7,2CJ8,2CKK,2CKL,2D8O,2D8P,2D8W,2D91,2D98,2DFB,2DFC,2DGM,2EDA,2EDC,2EIX,2ES4,2ESV,2EWJ,2FDS,2FWE,2FWF,2FWH,2GGQ,2GJM,2GQ2,2GS7,2GZB,2H9A,2HA0,2HA7,2HIB,2HQ6,2HRA,2I05,2I06,2I1W,2I8E,2ID1,2IPS,2IWK,2IZD,2IZQ,2J7P,2JJS,2NOO,2NQX,2O2B,2O86,2OF0,2OGS,2OGT,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2OJV,2OYY,2P4M,2PFI,2PUM,2Q2L,2QC5,2QCH,2QHX,2QPK,2QQT,2R5L,2REZ,2V8I,2VA5,2VA6,2VA7,2VBV,2VGZ,2VMA,2VUW,2YV7,2Z5Z,3BAS,3BCA,3BS9,3BV9,3CGP,3CJQ,3CT9,3D11,3DHX,3DY6,3E3T,3E7A,3EGV,3F6Q,3FNL 30165 57298691 64428 CHEMBL185537CHEMBL1644695 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823017 [F-] InChI=1S/FH/h1H/p-1 KRHYYFGTRYWZRS-UHFFFAOYSA-M 26978 BDBM50098540::CHEMBL1528::CHEMBL1644027::F-::fluoride::fluoride ion Carbonic anhydrase 4 Homo sapiens 70000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26978&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search F 6WO7,5EVC,6WOA,3MBA,6WO8,2WVG,4KKL,4KK8,7TN4,2XMC,2Q9P,6QDY,6YTT,3VRS,4F60,7KK8,6JIM,1E6A,1LH5,6RI8,6RI6,6RI4,6RIL,6RIK,6RII,1BS3,7T0Y,5NAI,6EVH,5A43,6VCM,6VCL,6LL8,6B2B,6B2A,6B2D,6B24,6BQO,5VEJ,2QFP,5KBN,2LH5,5KOM,3HQ2,6WOB,7TJ1,7F9V,2WSL,2AUU,2AU6,2AU9,6A24,4X30,4ENC,4ENB,4ENA,5K91,1T5G,6BX4,6BX5,6VCK,2AKZ,5NKQ,7KKB,7KKA,3PPM,5XB2,3SSV,4CEX,1NEL,2UVN,2HAW,5XD5,4JB4,4X00,6HOO,2DQZ,4Q3K,6D0J,6D0K,6D0N,7SP3,4KJQ,6WOI,4EN5,4GOA,2Z5Z 28179 57298688 64428 CHEMBL1644027CHEMBL1528CHEMBL1362 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823028 OC([O-])=O InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1 BVKZGUZCCUSVTD-UHFFFAOYSA-M 26986 CHEMBL363707::HCO3-::SODIUM BICARBONATE::bicarbonate ion::hydrogen carbonate Carbonic anhydrase 4 Homo sapiens 6600000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26986&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BCT 3E2W,3V83,7R30,2JF9,2ILM,6YW0,6YW1,4ZJY,4IXQ,4IXR,4IXZ,4URF,2HC9,7PHO,4V82,3RV4,5B5E,7ADY,3G8C,4YRW,1ZTJ,3Q6J,5LHK,6OAD,7ZB0,7RF1,1HCB,6ABU,6VCF,6W1O,6W1V,6W1T,6W1R,6W1P,6W1Q,3HCN,3HCO,4WAK,6KAC,6KAF,6KAD,7PIN,7PIW,7PI5,7PI0,6KLZ,3U7C,7EVQ,5MX2,5B66,5LBC,2PIJ,4YSW,4Z9V,4FBY,7JRD,4LHD,5DRK,7RP9,7RPC,7RPB,7RPA,7RPF,7RPE,7RPD,5N4I,6WQP,4C7Z,4C7Y,1F9B,8GVC,6I33,6I35,6AC1,3OW5,6KM2,7ZAZ,7EGL,1S5L,4YTY,4YTZ,2A8D,7N8O,5ZJW,5TG6,5TG7,5TG4,5TG5,5OUF,6LV1,6LV2,6LV4,6LV6,6LV8,4PJ0,1YQW,3GLR,6A7X,5BXI,4DKI,4RY9,5NTD,5NTH,4H83,4WHQ,4WHP,4WHO,7YQ2,7YQ7,7ZZ3,7ZZ5,7EQU,3V7P,1OAO,2IST,2AXT,4K0X,4K0W,7COU,2BGS,4YUU,7RCV,3OU9,1VRG,7WK7,6G55,7N88,5D4O,5D4P,5O3Q,5O3R,3WDR,5HBC,3H02,5CRY,6DUX,1LI0,4ELS,1ZML,5ZAS,7OUI,5LAT,5TIS,4US8,4US9,4USA,2J7Y,2J7X,7ADR,6KM0,6KM1,8EZ5,3SXM,3SXK,4RVY,4RVA,5KAF,5KAI,6N7F,7A24,7A23,4ZLA,1CAM,1CAH,6YP7,7KCT,8EQM,8F4J,8F4K,8F4H,8F4I,8F4F,8F4G,8F4D,8F4C,4XZ5,3VBI,3VBK,3VBM,3VBL,4EML,7D1P,7D1T,7D1U,7D1N,6SC3,7KBL,4KLR,7EDA,4LHC,3DTB,2QD2,4YBO,7Y7A,6DIK,7ZB1,6F89,2FDA,7PNK,6SC0,4I4Z,4I42,7ZYY,6KI1,5V2C,5DEI,7D2J,4CLL,5WS5,5WS6,5GTI,3AN1,6DHH,6DHO,6DHF,6DHG,6DHE,6DHP,1V67,3H8G,3H8F,4C80,3WAE,1DXK,2ESF,3AX7,3AX9,4Z7J,1ZSJ,1ZSK,6W1U,1CL1,7O9N,6MYP,6J40,3AM9,3AMZ,7Y5E,2D3I,2VVB,4ZI6,6SJ0,7AIZ,7PE4,6UJ6,6XR0,7VD5,5ZZN,7C5V,7C5X,1LGD,2E3T,4PBU,7NHO,4MV9,4MV3,1BVT,7CJI,7CJJ,3WU2,2E1Q,6J3Y,6J3Z,4Q2H,6WJ6,6IM0,5CXK,7RF8,7RF5,7RF4,7RF7,7RF6,7RF3,7RF2,1BIC,5E79,5E7C,4A1T,6AJU,4UB8,4UB6,4V62,8EPZ,1JF8,1QRL,1QRE,4DUR,5ADT,5ADR,5ADS,5ADQ,6SQX,3E3F,3E3I,3VM1,4QRO,5LBE,5LBF,5LBB,3JCU,5FBK,5FBH,6JLP,6JLU,6JLJ,6JLK,6JLL,6JLM,6JLN,6JLO,4X53,4TNJ,4TNK,4TNH,4TNI,5XNM,6AD4,6YVX,6YVZ,5GTH,4RFD,5NSM,5NSP,2I4C,2I4B,4EGS,4IT1,8F4E,4OYZ,2C1L,5H2F,1MZ4,3E2A,3KZI,5OX5,4IL6,7CZL,5XNL 769 57298696 28976 CHEMBL363707 DB01390 C00288 ZINC06827693 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823029 [SH-] InChI=1S/H2S/h1H2/p-1 RWSOTUBLDIXVET-UHFFFAOYSA-M 26990 CHEMBL1644699::HS anion::HS(-1)::hydrogen(sulfide)(-1)::hydrosulfide::sulfanide Carbonic anhydrase 4 Homo sapiens 3900000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26990&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search S 5047209 57298700 16136 CHEMBL38703CHEMBL1644699 C00283 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823032 [Cl-] InChI=1S/ClH/h1H/p-1 VEXZGXHMUGYJMC-UHFFFAOYSA-M 26979 CHEMBL69710::Cl-::POTASSIUM CHLORIDE::SODIUM CHLORIDE::chloride::chloride ion Carbonic anhydrase 4 Homo sapiens 90000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26979&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CL 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312 57298689 64428 CHEMBL19429CHEMBL69710 2339 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823035 NS(N)(=O)=O InChI=1S/H4N2O2S/c1-5(2,3)4/h(H4,1,2,3,4) NVBFHJWHLNUMCV-UHFFFAOYSA-N 26995 CHEMBL355001::H2NSO2NH2::sulfamamide::sulfamide::sulfamoylamine Carbonic anhydrase 4 Homo sapiens 880 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26995&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search FUS 6D2N 82267 57298705 48266 CHEMBL355001 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823046 [O-]S([O-])(=O)=O InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 QAOWNCQODCNURD-UHFFFAOYSA-L 26992 CHEMBL183495::SO4(2-)::SODIUM SULFATE::sulfate::sulfate ion Carbonic anhydrase 4 Homo sapiens 9000000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26992&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SO4 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1117 57298702 29922 CHEMBL183495 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823048 [N-]=C=O InChI=1S/CNO/c2-1-3/q-1 IQPQWNKOIGAROB-UHFFFAOYSA-N 26982 CHEMBL1644696::CNO(-1)::cyanate Carbonic anhydrase 4 Homo sapiens 610000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26982&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 105034 57298692 48819 CHEMBL1644696 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823062 [Br-] InChI=1S/BrH/h1H/p-1 CPELXLSAUQHCOX-UHFFFAOYSA-M 26980 Br-::CHEMBL1644030::CHEMBL1644694::bromide::bromide ion Carbonic anhydrase 4 Homo sapiens 90000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26980&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BR 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259 57298690 64428 CHEMBL11685CHEMBL1644030CHEMBL1644694 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823064 OS([O-])=O InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 LSNNMFCWUKXFEE-UHFFFAOYSA-M 26991 CHEMBL1689285::HSO3-::bisulfite::hydrogen sulfite Carbonic anhydrase 4 Homo sapiens 13200000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26991&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1DD7,1EAF,1FT6,1I9D,1J3M,1JNZ,1JZW,1K0I,1K0L,1LTD,1NRS,1OKG,1R8S,1TLL,1URH,1VYB,1WMG,1YT8,2C3J,2CBD,2D2X,2E1D,2GAG,2GEP,2GRU,2HCI,2HZ1,2ORO,2PCJ,2V3P,2V4J,2VQ2,2VVH,2VVI,2VVJ,3BNF,3BNJ,3C7B,3F29,5CAC 104748 57298701 17137 CHEMBL1689285 C01615 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823065 N=[N+]=[N-] InChI=1S/HN3/c1-3-2/h1H JUINSXZKUKVTMD-UHFFFAOYSA-N 50153977 CHEMBL186537::N3H::[NNNH]::hydrazoic acid::hydrido-1kappaH-trinitrogen(2N--N)hydrogen trinitride(1-)::hydrogen azide::triazoic acid Carbonic anhydrase 4 Homo sapiens 65100000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153977&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 24530 104041728 36825 CHEMBL186537 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823068 OB(O)c1ccccc1 InChI=1S/C6H7BO2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9H HXITXNWTGFUOAU-UHFFFAOYSA-N 26996 CHEMBL21485::PhB(OH)2::Phenyl-boronic acid::Phenylboronic acid, 22::benzeneboronic acid::phenylboranediol::phenylboronic acid Carbonic anhydrase 4 Homo sapiens 880 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26996&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PBC 6VIM,1JU3,6UQU,4OB0,2A32 66827 57298706 44923 CHEMBL21485 DB01795 C16200 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823078 [O-]N=O InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1 IOVCWXUNBOPUCH-UHFFFAOYSA-M 26989 CHEMBL93268::NO2-::nitrite::nitrite ion Carbonic anhydrase 4 Homo sapiens 30800000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26989&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search NO2 1WA2,2XWZ,1J9T,2DWT,2DWS,2XX1,5VZO,5VZN,5VZQ,5VZP,5OG5,5D4I,5D4H,1FDI,5AKR,5NGX,3V2Z,3V2V,7ZCR,7ZCS,7ZCP,7ZCQ,7ZCN,7ZCO,3VKP,3TGC,1SJM,5HLX,3X1N,5F7A,3MM9,2FRF,2FRI,3BNH,6QQ2,3S7W,3RKH,3OO5,3OO4,1AS8,1AS6,4CSZ,5TR7,3D1I,6GT0,6GTL,6GTN,6GTI,6GTK,6FL2,3OUO,5OBO,5HWZ,3ONZ,4JRE,2XZI,2QMK,3VKR,3VKQ,7OU5,7OU7,7OU9,7OUY,5Z7E,5Z7F,5UT9,5UT7,3MLK,5UTA,5UTD,3GEO,5NC0,2E80,4N8T,6QWG,3OWM,4M4U,4L3Y,4L3X,4L3Z,4L38,8ING,3HEO,3HEP,6NU9,6TFD,3WKP,5OGG,5OGF,5OG3,5OG4,5OG6,5ZCY,6PDV,3OV9,3Q09,6GB8,6GBY,5OG2,5OFF,5OFG,5OFC,5OFH,5OF6,5OF7,5OF5,5OF8,4G1V,1NID,1NDS,2PPC,4I6Y,3VAU,3Q08,1J9R,1J9S,1J9Q,3LR7,3LR9,2YBI,2YBJ,2YBN,2BWD,2BWI,6ZAX,6ZAU,6ZAT,6GBB,2QV4,7WYJ,3MIB,3MIG,2O5S,2O5O,3MVF,3VM0,1L9O,1L9P,1L9Q,1L9R,1L9S,1L9T,3D7O,5I6P,5I6K,5I6L,5I6M,5I6N,2YBL,1KBV,6QPX,6QPT,2JIR,2JIQ,6CF0,6ZU6,6ZUB,6ZUA,6ZUD,5AG1,6QQ0 946 57298699 16301 CHEMBL93268 DB09112 C00088 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50823084 OC([O-])=O InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1 BVKZGUZCCUSVTD-UHFFFAOYSA-M 26986 CHEMBL363707::HCO3-::SODIUM BICARBONATE::bicarbonate ion::hydrogen carbonate Carbonic anhydrase 4 Homo sapiens 6600000 ChEMBL 10.1016/j.bmcl.2004.09.063 10.7270/Q24X58JJ 15501038 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26986&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BCT 3E2W,3V83,7R30,2JF9,2ILM,6YW0,6YW1,4ZJY,4IXQ,4IXR,4IXZ,4URF,2HC9,7PHO,4V82,3RV4,5B5E,7ADY,3G8C,4YRW,1ZTJ,3Q6J,5LHK,6OAD,7ZB0,7RF1,1HCB,6ABU,6VCF,6W1O,6W1V,6W1T,6W1R,6W1P,6W1Q,3HCN,3HCO,4WAK,6KAC,6KAF,6KAD,7PIN,7PIW,7PI5,7PI0,6KLZ,3U7C,7EVQ,5MX2,5B66,5LBC,2PIJ,4YSW,4Z9V,4FBY,7JRD,4LHD,5DRK,7RP9,7RPC,7RPB,7RPA,7RPF,7RPE,7RPD,5N4I,6WQP,4C7Z,4C7Y,1F9B,8GVC,6I33,6I35,6AC1,3OW5,6KM2,7ZAZ,7EGL,1S5L,4YTY,4YTZ,2A8D,7N8O,5ZJW,5TG6,5TG7,5TG4,5TG5,5OUF,6LV1,6LV2,6LV4,6LV6,6LV8,4PJ0,1YQW,3GLR,6A7X,5BXI,4DKI,4RY9,5NTD,5NTH,4H83,4WHQ,4WHP,4WHO,7YQ2,7YQ7,7ZZ3,7ZZ5,7EQU,3V7P,1OAO,2IST,2AXT,4K0X,4K0W,7COU,2BGS,4YUU,7RCV,3OU9,1VRG,7WK7,6G55,7N88,5D4O,5D4P,5O3Q,5O3R,3WDR,5HBC,3H02,5CRY,6DUX,1LI0,4ELS,1ZML,5ZAS,7OUI,5LAT,5TIS,4US8,4US9,4USA,2J7Y,2J7X,7ADR,6KM0,6KM1,8EZ5,3SXM,3SXK,4RVY,4RVA,5KAF,5KAI,6N7F,7A24,7A23,4ZLA,1CAM,1CAH,6YP7,7KCT,8EQM,8F4J,8F4K,8F4H,8F4I,8F4F,8F4G,8F4D,8F4C,4XZ5,3VBI,3VBK,3VBM,3VBL,4EML,7D1P,7D1T,7D1U,7D1N,6SC3,7KBL,4KLR,7EDA,4LHC,3DTB,2QD2,4YBO,7Y7A,6DIK,7ZB1,6F89,2FDA,7PNK,6SC0,4I4Z,4I42,7ZYY,6KI1,5V2C,5DEI,7D2J,4CLL,5WS5,5WS6,5GTI,3AN1,6DHH,6DHO,6DHF,6DHG,6DHE,6DHP,1V67,3H8G,3H8F,4C80,3WAE,1DXK,2ESF,3AX7,3AX9,4Z7J,1ZSJ,1ZSK,6W1U,1CL1,7O9N,6MYP,6J40,3AM9,3AMZ,7Y5E,2D3I,2VVB,4ZI6,6SJ0,7AIZ,7PE4,6UJ6,6XR0,7VD5,5ZZN,7C5V,7C5X,1LGD,2E3T,4PBU,7NHO,4MV9,4MV3,1BVT,7CJI,7CJJ,3WU2,2E1Q,6J3Y,6J3Z,4Q2H,6WJ6,6IM0,5CXK,7RF8,7RF5,7RF4,7RF7,7RF6,7RF3,7RF2,1BIC,5E79,5E7C,4A1T,6AJU,4UB8,4UB6,4V62,8EPZ,1JF8,1QRL,1QRE,4DUR,5ADT,5ADR,5ADS,5ADQ,6SQX,3E3F,3E3I,3VM1,4QRO,5LBE,5LBF,5LBB,3JCU,5FBK,5FBH,6JLP,6JLU,6JLJ,6JLK,6JLL,6JLM,6JLN,6JLO,4X53,4TNJ,4TNK,4TNH,4TNI,5XNM,6AD4,6YVX,6YVZ,5GTH,4RFD,5NSM,5NSP,2I4C,2I4B,4EGS,4IT1,8F4E,4OYZ,2C1L,5H2F,1MZ4,3E2A,3KZI,5OX5,4IL6,7CZL,5XNL 769 57298696 28976 CHEMBL363707 DB01390 C00288 ZINC06827693 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50824827 [O-][I](=O)(=O)=O InChI=1S/HIO4/c2-1(3,4)5/h(H,2,3,4,5)/p-1 KHIWWQKSHDUIBK-UHFFFAOYSA-M 50159782 periodate Carbonic anhydrase 4 Homo sapiens 226000000 ChEMBL 10.1016/j.bmcl.2004.11.056 10.7270/Q22R3SDV 15664814 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50159782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50159782&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PEJ 1TB4 167232 104046184 29908 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50824834 NS(N)(=O)=O InChI=1S/H4N2O2S/c1-5(2,3)4/h(H4,1,2,3,4) NVBFHJWHLNUMCV-UHFFFAOYSA-N 26995 CHEMBL355001::H2NSO2NH2::sulfamamide::sulfamide::sulfamoylamine Carbonic anhydrase 4 Homo sapiens 880 ChEMBL 10.1016/j.bmcl.2004.11.056 10.7270/Q22R3SDV 15664814 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26995&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search FUS 6D2N 82267 57298705 48266 CHEMBL355001 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50824836 [O-][Br](=O)=O InChI=1S/BrHO3/c2-1(3)4/h(H,2,3,4)/p-1 SXDBWCPKPHAZSM-UHFFFAOYSA-M 50159787 BrO3(-)::Bromat::[BrO3](-)::bromate::trioxidobromate(1-) Carbonic anhydrase 4 Homo sapiens 128000000 ChEMBL 10.1016/j.bmcl.2004.11.056 10.7270/Q22R3SDV 15664814 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50159787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50159787&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 84979 104046189 29881 C19295 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50824841 [O-]S([O-])(=O)=O InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 QAOWNCQODCNURD-UHFFFAOYSA-L 26992 CHEMBL183495::SO4(2-)::SODIUM SULFATE::sulfate::sulfate ion Carbonic anhydrase 4 Homo sapiens 9000000 ChEMBL 10.1016/j.bmcl.2004.11.056 10.7270/Q22R3SDV 15664814 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26992&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SO4 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1117 57298702 29922 CHEMBL183495 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50824848 [O-][Cl](=O)=O InChI=1S/ClHO3/c2-1(3)4/h(H,2,3,4)/p-1 XTEGARKTQYYJKE-UHFFFAOYSA-M 50159791 chlorate Carbonic anhydrase 4 Homo sapiens 64900000 ChEMBL 10.1016/j.bmcl.2004.11.056 10.7270/Q22R3SDV 15664814 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50159791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50159791&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search LCO 1JEE 104770 104046193 17322 C01485 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50824850 [O-][Cl](=O)(=O)=O InChI=1S/ClHO4/c2-1(3,4)5/h(H,2,3,4,5)/p-1 VLTRZXGMWDSKGL-UHFFFAOYSA-M 36131 perchlorate::sodium perchlorate Carbonic anhydrase 4 Homo sapiens 767000000 ChEMBL 10.1016/j.bmcl.2004.11.056 10.7270/Q22R3SDV 15664814 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36131&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search LCP 4YGL,1RXE,1RXI,5OHH,4KXI,2V45,1JFV,2V3V 123351 103147778 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50824853 NS(O)(=O)=O InChI=1S/H3NO3S/c1-5(2,3)4/h(H3,1,2,3,4) IIACRCGMVDHOTQ-UHFFFAOYSA-N 26994 CHEMBL68253::H2NSO3H::sulfamic acid Carbonic anhydrase 4 Homo sapiens 930 ChEMBL 10.1016/j.bmcl.2004.11.056 10.7270/Q22R3SDV 15664814 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26994&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5987 57298704 48266 CHEMBL68253 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50824872 [O-][I](=O)=O InChI=1S/HIO3/c2-1(3)4/h(H,2,3,4)/p-1 ICIWUVCWSCSTAQ-UHFFFAOYSA-M 50159790 IO3(-)::[IO3](-)::iodate::iodatetrioxidoiodate(1-) Carbonic anhydrase 4 Homo sapiens 108700000 ChEMBL 10.1016/j.bmcl.2004.11.056 10.7270/Q22R3SDV 15664814 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50159790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50159790&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 84927 104046192 29904 C18366 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50824888 O[N+]([O-])=O InChI=1S/HNO3/c2-1(3)4/h(H,2,3,4) GRYLNZFGIOXLOG-UHFFFAOYSA-N 50152970 CHEMBL1352::HONO2::nitric acid Carbonic anhydrase 4 Homo sapiens 58700000 ChEMBL 10.1016/j.bmcl.2004.11.056 10.7270/Q22R3SDV 15664814 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50152970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50152970&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 944 104040972 29794 CHEMBL1352 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50824894 OC([O-])=O InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1 BVKZGUZCCUSVTD-UHFFFAOYSA-M 26986 CHEMBL363707::HCO3-::SODIUM BICARBONATE::bicarbonate ion::hydrogen carbonate Carbonic anhydrase 4 Homo sapiens 5700000 ChEMBL 10.1016/j.bmcl.2004.11.056 10.7270/Q22R3SDV 15664814 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26986&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BCT 3E2W,3V83,7R30,2JF9,2ILM,6YW0,6YW1,4ZJY,4IXQ,4IXR,4IXZ,4URF,2HC9,7PHO,4V82,3RV4,5B5E,7ADY,3G8C,4YRW,1ZTJ,3Q6J,5LHK,6OAD,7ZB0,7RF1,1HCB,6ABU,6VCF,6W1O,6W1V,6W1T,6W1R,6W1P,6W1Q,3HCN,3HCO,4WAK,6KAC,6KAF,6KAD,7PIN,7PIW,7PI5,7PI0,6KLZ,3U7C,7EVQ,5MX2,5B66,5LBC,2PIJ,4YSW,4Z9V,4FBY,7JRD,4LHD,5DRK,7RP9,7RPC,7RPB,7RPA,7RPF,7RPE,7RPD,5N4I,6WQP,4C7Z,4C7Y,1F9B,8GVC,6I33,6I35,6AC1,3OW5,6KM2,7ZAZ,7EGL,1S5L,4YTY,4YTZ,2A8D,7N8O,5ZJW,5TG6,5TG7,5TG4,5TG5,5OUF,6LV1,6LV2,6LV4,6LV6,6LV8,4PJ0,1YQW,3GLR,6A7X,5BXI,4DKI,4RY9,5NTD,5NTH,4H83,4WHQ,4WHP,4WHO,7YQ2,7YQ7,7ZZ3,7ZZ5,7EQU,3V7P,1OAO,2IST,2AXT,4K0X,4K0W,7COU,2BGS,4YUU,7RCV,3OU9,1VRG,7WK7,6G55,7N88,5D4O,5D4P,5O3Q,5O3R,3WDR,5HBC,3H02,5CRY,6DUX,1LI0,4ELS,1ZML,5ZAS,7OUI,5LAT,5TIS,4US8,4US9,4USA,2J7Y,2J7X,7ADR,6KM0,6KM1,8EZ5,3SXM,3SXK,4RVY,4RVA,5KAF,5KAI,6N7F,7A24,7A23,4ZLA,1CAM,1CAH,6YP7,7KCT,8EQM,8F4J,8F4K,8F4H,8F4I,8F4F,8F4G,8F4D,8F4C,4XZ5,3VBI,3VBK,3VBM,3VBL,4EML,7D1P,7D1T,7D1U,7D1N,6SC3,7KBL,4KLR,7EDA,4LHC,3DTB,2QD2,4YBO,7Y7A,6DIK,7ZB1,6F89,2FDA,7PNK,6SC0,4I4Z,4I42,7ZYY,6KI1,5V2C,5DEI,7D2J,4CLL,5WS5,5WS6,5GTI,3AN1,6DHH,6DHO,6DHF,6DHG,6DHE,6DHP,1V67,3H8G,3H8F,4C80,3WAE,1DXK,2ESF,3AX7,3AX9,4Z7J,1ZSJ,1ZSK,6W1U,1CL1,7O9N,6MYP,6J40,3AM9,3AMZ,7Y5E,2D3I,2VVB,4ZI6,6SJ0,7AIZ,7PE4,6UJ6,6XR0,7VD5,5ZZN,7C5V,7C5X,1LGD,2E3T,4PBU,7NHO,4MV9,4MV3,1BVT,7CJI,7CJJ,3WU2,2E1Q,6J3Y,6J3Z,4Q2H,6WJ6,6IM0,5CXK,7RF8,7RF5,7RF4,7RF7,7RF6,7RF3,7RF2,1BIC,5E79,5E7C,4A1T,6AJU,4UB8,4UB6,4V62,8EPZ,1JF8,1QRL,1QRE,4DUR,5ADT,5ADR,5ADS,5ADQ,6SQX,3E3F,3E3I,3VM1,4QRO,5LBE,5LBF,5LBB,3JCU,5FBK,5FBH,6JLP,6JLU,6JLJ,6JLK,6JLL,6JLM,6JLN,6JLO,4X53,4TNJ,4TNK,4TNH,4TNI,5XNM,6AD4,6YVX,6YVZ,5GTH,4RFD,5NSM,5NSP,2I4C,2I4B,4EGS,4IT1,8F4E,4OYZ,2C1L,5H2F,1MZ4,3E2A,3KZI,5OX5,4IL6,7CZL,5XNL 769 57298696 28976 CHEMBL363707 DB01390 C00288 ZINC06827693 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50824897 O[V](=O)=O InChI=1S/H2O.2O.V/h1H2;;;/q;;;+1/p-1 XDBSEZHMWGHVIL-UHFFFAOYSA-M 50094936 CHEMBL86473::Vanadate Carbonic anhydrase 4 Homo sapiens 44800000 ChEMBL 10.1016/j.bmcl.2004.11.056 10.7270/Q22R3SDV 15664814 Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50094936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50094936&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5463917 103992757 CHEMBL86473 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50822023 [O-]N=[CH+] InChI=1S/CHNO/c1-2-3/h1H UXKUODQYLDZXDL-UHFFFAOYSA-N 50152965 (methylidyneammoniumyl)oxidanide::CHEMBL185198::H-C#NO::HCNO::Knallsaeure::[C(H)NO]::[CH(NO)]::formonitrile oxideformonitrile-N-oxidehydrido(nitrosyl-kappaN)carbonhydrido(oxidonitrato-N)carbon::fulminic acid::hydrogen cyanide N-oxide::methylidyne(oxo)-lambda(5)-azane Carbonic anhydrase 4 Homo sapiens 30000 ChEMBL 10.1016/j.bmcl.2004.06.073 10.7270/Q2H995ZD 15357993 Innocenti, A; Zimmerman, S; Ferry, JG; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50152965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50152965&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 521293 104040968 29813 CHEMBL185198 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50822031 [O-]S([O-])(=O)=O InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 QAOWNCQODCNURD-UHFFFAOYSA-L 26992 CHEMBL183495::SO4(2-)::SODIUM SULFATE::sulfate::sulfate ion Carbonic anhydrase 4 Homo sapiens 44000000 ChEMBL 10.1016/j.bmcl.2004.06.073 10.7270/Q2H995ZD 15357993 Innocenti, A; Zimmerman, S; Ferry, JG; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26992&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SO4 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1117 57298702 29922 CHEMBL183495 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50822070 OC([O-])=O InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1 BVKZGUZCCUSVTD-UHFFFAOYSA-M 26986 CHEMBL363707::HCO3-::SODIUM BICARBONATE::bicarbonate ion::hydrogen carbonate Carbonic anhydrase 4 Homo sapiens 44000000 ChEMBL 10.1016/j.bmcl.2004.06.073 10.7270/Q2H995ZD 15357993 Innocenti, A; Zimmerman, S; Ferry, JG; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26986&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BCT 3E2W,3V83,7R30,2JF9,2ILM,6YW0,6YW1,4ZJY,4IXQ,4IXR,4IXZ,4URF,2HC9,7PHO,4V82,3RV4,5B5E,7ADY,3G8C,4YRW,1ZTJ,3Q6J,5LHK,6OAD,7ZB0,7RF1,1HCB,6ABU,6VCF,6W1O,6W1V,6W1T,6W1R,6W1P,6W1Q,3HCN,3HCO,4WAK,6KAC,6KAF,6KAD,7PIN,7PIW,7PI5,7PI0,6KLZ,3U7C,7EVQ,5MX2,5B66,5LBC,2PIJ,4YSW,4Z9V,4FBY,7JRD,4LHD,5DRK,7RP9,7RPC,7RPB,7RPA,7RPF,7RPE,7RPD,5N4I,6WQP,4C7Z,4C7Y,1F9B,8GVC,6I33,6I35,6AC1,3OW5,6KM2,7ZAZ,7EGL,1S5L,4YTY,4YTZ,2A8D,7N8O,5ZJW,5TG6,5TG7,5TG4,5TG5,5OUF,6LV1,6LV2,6LV4,6LV6,6LV8,4PJ0,1YQW,3GLR,6A7X,5BXI,4DKI,4RY9,5NTD,5NTH,4H83,4WHQ,4WHP,4WHO,7YQ2,7YQ7,7ZZ3,7ZZ5,7EQU,3V7P,1OAO,2IST,2AXT,4K0X,4K0W,7COU,2BGS,4YUU,7RCV,3OU9,1VRG,7WK7,6G55,7N88,5D4O,5D4P,5O3Q,5O3R,3WDR,5HBC,3H02,5CRY,6DUX,1LI0,4ELS,1ZML,5ZAS,7OUI,5LAT,5TIS,4US8,4US9,4USA,2J7Y,2J7X,7ADR,6KM0,6KM1,8EZ5,3SXM,3SXK,4RVY,4RVA,5KAF,5KAI,6N7F,7A24,7A23,4ZLA,1CAM,1CAH,6YP7,7KCT,8EQM,8F4J,8F4K,8F4H,8F4I,8F4F,8F4G,8F4D,8F4C,4XZ5,3VBI,3VBK,3VBM,3VBL,4EML,7D1P,7D1T,7D1U,7D1N,6SC3,7KBL,4KLR,7EDA,4LHC,3DTB,2QD2,4YBO,7Y7A,6DIK,7ZB1,6F89,2FDA,7PNK,6SC0,4I4Z,4I42,7ZYY,6KI1,5V2C,5DEI,7D2J,4CLL,5WS5,5WS6,5GTI,3AN1,6DHH,6DHO,6DHF,6DHG,6DHE,6DHP,1V67,3H8G,3H8F,4C80,3WAE,1DXK,2ESF,3AX7,3AX9,4Z7J,1ZSJ,1ZSK,6W1U,1CL1,7O9N,6MYP,6J40,3AM9,3AMZ,7Y5E,2D3I,2VVB,4ZI6,6SJ0,7AIZ,7PE4,6UJ6,6XR0,7VD5,5ZZN,7C5V,7C5X,1LGD,2E3T,4PBU,7NHO,4MV9,4MV3,1BVT,7CJI,7CJJ,3WU2,2E1Q,6J3Y,6J3Z,4Q2H,6WJ6,6IM0,5CXK,7RF8,7RF5,7RF4,7RF7,7RF6,7RF3,7RF2,1BIC,5E79,5E7C,4A1T,6AJU,4UB8,4UB6,4V62,8EPZ,1JF8,1QRL,1QRE,4DUR,5ADT,5ADR,5ADS,5ADQ,6SQX,3E3F,3E3I,3VM1,4QRO,5LBE,5LBF,5LBB,3JCU,5FBK,5FBH,6JLP,6JLU,6JLJ,6JLK,6JLL,6JLM,6JLN,6JLO,4X53,4TNJ,4TNK,4TNH,4TNI,5XNM,6AD4,6YVX,6YVZ,5GTH,4RFD,5NSM,5NSP,2I4C,2I4B,4EGS,4IT1,8F4E,4OYZ,2C1L,5H2F,1MZ4,3E2A,3KZI,5OX5,4IL6,7CZL,5XNL 769 57298696 28976 CHEMBL363707 DB01390 C00288 ZINC06827693 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50822079 [I-] InChI=1S/HI/h1H/p-1 XMBWDFGMSWQBCA-UHFFFAOYSA-M 26981 CHEMBL1644695::I-::POTASSIUM IODIDE::iodide::iodide ion Carbonic anhydrase 4 Homo sapiens 11000000 ChEMBL 10.1016/j.bmcl.2004.06.073 10.7270/Q2H995ZD 15357993 Innocenti, A; Zimmerman, S; Ferry, JG; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26981&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IDO 1ARX,1ARY,1B2K,1CMK,1CQW,1F09,1F3M,1GW9,1GWA,1GWD,1GWG,1GZA,1HC0,1HC9,1HUH,1J2J,1J99,1JWG,1LKR,1MOU,1MOV,1MXI,1N5M,1NJK,1NZB,1OJ5,1OUQ,1OVL,1OXS,1OXU,1OXV,1OXX,1PVH,1Q0T,1Q3U,1Q3V,1Q8C,1QI9,1QK0,1RLJ,1RRK,1RS0,1RTK,1S1M,1S6V,1SD5,1T1F,1T6C,1TUK,1U12,1U65,1UJK,1UTX,1V1F,1V1G,1VAT,1VKC,1VKO,1W2Z,1W50,1W51,1WC7,1WCB,1WCV,1WNW,1WY4,1XB7,1XC6,1XP4,1Y0S,1YDO,1YKU,1YRI,1ZCR,1ZVV,2A0N,2AF6,2AK4,2ANV,2ANX,2AQW,2ARL,2B9X,2BIV,2BMK,2C3N,2C3Q,2C3V,2CIW,2CJ6,2CJ7,2CJ8,2CKK,2CKL,2D8O,2D8P,2D8W,2D91,2D98,2DFB,2DFC,2DGM,2EDA,2EDC,2EIX,2ES4,2ESV,2EWJ,2FDS,2FWE,2FWF,2FWH,2GGQ,2GJM,2GQ2,2GS7,2GZB,2H9A,2HA0,2HA7,2HIB,2HQ6,2HRA,2I05,2I06,2I1W,2I8E,2ID1,2IPS,2IWK,2IZD,2IZQ,2J7P,2JJS,2NOO,2NQX,2O2B,2O86,2OF0,2OGS,2OGT,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2OJV,2OYY,2P4M,2PFI,2PUM,2Q2L,2QC5,2QCH,2QHX,2QPK,2QQT,2R5L,2REZ,2V8I,2VA5,2VA6,2VA7,2VBV,2VGZ,2VMA,2VUW,2YV7,2Z5Z,3BAS,3BCA,3BS9,3BV9,3CGP,3CJQ,3CT9,3D11,3DHX,3DY6,3E3T,3E7A,3EGV,3F6Q,3FNL 30165 57298691 64428 CHEMBL185537CHEMBL1644695 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50822080 [Cl-] InChI=1S/ClH/h1H/p-1 VEXZGXHMUGYJMC-UHFFFAOYSA-M 26979 CHEMBL69710::Cl-::POTASSIUM CHLORIDE::SODIUM CHLORIDE::chloride::chloride ion Carbonic anhydrase 4 Homo sapiens 36000000 ChEMBL 10.1016/j.bmcl.2004.06.073 10.7270/Q2H995ZD 15357993 Innocenti, A; Zimmerman, S; Ferry, JG; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26979&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CL 1W23,5QA9,5QA8,5QAF,5QAC,5QAO,7SUU,5QAX,5QAZ,3B3A,3B36,5QA5,5QA4,1Y6P,1Y6Q,1Y6G,5ETO,5ETX,5ETP,1K6X,1K6J,1K6I,1K6E,5QAE,5QAD,5QAG,1XV5,1XV8,5QAB,1K63,5QAM,5QAL,5QAU,5QAT,5QAW,5QAV,5QAQ,5QAP,5QAR,5QAY,7LNP,7LN9,7LN8,3LTD,3LTA,3LTC,3LTB,3LT9,3LT8,6O6Q,6BJD,6TW6,6TWP,6TWT,2NP0,4LCB,4LC8,4LC6,2ZDP,6Y6J,6Y65,6Y67,6PUJ,6PUG,6PUA,6PUC,6PUB,6PUX,6PU9,6PU1,1YL0,5Y2I,5Y2U,5Y2X,5Y2Y,1YLF,1GYH,1GYE,1GYW,1GYT,6WOP,6J1T,6J1Q,6J1P,6J1C,6J1B,6J1A,3GCF,6WO7,5FCZ,5FCU,5FCP,3GC2,1IHU,1IHA,1IHN,3QVM,3QVJ,3QVR,3QVP,3QVQ,3KWE,3KWD,3KWC,3KWK,3KW0,3LBB,3N65,3N64,3N66,3N61,3N60,3N63,3N62,4QNN,4QNL,4QNJ,4QNI,3N6X,3N6H,5CAJ,5CAI,5CAE,3AJN,3AJV,3AJX,5YXG,3U1W,7SGY,7SGX,1Z4U,7SGW,7SGV,6JKX,6JKZ,2BU3,2Q7B,2Q7C,2Q7X,2BUP,6K91,2BUJ,2BUF,2Q78,7A62,6DJ5,4LKT,8BFC,4Q4P,4Q4O,4Q4F,3NXS,3NXQ,6ZOU,6ZOA,4BG9,4BG8,4BGU,3RDK,3RDR,4C10,4C13,7R9C,4C1K,4C1L,4C1M,4NSV,7O3I,1F74,1F7T,1F7L,1F7B,8DTE,6F62,8AGH,8AGO,1EU8,6GFS,3WXT,3WXU,1SLT,4DNZ,4DNJ,4IMS,4IMU,4IMF,2QYC,7QIB,1Z47,4IM2,4IM3,1H87,1H80,6PH0,6PH1,8BGN,8J0V,8J0U,8J0Z,8J0X,8J0Y,6Z9A,6Z93,6IK6,4GB2,4AUV,1PPI,5SJT,5SJR,4GBU,4GBT,4GBM,4GBL,4GBN,4GBI,4GBK,4GBF,4GBC,2DXE,2AEE,2AER,4AUX,4YGD,4YGE,4YGF,4YGC,5N38,1FM0,1XDA,1FMV,1FMA,6Q4S,2O24,6Q4P,3VWI,2FJ9,246L,2FJ1,2FJN,3W6X,3W6A,1HBU,1HBM,1HBO,1HBN,1HBA,4TMZ,7ZSM,7BMX,7BMZ,7BMW,7BMP,7ZSH,6Q42,7ZSF,6Q40,7ZSG,7C5P,3I7R,3JW2,1O6B,1O6S,1O6T,1O6Z,6I58,6O6N,6I5X,6I5S,6I5B,6I5C,6I5D,3O8M,6TW5,5NYW,5NYK,5NYM,5NYE,7DBG,7DBA,5NY7,6RVM,4W97,4W91,6TWO,4W93,3BD1,6TWN,199L,6CYA,6CYZ,6CY6,7F6Q,7F6S,7F6T,7F6K,7F6E,5HNE,5HNO,5HNP,4M8L,4M8O,3Q2I,6QJ6,4M8K,7ZX2,3EH7,6QJX,6QJW,6QJA,5KK0,3O3L,5KKE,5KKI,5KKK,5KKJ,5KKY,1KAZ,1KAY,1KAX,2IT9,6Y6Y,2D4K,3ITD,6Y6A,2ITZ,7R31,4WMH,160L,4WMV,7R3L,7R3T,7R3Q,5O5M,4WM1,4WM2,4WM3,4WM4,4WM5,1W07,1W08,5EV8,5EVC,4LZM,4LZD,3OG3,3OGH,3PEI,1VDF,5QJA,5QJN,5QJT,1VDX,5QJZ,4ARA,4ARW,4ARU,3VRY,3VRZ,3VRC,2VSY,6DD4,1XMK,7LQY,6E03,3ZN5,3ZN4,3ZN6,6E0A,7LQ1,6E0V,3ZNV,3ZNJ,1NRX,5E5H,1NR5,3IWW,3C8Q,4W78,6NS0,6NSV,6NSX,6THA,6THE,4LXU,4A8E,2CF7,2CFV,3BPK,3BPR,1YYV,3TOZ,4JKX,4JKH,4JKD,4JKC,4JKB,4JKA,4JK9,4JK8,4JK7,4JK6,4JK5,6AEA,3UQ9,2X98,3UQU,4OL9,7WN7,3H4X,2YO3,2YO0,2YO1,2YOI,2YOL,2YOR,2YOZ,6WZ3,6WZ2,6WZ1,6WZ7,7CRL,7CRI,7CRJ,7CRK,7CRT,7CRS,7CRX,7CRY,6WZC,6WZA,6WZP,6WZU,8DV3,7EKK,7N3Z,7N3D,6T68,6T6O,6T6C,6T6G,7BD0,6YWO,4B2X,4B2W,4B2M,4B2H,4B2J,4B2K,4B2B,4B2C,2W5E,2W5B,7LWE,4ZJM,4ZJK,3HBV,3HBU,3HBN,6W08,3HB2,5VWM,5VWV,3K6M,3K6Q,2V6G,6MPT,6MPX,8I17,3NW8,3NW9,6LCN,3NWB,3NWD,3NWE,3NWN,6WOD,6WOF,6WOA,3MBY,3MBJ,3MBH,3MBD,3MB4,1UJ4,1UJ5,1UJ6,6WO8,6WO9,5FCD,2B4O,5FCC,3CQY,3CQO,3CQB,3CQE,6UAO,1ENN,6SET,3WMQ,3WMP,1SAW,3AUK,8AJP,4IXQ,4IXR,4IXT,4IXW,7B6B,2QTS,4IX8,2QT6,3AU2,3GJD,6URY,6UR3,5T5X,5T5P,5T5T,5T5L,4F78,4F71,2YIH,2YIL,3GJ2,2YIO,4GYZ,4GYL,4GYN,4GYO,4GYF,4GYB,5LHV,7WGT,7WGD,4UI0,6FUA,4UI1,6FU7,7BJB,1E4W,7BJD,1E42,7PTZ,7XO8,7XO9,3FF3,3FFC,4UIJ,5U16,5U1H,5U1O,5U1A,5U1Z,5U1Q,1HYZ,1HYU,1HYV,6L9Z,4CIE,3JZE,3JZD,3JZT,8G1Y,4QU6,7EFT,7S0U,2EEX,7ODH,7ODN,3OFW,7ODA,7ODG,7RDP,7OD0,1MOX,1MOG,1MOF,4QNZ,2Z2N,2Z2O,2Z2K,2Z2W,2OVZ,2OVX,2OV2,4MKK,4MKU,4MKS,7UKT,7UKP,7UKB,7V2T,6CLZ,3EE6,6D3M,3EEE,6D30,5HEZ,7P20,7P2B,7P2U,7P2T,7P2Z,4CPR,4CPW,2PMP,2PMU,2PMF,3PH5,3PH6,1TDR,8IBL,6DYF,6DYI,3VY5,3VY6,3VY7,2HC1,2HCF,4U87,5XZJ,4U6N,4U6Y,1QQN,7PHZ,7ZW2,3I36,2I58,2I54,2I55,2I52,3I3J,2DWW,3I3R,2I5X,5CX7,6NH1,6NH2,6NH3,6NH4,6NH5,6NH6,6NH8,6NHF,6NHS,6KCD,6KCB,5E97,5E98,6KC6,1S4N,1S4O,7JM6,7JM7,7JMQ,3NFZ,6MTH,7ETL,6MTZ,6MTW,6MTU,2V2Z,2V2H,6MT8,5OM1,5OM6,5OM5,5OM8,5OMY,5OMX,5OMC,5OMB,5OMI,6AHH,6AHS,6AHY,3UNH,3UNF,4ULX,4OS4,6V75,6V74,6V76,6V70,6V73,6V72,4OSF,4OSG,4V82,4U8W,3GYP,8ER7,5M56,4D4F,143L,1U16,4Y14,2C5W,2C5U,4Y1D,3U04,3DIB,3DIC,6VI5,3U0X,2XXV,2XXW,3DI8,3DI9,3DI7,3U0E,5JFF,5JFY,5JFU,5JFP,3G7U,3G7T,3G71,7UXZ,5VZ7,5VZ9,5VZG,5VZE,5VZC,5VZB,5VZH,7NPX,7NPG,7NPB,7NPA,7NPI,118L,7NP2,7NP8,1R85,1R87,1R86,5DKA,1R89,5DKX,2GLP,2GLV,2GLM,2GLL,4PJE,1R8K,3NBU,7MEL,4ZH5,3MOZ,3MOR,3MOG,1CPU,7QNQ,2WVO,7P11,7KT8,7KT9,7KT7,7KT4,7KT5,7KT3,7KT0,7KT1,7D4B,7KTN,7KTJ,7KTH,7KTG,7KTE,5WDJ,3CZ0,3CZ1,3CZ2,3CZ4,5WGI,5V0F,5V0W,5V0R,5V0X,5V0Z,5MY9,1JDB,5V01,1ZAN,4H1Z,6M8Y,6ZQ1,1JD7,3A6K,6UIE,6UIO,6M83,3RV4,5B5E,5B5Q,5B5U,1PJK,5B53 312 57298689 64428 CHEMBL19429CHEMBL69710 2339 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50822082 [Br-] InChI=1S/BrH/h1H/p-1 CPELXLSAUQHCOX-UHFFFAOYSA-M 26980 Br-::CHEMBL1644030::CHEMBL1644694::bromide::bromide ion Carbonic anhydrase 4 Homo sapiens 52000000 ChEMBL 10.1016/j.bmcl.2004.06.073 10.7270/Q2H995ZD 15357993 Innocenti, A; Zimmerman, S; Ferry, JG; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26980&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BR 1Y63,1XVC,1K6E,1K63,5Y24,2X42,2X40,2X41,1IHR,1XOK,2O29,7U5Q,1XMT,7WNL,7WNK,4B29,5VWW,3FFQ,2HC0,3I32,2V2Q,2V2V,5VZ4,4G6V,4KK6,6DRQ,2HTL,2HTK,4U9S,4U9Y,7PSF,4PM3,4BQO,1L0Z,3R1D,3R1E,1RER,5C0E,3DD7,2XMD,5C0T,5C0U,7QIK,2J3S,7M54,1QUI,1M3D,4YGJ,2HYP,4GP3,7TA2,4TM3,4TM1,4TM4,4DX8,4ICH,1OVL,3STV,6R62,5NGW,7L1E,2Q44,2IUO,2VR4,3ZOZ,8OKM,3GW6,6DDA,6DV1,7KK8,6VHX,6VHZ,6VHQ,6VHT,6VHU,6VHW,3MNG,5WC8,6FAQ,2FSX,7OP6,7OP7,1GED,1L1G,7Z57,5D5F,4DR9,6FN6,3FYS,4FBM,6EZ1,5AV2,6EZY,5AV4,1N8B,1VP6,3ZRG,8C7X,2B4G,3NEG,6LWY,6ZXX,7B9A,7KM7,7KM9,6G35,6HPD,6HPQ,6EQQ,6TQD,1IJV,4IO1,6I3A,3C9A,7ROO,2VQU,2VQT,7RDE,2XQ3,1EAO,5MNU,7QTX,3F2F,4TPY,4TPU,6CNU,5EXG,2VF3,3I18,6FZ6,3U6X,2WPF,4JRW,5JSP,5JSR,6H0A,7CUD,2J19,2J18,5H11,7DW5,1N9K,3Q4W,3LLP,7O21,7KK9,7T0H,7T0Y,1GQB,1GQP,5DSF,3SVD,3SVE,7QWI,6HSW,5M76,3V08,7L32,1IMX,3KLC,4R6C,6SMA,6GIV,4GAO,7RLM,1D2V,5HMJ,4WHI,2VPS,2VPM,5AV1,5GXY,5GXZ,1NUF,1NUD,2CIV,2CIZ,4LU4,6T36,6T38,2XPN,3MPR,6HTK,4F8L,4HC6,5S9S,7XBY,5U2P,1MHK,7P5T,2HLF,3DLU,4POD,4POC,4N6C,2WQ1,2WQ4,2XQG,3C51,4HH5,4HHQ,4HHO,3FPG,3FPF,3FPE,3FPJ,2EWF,4MY6,3LBO,2O2I,5G2A,1TO3,2XNT,5JTC,2QKI,7NBV,2AWD,2WDU,7O9R,5WV3,5MWK,3M3G,2HT4,2HT2,2HT3,2EZ0,7LGT,3LM7,7O5I,7O5T,7O5W,7O5V,7O5R,2ZC1,3BBZ,5LWQ,4JYE,4JYD,5LXR,5VEH,1F08,2QFE,4IFD,5NBX,5M65,8FC0,4QKO,3ONB,3ONC,6TS9,2BYD,6LZX,6LZY,6GJT,6RRV,2VOT,3F0O,3F0P,6GL4,6FY8,1Q3O,7KKR,6NLH,4H5B,2FPR,5L7F,1DOC,1DOE,2R4G,1RAZ,6M9G,5DZ6,7F9U,7F9V,8SA7,6S5H,7AS0,7O45,6BPA,4JXI,5FEA,1SR4,4R86,6R2N,3V6Q,5GXF,3O7O,6Y3A,5C5V,2X3H,5FHR,2J6L,6GKI,5SMJ,5FKR,367D,2FE8,4N8O,1D07,2HEK,4LS4,4LSI,4LSH,4LSE,4LSF,5SWA,3HNO,3A3K,6XQP,5EFH,1ROC,6SUT,7QJL,3TU8,3TUU,3LD5,6BZQ,6BZT,4CO6,5IL0,2FKK,3S8Y,2XHY,3DY9,3DYE,6GVA,5AMT,4ABL,8CIR,3Q17,1P2X,1YIY,1YIZ,1LZ9,1D7W,7QFK,4GIO,1PWX,6HTM,5S9W,5S9V,5S9U,5S9T,5S9Z,5S9Y,5S9X,7CXD,2DGL,7STU,3LZ3,6NX2,5LXY,6JU1,2VMF,6TF2,6TFE,6TFF,1WY0,4PWC,3F6O,4UJA,5U79,5U7C,5U7B,5U7A,2H34,5FKT,4KVH,4XY8,6PKY,2HI8,3R47,5OGX,6V9D,4HMK,7OW7,4MTM,3LEP,6PDK,7ECD,5I5P,6H42,6H45,1OSY,4ACK,2OJT,3LPH,2NTI,4M5X,6ARZ,3GGQ,6GBG,5SV6,3A0B,7M3R,1AZF,6QN3,7ZD4,7VTI,2YKF,7OLO,4C8U,5SCO,2FCV,4MO1,1KJL,1W99,7YUG,3MD9,4AZI,2VL4,7PD1,4LQK,2V6Q,8FHJ,4OWH,4OWB,5C9E,1EG6,3F75,7VGT,7VGU,7Q14,7OM3,8B3W,7SWS,4BWO,7Z00,5IUX,3UPT,6RO3,6MEI,4QH1,6P1M,6BXR,4K4R,1IZ8,6IYX,5FKS,6HM7,3G4Z,1JHD,6OMI,4Q7O,3LQL,3LQG,4P98,4P9P,4P9O,5OPP,4Q1U,1CIJ,8ADQ,4YD4,7KKB,7KKA,1FJ2,3EKI,5EUS,5AWX,2P3H,5FKQ,4ERR,4ER6,5CYQ,6FT9,7QQ7,7BEN,2G2P,7OCN,3X41,3X42,1MGY,1XEQ,7PEP,7REF,6W0S,7NUP,8ARC,7OLQ,7OLT,7OLK,7OLL,7OLM,4H3S,5LFT,6ZWI,6ZWE,4NKU,4NKT,4Y9F,4Y9C,4NSG,6RNU,4M5W,4KCO,4KCM,2CIX,2CIY,6YOD,6YOE,6YOB,6YOC,5YER,6Z6R,6Z6D,4R34,6Z8G,2RC3,2RC7,7O8Z,7O8Y,7O87,7FIB,3QBK,4Q2A,1F5M,3K9U,1HD2,3EJZ,3EJY,3O31,3USH,4B0O,3SSK,5MJ6,3WCR,5T7A,5GU5,5SAS,5SA3,5SA2,5SA1,5SA0,2VJX,5N7L,3CXM,3F59,5U82,5U83,5FQE,4DEY,6KTZ,4OXS,5IWO,5IWN,6ZVO,4PA3,5MPW,3BIY,1L9M,4QRY,3D7R,6K5I,6K5F,6K5D,6K5A,7A0H,3SRE,3SRG,2WBK,2WB9,6XKE,6S29,4B4P,1N0R,6AQK,6JL0,6KW0,4IL9,5SK7,5N2A,6QML,4W6T,6TII,6AD7,6AD8,6ADB,6ADA,3GUD,4P4G,5D5C,7QW3,4PA4,5ZQU,6D0G,8BAO,7PGO,3I4U,6TB7,6F01,4BRP,7KQ9,5GY1,5GY0,6XTD,3FLH,8CX9,4YEM,4Z0T,6KU2,8D87,4PA9,7TMD,3G99,5DAV,2WHR,2WH6,2VO5,6XAW,5M92,4C46,4KAH,5N6X,4XJF,4XJG,5Y9S,6YMN,4FBS,6K6J,4GOY,4GOV,5AHZ,3IVN,3M4H,6QGL,1N11,4GP0 259 57298690 64428 CHEMBL11685CHEMBL1644030CHEMBL1644694 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50847541 CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C19H27N3O7S2/c1-17(2)26-13-9-25-19(15(14(13)27-17)28-18(3,4)29-19)10-21-16(30)22-11-5-7-12(8-6-11)31(20,23)24/h5-8,13-15H,9-10H2,1-4H3,(H2,20,23,24)(H2,21,22,30)/t13-,14-,15+,19+/m1/s1 OKQRJNSDZLFCKE-CUYVQJCZSA-N 50208754 1-(4-sulfamoylphenyl)-3-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}thiourea::CHEMBL232616 Carbonic anhydrase 4 Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2007.03.008 10.7270/Q2VM4D3D 17376683 Winum, JY; Thiry, A; Cheikh, KE; Dogne, JM; Montero, JL; Vullo, D; Scozzafava, A; Masereel, B; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208754&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44430518 104085722 CHEMBL232616 ZINC28818623 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50847542 CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 KJADKKWYZYXHBB-XBWDGYHZSA-N 10887 Sulfamate 7::Topiramate (TPM)::US11535599, Example topiramate::[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate Carbonic anhydrase 4 Homo sapiens 4900 ChEMBL 10.1016/j.bmcl.2007.03.008 10.7270/Q2VM4D3D 17376683 Winum, JY; Thiry, A; Cheikh, KE; Dogne, JM; Montero, JL; Vullo, D; Scozzafava, A; Masereel, B; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10887&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TOR 3LXE,3HKU,5JNA 5284627 46511457 63631 DB00273 6849 C07502 ZINC01530804 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50847543 CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)NCCc4ccc(cc4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C21H31N3O7S2/c1-19(2)28-15-11-27-21(17(16(15)29-19)30-20(3,4)31-21)12-24-18(32)23-10-9-13-5-7-14(8-6-13)33(22,25)26/h5-8,15-17H,9-12H2,1-4H3,(H2,22,25,26)(H2,23,24,32)/t15-,16-,17+,21+/m1/s1 QLBNWGYCFZRBTF-VWXURSGXSA-N 50208749 1-[2-(4-sulfamoylphenyl)ethyl]-3-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}thiourea::CHEMBL390035 Carbonic anhydrase 4 Homo sapiens 850 ChEMBL 10.1016/j.bmcl.2007.03.008 10.7270/Q2VM4D3D 17376683 Winum, JY; Thiry, A; Cheikh, KE; Dogne, JM; Montero, JL; Vullo, D; Scozzafava, A; Masereel, B; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208749&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44430517 104085717 CHEMBL390035 ZINC28818625 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50847546 CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4cccc(c4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C19H27N3O7S2/c1-17(2)26-13-9-25-19(15(14(13)27-17)28-18(3,4)29-19)10-21-16(30)22-11-6-5-7-12(8-11)31(20,23)24/h5-8,13-15H,9-10H2,1-4H3,(H2,20,23,24)(H2,21,22,30)/t13-,14-,15+,19+/m1/s1 FZBBHBCZJLNRCC-CUYVQJCZSA-N 50208752 1-(3-sulfamoylphenyl)-3-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}thiourea::CHEMBL232617 Carbonic anhydrase 4 Homo sapiens 30700 ChEMBL 10.1016/j.bmcl.2007.03.008 10.7270/Q2VM4D3D 17376683 Winum, JY; Thiry, A; Cheikh, KE; Dogne, JM; Montero, JL; Vullo, D; Scozzafava, A; Masereel, B; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208752&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44430520 104085720 CHEMBL232617 ZINC28818631 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50847553 CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4F)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C19H26FN3O7S2/c1-17(2)27-13-8-26-19(15(14(13)28-17)29-18(3,4)30-19)9-22-16(31)23-12-6-5-10(7-11(12)20)32(21,24)25/h5-7,13-15H,8-9H2,1-4H3,(H2,21,24,25)(H2,22,23,31)/t13-,14-,15+,19+/m1/s1 CLNZVLYLUNHHJW-CUYVQJCZSA-N 50208751 1-(2-fluoro-4-sulfamoylphenyl)-3-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}thiourea::CHEMBL233019 Carbonic anhydrase 4 Homo sapiens 43700 ChEMBL 10.1016/j.bmcl.2007.03.008 10.7270/Q2VM4D3D 17376683 Winum, JY; Thiry, A; Cheikh, KE; Dogne, JM; Montero, JL; Vullo, D; Scozzafava, A; Masereel, B; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208751&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 17748220 104085719 CHEMBL233019 ZINC28818633 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50847555 CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4Cl)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C19H26ClN3O7S2/c1-17(2)27-13-8-26-19(15(14(13)28-17)29-18(3,4)30-19)9-22-16(31)23-12-6-5-10(7-11(12)20)32(21,24)25/h5-7,13-15H,8-9H2,1-4H3,(H2,21,24,25)(H2,22,23,31)/t13-,14-,15+,19+/m1/s1 JRTAARITAXOAAO-CUYVQJCZSA-N 50208755 1-(2-chloro-4-sulfamoylphenyl)-3-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}thiourea::CHEMBL232816 Carbonic anhydrase 4 Homo sapiens 1040 ChEMBL 10.1016/j.bmcl.2007.03.008 10.7270/Q2VM4D3D 17376683 Winum, JY; Thiry, A; Cheikh, KE; Dogne, JM; Montero, JL; Vullo, D; Scozzafava, A; Masereel, B; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208755&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44430521 104085723 CHEMBL232816 ZINC28818632 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50847557 CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4F)S(=O)(=O)NCc4ccc(cc4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C26H33FN4O9S3/c1-24(2)37-20-13-36-26(22(21(20)38-24)39-25(3,4)40-26)14-29-23(41)31-19-10-9-17(11-18(19)27)43(34,35)30-12-15-5-7-16(8-6-15)42(28,32)33/h5-11,20-22,30H,12-14H2,1-4H3,(H2,28,32,33)(H2,29,31,41)/t20-,21-,22+,26+/m1/s1 LEWGDIPTXPUENR-CQAGSAPUSA-N 50208753 1-(2-fluoro-4-{[(4-sulfamoylphenyl)methyl]sulfamoyl}phenyl)-3-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}thiourea::CHEMBL395734 Carbonic anhydrase 4 Homo sapiens 670 ChEMBL 10.1016/j.bmcl.2007.03.008 10.7270/Q2VM4D3D 17376683 Winum, JY; Thiry, A; Cheikh, KE; Dogne, JM; Montero, JL; Vullo, D; Scozzafava, A; Masereel, B; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208753&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44430523 104085721 CHEMBL395734 ZINC28818634 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50847578 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2007.03.008 10.7270/Q2VM4D3D 17376683 Winum, JY; Thiry, A; Cheikh, KE; Dogne, JM; Montero, JL; Vullo, D; Scozzafava, A; Masereel, B; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50847581 CC1(C)O[C@@H]2CO[C@@]3(CNC(=S)Nc4ccc(cc4F)S(=O)(=O)Nc4nnc(s4)S(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C21H27FN6O9S4/c1-19(2)34-13-8-33-21(15(14(13)35-19)36-20(3,4)37-21)9-24-16(38)25-12-6-5-10(7-11(12)22)41(31,32)28-17-26-27-18(39-17)40(23,29)30/h5-7,13-15H,8-9H2,1-4H3,(H,26,28)(H2,23,29,30)(H2,24,25,38)/t13-,14-,15+,21+/m1/s1 BTMYCYUSKNWPJE-MBIULKOWSA-N 50208750 1-{2-fluoro-4-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-3-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}thiourea::CHEMBL395981 Carbonic anhydrase 4 Homo sapiens 89300 ChEMBL 10.1016/j.bmcl.2007.03.008 10.7270/Q2VM4D3D 17376683 Winum, JY; Thiry, A; Cheikh, KE; Dogne, JM; Montero, JL; Vullo, D; Scozzafava, A; Masereel, B; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208750&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44430524 104085718 CHEMBL395981 ZINC28818635 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50851973 CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 KJADKKWYZYXHBB-XBWDGYHZSA-N 10887 Sulfamate 7::Topiramate (TPM)::US11535599, Example topiramate::[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate Carbonic anhydrase 4 Homo sapiens 4900 ChEMBL 10.1016/j.bmc.2007.04.020 10.7270/Q28916QG 17475500 Supuran, CT; Scozzafava, A Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10887&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TOR 3LXE,3HKU,5JNA 5284627 46511457 63631 DB00273 6849 C07502 ZINC01530804 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50851998 CC(=O)N=c1sc(nn1C)S(N)(=O)=O InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) FLOSMHQXBMRNHR-UHFFFAOYSA-N 10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid_4100::sulfonamide 2 Carbonic anhydrase 4 Homo sapiens 6200 ChEMBL 10.1016/j.bmc.2007.04.020 10.7270/Q28916QG 17475500 Supuran, CT; Scozzafava, A Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10881&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search MZM 4K0Z,4YHA,5KU6,1BZM,5C8I,3DAZ,3DCS 4100 46511451 CHEMBL288100 6828 ZINC12503151 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50852013 CC1(C)O[C@@H]2CO[C@@]3(CNS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H22N2O7S/c1-10(2)18-7-5-17-12(6-14-22(13,15)16)9(8(7)19-10)20-11(3,4)21-12/h7-9,14H,5-6H2,1-4H3,(H2,13,15,16)/t7-,8-,9+,12+/m1/s1 NQRKKQKMTGLNOZ-XBWDGYHZSA-N 13055 CHEMBL283695::Compound 8::Topiramate Sulfamide Analogue 8::amino-N-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}sulfonamide Carbonic anhydrase 4 Homo sapiens 941 ChEMBL 10.1016/j.bmc.2007.04.020 10.7270/Q28916QG 17475500 Supuran, CT; Scozzafava, A Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13055&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search B19 2H15 10712038 46513475 CHEMBL283695 ZINC13612331 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50852044 NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) GJQPMPFPNINLKP-UHFFFAOYSA-N 10883 4,5-dichlorobenzene-1,3-disulfonamide::CHEMBL17::Dichlorophenamide::Dichlorophenamide (DCP)::Dichlorophenamide, DCP::Sulfonamide, 4::US10172837, Dichlorphenamide::sulfonamide 4 Carbonic anhydrase 4 Homo sapiens 15000 ChEMBL 10.1016/j.bmc.2007.04.020 10.7270/Q28916QG 17475500 Supuran, CT; Scozzafava, A Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10883&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search I7A 2POU 3038 46511453 101085 CHEMBL17 DB01144 6807 C07459 ZINC00896918 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50852063 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2007.04.020 10.7270/Q28916QG 17475500 Supuran, CT; Scozzafava, A Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50852072 CCOc1ccc2nc(sc2c1)S(N)(=O)=O InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) OUZWUKMCLIBBOG-UHFFFAOYSA-N 10882 6-ethoxy-1,3-benzothiazole-2-sulfonamide::CHEMBL18::Ethamide::Ethoxazolamide::Ethoxzolamide::Ethoxzolamide (EZA)::Ethoxzolamide, EZM::Sulfonamide, 3::US10172837, Ethoxyzolamide::sulfonamide 3 Carbonic anhydrase 4 Homo sapiens 93 ChEMBL 10.1016/j.bmc.2007.04.020 10.7270/Q28916QG 17475500 Supuran, CT; Scozzafava, A Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10882&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EZL 3DD0,5JN9,3CAJ,3MDZ,6BCC,3DCW,6QL2,5TT3,6MWI 3295 46511452 101096 CHEMBL18 DB00311 6814 ZINC00056721 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50852083 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 IAVUPMFITXYVAF-XPUUQOCRSA-N 10884 (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide::Dorzolamide (DRZ)::Dorzolamide (DZA) Carbonic anhydrase 4 Homo sapiens 8500 ChEMBL 10.1016/j.bmc.2007.04.020 10.7270/Q28916QG 17475500 Supuran, CT; Scozzafava, A Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10884&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ETS 4M2W,4M2U,4K13,3FW3,6BC9,1CIL 5284549 46511454 4702 DB00869 6810 C06969 ZINC01530621 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50847268 [O-]C(=O)P([O-])([O-])=O InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3 ZJAOAACCNHFJAH-UHFFFAOYSA-K 50027536 (phosphonoformate)Trisodium phosphonoformate::Antiviral agent : Inhibitor of reverse transcriptase of Human T-cell lymphotropic, virus type III, useful in the treatment of HSV-1 infections::CHEMBL754::EHB-776::FOSCARNET SODIUM::Foscarnet::Foscavir::phosphonoformate trisodium salt::trisodium dioxidophosphinecarboxylate oxide::trisodium dioxidophosphinecarboxylate oxide with 6 molecules of water(foscarnet)::trisodium phosphonoformate Carbonic anhydrase 4 Homo sapiens 820000 ChEMBL 10.1016/j.bmcl.2007.01.113 10.7270/Q21C1XP7 17314045 Temperini, C; Innocenti, A; Guerri, A; Scozzafava, A; Rusconi, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50027536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50027536&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3414 103937006 141644 CHEMBL754 C06456 ZINC24629762 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50866587 NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1)S(N)(=O)=O InChI=1S/C15H14N4O3S/c16-19-15(20)14-13(9-4-2-1-3-5-9)11-8-10(23(17,21)22)6-7-12(11)18-14/h1-8,18H,16H2,(H,19,20)(H2,17,21,22) PPDLAUCFAOODER-UHFFFAOYSA-N 25904 2-(hydrazinecarbonyl)-3-phenyl-1H-indole-5-sulfonamide::BMC173212 Compound 1::CHEMBL262628::indole sulfonamide, L Carbonic anhydrase 4 Homo sapiens 9000 ChEMBL 10.1016/j.bmcl.2008.03.023 10.7270/Q23R0TRX 18359629 Di Fiore, A; Pedone, C; Antel, J; Waldeck, H; Witte, A; Wurl, M; Scozzafava, A; Supuran, CT; De Simone, G Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25904&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TUO 3B4F 14611919 56413192 CHEMBL262628 DB08659 ZINC24959962 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50866588 CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1 HCRKCZRJWPKOAR-JTQLQIEISA-N 10885 (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::(R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-E)-1,2-thiazine-6-sulfonamide 1,1-dioxide::AL-4862::Azopt::Brinzolamide (BRZ)::brinzolamide Carbonic anhydrase 4 Homo sapiens 3950 ChEMBL 10.1016/j.bmcl.2008.03.023 10.7270/Q23R0TRX 18359629 Di Fiore, A; Pedone, C; Antel, J; Waldeck, H; Witte, A; Wurl, M; Scozzafava, A; Supuran, CT; De Simone, G Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10885&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BZ1 3ZNC,4M2V,4M2R,6BBS 68844 46511455 3176 DB01194 6797 C07760 ZINC03953037 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50866589 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 IAVUPMFITXYVAF-XPUUQOCRSA-N 10884 (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide::Dorzolamide (DRZ)::Dorzolamide (DZA) Carbonic anhydrase 4 Homo sapiens 8500 ChEMBL 10.1016/j.bmcl.2008.03.023 10.7270/Q23R0TRX 18359629 Di Fiore, A; Pedone, C; Antel, J; Waldeck, H; Witte, A; Wurl, M; Scozzafava, A; Supuran, CT; De Simone, G Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10884&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ETS 4M2W,4M2U,4K13,3FW3,6BC9,1CIL 5284549 46511454 4702 DB00869 6810 C06969 ZINC01530621 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50866590 CCOc1ccc2nc(sc2c1)S(N)(=O)=O InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) OUZWUKMCLIBBOG-UHFFFAOYSA-N 10882 6-ethoxy-1,3-benzothiazole-2-sulfonamide::CHEMBL18::Ethamide::Ethoxazolamide::Ethoxzolamide::Ethoxzolamide (EZA)::Ethoxzolamide, EZM::Sulfonamide, 3::US10172837, Ethoxyzolamide::sulfonamide 3 Carbonic anhydrase 4 Homo sapiens 93 ChEMBL 10.1016/j.bmcl.2008.03.023 10.7270/Q23R0TRX 18359629 Di Fiore, A; Pedone, C; Antel, J; Waldeck, H; Witte, A; Wurl, M; Scozzafava, A; Supuran, CT; De Simone, G Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10882&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EZL 3DD0,5JN9,3CAJ,3MDZ,6BCC,3DCW,6QL2,5TT3,6MWI 3295 46511452 101096 CHEMBL18 DB00311 6814 ZINC00056721 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50866591 CC(=O)N=c1sc(nn1C)S(N)(=O)=O InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) FLOSMHQXBMRNHR-UHFFFAOYSA-N 10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid_4100::sulfonamide 2 Carbonic anhydrase 4 Homo sapiens 6200 ChEMBL 10.1016/j.bmcl.2008.03.023 10.7270/Q23R0TRX 18359629 Di Fiore, A; Pedone, C; Antel, J; Waldeck, H; Witte, A; Wurl, M; Scozzafava, A; Supuran, CT; De Simone, G Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10881&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search MZM 4K0Z,4YHA,5KU6,1BZM,5C8I,3DAZ,3DCS 4100 46511451 CHEMBL288100 6828 ZINC12503151 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50866633 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2008.03.023 10.7270/Q23R0TRX 18359629 Di Fiore, A; Pedone, C; Antel, J; Waldeck, H; Witte, A; Wurl, M; Scozzafava, A; Supuran, CT; De Simone, G Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50866642 NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) GJQPMPFPNINLKP-UHFFFAOYSA-N 10883 4,5-dichlorobenzene-1,3-disulfonamide::CHEMBL17::Dichlorophenamide::Dichlorophenamide (DCP)::Dichlorophenamide, DCP::Sulfonamide, 4::US10172837, Dichlorphenamide::sulfonamide 4 Carbonic anhydrase 4 Homo sapiens 95 ChEMBL 10.1016/j.bmcl.2008.03.023 10.7270/Q23R0TRX 18359629 Di Fiore, A; Pedone, C; Antel, J; Waldeck, H; Witte, A; Wurl, M; Scozzafava, A; Supuran, CT; De Simone, G Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10883&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search I7A 2POU 3038 46511453 101085 CHEMBL17 DB01144 6807 C07459 ZINC00896918 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880615 O=[Ru](=O)(=O)=O InChI=1S/4O.Ru/q;;;;-1 HQCNJYGPTIMPSR-UHFFFAOYSA-N 50278324 CHEMBL471246::sodium perruthenate Carbonic anhydrase 4 Homo sapiens 1060000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50278324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50278324&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 119079 104120670 CHEMBL471246 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880646 [O-][Sn]([O-])=O InChI=1S/3O.Sn/q;2*-1; YRIKDNGZJWUTDN-UHFFFAOYSA-N 50278312 CHEMBL445433::sodium stannate(IV) Carbonic anhydrase 4 Homo sapiens 640000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50278312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50278312&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25502 104120658 CHEMBL445433 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880647 [O-][Se]([O-])(=O)=O InChI=1S/H2O4Se/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 QYHFIVBSNOWOCQ-UHFFFAOYSA-L 50130701 CHEMBL114503::lambda~4~-selenium oxide; disodium::sodium selenate::sodium selenate(VI) Carbonic anhydrase 4 Homo sapiens 138000000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130701&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SE4 3QMP,2V0B,5E3U,3MJ3,1FGA,3MJA,2V8B 26473 104022010 18170 CHEMBL114503 C05697 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880648 [O-][Te]([O-])(=O)=O InChI=1S/H2O4Te/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 XHGGEBRKUWZHEK-UHFFFAOYSA-L 50278313 CHEMBL471869::sodium tellurate(VI) Carbonic anhydrase 4 Homo sapiens 270000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50278313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50278313&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5460475 104120659 CHEMBL471869 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880649 [O-][Os]([O-])(=O)(=O)=O InChI=1S/5O.Os/q;;;;;-2 OCNNBYRXULLCFR-UHFFFAOYSA-N 50278314 CHEMBL1076628::sodium perosmate(VIII) Carbonic anhydrase 4 Homo sapiens 1060000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50278314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50278314&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 104120660 CHEMBL1076628 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880650 [O-]S(=O)(=O)OS([O-])(=O)=O InChI=1S/H2O7S2/c1-8(2,3)7-9(4,5)6/h(H,1,2,3)(H,4,5,6)/p-2 VFNGKCDDZUSWLR-UHFFFAOYSA-L 50278315 CHEMBL111016::sodium pyrosulfate Carbonic anhydrase 4 Homo sapiens 1100000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50278315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50278315&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PSL 4WWZ,1YKJ 177717 104120661 CHEMBL111016 C02000 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880651 [O-]P([O-])(=O)OP([O-])([O-])=O InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-4 XPPKVPWEQAFLFU-UHFFFAOYSA-J 50278316 CHEMBL450079::sodium pyrophosphate(V) Carbonic anhydrase 4 Homo sapiens 1010000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50278316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50278316&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search DPO 6WO1,6E0M,8E8E,2F7F,6J7F,2VG2,4L7I,8E8H,8E8G,8E8F,5YUY,5YUX,4ECX,4ECT,4ECU,4ECV,4ECW,4ECS,4K0B,6K27,1N5L,5D4E,6IG1,6NL7,5KFK,5KFH,5KFI,5KFZ,5KFR,5ZLV,7CC3,4CU4,6K32,3QQS,4DI5,7U7J,5ESS,5LX5,5YV0,5YV1,5YV3,1KKF,3H20,7CAV,7CAS,6UTW,6UTV,6UTZ,6KI8,1PVF,3D40,7M7Z,1FI1,5KG5,5KG4,5KG7,5KG6,5KG1,5KG0,5KG3,5KG2,4L2Z,7M8D,7M8A,7M8B,7M8C,7M86,7M87,7M80,7M81,7M82,7M88,6UU5,6UU8,6UU9,6BPL,4RNQ,1WXI,3R20,4S3D,5YUZ,1QJQ,4IJX,5KFJ,5KFL,5KFX,5KFP,5KFQ,5KFW,8AOZ,1QKC,3KOA,6OS5,2DTN,7U7A,7U7G,7U7F,7U76,7U79,2GRX,1QFF,1QFG,3CRQ,3CRR,7U7K,2O1S,7U7C,7U7B,7U7I,7U7L,5L9X,5IPL,5O6K,1RQI,5ILY,7EJ3,6UGJ,5IK6,5IKA 644102 104120662 18361 CHEMBL450079 DB04160 C00013 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880652 [O-][V]([O-])(=O)O[V]([O-])([O-])=O InChI=1S/7O.2V/q;;;4*-1;; FLMHWEUYESKOIA-UHFFFAOYSA-N 50333131 CHEMBL1075630::sodium pyrovanadate(V)::tetrasodium {[dioxido(oxo)vanadio]oxy}(oxo)vanadiumbis(olate) Carbonic anhydrase 4 Homo sapiens 290000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333131&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4608376 125083233 CHEMBL1075630 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880653 [O-][Re](=O)(=O)=O InChI=1S/4O.Re/q;;;-1; WPWXHJFQOFOBAC-UHFFFAOYSA-N 50278318 CHEMBL444819::sodium perrhenate(VII) Carbonic anhydrase 4 Homo sapiens 920000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50278318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50278318&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search REO 7UUZ,1K4J,3AXF,3R26,1HNU 139584 104120664 CHEMBL444819 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880654 [O-]S(=O)(=O)OOS([O-])(=O)=O InChI=1S/H2O8S2/c1-9(2,3)7-8-10(4,5)6/h(H,1,2,3)(H,4,5,6)/p-2 JRKICGRDRMAZLK-UHFFFAOYSA-L 50278319 CHEMBL502764::sodium persulfate Carbonic anhydrase 4 Homo sapiens 1000000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50278319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50278319&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 107879 104120665 CHEMBL502764 C02000 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880655 [N-]=C=[Se] InChI=1S/CNSe/c2-1-3/q-1 VMBLRVCGTJUTIQ-UHFFFAOYSA-N 50278320 CHEMBL2069541::CHEMBL448089::sodium selenocyanate Carbonic anhydrase 4 Homo sapiens 850000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50278320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50278320&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 76961 104120666 CHEMBL2069541CHEMBL448089 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880656 [O-]S(=O)(=O)NS([O-])(=O)=O InChI=1S/H3NO6S2/c2-8(3,4)1-9(5,6)7/h1H,(H,2,3,4)(H,5,6,7)/p-2 VKHQYTLHHOQKSC-UHFFFAOYSA-L 50278321 CHEMBL471244::sodium iminodisulfonate Carbonic anhydrase 4 Homo sapiens 1000000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50278321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50278321&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5157540 104120667 CHEMBL471244 C01614 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880657 [O-]S(F)(=O)=O InChI=1S/FHO3S/c1-5(2,3)4/h(H,2,3,4)/p-1 UQSQSQZYBQSBJZ-UHFFFAOYSA-M 50278322 CHEMBL450253::sodium fluorosulfate Carbonic anhydrase 4 Homo sapiens 39660000 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50278322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50278322&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3413884 104120668 CHEMBL450253 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880658 [S-]C([S-])=S InChI=1S/CH2S3/c2-1(3)4/h(H2,2,3,4)/p-2 HIZCIEIDIFGZSS-UHFFFAOYSA-L 50278323 CHEMBL471245::sodium trithiocarbonate Carbonic anhydrase 4 Homo sapiens 9900 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50278323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50278323&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 16020005 104120669 CHEMBL471245 ZINC44418363 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50880659 CCN(CC)C([S-])=S InChI=1S/C5H11NS2/c1-3-6(4-2)5(7)8/h3-4H2,1-2H3,(H,7,8)/p-1 LMBWSYZSUOEYSN-UHFFFAOYSA-M 50010231 CHEMBL107217::Ditiocarb sodium::Sodium salt of Diethyl-dithiocarbamic acid(DDC)::US9180183, DDTC::sodium N,N-diethyl-dithiocarbamate::sodium diethyldithiocarbamate Carbonic anhydrase 4 Homo sapiens 6500 ChEMBL 10.1016/j.bmcl.2009.02.088 10.7270/Q27H1KH3 19269822 Innocenti, A; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010231&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 28343 103923074 CHEMBL107217 C19570 ZINC03633221 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878374 NS(=O)(=O)Cc1noc2ccccc12 InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12) UBQNRHZMVUUOMG-UHFFFAOYSA-N 10888 1,2-benzoxazol-3-ylmethanesulfonamide::CHEMBL750::SPR_2::US10172837, Zonisamide::Zonisamide::Zonisamide (ZNA)::Zonisamide (ZNS)::Zonisamide, 1::Zonisamide, ZNS Carbonic anhydrase 4 Homo sapiens 8590 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10888&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ZON 3PO7 5734 46511458 10127 CHEMBL750 DB00909 7047 C07504 ZINC00004321 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878375 CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 KJADKKWYZYXHBB-XBWDGYHZSA-N 10887 Sulfamate 7::Topiramate (TPM)::US11535599, Example topiramate::[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate Carbonic anhydrase 4 Homo sapiens 4900 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10887&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TOR 3LXE,3HKU,5JNA 5284627 46511457 63631 DB00273 6849 C07502 ZINC01530804 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878376 NS(=O)(=O)Nc1nncs1 InChI=1S/C2H4N4O2S2/c3-10(7,8)6-2-5-4-1-9-2/h1H,(H,5,6)(H2,3,7,8) TXIIDPYBTNXTDC-UHFFFAOYSA-N 50256509 CHEMBL449527::N-1,3,4-thiadiazol-2-ylsulfamide Carbonic anhydrase 4 Homo sapiens 8910 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256509&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25154729 104107967 CHEMBL449527 ZINC40981143 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878377 CCc1nnc(NS(N)(=O)=O)s1 InChI=1S/C4H8N4O2S2/c1-2-3-6-7-4(11-3)8-12(5,9)10/h2H2,1H3,(H,7,8)(H2,5,9,10) HVRGNGCSIVHKLU-UHFFFAOYSA-N 50256510 CHEMBL500977::N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide Carbonic anhydrase 4 Homo sapiens 8640 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256510&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25154730 104107968 CHEMBL500977 ZINC39121736 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878378 CC(C)(C)c1nnc(NS(N)(=O)=O)s1 InChI=1S/C6H12N4O2S2/c1-6(2,3)4-8-9-5(13-4)10-14(7,11)12/h1-3H3,(H,9,10)(H2,7,11,12) JJBJNTIFYMQMKH-UHFFFAOYSA-N 50256511 CHEMBL475775::N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide Carbonic anhydrase 4 Homo sapiens 8400 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256511&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44571846 104107969 CHEMBL475775 ZINC40917673 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878379 NS(=O)(=O)Nc1nnc(s1)C(F)(F)F InChI=1S/C3H3F3N4O2S2/c4-3(5,6)1-8-9-2(13-1)10-14(7,11)12/h(H,9,10)(H2,7,11,12) OACDKBCLUXHEPC-UHFFFAOYSA-N 50256512 CHEMBL499560::N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]sulfamide Carbonic anhydrase 4 Homo sapiens 4320 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256512&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44571847 104107970 CHEMBL499560 ZINC40975068 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878380 CSc1nnc(NS(N)(=O)=O)s1 InChI=1S/C3H6N4O2S3/c1-10-3-6-5-2(11-3)7-12(4,8)9/h1H3,(H,5,7)(H2,4,8,9) AJEMPSSJQSOJKR-UHFFFAOYSA-N 50256513 CHEMBL459356::N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide Carbonic anhydrase 4 Homo sapiens 8300 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256513&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44571848 104107971 CHEMBL459356 ZINC40918570 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878381 CCSc1nnc(NS(N)(=O)=O)s1 InChI=1S/C4H8N4O2S3/c1-2-11-4-7-6-3(12-4)8-13(5,9)10/h2H2,1H3,(H,6,8)(H2,5,9,10) CHUOTDNKSODBJL-UHFFFAOYSA-N 50256514 CHEMBL451538::N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide Carbonic anhydrase 4 Homo sapiens 7580 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256514&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25154731 104107972 CHEMBL451538 ZINC40835999 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878382 NS(=O)(=O)Nc1nnc(s1)-c1ccccc1 InChI=1S/C8H8N4O2S2/c9-16(13,14)12-8-11-10-7(15-8)6-4-2-1-3-5-6/h1-5H,(H,11,12)(H2,9,13,14) AYAZOMSTWAJWHN-UHFFFAOYSA-N 50256515 CHEMBL475776::N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide Carbonic anhydrase 4 Homo sapiens 5540 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256515&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44571849 104107973 CHEMBL475776 ZINC40918571 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878383 COc1ccc(cc1)-c1nnc(NS(N)(=O)=O)s1 InChI=1S/C9H10N4O3S2/c1-16-7-4-2-6(3-5-7)8-11-12-9(17-8)13-18(10,14)15/h2-5H,1H3,(H,12,13)(H2,10,14,15) QSHUVOXSBUMLSD-UHFFFAOYSA-N 50256516 CHEMBL443769::N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]sulfamide Carbonic anhydrase 4 Homo sapiens 8760 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256516&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25154732 104107974 CHEMBL443769 ZINC40827889 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878384 NS(=O)(=O)Nc1nnc(s1)-c1ccc(Br)cc1 InChI=1S/C8H7BrN4O2S2/c9-6-3-1-5(2-4-6)7-11-12-8(16-7)13-17(10,14)15/h1-4H,(H,12,13)(H2,10,14,15) VSZGEYZPVJRSPX-UHFFFAOYSA-N 50256567 CHEMBL482149::N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]sulfamide Carbonic anhydrase 4 Homo sapiens 10050 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256567&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25154741 104108002 CHEMBL482149 ZINC40936427 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878385 CS(=O)(=O)c1nnc(NS(N)(=O)=O)s1 InChI=1S/C3H6N4O4S3/c1-13(8,9)3-6-5-2(12-3)7-14(4,10)11/h1H3,(H,5,7)(H2,4,10,11) JWUGIVSQNVELBH-UHFFFAOYSA-N 50256568 CHEMBL482150::N-[5-(methylsulfonyl)-1,3,4-thiadiazol-2-yl]sulfamide Carbonic anhydrase 4 Homo sapiens 6100 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256568&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44571892 104108003 CHEMBL482150 ZINC40936429 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50878431 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2008.10.093 10.7270/Q26T0NK7 18990571 Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Ecole Nationale Sup£rieure de Chimie de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50879847 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2009.01.038 10.7270/Q2JW8FS8 19186056 Crocetti, L; Maresca, A; Temperini, C; Hall, RA; Scozzafava, A; Muhlschlegel, FA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50879848 CC(=O)N=c1sc(nn1C)S(N)(=O)=O InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) FLOSMHQXBMRNHR-UHFFFAOYSA-N 10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid_4100::sulfonamide 2 Carbonic anhydrase 4 Homo sapiens 6200 ChEMBL 10.1016/j.bmcl.2009.01.038 10.7270/Q2JW8FS8 19186056 Crocetti, L; Maresca, A; Temperini, C; Hall, RA; Scozzafava, A; Muhlschlegel, FA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10881&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search MZM 4K0Z,4YHA,5KU6,1BZM,5C8I,3DAZ,3DCS 4100 46511451 CHEMBL288100 6828 ZINC12503151 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50879849 CCOc1ccc2nc(sc2c1)S(N)(=O)=O InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) OUZWUKMCLIBBOG-UHFFFAOYSA-N 10882 6-ethoxy-1,3-benzothiazole-2-sulfonamide::CHEMBL18::Ethamide::Ethoxazolamide::Ethoxzolamide::Ethoxzolamide (EZA)::Ethoxzolamide, EZM::Sulfonamide, 3::US10172837, Ethoxyzolamide::sulfonamide 3 Carbonic anhydrase 4 Homo sapiens 93 ChEMBL 10.1016/j.bmcl.2009.01.038 10.7270/Q2JW8FS8 19186056 Crocetti, L; Maresca, A; Temperini, C; Hall, RA; Scozzafava, A; Muhlschlegel, FA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10882&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EZL 3DD0,5JN9,3CAJ,3MDZ,6BCC,3DCW,6QL2,5TT3,6MWI 3295 46511452 101096 CHEMBL18 DB00311 6814 ZINC00056721 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50879850 NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1)S(N)(=O)=O InChI=1S/C15H14N4O3S/c16-19-15(20)14-13(9-4-2-1-3-5-9)11-8-10(23(17,21)22)6-7-12(11)18-14/h1-8,18H,16H2,(H,19,20)(H2,17,21,22) PPDLAUCFAOODER-UHFFFAOYSA-N 25904 2-(hydrazinecarbonyl)-3-phenyl-1H-indole-5-sulfonamide::BMC173212 Compound 1::CHEMBL262628::indole sulfonamide, L Carbonic anhydrase 4 Homo sapiens 9000 ChEMBL 10.1016/j.bmcl.2009.01.038 10.7270/Q2JW8FS8 19186056 Crocetti, L; Maresca, A; Temperini, C; Hall, RA; Scozzafava, A; Muhlschlegel, FA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25904&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TUO 3B4F 14611919 56413192 CHEMBL262628 DB08659 ZINC24959962 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50879851 NS(=O)(=O)c1ccc2nc([nH]c2c1)-c1cscn1 InChI=1S/C10H8N4O2S2/c11-18(15,16)6-1-2-7-8(3-6)14-10(13-7)9-4-17-5-12-9/h1-5H,(H,13,14)(H2,11,15,16) KGMVTZZDGKDTEU-UHFFFAOYSA-N 50248167 2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamide::2-(thiazol-4-yl)-1H-benzo[d]imidazole-5-sulfonamide::CHEMBL455271 Carbonic anhydrase 4 Homo sapiens 48.9 ChEMBL 10.1016/j.bmcl.2009.01.038 10.7270/Q2JW8FS8 19186056 Crocetti, L; Maresca, A; Temperini, C; Hall, RA; Scozzafava, A; Muhlschlegel, FA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248167&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search LC1 3FFP 44144383 104102877 CHEMBL455271 ZINC39716428 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50916438 Nc1nnc(s1)S(N)(=O)=O InChI=1S/C2H4N4O2S2/c3-1-5-6-2(9-1)10(4,7)8/h(H2,3,5)(H2,4,7,8) VGMVBPQOACUDRU-UHFFFAOYSA-N 10868 1,3,4-Thiadiazole-2-sulfonamide, 6::1,3,4-thiadiazole-2-sulfonamide 15::5-Amino-1,3,4-thiadiazole-2-sulphonamide (1)::5-amino-1,3,4-thiadiazole-2-sulfonamide::CHEMBL265674::aromatic/heteroaromatic sulfonamide 13 Carbonic anhydrase 4 Homo sapiens 940 ChEMBL 10.1016/j.bmcl.2010.06.082 10.7270/Q2C24XCB 20605094 Avvaru, BS; Wagner, JM; Maresca, A; Scozzafava, A; Robbins, AH; Supuran, CT; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10868&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1SA 2HNC,5TUO 84724 46509349 CHEMBL265674 ZINC16969869 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50916439 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2010.06.082 10.7270/Q2C24XCB 20605094 Avvaru, BS; Wagner, JM; Maresca, A; Scozzafava, A; Robbins, AH; Supuran, CT; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50916440 Nc1c(F)cc(cc1Cl)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C8H7ClFN5O4S3/c9-4-1-3(2-5(10)6(4)11)22(18,19)15-7-13-14-8(20-7)21(12,16)17/h1-2H,11H2,(H,13,15)(H2,12,16,17) HOLJYLOVIHBQHO-UHFFFAOYSA-N 11625 2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiadiazole-2,5-disulfonamide::5-{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide::CHEMBL71611::aminobenzolamide 18 Carbonic anhydrase 4 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2010.06.082 10.7270/Q2C24XCB 20605094 Avvaru, BS; Wagner, JM; Maresca, A; Scozzafava, A; Robbins, AH; Supuran, CT; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11625&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1CN 2HOC 11069133 46512148 CHEMBL71611 DB06891 ZINC13520197 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50916441 NS(=O)(=O)c1nnc(NC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)s1 InChI=1S/C13H18N4O3S2/c14-22(19,20)12-17-16-11(21-12)15-10(18)13-4-7-1-8(5-13)3-9(2-7)6-13/h7-9H,1-6H2,(H2,14,19,20)(H,15,16,18)/t7-,8+,9-,13? NBKDQESIWDNDOT-BQHQMIMCSA-N 50108563 Adamantane-1-carboxylic acid (5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-amide::CHEMBL108971 Carbonic anhydrase 4 Homo sapiens 349 ChEMBL 10.1016/j.bmcl.2010.06.082 10.7270/Q2C24XCB 20605094 Avvaru, BS; Wagner, JM; Maresca, A; Scozzafava, A; Robbins, AH; Supuran, CT; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50108563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50108563&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 394897 104003781 CHEMBL108971 ZINC05839050 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50916442 NS(=O)(=O)c1nnc(NC(=O)CC23CC4CC(CC(C4)C2)C3)s1 InChI=1S/C14H20N4O3S2/c15-23(20,21)13-18-17-12(22-13)16-11(19)7-14-4-8-1-9(5-14)3-10(2-8)6-14/h8-10H,1-7H2,(H2,15,20,21)(H,16,17,19) PBFBMBQOJPVXHB-UHFFFAOYSA-N 50323341 CHEMBL1209039 Carbonic anhydrase 4 Homo sapiens 413 ChEMBL 10.1016/j.bmcl.2010.06.082 10.7270/Q2C24XCB 20605094 Avvaru, BS; Wagner, JM; Maresca, A; Scozzafava, A; Robbins, AH; Supuran, CT; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323341&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46911381 117644662 CHEMBL1209039 ZINC58540717 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50916443 Cc1cc(C)[n+](CCc2ccc(cc2)S(N)(=O)=O)c(C)c1 InChI=1S/C16H21N2O2S/c1-12-10-13(2)18(14(3)11-12)9-8-15-4-6-16(7-5-15)21(17,19)20/h4-7,10-11H,8-9H2,1-3H3,(H2,17,19,20)/q+1 UXBCHTZINZNVRG-UHFFFAOYSA-N 11641 1-N-(4-sulfamoylphenyl-ethyl)-2,4,6-trimethylpyridiniumperchlorate::2,4,6-trimethyl-1-[2-(4-sulfamoylphenyl)ethyl]pyridin-1-ium perchlorate::CHEMBL352535::Compound 10::pyridinium deriv. 10 Carbonic anhydrase 4 Homo sapiens 60 ChEMBL 10.1016/j.bmcl.2010.06.082 10.7270/Q2C24XCB 20605094 Avvaru, BS; Wagner, JM; Maresca, A; Scozzafava, A; Robbins, AH; Supuran, CT; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11641&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PIU 1ZE8 5289159 46512164 CHEMBL352535 DB04763 ZINC12504500 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50916444 Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) RZEKVGVHFLEQIL-UHFFFAOYSA-N 11639 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide::CHEMBL118::CLX::Celebrex::Celecoxib::US10322118, Urea-Based Scaffold Entry 9::US11478464, Compound Celecoxib::US8741944, Comparative Compound::US9388139, Celecoxib::cid_2662 Carbonic anhydrase 4 Homo sapiens 880 ChEMBL 10.1016/j.bmcl.2010.06.082 10.7270/Q2C24XCB 20605094 Avvaru, BS; Wagner, JM; Maresca, A; Scozzafava, A; Robbins, AH; Supuran, CT; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11639&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CEL 3LN1,3KK6,5JW1,7ZEJ,4FIM,1OQ5 2662 46512162 41423 CHEMBL118 DB00482 2892 C07589 ZINC02570895 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50905604 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 IAVUPMFITXYVAF-XPUUQOCRSA-N 10884 (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide::Dorzolamide (DRZ)::Dorzolamide (DZA) Carbonic anhydrase 4 Homo sapiens 43 ChEMBL 10.1016/j.bmcl.2009.10.036 10.7270/Q2X92C80 19854054 Steele, RM; Benedini, F; Biondi, S; Borghi, V; Carzaniga, L; Impagnatiello, F; Miglietta, D; Chong, WK; Rajapakse, R; Cecchi, A; Temperini, C; Supuran, CT NicOx Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10884&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ETS 4M2W,4M2U,4K13,3FW3,6BC9,1CIL 5284549 46511454 4702 DB00869 6810 C06969 ZINC01530621 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50905605 CCN([C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O)C(=O)CCCCCO[N+]([O-])=O InChI=1S/C16H25N3O8S3/c1-3-18(14(20)7-5-4-6-8-27-19(21)22)13-9-11(2)29(23,24)16-12(13)10-15(28-16)30(17,25)26/h10-11,13H,3-9H2,1-2H3,(H2,17,25,26)/t11-,13-/m0/s1 NURFQAXKIXSLRE-AAEUAGOBSA-N 50303030 6-Nitrooxy-hexanoic acid ethyl-((4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-4-yl)-amide::CHEMBL568854 Carbonic anhydrase 4 Homo sapiens 4360 ChEMBL 10.1016/j.bmcl.2009.10.036 10.7270/Q2X92C80 19854054 Steele, RM; Benedini, F; Biondi, S; Borghi, V; Carzaniga, L; Impagnatiello, F; Miglietta, D; Chong, WK; Rajapakse, R; Cecchi, A; Temperini, C; Supuran, CT NicOx Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303030&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 45375967 104157391 CHEMBL568854 ZINC45259054 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50905606 CCN([C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O)C(=O)c1ccc(CO[N+]([O-])=O)cc1 InChI=1S/C18H21N3O8S3/c1-3-20(17(22)13-6-4-12(5-7-13)10-29-21(23)24)15-8-11(2)31(25,26)18-14(15)9-16(30-18)32(19,27)28/h4-7,9,11,15H,3,8,10H2,1-2H3,(H2,19,27,28)/t11-,15-/m0/s1 MGYQOULZLCGAGW-NHYWBVRUSA-N 50303031 CHEMBL570894::N-Ethyl-N-((4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-4-yl)-4-nitrooxymethyl-benzamide Carbonic anhydrase 4 Homo sapiens 46 ChEMBL 10.1016/j.bmcl.2009.10.036 10.7270/Q2X92C80 19854054 Steele, RM; Benedini, F; Biondi, S; Borghi, V; Carzaniga, L; Impagnatiello, F; Miglietta, D; Chong, WK; Rajapakse, R; Cecchi, A; Temperini, C; Supuran, CT NicOx Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303031&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 45486144 104157392 CHEMBL570894 ZINC45257532 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50905607 CCN([C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O)C(=O)OCCCO[N+]([O-])=O InChI=1S/C14H21N3O9S3/c1-3-16(14(18)25-5-4-6-26-17(19)20)11-7-9(2)28(21,22)13-10(11)8-12(27-13)29(15,23)24/h8-9,11H,3-7H2,1-2H3,(H2,15,23,24)/t9-,11-/m0/s1 WMNLMYBKRKWSIH-ONGXEEELSA-N 50303032 CHEMBL584939::Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-4-yl)-carbamic acid 3-nitrooxy-propyl ester Carbonic anhydrase 4 Homo sapiens 181 ChEMBL 10.1016/j.bmcl.2009.10.036 10.7270/Q2X92C80 19854054 Steele, RM; Benedini, F; Biondi, S; Borghi, V; Carzaniga, L; Impagnatiello, F; Miglietta, D; Chong, WK; Rajapakse, R; Cecchi, A; Temperini, C; Supuran, CT NicOx Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303032&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 45375968 104157393 CHEMBL584939 ZINC45319137 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50905608 CCN([C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O)C(=O)OCCCCO[N+]([O-])=O InChI=1S/C15H23N3O9S3/c1-3-17(15(19)26-6-4-5-7-27-18(20)21)12-8-10(2)29(22,23)14-11(12)9-13(28-14)30(16,24)25/h9-10,12H,3-8H2,1-2H3,(H2,16,24,25)/t10-,12-/m0/s1 QKMYYRKWTLURAF-JQWIXIFHSA-N 50303033 CHEMBL585756::Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-4-yl)-carbamic acid 4-nitrooxy-butyl ester Carbonic anhydrase 4 Homo sapiens 339 ChEMBL 10.1016/j.bmcl.2009.10.036 10.7270/Q2X92C80 19854054 Steele, RM; Benedini, F; Biondi, S; Borghi, V; Carzaniga, L; Impagnatiello, F; Miglietta, D; Chong, WK; Rajapakse, R; Cecchi, A; Temperini, C; Supuran, CT NicOx Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303033&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 45486167 104157394 CHEMBL585756 ZINC45324365 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50905609 CCN([C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O)C(=O)OCC(CO[N+]([O-])=O)O[N+]([O-])=O InChI=1S/C14H20N4O12S3/c1-3-16(14(19)28-6-9(30-18(22)23)7-29-17(20)21)11-4-8(2)32(24,25)13-10(11)5-12(31-13)33(15,26)27/h5,8-9,11H,3-4,6-7H2,1-2H3,(H2,15,26,27)/t8-,9?,11-/m0/s1 RFISBOUXKIOATP-QCZWPSDZSA-N 50303034 CHEMBL571337::Ethyl-((4S,6S)-6-methyl-7,7-dioxo-2-sulfamoyl-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-4-yl)-carbamic acid 2,3-bis-nitrooxy-propyl ester Carbonic anhydrase 4 Homo sapiens 3905 ChEMBL 10.1016/j.bmcl.2009.10.036 10.7270/Q2X92C80 19854054 Steele, RM; Benedini, F; Biondi, S; Borghi, V; Carzaniga, L; Impagnatiello, F; Miglietta, D; Chong, WK; Rajapakse, R; Cecchi, A; Temperini, C; Supuran, CT NicOx Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303034&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 45375973 104157395 CHEMBL571337 ZINC49694633 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912117 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 IAVUPMFITXYVAF-XPUUQOCRSA-N 10884 (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide::Dorzolamide (DRZ)::Dorzolamide (DZA) Carbonic anhydrase 4 Homo sapiens 43 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10884&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ETS 4M2W,4M2U,4K13,3FW3,6BC9,1CIL 5284549 46511454 4702 DB00869 6810 C06969 ZINC01530621 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912129 NS(=O)(=O)c1ccc(Oc2ccccc2)c(c1)C(=O)NCc1ccccc1 InChI=1S/C20H18N2O4S/c21-27(24,25)17-11-12-19(26-16-9-5-2-6-10-16)18(13-17)20(23)22-14-15-7-3-1-4-8-15/h1-13H,14H2,(H,22,23)(H2,21,24,25) RVAUZMFMCLNUET-UHFFFAOYSA-N 50317388 5-(Aminosulfonyl)-N-benzyl-2-phenoxybenzamide::CHEMBL1098205 Carbonic anhydrase 4 Homo sapiens 2040 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317388&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46887936 104151749 CHEMBL1098205 ZINC49784580 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912130 NS(=O)(=O)c1ccc(SCc2ccccc2)c(c1)C(=O)NCc1ccccc1 InChI=1S/C21H20N2O3S2/c22-28(25,26)18-11-12-20(27-15-17-9-5-2-6-10-17)19(13-18)21(24)23-14-16-7-3-1-4-8-16/h1-13H,14-15H2,(H,23,24)(H2,22,25,26) UWXYGZQIRPAISJ-UHFFFAOYSA-N 50317389 5-(Aminosulfonyl)-N-benzyl-2-(benzylthio)benzamide::CHEMBL1098206 Carbonic anhydrase 4 Homo sapiens 1480 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317389&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46887937 104151750 CHEMBL1098206 ZINC49784581 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912131 NS(=O)(=O)c1ccc(Sc2ccccc2CO)c(c1)C(=O)NCc1ccccn1 InChI=1S/C20H19N3O4S2/c21-29(26,27)16-8-9-19(28-18-7-2-1-5-14(18)13-24)17(11-16)20(25)23-12-15-6-3-4-10-22-15/h1-11,24H,12-13H2,(H,23,25)(H2,21,26,27) INKDVZGBNWJINE-UHFFFAOYSA-N 50317390 5-(Aminosulfonyl)-2-{[2-(hydroxymethyl)phenyl]thio}-N-(pyridin-2-ylmethyl)benzamide::CHEMBL1098207 Carbonic anhydrase 4 Homo sapiens 952 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317390&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46887938 104151751 CHEMBL1098207 ZINC49115783 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912132 NS(=O)(=O)c1ccc(Sc2ccccn2)c(c1)C(=O)NCc1ccccn1 InChI=1S/C18H16N4O3S2/c19-27(24,25)14-7-8-16(26-17-6-2-4-10-21-17)15(11-14)18(23)22-12-13-5-1-3-9-20-13/h1-11H,12H2,(H,22,23)(H2,19,24,25) FQUCBGMMKAOFQC-UHFFFAOYSA-N 50317391 5-(Aminosulfonyl)-N-(pyridin-2-ylmethyl)-2-(pyridin-2-ylthio)benzamide::CHEMBL1098208 Carbonic anhydrase 4 Homo sapiens >5000 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317391&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46887939 104151752 CHEMBL1098208 ZINC49089895 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912133 NS(=O)(=O)c1ccc(Sc2ccccc2)c(c1)C(=O)NCc1ccccn1 InChI=1S/C19H17N3O3S2/c20-27(24,25)16-9-10-18(26-15-7-2-1-3-8-15)17(12-16)19(23)22-13-14-6-4-5-11-21-14/h1-12H,13H2,(H,22,23)(H2,20,24,25) BXTHWNJLGBFQMW-UHFFFAOYSA-N 50317392 5-(Aminosulfonyl)-2-(phenylthio)-N-(pyridin-2-ylmethyl)benzamide::CHEMBL1096820 Carbonic anhydrase 4 Homo sapiens 783 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317392&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46887969 104151753 CHEMBL1096820 ZINC49112973 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912134 COCCNC(=O)c1cc(ccc1SCCc1ccccc1)S(N)(=O)=O InChI=1S/C18H22N2O4S2/c1-24-11-10-20-18(21)16-13-15(26(19,22)23)7-8-17(16)25-12-9-14-5-3-2-4-6-14/h2-8,13H,9-12H2,1H3,(H,20,21)(H2,19,22,23) MBXJFMPDXDLKOS-UHFFFAOYSA-N 50317393 5-(Aminosulfonyl)-N-(2-methoxyethyl)-2-[(2-phenylethyl)thio]benzamide::CHEMBL1096821 Carbonic anhydrase 4 Homo sapiens 1910 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317393&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46887970 104151754 CHEMBL1096821 ZINC49784979 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912135 CC(C)CNC(=O)c1cc(ccc1SC(C)C)S(N)(=O)=O InChI=1S/C14H22N2O3S2/c1-9(2)8-16-14(17)12-7-11(21(15,18)19)5-6-13(12)20-10(3)4/h5-7,9-10H,8H2,1-4H3,(H,16,17)(H2,15,18,19) RGQAMWOBJSCLAA-UHFFFAOYSA-N 50317394 5-(Aminosulfonyl)-N-isobutyl-2-(isopropylthio)benzamide::CHEMBL1096822 Carbonic anhydrase 4 Homo sapiens >5000 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317394&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46887971 104151755 CHEMBL1096822 ZINC49784884 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912136 CCNC(=O)c1cc(ccc1SC1CCCC1)S(N)(=O)=O InChI=1S/C14H20N2O3S2/c1-2-16-14(17)12-9-11(21(15,18)19)7-8-13(12)20-10-5-3-4-6-10/h7-10H,2-6H2,1H3,(H,16,17)(H2,15,18,19) REHYANQPPHOBGY-UHFFFAOYSA-N 50317395 5-(Aminosulfonyl)-2-(cyclopentylthio)-N-ethylbenzamide::CHEMBL1096823 Carbonic anhydrase 4 Homo sapiens >5000 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317395&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46887972 104151756 CHEMBL1096823 ZINC49784980 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912137 NS(=O)(=O)c1ccc(c(c1)C(=O)NCc1ccccc1)S(=O)(=O)c1ccccc1 InChI=1S/C20H18N2O5S2/c21-29(26,27)17-11-12-19(28(24,25)16-9-5-2-6-10-16)18(13-17)20(23)22-14-15-7-3-1-4-8-15/h1-13H,14H2,(H,22,23)(H2,21,26,27) ZULOSPOKQJSTNL-UHFFFAOYSA-N 50317396 5-(Aminosulfonyl)-N-benzyl-2-(phenylsulfonyl)benzamide::CHEMBL1098526 Carbonic anhydrase 4 Homo sapiens 1450 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317396&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46887973 104151757 CHEMBL1098526 ZINC49089425 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912138 CCNC(=O)c1cc(cnc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C14H15N3O3S2/c1-2-16-13(18)12-8-11(22(15,19)20)9-17-14(12)21-10-6-4-3-5-7-10/h3-9H,2H2,1H3,(H,16,18)(H2,15,19,20) PWAINXTYUTUOAR-UHFFFAOYSA-N 50317397 5-(Aminosulfonyl)-N-ethyl-2-(phenylthio)nicotinamide::CHEMBL1086703 Carbonic anhydrase 4 Homo sapiens 283 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317397&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46887974 104151758 CHEMBL1086703 ZINC49054020 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912139 CN(C)CCNC(=O)c1cc(cnc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C16H20N4O3S2/c1-20(2)9-8-18-15(21)14-10-13(25(17,22)23)11-19-16(14)24-12-6-4-3-5-7-12/h3-7,10-11H,8-9H2,1-2H3,(H,18,21)(H2,17,22,23) UXOSWFONJFRLHU-UHFFFAOYSA-N 50317398 5-(Aminosulfonyl)-N-[2-(dimethylamino)ethyl]-2-(phenyl-thio)nicotinamide::CHEMBL1098816 Carbonic anhydrase 4 Homo sapiens >5000 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317398&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888010 104151759 CHEMBL1098816 ZINC49089539 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912140 COCCNC(=O)c1cc(cnc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C15H17N3O4S2/c1-22-8-7-17-14(19)13-9-12(24(16,20)21)10-18-15(13)23-11-5-3-2-4-6-11/h2-6,9-10H,7-8H2,1H3,(H,17,19)(H2,16,20,21) VBOBKHQNIYRRAK-UHFFFAOYSA-N 50317399 5-(Aminosulfonyl)-N-(2-methoxyethyl)-2-(phenylthio)-nicotinamide::CHEMBL1098817 Carbonic anhydrase 4 Homo sapiens 361 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317399&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888011 104151760 CHEMBL1098817 ZINC49089553 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912141 COCCCNC(=O)c1cc(cnc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C16H19N3O4S2/c1-23-9-5-8-18-15(20)14-10-13(25(17,21)22)11-19-16(14)24-12-6-3-2-4-7-12/h2-4,6-7,10-11H,5,8-9H2,1H3,(H,18,20)(H2,17,21,22) YFGZGDDAWQULRR-UHFFFAOYSA-N 50317400 5-(Aminosulfonyl)-N-(3-methoxypropyl)-2-(phenylthio)-nicotinamide::CHEMBL1099124::N-(3-methoxypropyl)-2-(phenylsulfanyl)-5-sulfamoylpyridine-3-carboxamide Carbonic anhydrase 4 Homo sapiens 246 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317400&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AG4 3F7U 44201383 104151761 CHEMBL1099124 ZINC49114129 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912142 CCCNC(=O)c1cc(cnc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C15H17N3O3S2/c1-2-8-17-14(19)13-9-12(23(16,20)21)10-18-15(13)22-11-6-4-3-5-7-11/h3-7,9-10H,2,8H2,1H3,(H,17,19)(H2,16,20,21) VMQRRWYNFJEGEJ-UHFFFAOYSA-N 50317401 5-(Aminosulfonyl)-2-(phenylthio)-N-propylnicotinamide::CHEMBL1099125 Carbonic anhydrase 4 Homo sapiens 229 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317401&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888012 104151762 CHEMBL1099125 ZINC49089556 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912143 NS(=O)(=O)c1cnc(Sc2ccccc2)c(c1)C(=O)NCCc1ccccc1 InChI=1S/C20H19N3O3S2/c21-28(25,26)17-13-18(19(24)22-12-11-15-7-3-1-4-8-15)20(23-14-17)27-16-9-5-2-6-10-16/h1-10,13-14H,11-12H2,(H,22,24)(H2,21,25,26) MGWPMEUXUFQQAQ-UHFFFAOYSA-N 50317402 5-(Aminosulfonyl)-N-(2-phenylethyl)-2-(phenylthio)-nicotinamide::CHEMBL1094898::N-(2-phenylethyl)-2-(phenylsulfanyl)-5-sulfamoylpyridine-3-carboxamide Carbonic anhydrase 4 Homo sapiens 64 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317402&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AG5 3F7B 44201382 104151763 CHEMBL1094898 ZINC39716028 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912144 NS(=O)(=O)c1cnc(Sc2c(F)c(F)cc(F)c2F)c(c1)C(=O)NCc1ccccn1 InChI=1S/C18H12F4N4O3S2/c19-12-6-13(20)15(22)16(14(12)21)30-18-11(5-10(8-26-18)31(23,28)29)17(27)25-7-9-3-1-2-4-24-9/h1-6,8H,7H2,(H,25,27)(H2,23,28,29) UCCQGLWDGDGAGF-UHFFFAOYSA-N 50317403 5-(Aminosulfonyl)-N-(pyridin-2-ylmethyl)-2-[(2,3,5,6-tetrafluorophenyl)thio]nicotinamide::CHEMBL1098839 Carbonic anhydrase 4 Homo sapiens 23 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317403&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888057 104151764 CHEMBL1098839 ZINC49088375 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912167 NS(=O)(=O)c1ccc(Sc2ccccc2)c(c1)C(=O)NCc1ccccc1 InChI=1S/C20H18N2O3S2/c21-27(24,25)17-11-12-19(26-16-9-5-2-6-10-16)18(13-17)20(23)22-14-15-7-3-1-4-8-15/h1-13H,14H2,(H,22,23)(H2,21,24,25) HTNHJMAIMHUHEK-UHFFFAOYSA-N 50317386 5-(Aminosulfonyl)-N-benzyl-2-(phenylthio)benzamide::CHEMBL1098496 Carbonic anhydrase 4 Homo sapiens 241 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317386&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46887904 104151747 CHEMBL1098496 ZINC49124658 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912168 CCNC(=O)c1cc(ccc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C15H16N2O3S2/c1-2-17-15(18)13-10-12(22(16,19)20)8-9-14(13)21-11-6-4-3-5-7-11/h3-10H,2H2,1H3,(H,17,18)(H2,16,19,20) FNYVAHRKYCCQJY-UHFFFAOYSA-N 50317387 5-(Aminosulfonyl)-N-ethyl-2-(phenylthio)benzamide::CHEMBL1098204 Carbonic anhydrase 4 Homo sapiens 575 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317387&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46887935 104151748 CHEMBL1098204 ZINC49115128 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912169 CCNC(=O)c1cc(cnc1Sc1cccc(F)c1)S(N)(=O)=O InChI=1S/C14H14FN3O3S2/c1-2-17-13(19)12-7-11(23(16,20)21)8-18-14(12)22-10-5-3-4-9(15)6-10/h3-8H,2H2,1H3,(H,17,19)(H2,16,20,21) AUKODXIXKPYFEV-UHFFFAOYSA-N 50317404 5-(Aminosulfonyl)-N-ethyl-2-[(3-fluorophenyl)thio]nicotinamide::CHEMBL1098349 Carbonic anhydrase 4 Homo sapiens 126 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317404&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888058 104151765 CHEMBL1098349 ZINC49125268 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912170 COc1ccc(CNC(=O)c2cc(cnc2Sc2ccc(F)c(F)c2)S(N)(=O)=O)cc1 InChI=1S/C20H17F2N3O4S2/c1-29-13-4-2-12(3-5-13)10-24-19(26)16-9-15(31(23,27)28)11-25-20(16)30-14-6-7-17(21)18(22)8-14/h2-9,11H,10H2,1H3,(H,24,26)(H2,23,27,28) LZNQOLHEWHQXON-UHFFFAOYSA-N 50317405 5-(Aminosulfonyl)-2-[(3,4-difluorophenyl)thio]-N-(4-methoxybenzyl)nicotinamide::CHEMBL1095203 Carbonic anhydrase 4 Homo sapiens 46.8 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317405&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888059 104151766 CHEMBL1095203 ZINC49071645 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912171 COCCCNC(=O)c1cc(cnc1Sc1cccc(F)c1)S(N)(=O)=O InChI=1S/C16H18FN3O4S2/c1-24-7-3-6-19-15(21)14-9-13(26(18,22)23)10-20-16(14)25-12-5-2-4-11(17)8-12/h2,4-5,8-10H,3,6-7H2,1H3,(H,19,21)(H2,18,22,23) CTPNBKNKDDNPCB-UHFFFAOYSA-N 50317406 5-(Aminosulfonyl)-N-(3-methoxypropyl)-2-[(3-fluorophe-nyl)thio]nicotinamide::CHEMBL1095204 Carbonic anhydrase 4 Homo sapiens 118 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317406&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888060 104151767 CHEMBL1095204 ZINC49110970 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912172 COCCCNC(=O)c1cc(cnc1Sc1c(F)c(F)cc(F)c1F)S(N)(=O)=O InChI=1S/C16H15F4N3O4S2/c1-27-4-2-3-22-15(24)9-5-8(29(21,25)26)7-23-16(9)28-14-12(19)10(17)6-11(18)13(14)20/h5-7H,2-4H2,1H3,(H,22,24)(H2,21,25,26) VGMNBWJHGVEWGS-UHFFFAOYSA-N 50317407 5-(Aminosulfonyl)-N-(3-methoxypropyl)-2-[(2,3,5,6-tetrafluorophenyl)thio]nicotinamide::CHEMBL1099137 Carbonic anhydrase 4 Homo sapiens 23 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317407&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888061 104151768 CHEMBL1099137 ZINC49089557 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912173 COCCCNC(=O)c1cc(cnc1Sc1ccc(F)c(F)c1)S(N)(=O)=O InChI=1S/C16H17F2N3O4S2/c1-25-6-2-5-20-15(22)12-8-11(27(19,23)24)9-21-16(12)26-10-3-4-13(17)14(18)7-10/h3-4,7-9H,2,5-6H2,1H3,(H,20,22)(H2,19,23,24) UMCSMCWCGKGVAL-UHFFFAOYSA-N 50317408 5-(Aminosulfonyl)-2-[(3,4-difluorophenyl)thio]-N-(3-methoxypropyl)nicotinamide::CHEMBL1086834 Carbonic anhydrase 4 Homo sapiens 139 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317408&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888093 104151769 CHEMBL1086834 ZINC49113770 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912174 NS(=O)(=O)c1ccc(Sc2c(F)c(F)cc(F)c2F)c(c1)C(=O)NCCc1ccccn1 InChI=1S/C20H15F4N3O3S2/c21-14-10-15(22)18(24)19(17(14)23)31-16-5-4-12(32(25,29)30)9-13(16)20(28)27-8-6-11-3-1-2-7-26-11/h1-5,7,9-10H,6,8H2,(H,27,28)(H2,25,29,30) DNLAXQXZFNLJHG-UHFFFAOYSA-N 50317409 5-(Aminosulfonyl)-N-(2-pyridin-2-ylethyl)-2-[(2,3,5,6-tetrafluorophenyl)thio]nicotinamide::CHEMBL1095531 Carbonic anhydrase 4 Homo sapiens 20.9 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317409&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888094 104151770 CHEMBL1095531 ZINC49087555 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912175 NCCCCNC(=O)c1cc(cnc1Sc1c(F)c(F)cc(F)c1F)S(N)(=O)=O InChI=1S/C16H16F4N4O3S2/c17-10-6-11(18)13(20)14(12(10)19)28-16-9(15(25)23-4-2-1-3-21)5-8(7-24-16)29(22,26)27/h5-7H,1-4,21H2,(H,23,25)(H2,22,26,27) QGHOBAGZKQWLLO-UHFFFAOYSA-N 50317410 CHEMBL1099151::N-(3-Aminopropyl)-5-(aminosulfonyl)-2-[(2,3,5,6-tetrafluorophenyl)thio]nicotinamide Carbonic anhydrase 4 Homo sapiens 33.1 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317410&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46861804 104151771 CHEMBL1099151 ZINC49089466 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912176 COc1ccc(CCCNC(=O)c2cc(cnc2Sc2c(F)c(F)cc(F)c2F)S(N)(=O)=O)cc1 InChI=1S/C22H19F4N3O4S2/c1-33-13-6-4-12(5-7-13)3-2-8-28-21(30)15-9-14(35(27,31)32)11-29-22(15)34-20-18(25)16(23)10-17(24)19(20)26/h4-7,9-11H,2-3,8H2,1H3,(H,28,30)(H2,27,31,32) LQGBGIQOCRJGKR-UHFFFAOYSA-N 50317411 5-(Aminosulfonyl)-N-[2-(4-methoxyphenyl)ethyl]-2-[(2,3,5,6-tetrafluorophenyl)thio]nicotinamide::CHEMBL1099152 Carbonic anhydrase 4 Homo sapiens 23 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317411&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888095 104151772 CHEMBL1099152 ZINC49785583 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912177 NS(=O)(=O)c1cnc(Sc2ccc(F)c(F)c2)c(CO)c1 InChI=1S/C12H10F2N2O3S2/c13-10-2-1-8(4-11(10)14)20-12-7(6-17)3-9(5-16-12)21(15,18)19/h1-5,17H,6H2,(H2,15,18,19) CRFZOUPYNGVSGE-UHFFFAOYSA-N 50317412 6-[(3,4-Difluorophenyl)thio]-5-(hydroxymethyl)-pyridine-3-sulfonamide::CHEMBL1098657 Carbonic anhydrase 4 Homo sapiens 1230 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317412&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888096 104151773 CHEMBL1098657 ZINC49089445 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912178 COc1ccc(CNCc2cc(cnc2Sc2ccc(F)c(F)c2)S(N)(=O)=O)cc1 InChI=1S/C20H19F2N3O3S2/c1-28-15-4-2-13(3-5-15)10-24-11-14-8-17(30(23,26)27)12-25-20(14)29-16-6-7-18(21)19(22)9-16/h2-9,12,24H,10-11H2,1H3,(H2,23,26,27) ZCPIQKOKNVQSDL-UHFFFAOYSA-N 50317413 6-[(3,4-Difluorophenyl)thio]-5-{[(4-methoxybenzyl)-amino]methyl}pyridine-3-sulfonamide::CHEMBL1095855 Carbonic anhydrase 4 Homo sapiens 402 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317413&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888136 104151774 CHEMBL1095855 ZINC49114465 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912179 CCNCc1cc(cnc1Sc1ccc(F)c(F)c1)S(N)(=O)=O InChI=1S/C14H15F2N3O2S2/c1-2-18-7-9-5-11(23(17,20)21)8-19-14(9)22-10-3-4-12(15)13(16)6-10/h3-6,8,18H,2,7H2,1H3,(H2,17,20,21) GXDPLMDIWGKEAT-UHFFFAOYSA-N 50317414 6-[(3,4-Difluorophenyl)thio]-5-[(ethylamino)methyl]-pyridine-3-sulfonamide::CHEMBL1095856 Carbonic anhydrase 4 Homo sapiens 2660 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317414&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888137 104151775 CHEMBL1095856 ZINC49089545 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912180 COCCCNCc1cc(cnc1Sc1ccc(F)c(F)c1)S(N)(=O)=O InChI=1S/C16H19F2N3O3S2/c1-24-6-2-5-20-9-11-7-13(26(19,22)23)10-21-16(11)25-12-3-4-14(17)15(18)8-12/h3-4,7-8,10,20H,2,5-6,9H2,1H3,(H2,19,22,23) WRDOEWKDTJCVRO-UHFFFAOYSA-N 50317415 6-[(3,4-Difluorophenyl)thio]-5-{[(3-methoxypropyl)-amino]methyl}pyridine-3-sulfonamide::CHEMBL1095882 Carbonic anhydrase 4 Homo sapiens 2190 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317415&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888138 104151776 CHEMBL1095882 ZINC49112323 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912181 CCNC(=O)c1cc(cc(F)c1SC(C)C)S(N)(=O)=O InChI=1S/C12H17FN2O3S2/c1-4-15-12(16)9-5-8(20(14,17)18)6-10(13)11(9)19-7(2)3/h5-7H,4H2,1-3H3,(H,15,16)(H2,14,17,18) FGYBFQBXPZITQQ-UHFFFAOYSA-N 50317416 5-(Aminosulfonyl)-N-ethyl-3-fluoro-2-(isopropylthio)-benzamide::CHEMBL1099003 Carbonic anhydrase 4 Homo sapiens 1890 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317416&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46861805 104151777 CHEMBL1099003 ZINC49114382 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912182 CCNC(=O)c1cc(cc(F)c1SCC(C)C)S(N)(=O)=O InChI=1S/C13H19FN2O3S2/c1-4-16-13(17)10-5-9(21(15,18)19)6-11(14)12(10)20-7-8(2)3/h5-6,8H,4,7H2,1-3H3,(H,16,17)(H2,15,18,19) DHFAPSANOAWJDB-UHFFFAOYSA-N 50317417 5-(Aminosulfonyl)-N-ethyl-3-fluoro-2-(isobutylthio)-benzamide::CHEMBL1095883 Carbonic anhydrase 4 Homo sapiens 1250 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317417&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46888139 104151778 CHEMBL1095883 ZINC49088539 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50912183 NS(=O)(=O)c1ccc(Sc2c(F)c(F)cc(F)c2F)nc1 InChI=1S/C11H6F4N2O2S2/c12-6-3-7(13)10(15)11(9(6)14)20-8-2-1-5(4-17-8)21(16,18)19/h1-4H,(H2,16,18,19) VFNLQGFWLLNNHB-UHFFFAOYSA-N 50317418 6-[(2,3,5,6-Tetrafluorophenyl)thio]pyridine-3-sulfonamide::CHEMBL1095884 Carbonic anhydrase 4 Homo sapiens 188 ChEMBL 10.1016/j.bmc.2010.03.014 10.7270/Q2SQ91B9 20363633 Vernier, W; Chong, W; Rewolinski, D; Greasley, S; Pauly, T; Shaw, M; Dinh, D; Ferre, RA; Meador, JW; Nukui, S; Ornelas, M; Paz, RL; Reyner, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317418&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46861806 104151779 CHEMBL1095884 ZINC49088540 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50919436 NS(O)(=O)=O InChI=1S/H3NO3S/c1-5(2,3)4/h(H3,1,2,3,4) IIACRCGMVDHOTQ-UHFFFAOYSA-N 26994 CHEMBL68253::H2NSO3H::sulfamic acid Carbonic anhydrase 4 Homo sapiens 930 ChEMBL 10.1016/j.bmc.2010.12.033 10.7270/Q2ST7QT4 21211980 Ekinci, D; Ceyhun, SB; Senturk, M; Erdem, D; Kufrevioglu, OI; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26994&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5987 57298704 48266 CHEMBL68253 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50919437 [I-] InChI=1S/HI/h1H/p-1 XMBWDFGMSWQBCA-UHFFFAOYSA-M 26981 CHEMBL1644695::I-::POTASSIUM IODIDE::iodide::iodide ion Carbonic anhydrase 4 Homo sapiens 80000 ChEMBL 10.1016/j.bmc.2010.12.033 10.7270/Q2ST7QT4 21211980 Ekinci, D; Ceyhun, SB; Senturk, M; Erdem, D; Kufrevioglu, OI; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26981&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IDO 1ARX,1ARY,1B2K,1CMK,1CQW,1F09,1F3M,1GW9,1GWA,1GWD,1GWG,1GZA,1HC0,1HC9,1HUH,1J2J,1J99,1JWG,1LKR,1MOU,1MOV,1MXI,1N5M,1NJK,1NZB,1OJ5,1OUQ,1OVL,1OXS,1OXU,1OXV,1OXX,1PVH,1Q0T,1Q3U,1Q3V,1Q8C,1QI9,1QK0,1RLJ,1RRK,1RS0,1RTK,1S1M,1S6V,1SD5,1T1F,1T6C,1TUK,1U12,1U65,1UJK,1UTX,1V1F,1V1G,1VAT,1VKC,1VKO,1W2Z,1W50,1W51,1WC7,1WCB,1WCV,1WNW,1WY4,1XB7,1XC6,1XP4,1Y0S,1YDO,1YKU,1YRI,1ZCR,1ZVV,2A0N,2AF6,2AK4,2ANV,2ANX,2AQW,2ARL,2B9X,2BIV,2BMK,2C3N,2C3Q,2C3V,2CIW,2CJ6,2CJ7,2CJ8,2CKK,2CKL,2D8O,2D8P,2D8W,2D91,2D98,2DFB,2DFC,2DGM,2EDA,2EDC,2EIX,2ES4,2ESV,2EWJ,2FDS,2FWE,2FWF,2FWH,2GGQ,2GJM,2GQ2,2GS7,2GZB,2H9A,2HA0,2HA7,2HIB,2HQ6,2HRA,2I05,2I06,2I1W,2I8E,2ID1,2IPS,2IWK,2IZD,2IZQ,2J7P,2JJS,2NOO,2NQX,2O2B,2O86,2OF0,2OGS,2OGT,2OHK,2OHL,2OHM,2OHN,2OHP,2OHQ,2OHR,2OHS,2OHT,2OHU,2OJV,2OYY,2P4M,2PFI,2PUM,2Q2L,2QC5,2QCH,2QHX,2QPK,2QQT,2R5L,2REZ,2V8I,2VA5,2VA6,2VA7,2VBV,2VGZ,2VMA,2VUW,2YV7,2Z5Z,3BAS,3BCA,3BS9,3BV9,3CGP,3CJQ,3CT9,3D11,3DHX,3DY6,3E3T,3E7A,3EGV,3F6Q,3FNL 30165 57298691 64428 CHEMBL185537CHEMBL1644695 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50919438 [N-]=C=S InChI=1S/CNS/c2-1-3/q-1 ZBKFYXZXZJPWNQ-UHFFFAOYSA-N 26983 CHEMBL1644028::SCN(-1)::Thiocyanate::cyanosulfanide::sodium thiocyanate Carbonic anhydrase 4 Homo sapiens 39000000 ChEMBL 10.1016/j.bmc.2010.12.033 10.7270/Q2ST7QT4 21211980 Ekinci, D; Ceyhun, SB; Senturk, M; Erdem, D; Kufrevioglu, OI; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26983&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SCN 3B3C,3B3S,3B3V,3B3W,3B3T,3B35,1YLK,3GCL,3GCK,3GCJ,3GC1,4IMQ,4IMZ,4IMO,4YGK,1DNU,1DNW,5HNS,6QJU,5LIH,3VRK,6THV,2YOA,6JPT,2TCI,6LCO,3CQX,1KGS,6L9T,4RJD,2EHA,3ERA,3ERH,3ERI,5LE2,6KV0,3R15,4NPE,5JQ4,3CGM,2OLZ,6BTP,6BTQ,6BTO,6KY7,6YJI,3N8F,4NYW,2FA2,7QKN,4L82,3TGY,3ZXN,7U4I,7U4J,1GXW,2YAS,3N72,6D9N,2VR6,2VR7,2VR8,5QJ0,4A9K,2YLC,3QZ0,5VP3,2F49,4GV5,3BFF,3VH9,2EB5,2EB4,6D2J,6D2V,6DXX,5OLG,4JPS,3MNP,2WWP,3R5O,3R55,7Q4A,6EOL,6EOG,7Z0N,2PA5,1UTH,3S4F,7TOM,6H1F,4Z9S,5GLS,3TL2,6X94,2OM1,6BSL,4GM7,4WND,5N4I,1Y81,4ETQ,6A6Y,7B9C,7DE5,5OVV,3WAW,2UYE,2UYF,8BB2,8BB3,8BB5,4EB0,3GA5,6MAN,6GS3,2AV1,3CIX,6X8O,4MSF,2PUM,7O21,6YHQ,5OUF,2Y27,2RFL,3HUF,6XOC,6EVB,6EV8,6EV5,3O5O,3BXI,3BXH,4OD7,4R0Q,4NPD,4AUP,4V0C,4ZG6,4ZGA,6W35,5U28,7OIH,4KSZ,7RMS,4A6U,3UCM,7OQ6,2XES,5MZG,5KO0,7P4O,3BOS,5D3D,7TIA,7TIZ,5I83,4PDY,2A9V,5LSY,5LSR,5LSS,2PCU,2ABB,5OBW,5OBU,3Q85,6Y2H,4OEK,6A4Y,3HK0,3U65,7RMR,5HBB,6NWL,4UE0,4E7U,3NKN,3NKO,3NKM,3NKR,3NKP,3NKQ,5I86,6SSS,5EG8,6DU7,4A75,3UBA,7Z3L,7Z3K,1LCN,4HON,6EBX,6EBZ,4UMO,6CCF,3EVX,5YII,5MVV,2H11,5NHT,7ASZ,4FGE,4FGD,3LNY,5LT7,3DSO,3SXV,2A5V,3V6Q,7YZ8,6Y9C,3O71,5FYP,6ZJ7,6ZJ4,6FHN,2QRB,6J9J,1XPP,6RQX,7PB6,6E5B,5M7M,6MR1,1RTQ,5IJQ,2XR9,4ZAY,4ZAX,4ZAZ,4ZAW,4ZAV,4ZAL,4ZAN,4ZAG,4ZAF,5EUX,1TEW,4Y55,3FKJ,5JJY,6QZY,6LF7,5OHY,5OHS,5W53,3SE2,7VLJ,3C70,4XG1,3QF1,1LOK,7ARP,4AB1,3QK2,1SQ4,7QF6,4YB5,2RKY,7YYJ,4L37,2VXH,1BHC,2E9E,2CA2,4OCF,6WU5,4P0C,8ING,5O1X,5A13,7R58,6NUB,6NU5,5E2G,6TF7,6KFB,2WYK,6XPH,7BR1,3PVZ,3R4X,4Y7P,5W4M,2GJM,2WL1,6HAV,6HAE,2OGB,3ETW,3PY4,5K9H,2J51,6LDQ,6XFU,3B7I,4VHB,4QJQ,6U9L,1SP3,3FAQ,6R0K,2FNO,6RZJ,6RZI,6RZL,3V48,2IPS,1XQ9,3H8D,2QPK,3WAY,3WAX,4F36,7AHB,3LNX,6XSN,7OMY,7OMX,7OMZ,7OMW,7OMV,7OMF,5ULH,5LT6,4PCG,6P1E,2JLP,6L2J,7MSQ,6S0F,3IBD,7JTO,5LSZ,5LS7,7L8L,7L8R,6SJ9,2QQT,3FCL,3FCI,3FCF,7S7R,2EFB,7Q63,3I6N,2V51,4D7Z,1U4H,6VDB,5DLW,5DLV,5DLT,5DLB,6LK1,3NOF,3FNL,7ANU,4FUM,4FUO,4FUN,6B8W,5EBE,1LG6,6ZW1,5AE4,6SP8,6SP5,5V8G,3LY5,5TJ7,3KXL,3P1C,3P1D,3P1E,4CRZ,3H79,6XHT,6XHR,6XHS,7AWE,5FA2,7QL7,3BFE,2FAM,1H51,5NRK,6D1P,3EGR,7P0K,4F7O,7ZQX,5AQA,6TC2,7WYJ,4EFR,4EFQ,4EFP,3G5O,4HEI,7XXK,2JFL,7OO2,5ZGS,5M0D,5M0E,5M0M,3UEN,6M7E,5M0S,4PAB,4PAW,6FIE,5AQ8,7OXV,7KOV,1GMK,4CS0,1SXS,2GX9,3SRX,3VEH,1Y7H,3ZZO,6Y9D,4DO8,6I4K,6I4J,6I4I,6I4M,6I4L,6I4G,6I4E,6I4D,3KXI,6ZN1,4TSQ,3POX,3POQ,7PGE,2V3U,5MHP,2WUF,2WUG,2WUD,2WUE,3WAV,2JIL,4TXO,6B6U,6DS9,5K0P,6KUM,3I3N,7P4J,6FHC,3TJQ,5BU6,5BUO,5BUW,5BUX,2OCS,4KAF,2O9S,5LKA,3MNO,3P31,2UV2,5JLB 9322 57298693 48819 CHEMBL1644028 4529 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50919439 [O-][N+]([O-])=O InChI=1S/NO3/c2-1(3)4/q-1 NHNBFGGVMKEFGY-UHFFFAOYSA-N 26988 CHEMBL1644029::CHEMBL1644698::CHEMBL186200::NO3-::nitrate ion::nitrooxidane Carbonic anhydrase 4 Homo sapiens 58700000 ChEMBL 10.1016/j.bmc.2010.12.033 10.7270/Q2ST7QT4 21211980 Ekinci, D; Ceyhun, SB; Senturk, M; Erdem, D; Kufrevioglu, OI; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26988&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search NO3 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943 57298698 29785 CHEMBL1644698CHEMBL1644029 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50919440 [O-]N=O InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1 IOVCWXUNBOPUCH-UHFFFAOYSA-M 26989 CHEMBL93268::NO2-::nitrite::nitrite ion Carbonic anhydrase 4 Homo sapiens 30800000 ChEMBL 10.1016/j.bmc.2010.12.033 10.7270/Q2ST7QT4 21211980 Ekinci, D; Ceyhun, SB; Senturk, M; Erdem, D; Kufrevioglu, OI; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26989&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search NO2 1WA2,2XWZ,1J9T,2DWT,2DWS,2XX1,5VZO,5VZN,5VZQ,5VZP,5OG5,5D4I,5D4H,1FDI,5AKR,5NGX,3V2Z,3V2V,7ZCR,7ZCS,7ZCP,7ZCQ,7ZCN,7ZCO,3VKP,3TGC,1SJM,5HLX,3X1N,5F7A,3MM9,2FRF,2FRI,3BNH,6QQ2,3S7W,3RKH,3OO5,3OO4,1AS8,1AS6,4CSZ,5TR7,3D1I,6GT0,6GTL,6GTN,6GTI,6GTK,6FL2,3OUO,5OBO,5HWZ,3ONZ,4JRE,2XZI,2QMK,3VKR,3VKQ,7OU5,7OU7,7OU9,7OUY,5Z7E,5Z7F,5UT9,5UT7,3MLK,5UTA,5UTD,3GEO,5NC0,2E80,4N8T,6QWG,3OWM,4M4U,4L3Y,4L3X,4L3Z,4L38,8ING,3HEO,3HEP,6NU9,6TFD,3WKP,5OGG,5OGF,5OG3,5OG4,5OG6,5ZCY,6PDV,3OV9,3Q09,6GB8,6GBY,5OG2,5OFF,5OFG,5OFC,5OFH,5OF6,5OF7,5OF5,5OF8,4G1V,1NID,1NDS,2PPC,4I6Y,3VAU,3Q08,1J9R,1J9S,1J9Q,3LR7,3LR9,2YBI,2YBJ,2YBN,2BWD,2BWI,6ZAX,6ZAU,6ZAT,6GBB,2QV4,7WYJ,3MIB,3MIG,2O5S,2O5O,3MVF,3VM0,1L9O,1L9P,1L9Q,1L9R,1L9S,1L9T,3D7O,5I6P,5I6K,5I6L,5I6M,5I6N,2YBL,1KBV,6QPX,6QPT,2JIR,2JIQ,6CF0,6ZU6,6ZUB,6ZUA,6ZUD,5AG1,6QQ0 946 57298699 16301 CHEMBL93268 DB09112 C00088 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50919441 [N-]=[N+]=[N-] InChI=1S/N3/c1-3-2/q-1 IVRMZWNICZWHMI-UHFFFAOYSA-N 26985 2-triaza-1,2-diyne::CHEMBL79455::CHEMBL89295::N3(-1)::azide Carbonic anhydrase 4 Homo sapiens 65100000 ChEMBL 10.1016/j.bmc.2010.12.033 10.7270/Q2ST7QT4 21211980 Ekinci, D; Ceyhun, SB; Senturk, M; Erdem, D; Kufrevioglu, OI; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26985&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZI 1PPJ,1PP9,5NYW,4JKX,7WNL,7WNK,4QU0,4ESJ,3PHM,2VHB,4PJY,3MOO,1TH2,2BBR,1JKV,1UGB,1ZWN,3LJ9,3BGO,2B5Z,4QTY,1NXD,3N7U,4BFG,7QHM,3JTM,6QKN,2IUO,1MNG,1RSV,1RSR,1U06,1OCZ,2WWN,2EIE,2OZP,1S6A,1LKP,2WJP,4QUQ,4QUB,4QUG,4QUE,4QUJ,4QUH,4QUL,4QU9,7W6W,3SWJ,2RG9,3AH9,8GVM,2FHX,1KOP,1W6W,3PG8,3PG9,2VQ1,1T0R,5T30,4OQC,4EB2,6VOB,3DKE,3HWL,1PHM,3S7W,7THQ,7THN,4YTG,4YTB,1QWL,8BXX,3E7A,3E7B,3ABW,1ZYT,6BG0,6BG4,6BGQ,6BGR,6BGK,5O4Q,1ASQ,6T3O,4PR8,1EKJ,4RBM,3UCN,4POE,3MLL,2WQY,5L6X,5FQU,1IVJ,2BGA,2BG6,4NAJ,3L74,1VR8,4JYY,3QM9,2BL1,3P24,2A4T,6BFO,6BFL,6BFJ,6T9W,6T9X,4C5P,3VVK,3ZJO,3ZJS,2NAD,2CUU,3G3X,3G3W,3G3V,3QGU,3D2O,2BFK,2BFL,2BFZ,1RAY,2H88,4N7T,6R2U,3E15,6T81,2CK3,1CVA,1A4E,5OHH,2WSR,6UBE,5MBA,5Z85,5Z84,5Z86,2JLM,7ARZ,3LO1,3P9F,3P9O,1QWM,6BDV,1FS9,5A12,6D4B,6D4C,4JAC,5DN9,3CWB,4FSK,4XYB,2TSB,6M0A,2J8M,2J8R,3C61,5ZCO,5ZCP,5ZCQ,4PUV,4JQG,4NB7,1OS2,4WZV,3BAX,2Y68,1AZI,3HFU,6ALV,4Y8G,4Y8H,4Y84,2MHR,5IN2,1SZ6,3L75,3B4P,3RC3,5EDF,2FBW,1AVM,1AVN,6NKC,4OTX,3FUC,1YAZ,3BAW,1I3E,1OQ4,1NEG,7O8C,3GAS,5IBP,3DWQ,2D23,2IVB,2VUO,1UGF,4JIJ,5JDT,1ONK,3MIH,3MIC,3MIE,3MID,2JJ2,2JJ1,2O5M,1ISC,6VP2,3SID,3L2X,3ZWH,1SXZ,1OPM,2X5O,2GSD,5AG2,2E86,1BJE,1VNC,2VI7,7NOX,6TB6,3DHG,2JIZ,1ZLZ,2BCP,1S8N,5MUN,7RNZ,2ZO5,1SWM,2IVG,2A06 33558 57298695 30105 CHEMBL79455CHEMBL89295 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50919442 [Br-] InChI=1S/BrH/h1H/p-1 CPELXLSAUQHCOX-UHFFFAOYSA-M 26980 Br-::CHEMBL1644030::CHEMBL1644694::bromide::bromide ion Carbonic anhydrase 4 Homo sapiens 90000 ChEMBL 10.1016/j.bmc.2010.12.033 10.7270/Q2ST7QT4 21211980 Ekinci, D; Ceyhun, SB; Senturk, M; Erdem, D; Kufrevioglu, OI; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26980&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BR 1Y63,1XVC,1K6E,1K63,5Y24,2X42,2X40,2X41,1IHR,1XOK,2O29,7U5Q,1XMT,7WNL,7WNK,4B29,5VWW,3FFQ,2HC0,3I32,2V2Q,2V2V,5VZ4,4G6V,4KK6,6DRQ,2HTL,2HTK,4U9S,4U9Y,7PSF,4PM3,4BQO,1L0Z,3R1D,3R1E,1RER,5C0E,3DD7,2XMD,5C0T,5C0U,7QIK,2J3S,7M54,1QUI,1M3D,4YGJ,2HYP,4GP3,7TA2,4TM3,4TM1,4TM4,4DX8,4ICH,1OVL,3STV,6R62,5NGW,7L1E,2Q44,2IUO,2VR4,3ZOZ,8OKM,3GW6,6DDA,6DV1,7KK8,6VHX,6VHZ,6VHQ,6VHT,6VHU,6VHW,3MNG,5WC8,6FAQ,2FSX,7OP6,7OP7,1GED,1L1G,7Z57,5D5F,4DR9,6FN6,3FYS,4FBM,6EZ1,5AV2,6EZY,5AV4,1N8B,1VP6,3ZRG,8C7X,2B4G,3NEG,6LWY,6ZXX,7B9A,7KM7,7KM9,6G35,6HPD,6HPQ,6EQQ,6TQD,1IJV,4IO1,6I3A,3C9A,7ROO,2VQU,2VQT,7RDE,2XQ3,1EAO,5MNU,7QTX,3F2F,4TPY,4TPU,6CNU,5EXG,2VF3,3I18,6FZ6,3U6X,2WPF,4JRW,5JSP,5JSR,6H0A,7CUD,2J19,2J18,5H11,7DW5,1N9K,3Q4W,3LLP,7O21,7KK9,7T0H,7T0Y,1GQB,1GQP,5DSF,3SVD,3SVE,7QWI,6HSW,5M76,3V08,7L32,1IMX,3KLC,4R6C,6SMA,6GIV,4GAO,7RLM,1D2V,5HMJ,4WHI,2VPS,2VPM,5AV1,5GXY,5GXZ,1NUF,1NUD,2CIV,2CIZ,4LU4,6T36,6T38,2XPN,3MPR,6HTK,4F8L,4HC6,5S9S,7XBY,5U2P,1MHK,7P5T,2HLF,3DLU,4POD,4POC,4N6C,2WQ1,2WQ4,2XQG,3C51,4HH5,4HHQ,4HHO,3FPG,3FPF,3FPE,3FPJ,2EWF,4MY6,3LBO,2O2I,5G2A,1TO3,2XNT,5JTC,2QKI,7NBV,2AWD,2WDU,7O9R,5WV3,5MWK,3M3G,2HT4,2HT2,2HT3,2EZ0,7LGT,3LM7,7O5I,7O5T,7O5W,7O5V,7O5R,2ZC1,3BBZ,5LWQ,4JYE,4JYD,5LXR,5VEH,1F08,2QFE,4IFD,5NBX,5M65,8FC0,4QKO,3ONB,3ONC,6TS9,2BYD,6LZX,6LZY,6GJT,6RRV,2VOT,3F0O,3F0P,6GL4,6FY8,1Q3O,7KKR,6NLH,4H5B,2FPR,5L7F,1DOC,1DOE,2R4G,1RAZ,6M9G,5DZ6,7F9U,7F9V,8SA7,6S5H,7AS0,7O45,6BPA,4JXI,5FEA,1SR4,4R86,6R2N,3V6Q,5GXF,3O7O,6Y3A,5C5V,2X3H,5FHR,2J6L,6GKI,5SMJ,5FKR,367D,2FE8,4N8O,1D07,2HEK,4LS4,4LSI,4LSH,4LSE,4LSF,5SWA,3HNO,3A3K,6XQP,5EFH,1ROC,6SUT,7QJL,3TU8,3TUU,3LD5,6BZQ,6BZT,4CO6,5IL0,2FKK,3S8Y,2XHY,3DY9,3DYE,6GVA,5AMT,4ABL,8CIR,3Q17,1P2X,1YIY,1YIZ,1LZ9,1D7W,7QFK,4GIO,1PWX,6HTM,5S9W,5S9V,5S9U,5S9T,5S9Z,5S9Y,5S9X,7CXD,2DGL,7STU,3LZ3,6NX2,5LXY,6JU1,2VMF,6TF2,6TFE,6TFF,1WY0,4PWC,3F6O,4UJA,5U79,5U7C,5U7B,5U7A,2H34,5FKT,4KVH,4XY8,6PKY,2HI8,3R47,5OGX,6V9D,4HMK,7OW7,4MTM,3LEP,6PDK,7ECD,5I5P,6H42,6H45,1OSY,4ACK,2OJT,3LPH,2NTI,4M5X,6ARZ,3GGQ,6GBG,5SV6,3A0B,7M3R,1AZF,6QN3,7ZD4,7VTI,2YKF,7OLO,4C8U,5SCO,2FCV,4MO1,1KJL,1W99,7YUG,3MD9,4AZI,2VL4,7PD1,4LQK,2V6Q,8FHJ,4OWH,4OWB,5C9E,1EG6,3F75,7VGT,7VGU,7Q14,7OM3,8B3W,7SWS,4BWO,7Z00,5IUX,3UPT,6RO3,6MEI,4QH1,6P1M,6BXR,4K4R,1IZ8,6IYX,5FKS,6HM7,3G4Z,1JHD,6OMI,4Q7O,3LQL,3LQG,4P98,4P9P,4P9O,5OPP,4Q1U,1CIJ,8ADQ,4YD4,7KKB,7KKA,1FJ2,3EKI,5EUS,5AWX,2P3H,5FKQ,4ERR,4ER6,5CYQ,6FT9,7QQ7,7BEN,2G2P,7OCN,3X41,3X42,1MGY,1XEQ,7PEP,7REF,6W0S,7NUP,8ARC,7OLQ,7OLT,7OLK,7OLL,7OLM,4H3S,5LFT,6ZWI,6ZWE,4NKU,4NKT,4Y9F,4Y9C,4NSG,6RNU,4M5W,4KCO,4KCM,2CIX,2CIY,6YOD,6YOE,6YOB,6YOC,5YER,6Z6R,6Z6D,4R34,6Z8G,2RC3,2RC7,7O8Z,7O8Y,7O87,7FIB,3QBK,4Q2A,1F5M,3K9U,1HD2,3EJZ,3EJY,3O31,3USH,4B0O,3SSK,5MJ6,3WCR,5T7A,5GU5,5SAS,5SA3,5SA2,5SA1,5SA0,2VJX,5N7L,3CXM,3F59,5U82,5U83,5FQE,4DEY,6KTZ,4OXS,5IWO,5IWN,6ZVO,4PA3,5MPW,3BIY,1L9M,4QRY,3D7R,6K5I,6K5F,6K5D,6K5A,7A0H,3SRE,3SRG,2WBK,2WB9,6XKE,6S29,4B4P,1N0R,6AQK,6JL0,6KW0,4IL9,5SK7,5N2A,6QML,4W6T,6TII,6AD7,6AD8,6ADB,6ADA,3GUD,4P4G,5D5C,7QW3,4PA4,5ZQU,6D0G,8BAO,7PGO,3I4U,6TB7,6F01,4BRP,7KQ9,5GY1,5GY0,6XTD,3FLH,8CX9,4YEM,4Z0T,6KU2,8D87,4PA9,7TMD,3G99,5DAV,2WHR,2WH6,2VO5,6XAW,5M92,4C46,4KAH,5N6X,4XJF,4XJG,5Y9S,6YMN,4FBS,6K6J,4GOY,4GOV,5AHZ,3IVN,3M4H,6QGL,1N11,4GP0 259 57298690 64428 CHEMBL11685CHEMBL1644030CHEMBL1644694 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50919443 [Cl-] InChI=1S/ClH/h1H/p-1 VEXZGXHMUGYJMC-UHFFFAOYSA-M 26979 CHEMBL69710::Cl-::POTASSIUM CHLORIDE::SODIUM CHLORIDE::chloride::chloride ion Carbonic anhydrase 4 Homo sapiens 90000 ChEMBL 10.1016/j.bmc.2010.12.033 10.7270/Q2ST7QT4 21211980 Ekinci, D; Ceyhun, SB; Senturk, M; Erdem, D; Kufrevioglu, OI; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26979&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CL 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312 57298689 64428 CHEMBL19429CHEMBL69710 2339 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50919444 [O-]S([O-])(=O)=O InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 QAOWNCQODCNURD-UHFFFAOYSA-L 26992 CHEMBL183495::SO4(2-)::SODIUM SULFATE::sulfate::sulfate ion Carbonic anhydrase 4 Homo sapiens 9000000 ChEMBL 10.1016/j.bmc.2010.12.033 10.7270/Q2ST7QT4 21211980 Ekinci, D; Ceyhun, SB; Senturk, M; Erdem, D; Kufrevioglu, OI; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26992&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SO4 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1117 57298702 29922 CHEMBL183495 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50919445 [F-] InChI=1S/FH/h1H/p-1 KRHYYFGTRYWZRS-UHFFFAOYSA-M 26978 BDBM50098540::CHEMBL1528::CHEMBL1644027::F-::fluoride::fluoride ion Carbonic anhydrase 4 Homo sapiens 70000 ChEMBL 10.1016/j.bmc.2010.12.033 10.7270/Q2ST7QT4 21211980 Ekinci, D; Ceyhun, SB; Senturk, M; Erdem, D; Kufrevioglu, OI; Supuran, CT Ondokuz Mayis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26978&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search F 6WO7,5EVC,6WOA,3MBA,6WO8,2WVG,4KKL,4KK8,7TN4,2XMC,2Q9P,6QDY,6YTT,3VRS,4F60,7KK8,6JIM,1E6A,1LH5,6RI8,6RI6,6RI4,6RIL,6RIK,6RII,1BS3,7T0Y,5NAI,6EVH,5A43,6VCM,6VCL,6LL8,6B2B,6B2A,6B2D,6B24,6BQO,5VEJ,2QFP,5KBN,2LH5,5KOM,3HQ2,6WOB,7TJ1,7F9V,2WSL,2AUU,2AU6,2AU9,6A24,4X30,4ENC,4ENB,4ENA,5K91,1T5G,6BX4,6BX5,6VCK,2AKZ,5NKQ,7KKB,7KKA,3PPM,5XB2,3SSV,4CEX,1NEL,2UVN,2HAW,5XD5,4JB4,4X00,6HOO,2DQZ,4Q3K,6D0J,6D0K,6D0N,7SP3,4KJQ,6WOI,4EN5,4GOA,2Z5Z 28179 57298688 64428 CHEMBL1644027CHEMBL1528CHEMBL1362 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906141 O=c1ccc2ccc(OCc3ccccc3)cc2o1 InChI=1S/C16H12O3/c17-16-9-7-13-6-8-14(10-15(13)19-16)18-11-12-4-2-1-3-5-12/h1-10H,11H2 QDLFCBKKECTJSK-UHFFFAOYSA-N 50378564 CHEMBL145781 Carbonic anhydrase 4 Homo sapiens 5800 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378564&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 910172 160857647 CHEMBL145781 ZINC00493069 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906142 CCCCOc1ccc2ccc(=O)oc2c1 InChI=1S/C13H14O3/c1-2-3-8-15-11-6-4-10-5-7-13(14)16-12(10)9-11/h4-7,9H,2-3,8H2,1H3 BDOGTORASJEUBW-UHFFFAOYSA-N 50303502 7-butoxy-2H-chromen-2-one::CHEMBL571514 Carbonic anhydrase 4 Homo sapiens 61200 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303502&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156219 104157863 CHEMBL571514 ZINC02950199 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906143 CCCOc1ccc2ccc(=O)oc2c1 InChI=1S/C12H12O3/c1-2-7-14-10-5-3-9-4-6-12(13)15-11(9)8-10/h3-6,8H,2,7H2,1H3 FCCCOTWGEKNZMI-UHFFFAOYSA-N 50303501 7-propoxy-2H-chromen-2-one::CHEMBL568516 Carbonic anhydrase 4 Homo sapiens >500000 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303501&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1631814 104157862 CHEMBL568516 ZINC01893420 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906144 CCOc1ccc2ccc(=O)oc2c1 InChI=1S/C11H10O3/c1-2-13-9-5-3-8-4-6-11(12)14-10(8)7-9/h3-7H,2H2,1H3 LIFAQMGORKPVDH-UHFFFAOYSA-N 50303500 7-ethoxy-2H-1-benzopyran-2-one::7-ethoxycoumarin::CHEMBL191528::Ethylumbelliferone Carbonic anhydrase 4 Homo sapiens 35700 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303500&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 35703 104157861 28184 CHEMBL191528 C11052 ZINC00057719 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906145 COc1ccc2ccc(=O)oc2c1 InChI=1S/C10H8O3/c1-12-8-4-2-7-3-5-10(11)13-9(7)6-8/h2-6H,1H3 LIIALPBMIOVAHH-UHFFFAOYSA-N 50303499 7-(methyloxy)-2H-chromen-2-one::7-Methoxycoumarin::7-methoxy-2H-1-benzopyran-2-one::Ayapanin::CHEMBL49732::Herniarin::Herniarine::Methylumbelliferone Carbonic anhydrase 4 Homo sapiens 8300 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303499&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EBF 6JF0 10748 104157860 5679 CHEMBL49732 C09268 ZINC00391177 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906146 O=c1ccc2ccccc2o1 InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 12342 2H-chromen-2-one::CHEMBL6466::Coumarin Carbonic anhydrase 4 Homo sapiens 6800 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12342&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search COU 2PMJ,2H90,3L5M,3L68,3L66,3CRB,1Z10,4UTI,4UTL,2PWB 323 172097204 28794 CHEMBL6466 DB04665 C05851 ZINC00074709 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906147 COc1cc2oc(=O)ccc2cc1[C@@H](O)CC(C)C InChI=1S/C15H18O4/c1-9(2)6-12(16)11-7-10-4-5-15(17)19-13(10)8-14(11)18-3/h4-5,7-9,12,16H,6H2,1-3H3/t12-/m0/s1 ZRXJDVGAMZQYJX-LBPRGKRZSA-N 50300203 (S)-6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one::6-(1S-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one::CHEMBL572366 Carbonic anhydrase 4 Homo sapiens >500000 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300203&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 45484187 104154564 CHEMBL572366 ZINC32236516 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50908561 Oc1ccccc1O InChI=1S/C6H6O2/c7-5-3-1-2-4-6(5)8/h1-4,7-8H YCIMNLLNPGFGHC-UHFFFAOYSA-N 26188 α-CA inhibitor, 12::1,2-Dihydroxybenzene, XI::1,2-dihydroxybenzene::CHEMBL280998::benzene-1,2-diol::phenol derivative, 2 Carbonic anhydrase 4 Homo sapiens 10900 ChEMBL 10.1016/j.bmc.2010.01.076 10.7270/Q2GQ6ZP1 20185318 Innocenti, A; Beyza Ozturk Sarikaya, S; Gulcin, I; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26188&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CAQ 2BUY,2BUQ,4QON,3HHY,2PUM,4ZXT,5KBI,3O4M,6S2H,1DLT,5SWG,7WKM,7WKL,1XEP,3FW4,4K7I,7KK0,7WJR,3T67,7WMB,1KND,7BP1,5VXT,3MI5,5G4H,4OOW 289 56464625 18135 CHEMBL280998 DB02232 C00090 ZINC13512214 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50908573 Oc1ccccc1 InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H ISWSIDIOOBJBQZ-UHFFFAOYSA-N 26187 α-CA inhibitor, 11::CHEMBL14060::US9688816, 2::phenol Carbonic anhydrase 4 Homo sapiens 9500 ChEMBL 10.1016/j.bmc.2010.01.076 10.7270/Q2GQ6ZP1 20185318 Innocenti, A; Beyza Ozturk Sarikaya, S; Gulcin, I; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26187&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IPH 2PZV,3NX8,1XDA,4OLA,1MPJ,1PN0,5HPU,7AT0,1XW7,3AIY,3NC0,5USS,1JHY,1JHX,1WAV,2OMB,2OMN,3ROV,1FOH,5KI6,4W5Q,4W5R,4W5T,4W5N,1Q4V,4W5O,5URU,5JS1,5JS2,3ZS2,1XU5,6IY8,1AIY,5UU4,5UU3,6MFN,6MFR,1LI2,3Q3O,7JP3,3V1G,3V19,3JSD,5AIY,6Q7S,4A71,5FRW,2OLD,3ZQR,6TYH,3KQ6,3P2X,4JMW,5KBE,2WS6,2WS7,2J9N,1ZNJ,6MDZ,5ILG,1V03,7WDG,7WDH,1RWE,3KMH,4Z4F,4Z4G,4Z4D,4Z4E,4Z4C,4Z4H,4Z4I,1QIY,5BQQ,4F3T,1ZEG,6CK2,5W3R,4AIY,7VQF,1FJW,3GKY,4P65,5NQ8,1W8P,3U3E,5EMS,4AJZ,5T7B,3F39,4H07,4I7L,1AI0,1AI7,4AKJ,2AIY,2VE7,5HRQ,3GUO,5UDP,5WEA,4HDS,5UQA,2AS3,3P33,1LPH,6Z44 996 56464624 15882 CHEMBL14060 DB03255 C00146 ZINC05133329 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50908588 Oc1cc2c3c(oc(=O)c4cc(O)c(O)c(oc2=O)c34)c1O InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H AFSDNFLWKVMVRB-UHFFFAOYSA-N 4078 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(14),4(16),5,7,11(15),12-hexaene-3,10-dione::CHEMBL6246::ELLAGIC ACID::Elagic Acid::Ellagic acid (18)::Ellagic acid dihydrate::MLS000069632::SMR000058244::cid_5281855 Carbonic anhydrase 4 Homo sapiens 9080 ChEMBL 10.1016/j.bmc.2010.01.076 10.7270/Q2GQ6ZP1 20185318 Innocenti, A; Beyza Ozturk Sarikaya, S; Gulcin, I; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4078&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search REF 4YUA,2ZJW,6RWD 5281855 8033769 4775 CHEMBL6246 DB08468 C10788 ZINC03872446 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50908597 Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H REFJWTPEDVJJIY-UHFFFAOYSA-N 7460 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate::CHEMBL50::Quercetin::Quercetin (10)::Quercetin (21)::Quercetin (Qur)::US11021454, Compound Quercetin::US9180183, Quercetin::med.21724, Compound 4 Carbonic anhydrase 4 Homo sapiens 7890 ChEMBL 10.1016/j.bmc.2010.01.076 10.7270/Q2GQ6ZP1 20185318 Innocenti, A; Beyza Ozturk Sarikaya, S; Gulcin, I; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7460&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search QUE 3BPT,2HCK,3LJ0,4LMU,5FLI,5FLJ,3CF8,4DFU,4MRA,4WNJ,2O3P,2MS6,5AUW,3BXX,6M89,3LM5,1GP6,6AWS,6QCN,6QCD,7VUM,6B1D,2N6C,1E8W,2C9Z,5XG4,5A4V,2UXH,1H1I,2JJ2,6TTA,6IJD,3NVY 5280343 11108251 16243 CHEMBL50 DB04216 5346 C00389 ZINC03869685 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50908609 COc1cc(cc(OC)c1O)C(O)=O InChI=1S/C9H10O5/c1-13-6-3-5(9(11)12)4-7(14-2)8(6)10/h3-4,10H,1-2H3,(H,11,12) JMSVCTWVEWCHDZ-UHFFFAOYSA-N 50187132 3,5-Dimethoxy-4-hydroxybenzoic acid::4-hydroxy-3,5-dimethoxybenzoic acid::CHEMBL1414::Syringic acid Carbonic anhydrase 4 Homo sapiens 10600 ChEMBL 10.1016/j.bmc.2010.01.076 10.7270/Q2GQ6ZP1 20185318 Innocenti, A; Beyza Ozturk Sarikaya, S; Gulcin, I; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50187132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50187132&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IJP 10742 104071149 68329 CHEMBL1414 C10833 ZINC00156386 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50908621 OC(=O)c1cc(O)c(O)c(O)c1 InChI=1S/C7H6O5/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,8-10H,(H,11,12) LNTHITQWFMADLM-UHFFFAOYSA-N 50085536 3,4,5-Trihydroxybenzoate, X::3,4,5-trihydroxybenzoic acid::CHEMBL288114::Gallic Acid, F::gallic acid Carbonic anhydrase 4 Homo sapiens 9800 ChEMBL 10.1016/j.bmc.2010.01.076 10.7270/Q2GQ6ZP1 20185318 Innocenti, A; Beyza Ozturk Sarikaya, S; Gulcin, I; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085536&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search GDE 4IC0,4J0H,3WRB,4Z5X,3WKU,3WPM,3WR9,3WR4,3WR3,7K4O 370 103984979 30778 CHEMBL288114 C01424 ZINC00001504 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50908633 COc1cc(\C=C\C(O)=O)ccc1O InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+ KSEBMYQBYZTDHS-HWKANZROSA-N 50214744 (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid::(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid (10)::CHEMBL32749::Ferulic acid (M5)::ferulic acid Carbonic anhydrase 4 Homo sapiens 10800 ChEMBL 10.1016/j.bmc.2010.01.076 10.7270/Q2GQ6ZP1 20185318 Innocenti, A; Beyza Ozturk Sarikaya, S; Gulcin, I; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214744&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search FER 3NX2,1GKL,4PME,6G21,7ATJ,3PFC,2BNJ,1JT2,6YUX,1GW2,1GWT,6ATJ,7Z2U,1KYZ,7NTD,1UWC,3CBG,2BJH,5CXX,4RGU,4JB0,2WTN,6HOV,6HOQ,6HOP,6MBY,5X14 445858 104089679 17620 CHEMBL32749 DB07767 C01494 ZINC00058258 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50908645 OC(=O)\C=C\c1ccc(O)c(O)c1 InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+ QAIPRVGONGVQAS-DUXPYHPUSA-N 4375 (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid::(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid (9)::3,4-Dihydroxycinnamate, XVII::CHEMBL145::Caffeic acid::Caffeic acid, 1::cid_689043 Carbonic anhydrase 4 Homo sapiens 10100 ChEMBL 10.1016/j.bmc.2010.01.076 10.7270/Q2GQ6ZP1 20185318 Innocenti, A; Beyza Ozturk Sarikaya, S; Gulcin, I; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4375&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search DHC 3HOF,2O7D,4FB4,1KOU,6YRI,4YU7,6AWU,4EYQ,5VFJ,6I72,7NRR,3S2Z,4N0S 689043 8034051 16433 CHEMBL145 DB01880 5155 C01197 ZINC00058172 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50908657 OC(=O)\C=C\c1ccc(O)cc1 InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+ NGSWKAQJJWESNS-ZZXKWVIFSA-N 4374 (2E)-3-(4-hydroxyphenyl)prop-2-enoic acid::(2E)-3-(4-hydroxyphenyl)prop-2-enoic acid (8)::CHEMBL66879::p-Coumaric Acid::p-Hydroxycinnamic acid (p-HCA)::p-hydroxycinnamic acid::p-hydroxycinnamic acid (M4) Carbonic anhydrase 4 Homo sapiens 9600 ChEMBL 10.1016/j.bmc.2010.01.076 10.7270/Q2GQ6ZP1 20185318 Innocenti, A; Beyza Ozturk Sarikaya, S; Gulcin, I; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4374&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search HC4 3PHY,5J0A,2O7B,2O7F,2J3J,1GSX,1GSW,1GSV,4I3J,5MOV,3UME,3UMD,6UN2,3VE4,3VE3,1TS6,1TS7,1TS0,1TS8,1F98,1F9I,2QJ5,2QJ7,1OTD,1OTE,1OTB,8DZX,8DZY,8DZU,5GX9,1T18,1T19,1T1A,1T1B,1T1C,4F8J,1S4R,1S4S,2PYP,6MMD,4EYO,2I9V,3UBA,6UMY,6VZK,5VFM,5Y8T,1XFQ,1XFN,1NWZ,4I3A,2PHY,2KX6,8E1L,4WL9,1OTI,3A5R,3PYP,1S1Z,1S1Y,1OTA,1OT6,1OT9,2D01,4QEM,4HY8,1UWN,1D7E,8E03,8E02,8E09,1ODV,1UWP,6MKT,4BBT,4BBU,4BBV,1UGU,4RGR,6TC2,7NR2,8E1K,2D02,7SJJ,2PYR,4WLA,4B9O,2QWS,7NSW,7SPV,7SPW,7SPX,4I38,4I39,4I3I,1MZU,4ALB,2ZOI,2ZOH,5X13 637542 8034050 36090 CHEMBL66879 DB04066 5787 C00811 ZINC00039811 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50908669 OC(=O)c1ccc(O)cc1 InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10) FJKROLUGYXJWQN-UHFFFAOYSA-N 26194 4-Hydroxybenzoate, III::4-hydroxybenzoic acid::CHEMBL441343::p-Hydroxybenzoic acid::phenol derivative, 8 Carbonic anhydrase 4 Homo sapiens 7780 ChEMBL 10.1016/j.bmc.2010.01.076 10.7270/Q2GQ6ZP1 20185318 Innocenti, A; Beyza Ozturk Sarikaya, S; Gulcin, I; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26194&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PHB 2BUW,2BUR,1G81,1BKW,6KCL,6KCM,6KCK,1IUW,1IUV,1IUX,1PXB,1PDH,3ZYB,1G1B,1CJ2,1Q4S,5D2A,4LKE,4LKD,4LKF,4OD5,1CC4,1PBE,1BF3,4EVS,4EVQ,4EY3,3TYB,1BGJ,1BGN,1DOB,1DOC,5IGA,2PHH,1PXA,7CUO,1K0I,4F06,3PCC,5I5P,1CJ3,7DQB,1TT8,6AL9,1JD3,1PXC,1CC6,1YKJ,3HGR,3HGS,1D7L,5RTJ,4E3G,1CJ4,3R3A,3R36,1FW9,7ON9,5W1E,5M21 135 56464631 30763 CHEMBL441343 DB04242 C00156 ZINC00332752 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50908681 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2010.01.076 10.7270/Q2GQ6ZP1 20185318 Innocenti, A; Beyza Ozturk Sarikaya, S; Gulcin, I; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50913629 NS(N)(=O)=O InChI=1S/H4N2O2S/c1-5(2,3)4/h(H4,1,2,3,4) NVBFHJWHLNUMCV-UHFFFAOYSA-N 26995 CHEMBL355001::H2NSO2NH2::sulfamamide::sulfamide::sulfamoylamine Carbonic anhydrase 4 Homo sapiens 880 ChEMBL 10.1016/j.bmcl.2010.04.114 10.7270/Q2NV9K7Q 20472429 Di Fiore, A; Monti, SM; Innocenti, A; Winum, JY; De Simone, G; Supuran, CT Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26995&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search FUS 6D2N 82267 57298705 48266 CHEMBL355001 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50913646 CC1(C)O[C@@H]2CO[C@@]3(CNS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H22N2O7S/c1-10(2)18-7-5-17-12(6-14-22(13,15)16)9(8(7)19-10)20-11(3,4)21-12/h7-9,14H,5-6H2,1-4H3,(H2,13,15,16)/t7-,8-,9+,12+/m1/s1 NQRKKQKMTGLNOZ-XBWDGYHZSA-N 13055 CHEMBL283695::Compound 8::Topiramate Sulfamide Analogue 8::amino-N-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}sulfonamide Carbonic anhydrase 4 Homo sapiens 941 ChEMBL 10.1016/j.bmcl.2010.04.114 10.7270/Q2NV9K7Q 20472429 Di Fiore, A; Monti, SM; Innocenti, A; Winum, JY; De Simone, G; Supuran, CT Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13055&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search B19 2H15 10712038 46513475 CHEMBL283695 ZINC13612331 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50913657 CC1(C)OB(OC1(C)C)c1ccc(NS(N)(=O)=O)cc1 InChI=1S/C12H19BN2O4S/c1-11(2)12(3,4)19-13(18-11)9-5-7-10(8-6-9)15-20(14,16)17/h5-8,15H,1-4H3,(H2,14,16,17) YQWUJQMJCQBCRA-UHFFFAOYSA-N 50167367 (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylsulfamide::CHEMBL190447::N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]aminosulfonamide::N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfamide Carbonic anhydrase 4 Homo sapiens 8620 ChEMBL 10.1016/j.bmcl.2010.04.114 10.7270/Q2NV9K7Q 20472429 Di Fiore, A; Monti, SM; Innocenti, A; Winum, JY; De Simone, G; Supuran, CT Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167367&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BON 3MNU 44399654 104052634 CHEMBL190447 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50913670 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2010.04.114 10.7270/Q2NV9K7Q 20472429 Di Fiore, A; Monti, SM; Innocenti, A; Winum, JY; De Simone, G; Supuran, CT Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50913683 CCOc1ccc2nc(sc2c1)S(N)(=O)=O InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) OUZWUKMCLIBBOG-UHFFFAOYSA-N 10882 6-ethoxy-1,3-benzothiazole-2-sulfonamide::CHEMBL18::Ethamide::Ethoxazolamide::Ethoxzolamide::Ethoxzolamide (EZA)::Ethoxzolamide, EZM::Sulfonamide, 3::US10172837, Ethoxyzolamide::sulfonamide 3 Carbonic anhydrase 4 Homo sapiens 93 ChEMBL 10.1016/j.bmcl.2010.04.114 10.7270/Q2NV9K7Q 20472429 Di Fiore, A; Monti, SM; Innocenti, A; Winum, JY; De Simone, G; Supuran, CT Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10882&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EZL 3DD0,5JN9,3CAJ,3MDZ,6BCC,3DCW,6QL2,5TT3,6MWI 3295 46511452 101096 CHEMBL18 DB00311 6814 ZINC00056721 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50913696 CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 KJADKKWYZYXHBB-XBWDGYHZSA-N 10887 Sulfamate 7::Topiramate (TPM)::US11535599, Example topiramate::[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate Carbonic anhydrase 4 Homo sapiens 4900 ChEMBL 10.1016/j.bmcl.2010.04.114 10.7270/Q2NV9K7Q 20472429 Di Fiore, A; Monti, SM; Innocenti, A; Winum, JY; De Simone, G; Supuran, CT Istituto di Biostrutture e Bioimmagini-CNR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10887&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TOR 3LXE,3HKU,5JNA 5284627 46511457 63631 DB00273 6849 C07502 ZINC01530804 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50917240 Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1 InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+ LUKBXSAWLPMMSZ-OWOJBTEDSA-N 23926 (E)-resveratrol::5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol::CHEMBL165::Resveratol::Stilbene, 2f::cid_445154::resveratrol::trans-resveratrol Carbonic anhydrase 4 Homo sapiens 4470 ChEMBL 10.1016/j.bmcl.2010.07.038 10.7270/Q2HM59FX 20674354 Innocenti, A; Gulcin, I; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23926&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search STL 6JEM,7WAQ,4QOH,4QOJ,5NZL,1U0W,3MNQ,7K1C,2L98,8ABT,4DPN,2YDX,5CR1,7Q9O,3CKL,1Z1F,1SG0,4PP6,1CGZ,5J54,7CCU,7KD8,4JAZ,1DVS,7CCW,3FTS,5U90,5BTR,4QER,2JIZ,7VB8,4HDA,4Q93 445154 53785926 27881 CHEMBL165 DB02709 C03582 ZINC00006787 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50917241 CC(CCc1ccc(O)cc1)NCCc1ccc(O)c(O)c1 InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3 JRWZLRBJNMZMFE-UHFFFAOYSA-N 50325274 4-{2-[3-(4-Hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol::4-{2-[3-(4-Hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol(Dobutamine)::CHEMBL926::DOBUTAMINE::Dobutrex::cid_36811 Carbonic anhydrase 4 Homo sapiens 8980 ChEMBL 10.1016/j.bmcl.2010.07.038 10.7270/Q2HM59FX 20674354 Innocenti, A; Gulcin, I; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50325274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50325274&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search Y00 2Y01,2Y00,6H7L,8DCR 36811 117646595 4670 CHEMBL926 DB00841 535 C06967 ZINC00057278 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50917242 COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3 VFLDPWHFBUODDF-UHFFFAOYSA-N 50067040 ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione)::(1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one::(1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one::(1E,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione::(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione::(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione::(1Z,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione::(E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione::1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione::1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione::1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione::1,7-bis(4-hydroxy-3-methoxyphenyl)1,6-heptadiene-3,5-dione::1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione::1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione::5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one::5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one::CHEMBL116438::cid_5281767::curcumin I::curcumine::curcurmin::diferuloylmethane Carbonic anhydrase 4 Homo sapiens 4970 ChEMBL 10.1016/j.bmcl.2010.07.038 10.7270/Q2HM59FX 20674354 Innocenti, A; Gulcin, I; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067040&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CC9 6HDR 969516 103961572 CHEMBL116438 ZINC00899824 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50917243 O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1 InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15+/m0/s1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 23416 α-CA inhibitor, 3::(+)-Catechin::(2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol::CHEMBL311498::Catechin::D-Catechin Carbonic anhydrase 4 Homo sapiens 4900 ChEMBL 10.1016/j.bmcl.2010.07.038 10.7270/Q2HM59FX 20674354 Innocenti, A; Gulcin, I; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23416&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search KXN 3I52,4C94,4C9I 9064 50091680 15600 CHEMBL311498 C06562 ZINC00119983 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50917245 Oc1ccccc1 InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H ISWSIDIOOBJBQZ-UHFFFAOYSA-N 26187 α-CA inhibitor, 11::CHEMBL14060::US9688816, 2::phenol Carbonic anhydrase 4 Homo sapiens 9500 ChEMBL 10.1016/j.bmcl.2010.07.038 10.7270/Q2HM59FX 20674354 Innocenti, A; Gulcin, I; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26187&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IPH 2PZV,3NX8,1XDA,4OLA,1MPJ,1PN0,5HPU,7AT0,1XW7,3AIY,3NC0,5USS,1JHY,1JHX,1WAV,2OMB,2OMN,3ROV,1FOH,5KI6,4W5Q,4W5R,4W5T,4W5N,1Q4V,4W5O,5URU,5JS1,5JS2,3ZS2,1XU5,6IY8,1AIY,5UU4,5UU3,6MFN,6MFR,1LI2,3Q3O,7JP3,3V1G,3V19,3JSD,5AIY,6Q7S,4A71,5FRW,2OLD,3ZQR,6TYH,3KQ6,3P2X,4JMW,5KBE,2WS6,2WS7,2J9N,1ZNJ,6MDZ,5ILG,1V03,7WDG,7WDH,1RWE,3KMH,4Z4F,4Z4G,4Z4D,4Z4E,4Z4C,4Z4H,4Z4I,1QIY,5BQQ,4F3T,1ZEG,6CK2,5W3R,4AIY,7VQF,1FJW,3GKY,4P65,5NQ8,1W8P,3U3E,5EMS,4AJZ,5T7B,3F39,4H07,4I7L,1AI0,1AI7,4AKJ,2AIY,2VE7,5HRQ,3GUO,5UDP,5WEA,4HDS,5UQA,2AS3,3P33,1LPH,6Z44 996 56464624 15882 CHEMBL14060 DB03255 C00146 ZINC05133329 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50917246 OC(=O)\C=C\c1ccccc1O InChI=1S/C9H8O3/c10-8-4-2-1-3-7(8)5-6-9(11)12/h1-6,10H,(H,11,12)/b6-5+ PMOWTIHVNWZYFI-AATRIKPKSA-N 50146462 (2E)-3-(2-hydroxyphenyl)-2-propenoic acid::(2E)-3-(2-hydroxyphenyl)prop-2-enoic acid::(2E)-3-(2-hydroxyphenyl)prop-2-enoic acid (7)::(E)-2-hydroxycinnamic acid::(E)-3-(2-hydroxyphenyl)-2-propenoic acid::(E)-o-hydroxycinnamic acid::CHEMBL52564::o-Hydroxycinnamic acid (o-HCA)::o-hydroxy-trans-cinnamic acid::trans-2-coumaric acid::trans-o-hydroxycinnamic acid Carbonic anhydrase 4 Homo sapiens 62300 ChEMBL 10.1016/j.bmcl.2010.07.038 10.7270/Q2HM59FX 20674354 Innocenti, A; Gulcin, I; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50146462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50146462&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2HC 1V5Z,5BNL 637540 104035051 18176 CHEMBL52564 DB01650 C01772 ZINC00895911 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906311 O=c1ccc2cc(C[N+]34CN5CN(CN(C5)C3)C4)ccc2o1 InChI=1S/C16H19N4O2/c21-16-4-2-14-5-13(1-3-15(14)22-16)6-20-10-17-7-18(11-20)9-19(8-17)12-20/h1-5H,6-12H2/q+1 QWVAIAADSFBBHY-UHFFFAOYSA-N 50303498 1-(2-Oxo-2H-chromen-6-ylmethyl)-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1*3,7*]decane::CHEMBL578167 Carbonic anhydrase 4 Homo sapiens 11800 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303498&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 45485272 104157859 CHEMBL578167 ZINC45300690 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906312 NCc1ccc2oc(=O)ccc2c1 InChI=1S/C10H9NO2/c11-6-7-1-3-9-8(5-7)2-4-10(12)13-9/h1-5H,6,11H2 MXXNUQUOHJMQEU-UHFFFAOYSA-N 50303497 6-(aminomethyl)-2H-chromen-2-one::CHEMBL567139 Carbonic anhydrase 4 Homo sapiens 15000 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303497&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 45485270 104157858 CHEMBL567139 ZINC45245505 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906313 OCc1ccc2oc(=O)ccc2c1 InChI=1S/C10H8O3/c11-6-7-1-3-9-8(5-7)2-4-10(12)13-9/h1-5,11H,6H2 BPTGMUVORRVIEP-UHFFFAOYSA-N 50303496 6-(hydroxymethyl)-2H-chromen-2-one::CHEMBL571738 Carbonic anhydrase 4 Homo sapiens 7700 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303496&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 20195365 104157857 CHEMBL571738 ZINC44198895 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906314 CCOC(=O)c1cc2ccc(OC)cc2oc1=O InChI=1S/C13H12O5/c1-3-17-12(14)10-6-8-4-5-9(16-2)7-11(8)18-13(10)15/h4-7H,3H2,1-2H3 FWFVXBZXJKTVGL-UHFFFAOYSA-N 50303495 CHEMBL568385::ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate Carbonic anhydrase 4 Homo sapiens 7200 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303495&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 914298 104157856 CHEMBL568385 ZINC00499358 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906315 CCOC(=O)c1cc2cc(CO)ccc2oc1=O InChI=1S/C13H12O5/c1-2-17-12(15)10-6-9-5-8(7-14)3-4-11(9)18-13(10)16/h3-6,14H,2,7H2,1H3 LJKJRALGZCZICN-UHFFFAOYSA-N 50303494 CHEMBL568173::ethyl 6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylate Carbonic anhydrase 4 Homo sapiens 9100 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303494&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10586607 104157855 CHEMBL568173 ZINC39042869 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906316 COC(=O)c1cc2cc(CO)ccc2oc1=O InChI=1S/C12H10O5/c1-16-11(14)9-5-8-4-7(6-13)2-3-10(8)17-12(9)15/h2-5,13H,6H2,1H3 BVABSSGMJLREHA-UHFFFAOYSA-N 50303493 CHEMBL567896::methyl 6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylate Carbonic anhydrase 4 Homo sapiens >500000 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303493&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 45485283 104157854 CHEMBL567896 ZINC45254920 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906317 OC(=O)c1cc2ccccc2sc1=O InChI=1S/C10H6O3S/c11-9(12)7-5-6-3-1-2-4-8(6)14-10(7)13/h1-5H,(H,11,12) CIMFYGICTNZOPT-UHFFFAOYSA-N 50303492 2-oxo-2H-thiochromene-3-carboxylic acid::CHEMBL571519 Carbonic anhydrase 4 Homo sapiens 27900 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303492&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12394434 104157853 CHEMBL571519 ZINC39220095 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906318 COc1cccc2cc(C(O)=O)c(=O)oc12 InChI=1S/C11H8O5/c1-15-8-4-2-3-6-5-7(10(12)13)11(14)16-9(6)8/h2-5H,1H3,(H,12,13) SFAPWVZFUHJZIC-UHFFFAOYSA-N 50303491 8-methoxy-2-oxo-2H-chromene-3-carboxylic acid::CHEMBL568348 Carbonic anhydrase 4 Homo sapiens 31700 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303491&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 234562 104157852 CHEMBL568348 ZINC00084532 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906319 OCc1ccc2oc(=O)c(cc2c1)C(O)=O InChI=1S/C11H8O5/c12-5-6-1-2-9-7(3-6)4-8(10(13)14)11(15)16-9/h1-4,12H,5H2,(H,13,14) AESUZZDVQZTHIN-UHFFFAOYSA-N 50303490 6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylic acid::CHEMBL568417 Carbonic anhydrase 4 Homo sapiens 31300 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303490&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10632698 104157851 CHEMBL568417 ZINC45260390 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906320 COc1ccc2oc(=O)c(cc2c1)C(O)=O InChI=1S/C11H8O5/c1-15-7-2-3-9-6(4-7)5-8(10(12)13)11(14)16-9/h2-5H,1H3,(H,12,13) XIQQAIQZABTSNZ-UHFFFAOYSA-N 50303489 6-methoxy-2-oxo-2H-chromene-3-carboxylic acid::CHEMBL568416 Carbonic anhydrase 4 Homo sapiens >500000 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303489&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 711717 104157850 CHEMBL568416 ZINC00103684 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906321 Cc1ccc2oc(=O)c(cc2c1)C(O)=O InChI=1S/C11H8O4/c1-6-2-3-9-7(4-6)5-8(10(12)13)11(14)15-9/h2-5H,1H3,(H,12,13) FJICLQQBBFWGMZ-UHFFFAOYSA-N 50303488 6-methyl-2-oxo-2H-chromene-3-carboxylic acid::CHEMBL577123 Carbonic anhydrase 4 Homo sapiens 8500 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303488&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SH8 6SHI 25090 104157849 CHEMBL577123 ZINC02023765 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906322 OC(=O)c1cc2ccccc2oc1=O InChI=1S/C10H6O4/c11-9(12)7-5-6-3-1-2-4-8(6)14-10(7)13/h1-5H,(H,11,12) ACMLKANOGIVEPB-UHFFFAOYSA-N 50131066 2-Oxo-2H-chromene-3-carboxylic acid::CHEMBL83294 Carbonic anhydrase 4 Homo sapiens 9700 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131066&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10752 104022298 CHEMBL83294 ZINC00067688 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906323 COc1ccc2c(cc(=O)oc2c1)C(O)=O InChI=1S/C11H8O5/c1-15-6-2-3-7-8(11(13)14)5-10(12)16-9(7)4-6/h2-5H,1H3,(H,13,14) IHHLDCASADSHEG-UHFFFAOYSA-N 50022188 7-Methoxy-2-oxo-2H-chromene-4-carboxylic acid::CHEMBL12567 Carbonic anhydrase 4 Homo sapiens 26800 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022188&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44268050 103932811 CHEMBL12567 ZINC13548082 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50906324 O=c1ccc2ccc(CCc3ccccc3)cc2o1 InChI=1S/C17H14O2/c18-17-11-10-15-9-8-14(12-16(15)19-17)7-6-13-4-2-1-3-5-13/h1-5,8-12H,6-7H2 FQWWPSNGCTYUHH-UHFFFAOYSA-N 50303487 7-phenethoxy-2H-chromen-2-one::CHEMBL567544 Carbonic anhydrase 4 Homo sapiens 37400 ChEMBL 10.1021/jm901287j 10.7270/Q2MS3TP5 19911821 Maresca, A; Temperini, C; Pochet, L; Masereel, B; Scozzafava, A; Supuran, CT Universita degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303487&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 45485279 104157848 CHEMBL567544 ZINC45245162 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50904098 Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) FDDDEECHVMSUSB-UHFFFAOYSA-N 10857 4-aminobenzene-1-sulfonamide::CHEMBL21::Sulfanilamide::aromatic sulfonamide compound 5::aromatic/heteroaromatic sulfonamide 2::halogenosulfanilamide deriv. 5a Carbonic anhydrase 4 Homo sapiens 9760 ChEMBL 10.1021/jm901524f 10.7270/Q2PV6M96 20028100 Temperini, C; Innocenti, A; Scozzafava, A; Parkkila, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10857&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SAN 8BCB,1AJ0,4F93,4F92,4COQ,6RL9 5333 46511429 45373 CHEMBL21 DB00259 C07458 ZINC00002101 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50904111 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/jm901524f 10.7270/Q2PV6M96 20028100 Temperini, C; Innocenti, A; Scozzafava, A; Parkkila, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50904124 CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 KJADKKWYZYXHBB-XBWDGYHZSA-N 10887 Sulfamate 7::Topiramate (TPM)::US11535599, Example topiramate::[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate Carbonic anhydrase 4 Homo sapiens 4900 ChEMBL 10.1021/jm901524f 10.7270/Q2PV6M96 20028100 Temperini, C; Innocenti, A; Scozzafava, A; Parkkila, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10887&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TOR 3LXE,3HKU,5JNA 5284627 46511457 63631 DB00273 6849 C07502 ZINC01530804 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50904137 NS(=O)(=O)Cc1noc2ccccc12 InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12) UBQNRHZMVUUOMG-UHFFFAOYSA-N 10888 1,2-benzoxazol-3-ylmethanesulfonamide::CHEMBL750::SPR_2::US10172837, Zonisamide::Zonisamide::Zonisamide (ZNA)::Zonisamide (ZNS)::Zonisamide, 1::Zonisamide, ZNS Carbonic anhydrase 4 Homo sapiens 8590 ChEMBL 10.1021/jm901524f 10.7270/Q2PV6M96 20028100 Temperini, C; Innocenti, A; Scozzafava, A; Parkkila, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10888&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ZON 3PO7 5734 46511458 10127 CHEMBL750 DB00909 7047 C07504 ZINC00004321 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50904150 COc1cc2oc(=O)ccc2cc1[C@@H](O)CC(C)C InChI=1S/C15H18O4/c1-9(2)6-12(16)11-7-10-4-5-15(17)19-13(10)8-14(11)18-3/h4-5,7-9,12,16H,6H2,1-3H3/t12-/m0/s1 ZRXJDVGAMZQYJX-LBPRGKRZSA-N 50300203 (S)-6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one::6-(1S-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one::CHEMBL572366 Carbonic anhydrase 4 Homo sapiens 3800 ChEMBL 10.1021/jm901524f 10.7270/Q2PV6M96 20028100 Temperini, C; Innocenti, A; Scozzafava, A; Parkkila, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300203&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 45484187 104154564 CHEMBL572366 ZINC32236516 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50904163 COC[C@@H](NC(C)=O)C(=O)NCc1ccccc1 InChI=1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1 VPPJLAIAVCUEMN-GFCCVEGCSA-N 50300204 (2R)-2-acetylamino-N-benzyl-3-methoxypropanamide::(R)-2-Acetylamino-N-benzyl-3-methoxy-propionamide::(R)-2-acetamido-N-benzyl-3-methoxypropanamide::(R)-N-benzyl 2-acetamido-3-methoxypropionamide::(R)-N-benzyl 2-acetamido-3-methoxypropionamide,::CHEMBL58323::Erlosamide::LACOSAMIDE Carbonic anhydrase 4 Homo sapiens 525 ChEMBL 10.1021/jm901524f 10.7270/Q2PV6M96 20028100 Temperini, C; Innocenti, A; Scozzafava, A; Parkkila, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300204&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 219078 104154565 CHEMBL58323 DB06218 ZINC00007673 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50929812 Nc1oc2ccc(Cl)cc2c(=O)c1-c1ccc(Cl)cc1 InChI=1S/C15H9Cl2NO2/c16-9-3-1-8(2-4-9)13-14(19)11-7-10(17)5-6-12(11)20-15(13)18/h1-7H,18H2 YLWCNINLBDPMSO-UHFFFAOYSA-N 50381325 CHEMBL2019140 Carbonic anhydrase 4 Homo sapiens 3910 ChEMBL 10.1016/j.bmcl.2012.03.071 10.7270/Q2J1045T 22487176 Balboni, G; Congiu, C; Onnis, V; Maresca, A; Scozzafava, A; Winum, JY; Maietti, A; Supuran, CT Universit£ degli Studi di Cagliari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381325&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7463376 160860408 CHEMBL2019140 ZINC05031617 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50929858 Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1 InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+ LUKBXSAWLPMMSZ-OWOJBTEDSA-N 23926 (E)-resveratrol::5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol::CHEMBL165::Resveratol::Stilbene, 2f::cid_445154::resveratrol::trans-resveratrol Carbonic anhydrase 4 Homo sapiens 4010 ChEMBL 10.1016/j.bmcl.2012.03.071 10.7270/Q2J1045T 22487176 Balboni, G; Congiu, C; Onnis, V; Maresca, A; Scozzafava, A; Winum, JY; Maietti, A; Supuran, CT Universit£ degli Studi di Cagliari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23926&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search STL 6JEM,7WAQ,4QOH,4QOJ,5NZL,1U0W,3MNQ,7K1C,2L98,8ABT,4DPN,2YDX,5CR1,7Q9O,3CKL,1Z1F,1SG0,4PP6,1CGZ,5J54,7CCU,7KD8,4JAZ,1DVS,7CCW,3FTS,5U90,5BTR,4QER,2JIZ,7VB8,4HDA,4Q93 445154 53785926 27881 CHEMBL165 DB02709 C03582 ZINC00006787 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50929872 COc1ccc(cc1)-c1c(N)oc2ccc(Cl)cc2c1=O InChI=1S/C16H12ClNO3/c1-20-11-5-2-9(3-6-11)14-15(19)12-8-10(17)4-7-13(12)21-16(14)18/h2-8H,18H2,1H3 JMFKAVBWAOETEV-UHFFFAOYSA-N 50381319 CHEMBL2019143 Carbonic anhydrase 4 Homo sapiens 3600 ChEMBL 10.1016/j.bmcl.2012.03.071 10.7270/Q2J1045T 22487176 Balboni, G; Congiu, C; Onnis, V; Maresca, A; Scozzafava, A; Winum, JY; Maietti, A; Supuran, CT Universit£ degli Studi di Cagliari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381319&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 56921864 160860402 CHEMBL2019143 ZINC62716037 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941720 COc1c(Br)c(Br)c(CO)c(Br)c1OC InChI=1S/C9H9Br3O3/c1-14-8-6(11)4(3-13)5(10)7(12)9(8)15-2/h13H,3H2,1-2H3 VUMVVGRIGBOUHZ-UHFFFAOYSA-N 50363490 CHEMBL1946180::hCA inhibitor, 8 Carbonic anhydrase 4 Homo sapiens 46350 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363490&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57397664 136967552 CHEMBL1946180 ZINC14769547 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941728 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 578 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941729 COc1cc(Cc2c(OC)c(Br)c(OC)c(Br)c2OC)c(Br)c(Br)c1OC InChI=1S/C18H18Br4O5/c1-23-10-7-8(11(19)12(20)17(10)26-4)6-9-15(24-2)13(21)18(27-5)14(22)16(9)25-3/h7H,6H2,1-5H3 GEOLICWGMIJJFZ-UHFFFAOYSA-N 50386174 CHEMBL2042371 Carbonic anhydrase 4 Homo sapiens 45740 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386174&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 23426698 160865257 CHEMBL2042371 ZINC84712512 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941730 COc1cc(OC)c(Cc2cc(OC)c(OC)c(Br)c2Br)c(OC)c1Br InChI=1S/C18H19Br3O5/c1-22-11-8-12(23-2)15(20)17(25-4)10(11)6-9-7-13(24-3)18(26-5)16(21)14(9)19/h7-8H,6H2,1-5H3 FLLBNCATQDNXFH-UHFFFAOYSA-N 50386167 CHEMBL2042370 Carbonic anhydrase 4 Homo sapiens 42260 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386167&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 66572313 160865250 CHEMBL2042370 ZINC84652069 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941731 Oc1cc(Cc2c(O)c(Br)c(O)c(Cc3cc(O)c(O)c(Br)c3Br)c2O)c(Br)c(Br)c1O InChI=1S/C20H13Br5O7/c21-11-5(3-9(26)19(31)13(11)23)1-7-16(28)8(18(30)15(25)17(7)29)2-6-4-10(27)20(32)14(24)12(6)22/h3-4,26-32H,1-2H2 KNHOTGMNAPTUGT-UHFFFAOYSA-N 50386175 VIDALOL B Carbonic anhydrase 4 Homo sapiens 1840 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386175&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 132037 160865258 ZINC95615529 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941732 COc1cc(Cc2c(OC)c(Br)c(OC)c(Cc3cc(OC)c(OC)c(Br)c3Br)c2OC)c(Br)c(Br)c1OC InChI=1S/C27H27Br5O7/c1-33-16-10-12(18(28)20(30)26(16)38-6)8-14-23(35-3)15(25(37-5)22(32)24(14)36-4)9-13-11-17(34-2)27(39-7)21(31)19(13)29/h10-11H,8-9H2,1-7H3 SSGKSCGDZLLLIZ-UHFFFAOYSA-N 50386176 CHEMBL2040866 Carbonic anhydrase 4 Homo sapiens 57610 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386176&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 66573254 160865259 CHEMBL2040866 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941733 COc1ccc(cc1OC)C(O)=O InChI=1S/C9H10O4/c1-12-7-4-3-6(9(10)11)5-8(7)13-2/h3-5H,1-2H3,(H,10,11) DAUAQNGYDSHRET-UHFFFAOYSA-N 50336487 3,4-Dimethoxy-benzoic acid::3,4-dimethoxybenzoic acid::CHEMBL118903 Carbonic anhydrase 4 Homo sapiens 6480 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50336487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50336487&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TWO 4EGN 7121 125086589 296881 CHEMBL118903 ZINC00392017 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941734 OC(=O)c1ccc(O)c(O)c1 InChI=1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11) YQUVCSBJEUQKSH-UHFFFAOYSA-N 50100861 3,4-Dihydroxybenzoate, VIII::3,4-dihydroxybenzoic acid::4,5-Dihydroxybenzoic acid::4-Carboxy-1,2-dihydroxybenzene::CHEMBL37537::Protocatechuic acid::Protocatechuic acid (M1)::Protocatehuic acid::cid_72 Carbonic anhydrase 4 Homo sapiens 2450 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100861&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search DHB 2BUV,1N8Q,6QHN,1PHH,4J0I,3O5U,4FHT,1YKP,1YKN,3LMX,3HKP,4EYK,2BSL,3WRC,3DX5,6JU1,3PCA,7CVX,1B4U,1YKL,5FAN,4RGX,4PAF,3MV6,2BV0,7EQV,1EOB,5X1M,5X1N,6S33 72 103997589 36062 CHEMBL37537 DB03946 C00230 ZINC00013246 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941735 COc1ccccc1 InChI=1S/C7H8O/c1-8-7-5-3-2-4-6-7/h2-6H,1H3 RDOXTESZEPMUJZ-UHFFFAOYSA-N 50386177 ANISOLE Carbonic anhydrase 4 Homo sapiens 14320 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386177&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7519 160865260 16579 C01403 ZINC00897131 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941736 Oc1c(O)c(Br)c(Br)c(Br)c1Br InChI=1S/C6H2Br4O2/c7-1-2(8)4(10)6(12)5(11)3(1)9/h11-12H OAUWOBSDSJNJQP-UHFFFAOYSA-N 50386168 TETRABROMOCATECHOL::hCA inhibitor, 7 Carbonic anhydrase 4 Homo sapiens 17480 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386168&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 61127 160865251 52879 ZINC00638437 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941737 Oc1c(O)c(Br)c(Br)cc1Br InChI=1S/C6H3Br3O2/c7-2-1-3(8)5(10)6(11)4(2)9/h1,10-11H IGIRETJJHMVFCS-UHFFFAOYSA-N 50386169 CHEMBL2042369::hCA inhibitor, 6 Carbonic anhydrase 4 Homo sapiens 13120 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386169&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 70696540 160865252 52879 CHEMBL2042369 ZINC84708383 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941738 COc1c(Br)cc(Br)c(Br)c1OC InChI=1S/C8H7Br3O2/c1-12-7-5(10)3-4(9)6(11)8(7)13-2/h3H,1-2H3 RLQZRYRMTTWFCU-UHFFFAOYSA-N 50363489 CHEMBL1946179::hCA inhibitor, 9 Carbonic anhydrase 4 Homo sapiens 48730 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363489&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 57399336 136967551 CHEMBL1946179 ZINC82157002 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941739 Oc1ccc(Cc2ccc(O)c(O)c2)cc1O InChI=1S/C13H12O4/c14-10-3-1-8(6-12(10)16)5-9-2-4-11(15)13(17)7-9/h1-4,6-7,14-17H,5H2 GGOBECRWBXYXEY-UHFFFAOYSA-N 50386171 CHEMBL253691::hCA inhibitor, 5 Carbonic anhydrase 4 Homo sapiens 7640 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386171&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10059806 160865254 CHEMBL253691 ZINC28979752 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941740 COc1c(Br)cc(Cc2c(Br)c(Br)c(OC)c(OC)c2Br)c(Br)c1OC InChI=1S/C17H15Br5O4/c1-23-14-9(18)6-7(10(19)15(14)24-2)5-8-11(20)13(22)17(26-4)16(25-3)12(8)21/h6H,5H2,1-4H3 RBBCOIXYLPMIEQ-UHFFFAOYSA-N 50386172 CHEMBL2042368 Carbonic anhydrase 4 Homo sapiens 30780 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386172&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 70692438 160865255 CHEMBL2042368 ZINC84654553 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941741 COc1c(Br)c(Br)c(Cc2c(Br)c(Br)c(OC)c(OC)c2Br)c(Br)c1OC InChI=1S/C17H14Br6O4/c1-24-14-10(20)6(8(18)12(22)16(14)26-3)5-7-9(19)13(23)17(27-4)15(25-2)11(7)21/h5H2,1-4H3 PGGHXQFHMLFNKM-UHFFFAOYSA-N 50386173 CHEMBL2016670 Carbonic anhydrase 4 Homo sapiens 32720 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386173&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 53307609 160865256 CHEMBL2016670 ZINC95550841 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50941770 COc1ccc(Cc2ccc(OC)c(OC)c2)cc1OC InChI=1S/C17H20O4/c1-18-14-7-5-12(10-16(14)20-3)9-13-6-8-15(19-2)17(11-13)21-4/h5-8,10-11H,9H2,1-4H3 XEGVJXFCBVQOPB-UHFFFAOYSA-N 50386170 CHEMBL2016664::hCA inhibitor, 4 Carbonic anhydrase 4 Homo sapiens 145120 ChEMBL 10.1016/j.ejmech.2012.05.025 10.7270/Q2WS8V91 22687439 Balaydin, HT; Senturk, M; Goksu, S; Menzek, A Atat£rk University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386170&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 284045 160865253 CHEMBL2016664 ZINC01871861 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50973160 Cc1ccc2-c3c(CSc2n1)cnn3-c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H14N4O2S2/c1-10-2-7-14-15-11(9-23-16(14)19-10)8-18-20(15)12-3-5-13(6-4-12)24(17,21)22/h2-8H,9H2,1H3,(H2,17,21,22) BBYVQBNYXZIDGW-UHFFFAOYSA-N 50399075 CHEMBL2179304 Carbonic anhydrase 4 Homo sapiens 7500 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399075&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IE2 3QYK 56684131 163348099 CHEMBL2179304 ZINC95578669 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50973175 NS(=O)(=O)c1ccc(cc1)-n1ncc2CSc3ncccc3-c12 InChI=1S/C15H12N4O2S2/c16-23(20,21)12-5-3-11(4-6-12)19-14-10(8-18-19)9-22-15-13(14)2-1-7-17-15/h1-8H,9H2,(H2,16,20,21) HLIMRHGQWNYSKN-UHFFFAOYSA-N 50399076 CHEMBL2179305 Carbonic anhydrase 4 Homo sapiens 328 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399076&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71450117 163348100 CHEMBL2179305 ZINC95573411 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50973190 NS(=O)(=O)c1ccc(cc1)-n1ncc2CSc3cc(ccc3-c12)C(F)(F)F InChI=1S/C17H12F3N3O2S2/c18-17(19,20)11-1-6-14-15(7-11)26-9-10-8-22-23(16(10)14)12-2-4-13(5-3-12)27(21,24)25/h1-8H,9H2,(H2,21,24,25) UIWAHXLXRURYJZ-UHFFFAOYSA-N 50399077 CHEMBL2179306 Carbonic anhydrase 4 Homo sapiens 7140 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399077&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71455488 163348101 CHEMBL2179306 ZINC95575122 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50973205 NS(=O)(=O)c1ccc(cc1)-n1ncc2CSc3cc(Cl)ccc3-c12 InChI=1S/C16H12ClN3O2S2/c17-11-1-6-14-15(7-11)23-9-10-8-19-20(16(10)14)12-2-4-13(5-3-12)24(18,21)22/h1-8H,9H2,(H2,18,21,22) OEZYKWLLDKHTRE-UHFFFAOYSA-N 50399078 CHEMBL2179307 Carbonic anhydrase 4 Homo sapiens 7200 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399078&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71457274 163348102 CHEMBL2179307 ZINC95573441 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50973220 COc1ccc2-c3c(CSc2c1)cnn3-c1ccc(cc1)S(N)(=O)=O InChI=1S/C17H15N3O3S2/c1-23-13-4-7-15-16(8-13)24-10-11-9-19-20(17(11)15)12-2-5-14(6-3-12)25(18,21)22/h2-9H,10H2,1H3,(H2,18,21,22) DMXTVXWEGNJBRF-UHFFFAOYSA-N 50399079 CHEMBL2179308 Carbonic anhydrase 4 Homo sapiens 8850 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399079&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71455489 163348103 CHEMBL2179308 ZINC95572827 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50973235 Cc1onc(c1-c1ccc(cc1)S(N)(=O)=O)-c1ccccc1 InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20) LNPDTQAFDNKSHK-UHFFFAOYSA-N 13063 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonamide::Bextra::CHEMBL865::VLX::Valdecoxib::cid_119607 Carbonic anhydrase 4 Homo sapiens 1340 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13063&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search COX 2AW1 119607 46513481 63634 CHEMBL865 DB00580 2894 ZINC00006694 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50973250 Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) RZEKVGVHFLEQIL-UHFFFAOYSA-N 11639 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide::CHEMBL118::CLX::Celebrex::Celecoxib::US10322118, Urea-Based Scaffold Entry 9::US11478464, Compound Celecoxib::US8741944, Comparative Compound::US9388139, Celecoxib::cid_2662 Carbonic anhydrase 4 Homo sapiens 880 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11639&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CEL 3LN1,3KK6,5JW1,7ZEJ,4FIM,1OQ5 2662 46512162 41423 CHEMBL118 DB00482 2892 C07589 ZINC02570895 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51050030 OC[C@H]1O[C@@H](CC(=O)C=Cc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C16H20O7/c17-8-13-15(21)16(22)14(20)12(23-13)7-11(19)6-3-9-1-4-10(18)5-2-9/h1-6,12-18,20-22H,7-8H2/t12-,13+,14-,15-,16+/m0/s1 CRGUBQLNLWTCPK-XFIYOXNOSA-N 50426823 CHEMBL2323140 Carbonic anhydrase 4 Homo sapiens 7100 ChEMBL 10.1016/j.bmc.2012.09.002 10.7270/Q2D21ZZJ 23010455 Riafrecha, LE; Rodriguez, OM; Vullo, D; Supuran, CT; Colinas, PA Universidad Nacional de La Plata http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426823&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71521576 164155698 CHEMBL2323140 ZINC95582222 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51050042 OC[C@H]1O[C@@H](CC(=O)C=Cc2cccc(O)c2)[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C16H20O7/c17-8-13-15(21)16(22)14(20)12(23-13)7-11(19)5-4-9-2-1-3-10(18)6-9/h1-6,12-18,20-22H,7-8H2/t12-,13+,14-,15+,16+/m0/s1 AKXOYOOJKIDBRC-ZVDSWSACSA-N 50426825 CHEMBL2323138 Carbonic anhydrase 4 Homo sapiens 8300 ChEMBL 10.1016/j.bmc.2012.09.002 10.7270/Q2D21ZZJ 23010455 Riafrecha, LE; Rodriguez, OM; Vullo, D; Supuran, CT; Colinas, PA Universidad Nacional de La Plata http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426825&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71521496 164155700 CHEMBL2323138 ZINC95582164 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51050054 CC(=O)OC[C@H]1O[C@@H](CC(=O)C=Cc2ccc(O)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C24H28O11/c1-13(25)31-12-21-23(33-15(3)27)24(34-16(4)28)22(32-14(2)26)20(35-21)11-19(30)10-7-17-5-8-18(29)9-6-17/h5-10,20-24,29H,11-12H2,1-4H3/t20-,21+,22-,23-,24+/m0/s1 BVSYFLLFDCLRSV-VHJOFQCFSA-N 50426826 CHEMBL2323137 Carbonic anhydrase 4 Homo sapiens 6700 ChEMBL 10.1016/j.bmc.2012.09.002 10.7270/Q2D21ZZJ 23010455 Riafrecha, LE; Rodriguez, OM; Vullo, D; Supuran, CT; Colinas, PA Universidad Nacional de La Plata http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426826&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71521495 164155701 CHEMBL2323137 ZINC95584546 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51050060 OC[C@H]1O[C@@H](CC(=O)C=Cc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C16H20O7/c17-8-13-15(21)16(22)14(20)12(23-13)7-11(19)6-3-9-1-4-10(18)5-2-9/h1-6,12-18,20-22H,7-8H2/t12-,13+,14-,15-,16+/m0/s1 CRGUBQLNLWTCPK-XFIYOXNOSA-N 50426823 CHEMBL2323140 Carbonic anhydrase 4 Homo sapiens 8400 ChEMBL 10.1016/j.bmc.2012.09.002 10.7270/Q2D21ZZJ 23010455 Riafrecha, LE; Rodriguez, OM; Vullo, D; Supuran, CT; Colinas, PA Universidad Nacional de La Plata http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426823&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71521576 164155698 CHEMBL2323140 ZINC95582222 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51050072 OC[C@H]1O[C@@H](CC(=O)C=Cc2cccc(O)c2)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C16H20O7/c17-8-13-15(21)16(22)14(20)12(23-13)7-11(19)5-4-9-2-1-3-10(18)6-9/h1-6,12-18,20-22H,7-8H2/t12-,13+,14-,15-,16+/m0/s1 AKXOYOOJKIDBRC-XFIYOXNOSA-N 50426824 CHEMBL2323139 Carbonic anhydrase 4 Homo sapiens 9200 ChEMBL 10.1016/j.bmc.2012.09.002 10.7270/Q2D21ZZJ 23010455 Riafrecha, LE; Rodriguez, OM; Vullo, D; Supuran, CT; Colinas, PA Universidad Nacional de La Plata http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426824&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71521497 164155699 CHEMBL2323139 ZINC95583609 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51050091 Oc1ccccc1 InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H ISWSIDIOOBJBQZ-UHFFFAOYSA-N 26187 α-CA inhibitor, 11::CHEMBL14060::US9688816, 2::phenol Carbonic anhydrase 4 Homo sapiens 9500 ChEMBL 10.1016/j.bmc.2012.09.002 10.7270/Q2D21ZZJ 23010455 Riafrecha, LE; Rodriguez, OM; Vullo, D; Supuran, CT; Colinas, PA Universidad Nacional de La Plata http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26187&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search IPH 2PZV,3NX8,1XDA,4OLA,1MPJ,1PN0,5HPU,7AT0,1XW7,3AIY,3NC0,5USS,1JHY,1JHX,1WAV,2OMB,2OMN,3ROV,1FOH,5KI6,4W5Q,4W5R,4W5T,4W5N,1Q4V,4W5O,5URU,5JS1,5JS2,3ZS2,1XU5,6IY8,1AIY,5UU4,5UU3,6MFN,6MFR,1LI2,3Q3O,7JP3,3V1G,3V19,3JSD,5AIY,6Q7S,4A71,5FRW,2OLD,3ZQR,6TYH,3KQ6,3P2X,4JMW,5KBE,2WS6,2WS7,2J9N,1ZNJ,6MDZ,5ILG,1V03,7WDG,7WDH,1RWE,3KMH,4Z4F,4Z4G,4Z4D,4Z4E,4Z4C,4Z4H,4Z4I,1QIY,5BQQ,4F3T,1ZEG,6CK2,5W3R,4AIY,7VQF,1FJW,3GKY,4P65,5NQ8,1W8P,3U3E,5EMS,4AJZ,5T7B,3F39,4H07,4I7L,1AI0,1AI7,4AKJ,2AIY,2VE7,5HRQ,3GUO,5UDP,5WEA,4HDS,5UQA,2AS3,3P33,1LPH,6Z44 996 56464624 15882 CHEMBL14060 DB03255 C00146 ZINC05133329 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51050109 CC(=O)OC[C@H]1O[C@@H](CC(=O)C=Cc2cccc(O)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C24H28O11/c1-13(25)31-12-21-23(33-15(3)27)24(34-16(4)28)22(32-14(2)26)20(35-21)11-19(30)9-8-17-6-5-7-18(29)10-17/h5-10,20-24,29H,11-12H2,1-4H3/t20-,21+,22-,23-,24+/m0/s1 AABXXZMFZZDFMA-VHJOFQCFSA-N 50426827 CHEMBL2323136 Carbonic anhydrase 4 Homo sapiens 7800 ChEMBL 10.1016/j.bmc.2012.09.002 10.7270/Q2D21ZZJ 23010455 Riafrecha, LE; Rodriguez, OM; Vullo, D; Supuran, CT; Colinas, PA Universidad Nacional de La Plata http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426827&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71521494 164155702 CHEMBL2323136 ZINC95584579 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51050121 CC(=O)OC[C@H]1O[C@@H](CC(=O)C=Cc2ccc(O)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O InChI=1S/C24H28O11/c1-13(25)31-12-21-23(33-15(3)27)24(34-16(4)28)22(32-14(2)26)20(35-21)11-19(30)10-7-17-5-8-18(29)9-6-17/h5-10,20-24,29H,11-12H2,1-4H3/t20-,21+,22-,23+,24+/m0/s1 BVSYFLLFDCLRSV-OEYYQIPYSA-N 50426828 CHEMBL2323135 Carbonic anhydrase 4 Homo sapiens 4900 ChEMBL 10.1016/j.bmc.2012.09.002 10.7270/Q2D21ZZJ 23010455 Riafrecha, LE; Rodriguez, OM; Vullo, D; Supuran, CT; Colinas, PA Universidad Nacional de La Plata http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426828&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71521493 164155703 CHEMBL2323135 ZINC95583681 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51050133 CC(=O)OC[C@H]1O[C@@H](CC(=O)C=Cc2cccc(O)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O InChI=1S/C24H28O11/c1-13(25)31-12-21-23(33-15(3)27)24(34-16(4)28)22(32-14(2)26)20(35-21)11-19(30)9-8-17-6-5-7-18(29)10-17/h5-10,20-24,29H,11-12H2,1-4H3/t20-,21+,22-,23+,24+/m0/s1 AABXXZMFZZDFMA-OEYYQIPYSA-N 50426829 CHEMBL2323134 Carbonic anhydrase 4 Homo sapiens 5600 ChEMBL 10.1016/j.bmc.2012.09.002 10.7270/Q2D21ZZJ 23010455 Riafrecha, LE; Rodriguez, OM; Vullo, D; Supuran, CT; Colinas, PA Universidad Nacional de La Plata http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426829&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71521575 164155704 CHEMBL2323134 ZINC95584063 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536810 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2ccc(cc2)-c2nnn[nH]2)C(=O)CC(C)(C)C1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C30H32N6O4S/c1-29(2)13-21-26(23(37)15-29)25(17-5-7-18(8-6-17)28-32-34-35-33-28)27-22(14-30(3,4)16-24(27)38)36(21)19-9-11-20(12-10-19)41(31,39)40/h5-12,25H,13-16H2,1-4H3,(H2,31,39,40)(H,32,33,34,35) XHXARUOKKJEWLI-UHFFFAOYSA-N 50205563 CHEMBL3969810 Carbonic anhydrase 4 Homo sapiens 7301 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205563&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134153199 375980842 CHEMBL3969810 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536815 CC1(C)CC(=O)C2=C(C1)OC(N)=C(C#N)C2c1ccc(cc1)-c1nnn[nH]1 InChI=1S/C19H18N6O2/c1-19(2)7-13(26)16-14(8-19)27-17(21)12(9-20)15(16)10-3-5-11(6-4-10)18-22-24-25-23-18/h3-6,15H,7-8,21H2,1-2H3,(H,22,23,24,25) MXXHAOFWHDYGRH-UHFFFAOYSA-N 50205564 CHEMBL3908650 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205564&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134132041 375980843 CHEMBL3908650 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536816 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2cccc(c2)-c2nnn[nH]2)C(=O)CC(C)(C)C1)c1ccc(cc1)C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C37H37N7O5S/c1-36(2)17-27-32(29(45)19-36)31(22-6-5-7-23(16-22)34-40-42-43-41-34)33-28(18-37(3,4)20-30(33)46)44(27)25-12-8-21(9-13-25)35(47)39-24-10-14-26(15-11-24)50(38,48)49/h5-16,31H,17-20H2,1-4H3,(H,39,47)(H2,38,48,49)(H,40,41,42,43) AKNVQZOTJMDENQ-UHFFFAOYSA-N 50205568 CHEMBL3937384 Carbonic anhydrase 4 Homo sapiens 2791 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205568&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134148709 375980847 CHEMBL3937384 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536817 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536837 CC1(C)CC(=O)C2=C(C1)OC(N)=C(C#N)C2c1cccc(c1)-c1nnn[nH]1 InChI=1S/C19H18N6O2/c1-19(2)7-13(26)16-14(8-19)27-17(21)12(9-20)15(16)10-4-3-5-11(6-10)18-22-24-25-23-18/h3-6,15H,7-8,21H2,1-2H3,(H,22,23,24,25) LASZWTBSZNSJOT-UHFFFAOYSA-N 50205572 CHEMBL3979000 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205572&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134151823 375980851 CHEMBL3979000 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536872 O=Cc1cccc(c1)-c1nnn[nH]1 InChI=1S/C8H6N4O/c13-5-6-2-1-3-7(4-6)8-9-11-12-10-8/h1-5H,(H,9,10,11,12) GWZICMAGCVWLAY-UHFFFAOYSA-N 50205573 CHEMBL3938481 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205573&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10535227 375980852 CHEMBL3938481 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536873 O=Cc1ccc(cc1)-c1nnn[nH]1 InChI=1S/C8H6N4O/c13-5-6-1-3-7(4-2-6)8-9-11-12-10-8/h1-5H,(H,9,10,11,12) SRGPTCYCHZMFOR-UHFFFAOYSA-N 50205567 CHEMBL3910545 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205567&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2760606 375980846 CHEMBL3910545 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536880 NC1=C(C#N)C(C2=C(CCCC2=O)O1)c1ccc(cc1)-c1nnn[nH]1 InChI=1S/C17H14N6O2/c18-8-11-14(15-12(24)2-1-3-13(15)25-16(11)19)9-4-6-10(7-5-9)17-20-22-23-21-17/h4-7,14H,1-3,19H2,(H,20,21,22,23) LMQLKVZHTLWWKA-UHFFFAOYSA-N 50205597 CHEMBL3917590 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205597&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134143174 104083928 CHEMBL3917590 ZINC28650619 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536881 NC1=C(C#N)C(C2=C(CCCC2=O)O1)c1cccc(c1)-c1nnn[nH]1 InChI=1S/C17H14N6O2/c18-8-11-14(15-12(24)5-2-6-13(15)25-16(11)19)9-3-1-4-10(7-9)17-20-22-23-21-17/h1,3-4,7,14H,2,5-6,19H2,(H,20,21,22,23) HGQVGXMNRILLFR-UHFFFAOYSA-N 50205596 CHEMBL3889560 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205596&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134130639 104083927 CHEMBL3889560 ZINC28650626 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536885 CC1(C)CC(=O)C2=C(C1)OC1=C(C2c2cccc(c2)-c2nnn[nH]2)C(=O)CC(C)(C)C1 InChI=1S/C24H26N4O3/c1-23(2)9-15(29)20-17(11-23)31-18-12-24(3,4)10-16(30)21(18)19(20)13-6-5-7-14(8-13)22-25-27-28-26-22/h5-8,19H,9-12H2,1-4H3,(H,25,26,27,28) TYPJSHHMDMXQCS-UHFFFAOYSA-N 50205598 CHEMBL3959700 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205598&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134154945 104083929 CHEMBL3959700 ZINC28650728 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536886 NS(=O)(=O)c1ccc(cc1)N1C2=C(C(C3=C1CCCC3=O)c1cccc(c1)-c1nnn[nH]1)C(=O)CCC2 InChI=1S/C26H24N6O4S/c27-37(35,36)18-12-10-17(11-13-18)32-19-6-2-8-21(33)24(19)23(25-20(32)7-3-9-22(25)34)15-4-1-5-16(14-15)26-28-30-31-29-26/h1,4-5,10-14,23H,2-3,6-9H2,(H2,27,35,36)(H,28,29,30,31) NPJSGQUPFYPHPF-UHFFFAOYSA-N 50205595 CHEMBL3955992 Carbonic anhydrase 4 Homo sapiens 6056 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205595&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134144756 104083926 CHEMBL3955992 ZINC28650720 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536889 O=C1CCCC2=C1C(C1=C(CCCC1=O)O2)c1ccc(cc1)-c1nnn[nH]1 InChI=1S/C20H18N4O3/c25-13-3-1-5-15-18(13)17(19-14(26)4-2-6-16(19)27-15)11-7-9-12(10-8-11)20-21-23-24-22-20/h7-10,17H,1-6H2,(H,21,22,23,24) LVGQVJNALGOCQX-UHFFFAOYSA-N 50205574 CHEMBL3950179 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205574&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134147016 375980853 CHEMBL3950179 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536891 CC1(C)CC(=O)C2=C(C1)OC1=C(C2c2ccc(cc2)-c2nnn[nH]2)C(=O)CC(C)(C)C1 InChI=1S/C24H26N4O3/c1-23(2)9-15(29)20-17(11-23)31-18-12-24(3,4)10-16(30)21(18)19(20)13-5-7-14(8-6-13)22-25-27-28-26-22/h5-8,19H,9-12H2,1-4H3,(H,25,26,27,28) FYVFQOXACSEFJJ-UHFFFAOYSA-N 50205565 CHEMBL3890627 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205565&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134137004 375980844 CHEMBL3890627 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536900 NS(=O)(=O)c1ccc(cc1)N1C2=C(C(C3=C1CCCC3=O)c1ccc(cc1)-c1nnn[nH]1)C(=O)CCC2 InChI=1S/C26H24N6O4S/c27-37(35,36)18-13-11-17(12-14-18)32-19-3-1-5-21(33)24(19)23(25-20(32)4-2-6-22(25)34)15-7-9-16(10-8-15)26-28-30-31-29-26/h7-14,23H,1-6H2,(H2,27,35,36)(H,28,29,30,31) SWROSRFYNBHBAT-UHFFFAOYSA-N 50205569 CHEMBL3928382 Carbonic anhydrase 4 Homo sapiens 7345 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205569&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134140936 375980848 CHEMBL3928382 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536907 O=C1CCCC2=C1C(C1=C(CCCC1=O)O2)c1cccc(c1)-c1nnn[nH]1 InChI=1S/C20H18N4O3/c25-13-6-2-8-15-18(13)17(19-14(26)7-3-9-16(19)27-15)11-4-1-5-12(10-11)20-21-23-24-22-20/h1,4-5,10,17H,2-3,6-9H2,(H,21,22,23,24) BKCNTOPNOFFMGH-UHFFFAOYSA-N 50205570 CHEMBL3970750 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205570&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134153525 375980849 CHEMBL3970750 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536908 NS(=O)(=O)c1ccc(NC(=O)c2ccc(cc2)N2C3=C(C(C4=C2CCCC4=O)c2cccc(c2)-c2nnn[nH]2)C(=O)CCC3)cc1 InChI=1S/C33H29N7O5S/c34-46(44,45)24-16-12-22(13-17-24)35-33(43)19-10-14-23(15-11-19)40-25-6-2-8-27(41)30(25)29(31-26(40)7-3-9-28(31)42)20-4-1-5-21(18-20)32-36-38-39-37-32/h1,4-5,10-18,29H,2-3,6-9H2,(H,35,43)(H2,34,44,45)(H,36,37,38,39) XFGFNNUMJQYGIQ-UHFFFAOYSA-N 50205571 CHEMBL3967103 Carbonic anhydrase 4 Homo sapiens 2485 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205571&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134149835 375980850 CHEMBL3967103 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50536910 CC1(C)CC(=O)C2=C(C1)N(C1=C(C2c2cccc(c2)-c2nnn[nH]2)C(=O)CC(C)(C)C1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C30H32N6O4S/c1-29(2)13-21-26(23(37)15-29)25(17-6-5-7-18(12-17)28-32-34-35-33-28)27-22(14-30(3,4)16-24(27)38)36(21)19-8-10-20(11-9-19)41(31,39)40/h5-12,25H,13-16H2,1-4H3,(H2,31,39,40)(H,32,33,34,35) DFEKSBWCZUIYBM-UHFFFAOYSA-N 50205566 CHEMBL3947267 Carbonic anhydrase 4 Homo sapiens 8489 ChEMBL 10.1016/j.bmcl.2016.11.028 10.7270/Q25D8TT1 27876475 Esirden, I; Tanç, M; Supuran, CT; Kaya, M Dumlupinar University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50205566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50205566&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134147261 375980845 CHEMBL3947267 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50554920 Nc1onc(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1ccc(F)cc1 InChI=1S/C16H13FN4O4S/c17-10-3-1-9(2-4-10)14-13(15(18)25-21-14)16(22)20-11-5-7-12(8-6-11)26(19,23)24/h1-8H,18H2,(H,20,22)(H2,19,23,24) IYHFLOKFAYJIGD-UHFFFAOYSA-N 50211511 CHEMBL3969743 Carbonic anhydrase 4 Homo sapiens 442 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211511&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134153506 375983002 CHEMBL3969743 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50554921 NS(=O)(=O)c1ccc(NC(=O)c2c(NC(=O)c3ccc(cc3)[N+]([O-])=O)onc2-c2c(Cl)cccc2Cl)cc1 InChI=1S/C23H15Cl2N5O7S/c24-16-2-1-3-17(25)18(16)20-19(22(32)27-13-6-10-15(11-7-13)38(26,35)36)23(37-29-20)28-21(31)12-4-8-14(9-5-12)30(33)34/h1-11H,(H,27,32)(H,28,31)(H2,26,35,36) AYWVQZXYBROZGY-UHFFFAOYSA-N 50211512 CHEMBL3982616 Carbonic anhydrase 4 Homo sapiens 305 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211512&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134156655 375983003 CHEMBL3982616 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50554922 NS(=O)(=O)c1ccc(NC(=O)c2c(NC(=O)c3ccccc3)onc2-c2c(Cl)cccc2Cl)cc1 InChI=1S/C23H16Cl2N4O5S/c24-16-7-4-8-17(25)18(16)20-19(22(31)27-14-9-11-15(12-10-14)35(26,32)33)23(34-29-20)28-21(30)13-5-2-1-3-6-13/h1-12H,(H,27,31)(H,28,30)(H2,26,32,33) XCMWGESLCUAXCF-UHFFFAOYSA-N 50211513 CHEMBL3936291 Carbonic anhydrase 4 Homo sapiens 444 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211513&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134149271 375983004 CHEMBL3936291 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50554932 NS(=O)(=O)c1ccc(NC(=O)c2c(NC(=O)c3ccc(Br)cc3)onc2-c2ccc(Cl)cc2Cl)cc1 InChI=1S/C23H15BrCl2N4O5S/c24-13-3-1-12(2-4-13)21(31)29-23-19(20(30-35-23)17-10-5-14(25)11-18(17)26)22(32)28-15-6-8-16(9-7-15)36(27,33)34/h1-11H,(H,28,32)(H,29,31)(H2,27,33,34) MFRQVEDUESBTOV-UHFFFAOYSA-N 50211591 CHEMBL3890026 Carbonic anhydrase 4 Homo sapiens 372 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211591&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134130817 375983008 CHEMBL3890026 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50554934 NS(=O)(=O)c1ccc(NC(=O)c2c(NC(=O)c3ccc(Br)cc3)onc2-c2c(Cl)cccc2Cl)cc1 InChI=1S/C23H15BrCl2N4O5S/c24-13-6-4-12(5-7-13)21(31)29-23-19(20(30-35-23)18-16(25)2-1-3-17(18)26)22(32)28-14-8-10-15(11-9-14)36(27,33)34/h1-11H,(H,28,32)(H,29,31)(H2,27,33,34) NPVOXKAHHDJLNY-UHFFFAOYSA-N 50211595 CHEMBL3918390 Carbonic anhydrase 4 Homo sapiens 108 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211595&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134139215 375983012 CHEMBL3918390 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50554936 Nc1onc(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1ccccc1 InChI=1S/C16H14N4O4S/c17-15-13(14(20-24-15)10-4-2-1-3-5-10)16(21)19-11-6-8-12(9-7-11)25(18,22)23/h1-9H,17H2,(H,19,21)(H2,18,22,23) IEQOYPCYLZVGPL-UHFFFAOYSA-N 50211596 CHEMBL3978103 Carbonic anhydrase 4 Homo sapiens 451 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211596&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134152087 375983013 CHEMBL3978103 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50554953 COc1cc(Cl)c(cc1OC)-c1noc(NC(=O)c2ccc(cc2)[N+]([O-])=O)c1C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C25H20ClN5O9S/c1-38-19-11-17(18(26)12-20(19)39-2)22-21(24(33)28-14-5-9-16(10-6-14)41(27,36)37)25(40-30-22)29-23(32)13-3-7-15(8-4-13)31(34)35/h3-12H,1-2H3,(H,28,33)(H,29,32)(H2,27,36,37) KBWPBLKBJVATAL-UHFFFAOYSA-N 50211592 CHEMBL3966126 Carbonic anhydrase 4 Homo sapiens 2397 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211592&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134149815 375983009 CHEMBL3966126 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50554965 Nc1onc(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1ccc(Br)cc1 InChI=1S/C16H13BrN4O4S/c17-10-3-1-9(2-4-10)14-13(15(18)25-21-14)16(22)20-11-5-7-12(8-6-11)26(19,23)24/h1-8H,18H2,(H,20,22)(H2,19,23,24) QLUSYRMWCOICRS-UHFFFAOYSA-N 50211589 CHEMBL3898548 Carbonic anhydrase 4 Homo sapiens 286 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211589&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134133785 375983006 CHEMBL3898548 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50554966 Nc1onc(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1ccc(cc1)[N+]([O-])=O InChI=1S/C16H13N5O6S/c17-15-13(14(20-27-15)9-1-5-11(6-2-9)21(23)24)16(22)19-10-3-7-12(8-4-10)28(18,25)26/h1-8H,17H2,(H,19,22)(H2,18,25,26) WFALAHLDCCYRAJ-UHFFFAOYSA-N 50211600 CHEMBL3907577 Carbonic anhydrase 4 Homo sapiens 312 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211600&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134132755 375983017 CHEMBL3907577 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50554991 Nc1onc(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1ccccc1[N+]([O-])=O InChI=1S/C16H13N5O6S/c17-15-13(14(20-27-15)11-3-1-2-4-12(11)21(23)24)16(22)19-9-5-7-10(8-6-9)28(18,25)26/h1-8H,17H2,(H,19,22)(H2,18,25,26) TXYMBLPAHOHHLQ-UHFFFAOYSA-N 50211599 CHEMBL3986308 Carbonic anhydrase 4 Homo sapiens 246 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211599&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134156470 375983016 CHEMBL3986308 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555010 NS(=O)(=O)c1ccc(NC(=O)c2c(NC(=O)c3ccc(cc3)[N+]([O-])=O)onc2-c2ccc(Cl)cc2Cl)cc1 InChI=1S/C23H15Cl2N5O7S/c24-13-3-10-17(18(25)11-13)20-19(22(32)27-14-4-8-16(9-5-14)38(26,35)36)23(37-29-20)28-21(31)12-1-6-15(7-2-12)30(33)34/h1-11H,(H,27,32)(H,28,31)(H2,26,35,36) BEWQAXFWXRMAPB-UHFFFAOYSA-N 50211598 CHEMBL3953934 Carbonic anhydrase 4 Homo sapiens 428 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211598&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134144926 375983015 CHEMBL3953934 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555015 NS(=O)(=O)c1ccc(NC(=O)c2c(NC(=O)c3ccc(cc3)[N+]([O-])=O)onc2-c2ccc(F)cc2)cc1 InChI=1S/C23H16FN5O7S/c24-15-5-1-13(2-6-15)20-19(22(31)26-16-7-11-18(12-8-16)37(25,34)35)23(36-28-20)27-21(30)14-3-9-17(10-4-14)29(32)33/h1-12H,(H,26,31)(H,27,30)(H2,25,34,35) GGOKNRSYWRKUND-UHFFFAOYSA-N 50211643 CHEMBL3974625 Carbonic anhydrase 4 Homo sapiens 293 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211643&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134154346 375983021 CHEMBL3974625 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555029 NS(=O)(=O)c1ccc(NC(=O)c2c(NC(=O)c3ccccc3)onc2-c2ccc(Cl)cc2Cl)cc1 InChI=1S/C23H16Cl2N4O5S/c24-14-6-11-17(18(25)12-14)20-19(22(31)27-15-7-9-16(10-8-15)35(26,32)33)23(34-29-20)28-21(30)13-4-2-1-3-5-13/h1-12H,(H,27,31)(H,28,30)(H2,26,32,33) DZTHWFZMWOLVCQ-UHFFFAOYSA-N 50211508 CHEMBL3954963 Carbonic anhydrase 4 Homo sapiens 4429 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211508&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134144541 375982999 CHEMBL3954963 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555036 NS(=O)(=O)c1ccc(NC(=O)c2c(NC(=O)c3ccc(Cl)cc3)onc2-c2ccc(Cl)cc2Cl)cc1 InChI=1S/C23H15Cl3N4O5S/c24-13-3-1-12(2-4-13)21(31)29-23-19(20(30-35-23)17-10-5-14(25)11-18(17)26)22(32)28-15-6-8-16(9-7-15)36(27,33)34/h1-11H,(H,28,32)(H,29,31)(H2,27,33,34) DEHGMOVCXVWKNW-UHFFFAOYSA-N 50211510 CHEMBL3946274 Carbonic anhydrase 4 Homo sapiens 80 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211510&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134147911 375983001 CHEMBL3946274 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555042 COc1ccc(cc1)C(=O)Nc1onc(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1Cl InChI=1S/C24H18Cl2N4O6S/c1-35-16-7-2-13(3-8-16)22(31)29-24-20(21(30-36-24)18-11-4-14(25)12-19(18)26)23(32)28-15-5-9-17(10-6-15)37(27,33)34/h2-12H,1H3,(H,28,32)(H,29,31)(H2,27,33,34) ZIKSBMQYHZNLAC-UHFFFAOYSA-N 50211509 CHEMBL3979377 Carbonic anhydrase 4 Homo sapiens 288 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211509&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134152920 375983000 CHEMBL3979377 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555101 Nc1onc(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1 InChI=1S/C16H13ClN4O4S/c17-10-3-1-9(2-4-10)14-13(15(18)25-21-14)16(22)20-11-5-7-12(8-6-11)26(19,23)24/h1-8H,18H2,(H,20,22)(H2,19,23,24) ZYRYEGDPYHPNRA-UHFFFAOYSA-N 50211601 CHEMBL3889623 Carbonic anhydrase 4 Homo sapiens 47 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211601&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134130483 375983018 CHEMBL3889623 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555107 COc1cc(Cl)c(cc1OC)-c1noc(N)c1C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C18H17ClN4O6S/c1-27-13-7-11(12(19)8-14(13)28-2)16-15(17(20)29-23-16)18(24)22-9-3-5-10(6-4-9)30(21,25)26/h3-8H,20H2,1-2H3,(H,22,24)(H2,21,25,26) WCTZFYOPIMOTFD-UHFFFAOYSA-N 50211603 CHEMBL3916544 Carbonic anhydrase 4 Homo sapiens 47 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211603&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134142877 375983020 CHEMBL3916544 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555109 Nc1onc(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1c(Cl)cccc1Cl InChI=1S/C16H12Cl2N4O4S/c17-10-2-1-3-11(18)12(10)14-13(15(19)26-22-14)16(23)21-8-4-6-9(7-5-8)27(20,24)25/h1-7H,19H2,(H,21,23)(H2,20,24,25) VGNWINMWRQYNCC-UHFFFAOYSA-N 50211588 CHEMBL3894919 Carbonic anhydrase 4 Homo sapiens 146 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211588&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134137145 375983005 CHEMBL3894919 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555110 Nc1onc(-c2ccc(Cl)s2)c1C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C14H11ClN4O4S2/c15-10-6-5-9(24-10)12-11(13(16)23-19-12)14(20)18-7-1-3-8(4-2-7)25(17,21)22/h1-6H,16H2,(H,18,20)(H2,17,21,22) FEMMLRHJJPYAGV-UHFFFAOYSA-N 50211593 CHEMBL3925554 Carbonic anhydrase 4 Homo sapiens 266 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211593&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134141378 375983010 CHEMBL3925554 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555116 Nc1onc(-c2ccc(Cl)o2)c1C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C14H11ClN4O5S/c15-10-6-5-9(23-10)12-11(13(16)24-19-12)14(20)18-7-1-3-8(4-2-7)25(17,21)22/h1-6H,16H2,(H,18,20)(H2,17,21,22) REYNYHOURROZAR-UHFFFAOYSA-N 50211590 CHEMBL3897472 Carbonic anhydrase 4 Homo sapiens 407 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211590&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134133776 375983007 CHEMBL3897472 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555117 NS(=O)(=O)c1ccc(NC(=O)c2c(NC(=O)c3ccc(cc3)[N+]([O-])=O)onc2-c2ccccc2)cc1 InChI=1S/C23H17N5O7S/c24-36(33,34)18-12-8-16(9-13-18)25-22(30)19-20(14-4-2-1-3-5-14)27-35-23(19)26-21(29)15-6-10-17(11-7-15)28(31)32/h1-13H,(H,25,30)(H,26,29)(H2,24,33,34) OSURFULXBOMDNB-UHFFFAOYSA-N 50211597 CHEMBL3945204 Carbonic anhydrase 4 Homo sapiens 410 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211597&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134145685 375983014 CHEMBL3945204 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555118 NS(=O)(=O)c1ccc(NC(=O)c2c(NC(=O)c3ccc(Cl)cc3)onc2-c2c(Cl)cccc2Cl)cc1 InChI=1S/C23H15Cl3N4O5S/c24-13-6-4-12(5-7-13)21(31)29-23-19(20(30-35-23)18-16(25)2-1-3-17(18)26)22(32)28-14-8-10-15(11-9-14)36(27,33)34/h1-11H,(H,28,32)(H,29,31)(H2,27,33,34) DRXIKYMAOPQFGC-UHFFFAOYSA-N 50211594 CHEMBL3927339 Carbonic anhydrase 4 Homo sapiens 198 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211594&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134140829 375983011 CHEMBL3927339 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555119 COc1ccc(cc1)C(=O)Nc1onc(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1c(Cl)cccc1Cl InChI=1S/C24H18Cl2N4O6S/c1-35-15-9-5-13(6-10-15)22(31)29-24-20(21(30-36-24)19-17(25)3-2-4-18(19)26)23(32)28-14-7-11-16(12-8-14)37(27,33)34/h2-12H,1H3,(H,28,32)(H,29,31)(H2,27,33,34) SGCUEGUVJYPVCB-UHFFFAOYSA-N 50211602 CHEMBL3918052 Carbonic anhydrase 4 Homo sapiens 71 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211602&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134142323 375983019 CHEMBL3918052 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555131 Nc1onc(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1Cl InChI=1S/C16H12Cl2N4O4S/c17-8-1-6-11(12(18)7-8)14-13(15(19)26-22-14)16(23)21-9-2-4-10(5-3-9)27(20,24)25/h1-7H,19H2,(H,21,23)(H2,20,24,25) ZOSFXUWRABBACM-UHFFFAOYSA-N 50211644 CHEMBL3917491 Carbonic anhydrase 4 Homo sapiens 113 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211644&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134142989 375983022 CHEMBL3917491 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50555133 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2017.01.008 10.7270/Q2MS3VXQ 28111158 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Abant Izzet Baysal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548470 COc1ccc([C@H]2[C@@H](C(=O)N2c2ccc(cc2)S(N)(=O)=O)c2ccccc2)c(OC)c1 InChI=1S/C23H22N2O5S/c1-29-17-10-13-19(20(14-17)30-2)22-21(15-6-4-3-5-7-15)23(26)25(22)16-8-11-18(12-9-16)31(24,27)28/h3-14,21-22H,1-2H3,(H2,24,27,28)/t21-,22-/m0/s1 USTUXJJHLUYACA-VXKWHMMOSA-N 50209224 CHEMBL3885126 Carbonic anhydrase 4 Homo sapiens 51 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209224&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134130512 375982355 CHEMBL3885126 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548471 COc1cc(OC)c(cc1OC)[C@H]1[C@@H](C(=O)N1c1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C24H24N2O6S/c1-30-19-14-21(32-3)20(31-2)13-18(19)23-22(15-7-5-4-6-8-15)24(27)26(23)16-9-11-17(12-10-16)33(25,28)29/h4-14,22-23H,1-3H3,(H2,25,28,29)/t22-,23-/m0/s1 NHDULJUDNAJCLP-GOTSBHOMSA-N 50209282 CHEMBL3883491 Carbonic anhydrase 4 Homo sapiens 0.950000 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209282&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134131086 375982358 CHEMBL3883491 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548472 COc1ccc(cc1)[C@H]1[C@@H](N(C1=O)c1ccc(cc1)S(N)(=O)=O)c1ccc(OC)c(OC)c1 InChI=1S/C24H24N2O6S/c1-30-18-9-4-15(5-10-18)22-23(16-6-13-20(31-2)21(14-16)32-3)26(24(22)27)17-7-11-19(12-8-17)33(25,28)29/h4-14,22-23H,1-3H3,(H2,25,28,29)/t22-,23-/m0/s1 IJIDZGOCIMGBNL-GOTSBHOMSA-N 50209283 CHEMBL3885230 Carbonic anhydrase 4 Homo sapiens 0.530000 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209283&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134131189 375982359 CHEMBL3885230 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548724 COc1ccc(cc1OC)[C@H]1[C@@H](C(=O)N1c1ccc(cc1)S(N)(=O)=O)c1cccs1 InChI=1S/C21H20N2O5S2/c1-27-16-10-5-13(12-17(16)28-2)20-19(18-4-3-11-29-18)21(24)23(20)14-6-8-15(9-7-14)30(22,25)26/h3-12,19-20H,1-2H3,(H2,22,25,26)/t19-,20-/m0/s1 HNNKXKOZMNUTRV-PMACEKPBSA-N 50209287 CHEMBL3884217 Carbonic anhydrase 4 Homo sapiens 7.4 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209287&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134130029 375982363 CHEMBL3884217 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548810 COc1cc(cc(OC)c1OC)[C@H]1[C@@H](C(=O)N1c1ccc(cc1)S(N)(=O)=O)c1cccs1 InChI=1S/C22H22N2O6S2/c1-28-16-11-13(12-17(29-2)21(16)30-3)20-19(18-5-4-10-31-18)22(25)24(20)14-6-8-15(9-7-14)32(23,26)27/h4-12,19-20H,1-3H3,(H2,23,26,27)/t19-,20-/m0/s1 NVTFNOJXPJWMLH-PMACEKPBSA-N 50209285 CHEMBL3884696 Carbonic anhydrase 4 Homo sapiens 3.7 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209285&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134131574 375982361 CHEMBL3884696 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548811 NS(=O)(=O)c1ccc(cc1)N1[C@H]([C@@H](C1=O)c1ccccc1)c1ccccc1OC(F)F InChI=1S/C22H18F2N2O4S/c23-22(24)30-18-9-5-4-8-17(18)20-19(14-6-2-1-3-7-14)21(27)26(20)15-10-12-16(13-11-15)31(25,28)29/h1-13,19-20,22H,(H2,25,28,29)/t19-,20-/m0/s1 KFXGWBBGGVAWMD-PMACEKPBSA-N 50209289 CHEMBL3885091 Carbonic anhydrase 4 Homo sapiens 44 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209289&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 132495328 375982365 CHEMBL3885091 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548827 COc1cc(OC)c([C@H]2[C@@H](C(=O)N2c2ccc(cc2)S(N)(=O)=O)c2ccccc2)c(OC)c1 InChI=1S/C24H24N2O6S/c1-30-17-13-19(31-2)22(20(14-17)32-3)23-21(15-7-5-4-6-8-15)24(27)26(23)16-9-11-18(12-10-16)33(25,28)29/h4-14,21,23H,1-3H3,(H2,25,28,29)/t21-,23+/m0/s1 QUKOYTZXZFZYPT-JTHBVZDNSA-N 50209290 CHEMBL3883755 Carbonic anhydrase 4 Homo sapiens 1.8 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209290&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134130177 375982366 CHEMBL3883755 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548839 COc1ccc(cc1OC)[C@H]1[C@@H](C(=O)N1c1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C23H22N2O5S/c1-29-19-13-8-16(14-20(19)30-2)22-21(15-6-4-3-5-7-15)23(26)25(22)17-9-11-18(12-10-17)31(24,27)28/h3-14,21-22H,1-2H3,(H2,24,27,28)/t21-,22-/m0/s1 VFHKIABQXHFFPR-VXKWHMMOSA-N 50209293 CHEMBL3884597 Carbonic anhydrase 4 Homo sapiens 35 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209293&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134131567 375982368 CHEMBL3884597 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548853 COc1cc(cc(OC)c1OC)[C@H]1[C@@H](C(=O)N1c1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C24H24N2O6S/c1-30-19-13-16(14-20(31-2)23(19)32-3)22-21(15-7-5-4-6-8-15)24(27)26(22)17-9-11-18(12-10-17)33(25,28)29/h4-14,21-22H,1-3H3,(H2,25,28,29)/t21-,22-/m0/s1 XHNZYDLNBBLDGC-VXKWHMMOSA-N 50209288 CHEMBL3885451 Carbonic anhydrase 4 Homo sapiens 0.640000 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209288&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134130471 375982364 CHEMBL3885451 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548855 COc1ccc(OC)c(c1)[C@H]1[C@@H](C(=O)N1c1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C23H22N2O5S/c1-29-17-10-13-20(30-2)19(14-17)22-21(15-6-4-3-5-7-15)23(26)25(22)16-8-11-18(12-9-16)31(24,27)28/h3-14,21-22H,1-2H3,(H2,24,27,28)/t21-,22-/m0/s1 GJEOIPWOOVXMSD-VXKWHMMOSA-N 50209292 CHEMBL3884793 Carbonic anhydrase 4 Homo sapiens 36 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209292&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134131361 375982367 CHEMBL3884793 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548860 COc1cc(OC)c([C@H]2[C@@H](C(=O)N2c2ccc(cc2)S(N)(=O)=O)c2cccs2)c(OC)c1 InChI=1S/C22H22N2O6S2/c1-28-14-11-16(29-2)19(17(12-14)30-3)21-20(18-5-4-10-31-18)22(25)24(21)13-6-8-15(9-7-13)32(23,26)27/h4-12,20-21H,1-3H3,(H2,23,26,27)/t20-,21-/m0/s1 PINVBIOHURQBSS-SFTDATJTSA-N 50209225 CHEMBL3883807 Carbonic anhydrase 4 Homo sapiens 0.650000 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209225&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134130364 375982356 CHEMBL3883807 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548861 COc1cc(OC)c(cc1OC)[C@H]1[C@@H](C(=O)N1c1ccc(cc1)S(N)(=O)=O)c1cccs1 InChI=1S/C22H22N2O6S2/c1-28-16-12-18(30-3)17(29-2)11-15(16)21-20(19-5-4-10-31-19)22(25)24(21)13-6-8-14(9-7-13)32(23,26)27/h4-12,20-21H,1-3H3,(H2,23,26,27)/t20-,21-/m0/s1 GHNOBPHHWDUEPX-SFTDATJTSA-N 50209284 CHEMBL3884126 Carbonic anhydrase 4 Homo sapiens 5 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209284&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134131535 375982360 CHEMBL3884126 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548883 COc1ccc(OC)c(c1)[C@H]1[C@@H](C(=O)N1c1ccc(cc1)S(N)(=O)=O)c1cccs1 InChI=1S/C21H20N2O5S2/c1-27-14-7-10-17(28-2)16(12-14)20-19(18-4-3-11-29-18)21(24)23(20)13-5-8-15(9-6-13)30(22,25)26/h3-12,19-20H,1-2H3,(H2,22,25,26)/t19-,20-/m0/s1 QKYLBJRXQYJQCW-PMACEKPBSA-N 50209286 CHEMBL3884261 Carbonic anhydrase 4 Homo sapiens 43 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209286&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134130566 375982362 CHEMBL3884261 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548884 COc1ccc([C@H]2[C@@H](C(=O)N2c2ccc(cc2)S(N)(=O)=O)c2ccccc2)c(OC)c1OC InChI=1S/C24H24N2O6S/c1-30-19-14-13-18(22(31-2)23(19)32-3)21-20(15-7-5-4-6-8-15)24(27)26(21)16-9-11-17(12-10-16)33(25,28)29/h4-14,20-21H,1-3H3,(H2,25,28,29)/t20-,21-/m0/s1 HHWYFTNQJISJLG-SFTDATJTSA-N 50209226 CHEMBL3884755 Carbonic anhydrase 4 Homo sapiens 35 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50209226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50209226&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 134129901 375982357 CHEMBL3884755 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50548913 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2016.11.027 10.7270/Q2G73GQQ 27919611 Angapelly, S; Ramya, PV; Angeli, A; Monti, SM; Buonanno, M; Alvala, M; Supuran, CT; Arifuddin, M National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680049 Cc1ccc2NC(=O)\C(=N/CCc3ccc(cc3)S(N)(=O)=O)c2c1 InChI=1S/C17H17N3O3S/c1-11-2-7-15-14(10-11)16(17(21)20-15)19-9-8-12-3-5-13(6-4-12)24(18,22)23/h2-7,10H,8-9H2,1H3,(H2,18,22,23)(H,19,20,21) ITABQQJKHWJXOZ-UHFFFAOYSA-N 50230939 CHEMBL4067135 Carbonic anhydrase 4 Homo sapiens 4 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230939&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137633409 383543158 CHEMBL4067135 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680053 NS(=O)(=O)c1ccc(CC\N=C2/NC(=O)\C(S2)=C2\C(=O)Nc3ccc(Br)cc23)cc1 InChI=1S/C19H15BrN4O4S2/c20-11-3-6-14-13(9-11)15(17(25)23-14)16-18(26)24-19(29-16)22-8-7-10-1-4-12(5-2-10)30(21,27)28/h1-6,9H,7-8H2,(H,23,25)(H2,21,27,28)(H,22,24,26)/b16-15- WYTBMDUZQWLZPT-NXVVXOECSA-N 50230945 CHEMBL4060777 Carbonic anhydrase 4 Homo sapiens 41 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230945&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137637736 383543164 CHEMBL4060777 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680060 NS(=O)(=O)c1ccc(CC\N=C2/C(=O)Nc3ccccc23)cc1 InChI=1S/C16H15N3O3S/c17-23(21,22)12-7-5-11(6-8-12)9-10-18-15-13-3-1-2-4-14(13)19-16(15)20/h1-8H,9-10H2,(H2,17,21,22)(H,18,19,20) SKZLQDFIQFTGPQ-UHFFFAOYSA-N 50230931 CHEMBL4066127 Carbonic anhydrase 4 Homo sapiens 272 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230931&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 136728963 383543151 CHEMBL4066127 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680092 NS(=O)(=O)c1ccc(CC\N=C2/NC(=O)\C(S2)=C2\C(=O)Nc3ccc(F)cc23)cc1 InChI=1S/C19H15FN4O4S2/c20-11-3-6-14-13(9-11)15(17(25)23-14)16-18(26)24-19(29-16)22-8-7-10-1-4-12(5-2-10)30(21,27)28/h1-6,9H,7-8H2,(H,23,25)(H2,21,27,28)(H,22,24,26)/b16-15- HGWYOHVFBAVTAT-NXVVXOECSA-N 50230935 CHEMBL4099138 Carbonic anhydrase 4 Homo sapiens 270 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230935&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137661167 383543155 CHEMBL4099138 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680121 NS(=O)(=O)c1ccc(CC\N=C2/C(=O)N(Cc3ccccc3)c3ccccc23)cc1 InChI=1S/C23H21N3O3S/c24-30(28,29)19-12-10-17(11-13-19)14-15-25-22-20-8-4-5-9-21(20)26(23(22)27)16-18-6-2-1-3-7-18/h1-13H,14-16H2,(H2,24,28,29)/b25-22- FZFSMBKULNQDSU-LVWGJNHUSA-N 50230938 CHEMBL4069467 Carbonic anhydrase 4 Homo sapiens 2070 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230938&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137632178 383543157 CHEMBL4069467 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680165 NS(=O)(=O)c1ccc(CC\N=C2/C(=O)Nc3ccc(Cl)cc23)cc1 InChI=1S/C16H14ClN3O3S/c17-11-3-6-14-13(9-11)15(16(21)20-14)19-8-7-10-1-4-12(5-2-10)24(18,22)23/h1-6,9H,7-8H2,(H2,18,22,23)(H,19,20,21) KULAYSBOYLCMAI-UHFFFAOYSA-N 50230948 CHEMBL4077244 Carbonic anhydrase 4 Homo sapiens 46 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230948&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137649321 383543167 CHEMBL4077244 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680180 NS(=O)(=O)c1ccc(CC\N=C2/C(=O)Nc3ccc(Br)cc23)cc1 InChI=1S/C16H14BrN3O3S/c17-11-3-6-14-13(9-11)15(16(21)20-14)19-8-7-10-1-4-12(5-2-10)24(18,22)23/h1-6,9H,7-8H2,(H2,18,22,23)(H,19,20,21) GKOGIEQVZKHPPF-UHFFFAOYSA-N 50230944 CHEMBL4088398 Carbonic anhydrase 4 Homo sapiens 37 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230944&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 135530880 383543163 CHEMBL4088398 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680218 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680221 CN1C(=O)\C(=N/CCc2ccc(cc2)S(N)(=O)=O)c2cc(Cl)ccc12 InChI=1S/C17H16ClN3O3S/c1-21-15-7-4-12(18)10-14(15)16(17(21)22)20-9-8-11-2-5-13(6-3-11)25(19,23)24/h2-7,10H,8-9H2,1H3,(H2,19,23,24)/b20-16- HIAWQXGXORBVKB-SILNSSARSA-N 50230937 CHEMBL4095939 Carbonic anhydrase 4 Homo sapiens 31 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230937&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137654343 383543156 CHEMBL4095939 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680232 NS(=O)(=O)c1ccc(CC\N=C2/NC(=O)\C(S2)=C2\C(=O)Nc3ccc(cc23)[N+]([O-])=O)cc1 InChI=1S/C19H15N5O6S2/c20-32(29,30)12-4-1-10(2-5-12)7-8-21-19-23-18(26)16(31-19)15-13-9-11(24(27)28)3-6-14(13)22-17(15)25/h1-6,9H,7-8H2,(H,22,25)(H2,20,29,30)(H,21,23,26)/b16-15- JIEXAWZNKMHLBP-NXVVXOECSA-N 50230932 CHEMBL4103521 Carbonic anhydrase 4 Homo sapiens 37 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230932&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137656447 383543152 CHEMBL4103521 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680242 NCCc1ccc(cc1)S(N)(=O)=O InChI=1S/C8H12N2O2S/c9-6-5-7-1-3-8(4-2-7)13(10,11)12/h1-4H,5-6,9H2,(H2,10,11,12) FXNSVEQMUYPYJS-UHFFFAOYSA-N 10861 4-(2-aminoethyl)benzene-1-sulfonamide::CHEMBL7087::aromatic sulfonamide compound 7::aromatic/heteroaromatic sulfonamide 6 Carbonic anhydrase 4 Homo sapiens 349 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10861&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ZYX 2NNG 169682 46511433 CHEMBL7087 DB08782 ZINC00056629 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680243 Cc1cc2\C(=N\CCc3ccc(cc3)S(N)(=O)=O)C(=O)Nc2c(C)c1 InChI=1S/C18H19N3O3S/c1-11-9-12(2)16-15(10-11)17(18(22)21-16)20-8-7-13-3-5-14(6-4-13)25(19,23)24/h3-6,9-10H,7-8H2,1-2H3,(H2,19,23,24)(H,20,21,22) BDMKXSRCHXJZER-UHFFFAOYSA-N 50230947 CHEMBL4078069 Carbonic anhydrase 4 Homo sapiens 27 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230947&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137651491 383543166 CHEMBL4078069 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680249 NS(=O)(=O)c1ccc(CC\N=C2/NC(=O)\C(S2)=C2\C(=O)Nc3ccccc23)cc1 InChI=1S/C19H16N4O4S2/c20-29(26,27)12-7-5-11(6-8-12)9-10-21-19-23-18(25)16(28-19)15-13-3-1-2-4-14(13)22-17(15)24/h1-8H,9-10H2,(H,22,24)(H2,20,26,27)(H,21,23,25)/b16-15- JCMFNSIKKLYXCX-NXVVXOECSA-N 50230946 CHEMBL4081098 Carbonic anhydrase 4 Homo sapiens 329 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230946&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137645734 383543165 CHEMBL4081098 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680252 NS(=O)(=O)c1ccc(CC\N=C2/C(=O)N(Cc3ccccc3)c3ccc(Br)cc23)cc1 InChI=1S/C23H20BrN3O3S/c24-18-8-11-21-20(14-18)22(23(28)27(21)15-17-4-2-1-3-5-17)26-13-12-16-6-9-19(10-7-16)31(25,29)30/h1-11,14H,12-13,15H2,(H2,25,29,30)/b26-22- SOAJDCMWLJVSBL-ROMGYVFFSA-N 50230943 CHEMBL4080175 Carbonic anhydrase 4 Homo sapiens 1434 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230943&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137648279 383543162 CHEMBL4080175 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680260 CN1C(=O)\C(=N/CCc2ccc(cc2)S(N)(=O)=O)c2cc(Br)ccc12 InChI=1S/C17H16BrN3O3S/c1-21-15-7-4-12(18)10-14(15)16(17(21)22)20-9-8-11-2-5-13(6-3-11)25(19,23)24/h2-7,10H,8-9H2,1H3,(H2,19,23,24)/b20-16- XVGBJCXVGIIRJO-SILNSSARSA-N 50230950 CHEMBL4096684 Carbonic anhydrase 4 Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230950&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137655984 383543169 CHEMBL4096684 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680261 COc1ccc2NC(=O)\C(=N/CCc3ccc(cc3)S(N)(=O)=O)c2c1 InChI=1S/C17H17N3O4S/c1-24-12-4-7-15-14(10-12)16(17(21)20-15)19-9-8-11-2-5-13(6-3-11)25(18,22)23/h2-7,10H,8-9H2,1H3,(H2,18,22,23)(H,19,20,21) DRNCSPJAWMPTLB-UHFFFAOYSA-N 50230949 CHEMBL4096121 Carbonic anhydrase 4 Homo sapiens 43 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230949&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137655261 383543168 CHEMBL4096121 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680296 CN1C(=O)\C(=N/CCc2ccc(cc2)S(N)(=O)=O)c2ccccc12 InChI=1S/C17H17N3O3S/c1-20-15-5-3-2-4-14(15)16(17(20)21)19-11-10-12-6-8-13(9-7-12)24(18,22)23/h2-9H,10-11H2,1H3,(H2,18,22,23)/b19-16- SYZDUUPRTIXLRT-MNDPQUGUSA-N 50230940 CHEMBL4069845 Carbonic anhydrase 4 Homo sapiens 16 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230940&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137638456 383543159 CHEMBL4069845 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680320 NS(=O)(=O)c1ccc(CC\N=C2/NC(=O)\C(S2)=C2\C(=O)Nc3ccc(Cl)cc23)cc1 InChI=1S/C19H15ClN4O4S2/c20-11-3-6-14-13(9-11)15(17(25)23-14)16-18(26)24-19(29-16)22-8-7-10-1-4-12(5-2-10)30(21,27)28/h1-6,9H,7-8H2,(H,23,25)(H2,21,27,28)(H,22,24,26)/b16-15- WIRNIVVIEUHIFY-NXVVXOECSA-N 50230934 CHEMBL4088987 Carbonic anhydrase 4 Homo sapiens 45 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230934&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137644914 383543154 CHEMBL4088987 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680335 Cc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\CCc3ccc(cc3)S(N)(=O)=O)c2c1 InChI=1S/C20H18N4O4S2/c1-11-2-7-15-14(10-11)16(18(25)23-15)17-19(26)24-20(29-17)22-9-8-12-3-5-13(6-4-12)30(21,27)28/h2-7,10H,8-9H2,1H3,(H,23,25)(H2,21,27,28)(H,22,24,26)/b17-16- UQXPJHRLYMALJP-MSUUIHNZSA-N 50230933 CHEMBL4085590 Carbonic anhydrase 4 Homo sapiens 36 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230933&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137648717 383543153 CHEMBL4085590 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680336 NS(=O)(=O)c1ccc(CC\N=C2/NC(=O)CS2)cc1 InChI=1S/C11H13N3O3S2/c12-19(16,17)9-3-1-8(2-4-9)5-6-13-11-14-10(15)7-18-11/h1-4H,5-7H2,(H2,12,16,17)(H,13,14,15) JDFAVXKRIKTDMF-UHFFFAOYSA-N 50230942 CHEMBL4085952 Carbonic anhydrase 4 Homo sapiens 79 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230942&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137644307 383543161 CHEMBL4085952 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50680385 NS(=O)(=O)c1ccc(CC\N=C2/C(=O)N(Cc3ccccc3)c3ccc(Cl)cc23)cc1 InChI=1S/C23H20ClN3O3S/c24-18-8-11-21-20(14-18)22(23(28)27(21)15-17-4-2-1-3-5-17)26-13-12-16-6-9-19(10-7-16)31(25,29)30/h1-11,14H,12-13,15H2,(H2,25,29,30)/b26-22- MWBNPBNXIXNYRM-ROMGYVFFSA-N 50230941 CHEMBL4104409 Carbonic anhydrase 4 Homo sapiens 1800 ChEMBL 10.1016/j.ejmech.2017.01.017 10.7270/Q2862JPH 28109946 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230941&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137656796 383543160 CHEMBL4104409 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681546 CC(=O)Nc1cc(no1)-c1ccc(C)c(c1)S(N)(=O)=O InChI=1S/C12H13N3O4S/c1-7-3-4-9(5-11(7)20(13,17)18)10-6-12(19-15-10)14-8(2)16/h3-6H,1-2H3,(H,14,16)(H2,13,17,18) AWVYVIXIVZZHJY-UHFFFAOYSA-N 50231543 CHEMBL4097705 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231543&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137662256 384226197 CHEMBL4097705 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681547 COc1ccc(cc1S(N)(=O)=O)-c1cc(NC(C)=O)on1 InChI=1S/C12H13N3O5S/c1-7(16)14-12-6-9(15-20-12)8-3-4-10(19-2)11(5-8)21(13,17)18/h3-6H,1-2H3,(H,14,16)(H2,13,17,18) ZWHWUUOKHNAUBY-UHFFFAOYSA-N 50231515 CHEMBL4087551 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231515&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137642047 384226184 CHEMBL4087551 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681548 COc1ccc(c(c1)-c1cc(NC(C)=O)on1)S(N)(=O)=O InChI=1S/C12H13N3O5S/c1-7(16)14-12-6-10(15-20-12)9-5-8(19-2)3-4-11(9)21(13,17)18/h3-6H,1-2H3,(H,14,16)(H2,13,17,18) ZNCSPDKMCZPEEJ-UHFFFAOYSA-N 50231516 CHEMBL4104116 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231516&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137658275 384226185 CHEMBL4104116 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681550 CC(=O)Nc1cc(no1)-c1cc(c(C)s1)S(N)(=O)=O InChI=1S/C10H11N3O4S2/c1-5-9(19(11,15)16)4-8(18-5)7-3-10(17-13-7)12-6(2)14/h3-4H,1-2H3,(H,12,14)(H2,11,15,16) RJYIYDGTQURBHU-UHFFFAOYSA-N 50231530 CHEMBL4090546 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231530&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137641717 384226186 CHEMBL4090546 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681557 CC(=O)Nc1cc(no1)-c1csc(c1)S(N)(=O)=O InChI=1S/C9H9N3O4S2/c1-5(13)11-8-3-7(12-16-8)6-2-9(17-4-6)18(10,14)15/h2-4H,1H3,(H,11,13)(H2,10,14,15) OAXXTLQPXFSIMN-UHFFFAOYSA-N 50231531 CHEMBL4071226 Carbonic anhydrase 4 Homo sapiens 94 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231531&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 132961363 384226187 CHEMBL4071226 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681558 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681560 Cc1ccc(cc1S(N)(=O)=O)-c1noc(N)c1S(N)(=O)=O InChI=1S/C10H12N4O5S2/c1-5-2-3-6(4-7(5)20(12,15)16)8-9(21(13,17)18)10(11)19-14-8/h2-4H,11H2,1H3,(H2,12,15,16)(H2,13,17,18) RSIDZAKDVUGKLQ-UHFFFAOYSA-N 50231532 CHEMBL4072247 Carbonic anhydrase 4 Homo sapiens 8.9 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231532&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 132961364 384226188 CHEMBL4072247 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681561 COc1ccc(cc1S(N)(=O)=O)-c1noc(N)c1S(N)(=O)=O InChI=1S/C10H12N4O6S2/c1-19-6-3-2-5(4-7(6)21(12,15)16)8-9(22(13,17)18)10(11)20-14-8/h2-4H,11H2,1H3,(H2,12,15,16)(H2,13,17,18) XOVLRGKZVFYCME-UHFFFAOYSA-N 50231533 CHEMBL4100722 Carbonic anhydrase 4 Homo sapiens 9.3 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231533&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137660288 384226189 CHEMBL4100722 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681562 Nc1onc(-c2ccc(s2)S(N)(=O)=O)c1S(N)(=O)=O InChI=1S/C7H8N4O5S3/c8-7-6(19(10,14)15)5(11-16-7)3-1-2-4(17-3)18(9,12)13/h1-2H,8H2,(H2,9,12,13)(H2,10,14,15) OUYNGFGNMQVUMV-UHFFFAOYSA-N 50231534 CHEMBL4075010 Carbonic anhydrase 4 Homo sapiens 531 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231534&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137649001 384226190 CHEMBL4075010 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681563 Cc1sc(cc1S(N)(=O)=O)-c1noc(N)c1S(N)(=O)=O InChI=1S/C8H10N4O5S3/c1-3-5(19(10,13)14)2-4(18-3)6-7(20(11,15)16)8(9)17-12-6/h2H,9H2,1H3,(H2,10,13,14)(H2,11,15,16) AATRVZNCPJUBRA-UHFFFAOYSA-N 50231535 CHEMBL4101695 Carbonic anhydrase 4 Homo sapiens 533 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231535&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137661027 384226191 CHEMBL4101695 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681564 Nc1onc(-c2csc(c2)S(N)(=O)=O)c1S(N)(=O)=O InChI=1S/C7H8N4O5S3/c8-7-6(19(10,14)15)5(11-16-7)3-1-4(17-2-3)18(9,12)13/h1-2H,8H2,(H2,9,12,13)(H2,10,14,15) GHNLDUJMNKEUDC-UHFFFAOYSA-N 50231536 CHEMBL4064451 Carbonic anhydrase 4 Homo sapiens 185 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231536&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137637173 384226192 CHEMBL4064451 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681565 CC(=O)Nc1onc(C)c1-c1ccc(C)c(c1)S(N)(=O)=O InChI=1S/C13H15N3O4S/c1-7-4-5-10(6-11(7)21(14,18)19)12-8(2)16-20-13(12)15-9(3)17/h4-6H,1-3H3,(H,15,17)(H2,14,18,19) VFVPVDQFWVJTRP-UHFFFAOYSA-N 50231538 CHEMBL4102368 Carbonic anhydrase 4 Homo sapiens 7.5 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231538&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137662201 384226193 CHEMBL4102368 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681566 COc1ccc(cc1S(N)(=O)=O)-c1c(C)noc1NC(C)=O InChI=1S/C13H15N3O5S/c1-7-12(13(21-16-7)15-8(2)17)9-4-5-10(20-3)11(6-9)22(14,18)19/h4-6H,1-3H3,(H,15,17)(H2,14,18,19) KCBDKKDZHHOWIY-UHFFFAOYSA-N 50231539 CHEMBL4078092 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231539&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137652373 384226194 CHEMBL4078092 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681567 CC(=O)Nc1onc(C)c1-c1ccc(c(C)c1)S(N)(=O)=O InChI=1S/C13H15N3O4S/c1-7-6-10(4-5-11(7)21(14,18)19)12-8(2)16-20-13(12)15-9(3)17/h4-6H,1-3H3,(H,15,17)(H2,14,18,19) FLJOQROGTATJAB-UHFFFAOYSA-N 50231540 CHEMBL4083461 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231540&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137648644 384226195 CHEMBL4083461 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681622 CC(=O)Nc1cc(no1)-c1ccc(s1)S(N)(=O)=O InChI=1S/C9H9N3O4S2/c1-5(13)11-8-4-6(12-16-8)7-2-3-9(17-7)18(10,14)15/h2-4H,1H3,(H,11,13)(H2,10,14,15) VQJKHMYSNWIOBP-UHFFFAOYSA-N 50231544 CHEMBL4062578 Carbonic anhydrase 4 Homo sapiens 6148 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231544&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137635051 384226198 CHEMBL4062578 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681623 Nc1onc(c1S(N)(=O)=O)-c1cccc(c1)S(N)(=O)=O InChI=1S/C9H10N4O5S2/c10-9-8(20(12,16)17)7(13-18-9)5-2-1-3-6(4-5)19(11,14)15/h1-4H,10H2,(H2,11,14,15)(H2,12,16,17) WELDKCZSQSGFDO-UHFFFAOYSA-N 50231545 CHEMBL4093011 Carbonic anhydrase 4 Homo sapiens 1752 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231545&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137656061 384226199 CHEMBL4093011 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681624 COc1ccc(c(c1)-c1noc(N)c1S(N)(=O)=O)S(N)(=O)=O InChI=1S/C10H12N4O6S2/c1-19-5-2-3-7(21(12,15)16)6(4-5)8-9(22(13,17)18)10(11)20-14-8/h2-4H,11H2,1H3,(H2,12,15,16)(H2,13,17,18) LVLZEDSHLYHHOY-UHFFFAOYSA-N 50231547 CHEMBL4082731 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231547&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137646956 384226200 CHEMBL4082731 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681630 CC(=O)Nc1onc(C)c1-c1ccc(cc1)S(N)(=O)=O InChI=1S/C12H13N3O4S/c1-7-11(12(19-15-7)14-8(2)16)9-3-5-10(6-4-9)20(13,17)18/h3-6H,1-2H3,(H,14,16)(H2,13,17,18) LPLPEJCRMCTILK-UHFFFAOYSA-N 50231548 CHEMBL4085984 Carbonic anhydrase 4 Homo sapiens 207 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231548&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 132961365 384226201 CHEMBL4085984 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50681631 COc1ccc(c(c1)-c1c(C)noc1NC(C)=O)S(N)(=O)=O InChI=1S/C13H15N3O5S/c1-7-12(13(21-16-7)15-8(2)17)10-6-9(20-3)4-5-11(10)22(14,18)19/h4-6H,1-3H3,(H,15,17)(H2,14,18,19) LOOHHYCFXUTNBN-UHFFFAOYSA-N 50231542 CHEMBL4101452 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2017.02.018 10.7270/Q2ZP48CZ 28237553 Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231542&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137659383 384226196 CHEMBL4101452 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678192 C[S+]([O-])c1ccc(\C=C2\C(C)=C(CC(=O)NCCOc3ccc4oc(=O)ccc4c3)c3cc(F)ccc23)cc1 InChI=1S/C31H26FNO5S/c1-19-26(15-20-3-8-24(9-4-20)39(2)36)25-10-6-22(32)17-28(25)27(19)18-30(34)33-13-14-37-23-7-11-29-21(16-23)5-12-31(35)38-29/h3-12,15-17H,13-14,18H2,1-2H3,(H,33,34)/b26-15- XOKLEXHVYHSJAW-YSMPRRRNSA-N 50230193 CHEMBL4097542 Carbonic anhydrase 4 Homo sapiens 7.5 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230193&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137659205 383542978 CHEMBL4097542 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678193 CC(C(=O)NCCOc1ccc2oc(=O)ccc2c1)c1cccc(c1)C(=O)c1ccccc1 InChI=1S/C27H23NO5/c1-18(20-8-5-9-22(16-20)26(30)19-6-3-2-4-7-19)27(31)28-14-15-32-23-11-12-24-21(17-23)10-13-25(29)33-24/h2-13,16-18H,14-15H2,1H3,(H,28,31) DVWBHLMOMYEMGE-UHFFFAOYSA-N 50230194 CHEMBL4082922 Carbonic anhydrase 4 Homo sapiens 4.4 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230194&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137647221 383542979 CHEMBL4082922 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678195 CC(C)Cc1ccc(cc1)C(C)C(=O)NCCOc1ccc2oc(=O)ccc2c1 InChI=1S/C24H27NO4/c1-16(2)14-18-4-6-19(7-5-18)17(3)24(27)25-12-13-28-21-9-10-22-20(15-21)8-11-23(26)29-22/h4-11,15-17H,12-14H2,1-3H3,(H,25,27) STRMNDIHFLXQEH-UHFFFAOYSA-N 50230195 CHEMBL4100903 Carbonic anhydrase 4 Homo sapiens 0.440000 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230195&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137658877 383542980 CHEMBL4100903 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678204 CC(C(=O)NCCOc1ccc2oc(=O)ccc2c1)c1ccc(c(F)c1)-c1ccccc1 InChI=1S/C26H22FNO4/c1-17(19-7-10-22(23(27)16-19)18-5-3-2-4-6-18)26(30)28-13-14-31-21-9-11-24-20(15-21)8-12-25(29)32-24/h2-12,15-17H,13-14H2,1H3,(H,28,30) RDCNYQNKGWIHTR-UHFFFAOYSA-N 50230196 CHEMBL4096350 Carbonic anhydrase 4 Homo sapiens 0.810000 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230196&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137655528 383542981 CHEMBL4096350 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678215 O=C(NCCOc1ccc2oc(=O)ccc2c1)C1CCn2c1ccc2C(=O)c1ccccc1 InChI=1S/C26H22N2O5/c29-24-11-6-18-16-19(7-10-23(18)33-24)32-15-13-27-26(31)20-12-14-28-21(20)8-9-22(28)25(30)17-4-2-1-3-5-17/h1-11,16,20H,12-15H2,(H,27,31) HREFIMOFGJMXJB-UHFFFAOYSA-N 50230197 CHEMBL4060402 Carbonic anhydrase 4 Homo sapiens 0.790000 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230197&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137636350 383542982 CHEMBL4060402 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678241 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)NCCOc3ccc4ccc(=O)oc4c3)c2c1 InChI=1S/C30H25ClN2O6/c1-18-24(17-28(34)32-13-14-38-23-9-5-19-6-12-29(35)39-27(19)16-23)25-15-22(37-2)10-11-26(25)33(18)30(36)20-3-7-21(31)8-4-20/h3-12,15-16H,13-14,17H2,1-2H3,(H,32,34) FLECULXDKQQRRJ-UHFFFAOYSA-N 50230198 CHEMBL4087725 Carbonic anhydrase 4 Homo sapiens 8.3 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230198&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137642054 383542983 CHEMBL4087725 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678256 C[S+]([O-])c1ccc(\C=C2\C(C)=C(CC(=O)NCCOc3ccc4ccc(=O)oc4c3)c3cc(F)ccc23)cc1 InChI=1S/C31H26FNO5S/c1-19-26(15-20-3-9-24(10-4-20)39(2)36)25-11-7-22(32)16-28(25)27(19)18-30(34)33-13-14-37-23-8-5-21-6-12-31(35)38-29(21)17-23/h3-12,15-17H,13-14,18H2,1-2H3,(H,33,34)/b26-15- NMYIRICXYKYTCN-YSMPRRRNSA-N 50230199 CHEMBL4076291 Carbonic anhydrase 4 Homo sapiens 9.0 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230199&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137652305 383542984 CHEMBL4076291 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678260 CC(C(=O)NCCOc1ccc2ccc(=O)oc2c1)c1cccc(c1)C(=O)c1ccccc1 InChI=1S/C27H23NO5/c1-18(21-8-5-9-22(16-21)26(30)20-6-3-2-4-7-20)27(31)28-14-15-32-23-12-10-19-11-13-25(29)33-24(19)17-23/h2-13,16-18H,14-15H2,1H3,(H,28,31) SWCBFPGZAGDZNP-UHFFFAOYSA-N 50230200 CHEMBL4079848 Carbonic anhydrase 4 Homo sapiens 9.5 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230200&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137652226 383542985 CHEMBL4079848 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678268 Clc1cccc(Cl)c1Nc1ccccc1CC(=O)NCCOc1ccc2ccc(=O)oc2c1 InChI=1S/C25H20Cl2N2O4/c26-19-5-3-6-20(27)25(19)29-21-7-2-1-4-17(21)14-23(30)28-12-13-32-18-10-8-16-9-11-24(31)33-22(16)15-18/h1-11,15,29H,12-14H2,(H,28,30) MAYQUXWUTAAHEK-UHFFFAOYSA-N 50230201 CHEMBL4103176 Carbonic anhydrase 4 Homo sapiens 9.1 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230201&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137658375 383542986 CHEMBL4103176 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678271 CC(C(=O)NCCOc1ccc2ccc(=O)oc2c1)c1ccc(c(F)c1)-c1ccccc1 InChI=1S/C26H22FNO4/c1-17(20-8-11-22(23(27)15-20)18-5-3-2-4-6-18)26(30)28-13-14-31-21-10-7-19-9-12-25(29)32-24(19)16-21/h2-12,15-17H,13-14H2,1H3,(H,28,30) HZDQGBWBFORQGL-UHFFFAOYSA-N 50230202 CHEMBL4063405 Carbonic anhydrase 4 Homo sapiens 8.8 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230202&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137637365 383542987 CHEMBL4063405 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678272 COc1ccc2cc(ccc2c1)[C@H](C)C(=O)NCCOc1ccc2ccc(=O)oc2c1 InChI=1S/C25H23NO5/c1-16(18-3-4-20-14-21(29-2)8-6-19(20)13-18)25(28)26-11-12-30-22-9-5-17-7-10-24(27)31-23(17)15-22/h3-10,13-16H,11-12H2,1-2H3,(H,26,28)/t16-/m0/s1 QDTHXIATRDGOIR-INIZCTEOSA-N 50230203 CHEMBL4067437 Carbonic anhydrase 4 Homo sapiens 9.8 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230203&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137631746 383542988 CHEMBL4067437 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678274 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678388 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)NCCOc3ccc4oc(=O)ccc4c3)c2c1 InChI=1S/C30H25ClN2O6/c1-18-24(17-28(34)32-13-14-38-23-9-11-27-20(15-23)5-12-29(35)39-27)25-16-22(37-2)8-10-26(25)33(18)30(36)19-3-6-21(31)7-4-19/h3-12,15-16H,13-14,17H2,1-2H3,(H,32,34) PBGGJNVDKZVPIY-UHFFFAOYSA-N 50230204 CHEMBL4079507 Carbonic anhydrase 4 Homo sapiens 2.6 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230204&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137651769 383542989 CHEMBL4079507 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678389 Clc1cccc(Cl)c1Nc1ccccc1CC(=O)NCCOc1ccc2oc(=O)ccc2c1 InChI=1S/C25H20Cl2N2O4/c26-19-5-3-6-20(27)25(19)29-21-7-2-1-4-16(21)15-23(30)28-12-13-32-18-9-10-22-17(14-18)8-11-24(31)33-22/h1-11,14,29H,12-13,15H2,(H,28,30) TXVQNFKIVJJNQQ-UHFFFAOYSA-N 50230207 CHEMBL4069089 Carbonic anhydrase 4 Homo sapiens 5.6 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230207&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137632743 383542992 CHEMBL4069089 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678390 COc1ccc2cc(ccc2c1)[C@H](C)C(=O)NCCOc1ccc2oc(=O)ccc2c1 InChI=1S/C25H23NO5/c1-16(17-3-4-19-14-21(29-2)7-5-18(19)13-17)25(28)26-11-12-30-22-8-9-23-20(15-22)6-10-24(27)31-23/h3-10,13-16H,11-12H2,1-2H3,(H,26,28)/t16-/m0/s1 LDQIHKKKXURECO-INIZCTEOSA-N 50230205 CHEMBL4088636 Carbonic anhydrase 4 Homo sapiens 0.730000 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230205&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137643949 383542990 CHEMBL4088636 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678392 CC(C)Cc1ccc(cc1)C(C)C(=O)NCCOc1ccc2ccc(=O)oc2c1 InChI=1S/C24H27NO4/c1-16(2)14-18-4-6-19(7-5-18)17(3)24(27)25-12-13-28-21-10-8-20-9-11-23(26)29-22(20)15-21/h4-11,15-17H,12-14H2,1-3H3,(H,25,27) XPVSTWDEGVQKPN-UHFFFAOYSA-N 50230208 CHEMBL4104094 Carbonic anhydrase 4 Homo sapiens 9.1 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230208&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137657759 383542993 CHEMBL4104094 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50678393 O=C(NCCOc1ccc2ccc(=O)oc2c1)C1CCn2c1ccc2C(=O)c1ccccc1 InChI=1S/C26H22N2O5/c29-24-11-7-17-6-8-19(16-23(17)33-24)32-15-13-27-26(31)20-12-14-28-21(20)9-10-22(28)25(30)18-4-2-1-3-5-18/h1-11,16,20H,12-15H2,(H,27,31) SUBMPIYHZWMMCK-UHFFFAOYSA-N 50230206 CHEMBL4094868 Carbonic anhydrase 4 Homo sapiens 9.4 ChEMBL 10.1021/acs.jmedchem.6b01607 10.7270/Q2PC34NX 28075587 Bua, S; Di Cesare Mannelli, L; Vullo, D; Ghelardini, C; Bartolucci, G; Scozzafava, A; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50230206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50230206&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137655450 383542991 CHEMBL4094868 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708290 NS(=O)(=O)c1ccc(CCN2C(=O)CCC2=O)cc1 InChI=1S/C12H14N2O4S/c13-19(17,18)10-3-1-9(2-4-10)7-8-14-11(15)5-6-12(14)16/h1-4H,5-8H2,(H2,13,17,18) QLNOPHDWPSAMRG-UHFFFAOYSA-N 50234450 CHEMBL1905680 Carbonic anhydrase 4 Homo sapiens 9578 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234450&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2316976 384584580 CHEMBL1905680 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708291 NS(=O)(=O)c1ccc(CCN2C(=O)C=CC2=O)cc1 InChI=1S/C12H12N2O4S/c13-19(17,18)10-3-1-9(2-4-10)7-8-14-11(15)5-6-12(14)16/h1-6H,7-8H2,(H2,13,17,18) VEQRFGXBRWISPW-UHFFFAOYSA-N 50234460 CHEMBL4096617 Carbonic anhydrase 4 Homo sapiens 4849 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234460&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 54940826 384584590 CHEMBL4096617 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708292 NS(=O)(=O)c1ccc(CCN2C(=O)c3nccnc3C2=O)cc1 InChI=1S/C14H12N4O4S/c15-23(21,22)10-3-1-9(2-4-10)5-8-18-13(19)11-12(14(18)20)17-7-6-16-11/h1-4,6-7H,5,8H2,(H2,15,21,22) ZLLASSKSYROVGB-UHFFFAOYSA-N 50234459 CHEMBL4083255 Carbonic anhydrase 4 Homo sapiens 9380 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234459&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137646284 384584589 CHEMBL4083255 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708348 NS(=O)(=O)c1ccc(CCN2C(=O)c3ccccc3C2=O)cc1 InChI=1S/C16H14N2O4S/c17-23(21,22)12-7-5-11(6-8-12)9-10-18-15(19)13-3-1-2-4-14(13)16(18)20/h1-8H,9-10H2,(H2,17,21,22) JGFAPAGLUNJXRJ-UHFFFAOYSA-N 50234458 CHEMBL4101260 Carbonic anhydrase 4 Homo sapiens 5461 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234458&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 17774014 384584588 CHEMBL4101260 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708349 Cc1ccc2C(=O)N(CCc3ccc(cc3)S(N)(=O)=O)C(=O)c2c1 InChI=1S/C17H16N2O4S/c1-11-2-7-14-15(10-11)17(21)19(16(14)20)9-8-12-3-5-13(6-4-12)24(18,22)23/h2-7,10H,8-9H2,1H3,(H2,18,22,23) KAOLALHCOGPKHQ-UHFFFAOYSA-N 50234457 CHEMBL4091049 Carbonic anhydrase 4 Homo sapiens 2925 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234457&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137644957 384584587 CHEMBL4091049 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708350 NS(=O)(=O)c1ccc(CCN2C(=O)c3cc(Cl)c(Cl)cc3C2=O)cc1 InChI=1S/C16H12Cl2N2O4S/c17-13-7-11-12(8-14(13)18)16(22)20(15(11)21)6-5-9-1-3-10(4-2-9)25(19,23)24/h1-4,7-8H,5-6H2,(H2,19,23,24) OVPPVEJAESVMOD-UHFFFAOYSA-N 50234456 CHEMBL4064210 Carbonic anhydrase 4 Homo sapiens 9358 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234456&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137636505 384584586 CHEMBL4064210 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708351 NS(=O)(=O)c1ccc(CCN2C(=O)c3c(C2=O)c(Cl)c(Cl)c(Cl)c3Cl)cc1 InChI=1S/C16H10Cl4N2O4S/c17-11-9-10(12(18)14(20)13(11)19)16(24)22(15(9)23)6-5-7-1-3-8(4-2-7)27(21,25)26/h1-4H,5-6H2,(H2,21,25,26) GNOITBWORAUPOH-UHFFFAOYSA-N 50234455 CHEMBL2414438 Carbonic anhydrase 4 Homo sapiens 9232 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234455&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 71770179 384584585 CHEMBL2414438 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708352 NS(=O)(=O)c1ccc(CCN2C(=O)c3ccc(cc3C2=O)[N+]([O-])=O)cc1 InChI=1S/C16H13N3O6S/c17-26(24,25)12-4-1-10(2-5-12)7-8-18-15(20)13-6-3-11(19(22)23)9-14(13)16(18)21/h1-6,9H,7-8H2,(H2,17,24,25) NGYUNTRTFWIHLQ-UHFFFAOYSA-N 50234462 CHEMBL3113927 Carbonic anhydrase 4 Homo sapiens 8175 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234462&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 76328576 384584592 CHEMBL3113927 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708353 NS(=O)(=O)c1ccc(CCN2C(=O)c3cccc(c3C2=O)[N+]([O-])=O)cc1 InChI=1S/C16H13N3O6S/c17-26(24,25)11-6-4-10(5-7-11)8-9-18-15(20)12-2-1-3-13(19(22)23)14(12)16(18)21/h1-7H,8-9H2,(H2,17,24,25) WCJMFBWEOBUTTC-UHFFFAOYSA-N 50234453 CHEMBL4080077 Carbonic anhydrase 4 Homo sapiens 8517 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234453&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 132961427 384584583 CHEMBL4080077 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708354 NS(=O)(=O)c1ccc(cc1)N1C(=O)C2C(C1=O)C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl InChI=1S/C15H8Cl6N2O4S/c16-9-10(17)14(19)8-7(13(9,18)15(14,20)21)11(24)23(12(8)25)5-1-3-6(4-2-5)28(22,26)27/h1-4,7-8H,(H2,22,26,27) WNSRJXQPIDSREG-UHFFFAOYSA-N 50234452 CHEMBL4066940 Carbonic anhydrase 4 Homo sapiens 83 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234452&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 228958 384584582 CHEMBL4066940 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708355 NS(=O)(=O)c1ccc(CCN2C(=O)C3C(C2=O)C2(Cl)C(Cl)=C(Cl)C3(Cl)C2(Cl)Cl)cc1 InChI=1S/C17H12Cl6N2O4S/c18-11-12(19)16(21)10-9(15(11,20)17(16,22)23)13(26)25(14(10)27)6-5-7-1-3-8(4-2-7)30(24,28)29/h1-4,9-10H,5-6H2,(H2,24,28,29) HJGDRSSZNLREKX-UHFFFAOYSA-N 50234451 CHEMBL4103944 Carbonic anhydrase 4 Homo sapiens 6764 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234451&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137658271 384584581 CHEMBL4103944 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708356 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708803 NS(=O)(=O)c1ccc(CCN2C(=O)[C@H]3CC=CC[C@H]3C2=O)cc1 InChI=1S/C16H18N2O4S/c17-23(21,22)12-7-5-11(6-8-12)9-10-18-15(19)13-3-1-2-4-14(13)16(18)20/h1-2,5-8,13-14H,3-4,9-10H2,(H2,17,21,22)/t13-,14+ ISJWIYIDVJBCDZ-OKILXGFUSA-N 50234449 CHEMBL4078596 Carbonic anhydrase 4 Homo sapiens 973 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234449&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 132961426 384584579 CHEMBL4078596 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708804 CC(C)(C)c1ccc2C(=O)N(CCc3ccc(cc3)S(N)(=O)=O)C(=O)c2c1 InChI=1S/C20H22N2O4S/c1-20(2,3)14-6-9-16-17(12-14)19(24)22(18(16)23)11-10-13-4-7-15(8-5-13)27(21,25)26/h4-9,12H,10-11H2,1-3H3,(H2,21,25,26) KHDDWTQSLGVKIK-UHFFFAOYSA-N 50234461 CHEMBL4063164 Carbonic anhydrase 4 Homo sapiens 9391 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234461&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137635300 384584591 CHEMBL4063164 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708805 NS(=O)(=O)c1ccc(CCN2C(=O)c3c(C2=O)c(Br)c(Br)c(Br)c3Br)cc1 InChI=1S/C16H10Br4N2O4S/c17-11-9-10(12(18)14(20)13(11)19)16(24)22(15(9)23)6-5-7-1-3-8(4-2-7)27(21,25)26/h1-4H,5-6H2,(H2,21,25,26) BZYJAFXEUBCXBJ-UHFFFAOYSA-N 50234454 CHEMBL2424832 Carbonic anhydrase 4 Homo sapiens 8839 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234454&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 72163344 384584584 CHEMBL2424832 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50708806 NS(=O)(=O)c1ccc(CN2C(=O)C3C(C2=O)C2(Cl)C(Cl)=C(Cl)C3(Cl)C2(Cl)Cl)cc1 InChI=1S/C16H10Cl6N2O4S/c17-10-11(18)15(20)9-8(14(10,19)16(15,21)22)12(25)24(13(9)26)5-6-1-3-7(4-2-6)29(23,27)28/h1-4,8-9H,5H2,(H2,23,27,28) RLFLFPCKSKIEKK-UHFFFAOYSA-N 50234448 CHEMBL4079688 Carbonic anhydrase 4 Homo sapiens 912 ChEMBL 10.1016/j.bmc.2017.01.032 10.7270/Q2C53P22 28161252 Abdel-Aziz, AA; Angeli, A; El-Azab, AS; Abu El-Enin, MA; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234448&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137650823 384584578 CHEMBL4079688 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725430 CC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(Cl)cc4)c3c(=O)n12)-c1cccs1 InChI=1S/C26H17ClN6O4S2/c1-14(34)24-31-33(17-8-10-18(11-9-17)39(28,36)37)26-30-23-22(25(35)32(24)26)19(15-4-6-16(27)7-5-15)13-20(29-23)21-3-2-12-38-21/h2-13H,1H3,(H2,28,36,37) FHMXPAZCYYUXLD-UHFFFAOYSA-N 50235676 CHEMBL4089713 Carbonic anhydrase 4 Homo sapiens 2520 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235676&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137643724 384991462 CHEMBL4089713 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725434 CC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(F)cc4)c3c(=O)n12)-c1cccs1 InChI=1S/C26H17FN6O4S2/c1-14(34)24-31-33(17-8-10-18(11-9-17)39(28,36)37)26-30-23-22(25(35)32(24)26)19(15-4-6-16(27)7-5-15)13-20(29-23)21-3-2-12-38-21/h2-13H,1H3,(H2,28,36,37) KOVLYFSPCIKXRP-UHFFFAOYSA-N 50235677 CHEMBL4093086 Carbonic anhydrase 4 Homo sapiens 2450 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235677&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137654917 384991463 CHEMBL4093086 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725435 CCOC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(F)cc4)c3c(=O)n12)-c1cccs1 InChI=1S/C27H19FN6O5S2/c1-2-39-26(36)24-32-34(17-9-11-18(12-10-17)41(29,37)38)27-31-23-22(25(35)33(24)27)19(15-5-7-16(28)8-6-15)14-20(30-23)21-4-3-13-40-21/h3-14H,2H2,1H3,(H2,29,37,38) XMDVIFRHQPMKOK-UHFFFAOYSA-N 50235678 CHEMBL4061590 Carbonic anhydrase 4 Homo sapiens 3960 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235678&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137634549 384991464 CHEMBL4061590 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725473 CCOC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(Cl)cc4)c3c(=O)n12)-c1cccs1 InChI=1S/C27H19ClN6O5S2/c1-2-39-26(36)24-32-34(17-9-11-18(12-10-17)41(29,37)38)27-31-23-22(25(35)33(24)27)19(15-5-7-16(28)8-6-15)14-20(30-23)21-4-3-13-40-21/h3-14H,2H2,1H3,(H2,29,37,38) GYRCGIBEVYGNAC-UHFFFAOYSA-N 50235687 CHEMBL4096540 Carbonic anhydrase 4 Homo sapiens 4330 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235687&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137652940 384991473 CHEMBL4096540 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725474 COc1ccc(cc1)-c1cc(nc2nc3n(nc(C(C)=O)n3c(=O)c12)-c1ccc(cc1)S(N)(=O)=O)-c1cccs1 InChI=1S/C27H20N6O5S2/c1-15(34)25-31-33(17-7-11-19(12-8-17)40(28,36)37)27-30-24-23(26(35)32(25)27)20(16-5-9-18(38-2)10-6-16)14-21(29-24)22-4-3-13-39-22/h3-14H,1-2H3,(H2,28,36,37) WYEKATGEEIIFLU-UHFFFAOYSA-N 50235688 CHEMBL4078512 Carbonic anhydrase 4 Homo sapiens 2230 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235688&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137649373 384991474 CHEMBL4078512 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725480 CCOC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(OC)cc4)c3c(=O)n12)-c1cccs1 InChI=1S/C28H22N6O6S2/c1-3-40-27(36)25-32-34(17-8-12-19(13-9-17)42(29,37)38)28-31-24-23(26(35)33(25)28)20(16-6-10-18(39-2)11-7-16)15-21(30-24)22-5-4-14-41-22/h4-15H,3H2,1-2H3,(H2,29,37,38) PBNLXMUVJBVBKZ-UHFFFAOYSA-N 50235692 CHEMBL4088844 Carbonic anhydrase 4 Homo sapiens 4250 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235692&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137642310 384991478 CHEMBL4088844 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725481 CC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(cc4)[N+]([O-])=O)c3c(=O)n12)-c1cccs1 InChI=1S/C26H17N7O6S2/c1-14(34)24-30-32(16-8-10-18(11-9-16)41(27,38)39)26-29-23-22(25(35)31(24)26)19(13-20(28-23)21-3-2-12-40-21)15-4-6-17(7-5-15)33(36)37/h2-13H,1H3,(H2,27,38,39) JMWNCVXIRFFUJT-UHFFFAOYSA-N 50235693 CHEMBL4067617 Carbonic anhydrase 4 Homo sapiens 200 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235693&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137632115 384991479 CHEMBL4067617 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725482 CCOC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(cc4)[N+]([O-])=O)c3c(=O)n12)-c1cccs1 InChI=1S/C27H19N7O7S2/c1-2-41-26(36)24-31-33(16-9-11-18(12-10-16)43(28,39)40)27-30-23-22(25(35)32(24)27)19(14-20(29-23)21-4-3-13-42-21)15-5-7-17(8-6-15)34(37)38/h3-14H,2H2,1H3,(H2,28,39,40) AKMXJPBORPRBLQ-UHFFFAOYSA-N 50235679 CHEMBL4066599 Carbonic anhydrase 4 Homo sapiens 2980 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235679&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137634142 384991465 CHEMBL4066599 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725483 Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) RZEKVGVHFLEQIL-UHFFFAOYSA-N 11639 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide::CHEMBL118::CLX::Celebrex::Celecoxib::US10322118, Urea-Based Scaffold Entry 9::US11478464, Compound Celecoxib::US8741944, Comparative Compound::US9388139, Celecoxib::cid_2662 Carbonic anhydrase 4 Homo sapiens 290 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11639&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CEL 3LN1,3KK6,5JW1,7ZEJ,4FIM,1OQ5 2662 46512162 41423 CHEMBL118 DB00482 2892 C07589 ZINC02570895 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725486 CC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccccc4)c3c(=O)n12)-c1ccc(Cl)cc1 InChI=1S/C28H19ClN6O4S/c1-16(36)26-33-35(20-11-13-21(14-12-20)40(30,38)39)28-32-25-24(27(37)34(26)28)22(17-5-3-2-4-6-17)15-23(31-25)18-7-9-19(29)10-8-18/h2-15H,1H3,(H2,30,38,39) XHWUKVQPEYWLPH-UHFFFAOYSA-N 50235680 CHEMBL4090671 Carbonic anhydrase 4 Homo sapiens 3000 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235680&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 132569639 384991466 CHEMBL4090671 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725487 CC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(Cl)cc4)c3c(=O)n12)-c1ccc(Cl)cc1 InChI=1S/C28H18Cl2N6O4S/c1-15(37)26-34-36(20-10-12-21(13-11-20)41(31,39)40)28-33-25-24(27(38)35(26)28)22(16-2-6-18(29)7-3-16)14-23(32-25)17-4-8-19(30)9-5-17/h2-14H,1H3,(H2,31,39,40) MUCXCXFAVQHGMN-UHFFFAOYSA-N 50235690 CHEMBL4059980 Carbonic anhydrase 4 Homo sapiens 3560 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235690&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137636775 384991476 CHEMBL4059980 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725488 CCOC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(Cl)cc4)c3c(=O)n12)-c1ccc(Cl)cc1 InChI=1S/C29H20Cl2N6O5S/c1-2-42-28(39)26-35-37(20-11-13-21(14-12-20)43(32,40)41)29-34-25-24(27(38)36(26)29)22(16-3-7-18(30)8-4-16)15-23(33-25)17-5-9-19(31)10-6-17/h3-15H,2H2,1H3,(H2,32,40,41) ISJXWDYGNRAKBD-UHFFFAOYSA-N 50235675 CHEMBL4074030 Carbonic anhydrase 4 Homo sapiens 4700 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235675&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137640627 384991461 CHEMBL4074030 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725489 COc1ccc(cc1)-c1cc(nc2nc3n(nc(C(C)=O)n3c(=O)c12)-c1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1 InChI=1S/C29H21ClN6O5S/c1-16(37)27-34-36(20-9-13-22(14-10-20)42(31,39)40)29-33-26-25(28(38)35(27)29)23(17-5-11-21(41-2)12-6-17)15-24(32-26)18-3-7-19(30)8-4-18/h3-15H,1-2H3,(H2,31,39,40) SMVILGFFGMAYRD-UHFFFAOYSA-N 50235684 CHEMBL4100795 Carbonic anhydrase 4 Homo sapiens 3010 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235684&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137659342 384991470 CHEMBL4100795 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725544 CCOC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccccc4)c3c(=O)n12)-c1ccc(Cl)cc1 InChI=1S/C29H21ClN6O5S/c1-2-41-28(38)26-34-36(20-12-14-21(15-13-20)42(31,39)40)29-33-25-24(27(37)35(26)29)22(17-6-4-3-5-7-17)16-23(32-25)18-8-10-19(30)11-9-18/h3-16H,2H2,1H3,(H2,31,39,40) HFQMXZLQLQQCKS-UHFFFAOYSA-N 50235681 CHEMBL4060983 Carbonic anhydrase 4 Homo sapiens 4620 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235681&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137635430 384991467 CHEMBL4060983 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725545 CC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(F)cc4)c3c(=O)n12)-c1ccc(Cl)cc1 InChI=1S/C28H18ClFN6O4S/c1-15(37)26-34-36(20-10-12-21(13-11-20)41(31,39)40)28-33-25-24(27(38)35(26)28)22(16-4-8-19(30)9-5-16)14-23(32-25)17-2-6-18(29)7-3-17/h2-14H,1H3,(H2,31,39,40) DBWMLBRAKAXKTP-UHFFFAOYSA-N 50235694 CHEMBL4095288 Carbonic anhydrase 4 Homo sapiens 3580 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235694&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137653117 384991480 CHEMBL4095288 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725546 CCOC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(F)cc4)c3c(=O)n12)-c1ccc(Cl)cc1 InChI=1S/C29H20ClFN6O5S/c1-2-42-28(39)26-35-37(20-11-13-21(14-12-20)43(32,40)41)29-34-25-24(27(38)36(26)29)22(16-5-9-19(31)10-6-16)15-23(33-25)17-3-7-18(30)8-4-17/h3-15H,2H2,1H3,(H2,32,40,41) CRVMZHXYLKYHEP-UHFFFAOYSA-N 50235691 CHEMBL4088226 Carbonic anhydrase 4 Homo sapiens 4900 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235691&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137644641 384991477 CHEMBL4088226 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725550 CC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(cc4)[N+]([O-])=O)c3c(=O)n12)-c1ccc(Cl)cc1 InChI=1S/C28H18ClN7O6S/c1-15(37)26-33-35(19-10-12-21(13-11-19)43(30,41)42)28-32-25-24(27(38)34(26)28)22(16-4-8-20(9-5-16)36(39)40)14-23(31-25)17-2-6-18(29)7-3-17/h2-14H,1H3,(H2,30,41,42) UWAUWBRWRNCNBI-UHFFFAOYSA-N 50235683 CHEMBL4062664 Carbonic anhydrase 4 Homo sapiens 2920 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235683&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137635055 384991469 CHEMBL4062664 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725551 CCOC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccc(cc4)[N+]([O-])=O)c3c(=O)n12)-c1ccc(Cl)cc1 InChI=1S/C29H20ClN7O7S/c1-2-44-28(39)26-34-36(19-11-13-21(14-12-19)45(31,42)43)29-33-25-24(27(38)35(26)29)22(16-5-9-20(10-6-16)37(40)41)15-23(32-25)17-3-7-18(30)8-4-17/h3-15H,2H2,1H3,(H2,31,42,43) LTVDAIYNTVRBTA-UHFFFAOYSA-N 50235686 CHEMBL4103258 Carbonic anhydrase 4 Homo sapiens 3560 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235686&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137658239 384991472 CHEMBL4103258 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725552 CC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3nc(cc(-c4ccccc4)c3c(=O)n12)-c1cccs1 InChI=1S/C26H18N6O4S2/c1-15(33)24-30-32(17-9-11-18(12-10-17)38(27,35)36)26-29-23-22(25(34)31(24)26)19(16-6-3-2-4-7-16)14-20(28-23)21-8-5-13-37-21/h2-14H,1H3,(H2,27,35,36) KCERDJVEAQJEHU-UHFFFAOYSA-N 50235689 CHEMBL3288908 Carbonic anhydrase 4 Homo sapiens 4790 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235689&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 90681501 384991475 CHEMBL3288908 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50725556 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 70 ChEMBL 10.1016/j.bmc.2017.02.037 10.7270/Q2SX6GGD 28256371 Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778025 O[Se](=O)c1ccccc1 InChI=1S/C6H6O2Se/c7-9(8)6-4-2-1-3-5-6/h1-5H,(H,7,8) WIHKGDVGLJJAMC-UHFFFAOYSA-N 50028972 Benzene Selenoic Acid Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028972&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 23427 313065618 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778026 COc1ccc(cc1)C1C[Se]c2ccccc2N1S(=O)(=O)c1ccc(C)cc1 InChI=1S/C22H21NO3SSe/c1-16-7-13-19(14-8-16)27(24,25)23-20-5-3-4-6-22(20)28-15-21(23)17-9-11-18(26-2)12-10-17/h3-14,21H,15H2,1-2H3 CCEYPQYVQDKWDN-UHFFFAOYSA-N 50248424 CHEMBL4085066 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248424&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 101564149 401961248 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778027 COc1ccc(cc1)C1C[Se]c2ccc(Cl)cc2N1S(=O)(=O)c1ccc(C)cc1 InChI=1S/C22H20ClNO3SSe/c1-15-3-10-19(11-4-15)28(25,26)24-20-13-17(23)7-12-22(20)29-14-21(24)16-5-8-18(27-2)9-6-16/h3-13,21H,14H2,1-2H3 RMODCRJTRNQQRD-UHFFFAOYSA-N 50248607 CHEMBL4077579 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248607&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 132547793 401961266 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778028 Cc1ccc(cc1)S(=O)(=O)N1C2OCCC2[Se]c2ccccc12 InChI=1S/C17H17NO3SSe/c1-12-6-8-13(9-7-12)22(19,20)18-14-4-2-3-5-15(14)23-16-10-11-21-17(16)18/h2-9,16-17H,10-11H2,1H3 MPKIHLSBWNUPRD-UHFFFAOYSA-N 50248466 CHEMBL4101501 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248466&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137661006 401961250 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778029 COc1ccc(cc1)C1C[Se]c2ccccc2N1S(=O)(=O)c1ccccc1[N+]([O-])=O InChI=1S/C21H18N2O5SSe/c1-28-16-12-10-15(11-13-16)19-14-30-21-9-5-3-7-18(21)22(19)29(26,27)20-8-4-2-6-17(20)23(24)25/h2-13,19H,14H2,1H3 JRDBPSCAKAOXBD-UHFFFAOYSA-N 50248467 CHEMBL4076253 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248467&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137650698 401961251 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778030 CC(C)C[C@@H](C[Se][Se]C[C@H](CC(C)C)NS(=O)(=O)c1ccc(C)cc1)NS(=O)(=O)c1ccc(C)cc1 InChI=1S/C26H40N2O4S2Se2/c1-19(2)15-23(27-33(29,30)25-11-7-21(5)8-12-25)17-35-36-18-24(16-20(3)4)28-34(31,32)26-13-9-22(6)10-14-26/h7-14,19-20,23-24,27-28H,15-18H2,1-6H3/t23-,24-/m0/s1 SQEXWKCCTMLOMX-ZEQRLZLVSA-N 50248468 CHEMBL4095150 Carbonic anhydrase 4 Homo sapiens 23500 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248468&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 102151146 401961252 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778031 CC(C)C[C@@H](C[Se]c1ccccc1)NS(=O)(=O)c1ccc(C)cc1 InChI=1S/C19H25NO2SSe/c1-15(2)13-17(14-24-19-7-5-4-6-8-19)20-23(21,22)18-11-9-16(3)10-12-18/h4-12,15,17,20H,13-14H2,1-3H3/t17-/m0/s1 LOYIXSPTTWITNQ-KRWDZBQOSA-N 50248512 CHEMBL4067403 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248512&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 102311866 401961253 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778038 Cc1ccc(cc1)S(=O)(=O)Nc1cc(C)ccc1[Se][Se]c1ccc(C)cc1NS(=O)(=O)c1ccc(C)cc1 InChI=1S/C28H28N2O4S2Se2/c1-19-5-11-23(12-6-19)35(31,32)29-25-17-21(3)9-15-27(25)37-38-28-16-10-22(4)18-26(28)30-36(33,34)24-13-7-20(2)8-14-24/h5-18,29-30H,1-4H3 PQLDISKCBJFIRV-UHFFFAOYSA-N 50248564 CHEMBL4069637 Carbonic anhydrase 4 Homo sapiens 78900 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248564&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137639833 401961264 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778041 Oc1ccc(cc1)-c1cc2c(Cl)c(O)c(Cl)c(O)c2[se]1 InChI=1S/C14H8Cl2O3Se/c15-10-8-5-9(6-1-3-7(17)4-2-6)20-14(8)13(19)11(16)12(10)18/h1-5,17-19H ZEALFPKSZBYHID-UHFFFAOYSA-N 50248421 CHEMBL4101066 Carbonic anhydrase 4 Homo sapiens 52400 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248421&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 122226187 401961245 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778056 OC(COCc1ccccc1)C[Se]CC(O)COCc1ccccc1 InChI=1S/C20H26O4Se/c21-19(13-23-11-17-7-3-1-4-8-17)15-25-16-20(22)14-24-12-18-9-5-2-6-10-18/h1-10,19-22H,11-16H2 KJPDJIMZBYZNSR-UHFFFAOYSA-N 50248561 CHEMBL4083092 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248561&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 122386532 401961261 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778058 Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1[Se][Se]c1ccccc1NS(=O)(=O)c1ccc(C)cc1 InChI=1S/C26H24N2O4S2Se2/c1-19-11-15-21(16-12-19)33(29,30)27-23-7-3-5-9-25(23)35-36-26-10-6-4-8-24(26)28-34(31,32)22-17-13-20(2)14-18-22/h3-18,27-28H,1-2H3 JMHGQKYPTKBXCO-UHFFFAOYSA-N 50248515 CHEMBL4082845 Carbonic anhydrase 4 Homo sapiens 6200 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248515&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5272990 401961256 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778062 OC(COCc1ccccc1)C[Se]c1ccccc1 InChI=1S/C16H18O2Se/c17-15(13-19-16-9-5-2-6-10-16)12-18-11-14-7-3-1-4-8-14/h1-10,15,17H,11-13H2 MOSGUYVWZWXILV-UHFFFAOYSA-N 50248565 CHEMBL4099304 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248565&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11034581 401961265 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778063 [O-][N+](=O)c1ccccc1[Se][Se]c1ccccc1[N+]([O-])=O InChI=1S/C12H8N2O4Se2/c15-13(16)9-5-1-3-7-11(9)19-20-12-8-4-2-6-10(12)14(17)18/h1-8H QUTPYNJBIHTIGA-UHFFFAOYSA-N 50248563 CHEMBL4059960 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248563&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 101424 401961263 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778105 Cc1ccc(cc1)S(=O)(=O)N[C@H](C[Se][Se]C[C@H](Cc1ccccc1)NS(=O)(=O)c1ccc(C)cc1)Cc1ccccc1 InChI=1S/C32H36N2O4S2Se2/c1-25-13-17-31(18-14-25)39(35,36)33-29(21-27-9-5-3-6-10-27)23-41-42-24-30(22-28-11-7-4-8-12-28)34-40(37,38)32-19-15-26(2)16-20-32/h3-20,29-30,33-34H,21-24H2,1-2H3/t29-,30-/m0/s1 DQLMPACNTUYQMO-KYJUHHDHSA-N 50248562 CHEMBL4073396 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248562&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 102151151 401961262 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778112 COc1ccc(cc1)C1C[Se]c2ccc(Cl)cc2N1S(=O)(=O)c1ccccc1[N+]([O-])=O InChI=1S/C21H17ClN2O5SSe/c1-29-16-9-6-14(7-10-16)19-13-31-21-11-8-15(22)12-18(21)23(19)30(27,28)20-5-3-2-4-17(20)24(25)26/h2-12,19H,13H2,1H3 GNFJQMZESLSJGU-UHFFFAOYSA-N 50248465 CHEMBL4063436 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248465&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 132547798 401961249 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778118 COc1ccc(cc1O)C(O)C[Se][Se]CC(O)c1ccc(OC)c(O)c1 InChI=1S/C18H22O6Se2/c1-23-17-5-3-11(7-13(17)19)15(21)9-25-26-10-16(22)12-4-6-18(24-2)14(20)8-12/h3-8,15-16,19-22H,9-10H2,1-2H3 WTLXCTPHASXPJI-UHFFFAOYSA-N 50248516 CHEMBL4090651 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248516&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137642864 401961257 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778126 Cc1ccc([Se][Se]c2ccc(C)cc2N)c(N)c1 InChI=1S/C14H16N2Se2/c1-9-3-5-13(11(15)7-9)17-18-14-6-4-10(2)8-12(14)16/h3-8H,15-16H2,1-2H3 YJFPJDBLZBDYJW-UHFFFAOYSA-N 50248514 CHEMBL4060965 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248514&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137634525 401961255 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778133 OC(COCc1ccccc1)C[Se][Se]CC(O)COCc1ccccc1 InChI=1S/C20H26O4Se2/c21-19(13-23-11-17-7-3-1-4-8-17)15-25-26-16-20(22)14-24-12-18-9-5-2-6-10-18/h1-10,19-22H,11-16H2 RYTFMNMRUPCSSC-UHFFFAOYSA-N 50248560 CHEMBL4072353 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248560&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 102480165 401961260 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778151 Oc1ccc(cc1)-c1cc2cc(O)cc(O)c2[se]1 InChI=1S/C14H10O3Se/c15-10-3-1-8(2-4-10)13-6-9-5-11(16)7-12(17)14(9)18-13/h1-7,15-17H NXNJSGIETCZVFQ-UHFFFAOYSA-N 50248423 CHEMBL4104399 Carbonic anhydrase 4 Homo sapiens 56800 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248423&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 122226189 401961247 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778163 CC(C)[C@@H](C[Se]C[C@@H](NS(=O)(=O)c1ccc(C)cc1)C(C)C)NS(=O)(=O)c1ccc(C)cc1 InChI=1S/C24H36N2O4S2Se/c1-17(2)23(25-31(27,28)21-11-7-19(5)8-12-21)15-33-16-24(18(3)4)26-32(29,30)22-13-9-20(6)10-14-22/h7-14,17-18,23-26H,15-16H2,1-6H3/t23-,24-/m1/s1 NJTRGQHOMMWIHW-DNQXCXABSA-N 50248513 CHEMBL4088203 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248513&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 137643671 401961254 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778168 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778176 Oc1ccccc1[Se][Se]c1ccccc1O InChI=1S/C12H10O2Se2/c13-9-5-1-3-7-11(9)15-16-12-8-4-2-6-10(12)14/h1-8,13-14H WXLMISPTCQITOI-UHFFFAOYSA-N 50248517 CHEMBL3314696 Carbonic anhydrase 4 Homo sapiens 26600 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248517&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5272997 401961258 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778180 CC(O)C[Se]c1ccccc1 InChI=1S/C9H12OSe/c1-8(10)7-11-9-5-3-2-4-6-9/h2-6,8,10H,7H2,1H3 QZYCRLZJNSHFKJ-UHFFFAOYSA-N 50248559 CHEMBL4063762 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248559&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11183499 401961259 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50778184 Oc1ccc(cc1)-c1cc2c(Cl)c(O)cc(O)c2[se]1 InChI=1S/C14H9ClO3Se/c15-13-9-5-12(7-1-3-8(16)4-2-7)19-14(9)11(18)6-10(13)17/h1-6,16-18H VINSAJMEZSKTRY-UHFFFAOYSA-N 50248422 CHEMBL4086505 Carbonic anhydrase 4 Homo sapiens 9100 ChEMBL 10.1016/j.bmc.2017.03.013 10.7270/Q25B04XC 28302505 Angeli, A; Tanini, D; Viglianisi, C; Panzella, L; Capperucci, A; Menichetti, S; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248422&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 122226188 401961246 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50830982 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 GXJABQQUPOEUTA-RDJZCZTQSA-N 50069989 (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid::(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid::BORTEZOMIB::CHEMBL325041::Dipeptidyl boronic acid derivative::LDP-341::N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE::PS-341::Peptidyl boronic acid derivative::US11542283, Compound Velcade::Velcade::cid_387447 Carbonic anhydrase 4 Homo sapiens 6510 ChEMBL 10.1016/j.bmc.2016.10.023 10.7270/Q24170HK 28277280 Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069989&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BO2 4QVY,4QVN,4QVM,4QVL,3MG0,5L66,4QWU,4QW0,4QW1,4QW3,6TD5,2F16,5D0X,4QVW,4QVV,4QVQ,4QVP,5L5F,5L5Z,7KRZ,6HWM,6HWD,7LXT,6X27,4YPM,5BXN,5LF3,7Q0Y,8DVH,5CZ7,4FWD 387447 103963945 52717 CHEMBL325041 DB00188 6391 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50830983 OB(O)c1ccccc1 InChI=1S/C6H7BO2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9H HXITXNWTGFUOAU-UHFFFAOYSA-N 26996 CHEMBL21485::PhB(OH)2::Phenyl-boronic acid::Phenylboronic acid, 22::benzeneboronic acid::phenylboranediol::phenylboronic acid Carbonic anhydrase 4 Homo sapiens 880 ChEMBL 10.1016/j.bmc.2016.10.023 10.7270/Q24170HK 28277280 Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26996&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PBC 6VIM,1JU3,6UQU,4OB0,2A32 66827 57298706 44923 CHEMBL21485 DB01795 C16200 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50830984 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2016.10.023 10.7270/Q24170HK 28277280 Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988796 CC(=C)[C@@H]1CCC(C)(O)C(C1)[Se]c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H23NO3SSe/c1-11(2)12-8-9-16(3,18)15(10-12)22-14-6-4-13(5-7-14)21(17,19)20/h4-7,12,15,18H,1,8-10H2,2-3H3,(H2,17,19,20)/t12-,15?,16?/m1/s1 QWLCRIPOQCRMKJ-UWTIGNOOSA-N 50279697 CHEMBL4164295 Carbonic anhydrase 4 Homo sapiens 35 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279697&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145960287 406793933 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988812 CC(C)OCC(O)C[Se]c1ccc(cc1)S(N)(=O)=O InChI=1S/C12H19NO4SSe/c1-9(2)17-7-10(14)8-19-12-5-3-11(4-6-12)18(13,15)16/h3-6,9-10,14H,7-8H2,1-2H3,(H2,13,15,16) UJDDGCWBOZHHHS-UHFFFAOYSA-N 50279695 CHEMBL4160510 Carbonic anhydrase 4 Homo sapiens 403 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279695&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145959905 406793931 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988816 NS(=O)(=O)c1ccc([Se]C2CCCCC2O)cc1 InChI=1S/C12H17NO3SSe/c13-17(15,16)9-5-7-10(8-6-9)18-12-4-2-1-3-11(12)14/h5-8,11-12,14H,1-4H2,(H2,13,15,16) RLHADEWYOBUONX-UHFFFAOYSA-N 50279712 CHEMBL4172182 Carbonic anhydrase 4 Homo sapiens 458 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279712&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145952239 406793940 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988833 CC(C)[C@@H](C[Se]c1ccc(cc1)S(N)(=O)=O)NS(=O)(=O)c1ccc(C)cc1 InChI=1S/C18H24N2O4S2Se/c1-13(2)18(20-26(23,24)16-6-4-14(3)5-7-16)12-27-17-10-8-15(9-11-17)25(19,21)22/h4-11,13,18,20H,12H2,1-3H3,(H2,19,21,22)/t18-/m1/s1 XDBWUTHSNGQTNQ-GOSISDBHSA-N 50279714 CHEMBL4162168 Carbonic anhydrase 4 Homo sapiens 435 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279714&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145959957 406793942 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988865 NS(=O)(=O)c1ccc([Se]C#N)cc1 InChI=1S/C7H6N2O2SSe/c8-5-13-7-3-1-6(2-4-7)12(9,10)11/h1-4H,(H2,9,10,11) NIPVOZTXTNRTJG-UHFFFAOYSA-N 50279713 CHEMBL4159870 Carbonic anhydrase 4 Homo sapiens 31 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279713&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145957136 406793941 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988866 NS(=O)(=O)c1ccc([Se][Se]c2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C12H12N2O4S2Se2/c13-19(15,16)9-1-5-11(6-2-9)21-22-12-7-3-10(4-8-12)20(14,17)18/h1-8H,(H2,13,15,16)(H2,14,17,18) HSNPAACMOXRSQS-UHFFFAOYSA-N 50279705 CHEMBL4161289 Carbonic anhydrase 4 Homo sapiens 298 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279705&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 119082247 406793935 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988868 NS(=O)(=O)c1ccc([Se]CC(O)COCC=C)cc1 InChI=1S/C12H17NO4SSe/c1-2-7-17-8-10(14)9-19-12-5-3-11(4-6-12)18(13,15)16/h2-6,10,14H,1,7-9H2,(H2,13,15,16) WGOGLMWHOUAANB-UHFFFAOYSA-N 50279694 CHEMBL4171114 Carbonic anhydrase 4 Homo sapiens 8133 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279694&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949393 406793930 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988870 CCCCC(O)C[Se]c1ccc(cc1)S(N)(=O)=O InChI=1S/C12H19NO3SSe/c1-2-3-4-10(14)9-18-12-7-5-11(6-8-12)17(13,15)16/h5-8,10,14H,2-4,9H2,1H3,(H2,13,15,16) CZMINFMVXRJOMD-UHFFFAOYSA-N 50279704 CHEMBL4166046 Carbonic anhydrase 4 Homo sapiens 429 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279704&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145952880 406793934 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988871 NS(=O)(=O)c1ccc([Se]CC(O)CBr)cc1 InChI=1S/C9H12BrNO3SSe/c10-5-7(12)6-16-9-3-1-8(2-4-9)15(11,13)14/h1-4,7,12H,5-6H2,(H2,11,13,14) DWULTEDLARRCDP-UHFFFAOYSA-N 50279711 CHEMBL4174268 Carbonic anhydrase 4 Homo sapiens 319 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279711&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951670 406793939 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988872 CC(C)[C@@H](C[Se]c1ccc(cc1)S(N)(=O)=O)NC(=O)OC(C)(C)C InChI=1S/C16H26N2O4SSe/c1-11(2)14(18-15(19)22-16(3,4)5)10-24-13-8-6-12(7-9-13)23(17,20)21/h6-9,11,14H,10H2,1-5H3,(H,18,19)(H2,17,20,21)/t14-/m1/s1 AJNVGBZBUAPODT-CQSZACIVSA-N 50279706 CHEMBL4165963 Carbonic anhydrase 4 Homo sapiens 2825 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279706&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145953324 406793936 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988875 CC(C)[C@H](N)C[Se]c1ccc(cc1)S(N)(=O)=O InChI=1S/C11H18N2O2SSe/c1-8(2)11(12)7-17-10-5-3-9(4-6-10)16(13,14)15/h3-6,8,11H,7,12H2,1-2H3,(H2,13,14,15)/t11-/m1/s1 CWGQZOZRIOMZFO-LLVKDONJSA-N 50279696 CHEMBL4173889 Carbonic anhydrase 4 Homo sapiens 2321 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279696&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951028 406793932 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988899 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988923 NS(=O)(=O)c1ccc([Se]CC(O)COCc2ccccc2)cc1 InChI=1S/C16H19NO4SSe/c17-22(19,20)15-6-8-16(9-7-15)23-12-14(18)11-21-10-13-4-2-1-3-5-13/h1-9,14,18H,10-12H2,(H2,17,19,20) BVXMBPJDDZCZNW-UHFFFAOYSA-N 50279707 CHEMBL4174548 Carbonic anhydrase 4 Homo sapiens 378 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279707&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949974 406793937 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50988924 Cc1ccc(cc1)S(=O)(=O)N[C@H](C[Se]c1ccc(cc1)S(N)(=O)=O)Cc1ccccc1 InChI=1S/C22H24N2O4S2Se/c1-17-7-9-21(10-8-17)30(27,28)24-19(15-18-5-3-2-4-6-18)16-31-22-13-11-20(12-14-22)29(23,25)26/h2-14,19,24H,15-16H2,1H3,(H2,23,25,26)/t19-/m0/s1 BJTBZMRWPAYZLB-IBGZPJMESA-N 50279708 CHEMBL4170420 Carbonic anhydrase 4 Homo sapiens 5601 ChEMBL 10.1021/acsmedchemlett.7b00387 10.7270/Q22Z182G 29259736 Angeli, A; Tanini, D; Capperucci, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279708&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145954917 406793938 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989324 CN(C)\C=N\c1ncnc2n(CC(=O)Nc3cccc(c3)S(N)(=O)=O)cnc12 InChI=1S/C16H18N8O3S/c1-23(2)9-21-15-14-16(19-8-18-15)24(10-20-14)7-13(25)22-11-4-3-5-12(6-11)28(17,26)27/h3-6,8-10H,7H2,1-2H3,(H,22,25)(H2,17,26,27)/b21-9+ OQPQFDKSUXFQMD-ZVBGSRNCSA-N 50280130 CHEMBL4164589 Carbonic anhydrase 4 Homo sapiens 3838 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280130&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145957582 104121834 ZINC03798580 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989380 NS(=O)(=O)c1cccc(NC(=O)Cn2ccc(=O)[nH]c2=O)c1 InChI=1S/C12H12N4O5S/c13-22(20,21)9-3-1-2-8(6-9)14-11(18)7-16-5-4-10(17)15-12(16)19/h1-6H,7H2,(H,14,18)(H2,13,20,21)(H,15,17,19) XXCVJPSUMCPKTN-UHFFFAOYSA-N 50280249 CHEMBL4171190 Carbonic anhydrase 4 Homo sapiens 2940 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280249&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 34751720 104121953 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989385 CN(C)\C=N\c1ncnc2n(CC(=O)NCc3ccc(cc3)S(N)(=O)=O)cnc12 InChI=1S/C17H20N8O3S/c1-24(2)10-23-16-15-17(21-9-20-16)25(11-22-15)8-14(26)19-7-12-3-5-13(6-4-12)29(18,27)28/h3-6,9-11H,7-8H2,1-2H3,(H,19,26)(H2,18,27,28)/b23-10+ SAUXNZWVZKTLFX-AUEPDCJTSA-N 50280250 CHEMBL4173060 Carbonic anhydrase 4 Homo sapiens 1165 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280250&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949290 104121954 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989393 Nc1ncnc2n(CC(=O)NCCc3ccc(cc3)S(N)(=O)=O)cnc12 InChI=1S/C15H17N7O3S/c16-14-13-15(20-8-19-14)22(9-21-13)7-12(23)18-6-5-10-1-3-11(4-2-10)26(17,24)25/h1-4,8-9H,5-7H2,(H,18,23)(H2,16,19,20)(H2,17,24,25) PUMWMJFQZZVYPO-UHFFFAOYSA-N 50280341 CHEMBL4174004 Carbonic anhydrase 4 Homo sapiens 2247 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280341&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CQS 6B59,6B5A 134812637 104122045 ZINC26254994 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989394 CN(C)\C=N\c1ncnc2n(CC(=O)Nc3ccc(cc3)S(N)(=O)=O)cnc12 InChI=1S/C16H18N8O3S/c1-23(2)9-21-15-14-16(19-8-18-15)24(10-20-14)7-13(25)22-11-3-5-12(6-4-11)28(17,26)27/h3-6,8-10H,7H2,1-2H3,(H,22,25)(H2,17,26,27)/b21-9+ AAPCROHYRKAMCB-ZVBGSRNCSA-N 50280342 CHEMBL4165733 Carbonic anhydrase 4 Homo sapiens 395 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280342&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145955158 104122046 ZINC26184018 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989395 NS(=O)(=O)c1ccc(cc1)-n1cc(Cn2ccc(=O)[nH]c2=O)nn1 InChI=1S/C13H12N6O4S/c14-24(22,23)11-3-1-10(2-4-11)19-8-9(16-17-19)7-18-6-5-12(20)15-13(18)21/h1-6,8H,7H2,(H2,14,22,23)(H,15,20,21) YXJXEAQGRJOQNV-UHFFFAOYSA-N 50280336 CHEMBL4165727 Carbonic anhydrase 4 Homo sapiens 387 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280336&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145954932 104122040 ZINC43598666 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989396 NS(=O)(=O)c1ccc(CNC(=O)Cn2ccc(=O)[nH]c2=O)cc1 InChI=1S/C13H14N4O5S/c14-23(21,22)10-3-1-9(2-4-10)7-15-12(19)8-17-6-5-11(18)16-13(17)20/h1-6H,7-8H2,(H,15,19)(H2,14,21,22)(H,16,18,20) YOLWLZFDBXYATH-UHFFFAOYSA-N 50280335 CHEMBL4163782 Carbonic anhydrase 4 Homo sapiens 1181 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280335&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145957307 104122039 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989476 Nc1ncnc2n(CC(=O)NCc3ccc(cc3)S(N)(=O)=O)cnc12 InChI=1S/C14H15N7O3S/c15-13-12-14(19-7-18-13)21(8-20-12)6-11(22)17-5-9-1-3-10(4-2-9)25(16,23)24/h1-4,7-8H,5-6H2,(H,17,22)(H2,15,18,19)(H2,16,23,24) IUMRIDAXKLGCQO-UHFFFAOYSA-N 50280340 CHEMBL4166080 Carbonic anhydrase 4 Homo sapiens 277 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280340&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145954010 104122044 ZINC36294158 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989477 Nc1ncnc2n(CC(=O)Nc3ccc(cc3)S(N)(=O)=O)cnc12 InChI=1S/C13H13N7O3S/c14-12-11-13(17-6-16-12)20(7-18-11)5-10(21)19-8-1-3-9(4-2-8)24(15,22)23/h1-4,6-7H,5H2,(H,19,21)(H2,14,16,17)(H2,15,22,23) RMDQDEMQEQPCAA-UHFFFAOYSA-N 50280366 CHEMBL4160766 Carbonic anhydrase 4 Homo sapiens 156 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280366&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145957664 104122070 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989478 Nc1ncnc2n(CC(=O)Nc3cccc(c3)S(N)(=O)=O)cnc12 InChI=1S/C13H13N7O3S/c14-12-11-13(17-6-16-12)20(7-18-11)5-10(21)19-8-2-1-3-9(4-8)24(15,22)23/h1-4,6-7H,5H2,(H,19,21)(H2,14,16,17)(H2,15,22,23) SDUJFXHRMDHTFH-UHFFFAOYSA-N 50280365 CHEMBL4171363 Carbonic anhydrase 4 Homo sapiens 3347 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280365&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949615 104122069 ZINC95542886 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989479 Nc1ncnc2n(Cc3cn(nn3)-c3ccc(cc3)S(N)(=O)=O)cnc12 InChI=1S/C14H13N9O2S/c15-13-12-14(18-7-17-13)22(8-19-12)5-9-6-23(21-20-9)10-1-3-11(4-2-10)26(16,24)25/h1-4,6-8H,5H2,(H2,15,17,18)(H2,16,24,25) OGPXNZLLZGSJPE-UHFFFAOYSA-N 50280256 CHEMBL4163797 Carbonic anhydrase 4 Homo sapiens 211 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280256&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145958041 104121960 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989480 Nc1ncnc2n(Cc3cn(nn3)-c3cccc(c3)S(N)(=O)=O)cnc12 InChI=1S/C14H13N9O2S/c15-13-12-14(18-7-17-13)22(8-19-12)5-9-6-23(21-20-9)10-2-1-3-11(4-10)26(16,24)25/h1-4,6-8H,5H2,(H2,15,17,18)(H2,16,24,25) KCPNGIBYIWCOPJ-UHFFFAOYSA-N 50280152 CHEMBL4172009 Carbonic anhydrase 4 Homo sapiens 311 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280152&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951787 104121856 ZINC28755166 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989481 NS(=O)(=O)c1cccc(c1)-n1cc(Cn2ccc(=O)[nH]c2=O)nn1 InChI=1S/C13H12N6O4S/c14-24(22,23)11-3-1-2-10(6-11)19-8-9(16-17-19)7-18-5-4-12(20)15-13(18)21/h1-6,8H,7H2,(H2,14,22,23)(H,15,20,21) GCKHOBJYZJZSLT-UHFFFAOYSA-N 50280345 CHEMBL4173644 Carbonic anhydrase 4 Homo sapiens 300 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280345&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951855 104122049 ZINC26251504 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989482 NS(=O)(=O)c1ccc(O)c(NC(=O)Cn2ccc(=O)[nH]c2=O)c1 InChI=1S/C12H12N4O6S/c13-23(21,22)7-1-2-9(17)8(5-7)14-11(19)6-16-4-3-10(18)15-12(16)20/h1-5,17H,6H2,(H,14,19)(H2,13,21,22)(H,15,18,20) HMAHXFQWQPTYAB-UHFFFAOYSA-N 50280344 CHEMBL4160407 Carbonic anhydrase 4 Homo sapiens 2297 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280344&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145959407 104122048 ZINC26182895 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989483 NS(=O)(=O)c1ccc(CCNC(=O)Cn2ccc(=O)[nH]c2=O)cc1 InChI=1S/C14H16N4O5S/c15-24(22,23)11-3-1-10(2-4-11)5-7-16-13(20)9-18-8-6-12(19)17-14(18)21/h1-4,6,8H,5,7,9H2,(H,16,20)(H2,15,22,23)(H,17,19,21) KGUDYRYHHCBFOD-UHFFFAOYSA-N 50280343 CHEMBL4168320 Carbonic anhydrase 4 Homo sapiens 1780 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280343&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46635132 104122047 ZINC26249664 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989484 NS(=O)(=O)c1ccc(NC(=O)Cn2ccc(=O)[nH]c2=O)cc1 InChI=1S/C12H12N4O5S/c13-22(20,21)9-3-1-8(2-4-9)14-11(18)7-16-6-5-10(17)15-12(16)19/h1-6H,7H2,(H,14,18)(H2,13,20,21)(H,15,17,19) FIFNUJTXJIFDBS-UHFFFAOYSA-N 50280257 CHEMBL4171659 Carbonic anhydrase 4 Homo sapiens 470 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280257&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search QYA 6VJ3 145949437 104121961 ZINC03782249 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989489 Nc1ncnc2n(CCOc3ccc(cc3)S(N)(=O)=O)cnc12 InChI=1S/C13H14N6O3S/c14-12-11-13(17-7-16-12)19(8-18-11)5-6-22-9-1-3-10(4-2-9)23(15,20)21/h1-4,7-8H,5-6H2,(H2,14,16,17)(H2,15,20,21) KXIIKQPJHPLBCN-UHFFFAOYSA-N 50280131 CHEMBL4169103 Carbonic anhydrase 4 Homo sapiens 174 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280131&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145956229 104121835 ZINC28249604 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989490 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50989500 CN(C)\C=N\c1ncnc2n(CC(=O)NCCc3ccc(cc3)S(N)(=O)=O)cnc12 InChI=1S/C18H22N8O3S/c1-25(2)11-24-17-16-18(22-10-21-17)26(12-23-16)9-15(27)20-8-7-13-3-5-14(6-4-13)30(19,28)29/h3-6,10-12H,7-9H2,1-2H3,(H,20,27)(H2,19,28,29)/b24-11+ BRJJFRIYSWVUDW-BHGWPJFGSA-N 50280337 CHEMBL4175889 Carbonic anhydrase 4 Homo sapiens 1974 ChEMBL 10.1021/acsmedchemlett.7b00399 10.7270/Q29P345B 29259754 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280337&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145973355 104122041 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50986788 NS(=O)(=O)c1ccc(cc1)N1CCN=C1c1ccc(Cl)cc1 InChI=1S/C15H14ClN3O2S/c16-12-3-1-11(2-4-12)15-18-9-10-19(15)13-5-7-14(8-6-13)22(17,20)21/h1-8H,9-10H2,(H2,17,20,21) XEDQBNJZQCYXQJ-UHFFFAOYSA-N 50049892 CHEMBL3322410 Carbonic anhydrase 4 Homo sapiens 8142 ChEMBL 10.1021/acsmedchemlett.7b00300 10.7270/Q25141QV 29057059 Kalinin, S; Kopylov, S; Tuccinardi, T; Sapegin, A; Dar'in, D; Angeli, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049892&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 118710108 313069204 CHEMBL3322410 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50986793 NS(=O)(=O)c1ccc(cc1)C1=NCCN1c1cncnc1 InChI=1S/C13H13N5O2S/c14-21(19,20)12-3-1-10(2-4-12)13-17-5-6-18(13)11-7-15-9-16-8-11/h1-4,7-9H,5-6H2,(H2,14,19,20) PSAFEDGVCMAJKK-UHFFFAOYSA-N 50279349 CHEMBL4167060 Carbonic anhydrase 4 Homo sapiens 2296 ChEMBL 10.1021/acsmedchemlett.7b00300 10.7270/Q25141QV 29057059 Kalinin, S; Kopylov, S; Tuccinardi, T; Sapegin, A; Dar'in, D; Angeli, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279349&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145952940 406793725 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50986794 Cc1ccccc1N1CCN=C1c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H17N3O2S/c1-12-4-2-3-5-15(12)19-11-10-18-16(19)13-6-8-14(9-7-13)22(17,20)21/h2-9H,10-11H2,1H3,(H2,17,20,21) TYDGOTHRQPCXRT-UHFFFAOYSA-N 50279362 CHEMBL4173906 Carbonic anhydrase 4 Homo sapiens 961 ChEMBL 10.1021/acsmedchemlett.7b00300 10.7270/Q25141QV 29057059 Kalinin, S; Kopylov, S; Tuccinardi, T; Sapegin, A; Dar'in, D; Angeli, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279362&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951654 406793727 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50986813 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acsmedchemlett.7b00300 10.7270/Q25141QV 29057059 Kalinin, S; Kopylov, S; Tuccinardi, T; Sapegin, A; Dar'in, D; Angeli, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50986814 NS(=O)(=O)c1ccc(cc1)C1=NCCN1c1cccnc1 InChI=1S/C14H14N4O2S/c15-21(19,20)13-5-3-11(4-6-13)14-17-8-9-18(14)12-2-1-7-16-10-12/h1-7,10H,8-9H2,(H2,15,19,20) IGORBCIWJVETIT-UHFFFAOYSA-N 50279357 CHEMBL4174943 Carbonic anhydrase 4 Homo sapiens 1827 ChEMBL 10.1021/acsmedchemlett.7b00300 10.7270/Q25141QV 29057059 Kalinin, S; Kopylov, S; Tuccinardi, T; Sapegin, A; Dar'in, D; Angeli, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279357&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949366 104121296 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50986817 COc1ccc(cc1OC)N1CCN=C1c1ccc(cc1)S(N)(=O)=O InChI=1S/C17H19N3O4S/c1-23-15-8-5-13(11-16(15)24-2)20-10-9-19-17(20)12-3-6-14(7-4-12)25(18,21)22/h3-8,11H,9-10H2,1-2H3,(H2,18,21,22) GSWKZAXHRJILKI-UHFFFAOYSA-N 50279364 CHEMBL4170470 Carbonic anhydrase 4 Homo sapiens 8303 ChEMBL 10.1021/acsmedchemlett.7b00300 10.7270/Q25141QV 29057059 Kalinin, S; Kopylov, S; Tuccinardi, T; Sapegin, A; Dar'in, D; Angeli, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279364&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145955383 406793729 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50986820 CCOc1ccccc1N1CCN=C1c1ccc(cc1)S(N)(=O)=O InChI=1S/C17H19N3O3S/c1-2-23-16-6-4-3-5-15(16)20-12-11-19-17(20)13-7-9-14(10-8-13)24(18,21)22/h3-10H,2,11-12H2,1H3,(H2,18,21,22) LVVOAGXWCMWRSZ-UHFFFAOYSA-N 50279368 CHEMBL4159818 Carbonic anhydrase 4 Homo sapiens 2300 ChEMBL 10.1021/acsmedchemlett.7b00300 10.7270/Q25141QV 29057059 Kalinin, S; Kopylov, S; Tuccinardi, T; Sapegin, A; Dar'in, D; Angeli, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279368&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145959110 104121303 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50986821 COc1ccc(cc1)N1CCN=C1c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H17N3O3S/c1-22-14-6-4-13(5-7-14)19-11-10-18-16(19)12-2-8-15(9-3-12)23(17,20)21/h2-9H,10-11H2,1H3,(H2,17,20,21) XMHBULSHOGYPBM-UHFFFAOYSA-N 50279365 CHEMBL4163192 Carbonic anhydrase 4 Homo sapiens 3643 ChEMBL 10.1021/acsmedchemlett.7b00300 10.7270/Q25141QV 29057059 Kalinin, S; Kopylov, S; Tuccinardi, T; Sapegin, A; Dar'in, D; Angeli, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279365&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145957040 406793730 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50986822 NS(=O)(=O)c1ccc(cc1)C1=NCCN1c1ccc(F)cc1 InChI=1S/C15H14FN3O2S/c16-12-3-5-13(6-4-12)19-10-9-18-15(19)11-1-7-14(8-2-11)22(17,20)21/h1-8H,9-10H2,(H2,17,20,21) DLMDCABCPGECOT-UHFFFAOYSA-N 50279354 CHEMBL4159209 Carbonic anhydrase 4 Homo sapiens 1037 ChEMBL 10.1021/acsmedchemlett.7b00300 10.7270/Q25141QV 29057059 Kalinin, S; Kopylov, S; Tuccinardi, T; Sapegin, A; Dar'in, D; Angeli, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279354&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145956347 406793726 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50986839 NS(=O)(=O)c1ccc(cc1)C1=NCCN1c1ccccc1 InChI=1S/C15H15N3O2S/c16-21(19,20)14-8-6-12(7-9-14)15-17-10-11-18(15)13-4-2-1-3-5-13/h1-9H,10-11H2,(H2,16,19,20) QXGWYHOBBBQCNP-UHFFFAOYSA-N 50279348 CHEMBL4174349 Carbonic anhydrase 4 Homo sapiens 3912 ChEMBL 10.1021/acsmedchemlett.7b00300 10.7270/Q25141QV 29057059 Kalinin, S; Kopylov, S; Tuccinardi, T; Sapegin, A; Dar'in, D; Angeli, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279348&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951463 406793724 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50986842 NS(=O)(=O)c1ccc(cc1)C1=NCCN1c1ccc(Cl)cc1 InChI=1S/C15H14ClN3O2S/c16-12-3-5-13(6-4-12)19-10-9-18-15(19)11-1-7-14(8-2-11)22(17,20)21/h1-8H,9-10H2,(H2,17,20,21) YUNRIGMGNUAEQV-UHFFFAOYSA-N 50279363 CHEMBL4169857 Carbonic anhydrase 4 Homo sapiens 608 ChEMBL 10.1021/acsmedchemlett.7b00300 10.7270/Q25141QV 29057059 Kalinin, S; Kopylov, S; Tuccinardi, T; Sapegin, A; Dar'in, D; Angeli, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279363&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145954185 406793728 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50986848 NS(=O)(=O)c1ccc(cc1)N1CCN=C1c1ccc(F)cc1 InChI=1S/C15H14FN3O2S/c16-12-3-1-11(2-4-12)15-18-9-10-19(15)13-5-7-14(8-6-13)22(17,20)21/h1-8H,9-10H2,(H2,17,20,21) JGUIZDSDTXOOHV-UHFFFAOYSA-N 50049890 CHEMBL3322408 Carbonic anhydrase 4 Homo sapiens 9726 ChEMBL 10.1021/acsmedchemlett.7b00300 10.7270/Q25141QV 29057059 Kalinin, S; Kopylov, S; Tuccinardi, T; Sapegin, A; Dar'in, D; Angeli, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049890&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 118710106 313069202 CHEMBL3322408 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115486 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)NCCOc3ccc(cc3)S(N)(=O)=O)c2c1 InChI=1S/C27H26ClN3O6S/c1-17-23(16-26(32)30-13-14-37-20-7-10-22(11-8-20)38(29,34)35)24-15-21(36-2)9-12-25(24)31(17)27(33)18-3-5-19(28)6-4-18/h3-12,15H,13-14,16H2,1-2H3,(H,30,32)(H2,29,34,35) ULDYARWCYZOHKF-UHFFFAOYSA-N 50456010 CHEMBL4203646 Carbonic anhydrase 4 Homo sapiens 1598 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456010&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145977536 225146926 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115487 CC(C(=O)NCCCCOc1ccc(cc1)S(N)(=O)=O)c1ccc(c(F)c1)-c1ccccc1 InChI=1S/C25H27FN2O4S/c1-18(20-9-14-23(24(26)17-20)19-7-3-2-4-8-19)25(29)28-15-5-6-16-32-21-10-12-22(13-11-21)33(27,30)31/h2-4,7-14,17-18H,5-6,15-16H2,1H3,(H,28,29)(H2,27,30,31) SXZXSKWFAQMQAO-UHFFFAOYSA-N 50456011 CHEMBL4211540 Carbonic anhydrase 4 Homo sapiens 7264 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456011&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145964130 225146927 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115497 NS(=O)(=O)c1ccc(OCCNC(=O)Cc2ccccc2Nc2c(Cl)cccc2Cl)cc1 InChI=1S/C22H21Cl2N3O4S/c23-18-5-3-6-19(24)22(18)27-20-7-2-1-4-15(20)14-21(28)26-12-13-31-16-8-10-17(11-9-16)32(25,29)30/h1-11,27H,12-14H2,(H,26,28)(H2,25,29,30) VNIROKIVWRXGRV-UHFFFAOYSA-N 50456021 CHEMBL4212619 Carbonic anhydrase 4 Homo sapiens 5483 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456021&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145964400 225146937 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115545 CC(C)Cc1ccc(cc1)C(C)C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C19H24N2O3S/c1-13(2)12-15-4-6-16(7-5-15)14(3)19(22)21-17-8-10-18(11-9-17)25(20,23)24/h4-11,13-14H,12H2,1-3H3,(H,21,22)(H2,20,23,24) NOBISVURYNCXLY-UHFFFAOYSA-N 50456052 CHEMBL4203442 Carbonic anhydrase 4 Homo sapiens 218 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456052&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 14498136 225146968 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115546 NS(=O)(=O)c1ccc(NC(=O)C2CCn3c2ccc3C(=O)c2ccccc2)cc1 InChI=1S/C21H19N3O4S/c22-29(27,28)16-8-6-15(7-9-16)23-21(26)17-12-13-24-18(17)10-11-19(24)20(25)14-4-2-1-3-5-14/h1-11,17H,12-13H2,(H,23,26)(H2,22,27,28) PMIJIUBQPGGGSW-UHFFFAOYSA-N 50456056 CHEMBL4209195 Carbonic anhydrase 4 Homo sapiens 1495 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456056&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46861342 225146972 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115547 C[S+]([O-])c1ccc(\C=C2/C(C)=C(CC(=O)Nc3ccc(cc3)S(N)(=O)=O)c3cc(F)ccc23)cc1 InChI=1S/C26H23FN2O4S2/c1-16-23(13-17-3-8-20(9-4-17)34(2)31)22-12-5-18(27)14-25(22)24(16)15-26(30)29-19-6-10-21(11-7-19)35(28,32)33/h3-14H,15H2,1-2H3,(H,29,30)(H2,28,32,33)/b23-13+ GLJNTGMICWRYRF-YDZHTSKRSA-N 50456032 CHEMBL4204331 Carbonic anhydrase 4 Homo sapiens 519 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456032&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145977814 225146948 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115548 NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2Nc2c(Cl)cccc2Cl)cc1 InChI=1S/C20H17Cl2N3O3S/c21-16-5-3-6-17(22)20(16)25-18-7-2-1-4-13(18)12-19(26)24-14-8-10-15(11-9-14)29(23,27)28/h1-11,25H,12H2,(H,24,26)(H2,23,27,28) TZWKNAVYTUOLLG-UHFFFAOYSA-N 50456012 CHEMBL4208656 Carbonic anhydrase 4 Homo sapiens 179 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456012&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 24286289 225146928 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115549 CC(C)Cc1ccc(cc1)C(C)C(=O)NCCc1ccc(cc1)S(N)(=O)=O InChI=1S/C21H28N2O3S/c1-15(2)14-18-4-8-19(9-5-18)16(3)21(24)23-13-12-17-6-10-20(11-7-17)27(22,25)26/h4-11,15-16H,12-14H2,1-3H3,(H,23,24)(H2,22,25,26) CECPPOZAELTWDI-UHFFFAOYSA-N 50456036 CHEMBL4207066 Carbonic anhydrase 4 Homo sapiens 7298 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456036&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145975933 225146952 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115550 COc1ccc2cc(ccc2c1)C(C)C(=O)NCCc1ccc(cc1)S(N)(=O)=O InChI=1S/C22H24N2O4S/c1-15(17-5-6-19-14-20(28-2)8-7-18(19)13-17)22(25)24-12-11-16-3-9-21(10-4-16)29(23,26)27/h3-10,13-15H,11-12H2,1-2H3,(H,24,25)(H2,23,26,27) VNUYSUSGHSAXEW-UHFFFAOYSA-N 50456015 CHEMBL4216600 Carbonic anhydrase 4 Homo sapiens 6028 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456015&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10136406 225146931 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115551 C[S+]([O-])c1ccc(\C=C2/C(C)=C(CC(=O)NCCc3ccc(cc3)S(N)(=O)=O)c3cc(F)ccc23)cc1 InChI=1S/C28H27FN2O4S2/c1-18-25(15-20-3-8-22(9-4-20)36(2)33)24-12-7-21(29)16-27(24)26(18)17-28(32)31-14-13-19-5-10-23(11-6-19)37(30,34)35/h3-12,15-16H,13-14,17H2,1-2H3,(H,31,32)(H2,30,34,35)/b25-15+ HUTIYVVTBLDZMG-MFKUBSTISA-N 50456045 CHEMBL4217005 Carbonic anhydrase 4 Homo sapiens 6857 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456045&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145974710 225146961 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115552 CC(C)Cc1ccc(cc1)C(C)C(=O)NCCOc1ccc(cc1)S(N)(=O)=O InChI=1S/C21H28N2O4S/c1-15(2)14-17-4-6-18(7-5-17)16(3)21(24)23-12-13-27-19-8-10-20(11-9-19)28(22,25)26/h4-11,15-16H,12-14H2,1-3H3,(H,23,24)(H2,22,25,26) AKUASIWSLQWUSP-UHFFFAOYSA-N 50456047 CHEMBL4211024 Carbonic anhydrase 4 Homo sapiens 60 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456047&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145964340 225146963 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115553 COc1ccc2cc(ccc2c1)C(C)C(=O)NCCOc1ccc(cc1)S(N)(=O)=O InChI=1S/C22H24N2O5S/c1-15(16-3-4-18-14-20(28-2)6-5-17(18)13-16)22(25)24-11-12-29-19-7-9-21(10-8-19)30(23,26)27/h3-10,13-15H,11-12H2,1-2H3,(H,24,25)(H2,23,26,27) PXTIXWMAPRZGGO-UHFFFAOYSA-N 50456057 CHEMBL4218254 Carbonic anhydrase 4 Homo sapiens 73 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456057&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145968701 225146973 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115554 CC(C(=O)NCCOc1ccc(cc1)S(N)(=O)=O)c1cccc(c1)C(=O)c1ccccc1 InChI=1S/C24H24N2O5S/c1-17(19-8-5-9-20(16-19)23(27)18-6-3-2-4-7-18)24(28)26-14-15-31-21-10-12-22(13-11-21)32(25,29)30/h2-13,16-17H,14-15H2,1H3,(H,26,28)(H2,25,29,30) GLOHXCOOYDYKOF-UHFFFAOYSA-N 50456017 CHEMBL4203780 Carbonic anhydrase 4 Homo sapiens 78 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456017&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145975077 225146933 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115555 C[S+]([O-])c1ccc(\C=C2/C(C)=C(CC(=O)NCCOc3ccc(cc3)S(N)(=O)=O)c3cc(F)ccc23)cc1 InChI=1S/C28H27FN2O5S2/c1-18-25(15-19-3-8-22(9-4-19)37(2)33)24-12-5-20(29)16-27(24)26(18)17-28(32)31-13-14-36-21-6-10-23(11-7-21)38(30,34)35/h3-12,15-16H,13-14,17H2,1-2H3,(H,31,32)(H2,30,34,35)/b25-15+ SKOXNUJTXFITBK-MFKUBSTISA-N 50456054 CHEMBL4215319 Carbonic anhydrase 4 Homo sapiens 5996 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456054&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145973465 225146970 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115556 CC(C)Cc1ccc(cc1)C(C)C(=O)NCCCOc1ccc(cc1)S(N)(=O)=O InChI=1S/C22H30N2O4S/c1-16(2)15-18-5-7-19(8-6-18)17(3)22(25)24-13-4-14-28-20-9-11-21(12-10-20)29(23,26)27/h5-12,16-17H,4,13-15H2,1-3H3,(H,24,25)(H2,23,26,27) UBWFOFQYWMLOHJ-UHFFFAOYSA-N 50456019 CHEMBL4212490 Carbonic anhydrase 4 Homo sapiens 64 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456019&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145966475 225146935 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115557 CC(C(=O)NCCCOc1ccc(cc1)S(N)(=O)=O)c1ccc(c(F)c1)-c1ccccc1 InChI=1S/C24H25FN2O4S/c1-17(19-8-13-22(23(25)16-19)18-6-3-2-4-7-18)24(28)27-14-5-15-31-20-9-11-21(12-10-20)32(26,29)30/h2-4,6-13,16-17H,5,14-15H2,1H3,(H,27,28)(H2,26,29,30) YKEULJQRBHWKDW-UHFFFAOYSA-N 50456058 CHEMBL4215466 Carbonic anhydrase 4 Homo sapiens 301 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456058&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145972316 225146974 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115558 NS(=O)(=O)c1ccc(OCCCNC(=O)C2CCn3c2ccc3C(=O)c2ccccc2)cc1 InChI=1S/C24H25N3O5S/c25-33(30,31)19-9-7-18(8-10-19)32-16-4-14-26-24(29)20-13-15-27-21(20)11-12-22(27)23(28)17-5-2-1-3-6-17/h1-3,5-12,20H,4,13-16H2,(H,26,29)(H2,25,30,31) KMALCYBDCXVPKG-UHFFFAOYSA-N 50456026 CHEMBL4218080 Carbonic anhydrase 4 Homo sapiens 296 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456026&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145969379 225146942 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115559 C[S+]([O-])c1ccc(\C=C2/C(C)=C(CC(=O)NCCCOc3ccc(cc3)S(N)(=O)=O)c3cc(F)ccc23)cc1 InChI=1S/C29H29FN2O5S2/c1-19-26(16-20-4-9-23(10-5-20)38(2)34)25-13-6-21(30)17-28(25)27(19)18-29(33)32-14-3-15-37-22-7-11-24(12-8-22)39(31,35)36/h4-13,16-17H,3,14-15,18H2,1-2H3,(H,32,33)(H2,31,35,36)/b26-16+ ZJFXKNSRBFMHAO-WGOQTCKBSA-N 50456049 CHEMBL4208573 Carbonic anhydrase 4 Homo sapiens 811 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456049&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145966558 225146965 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115560 NS(=O)(=O)c1ccc(OCCCNC(=O)Cc2ccccc2Nc2c(Cl)cccc2Cl)cc1 InChI=1S/C23H23Cl2N3O4S/c24-19-6-3-7-20(25)23(19)28-21-8-2-1-5-16(21)15-22(29)27-13-4-14-32-17-9-11-18(12-10-17)33(26,30)31/h1-3,5-12,28H,4,13-15H2,(H,27,29)(H2,26,30,31) VRBIGEFOPTXOQN-UHFFFAOYSA-N 50456018 CHEMBL4208676 Carbonic anhydrase 4 Homo sapiens 673 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456018&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145967040 225146934 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115561 CC(C)Cc1ccc(cc1)C(C)C(=O)NCCCCOc1ccc(cc1)S(N)(=O)=O InChI=1S/C23H32N2O4S/c1-17(2)16-19-6-8-20(9-7-19)18(3)23(26)25-14-4-5-15-29-21-10-12-22(13-11-21)30(24,27)28/h6-13,17-18H,4-5,14-16H2,1-3H3,(H,25,26)(H2,24,27,28) LELPHLASVPCEJD-UHFFFAOYSA-N 50456055 CHEMBL4202789 Carbonic anhydrase 4 Homo sapiens 2804 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456055&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145978673 225146971 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115562 CC(C(=O)NCCCCOc1ccc(cc1)S(N)(=O)=O)c1cccc(c1)C(=O)c1ccccc1 InChI=1S/C26H28N2O5S/c1-19(21-10-7-11-22(18-21)25(29)20-8-3-2-4-9-20)26(30)28-16-5-6-17-33-23-12-14-24(15-13-23)34(27,31)32/h2-4,7-15,18-19H,5-6,16-17H2,1H3,(H,28,30)(H2,27,31,32) WCTKEYVDQAIYKK-UHFFFAOYSA-N 50456014 CHEMBL4211029 Carbonic anhydrase 4 Homo sapiens 93 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456014&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145964558 225146930 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115563 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)NCCCCOc3ccc(cc3)S(N)(=O)=O)c2c1 InChI=1S/C29H30ClN3O6S/c1-19-25(18-28(34)32-15-3-4-16-39-22-9-12-24(13-10-22)40(31,36)37)26-17-23(38-2)11-14-27(26)33(19)29(35)20-5-7-21(30)8-6-20/h5-14,17H,3-4,15-16,18H2,1-2H3,(H,32,34)(H2,31,36,37) OWXCNNFFXOOPBZ-UHFFFAOYSA-N 50456051 CHEMBL4214565 Carbonic anhydrase 4 Homo sapiens 8136 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456051&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145972986 225146967 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115564 NS(=O)(=O)c1ccc(OCCCCNC(=O)Cc2ccccc2Nc2c(Cl)cccc2Cl)cc1 InChI=1S/C24H25Cl2N3O4S/c25-20-7-5-8-21(26)24(20)29-22-9-2-1-6-17(22)16-23(30)28-14-3-4-15-33-18-10-12-19(13-11-18)34(27,31)32/h1-2,5-13,29H,3-4,14-16H2,(H,28,30)(H2,27,31,32) FLXNYPCDBXLLFW-UHFFFAOYSA-N 50456016 CHEMBL4218332 Carbonic anhydrase 4 Homo sapiens 8023 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456016&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145968242 225146932 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115581 CC(C(=O)Nc1ccc(cc1)S(N)(=O)=O)c1ccc(c(F)c1)-c1ccccc1 InChI=1S/C21H19FN2O3S/c1-14(21(25)24-17-8-10-18(11-9-17)28(23,26)27)16-7-12-19(20(22)13-16)15-5-3-2-4-6-15/h2-14H,1H3,(H,24,25)(H2,23,26,27) GDICZDBXVAHLCC-UHFFFAOYSA-N 50456034 CHEMBL4216521 Carbonic anhydrase 4 Homo sapiens 718 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456034&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 72695827 225146950 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115587 CC(C(=O)NCCc1ccc(cc1)S(N)(=O)=O)c1cccc(c1)C(=O)c1ccccc1 InChI=1S/C24H24N2O4S/c1-17(20-8-5-9-21(16-20)23(27)19-6-3-2-4-7-19)24(28)26-15-14-18-10-12-22(13-11-18)31(25,29)30/h2-13,16-17H,14-15H2,1H3,(H,26,28)(H2,25,29,30) LDTAVMCTXBDUEN-UHFFFAOYSA-N 50456059 CHEMBL4207132 Carbonic anhydrase 4 Homo sapiens 3005 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456059&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145978605 225146975 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115619 COc1ccc2cc(ccc2c1)C(C)C(=O)NCCCCOc1ccc(cc1)S(N)(=O)=O InChI=1S/C24H28N2O5S/c1-17(18-5-6-20-16-22(30-2)8-7-19(20)15-18)24(27)26-13-3-4-14-31-21-9-11-23(12-10-21)32(25,28)29/h5-12,15-17H,3-4,13-14H2,1-2H3,(H,26,27)(H2,25,28,29) IKGAHAWLHSVRCL-UHFFFAOYSA-N 50456050 CHEMBL4215990 Carbonic anhydrase 4 Homo sapiens 2693 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456050&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145972104 225146966 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115624 NS(=O)(=O)c1ccc(CCNC(=O)C2CCn3c2ccc3C(=O)c2ccccc2)cc1 InChI=1S/C23H23N3O4S/c24-31(29,30)18-8-6-16(7-9-18)12-14-25-23(28)19-13-15-26-20(19)10-11-21(26)22(27)17-4-2-1-3-5-17/h1-11,19H,12-15H2,(H,25,28)(H2,24,29,30) UYMJAVPMWBAECG-UHFFFAOYSA-N 50456037 CHEMBL4202541 Carbonic anhydrase 4 Homo sapiens 3877 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456037&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145976735 225146953 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115632 CC(C(=O)Nc1ccc(cc1)S(N)(=O)=O)c1cccc(c1)C(=O)c1ccccc1 InChI=1S/C22H20N2O4S/c1-15(22(26)24-19-10-12-20(13-11-19)29(23,27)28)17-8-5-9-18(14-17)21(25)16-6-3-2-4-7-16/h2-15H,1H3,(H,24,26)(H2,23,27,28) MLGDEBKBOJCREB-UHFFFAOYSA-N 50456024 CHEMBL4217367 Carbonic anhydrase 4 Homo sapiens 49 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456024&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145972397 225146940 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115634 NS(=O)(=O)c1ccc(CCNC(=O)Cc2ccccc2Nc2c(Cl)cccc2Cl)cc1 InChI=1S/C22H21Cl2N3O3S/c23-18-5-3-6-19(24)22(18)27-20-7-2-1-4-16(20)14-21(28)26-13-12-15-8-10-17(11-9-15)31(25,29)30/h1-11,27H,12-14H2,(H,26,28)(H2,25,29,30) CDVPARPTSXWSQA-UHFFFAOYSA-N 50456053 CHEMBL4205682 Carbonic anhydrase 4 Homo sapiens 8654 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456053&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145975151 225146969 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115635 CC(C(=O)NCCOc1ccc(cc1)S(N)(=O)=O)c1ccc(c(F)c1)-c1ccccc1 InChI=1S/C23H23FN2O4S/c1-16(18-7-12-21(22(24)15-18)17-5-3-2-4-6-17)23(27)26-13-14-30-19-8-10-20(11-9-19)31(25,28)29/h2-12,15-16H,13-14H2,1H3,(H,26,27)(H2,25,28,29) ZALRHFHOXJTXDE-UHFFFAOYSA-N 50456013 CHEMBL4208492 Carbonic anhydrase 4 Homo sapiens 355 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456013&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145967030 225146929 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115636 CC(C(=O)NCCCOc1ccc(cc1)S(N)(=O)=O)c1cccc(c1)C(=O)c1ccccc1 InChI=1S/C25H26N2O5S/c1-18(20-9-5-10-21(17-20)24(28)19-7-3-2-4-8-19)25(29)27-15-6-16-32-22-11-13-23(14-12-22)33(26,30)31/h2-5,7-14,17-18H,6,15-16H2,1H3,(H,27,29)(H2,26,30,31) LCMKFYRXIFBJTQ-UHFFFAOYSA-N 50456060 CHEMBL4215519 Carbonic anhydrase 4 Homo sapiens 77 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456060&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145974401 225146976 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115637 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)NCCCOc3ccc(cc3)S(N)(=O)=O)c2c1 InChI=1S/C28H28ClN3O6S/c1-18-24(17-27(33)31-14-3-15-38-21-8-11-23(12-9-21)39(30,35)36)25-16-22(37-2)10-13-26(25)32(18)28(34)19-4-6-20(29)7-5-19/h4-13,16H,3,14-15,17H2,1-2H3,(H,31,33)(H2,30,35,36) URSSZOMTJAECIW-UHFFFAOYSA-N 50456061 CHEMBL4204047 Carbonic anhydrase 4 Homo sapiens 523 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456061&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145978025 225146977 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115638 C[S+]([O-])c1ccc(\C=C2/C(C)=C(CC(=O)NCCCCOc3ccc(cc3)S(N)(=O)=O)c3cc(F)ccc23)cc1 InChI=1S/C30H31FN2O5S2/c1-20-27(17-21-5-10-24(11-6-21)39(2)35)26-14-7-22(31)18-29(26)28(20)19-30(34)33-15-3-4-16-38-23-8-12-25(13-9-23)40(32,36)37/h5-14,17-18H,3-4,15-16,19H2,1-2H3,(H,33,34)(H2,32,36,37)/b27-17+ BEMLJBASQWGZER-WPWMEQJKSA-N 50456025 CHEMBL4206656 Carbonic anhydrase 4 Homo sapiens 7737 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456025&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145975424 225146941 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115639 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117749 NS(=O)(=O)c1cccc(c1)\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(Br)cc12 InChI=1S/C17H11BrN4O4S2/c18-8-4-5-12-11(6-8)13(15(23)21-12)14-16(24)22-17(27-14)20-9-2-1-3-10(7-9)28(19,25)26/h1-7H,(H,21,23)(H2,19,25,26)(H,20,22,24)/b14-13- GVANVBQPWRGWKR-YPKPFQOOSA-N 50456992 CHEMBL4214360 Carbonic anhydrase 4 Homo sapiens 235 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456992&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145971793 433924259 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117755 NS(=O)(=O)c1ccc(cc1)\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(F)cc12 InChI=1S/C17H11FN4O4S2/c18-8-1-6-12-11(7-8)13(15(23)21-12)14-16(24)22-17(27-14)20-9-2-4-10(5-3-9)28(19,25)26/h1-7H,(H,21,23)(H2,19,25,26)(H,20,22,24)/b14-13- BVTPAAHGCSCLAH-YPKPFQOOSA-N 50456997 CHEMBL4213947 Carbonic anhydrase 4 Homo sapiens 4291 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456997&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145965133 433924264 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117756 NS(=O)(=O)c1cccc(c1)\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(cc12)[N+]([O-])=O InChI=1S/C17H11N5O6S2/c18-30(27,28)10-3-1-2-8(6-10)19-17-21-16(24)14(29-17)13-11-7-9(22(25)26)4-5-12(11)20-15(13)23/h1-7H,(H,20,23)(H2,18,27,28)(H,19,21,24)/b14-13- UASJJMJCPSGEMY-YPKPFQOOSA-N 50456998 CHEMBL4203287 Carbonic anhydrase 4 Homo sapiens 442 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456998&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145978690 433924265 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112305 NS(=O)(=O)c1cc(C(=O)Nn2cnc3ccccc23)c(Cl)cc1Cl InChI=1S/C14H10Cl2N4O3S/c15-9-6-10(16)13(24(17,22)23)5-8(9)14(21)19-20-7-18-11-3-1-2-4-12(11)20/h1-7H,(H,19,21)(H2,17,22,23) AKBIFIJQRGIDLH-UHFFFAOYSA-N 50454308 CHEMBL4207577 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454308&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 138377179 433922667 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112306 NS(=O)(=O)c1cc(ccc1Cl)C(=O)Cn1cnc2ccccc12 InChI=1S/C15H12ClN3O3S/c16-11-6-5-10(7-15(11)23(17,21)22)14(20)8-19-9-18-12-3-1-2-4-13(12)19/h1-7,9H,8H2,(H2,17,21,22) XXDZSNJTAQNIAQ-UHFFFAOYSA-N 50329832 5-(1H-Benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide::CHEMBL1272187::N-alkylated benzimidazole derivative, 4a::carbonic anhydrase (CA) inhibitors, benzenesulphonamide ligand, 4 Carbonic anhydrase 4 Homo sapiens 3.1 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329832&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search E02 3M98 50904886 123108947 CHEMBL1272187 ZINC64526986 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115668 COc1ccc2cc(ccc2c1)C(C)C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C20H20N2O4S/c1-13(14-3-4-16-12-18(26-2)8-5-15(16)11-14)20(23)22-17-6-9-19(10-7-17)27(21,24)25/h3-13H,1-2H3,(H,22,23)(H2,21,24,25) AMYIARUUMISUFR-UHFFFAOYSA-N 50456033 CHEMBL4214085 Carbonic anhydrase 4 Homo sapiens 653 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456033&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 54612935 225146949 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115669 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)Nc3ccc(cc3)S(N)(=O)=O)c2c1 InChI=1S/C25H22ClN3O5S/c1-15-21(14-24(30)28-18-7-10-20(11-8-18)35(27,32)33)22-13-19(34-2)9-12-23(22)29(15)25(31)16-3-5-17(26)6-4-16/h3-13H,14H2,1-2H3,(H,28,30)(H2,27,32,33) RSAJRPQZDKCHJB-UHFFFAOYSA-N 50456035 CHEMBL4206567 Carbonic anhydrase 4 Homo sapiens 4375 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456035&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129883275 225146951 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115670 CC(C(=O)NCCc1ccc(cc1)S(N)(=O)=O)c1ccc(c(F)c1)-c1ccccc1 InChI=1S/C23H23FN2O3S/c1-16(19-9-12-21(22(24)15-19)18-5-3-2-4-6-18)23(27)26-14-13-17-7-10-20(11-8-17)30(25,28)29/h2-12,15-16H,13-14H2,1H3,(H,26,27)(H2,25,28,29) FUJASGVQPVMSEU-UHFFFAOYSA-N 50456022 CHEMBL4203913 Carbonic anhydrase 4 Homo sapiens 3053 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456022&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145976539 225146938 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115671 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)NCCc3ccc(cc3)S(N)(=O)=O)c2c1 InChI=1S/C27H26ClN3O5S/c1-17-23(16-26(32)30-14-13-18-3-10-22(11-4-18)37(29,34)35)24-15-21(36-2)9-12-25(24)31(17)27(33)19-5-7-20(28)8-6-19/h3-12,15H,13-14,16H2,1-2H3,(H,30,32)(H2,29,34,35) YRQDFZQOZOMMRB-UHFFFAOYSA-N 50456046 CHEMBL4215805 Carbonic anhydrase 4 Homo sapiens 8365 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456046&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4857564 225146962 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51115672 COc1ccc2cc(ccc2c1)C(C)C(=O)NCCCOc1ccc(cc1)S(N)(=O)=O InChI=1S/C23H26N2O5S/c1-16(17-4-5-19-15-21(29-2)7-6-18(19)14-17)23(26)25-12-3-13-30-20-8-10-22(11-9-20)31(24,27)28/h4-11,14-16H,3,12-13H2,1-2H3,(H,25,26)(H2,24,27,28) IHKYZJVXRBQNME-UHFFFAOYSA-N 50456048 CHEMBL4205762 Carbonic anhydrase 4 Homo sapiens 220 ChEMBL 10.1021/acs.jmedchem.8b00420 10.7270/Q2F192BQ 29746127 Akgul, O; Di Cesare Mannelli, L; Vullo, D; Angeli, A; Ghelardini, C; Bartolucci, G; Alfawaz Altamimi, AS; Scozzafava, A; Supuran, CT; Carta, F Ege University Bornova http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456048&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145978780 225146964 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117781 NS(=O)(=O)c1ccc(cc1)\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccccc12 InChI=1S/C17H12N4O4S2/c18-27(24,25)10-7-5-9(6-8-10)19-17-21-16(23)14(26-17)13-11-3-1-2-4-12(11)20-15(13)22/h1-8H,(H,20,22)(H2,18,24,25)(H,19,21,23)/b14-13- QMJXAJVVIKYUSC-YPKPFQOOSA-N 50457004 CHEMBL4217700 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457004&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145974266 433924271 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117782 NS(=O)(=O)c1ccc(cc1)\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(Cl)cc12 InChI=1S/C17H11ClN4O4S2/c18-8-1-6-12-11(7-8)13(15(23)21-12)14-16(24)22-17(27-14)20-9-2-4-10(5-3-9)28(19,25)26/h1-7H,(H,21,23)(H2,19,25,26)(H,20,22,24)/b14-13- LMASTTSQUHZWAS-YPKPFQOOSA-N 50456986 CHEMBL4208858 Carbonic anhydrase 4 Homo sapiens 3256 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456986&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145967049 433924253 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117783 Cc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3ccc(cc3)S(N)(=O)=O)c2c1 InChI=1S/C18H14N4O4S2/c1-9-2-7-13-12(8-9)14(16(23)21-13)15-17(24)22-18(27-15)20-10-3-5-11(6-4-10)28(19,25)26/h2-8H,1H3,(H,21,23)(H2,19,25,26)(H,20,22,24)/b15-14- WBFWASSTCOJLCZ-PFONDFGASA-N 50457001 CHEMBL4209398 Carbonic anhydrase 4 Homo sapiens 2864 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457001&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145967308 433924268 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117784 NS(=O)(=O)c1ccc(cc1)\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(cc12)[N+]([O-])=O InChI=1S/C17H11N5O6S2/c18-30(27,28)10-4-1-8(2-5-10)19-17-21-16(24)14(29-17)13-11-7-9(22(25)26)3-6-12(11)20-15(13)23/h1-7H,(H,20,23)(H2,18,27,28)(H,19,21,24)/b14-13- CZSBJNYZZFMGGZ-YPKPFQOOSA-N 50456990 CHEMBL4216703 Carbonic anhydrase 4 Homo sapiens 3682 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456990&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145972603 433924257 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117785 NS(=O)(=O)c1cccc(c1)\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccccc12 InChI=1S/C17H12N4O4S2/c18-27(24,25)10-5-3-4-9(8-10)19-17-21-16(23)14(26-17)13-11-6-1-2-7-12(11)20-15(13)22/h1-8H,(H,20,22)(H2,18,24,25)(H,19,21,23)/b14-13- GPVQCLNAYXPBGF-YPKPFQOOSA-N 50456988 CHEMBL4206714 Carbonic anhydrase 4 Homo sapiens 1973 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456988&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145977904 433924255 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117786 NS(=O)(=O)c1cccc(c1)\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(Cl)cc12 InChI=1S/C17H11ClN4O4S2/c18-8-4-5-12-11(6-8)13(15(23)21-12)14-16(24)22-17(27-14)20-9-2-1-3-10(7-9)28(19,25)26/h1-7H,(H,21,23)(H2,19,25,26)(H,20,22,24)/b14-13- PYKPHKUGZMULMO-YPKPFQOOSA-N 50456999 CHEMBL4203013 Carbonic anhydrase 4 Homo sapiens 396 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456999&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145975281 433924266 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117787 CN1C(=O)\C(=C2/S\C(NC2=O)=N\c2ccc(cc2)S(N)(=O)=O)c2ccccc12 InChI=1S/C18H14N4O4S2/c1-22-13-5-3-2-4-12(13)14(17(22)24)15-16(23)21-18(27-15)20-10-6-8-11(9-7-10)28(19,25)26/h2-9H,1H3,(H2,19,25,26)(H,20,21,23)/b15-14- AWIHYDJNJUXLBA-PFONDFGASA-N 50456996 CHEMBL4216620 Carbonic anhydrase 4 Homo sapiens 4712 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456996&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145972366 433924263 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117788 CN1C(=O)\C(=C2/S\C(NC2=O)=N\c2ccc(cc2)S(N)(=O)=O)c2cc(Br)ccc12 InChI=1S/C18H13BrN4O4S2/c1-23-13-7-2-9(19)8-12(13)14(17(23)25)15-16(24)22-18(28-15)21-10-3-5-11(6-4-10)29(20,26)27/h2-8H,1H3,(H2,20,26,27)(H,21,22,24)/b15-14- RPJQBXZFLFBAKN-PFONDFGASA-N 50456995 CHEMBL4206779 Carbonic anhydrase 4 Homo sapiens 2634 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456995&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145976658 433924262 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117789 NS(=O)(=O)c1ccc(cc1)\N=C1/NC(=O)\C(S1)=C1\C(=O)N(Cc2ccccc2)c2ccccc12 InChI=1S/C24H18N4O4S2/c25-34(31,32)17-12-10-16(11-13-17)26-24-27-22(29)21(33-24)20-18-8-4-5-9-19(18)28(23(20)30)14-15-6-2-1-3-7-15/h1-13H,14H2,(H2,25,31,32)(H,26,27,29)/b21-20- BRLCVKYPAQNQIC-MRCUWXFGSA-N 50456987 CHEMBL4216120 Carbonic anhydrase 4 Homo sapiens 3300 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456987&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145973952 433924254 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117790 NS(=O)(=O)c1ccc(cc1)\N=C1/NC(=O)\C(S1)=C1\C(=O)N(Cc2ccccc2)c2ccc(Br)cc12 InChI=1S/C24H17BrN4O4S2/c25-15-6-11-19-18(12-15)20(23(31)29(19)13-14-4-2-1-3-5-14)21-22(30)28-24(34-21)27-16-7-9-17(10-8-16)35(26,32)33/h1-12H,13H2,(H2,26,32,33)(H,27,28,30)/b21-20- ZSQGYEQCPHGMKH-MRCUWXFGSA-N 50457007 CHEMBL4216972 Carbonic anhydrase 4 Homo sapiens 2897 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457007&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145973308 433924274 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117791 NS(=O)(=O)c1ccc(NC2=NC(=O)CS2)cc1 InChI=1S/C9H9N3O3S2/c10-17(14,15)7-3-1-6(2-4-7)11-9-12-8(13)5-16-9/h1-4H,5H2,(H2,10,14,15)(H,11,12,13) RWMDQWYQDKEGBG-UHFFFAOYSA-N 50456991 CHEMBL2237247 Carbonic anhydrase 4 Homo sapiens 348 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456991&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 135422576 433924258 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117792 NS(=O)(=O)c1cccc(c1)\N=C1/NC(=O)CS1 InChI=1S/C9H9N3O3S2/c10-17(14,15)7-3-1-2-6(4-7)11-9-12-8(13)5-16-9/h1-4H,5H2,(H2,10,14,15)(H,11,12,13) FSBPYABJZSGATG-UHFFFAOYSA-N 50457003 CHEMBL4207124 Carbonic anhydrase 4 Homo sapiens 102 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457003&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145978140 433924270 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117806 NS(=O)(=O)c1ccc(cc1)\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(Br)cc12 InChI=1S/C17H11BrN4O4S2/c18-8-1-6-12-11(7-8)13(15(23)21-12)14-16(24)22-17(27-14)20-9-2-4-10(5-3-9)28(19,25)26/h1-7H,(H,21,23)(H2,19,25,26)(H,20,22,24)/b14-13- SJBBKDUMZRKKBW-YPKPFQOOSA-N 50457000 CHEMBL4215469 Carbonic anhydrase 4 Homo sapiens 2986 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457000&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145972551 433924267 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117807 COc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(c3)S(N)(=O)=O)c2c1 InChI=1S/C18H14N4O5S2/c1-27-10-5-6-13-12(8-10)14(16(23)21-13)15-17(24)22-18(28-15)20-9-3-2-4-11(7-9)29(19,25)26/h2-8H,1H3,(H,21,23)(H2,19,25,26)(H,20,22,24)/b15-14- CIKCPALEUQTPMO-PFONDFGASA-N 50457005 CHEMBL4215023 Carbonic anhydrase 4 Homo sapiens 2527 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457005&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145973004 433924272 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117808 NS(=O)(=O)c1cccc(c1)\N=C1/NC(=O)\C(S1)=C1\C(=O)N(Cc2ccccc2)c2ccccc12 InChI=1S/C24H18N4O4S2/c25-34(31,32)17-10-6-9-16(13-17)26-24-27-22(29)21(33-24)20-18-11-4-5-12-19(18)28(23(20)30)14-15-7-2-1-3-8-15/h1-13H,14H2,(H2,25,31,32)(H,26,27,29)/b21-20- YHOPAXPQWMGSQU-MRCUWXFGSA-N 50456993 CHEMBL4209378 Carbonic anhydrase 4 Homo sapiens 2245 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456993&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145966343 433924260 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117816 COc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3ccc(cc3)S(N)(=O)=O)c2c1 InChI=1S/C18H14N4O5S2/c1-27-10-4-7-13-12(8-10)14(16(23)21-13)15-17(24)22-18(28-15)20-9-2-5-11(6-3-9)29(19,25)26/h2-8H,1H3,(H,21,23)(H2,19,25,26)(H,20,22,24)/b15-14- HPTUQPXTGAFEMJ-PFONDFGASA-N 50456994 CHEMBL4204520 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456994&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145977574 433924261 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117817 Cc1cc2\C(C(=O)Nc2c(C)c1)=C1\S\C(NC1=O)=N\c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H16N4O4S2/c1-9-7-10(2)15-13(8-9)14(17(24)22-15)16-18(25)23-19(28-16)21-11-3-5-12(6-4-11)29(20,26)27/h3-8H,1-2H3,(H,22,24)(H2,20,26,27)(H,21,23,25)/b16-14- AYBVMMLSCDNMDZ-PEZBUJJGSA-N 50457002 CHEMBL4205019 Carbonic anhydrase 4 Homo sapiens 4751 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457002&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145975355 433924269 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117818 CN1C(=O)\C(=C2/S\C(NC2=O)=N\c2ccc(cc2)S(N)(=O)=O)c2cc(Cl)ccc12 InChI=1S/C18H13ClN4O4S2/c1-23-13-7-2-9(19)8-12(13)14(17(23)25)15-16(24)22-18(28-15)21-10-3-5-11(6-4-10)29(20,26)27/h2-8H,1H3,(H2,20,26,27)(H,21,22,24)/b15-14- BDOJBBOSIURZDQ-PFONDFGASA-N 50456989 CHEMBL4211657 Carbonic anhydrase 4 Homo sapiens 3041 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456989&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145965743 433924256 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117819 NS(=O)(=O)c1ccc(cc1)\N=C1/NC(=O)\C(S1)=C1\C(=O)N(Cc2ccccc2)c2ccc(Cl)cc12 InChI=1S/C24H17ClN4O4S2/c25-15-6-11-19-18(12-15)20(23(31)29(19)13-14-4-2-1-3-5-14)21-22(30)28-24(34-21)27-16-7-9-17(10-8-16)35(26,32)33/h1-12H,13H2,(H2,26,32,33)(H,27,28,30)/b21-20- WOXTYVCOVIDPDA-MRCUWXFGSA-N 50457006 CHEMBL4211148 Carbonic anhydrase 4 Homo sapiens 4306 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457006&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145966173 433924273 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51117826 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2017.07.073 10.7270/Q22F7R2C 28802125 Eldehna, WM; Abo-Ashour, MF; Nocentini, A; Gratteri, P; Eissa, IH; Fares, M; Ismael, OE; Ghabbour, HA; Elaasser, MM; Abdel-Aziz, HA; Supuran, CT Kafrelsheikh University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112327 Cc1cc2ncn(CC(=O)c3cc(c(Cl)cc3Cl)S(N)(=O)=O)c2cc1C InChI=1S/C17H15Cl2N3O3S/c1-9-3-14-15(4-10(9)2)22(8-21-14)7-16(23)11-5-17(26(20,24)25)13(19)6-12(11)18/h3-6,8H,7H2,1-2H3,(H2,20,24,25) KQWDYZRSOUJMMK-UHFFFAOYSA-N 50454305 CHEMBL4210750 Carbonic anhydrase 4 Homo sapiens 2860 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454305&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509658 433922664 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112347 NS(=O)(=O)c1cc(C(=O)Cn2ccnc2)c(Cl)cc1Cl InChI=1S/C11H9Cl2N3O3S/c12-8-4-9(13)11(20(14,18)19)3-7(8)10(17)5-16-2-1-15-6-16/h1-4,6H,5H2,(H2,14,18,19) VMDQSCJPYHQIPE-UHFFFAOYSA-N 50454309 CHEMBL4211504 Carbonic anhydrase 4 Homo sapiens 1560 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454309&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509138 433922668 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112353 NS(=O)(=O)c1cc(ccc1Cl)C(=O)CN1CCCc2ccccc12 InChI=1S/C17H17ClN2O3S/c18-14-8-7-13(10-17(14)24(19,22)23)16(21)11-20-9-3-5-12-4-1-2-6-15(12)20/h1-2,4,6-8,10H,3,5,9,11H2,(H2,19,22,23) MMGNCOIFIVYOIY-UHFFFAOYSA-N 50454307 CHEMBL4203615 Carbonic anhydrase 4 Homo sapiens 3330 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454307&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509632 433922666 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112374 Cc1nc2ccccc2n1CC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O InChI=1S/C16H14ClN3O3S/c1-10-19-13-4-2-3-5-14(13)20(10)9-15(21)11-6-7-12(17)16(8-11)24(18,22)23/h2-8H,9H2,1H3,(H2,18,22,23) TTXDYSSNPNOXIT-UHFFFAOYSA-N 50329831 2-Chloro-5-[(2-methyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide::CHEMBL1272188::N-alkylated benzimidazole derivative, 4b Carbonic anhydrase 4 Homo sapiens 4.1 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329831&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 52943104 123108946 CHEMBL1272188 ZINC64526972 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112472 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 100 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112473 NS(=O)(=O)c1cc(C(=O)Nn2cnc3ccccc23)c(SC2CCCCC2)cc1Cl InChI=1S/C20H21ClN4O3S2/c21-15-11-18(29-13-6-2-1-3-7-13)14(10-19(15)30(22,27)28)20(26)24-25-12-23-16-8-4-5-9-17(16)25/h4-5,8-13H,1-3,6-7H2,(H,24,26)(H2,22,27,28) KTMCVAZXKKRHMA-UHFFFAOYSA-N 50454312 CHEMBL4205449 Carbonic anhydrase 4 Homo sapiens 250 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454312&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145976854 433922671 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112474 NS(=O)(=O)c1cc(C(=O)Nn2cnc3ccccc23)c(Sc2ccccc2)cc1Cl InChI=1S/C20H15ClN4O3S2/c21-15-11-18(29-13-6-2-1-3-7-13)14(10-19(15)30(22,27)28)20(26)24-25-12-23-16-8-4-5-9-17(16)25/h1-12H,(H,24,26)(H2,22,27,28) ROCHHIGKWGQARA-UHFFFAOYSA-N 50454306 CHEMBL4218335 Carbonic anhydrase 4 Homo sapiens 33 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454306&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145968471 433922665 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112497 NS(=O)(=O)c1cc(C(=O)Cn2cnc3ccccc23)c(SCCc2ccccc2)cc1Cl InChI=1S/C23H20ClN3O3S2/c24-18-13-22(31-11-10-16-6-2-1-3-7-16)17(12-23(18)32(25,29)30)21(28)14-27-15-26-19-8-4-5-9-20(19)27/h1-9,12-13,15H,10-11,14H2,(H2,25,29,30) JFFJZAFZPSZSOW-UHFFFAOYSA-N 50454311 CHEMBL4214894 Carbonic anhydrase 4 Homo sapiens 2500 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454311&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508814 433922670 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112498 NS(=O)(=O)c1cc(C(=O)Nn2cnc3ccccc23)c(Cl)cc1Cl InChI=1S/C14H10Cl2N4O3S/c15-9-6-10(16)13(24(17,22)23)5-8(9)14(21)19-20-7-18-11-3-1-2-4-12(11)20/h1-7H,(H,19,21)(H2,17,22,23) AKBIFIJQRGIDLH-UHFFFAOYSA-N 50454308 CHEMBL4207577 Carbonic anhydrase 4 Homo sapiens 500 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454308&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 138377179 433922667 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112499 CCc1nc2ccccc2n1CC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O InChI=1S/C17H16ClN3O3S/c1-2-17-20-13-5-3-4-6-14(13)21(17)10-15(22)11-7-8-12(18)16(9-11)25(19,23)24/h3-9H,2,10H2,1H3,(H2,19,23,24) TYAOADJQLFNTDS-UHFFFAOYSA-N 50329823 2-Chloro-5-[(2-ethyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide::CHEMBL1272243::N-alkylated benzimidazole derivative, 4e Carbonic anhydrase 4 Homo sapiens 1330 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329823&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 52944687 123108938 CHEMBL1272243 ZINC64527445 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112500 Cc1nc2ccccc2n1CC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O InChI=1S/C16H14ClN3O3S/c1-10-19-13-4-2-3-5-14(13)20(10)9-15(21)11-6-7-12(17)16(8-11)24(18,22)23/h2-8H,9H2,1H3,(H2,18,22,23) TTXDYSSNPNOXIT-UHFFFAOYSA-N 50329831 2-Chloro-5-[(2-methyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide::CHEMBL1272188::N-alkylated benzimidazole derivative, 4b Carbonic anhydrase 4 Homo sapiens 952 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329831&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 52943104 123108946 CHEMBL1272188 ZINC64526972 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112501 NS(=O)(=O)c1cc(ccc1Cl)C(=O)Cn1cnc(c1-c1ccccc1)-c1ccccc1 InChI=1S/C23H18ClN3O3S/c24-19-12-11-18(13-21(19)31(25,29)30)20(28)14-27-15-26-22(16-7-3-1-4-8-16)23(27)17-9-5-2-6-10-17/h1-13,15H,14H2,(H2,25,29,30) OFPBAPQNOPKYNZ-UHFFFAOYSA-N 50454313 CHEMBL4216585 Carbonic anhydrase 4 Homo sapiens 200000 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454313&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509769 433922672 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112502 NS(=O)(=O)c1cc(ccc1Cl)C(=O)Cn1ccnc1-c1ccccc1 InChI=1S/C17H14ClN3O3S/c18-14-7-6-13(10-16(14)25(19,23)24)15(22)11-21-9-8-20-17(21)12-4-2-1-3-5-12/h1-10H,11H2,(H2,19,23,24) CUNWRSNMYCCCRX-UHFFFAOYSA-N 50454304 CHEMBL4204892 Carbonic anhydrase 4 Homo sapiens 2220 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454304&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509157 433922663 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112503 CCc1nccn1CC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O InChI=1S/C13H14ClN3O3S/c1-2-13-16-5-6-17(13)8-11(18)9-3-4-10(14)12(7-9)21(15,19)20/h3-7H,2,8H2,1H3,(H2,15,19,20) IMQFUBXBYVBNLS-UHFFFAOYSA-N 50454292 CHEMBL4208414 Carbonic anhydrase 4 Homo sapiens 11100 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454292&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509884 433922661 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112504 NS(=O)(=O)c1cc(ccc1Cl)C(=O)Cn1cnc2ccccc12 InChI=1S/C15H12ClN3O3S/c16-11-6-5-10(7-15(11)23(17,21)22)14(20)8-19-9-18-12-3-1-2-4-13(12)19/h1-7,9H,8H2,(H2,17,21,22) XXDZSNJTAQNIAQ-UHFFFAOYSA-N 50329832 5-(1H-Benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide::CHEMBL1272187::N-alkylated benzimidazole derivative, 4a::carbonic anhydrase (CA) inhibitors, benzenesulphonamide ligand, 4 Carbonic anhydrase 4 Homo sapiens 719 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329832&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search E02 3M98 50904886 123108947 CHEMBL1272187 ZINC64526986 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112600 NS(=O)(=O)c1cc(C(=O)Nn2cnc3ccccc23)c(SC2CCCCC2)cc1Cl InChI=1S/C20H21ClN4O3S2/c21-15-11-18(29-13-6-2-1-3-7-13)14(10-19(15)30(22,27)28)20(26)24-25-12-23-16-8-4-5-9-17(16)25/h4-5,8-13H,1-3,6-7H2,(H,24,26)(H2,22,27,28) KTMCVAZXKKRHMA-UHFFFAOYSA-N 50454312 CHEMBL4205449 Carbonic anhydrase 4 Homo sapiens 1.1 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454312&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145976854 433922671 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112601 NS(=O)(=O)c1cc(C(=O)Nn2cnc3ccccc23)c(Sc2ccccc2)cc1Cl InChI=1S/C20H15ClN4O3S2/c21-15-11-18(29-13-6-2-1-3-7-13)14(10-19(15)30(22,27)28)20(26)24-25-12-23-16-8-4-5-9-17(16)25/h1-12H,(H,24,26)(H2,22,27,28) ROCHHIGKWGQARA-UHFFFAOYSA-N 50454306 CHEMBL4218335 Carbonic anhydrase 4 Homo sapiens 0.140000 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454306&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145968471 433922665 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112602 Cc1cc2ncn(CC(=O)c3cc(c(Cl)cc3Sc3ccccc3)S(N)(=O)=O)c2cc1C InChI=1S/C23H20ClN3O3S2/c1-14-8-19-20(9-15(14)2)27(13-26-19)12-21(28)17-10-23(32(25,29)30)18(24)11-22(17)31-16-6-4-3-5-7-16/h3-11,13H,12H2,1-2H3,(H2,25,29,30) AGMAPYKKSIMHTM-UHFFFAOYSA-N 50454291 CHEMBL4207242 Carbonic anhydrase 4 Homo sapiens 854 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454291&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126510084 433922660 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112603 NS(=O)(=O)c1cc(C(=O)Cn2ccnc2)c(Cl)cc1Cl InChI=1S/C11H9Cl2N3O3S/c12-8-4-9(13)11(20(14,18)19)3-7(8)10(17)5-16-2-1-15-6-16/h1-4,6H,5H2,(H2,14,18,19) VMDQSCJPYHQIPE-UHFFFAOYSA-N 50454309 CHEMBL4211504 Carbonic anhydrase 4 Homo sapiens 20 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454309&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509138 433922668 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112604 NS(=O)(=O)c1cc(C(=O)Cn2cnc3ccccc23)c(Cl)cc1Cl InChI=1S/C15H11Cl2N3O3S/c16-10-6-11(17)15(24(18,22)23)5-9(10)14(21)7-20-8-19-12-3-1-2-4-13(12)20/h1-6,8H,7H2,(H2,18,22,23) YAIQQAHCNJQINN-UHFFFAOYSA-N 50454303 CHEMBL4207063 Carbonic anhydrase 4 Homo sapiens 15 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454303&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508232 433922662 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112605 NS(=O)(=O)c1cc(ccc1Cl)C(=O)CN1CCCc2ccccc12 InChI=1S/C17H17ClN2O3S/c18-14-8-7-13(10-17(14)24(19,22)23)16(21)11-20-9-3-5-12-4-1-2-6-15(12)20/h1-2,4,6-8,10H,3,5,9,11H2,(H2,19,22,23) MMGNCOIFIVYOIY-UHFFFAOYSA-N 50454307 CHEMBL4203615 Carbonic anhydrase 4 Homo sapiens 14 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454307&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509632 433922666 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112606 NS(=O)(=O)c1cc(ccc1Cl)C(=O)CN1CCc2ccccc12 InChI=1S/C16H15ClN2O3S/c17-13-6-5-12(9-16(13)23(18,21)22)15(20)10-19-8-7-11-3-1-2-4-14(11)19/h1-6,9H,7-8,10H2,(H2,18,21,22) IUJZGQBCUQCFFX-UHFFFAOYSA-N 50454314 CHEMBL4215863 Carbonic anhydrase 4 Homo sapiens 0.660000 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454314&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509556 433922673 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112607 NS(=O)(=O)c1cc(ccc1Cl)C(=O)Cn1cnc(c1-c1ccccc1)-c1ccccc1 InChI=1S/C23H18ClN3O3S/c24-19-12-11-18(13-21(19)31(25,29)30)20(28)14-27-15-26-22(16-7-3-1-4-8-16)23(27)17-9-5-2-6-10-17/h1-13,15H,14H2,(H2,25,29,30) OFPBAPQNOPKYNZ-UHFFFAOYSA-N 50454313 CHEMBL4216585 Carbonic anhydrase 4 Homo sapiens 854 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454313&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509769 433922672 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112608 NS(=O)(=O)c1cc(ccc1Cl)C(=O)Cn1ccnc1 InChI=1S/C11H10ClN3O3S/c12-9-2-1-8(5-11(9)19(13,17)18)10(16)6-15-4-3-14-7-15/h1-5,7H,6H2,(H2,13,17,18) GQFZORNDUUPFQK-UHFFFAOYSA-N 50454315 CHEMBL4204729 Carbonic anhydrase 4 Homo sapiens 0.360000 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454315&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509254 433922674 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112609 Cc1cc2ncn(CC(=O)c3ccc(Cl)c(c3)S(N)(=O)=O)c2cc1C InChI=1S/C17H16ClN3O3S/c1-10-5-14-15(6-11(10)2)21(9-20-14)8-16(22)12-3-4-13(18)17(7-12)25(19,23)24/h3-7,9H,8H2,1-2H3,(H2,19,23,24) FOUZNIKKWIYYLK-UHFFFAOYSA-N 50454310 CHEMBL4205044 Carbonic anhydrase 4 Homo sapiens 14 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454310&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509934 433922669 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112634 Cc1cc2ncn(CC(=O)c3cc(c(Cl)cc3Cl)S(N)(=O)=O)c2cc1C InChI=1S/C17H15Cl2N3O3S/c1-9-3-14-15(4-10(9)2)22(8-21-14)7-16(23)11-5-17(26(20,24)25)13(19)6-12(11)18/h3-6,8H,7H2,1-2H3,(H2,20,24,25) KQWDYZRSOUJMMK-UHFFFAOYSA-N 50454305 CHEMBL4210750 Carbonic anhydrase 4 Homo sapiens 37 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454305&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509658 433922664 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112635 CCc1nccn1CC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O InChI=1S/C13H14ClN3O3S/c1-2-13-16-5-6-17(13)8-11(18)9-3-4-10(14)12(7-9)21(15,19)20/h3-7H,2,8H2,1H3,(H2,15,19,20) IMQFUBXBYVBNLS-UHFFFAOYSA-N 50454292 CHEMBL4208414 Carbonic anhydrase 4 Homo sapiens 48 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454292&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509884 433922661 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112679 CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23) NDDAHWYSQHTHNT-UHFFFAOYSA-N 25901 4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide::Indaflex::Indapamide::Indapamide (2)::Lozol::Noranat Carbonic anhydrase 4 Homo sapiens 0.330000 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25901&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BL1 3BL1 3702 56413189 5893 DB00808 7203 ZINC00643114 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112680 NS(=O)(=O)c1cc(C(=O)Cn2cnc3ccccc23)c(SCCc2ccccc2)cc1Cl InChI=1S/C23H20ClN3O3S2/c24-18-13-22(31-11-10-16-6-2-1-3-7-16)17(12-23(18)32(25,29)30)21(28)14-27-15-26-19-8-4-5-9-20(19)27/h1-9,12-13,15H,10-11,14H2,(H2,25,29,30) JFFJZAFZPSZSOW-UHFFFAOYSA-N 50454311 CHEMBL4214894 Carbonic anhydrase 4 Homo sapiens 11 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454311&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508814 433922670 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112681 CCc1nc2ccccc2n1CC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O InChI=1S/C17H16ClN3O3S/c1-2-17-20-13-5-3-4-6-14(13)21(17)10-15(22)11-7-8-12(18)16(9-11)25(19,23)24/h3-9H,2,10H2,1H3,(H2,19,23,24) TYAOADJQLFNTDS-UHFFFAOYSA-N 50329823 2-Chloro-5-[(2-ethyl-1H-benzimidazol-1-yl)acetyl]benzenesulfonamide::CHEMBL1272243::N-alkylated benzimidazole derivative, 4e Carbonic anhydrase 4 Homo sapiens 5.7 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329823&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 52944687 123108938 CHEMBL1272243 ZINC64527445 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112682 NS(=O)(=O)c1cc(ccc1Cl)C(=O)Cn1ccnc1-c1ccccc1 InChI=1S/C17H14ClN3O3S/c18-14-7-6-13(10-16(14)25(19,23)24)15(22)11-21-9-8-20-17(21)12-4-2-1-3-5-12/h1-10H,11H2,(H2,19,23,24) CUNWRSNMYCCCRX-UHFFFAOYSA-N 50454304 CHEMBL4204892 Carbonic anhydrase 4 Homo sapiens 9.5 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454304&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509157 433922663 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112701 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 14 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112721 NS(=O)(=O)c1cc(ccc1Cl)C(=O)Cn1ccnc1 InChI=1S/C11H10ClN3O3S/c12-9-2-1-8(5-11(9)19(13,17)18)10(16)6-15-4-3-14-7-15/h1-5,7H,6H2,(H2,13,17,18) GQFZORNDUUPFQK-UHFFFAOYSA-N 50454315 CHEMBL4204729 Carbonic anhydrase 4 Homo sapiens 83 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454315&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509254 433922674 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112746 CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23) NDDAHWYSQHTHNT-UHFFFAOYSA-N 25901 4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide::Indaflex::Indapamide::Indapamide (2)::Lozol::Noranat Carbonic anhydrase 4 Homo sapiens 77 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25901&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BL1 3BL1 3702 56413189 5893 DB00808 7203 ZINC00643114 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112747 Cc1cc2ncn(CC(=O)c3cc(c(Cl)cc3Sc3ccccc3)S(N)(=O)=O)c2cc1C InChI=1S/C23H20ClN3O3S2/c1-14-8-19-20(9-15(14)2)27(13-26-19)12-21(28)17-10-23(32(25,29)30)18(24)11-22(17)31-16-6-4-3-5-7-16/h3-11,13H,12H2,1-2H3,(H2,25,29,30) AGMAPYKKSIMHTM-UHFFFAOYSA-N 50454291 CHEMBL4207242 Carbonic anhydrase 4 Homo sapiens 200000 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454291&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126510084 433922660 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112752 NS(=O)(=O)c1cc(C(=O)Cn2cnc3ccccc23)c(Cl)cc1Cl InChI=1S/C15H11Cl2N3O3S/c16-10-6-11(17)15(24(18,22)23)5-9(10)14(21)7-20-8-19-12-3-1-2-4-13(12)20/h1-6,8H,7H2,(H2,18,22,23) YAIQQAHCNJQINN-UHFFFAOYSA-N 50454303 CHEMBL4207063 Carbonic anhydrase 4 Homo sapiens 1110 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454303&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508232 433922662 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112753 NS(=O)(=O)c1cc(ccc1Cl)C(=O)CN1CCc2ccccc12 InChI=1S/C16H15ClN2O3S/c17-13-6-5-12(9-16(13)23(18,21)22)15(20)10-19-8-7-11-3-1-2-4-14(11)19/h1-6,9H,7-8,10H2,(H2,18,21,22) IUJZGQBCUQCFFX-UHFFFAOYSA-N 50454314 CHEMBL4215863 Carbonic anhydrase 4 Homo sapiens 154 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454314&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509556 433922673 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51112754 Cc1cc2ncn(CC(=O)c3ccc(Cl)c(c3)S(N)(=O)=O)c2cc1C InChI=1S/C17H16ClN3O3S/c1-10-5-14-15(6-11(10)2)21(9-20-14)8-16(22)12-3-4-13(18)17(7-12)25(19,23)24/h3-7,9H,8H2,1-2H3,(H2,19,23,24) FOUZNIKKWIYYLK-UHFFFAOYSA-N 50454310 CHEMBL4205044 Carbonic anhydrase 4 Homo sapiens 3330 ChEMBL 10.1016/j.bmc.2017.12.035 10.7270/Q2H997S0 29305297 Čapkauskaitė, E; Zakšauskas, A; Ruibys, V; Linkuvienė, V; Paketurytė, V; Gedgaudas, M; Kairys, V; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454310&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509934 433922669 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118522 NS(=O)(=O)c1ccc(NC(=S)Nc2ccc(F)cc2)cc1 InChI=1S/C13H12FN3O2S2/c14-9-1-3-10(4-2-9)16-13(20)17-11-5-7-12(8-6-11)21(15,18)19/h1-8H,(H2,15,18,19)(H2,16,17,20) VUDOFEJVAFMLEC-UHFFFAOYSA-N 50457329 CHEMBL4209613 Carbonic anhydrase 4 Homo sapiens 4797 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457329&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 8JS 7NEX,5ULN,5WEX 730546 433924596 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118523 NS(=O)(=O)c1cccc(NC(=[Se])Nc2ccccc2)c1 InChI=1S/C13H13N3O2SSe/c14-19(17,18)12-8-4-7-11(9-12)16-13(20)15-10-5-2-1-3-6-10/h1-9H,(H2,14,17,18)(H2,15,16,20) ZNJCOPMXQMVMNA-UHFFFAOYSA-N 50457330 CHEMBL4211035 Carbonic anhydrase 4 Homo sapiens 909 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457330&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145964779 433924597 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118524 NS(=O)(=O)c1ccc(NC(=[Se])Nc2ccc(F)cc2)cc1 InChI=1S/C13H12FN3O2SSe/c14-9-1-3-10(4-2-9)16-13(21)17-11-5-7-12(8-6-11)20(15,18)19/h1-8H,(H2,15,18,19)(H2,16,17,21) WEUISFFZQUMPMK-UHFFFAOYSA-N 50457331 CHEMBL4212937 Carbonic anhydrase 4 Homo sapiens 7557 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457331&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search U3N 7BM4 145966250 433924598 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118528 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118529 NS(=O)(=O)c1ccc(CCNC(=[Se])Nc2ccc(Br)cc2)cc1 InChI=1S/C15H16BrN3O2SSe/c16-12-3-5-13(6-4-12)19-15(23)18-10-9-11-1-7-14(8-2-11)22(17,20)21/h1-8H,9-10H2,(H2,17,20,21)(H2,18,19,23) HPYJTKWZURJRTO-UHFFFAOYSA-N 50457328 CHEMBL4204740 Carbonic anhydrase 4 Homo sapiens 1409 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457328&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145975591 433924595 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118560 NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(F)cc2)cc1 InChI=1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18) YJQZNWPYLCNRLP-UHFFFAOYSA-N 50334354 4-(3-(4-fluorophenyl)ureido)benzenesulfonamide::4-{[(4'-Fluorophenyl)carbamoyl]amino}benzenesulfonamide::4-{[(4-fluorophenyl)carbamoyl]amino}benzenesulfonamide::CHEMBL1615281 Carbonic anhydrase 4 Homo sapiens 286 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334354&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search WWZ 3N4B,7NWY,5JN3 310360 125084456 CHEMBL1615281 ZINC01752601 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118561 NS(=O)(=O)c1ccc(CCNC(=[Se])Nc2ccc(I)cc2)cc1 InChI=1S/C15H16IN3O2SSe/c16-12-3-5-13(6-4-12)19-15(23)18-10-9-11-1-7-14(8-2-11)22(17,20)21/h1-8H,9-10H2,(H2,17,20,21)(H2,18,19,23) FXNHQTUZYHDCOC-UHFFFAOYSA-N 50457333 CHEMBL4214017 Carbonic anhydrase 4 Homo sapiens 6760 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457333&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145964671 433924600 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118562 COc1ccccc1NC(=[Se])NCCc1ccc(cc1)S(N)(=O)=O InChI=1S/C16H19N3O3SSe/c1-22-15-5-3-2-4-14(15)19-16(24)18-11-10-12-6-8-13(9-7-12)23(17,20)21/h2-9H,10-11H2,1H3,(H2,17,20,21)(H2,18,19,24) LPKQBPKULCOWBZ-UHFFFAOYSA-N 50457337 CHEMBL4206680 Carbonic anhydrase 4 Homo sapiens 766 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457337&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145976656 433924604 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118563 NS(=O)(=O)c1ccc(CCNC(=[Se])Nc2ccccc2Cl)cc1 InChI=1S/C15H16ClN3O2SSe/c16-13-3-1-2-4-14(13)19-15(23)18-10-9-11-5-7-12(8-6-11)22(17,20)21/h1-8H,9-10H2,(H2,17,20,21)(H2,18,19,23) XAVUUMXOBISVGB-UHFFFAOYSA-N 50457335 CHEMBL4218419 Carbonic anhydrase 4 Homo sapiens 731 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457335&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145968245 433924602 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118564 NS(=O)(=O)c1ccc(CCNC(=[Se])Nc2ccccc2F)cc1 InChI=1S/C15H16FN3O2SSe/c16-13-3-1-2-4-14(13)19-15(23)18-10-9-11-5-7-12(8-6-11)22(17,20)21/h1-8H,9-10H2,(H2,17,20,21)(H2,18,19,23) LTFOMIRKXUJVML-UHFFFAOYSA-N 50457339 CHEMBL4210025 Carbonic anhydrase 4 Homo sapiens 898 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457339&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145964063 433924606 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118565 NS(=O)(=O)c1ccc(NC(=[Se])Nc2ccccc2Cl)cc1 InChI=1S/C13H12ClN3O2SSe/c14-11-3-1-2-4-12(11)17-13(21)16-9-5-7-10(8-6-9)20(15,18)19/h1-8H,(H2,15,18,19)(H2,16,17,21) IGUMMNSKDYOIFF-UHFFFAOYSA-N 50457327 CHEMBL4214412 Carbonic anhydrase 4 Homo sapiens 269 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457327&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145973882 433924594 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118566 NS(=O)(=O)c1ccc(NC(=[Se])Nc2ccccc2F)cc1 InChI=1S/C13H12FN3O2SSe/c14-11-3-1-2-4-12(11)17-13(21)16-9-5-7-10(8-6-9)20(15,18)19/h1-8H,(H2,15,18,19)(H2,16,17,21) ZDNQYUWUOIULJX-UHFFFAOYSA-N 50457340 CHEMBL4217879 Carbonic anhydrase 4 Homo sapiens 902 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457340&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145974992 433924607 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118567 NS(=O)(=O)c1cccc(NC(=[Se])Nc2ccc(F)cc2)c1 InChI=1S/C13H12FN3O2SSe/c14-9-4-6-10(7-5-9)16-13(21)17-11-2-1-3-12(8-11)20(15,18)19/h1-8H,(H2,15,18,19)(H2,16,17,21) HUUXUXXAJDJHRN-UHFFFAOYSA-N 50457341 CHEMBL4217357 Carbonic anhydrase 4 Homo sapiens 766 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457341&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145974949 433924608 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118575 NS(=O)(=O)c1ccc(CCNC(=[Se])Nc2ccc3ccccc3c2)cc1 InChI=1S/C19H19N3O2SSe/c20-25(23,24)18-9-5-14(6-10-18)11-12-21-19(26)22-17-8-7-15-3-1-2-4-16(15)13-17/h1-10,13H,11-12H2,(H2,20,23,24)(H2,21,22,26) YZQYBFZSTJRDFZ-UHFFFAOYSA-N 50457336 CHEMBL4218935 Carbonic anhydrase 4 Homo sapiens 5423 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457336&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145968026 433924603 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118576 NS(=O)(=O)c1ccc(CCNC(=[Se])Nc2cccc(c2)C(F)(F)F)cc1 InChI=1S/C16H16F3N3O2SSe/c17-16(18,19)12-2-1-3-13(10-12)22-15(26)21-9-8-11-4-6-14(7-5-11)25(20,23)24/h1-7,10H,8-9H2,(H2,20,23,24)(H2,21,22,26) QXZHBTKZNJXXJP-UHFFFAOYSA-N 50457338 CHEMBL4216411 Carbonic anhydrase 4 Homo sapiens 929 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457338&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145974672 433924605 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118577 NS(=O)(=O)c1ccc(NC(=[Se])Nc2cccc(c2)C(F)(F)F)cc1 InChI=1S/C14H12F3N3O2SSe/c15-14(16,17)9-2-1-3-11(8-9)20-13(24)19-10-4-6-12(7-5-10)23(18,21)22/h1-8H,(H2,18,21,22)(H2,19,20,24) ONEFRVPFPAIKEO-UHFFFAOYSA-N 50457332 CHEMBL4209499 Carbonic anhydrase 4 Homo sapiens 734 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457332&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145964275 433924599 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118580 NS(=O)(=O)c1ccc(NC(=[Se])Nc2ccccc2)cc1 InChI=1S/C13H13N3O2SSe/c14-19(17,18)12-8-6-11(7-9-12)16-13(20)15-10-4-2-1-3-5-10/h1-9H,(H2,14,17,18)(H2,15,16,20) OYTLEMICGIEKBU-UHFFFAOYSA-N 50457334 CHEMBL4205654 Carbonic anhydrase 4 Homo sapiens 8627 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457334&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145977869 433924601 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51118583 NS(=O)(=O)c1ccc(CCNC(=[Se])Nc2ccccc2)cc1 InChI=1S/C15H17N3O2SSe/c16-21(19,20)14-8-6-12(7-9-14)10-11-17-15(22)18-13-4-2-1-3-5-13/h1-9H,10-11H2,(H2,16,19,20)(H2,17,18,22) YXYIHTNVQREZHT-UHFFFAOYSA-N 50457342 CHEMBL4205129 Carbonic anhydrase 4 Homo sapiens 1782 ChEMBL 10.1021/acsmedchemlett.7b00280 10.7270/Q2TT4TKD 28947945 Angeli, A; Tanini, D; Peat, TS; Di Cesare Mannelli, L; Bartolucci, G; Capperucci, A; Ghelardini, C; Supuran, CT; Carta, F University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50457342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50457342&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 131839635 433924609 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102695 NS(=O)(=O)c1cc(C(=O)NCCCO)c(Cl)cc1Cl InChI=1S/C10H12Cl2N2O4S/c11-7-5-8(12)9(19(13,17)18)4-6(7)10(16)14-2-1-3-15/h4-5,15H,1-3H2,(H,14,16)(H2,13,17,18) OZBGWVAREHIEDY-UHFFFAOYSA-N 50449827 CHEMBL4173471 Carbonic anhydrase 4 Homo sapiens 7.1 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449827&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508709 433919389 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102696 NS(=O)(=O)c1cc(C(=O)N2CCOCC2)c(Cl)cc1Cl InChI=1S/C11H12Cl2N2O4S/c12-8-6-9(13)10(20(14,17)18)5-7(8)11(16)15-1-3-19-4-2-15/h5-6H,1-4H2,(H2,14,17,18) AVTRWXCLWDQMCF-UHFFFAOYSA-N 50449830 CHEMBL4173814 Carbonic anhydrase 4 Homo sapiens 333 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449830&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 60635890 433919392 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102697 NS(=O)(=O)c1cc(C(=O)NCCO)c(Br)cc1Br InChI=1S/C9H10Br2N2O4S/c10-6-4-7(11)8(18(12,16)17)3-5(6)9(15)13-1-2-14/h3-4,14H,1-2H2,(H,13,15)(H2,12,16,17) FASQQHIRLIBRPZ-UHFFFAOYSA-N 50449809 CHEMBL4168997 Carbonic anhydrase 4 Homo sapiens 111 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449809&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509027 433919372 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102698 NS(=O)(=O)c1cc(C(=O)NCCCC(O)=O)c(Cl)cc1Cl InChI=1S/C11H12Cl2N2O5S/c12-7-5-8(13)9(21(14,19)20)4-6(7)11(18)15-3-1-2-10(16)17/h4-5H,1-3H2,(H,15,18)(H,16,17)(H2,14,19,20) AZHHAHHRNOQVSO-UHFFFAOYSA-N 50449821 CHEMBL4168586 Carbonic anhydrase 4 Homo sapiens 280 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449821&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508712 433919384 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51097373 NS(=O)(=O)c1ccc(cc1)-n1ncc2CCc3nc(ncc3-c12)-c1ccccc1 InChI=1S/C21H17N5O2S/c22-29(27,28)17-9-7-16(8-10-17)26-20-15(12-24-26)6-11-19-18(20)13-23-21(25-19)14-4-2-1-3-5-14/h1-5,7-10,12-13H,6,11H2,(H2,22,27,28) LRDIQEWKBOSAJO-UHFFFAOYSA-N 50341398 CHEMBL4170566 Carbonic anhydrase 4 Homo sapiens 7229 ChEMBL 10.1021/acs.jmedchem.8b00670 10.7270/Q2DB84F9 29912561 Salerno, S; Barresi, E; Amendola, G; Berrino, E; Milite, C; Marini, AM; Da Settimo, F; Novellino, E; Supuran, CT; Cosconati, S; Taliani, S Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341398&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145956081 131344334 ZINC15919880 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51097374 NS(=O)(=O)c1ccc(cc1)-n1ncc2c1CC(CC2=O)c1ccccc1 InChI=1S/C19H17N3O3S/c20-26(24,25)16-8-6-15(7-9-16)22-18-10-14(13-4-2-1-3-5-13)11-19(23)17(18)12-21-22/h1-9,12,14H,10-11H2,(H2,20,24,25) OPUYATOWSQLHRR-UHFFFAOYSA-N 50341401 CHEMBL4165351 Carbonic anhydrase 4 Homo sapiens 214 ChEMBL 10.1021/acs.jmedchem.8b00670 10.7270/Q2DB84F9 29912561 Salerno, S; Barresi, E; Amendola, G; Berrino, E; Milite, C; Marini, AM; Da Settimo, F; Novellino, E; Supuran, CT; Cosconati, S; Taliani, S Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341401&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145952846 131344337 ZINC20661391 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51097375 NS(=O)(=O)c1ccc(Nc2ncc3C(=O)CCCc3n2)cc1 InChI=1S/C14H14N4O3S/c15-22(20,21)10-6-4-9(5-7-10)17-14-16-8-11-12(18-14)2-1-3-13(11)19/h4-8H,1-3H2,(H2,15,20,21)(H,16,17,18) LJWVCXMFRNTURZ-UHFFFAOYSA-N 50341403 CHEMBL4173265 Carbonic anhydrase 4 Homo sapiens 73 ChEMBL 10.1021/acs.jmedchem.8b00670 10.7270/Q2DB84F9 29912561 Salerno, S; Barresi, E; Amendola, G; Berrino, E; Milite, C; Marini, AM; Da Settimo, F; Novellino, E; Supuran, CT; Cosconati, S; Taliani, S Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341403&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145950373 131344339 ZINC36023281 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51097376 NS(=O)(=O)c1ccc(Nc2ncc3C(=O)CC(Cc3n2)c2ccccc2)cc1 InChI=1S/C20H18N4O3S/c21-28(26,27)16-8-6-15(7-9-16)23-20-22-12-17-18(24-20)10-14(11-19(17)25)13-4-2-1-3-5-13/h1-9,12,14H,10-11H2,(H2,21,26,27)(H,22,23,24) XCFORMSCJJLJAW-UHFFFAOYSA-N 50341405 CHEMBL4169838 Carbonic anhydrase 4 Homo sapiens 78 ChEMBL 10.1021/acs.jmedchem.8b00670 10.7270/Q2DB84F9 29912561 Salerno, S; Barresi, E; Amendola, G; Berrino, E; Milite, C; Marini, AM; Da Settimo, F; Novellino, E; Supuran, CT; Cosconati, S; Taliani, S Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341405&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145953493 131344341 ZINC20408230 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51097377 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.8b00670 10.7270/Q2DB84F9 29912561 Salerno, S; Barresi, E; Amendola, G; Berrino, E; Milite, C; Marini, AM; Da Settimo, F; Novellino, E; Supuran, CT; Cosconati, S; Taliani, S Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51097387 NS(=O)(=O)c1ccc(cc1)-n1ncc2CCc3ncncc3-c12 InChI=1S/C15H13N5O2S/c16-23(21,22)12-4-2-11(3-5-12)20-15-10(7-19-20)1-6-14-13(15)8-17-9-18-14/h2-5,7-9H,1,6H2,(H2,16,21,22) DBFSWXVTZGGBKB-UHFFFAOYSA-N 50341402 CHEMBL4167173 Carbonic anhydrase 4 Homo sapiens 7.1 ChEMBL 10.1021/acs.jmedchem.8b00670 10.7270/Q2DB84F9 29912561 Salerno, S; Barresi, E; Amendola, G; Berrino, E; Milite, C; Marini, AM; Da Settimo, F; Novellino, E; Supuran, CT; Cosconati, S; Taliani, S Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341402&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145953837 131344338 ZINC18181421 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102755 NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl InChI=1S/C7H5Cl2NO4S/c8-4-2-5(9)6(15(10,13)14)1-3(4)7(11)12/h1-2H,(H,11,12)(H2,10,13,14) ZSHHRBYVHTVRFK-UHFFFAOYSA-N 13075 2,4-dichloro-5-sulfamoylbenzoic acid::2000-01951::Lasamide (Hsba)::LeadQuest Compound 9 Carbonic anhydrase 4 Homo sapiens 1500 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13075&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 17655 46513492 ZINC01088182 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102756 NS(=O)(=O)c1cc(C(O)=O)c(NC2CCCCCCC2)cc1Cl InChI=1S/C15H21ClN2O4S/c16-12-9-13(18-10-6-4-2-1-3-5-7-10)11(15(19)20)8-14(12)23(17,21)22/h8-10,18H,1-7H2,(H,19,20)(H2,17,21,22) IBXZMQXWKGWYDC-UHFFFAOYSA-N 50449825 CHEMBL4160627 Carbonic anhydrase 4 Homo sapiens 3330 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449825&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145956924 433919387 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102757 NS(=O)(=O)c1cc(C(O)=O)c(Br)cc1Br InChI=1S/C7H5Br2NO4S/c8-4-2-5(9)6(15(10,13)14)1-3(4)7(11)12/h1-2H,(H,11,12)(H2,10,13,14) NJWAUKHMSHZTLQ-UHFFFAOYSA-N 50449811 CHEMBL4165127 Carbonic anhydrase 4 Homo sapiens 1170 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449811&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507856 433919374 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102758 NC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C7H6Cl2N2O3S/c8-4-2-5(9)6(15(11,13)14)1-3(4)7(10)12/h1-2H,(H2,10,12)(H2,11,13,14) IPRGYSAYIGOGMN-UHFFFAOYSA-N 50449822 CHEMBL4175740 Carbonic anhydrase 4 Homo sapiens 263 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449822&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12698190 433919385 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102759 NS(=O)(=O)c1cc(C(=O)NCCO)c(Cl)cc1Cl InChI=1S/C9H10Cl2N2O4S/c10-6-4-7(11)8(18(12,16)17)3-5(6)9(15)13-1-2-14/h3-4,14H,1-2H2,(H,13,15)(H2,12,16,17) UISZEPPPNAJTCZ-UHFFFAOYSA-N 50449831 CHEMBL4172331 Carbonic anhydrase 4 Homo sapiens 400 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449831&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12698192 433919393 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102760 CCCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C11H14Cl2N2O3S/c1-2-3-4-15-11(16)7-5-10(19(14,17)18)9(13)6-8(7)12/h5-6H,2-4H2,1H3,(H,15,16)(H2,14,17,18) KRIUYRKSVUBELV-UHFFFAOYSA-N 50449816 CHEMBL4160149 Carbonic anhydrase 4 Homo sapiens 83 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449816&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ENN 6G5U,6G6T 34852311 433919379 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102761 COCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C10H12Cl2N2O4S/c1-18-3-2-14-10(15)6-4-9(19(13,16)17)8(12)5-7(6)11/h4-5H,2-3H2,1H3,(H,14,15)(H2,13,16,17) WVMBHAOCSXODMK-UHFFFAOYSA-N 50449829 CHEMBL4166964 Carbonic anhydrase 4 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449829&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 21189414 433919391 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102762 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C12H14Cl2N2O5S/c1-21-11(17)3-2-4-16-12(18)7-5-10(22(15,19)20)9(14)6-8(7)13/h5-6H,2-4H2,1H3,(H,16,18)(H2,15,19,20) HPOYDHZZGCZYRF-UHFFFAOYSA-N 50449818 CHEMBL4165896 Carbonic anhydrase 4 Homo sapiens 111 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449818&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508879 433919381 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102763 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(Cl)cc1Cl InChI=1S/C13H16Cl2N2O3S/c14-10-7-11(15)12(21(16,19)20)6-9(10)13(18)17-8-4-2-1-3-5-8/h6-8H,1-5H2,(H,17,18)(H2,16,19,20) FYPYZSIHTPQQDJ-UHFFFAOYSA-N 50449834 CHEMBL4173501 Carbonic anhydrase 4 Homo sapiens 167 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449834&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 60635034 433919396 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102764 NS(=O)(=O)c1cc(C(=O)NCc2ccccc2)c(Cl)cc1Cl InChI=1S/C14H12Cl2N2O3S/c15-11-7-12(16)13(22(17,20)21)6-10(11)14(19)18-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,18,19)(H2,17,20,21) RJDMKEUKPUTKRX-UHFFFAOYSA-N 50449819 CHEMBL4165570 Carbonic anhydrase 4 Homo sapiens 22 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449819&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507182 433919382 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102765 CCCCNC(=O)c1cc(c(Br)cc1Br)S(N)(=O)=O InChI=1S/C11H14Br2N2O3S/c1-2-3-4-15-11(16)7-5-10(19(14,17)18)9(13)6-8(7)12/h5-6H,2-4H2,1H3,(H,15,16)(H2,14,17,18) QKIXSEIIKHMOKR-UHFFFAOYSA-N 50449836 CHEMBL4166643 Carbonic anhydrase 4 Homo sapiens 50 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449836&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509349 433919398 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102766 CCCCNC(=O)c1cc(c(Br)cc1NC1CCCCC1)S(N)(=O)=O InChI=1S/C17H26BrN3O3S/c1-2-3-9-20-17(22)13-10-16(25(19,23)24)14(18)11-15(13)21-12-7-5-4-6-8-12/h10-12,21H,2-9H2,1H3,(H,20,22)(H2,19,23,24) ALNLRWSQPFMDQS-UHFFFAOYSA-N 50449820 CHEMBL4177268 Carbonic anhydrase 4 Homo sapiens 3820 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449820&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507636 433919383 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102767 CC(=O)OCCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C12H14Cl2N2O5S/c1-7(17)21-4-2-3-16-12(18)8-5-11(22(15,19)20)10(14)6-9(8)13/h5-6H,2-4H2,1H3,(H,16,18)(H2,15,19,20) ZYZYGWWRCWBUMZ-UHFFFAOYSA-N 50449810 CHEMBL4162133 Carbonic anhydrase 4 Homo sapiens 50 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449810&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507183 433919373 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100643 NS(=O)(=O)c1ccc(N\N=C(/CS(=O)(=O)c2ccccc2)c2ccc(cc2)[N+]([O-])=O)cc1 InChI=1S/C20H18N4O6S2/c21-32(29,30)19-12-8-16(9-13-19)22-23-20(15-6-10-17(11-7-15)24(25)26)14-31(27,28)18-4-2-1-3-5-18/h1-13,22H,14H2,(H2,21,29,30)/b23-20+ ZEPNZOWEOMSUTC-BSYVCWPDSA-N 50378405 CHEMBL4175423 Carbonic anhydrase 4 Homo sapiens 912 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378405&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145952604 160857488 ZINC45258434 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100644 NS(=O)(=O)c1ccc(N\N=C(/CS(=O)(=O)c2ccccc2)c2cc3ccccc3o2)cc1 InChI=1S/C22H19N3O5S2/c23-32(28,29)19-12-10-17(11-13-19)24-25-20(15-31(26,27)18-7-2-1-3-8-18)22-14-16-6-4-5-9-21(16)30-22/h1-14,24H,15H2,(H2,23,28,29)/b25-20+ JBUSCZNNJOPVFG-LKUDQCMESA-N 50378406 CHEMBL4163687 Carbonic anhydrase 4 Homo sapiens 2888 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378406&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145957546 160857489 ZINC45258944 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100646 Cc1ccc(cc1)S(=O)(=O)C\C(=N/Nc1ccc(cc1)S(N)(=O)=O)c1ccc(Cl)cc1 InChI=1S/C21H20ClN3O4S2/c1-15-2-10-19(11-3-15)30(26,27)14-21(16-4-6-17(22)7-5-16)25-24-18-8-12-20(13-9-18)31(23,28)29/h2-13,24H,14H2,1H3,(H2,23,28,29)/b25-21+ SFWIHNHXPKXHSQ-NJNXFGOHSA-N 50378408 CHEMBL4172408 Carbonic anhydrase 4 Homo sapiens 2009 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378408&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145950755 160857491 ZINC45255698 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100658 Cc1ccc(cc1)S(=O)(=O)C\C(=N/Nc1ccc(cc1)S(N)(=O)=O)c1ccc(Br)cc1 InChI=1S/C21H20BrN3O4S2/c1-15-2-10-19(11-3-15)30(26,27)14-21(16-4-6-17(22)7-5-16)25-24-18-8-12-20(13-9-18)31(23,28)29/h2-13,24H,14H2,1H3,(H2,23,28,29)/b25-21+ RPUAKUQHFSISQO-NJNXFGOHSA-N 50378410 CHEMBL4161768 Carbonic anhydrase 4 Homo sapiens 2296 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378410&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145958940 160857493 ZINC45255023 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100659 Cc1ccc(cc1)C(\CS(=O)(=O)c1ccc(C)cc1)=N\Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C22H23N3O4S2/c1-16-3-7-18(8-4-16)22(15-30(26,27)20-11-5-17(2)6-12-20)25-24-19-9-13-21(14-10-19)31(23,28)29/h3-14,24H,15H2,1-2H3,(H2,23,28,29)/b25-22+ JHHIOUKERYQHKM-YYDJUVGSSA-N 50378409 CHEMBL4170551 Carbonic anhydrase 4 Homo sapiens 2722 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378409&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145956076 160857492 ZINC45256816 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100660 Cc1ccc(cc1)S(=O)(=O)C\C(=N/Nc1ccc(cc1)S(N)(=O)=O)c1ccc(cc1)[N+]([O-])=O InChI=1S/C21H20N4O6S2/c1-15-2-10-19(11-3-15)32(28,29)14-21(16-4-8-18(9-5-16)25(26)27)24-23-17-6-12-20(13-7-17)33(22,30)31/h2-13,23H,14H2,1H3,(H2,22,30,31)/b24-21+ CFKHGWBNSVRIGR-DARPEHSRSA-N 50378407 CHEMBL4162288 Carbonic anhydrase 4 Homo sapiens 795 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378407&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145960207 160857490 ZINC45334412 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100661 Cc1ccc(cc1)S(=O)(=O)C\C(=N/Nc1ccc(cc1)S(N)(=O)=O)c1ccc2ccccc2c1 InChI=1S/C25H23N3O4S2/c1-18-6-12-23(13-7-18)33(29,30)17-25(21-9-8-19-4-2-3-5-20(19)16-21)28-27-22-10-14-24(15-11-22)34(26,31)32/h2-16,27H,17H2,1H3,(H2,26,31,32)/b28-25+ LPRCZSRYHYIVQZ-AZPGRJICSA-N 50378814 CHEMBL4167153 Carbonic anhydrase 4 Homo sapiens 2647 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378814&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145953173 160857897 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100662 Cc1ccc(cc1)S(=O)(=O)C\C(=N/Nc1ccc(cc1)S(N)(=O)=O)c1ccsc1 InChI=1S/C19H19N3O4S3/c1-14-2-6-17(7-3-14)28(23,24)13-19(15-10-11-27-12-15)22-21-16-4-8-18(9-5-16)29(20,25)26/h2-12,21H,13H2,1H3,(H2,20,25,26)/b22-19+ WLUFSTGYINZTIL-ZBJSNUHESA-N 50378882 CHEMBL4160409 Carbonic anhydrase 4 Homo sapiens 839 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378882&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145959409 160857965 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100663 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100706 NS(=O)(=O)c1ccc(N\N=C(/CS(=O)(=O)c2ccccc2)c2ccc(F)cc2)cc1 InChI=1S/C20H18FN3O4S2/c21-16-8-6-15(7-9-16)20(14-29(25,26)18-4-2-1-3-5-18)24-23-17-10-12-19(13-11-17)30(22,27)28/h1-13,23H,14H2,(H2,22,27,28)/b24-20+ LNDYVWRCUDDLKD-HIXSDJFHSA-N 50378906 CHEMBL4169017 Carbonic anhydrase 4 Homo sapiens 1692 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378906&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145955978 160857989 ZINC66113299 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100707 NS(=O)(=O)c1ccc(N\N=C(/CS(=O)(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 InChI=1S/C20H18ClN3O4S2/c21-16-8-6-15(7-9-16)20(14-29(25,26)18-4-2-1-3-5-18)24-23-17-10-12-19(13-11-17)30(22,27)28/h1-13,23H,14H2,(H2,22,27,28)/b24-20+ KKEICQQVQJROGA-HIXSDJFHSA-N 50378907 CHEMBL4161745 Carbonic anhydrase 4 Homo sapiens 2577 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378907&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145957711 160857990 ZINC66112392 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100708 NS(=O)(=O)c1ccc(N\N=C(/CS(=O)(=O)c2ccccc2)c2ccc(Br)cc2)cc1 InChI=1S/C20H18BrN3O4S2/c21-16-8-6-15(7-9-16)20(14-29(25,26)18-4-2-1-3-5-18)24-23-17-10-12-19(13-11-17)30(22,27)28/h1-13,23H,14H2,(H2,22,27,28)/b24-20+ KQXLDCJHTCXEGO-HIXSDJFHSA-N 50378909 CHEMBL4172382 Carbonic anhydrase 4 Homo sapiens 2256 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378909&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949670 160857992 ZINC00000808 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100709 Cc1ccc(cc1)C(\CS(=O)(=O)c1ccccc1)=N\Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C21H21N3O4S2/c1-16-7-9-17(10-8-16)21(15-29(25,26)19-5-3-2-4-6-19)24-23-18-11-13-20(14-12-18)30(22,27)28/h2-14,23H,15H2,1H3,(H2,22,27,28)/b24-21+ DOUZUUJXQJZDQH-DARPEHSRSA-N 50378550 CHEMBL4167551 Carbonic anhydrase 4 Homo sapiens 2814 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378550&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145955929 160857633 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100710 NS(=O)(=O)c1ccc(N\N=C(/CS(=O)(=O)c2ccccc2)c2ccc(cc2)-c2ccccc2)cc1 InChI=1S/C26H23N3O4S2/c27-35(32,33)25-17-15-23(16-18-25)28-29-26(19-34(30,31)24-9-5-2-6-10-24)22-13-11-21(12-14-22)20-7-3-1-4-8-20/h1-18,28H,19H2,(H2,27,32,33)/b29-26+ PYEBRIFMLBGXHB-PBBVDAKRSA-N 50378416 CHEMBL4170925 Carbonic anhydrase 4 Homo sapiens 4167 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378416&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951758 160857499 ZINC14210702 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100711 NS(=O)(=O)c1ccc(N\N=C(/CS(=O)(=O)c2ccccc2)c2ccc3ccccc3c2)cc1 InChI=1S/C24H21N3O4S2/c25-33(30,31)23-14-12-21(13-15-23)26-27-24(17-32(28,29)22-8-2-1-3-9-22)20-11-10-18-6-4-5-7-19(18)16-20/h1-16,26H,17H2,(H2,25,30,31)/b27-24+ IRKJYNCRNKTWOB-SOYKGTTHSA-N 50378415 CHEMBL4166779 Carbonic anhydrase 4 Homo sapiens 3123 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378415&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145954524 160857498 ZINC14210707 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100712 NS(=O)(=O)c1ccc(N\N=C(/CS(=O)(=O)c2ccccc2)c2ccco2)cc1 InChI=1S/C18H17N3O5S2/c19-28(24,25)16-10-8-14(9-11-16)20-21-17(18-7-4-12-26-18)13-27(22,23)15-5-2-1-3-6-15/h1-12,20H,13H2,(H2,19,24,25)/b21-17+ UMMWZPCPUKQVFM-HEHNFIMWSA-N 50378413 CHEMBL4174359 Carbonic anhydrase 4 Homo sapiens 710 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378413&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951902 160857496 ZINC45291751 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100713 Cc1ccc(cc1)S(=O)(=O)C\C(=N/Nc1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C21H21N3O4S2/c1-16-7-11-19(12-8-16)29(25,26)15-21(17-5-3-2-4-6-17)24-23-18-9-13-20(14-10-18)30(22,27)28/h2-14,23H,15H2,1H3,(H2,22,27,28)/b24-21+ QJAPGFVRABWMEX-DARPEHSRSA-N 50378412 CHEMBL4159225 Carbonic anhydrase 4 Homo sapiens 3511 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378412&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145957103 160857495 ZINC45298442 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51100714 Cc1ccc(cc1)S(=O)(=O)C\C(=N/Nc1ccc(cc1)S(N)(=O)=O)c1ccc(F)cc1 InChI=1S/C21H20FN3O4S2/c1-15-2-10-19(11-3-15)30(26,27)14-21(16-4-6-17(22)7-5-16)25-24-18-8-12-20(13-9-18)31(23,28)29/h2-13,24H,14H2,1H3,(H2,23,28,29)/b25-21+ LANXETOTUSCQCK-NJNXFGOHSA-N 50378411 CHEMBL4167133 Carbonic anhydrase 4 Homo sapiens 1350 ChEMBL 10.1016/j.ejmech.2018.04.016 10.7270/Q2MK6GGD 29684705 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378411&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145955914 160857494 ZINC45286881 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099824 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN([C@@H](Cc2ccccc2)C1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C25H26N4O6S2/c26-36(32,33)22-10-6-19(7-11-22)24(30)28-14-15-29(21(17-28)16-18-4-2-1-3-5-18)25(31)20-8-12-23(13-9-20)37(27,34)35/h1-13,21H,14-17H2,(H2,26,32,33)(H2,27,34,35)/t21-/m0/s1 DBQMDBXMFKWIGE-NRFANRHFSA-N 50369749 CHEMBL4161993 Carbonic anhydrase 4 Homo sapiens 139 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369749&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145956491 160848851 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099825 CC(=O)N1CCN(C[C@H]1Cc1ccccc1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C20H23N3O4S/c1-15(24)23-12-11-22(14-18(23)13-16-5-3-2-4-6-16)20(25)17-7-9-19(10-8-17)28(21,26)27/h2-10,18H,11-14H2,1H3,(H2,21,26,27)/t18-/m1/s1 YHSOVHWCSACWJK-GOSISDBHSA-N 50369750 CHEMBL4167883 Carbonic anhydrase 4 Homo sapiens 3.3 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369750&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145955486 160848852 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099826 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(C[C@H]1Cc1ccccc1)C(=O)Cc1ccccc1 InChI=1S/C26H27N3O4S/c27-34(32,33)24-13-11-22(12-14-24)26(31)29-16-15-28(25(30)18-21-9-5-2-6-10-21)19-23(29)17-20-7-3-1-4-8-20/h1-14,23H,15-19H2,(H2,27,32,33)/t23-/m1/s1 IFFWROHSTWSEMR-HSZRJFAPSA-N 50369819 CHEMBL4163666 Carbonic anhydrase 4 Homo sapiens 2.3 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369819&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145962693 160848921 ZINC36221102 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099827 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(Cc2ccccc2)C[C@H]1Cc1ccccc1 InChI=1S/C25H27N3O3S/c26-32(30,31)24-13-11-22(12-14-24)25(29)28-16-15-27(18-21-9-5-2-6-10-21)19-23(28)17-20-7-3-1-4-8-20/h1-14,23H,15-19H2,(H2,26,30,31)/t23-/m1/s1 ZQMJRMGRRHWVKV-HSZRJFAPSA-N 50369824 CHEMBL4171369 Carbonic anhydrase 4 Homo sapiens 67 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369824&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145950033 160848926 ZINC36221105 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099837 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN([C@@H](Cc2ccccc2)C1)C(=O)Cc1ccccc1 InChI=1S/C26H27N3O4S/c27-34(32,33)24-13-11-22(12-14-24)26(31)28-15-16-29(25(30)18-21-9-5-2-6-10-21)23(19-28)17-20-7-3-1-4-8-20/h1-14,23H,15-19H2,(H2,27,32,33)/t23-/m0/s1 YPYXPEXPHVLNMR-QHCPKHFHSA-N 50369877 CHEMBL4163090 Carbonic anhydrase 4 Homo sapiens 371 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369877&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145960779 160848979 ZINC49018858 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099842 CS(=O)(=O)N1CCN(C[C@@H]1Cc1ccccc1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H23N3O5S2/c1-28(24,25)22-12-11-21(14-17(22)13-15-5-3-2-4-6-15)19(23)16-7-9-18(10-8-16)29(20,26)27/h2-10,17H,11-14H2,1H3,(H2,20,26,27)/t17-/m0/s1 NWVUYWNPEZVRNH-KRWDZBQOSA-N 50369880 CHEMBL4165548 Carbonic anhydrase 4 Homo sapiens 80 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145954697 160848982 ZINC49018484 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099851 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN([C@H](Cc2ccccc2)C1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C25H26N4O6S2/c26-36(32,33)22-10-6-19(7-11-22)24(30)28-14-15-29(21(17-28)16-18-4-2-1-3-5-18)25(31)20-8-12-23(13-9-20)37(27,34)35/h1-13,21H,14-17H2,(H2,26,32,33)(H2,27,34,35)/t21-/m1/s1 DBQMDBXMFKWIGE-OAQYLSRUSA-N 50369886 CHEMBL4169920 Carbonic anhydrase 4 Homo sapiens 5.1 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369886&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145953285 160848988 ZINC49792968 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099852 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN([C@H](Cc2ccccc2)C1)C(=O)Cc1ccccc1 InChI=1S/C26H27N3O4S/c27-34(32,33)24-13-11-22(12-14-24)26(31)28-15-16-29(25(30)18-21-9-5-2-6-10-21)23(19-28)17-20-7-3-1-4-8-20/h1-14,23H,15-19H2,(H2,27,32,33)/t23-/m1/s1 YPYXPEXPHVLNMR-HSZRJFAPSA-N 50369825 CHEMBL4171305 Carbonic anhydrase 4 Homo sapiens 2.6 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369825&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949184 160848927 ZINC36221099 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099853 CC(=O)N1CCN(C[C@@H]1Cc1ccccc1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C20H23N3O4S/c1-15(24)23-12-11-22(14-18(23)13-16-5-3-2-4-6-16)20(25)17-7-9-19(10-8-17)28(21,26)27/h2-10,18H,11-14H2,1H3,(H2,21,26,27)/t18-/m0/s1 YHSOVHWCSACWJK-SFHVURJKSA-N 50369887 CHEMBL4166970 Carbonic anhydrase 4 Homo sapiens 67 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369887&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BZW 6EVR 134158397 160848989 ZINC49774368 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099854 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN[C@@H](Cc2ccccc2)C1 InChI=1S/C18H21N3O3S/c19-25(23,24)17-8-6-15(7-9-17)18(22)21-11-10-20-16(13-21)12-14-4-2-1-3-5-14/h1-9,16,20H,10-13H2,(H2,19,23,24)/t16-/m0/s1 PUFUKRGYJIGJDK-INIZCTEOSA-N 50369829 CHEMBL4171303 Carbonic anhydrase 4 Homo sapiens 29 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369829&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949182 160848931 ZINC27561256 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099855 CS(=O)(=O)N1CCN([C@H](Cc2ccccc2)C1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H23N3O5S2/c1-28(24,25)21-11-12-22(17(14-21)13-15-5-3-2-4-6-15)19(23)16-7-9-18(10-8-16)29(20,26)27/h2-10,17H,11-14H2,1H3,(H2,20,26,27)/t17-/m1/s1 DWFOJNYGEYNYIL-QGZVFWFLSA-N 50369884 CHEMBL4172413 Carbonic anhydrase 4 Homo sapiens 2.0 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369884&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145950965 160848986 ZINC49785428 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099856 CC(=O)N1CCN([C@@H](Cc2ccccc2)C1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C20H23N3O4S/c1-15(24)22-11-12-23(18(14-22)13-16-5-3-2-4-6-16)20(25)17-7-9-19(10-8-17)28(21,26)27/h2-10,18H,11-14H2,1H3,(H2,21,26,27)/t18-/m0/s1 BARCLVRRHIHSHU-SFHVURJKSA-N 50369872 CHEMBL4169677 Carbonic anhydrase 4 Homo sapiens 6.0 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369872&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145954868 160848974 ZINC49785394 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099857 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCNC[C@@H]1Cc1ccccc1 InChI=1S/C18H21N3O3S/c19-25(23,24)17-8-6-15(7-9-17)18(22)21-11-10-20-13-16(21)12-14-4-2-1-3-5-14/h1-9,16,20H,10-13H2,(H2,19,23,24)/t16-/m0/s1 GRIQMCZUTORETQ-INIZCTEOSA-N 50369888 CHEMBL4176465 Carbonic anhydrase 4 Homo sapiens 75 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369888&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145972912 160848990 ZINC49771661 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099886 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099887 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN([C@H](Cc2ccccc2)C1)S(=O)(=O)c1ccccc1 InChI=1S/C24H25N3O5S2/c25-33(29,30)22-13-11-20(12-14-22)24(28)26-15-16-27(34(31,32)23-9-5-2-6-10-23)21(18-26)17-19-7-3-1-4-8-19/h1-14,21H,15-18H2,(H2,25,29,30)/t21-/m1/s1 WOAWVWOFNRISDY-OAQYLSRUSA-N 50369873 CHEMBL4172778 Carbonic anhydrase 4 Homo sapiens 8.7 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369873&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951819 160848975 ZINC49031630 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099888 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN([C@@H](Cc2ccccc2)C1)S(=O)(=O)c1ccccc1 InChI=1S/C24H25N3O5S2/c25-33(29,30)22-13-11-20(12-14-22)24(28)26-15-16-27(34(31,32)23-9-5-2-6-10-23)21(18-26)17-19-7-3-1-4-8-19/h1-14,21H,15-18H2,(H2,25,29,30)/t21-/m0/s1 WOAWVWOFNRISDY-NRFANRHFSA-N 50369881 CHEMBL4162104 Carbonic anhydrase 4 Homo sapiens 62 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369881&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145961010 160848983 ZINC49018853 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099889 CS(=O)(=O)N1CCN(C[C@H]1Cc1ccccc1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H23N3O5S2/c1-28(24,25)22-12-11-21(14-17(22)13-15-5-3-2-4-6-15)19(23)16-7-9-18(10-8-16)29(20,26)27/h2-10,17H,11-14H2,1H3,(H2,20,26,27)/t17-/m1/s1 NWVUYWNPEZVRNH-QGZVFWFLSA-N 50369729 CHEMBL4176156 Carbonic anhydrase 4 Homo sapiens 19 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369729&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145972192 160848831 ZINC49793680 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099890 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN([C@H](Cc2ccccc2)C1)C(=O)c1ccccc1 InChI=1S/C25H25N3O4S/c26-33(31,32)23-13-11-21(12-14-23)24(29)27-15-16-28(25(30)20-9-5-2-6-10-20)22(18-27)17-19-7-3-1-4-8-19/h1-14,22H,15-18H2,(H2,26,31,32)/t22-/m1/s1 IVMDIDRARXJLRE-JOCHJYFZSA-N 50369889 CHEMBL4164457 Carbonic anhydrase 4 Homo sapiens 4.0 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369889&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145958803 160848991 ZINC49109889 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099891 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN([C@@H](Cc2ccccc2)C1)C(=O)c1ccccc1 InChI=1S/C25H25N3O4S/c26-33(31,32)23-13-11-21(12-14-23)24(29)27-15-16-28(25(30)20-9-5-2-6-10-20)22(18-27)17-19-7-3-1-4-8-19/h1-14,22H,15-18H2,(H2,26,31,32)/t22-/m0/s1 IVMDIDRARXJLRE-QFIPXVFZSA-N 50369882 CHEMBL4172337 Carbonic anhydrase 4 Homo sapiens 68 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369882&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951380 160848984 ZINC49110935 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099892 CN1CCN(C[C@H]1Cc1ccccc1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H23N3O3S/c1-21-11-12-22(14-17(21)13-15-5-3-2-4-6-15)19(23)16-7-9-18(10-8-16)26(20,24)25/h2-10,17H,11-14H2,1H3,(H2,20,24,25)/t17-/m1/s1 NNDPMPAUZZKJMK-QGZVFWFLSA-N 50369931 CHEMBL4167555 Carbonic anhydrase 4 Homo sapiens 1.7 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369931&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145956169 160849033 ZINC49785750 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099893 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(Cc2ccccc2)[C@H](Cc2ccccc2)C1 InChI=1S/C25H27N3O3S/c26-32(30,31)24-13-11-22(12-14-24)25(29)28-16-15-27(18-21-9-5-2-6-10-21)23(19-28)17-20-7-3-1-4-8-20/h1-14,23H,15-19H2,(H2,26,30,31)/t23-/m1/s1 IUXSJCVNRIERFU-HSZRJFAPSA-N 50369730 CHEMBL4164109 Carbonic anhydrase 4 Homo sapiens 2.3 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369730&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145960039 160848832 ZINC49018558 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099894 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN[C@H](Cc2ccccc2)C1 InChI=1S/C18H21N3O3S/c19-25(23,24)17-8-6-15(7-9-17)18(22)21-11-10-20-16(13-21)12-14-4-2-1-3-5-14/h1-9,16,20H,10-13H2,(H2,19,23,24)/t16-/m1/s1 PUFUKRGYJIGJDK-MRXNPFEDSA-N 50369883 CHEMBL4160707 Carbonic anhydrase 4 Homo sapiens 4.6 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369883&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search N19 6EX1 134817795 160848985 ZINC49031499 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099895 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(C[C@H]1Cc1ccccc1)S(=O)(=O)c1ccccc1 InChI=1S/C24H25N3O5S2/c25-33(29,30)22-13-11-20(12-14-22)24(28)27-16-15-26(34(31,32)23-9-5-2-6-10-23)18-21(27)17-19-7-3-1-4-8-19/h1-14,21H,15-18H2,(H2,25,29,30)/t21-/m1/s1 SUABTRANGSWJMA-OAQYLSRUSA-N 50369934 CHEMBL4175825 Carbonic anhydrase 4 Homo sapiens 3.6 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369934&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145976207 160849036 ZINC49032357 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099896 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(C[C@@H]1Cc1ccccc1)S(=O)(=O)c1ccccc1 InChI=1S/C24H25N3O5S2/c25-33(29,30)22-13-11-20(12-14-22)24(28)27-16-15-26(34(31,32)23-9-5-2-6-10-23)18-21(27)17-19-7-3-1-4-8-19/h1-14,21H,15-18H2,(H2,25,29,30)/t21-/m0/s1 SUABTRANGSWJMA-NRFANRHFSA-N 50369927 CHEMBL4167967 Carbonic anhydrase 4 Homo sapiens 7.8 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369927&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145955720 160849029 ZINC49021195 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099897 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(C[C@H]1Cc1ccccc1)C(=O)c1ccccc1 InChI=1S/C25H25N3O4S/c26-33(31,32)23-13-11-21(12-14-23)25(30)28-16-15-27(24(29)20-9-5-2-6-10-20)18-22(28)17-19-7-3-1-4-8-19/h1-14,22H,15-18H2,(H2,26,31,32)/t22-/m1/s1 WNIHUASJDPZNNX-JOCHJYFZSA-N 50369956 CHEMBL4165182 Carbonic anhydrase 4 Homo sapiens 133 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369956&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145962071 160849058 ZINC38321402 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099898 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(C[C@@H]1Cc1ccccc1)C(=O)c1ccccc1 InChI=1S/C25H25N3O4S/c26-33(31,32)23-13-11-21(12-14-23)25(30)28-16-15-27(24(29)20-9-5-2-6-10-20)18-22(28)17-19-7-3-1-4-8-19/h1-14,22H,15-18H2,(H2,26,31,32)/t22-/m0/s1 WNIHUASJDPZNNX-QFIPXVFZSA-N 50369885 CHEMBL4173083 Carbonic anhydrase 4 Homo sapiens 7.8 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369885&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145950124 160848987 ZINC49031773 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099899 CC(=O)N1CCN([C@H](Cc2ccccc2)C1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C20H23N3O4S/c1-15(24)22-11-12-23(18(14-22)13-16-5-3-2-4-6-16)20(25)17-7-9-19(10-8-17)28(21,26)27/h2-10,18H,11-14H2,1H3,(H2,21,26,27)/t18-/m1/s1 BARCLVRRHIHSHU-GOSISDBHSA-N 50369731 CHEMBL4161747 Carbonic anhydrase 4 Homo sapiens 2.9 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369731&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145957959 160848833 ZINC49089935 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099900 CN1CCN([C@H](Cc2ccccc2)C1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H23N3O3S/c1-21-11-12-22(17(14-21)13-15-5-3-2-4-6-15)19(23)16-7-9-18(10-8-16)26(20,24)25/h2-10,17H,11-14H2,1H3,(H2,20,24,25)/t17-/m1/s1 JJZIVRAYCISPKI-QGZVFWFLSA-N 50369986 CHEMBL4171956 Carbonic anhydrase 4 Homo sapiens 3.6 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369986&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949650 160849088 ZINC49017080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099901 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCNC[C@H]1Cc1ccccc1 InChI=1S/C18H21N3O3S/c19-25(23,24)17-8-6-15(7-9-17)18(22)21-11-10-20-13-16(21)12-14-4-2-1-3-5-14/h1-9,16,20H,10-13H2,(H2,19,23,24)/t16-/m1/s1 GRIQMCZUTORETQ-MRXNPFEDSA-N 50369879 CHEMBL4168600 Carbonic anhydrase 4 Homo sapiens 5.6 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369879&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search K1W 6RG3 145952794 160848981 ZINC49775038 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099902 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(Cc2ccccc2)C[C@@H]1Cc1ccccc1 InChI=1S/C25H27N3O3S/c26-32(30,31)24-13-11-22(12-14-24)25(29)28-16-15-27(18-21-9-5-2-6-10-21)19-23(28)17-20-7-3-1-4-8-20/h1-14,23H,15-19H2,(H2,26,30,31)/t23-/m0/s1 ZQMJRMGRRHWVKV-QHCPKHFHSA-N 50370049 CHEMBL4163470 Carbonic anhydrase 4 Homo sapiens 79 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370049&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145956563 160849151 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099938 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(Cc2ccccc2)[C@@H](Cc2ccccc2)C1 InChI=1S/C25H27N3O3S/c26-32(30,31)24-13-11-22(12-14-24)25(29)28-16-15-27(18-21-9-5-2-6-10-21)23(19-28)17-20-7-3-1-4-8-20/h1-14,23H,15-19H2,(H2,26,30,31)/t23-/m0/s1 IUXSJCVNRIERFU-QHCPKHFHSA-N 50369878 CHEMBL4174759 Carbonic anhydrase 4 Homo sapiens 73 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369878&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951685 160848980 ZINC49019664 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099945 CN1CCN(C[C@@H]1Cc1ccccc1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H23N3O3S/c1-21-11-12-22(14-17(21)13-15-5-3-2-4-6-15)19(23)16-7-9-18(10-8-16)26(20,24)25/h2-10,17H,11-14H2,1H3,(H2,20,24,25)/t17-/m0/s1 NNDPMPAUZZKJMK-KRWDZBQOSA-N 50369874 CHEMBL4159634 Carbonic anhydrase 4 Homo sapiens 146 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369874&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search K45 6RG4 145959374 160848976 ZINC49019668 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099946 CS(=O)(=O)N1CCN([C@@H](Cc2ccccc2)C1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H23N3O5S2/c1-28(24,25)21-11-12-22(17(14-21)13-15-5-3-2-4-6-15)19(23)16-7-9-18(10-8-16)29(20,26)27/h2-10,17H,11-14H2,1H3,(H2,20,26,27)/t17-/m0/s1 DWFOJNYGEYNYIL-KRWDZBQOSA-N 50369955 CHEMBL4164534 Carbonic anhydrase 4 Homo sapiens 73 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369955&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145958565 160849057 ZINC64539668 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099947 CN1CCN([C@@H](Cc2ccccc2)C1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H23N3O3S/c1-21-11-12-22(17(14-21)13-15-5-3-2-4-6-15)19(23)16-7-9-18(10-8-16)26(20,24)25/h2-10,17H,11-14H2,1H3,(H2,20,24,25)/t17-/m0/s1 JJZIVRAYCISPKI-KRWDZBQOSA-N 50369876 CHEMBL4161360 Carbonic anhydrase 4 Homo sapiens 343 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369876&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145957461 160848978 ZINC49109568 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51099959 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(C[C@@H]1Cc1ccccc1)C(=O)Cc1ccccc1 InChI=1S/C26H27N3O4S/c27-34(32,33)24-13-11-22(12-14-24)26(31)29-16-15-28(25(30)18-21-9-5-2-6-10-21)19-23(29)17-20-7-3-1-4-8-20/h1-14,23H,15-19H2,(H2,27,32,33)/t23-/m0/s1 IFFWROHSTWSEMR-QHCPKHFHSA-N 50369875 CHEMBL4171554 Carbonic anhydrase 4 Homo sapiens 5.4 ChEMBL 10.1016/j.ejmech.2018.04.002 10.7270/Q25H7JTC 29635168 Chiaramonte, N; Bua, S; Ferraroni, M; Nocentini, A; Bonardi, A; Bartolucci, G; Durante, M; Lucarini, L; Chiapponi, D; Dei, S; Manetti, D; Teodori, E; Gratteri, P; Masini, E; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50369875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50369875&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949836 160848977 ZINC49785047 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103223 NC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C7H6Cl2N2O3S/c8-4-2-5(9)6(15(11,13)14)1-3(4)7(10)12/h1-2H,(H2,10,12)(H2,11,13,14) IPRGYSAYIGOGMN-UHFFFAOYSA-N 50449822 CHEMBL4175740 Carbonic anhydrase 4 Homo sapiens 1.2 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449822&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12698190 433919385 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103224 CCCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C11H14Cl2N2O3S/c1-2-3-4-15-11(16)7-5-10(19(14,17)18)9(13)6-8(7)12/h5-6H,2-4H2,1H3,(H,15,16)(H2,14,17,18) KRIUYRKSVUBELV-UHFFFAOYSA-N 50449816 CHEMBL4160149 Carbonic anhydrase 4 Homo sapiens 0.420000 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449816&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ENN 6G5U,6G6T 34852311 433919379 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103225 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(Cl)cc1Cl InChI=1S/C13H16Cl2N2O3S/c14-10-7-11(15)12(21(16,19)20)6-9(10)13(18)17-8-4-2-1-3-5-8/h6-8H,1-5H2,(H,17,18)(H2,16,19,20) FYPYZSIHTPQQDJ-UHFFFAOYSA-N 50449834 CHEMBL4173501 Carbonic anhydrase 4 Homo sapiens 0.740000 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449834&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 60635034 433919396 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103226 CCCCNC(=O)c1cc(c(Br)cc1Br)S(N)(=O)=O InChI=1S/C11H14Br2N2O3S/c1-2-3-4-15-11(16)7-5-10(19(14,17)18)9(13)6-8(7)12/h5-6H,2-4H2,1H3,(H,15,16)(H2,14,17,18) QKIXSEIIKHMOKR-UHFFFAOYSA-N 50449836 CHEMBL4166643 Carbonic anhydrase 4 Homo sapiens 0.180000 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449836&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509349 433919398 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103260 NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl InChI=1S/C7H5Cl2NO4S/c8-4-2-5(9)6(15(10,13)14)1-3(4)7(11)12/h1-2H,(H,11,12)(H2,10,13,14) ZSHHRBYVHTVRFK-UHFFFAOYSA-N 13075 2,4-dichloro-5-sulfamoylbenzoic acid::2000-01951::Lasamide (Hsba)::LeadQuest Compound 9 Carbonic anhydrase 4 Homo sapiens 1.3 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13075&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 17655 46513492 ZINC01088182 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103261 CCCCNC(=O)c1cc(c(Br)cc1NC1CCCCC1)S(N)(=O)=O InChI=1S/C17H26BrN3O3S/c1-2-3-9-20-17(22)13-10-16(25(19,23)24)14(18)11-15(13)21-12-7-5-4-6-8-12/h10-12,21H,2-9H2,1H3,(H,20,22)(H2,19,23,24) ALNLRWSQPFMDQS-UHFFFAOYSA-N 50449820 CHEMBL4177268 Carbonic anhydrase 4 Homo sapiens 2.2 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449820&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507636 433919383 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103262 CC(=O)OCCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C12H14Cl2N2O5S/c1-7(17)21-4-2-3-16-12(18)8-5-11(22(15,19)20)10(14)6-9(8)13/h5-6H,2-4H2,1H3,(H,16,18)(H2,15,19,20) ZYZYGWWRCWBUMZ-UHFFFAOYSA-N 50449810 CHEMBL4162133 Carbonic anhydrase 4 Homo sapiens 0.260000 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449810&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507183 433919373 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103263 NS(=O)(=O)c1cc(C(=O)NCCCC(O)=O)c(Cl)cc1Cl InChI=1S/C11H12Cl2N2O5S/c12-7-5-8(13)9(21(14,19)20)4-6(7)11(18)15-3-1-2-10(16)17/h4-5H,1-3H2,(H,15,18)(H,16,17)(H2,14,19,20) AZHHAHHRNOQVSO-UHFFFAOYSA-N 50449821 CHEMBL4168586 Carbonic anhydrase 4 Homo sapiens 1.1 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449821&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508712 433919384 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103283 NS(=O)(=O)c1cc(C(O)=O)c(NC2CCCCCCC2)cc1Cl InChI=1S/C15H21ClN2O4S/c16-12-9-13(18-10-6-4-2-1-3-5-7-10)11(15(19)20)8-14(12)23(17,21)22/h8-10,18H,1-7H2,(H,19,20)(H2,17,21,22) IBXZMQXWKGWYDC-UHFFFAOYSA-N 50449825 CHEMBL4160627 Carbonic anhydrase 4 Homo sapiens 0.380000 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449825&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145956924 433919387 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103284 NS(=O)(=O)c1cc(C(O)=O)c(Br)cc1Br InChI=1S/C7H5Br2NO4S/c8-4-2-5(9)6(15(10,13)14)1-3(4)7(11)12/h1-2H,(H,11,12)(H2,10,13,14) NJWAUKHMSHZTLQ-UHFFFAOYSA-N 50449811 CHEMBL4165127 Carbonic anhydrase 4 Homo sapiens 1.7 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449811&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507856 433919374 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103285 NS(=O)(=O)c1cc(C(=O)NCCO)c(Cl)cc1Cl InChI=1S/C9H10Cl2N2O4S/c10-6-4-7(11)8(18(12,16)17)3-5(6)9(15)13-1-2-14/h3-4,14H,1-2H2,(H,13,15)(H2,12,16,17) UISZEPPPNAJTCZ-UHFFFAOYSA-N 50449831 CHEMBL4172331 Carbonic anhydrase 4 Homo sapiens 1.8 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449831&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12698192 433919393 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103286 NS(=O)(=O)c1cc(C(=O)NCCCO)c(Cl)cc1Cl InChI=1S/C10H12Cl2N2O4S/c11-7-5-8(12)9(19(13,17)18)4-6(7)10(16)14-2-1-3-15/h4-5,15H,1-3H2,(H,14,16)(H2,13,17,18) OZBGWVAREHIEDY-UHFFFAOYSA-N 50449827 CHEMBL4173471 Carbonic anhydrase 4 Homo sapiens 0.032000 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449827&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508709 433919389 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103287 COCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C10H12Cl2N2O4S/c1-18-3-2-14-10(15)6-4-9(19(13,16)17)8(12)5-7(6)11/h4-5H,2-3H2,1H3,(H,14,15)(H2,13,16,17) WVMBHAOCSXODMK-UHFFFAOYSA-N 50449829 CHEMBL4166964 Carbonic anhydrase 4 Homo sapiens 0.050000 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449829&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 21189414 433919391 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103288 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C12H14Cl2N2O5S/c1-21-11(17)3-2-4-16-12(18)7-5-10(22(15,19)20)9(14)6-8(7)13/h5-6H,2-4H2,1H3,(H,16,18)(H2,15,19,20) HPOYDHZZGCZYRF-UHFFFAOYSA-N 50449818 CHEMBL4165896 Carbonic anhydrase 4 Homo sapiens 0.550000 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449818&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508879 433919381 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103289 NS(=O)(=O)c1cc(C(=O)N2CCOCC2)c(Cl)cc1Cl InChI=1S/C11H12Cl2N2O4S/c12-8-6-9(13)10(20(14,17)18)5-7(8)11(16)15-1-3-19-4-2-15/h5-6H,1-4H2,(H2,14,17,18) AVTRWXCLWDQMCF-UHFFFAOYSA-N 50449830 CHEMBL4173814 Carbonic anhydrase 4 Homo sapiens 1.7 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449830&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 60635890 433919392 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103290 NS(=O)(=O)c1cc(C(=O)NCc2ccccc2)c(Cl)cc1Cl InChI=1S/C14H12Cl2N2O3S/c15-11-7-12(16)13(22(17,20)21)6-10(11)14(19)18-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,18,19)(H2,17,20,21) RJDMKEUKPUTKRX-UHFFFAOYSA-N 50449819 CHEMBL4165570 Carbonic anhydrase 4 Homo sapiens 0.099000 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449819&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507182 433919382 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51103291 NS(=O)(=O)c1cc(C(=O)NCCO)c(Br)cc1Br InChI=1S/C9H10Br2N2O4S/c10-6-4-7(11)8(18(12,16)17)3-5(6)9(15)13-1-2-14/h3-4,14H,1-2H2,(H,13,15)(H2,12,16,17) FASQQHIRLIBRPZ-UHFFFAOYSA-N 50449809 CHEMBL4168997 Carbonic anhydrase 4 Homo sapiens 0.310000 ChEMBL 10.1016/j.ejmech.2018.06.059 10.7270/Q2805559 30006175 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Kišonaitė, M; Smirnov, A; Manakova, E; Gražulis, S; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449809&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509027 433919372 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102218 NS(=O)(=O)c1ccc(cc1)-n1cc(nn1)C(=O)c1ccccn1 InChI=1S/C14H11N5O3S/c15-23(21,22)11-6-4-10(5-7-11)19-9-13(17-18-19)14(20)12-3-1-2-8-16-12/h1-9H,(H2,15,21,22) JPYUYFYRGAKWHH-UHFFFAOYSA-N 50449620 CHEMBL4176241 Carbonic anhydrase 4 Homo sapiens 389 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449620&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145971458 433919205 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102219 Cc1ccc(cc1)C(=O)c1nnn(c1C(F)(F)F)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C17H13F3N4O3S/c1-10-2-4-11(5-3-10)15(25)14-16(17(18,19)20)24(23-22-14)12-6-8-13(9-7-12)28(21,26)27/h2-9H,1H3,(H2,21,26,27) PBLAWKKTGRCBQY-UHFFFAOYSA-N 50449621 CHEMBL4174907 Carbonic anhydrase 4 Homo sapiens 773 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449621&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951488 433919206 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102220 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(=O)c2ccc(Cl)cc2)c1C(F)(F)F InChI=1S/C16H10ClF3N4O3S/c17-10-3-1-9(2-4-10)14(25)13-15(16(18,19)20)24(23-22-13)11-5-7-12(8-6-11)28(21,26)27/h1-8H,(H2,21,26,27) RNIXLPSZNHWTPF-UHFFFAOYSA-N 50449622 CHEMBL4166517 Carbonic anhydrase 4 Homo sapiens 96 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449622&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145953572 433919207 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102229 NS(=O)(=O)c1ccc(cc1)-n1cc(nn1)C(=O)c1ccc(Cl)cc1 InChI=1S/C15H11ClN4O3S/c16-11-3-1-10(2-4-11)15(21)14-9-20(19-18-14)12-5-7-13(8-6-12)24(17,22)23/h1-9H,(H2,17,22,23) LYKJQWAEPRUUEK-UHFFFAOYSA-N 50449618 CHEMBL4173541 Carbonic anhydrase 4 Homo sapiens 79 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449618&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951214 433919203 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102230 NS(=O)(=O)c1ccc(cc1)-n1cc(nn1)C(=O)c1ccc(F)cc1 InChI=1S/C15H11FN4O3S/c16-11-3-1-10(2-4-11)15(21)14-9-20(19-18-14)12-5-7-13(8-6-12)24(17,22)23/h1-9H,(H2,17,22,23) NAHJNBSRDRMTPD-UHFFFAOYSA-N 50449616 CHEMBL4161577 Carbonic anhydrase 4 Homo sapiens 52 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449616&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145958447 433919201 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102231 COc1ccc(cc1)C(=O)c1cn(nn1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H14N4O4S/c1-24-13-6-2-11(3-7-13)16(21)15-10-20(19-18-15)12-4-8-14(9-5-12)25(17,22)23/h2-10H,1H3,(H2,17,22,23) IEEGOYJBQVMORS-UHFFFAOYSA-N 50449628 CHEMBL4176906 Carbonic anhydrase 4 Homo sapiens 80 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449628&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145971736 433919212 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102232 Cc1ccc(cc1)C(=O)c1cn(nn1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H14N4O3S/c1-11-2-4-12(5-3-11)16(21)15-10-20(19-18-15)13-6-8-14(9-7-13)24(17,22)23/h2-10H,1H3,(H2,17,22,23) UBSAHHSNQXOAAL-UHFFFAOYSA-N 50449619 CHEMBL4169044 Carbonic anhydrase 4 Homo sapiens 85 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449619&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145953466 433919204 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102233 NS(=O)(=O)c1ccc(cc1)-n1cc(nn1)C(=O)c1ccccc1 InChI=1S/C15H12N4O3S/c16-23(21,22)13-8-6-12(7-9-13)19-10-14(17-18-19)15(20)11-4-2-1-3-5-11/h1-10H,(H2,16,21,22) BHZFXBHXTCMTTN-UHFFFAOYSA-N 50449629 CHEMBL4169712 Carbonic anhydrase 4 Homo sapiens 914 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449629&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145952834 433919213 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102254 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(=O)c2ccccn2)c1C(F)(F)F InChI=1S/C15H10F3N5O3S/c16-15(17,18)14-12(13(24)11-3-1-2-8-20-11)21-22-23(14)9-4-6-10(7-5-9)27(19,25)26/h1-8H,(H2,19,25,26) PPFNNWYGIUACKO-UHFFFAOYSA-N 50449617 CHEMBL4172989 Carbonic anhydrase 4 Homo sapiens 295 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449617&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949909 433919202 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102255 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(=O)c2cccs2)c1C(F)(F)F InChI=1S/C18H21ClN4O/c19-14-9-13(17-12(16(14)20)4-1-6-21-17)18(24)22-15-5-8-23-7-2-3-11(15)10-23/h1,4,6,9,11,15H,2-3,5,7-8,10,20H2,(H,22,24) ZXTPPBDZBKAHMV-UHFFFAOYSA-N 50449631 CHEMBL4175057 Carbonic anhydrase 4 Homo sapiens 556 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449631&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951698 225144980 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102256 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(=O)c2ccco2)c1C(F)(F)F InChI=1S/C14H9F3N4O4S/c15-14(16,17)13-11(12(22)10-2-1-7-25-10)19-20-21(13)8-3-5-9(6-4-8)26(18,23)24/h1-7H,(H2,18,23,24) NOVCYCXTDLVEFS-UHFFFAOYSA-N 50449630 CHEMBL4172742 Carbonic anhydrase 4 Homo sapiens 618 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449630&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145950340 433919214 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102257 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102274 NS(=O)(=O)c1ccc(cc1)-n1cc(nn1)C(=O)c1ccc(Br)cc1 InChI=1S/C15H18ClN5OS/c16-10-6-9(13-14(12(10)17)20-23-19-13)15(22)18-11-3-5-21-4-1-2-8(11)7-21/h6,8,11H,1-5,7,17H2,(H,18,22) UMHNYWDDWJWNHJ-UHFFFAOYSA-N 50449633 CHEMBL4159655 Carbonic anhydrase 4 Homo sapiens 326 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449633&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145956363 225144982 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102275 NS(=O)(=O)c1ccc(cc1)-n1cc(nn1)C(=O)c1ccc2ccccc2c1 InChI=1S/C19H14N4O3S/c20-27(25,26)17-9-7-16(8-10-17)23-12-18(21-22-23)19(24)15-6-5-13-3-1-2-4-14(13)11-15/h1-12H,(H2,20,25,26) KKGOTVIAKMVULU-UHFFFAOYSA-N 50449615 CHEMBL4169969 Carbonic anhydrase 4 Homo sapiens 370 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449615&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145955576 433919200 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102276 NS(=O)(=O)c1ccc(cc1)-n1cc(nn1)C(=O)c1cccs1 InChI=1S/C14H16ClN5OS/c15-9-5-8(12-13(11(9)16)19-22-18-12)14(21)17-10-6-20-3-1-7(10)2-4-20/h5,7,10H,1-4,6,16H2,(H,17,21) DNQOMGGYJRBLOX-UHFFFAOYSA-N 50449632 CHEMBL4166674 Carbonic anhydrase 4 Homo sapiens 419 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449632&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145954740 225144981 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102277 NS(=O)(=O)c1ccc(cc1)-n1cc(nn1)C(=O)c1ccco1 InChI=1S/C13H10N4O4S/c14-22(19,20)10-5-3-9(4-6-10)17-8-11(15-16-17)13(18)12-2-1-7-21-12/h1-8H,(H2,14,19,20) OCEBKVSIGPPSFW-UHFFFAOYSA-N 50449626 CHEMBL4173947 Carbonic anhydrase 4 Homo sapiens 341 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449626&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949743 433919211 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102278 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(=O)c2ccccc2)c1C(F)(F)F InChI=1S/C16H11F3N4O3S/c17-16(18,19)15-13(14(24)10-4-2-1-3-5-10)21-22-23(15)11-6-8-12(9-7-11)27(20,25)26/h1-9H,(H2,20,25,26) AUTAZJSVHVHZSN-UHFFFAOYSA-N 50449614 CHEMBL4163229 Carbonic anhydrase 4 Homo sapiens 919 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449614&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145958994 433919199 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102279 COc1ccc(cc1)C(=O)c1nnn(c1C(F)(F)F)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C17H13F3N4O4S/c1-28-12-6-2-10(3-7-12)15(25)14-16(17(18,19)20)24(23-22-14)11-4-8-13(9-5-11)29(21,26)27/h2-9H,1H3,(H2,21,26,27) LTRHBQHEFVAWDV-UHFFFAOYSA-N 50449625 CHEMBL4159931 Carbonic anhydrase 4 Homo sapiens 242 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449625&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145959635 433919210 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102280 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(=O)c2ccc(F)cc2)c1C(F)(F)F InChI=1S/C16H10F4N4O3S/c17-10-3-1-9(2-4-10)14(25)13-15(16(18,19)20)24(23-22-13)11-5-7-12(8-6-11)28(21,26)27/h1-8H,(H2,21,26,27) UMKDVAXPKOOUDE-UHFFFAOYSA-N 50449613 CHEMBL4176809 Carbonic anhydrase 4 Homo sapiens 82 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449613&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145971486 433919198 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102281 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(=O)c2ccc(Br)cc2)c1C(F)(F)F InChI=1S/C16H10BrF3N4O3S/c17-10-3-1-9(2-4-10)14(25)13-15(16(18,19)20)24(23-22-13)11-5-7-12(8-6-11)28(21,26)27/h1-8H,(H2,21,26,27) JUDVOHVAPWAVFV-UHFFFAOYSA-N 50449624 CHEMBL4171045 Carbonic anhydrase 4 Homo sapiens 88 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449624&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145949806 433919209 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51102282 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(=O)c2ccc3ccccc3c2)c1C(F)(F)F InChI=1S/C20H13F3N4O3S/c21-20(22,23)19-17(18(28)14-6-5-12-3-1-2-4-13(12)11-14)25-26-27(19)15-7-9-16(10-8-15)31(24,29)30/h1-11H,(H2,24,29,30) RZVJOWTWCDOOAH-UHFFFAOYSA-N 50449623 CHEMBL4160760 Carbonic anhydrase 4 Homo sapiens 321 ChEMBL 10.1016/j.ejmech.2018.06.021 10.7270/Q2SX6GSF 29909339 Kumar, R; Vats, L; Bua, S; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449623&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145957430 433919208 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51097348 NS(=O)(=O)c1ccc(cc1)-n1ncc2c1CCCC2=O InChI=1S/C13H13N3O3S/c14-20(18,19)10-6-4-9(5-7-10)16-12-2-1-3-13(17)11(12)8-15-16/h4-8H,1-3H2,(H2,14,18,19) OSAREFJMAAXDHV-UHFFFAOYSA-N 50341397 CHEMBL4176953 Carbonic anhydrase 4 Homo sapiens 9.5 ChEMBL 10.1021/acs.jmedchem.8b00670 10.7270/Q2DB84F9 29912561 Salerno, S; Barresi, E; Amendola, G; Berrino, E; Milite, C; Marini, AM; Da Settimo, F; Novellino, E; Supuran, CT; Cosconati, S; Taliani, S Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341397&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145974101 131344333 ZINC71329039 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51097352 Cc1ncc2-c3c(CCc2n1)cnn3-c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H15N5O2S/c1-10-18-9-14-15(20-10)7-2-11-8-19-21(16(11)14)12-3-5-13(6-4-12)24(17,22)23/h3-6,8-9H,2,7H2,1H3,(H2,17,22,23) MQDSVUVQHHLGMB-UHFFFAOYSA-N 50341399 CHEMBL4159913 Carbonic anhydrase 4 Homo sapiens 581 ChEMBL 10.1021/acs.jmedchem.8b00670 10.7270/Q2DB84F9 29912561 Salerno, S; Barresi, E; Amendola, G; Berrino, E; Milite, C; Marini, AM; Da Settimo, F; Novellino, E; Supuran, CT; Cosconati, S; Taliani, S Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341399&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145959116 131344335 ZINC18152143 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51097353 CC1(C)CC(=O)c2cnc(Nc3ccc(cc3)S(N)(=O)=O)nc2C1 InChI=1S/C16H18N4O3S/c1-16(2)7-13-12(14(21)8-16)9-18-15(20-13)19-10-3-5-11(6-4-10)24(17,22)23/h3-6,9H,7-8H2,1-2H3,(H2,17,22,23)(H,18,19,20) ONSFYFQHGOOTMW-UHFFFAOYSA-N 50341400 CHEMBL4161917 Carbonic anhydrase 4 Homo sapiens 319 ChEMBL 10.1021/acs.jmedchem.8b00670 10.7270/Q2DB84F9 29912561 Salerno, S; Barresi, E; Amendola, G; Berrino, E; Milite, C; Marini, AM; Da Settimo, F; Novellino, E; Supuran, CT; Cosconati, S; Taliani, S Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341400&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145957236 131344336 ZINC18204267 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51097360 CC1(C)Cc2c(cnn2-c2ccc(cc2)S(N)(=O)=O)C(=O)C1 InChI=1S/C15H17N3O3S/c1-15(2)7-13-12(14(19)8-15)9-17-18(13)10-3-5-11(6-4-10)22(16,20)21/h3-6,9H,7-8H2,1-2H3,(H2,16,20,21) APKGRKWJHXMFDQ-UHFFFAOYSA-N 50341404 CHEMBL4169089 Carbonic anhydrase 4 Homo sapiens 40 ChEMBL 10.1021/acs.jmedchem.8b00670 10.7270/Q2DB84F9 29912561 Salerno, S; Barresi, E; Amendola, G; Berrino, E; Milite, C; Marini, AM; Da Settimo, F; Novellino, E; Supuran, CT; Cosconati, S; Taliani, S Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341404&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145955537 131344340 ZINC71319110 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127293 CCOC(=O)c1nnn(c1-c1ccc(Br)cc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C17H15BrN4O4S/c1-2-26-17(23)15-16(11-3-5-12(18)6-4-11)22(21-20-15)13-7-9-14(10-8-13)27(19,24)25/h3-10H,2H2,1H3,(H2,19,24,25) ZGBUAGSHZXLQFF-UHFFFAOYSA-N 50462251 CHEMBL4248709 Carbonic anhydrase 4 Homo sapiens 53 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462251&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145984095 433929516 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127294 NS(=O)(=O)c1ccc(cc1)-n1nnc(CO)c1-c1ccc(F)cc1 InChI=1S/C15H13FN4O3S/c16-11-3-1-10(2-4-11)15-14(9-21)18-19-20(15)12-5-7-13(8-6-12)24(17,22)23/h1-8,21H,9H2,(H2,17,22,23) WGUVCBLSLVMBON-UHFFFAOYSA-N 50462252 CHEMBL4248681 Carbonic anhydrase 4 Homo sapiens 230 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462252&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145983856 433929517 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127295 NNC(=O)c1nnn(c1-c1cccs1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C13H12N6O3S2/c14-16-13(20)11-12(10-2-1-7-23-10)19(18-17-11)8-3-5-9(6-4-8)24(15,21)22/h1-7H,14H2,(H,16,20)(H2,15,21,22) CDFSUTZDPRORMS-UHFFFAOYSA-N 50462253 CHEMBL4250970 Carbonic anhydrase 4 Homo sapiens 628 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462253&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145984354 433929518 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127310 Cc1ccc(cc1)-c1c(CO)nnn1-c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H16N4O3S/c1-11-2-4-12(5-3-11)16-15(10-21)18-19-20(16)13-6-8-14(9-7-13)24(17,22)23/h2-9,21H,10H2,1H3,(H2,17,22,23) JRTVSDGLVKUAGG-UHFFFAOYSA-N 50462261 CHEMBL4248617 Carbonic anhydrase 4 Homo sapiens 649 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462261&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145983131 433929526 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127311 NC(=O)c1nnn(c1-c1ccc(F)cc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C15H12FN5O3S/c16-10-3-1-9(2-4-10)14-13(15(17)22)19-20-21(14)11-5-7-12(8-6-11)25(18,23)24/h1-8H,(H2,17,22)(H2,18,23,24) GDFRNEXZIDYJEC-UHFFFAOYSA-N 50462256 CHEMBL4247127 Carbonic anhydrase 4 Homo sapiens 229 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462256&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145982622 433929521 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127318 CCOC(=O)c1nnn(c1-c1ccc(F)cc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C17H15FN4O4S/c1-2-26-17(23)15-16(11-3-5-12(18)6-4-11)22(21-20-15)13-7-9-14(10-8-13)27(19,24)25/h3-10H,2H2,1H3,(H2,19,24,25) SISMBOAQIRZVBJ-UHFFFAOYSA-N 50462264 CHEMBL4245748 Carbonic anhydrase 4 Homo sapiens 84 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462264&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145983568 433929529 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127319 CCOC(=O)c1nnn(c1-c1cccs1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C15H14N4O4S2/c1-2-23-15(20)13-14(12-4-3-9-24-12)19(18-17-13)10-5-7-11(8-6-10)25(16,21)22/h3-9H,2H2,1H3,(H2,16,21,22) JWSAKAYOFUWFOJ-UHFFFAOYSA-N 50462265 CHEMBL4238246 Carbonic anhydrase 4 Homo sapiens 2507 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462265&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145985679 433929530 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127320 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(O)=O)c1-c1ccc(Br)cc1 InChI=1S/C15H11BrN4O4S/c16-10-3-1-9(2-4-10)14-13(15(21)22)18-19-20(14)11-5-7-12(8-6-11)25(17,23)24/h1-8H,(H,21,22)(H2,17,23,24) AKSCKRVJNXCNOW-UHFFFAOYSA-N 50462257 CHEMBL4243927 Carbonic anhydrase 4 Homo sapiens 66 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462257&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145983056 433929522 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127321 NS(=O)(=O)c1ccc(cc1)-n1nnc(CO)c1-c1ccccn1 InChI=1S/C14H13N5O3S/c15-23(21,22)11-6-4-10(5-7-11)19-14(13(9-20)17-18-19)12-3-1-2-8-16-12/h1-8,20H,9H2,(H2,15,21,22) WOMJQYGRRPMCKF-UHFFFAOYSA-N 50462266 CHEMBL4238832 Carbonic anhydrase 4 Homo sapiens 1954 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462266&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145986123 433929531 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127322 NNC(=O)c1nnn(c1-c1ccc(F)cc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C15H13FN6O3S/c16-10-3-1-9(2-4-10)14-13(15(23)19-17)20-21-22(14)11-5-7-12(8-6-11)26(18,24)25/h1-8H,17H2,(H,19,23)(H2,18,24,25) GUEYQPYRZAOWQL-UHFFFAOYSA-N 50462258 CHEMBL4244142 Carbonic anhydrase 4 Homo sapiens 273 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462258&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145985969 433929523 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127323 NC(=O)c1nnn(c1-c1ccc(Cl)cc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C15H12ClN5O3S/c16-10-3-1-9(2-4-10)14-13(15(17)22)19-20-21(14)11-5-7-12(8-6-11)25(18,23)24/h1-8H,(H2,17,22)(H2,18,23,24) YJHQHKNXQGUDCG-UHFFFAOYSA-N 50462267 CHEMBL4251418 Carbonic anhydrase 4 Homo sapiens 50 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462267&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145986297 433929532 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127324 NC(=O)c1nnn(c1-c1cccs1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C13H11N5O3S2/c14-13(19)11-12(10-2-1-7-22-10)18(17-16-11)8-3-5-9(6-4-8)23(15,20)21/h1-7H,(H2,14,19)(H2,15,20,21) XSQHOKUBBXFZDB-UHFFFAOYSA-N 50462268 CHEMBL4240831 Carbonic anhydrase 4 Homo sapiens 570 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462268&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145985922 433929533 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127362 CCOC(=O)c1nnn(c1-c1ccc(C)cc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C18H18N4O4S/c1-3-26-18(23)16-17(13-6-4-12(2)5-7-13)22(21-20-16)14-8-10-15(11-9-14)27(19,24)25/h4-11H,3H2,1-2H3,(H2,19,24,25) LMNCDPRRPSWTCG-UHFFFAOYSA-N 50462249 CHEMBL4246204 Carbonic anhydrase 4 Homo sapiens 36 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462249&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145985534 433929514 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127363 CCOC(=O)c1nnn(c1-c1ccc(Cl)cc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C17H15ClN4O4S/c1-2-26-17(23)15-16(11-3-5-12(18)6-4-11)22(21-20-15)13-7-9-14(10-8-13)27(19,24)25/h3-10H,2H2,1H3,(H2,19,24,25) JXWXJNZQTISLCD-UHFFFAOYSA-N 50462244 CHEMBL4246543 Carbonic anhydrase 4 Homo sapiens 44 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462244&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145982836 433929509 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127364 CCOC(=O)c1nnn(c1-c1ccccn1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H15N5O4S/c1-2-25-16(22)14-15(13-5-3-4-10-18-13)21(20-19-14)11-6-8-12(9-7-11)26(17,23)24/h3-10H,2H2,1H3,(H2,17,23,24) SLZSEDNJSHGVKJ-UHFFFAOYSA-N 50462250 CHEMBL4239935 Carbonic anhydrase 4 Homo sapiens 836 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462250&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145985912 433929515 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127365 Cc1ccc(cc1)-c1c(nnn1-c1ccc(cc1)S(N)(=O)=O)C(O)=O InChI=1S/C16H14N4O4S/c1-10-2-4-11(5-3-10)15-14(16(21)22)18-19-20(15)12-6-8-13(9-7-12)25(17,23)24/h2-9H,1H3,(H,21,22)(H2,17,23,24) ZCELAJXJQJOMME-UHFFFAOYSA-N 50462273 CHEMBL4242394 Carbonic anhydrase 4 Homo sapiens 153 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462273&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145985005 433929538 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127366 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(O)=O)c1-c1ccc(F)cc1 InChI=1S/C15H11FN4O4S/c16-10-3-1-9(2-4-10)14-13(15(21)22)18-19-20(14)11-5-7-12(8-6-11)25(17,23)24/h1-8H,(H,21,22)(H2,17,23,24) VPQIROJQPBHBJM-UHFFFAOYSA-N 50462254 CHEMBL4250368 Carbonic anhydrase 4 Homo sapiens 86 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462254&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145984855 433929519 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127367 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(O)=O)c1-c1ccc(Cl)cc1 InChI=1S/C15H11ClN4O4S/c16-10-3-1-9(2-4-10)14-13(15(21)22)18-19-20(14)11-5-7-12(8-6-11)25(17,23)24/h1-8H,(H,21,22)(H2,17,23,24) KFFWKBHCSLXAHB-UHFFFAOYSA-N 50462262 CHEMBL4247007 Carbonic anhydrase 4 Homo sapiens 45 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462262&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145984801 433929527 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127368 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(O)=O)c1-c1ccccn1 InChI=1S/C14H11N5O4S/c15-24(22,23)10-6-4-9(5-7-10)19-13(11-3-1-2-8-16-11)12(14(20)21)17-18-19/h1-8H,(H,20,21)(H2,15,22,23) JGUWBIMENRLPBJ-UHFFFAOYSA-N 50462248 CHEMBL4247158 Carbonic anhydrase 4 Homo sapiens 736 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462248&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145983107 433929513 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127369 NS(=O)(=O)c1ccc(cc1)-n1nnc(CO)c1-c1ccc(Cl)cc1 InChI=1S/C15H13ClN4O3S/c16-11-3-1-10(2-4-11)15-14(9-21)18-19-20(15)12-5-7-13(8-6-12)24(17,22)23/h1-8,21H,9H2,(H2,17,22,23) SCMJXESWOQALRL-UHFFFAOYSA-N 50462272 CHEMBL4250388 Carbonic anhydrase 4 Homo sapiens 88 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462272&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145985353 433929537 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127370 NS(=O)(=O)c1ccc(cc1)-n1nnc(CO)c1-c1ccc(Br)cc1 InChI=1S/C15H13BrN4O3S/c16-11-3-1-10(2-4-11)15-14(9-21)18-19-20(15)12-5-7-13(8-6-12)24(17,22)23/h1-8,21H,9H2,(H2,17,22,23) OVUOSGZYUOOKKS-UHFFFAOYSA-N 50462271 CHEMBL4244032 Carbonic anhydrase 4 Homo sapiens 278 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462271&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145984517 433929536 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127371 NS(=O)(=O)c1ccc(cc1)-n1nnc(CO)c1-c1cccs1 InChI=1S/C13H12N4O3S2/c14-22(19,20)10-5-3-9(4-6-10)17-13(11(8-18)15-16-17)12-2-1-7-21-12/h1-7,18H,8H2,(H2,14,19,20) GGVOHPJUZCDNRF-UHFFFAOYSA-N 50462255 CHEMBL4247010 Carbonic anhydrase 4 Homo sapiens 169 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462255&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145984802 433929520 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127372 Cc1ccc(cc1)-c1c(nnn1-c1ccc(cc1)S(N)(=O)=O)C(=O)NN InChI=1S/C16H16N6O3S/c1-10-2-4-11(5-3-10)15-14(16(23)19-17)20-21-22(15)12-6-8-13(9-7-12)26(18,24)25/h2-9H,17H2,1H3,(H,19,23)(H2,18,24,25) ILJHVRSSHUVGCQ-UHFFFAOYSA-N 50462260 CHEMBL4242770 Carbonic anhydrase 4 Homo sapiens 295 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462260&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145982786 433929525 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127373 NNC(=O)c1nnn(c1-c1ccc(Cl)cc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C15H13ClN6O3S/c16-10-3-1-9(2-4-10)14-13(15(23)19-17)20-21-22(14)11-5-7-12(8-6-11)26(18,24)25/h1-8H,17H2,(H,19,23)(H2,18,24,25) XMAYTKYVFNILOI-UHFFFAOYSA-N 50462247 CHEMBL4248394 Carbonic anhydrase 4 Homo sapiens 50 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462247&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145983850 433929512 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127374 NNC(=O)c1nnn(c1-c1ccc(Br)cc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C15H13BrN6O3S/c16-10-3-1-9(2-4-10)14-13(15(23)19-17)20-21-22(14)11-5-7-12(8-6-11)26(18,24)25/h1-8H,17H2,(H,19,23)(H2,18,24,25) QXQIZKGYNUGQGO-UHFFFAOYSA-N 50462270 CHEMBL4240383 Carbonic anhydrase 4 Homo sapiens 37 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462270&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145984222 433929535 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127375 Cc1ccc(cc1)-c1c(nnn1-c1ccc(cc1)S(N)(=O)=O)C(N)=O InChI=1S/C16H15N5O3S/c1-10-2-4-11(5-3-10)15-14(16(17)22)19-20-21(15)12-6-8-13(9-7-12)25(18,23)24/h2-9H,1H3,(H2,17,22)(H2,18,23,24) AYGFRTJVACTGEO-UHFFFAOYSA-N 50462263 CHEMBL4246936 Carbonic anhydrase 4 Homo sapiens 36 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462263&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145984067 433929528 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127376 NC(=O)c1nnn(c1-c1ccc(Br)cc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C15H12BrN5O3S/c16-10-3-1-9(2-4-10)14-13(15(17)22)19-20-21(14)11-5-7-12(8-6-11)25(18,23)24/h1-8H,(H2,17,22)(H2,18,23,24) MQYKJWPTFKLMTM-UHFFFAOYSA-N 50462259 CHEMBL4243345 Carbonic anhydrase 4 Homo sapiens 79 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462259&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145982576 433929524 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127377 NC(=O)c1nnn(c1-c1ccccn1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C14H12N6O3S/c15-14(21)12-13(11-3-1-2-8-17-11)20(19-18-12)9-4-6-10(7-5-9)24(16,22)23/h1-8H,(H2,15,21)(H2,16,22,23) NZMXRUATQMDSGK-UHFFFAOYSA-N 50462269 CHEMBL4244744 Carbonic anhydrase 4 Homo sapiens 478 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462269&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145985761 433929534 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127399 NS(=O)(=O)c1ccc(cc1)-n1nnc(C(O)=O)c1-c1cccs1 InChI=1S/C13H10N4O4S2/c14-23(20,21)9-5-3-8(4-6-9)17-12(10-2-1-7-22-10)11(13(18)19)15-16-17/h1-7H,(H,18,19)(H2,14,20,21) JCIZOEQFZRVFQP-UHFFFAOYSA-N 50462245 CHEMBL4238069 Carbonic anhydrase 4 Homo sapiens 60 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462245&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145982969 433929510 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127401 NNC(=O)c1nnn(c1-c1ccccn1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C14H13N7O3S/c15-18-14(22)12-13(11-3-1-2-8-17-11)21(20-19-12)9-4-6-10(7-5-9)25(16,23)24/h1-8H,15H2,(H,18,22)(H2,16,23,24) CEMZFTUSEIHJPT-UHFFFAOYSA-N 50462246 CHEMBL4244589 Carbonic anhydrase 4 Homo sapiens 885 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462246&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145983797 433929511 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127402 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2018.03.030 10.7270/Q2T43WR6 29571155 Vats, L; Sharma, V; Angeli, A; Kumar, R; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127743 Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]1O InChI=1S/C10H13ClN6O6S/c11-10-15-7(12)4-8(16-10)17(2-14-4)9-6(19)5(18)3(23-9)1-22-24(13,20)21/h2-3,5-6,9,18-19H,1H2,(H2,12,15,16)(H2,13,20,21)/t3-,5-,6-,9-/m1/s1 JHUGCRSKMUFKHR-UUOKFMHZSA-N 50462455 CHEMBL3250749 Carbonic anhydrase 4 Homo sapiens 234 ChEMBL 10.1016/j.bmcl.2018.04.038 10.7270/Q2VX0K4H 29685656 Mujumdar, P; Bua, S; Supuran, CT; Peat, TS; Poulsen, SA Griffith University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462455&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EO7 6C7X 125623 433929720 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51127747 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]1O InChI=1S/C10H14N6O6S/c11-8-5-9(14-2-13-8)16(3-15-5)10-7(18)6(17)4(22-10)1-21-23(12,19)20/h2-4,6-7,10,17-18H,1H2,(H2,11,13,14)(H2,12,19,20)/t4-,6-,7-,10-/m1/s1 GNZLUJQJDPRUTD-KQYNXXCUSA-N 50454088 5''-O-(Sulfamoyl)Adenosine::5''-O-Sulfamoyladenosine::CHEMBL471144 Carbonic anhydrase 4 Homo sapiens 4450 ChEMBL 10.1016/j.bmcl.2018.04.038 10.7270/Q2VX0K4H 29685656 Mujumdar, P; Bua, S; Supuran, CT; Peat, TS; Poulsen, SA Griffith University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454088&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search LMS 4INJ,1OBH,2V0C,1OBC,6C7W,1H3N,7TGM,4AQ7 97576 225146166 CHEMBL471144 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51156780 NS(=O)(=O)c1cc2C=C(CN3CCOCC3)N(c3cccc(O)c3)S(=O)(=O)c2s1 InChI=1S/C17H19N3O6S3/c18-28(22,23)16-9-12-8-14(11-19-4-6-26-7-5-19)20(29(24,25)17(12)27-16)13-2-1-3-15(21)10-13/h1-3,8-10,21H,4-7,11H2,(H2,18,22,23) PZLYYZPXSSNGJS-UHFFFAOYSA-N 11390 2-(3-Hydroxyphenyl)-3-(4-morpholinylmethyl)-2H-thieno-[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide::2-(3-hydroxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::AL-6619::Compound 17p1 Carbonic anhydrase 4 Homo sapiens 4.3 ChEMBL 10.1021/jm010163d 10.7270/Q2P84FN0 11831900 Kim, CY; Whittington, DA; Chang, JS; Liao, J; May, JA; Christianson, DW University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11390&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search INQ 1I91 4369172 46511932 DB03262 ZINC12503368 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51156783 COc1cccc(c1)N1C(CN2CCOCC2)=Cc2cc(sc2S1(=O)=O)S(N)(=O)=O InChI=1S/C18H21N3O6S3/c1-26-16-4-2-3-14(11-16)21-15(12-20-5-7-27-8-6-20)9-13-10-17(29(19,22)23)28-18(13)30(21,24)25/h2-4,9-11H,5-8,12H2,1H3,(H2,19,22,23) XSUAVPPTKHUTDX-UHFFFAOYSA-N 11391 2-(3-Methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno-[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide::2-(3-methoxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-dioxo-2H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::AL-6629::Compound 17k1 Carbonic anhydrase 4 Homo sapiens 7.4 ChEMBL 10.1021/jm010163d 10.7270/Q2P84FN0 11831900 Kim, CY; Whittington, DA; Chang, JS; Liao, J; May, JA; Christianson, DW University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11391&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search INL 1I8Z 4369171 46511933 DB03598 ZINC12503776 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51156786 COCCCN1C[C@H](N)c2cc(sc2S1(=O)=O)S(N)(=O)=O InChI=1S/C10H17N3O5S3/c1-18-4-2-3-13-6-8(11)7-5-9(20(12,14)15)19-10(7)21(13,16)17/h5,8H,2-4,6,11H2,1H3,(H2,12,14,15)/t8-/m0/s1 MVBJPOIMDXIBKC-QMMMGPOBSA-N 11392 (4R)-4-amino-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::AL-8520 Carbonic anhydrase 4 Homo sapiens 128 ChEMBL 10.1021/jm010163d 10.7270/Q2P84FN0 11831900 Kim, CY; Whittington, DA; Chang, JS; Liao, J; May, JA; Christianson, DW University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11392&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10021113 46511934 ZINC13558687 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51156787 CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1 HCRKCZRJWPKOAR-JTQLQIEISA-N 10885 (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::(R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-E)-1,2-thiazine-6-sulfonamide 1,1-dioxide::AL-4862::Azopt::Brinzolamide (BRZ)::brinzolamide Carbonic anhydrase 4 Homo sapiens 45 ChEMBL 10.1021/jm010163d 10.7270/Q2P84FN0 11831900 Kim, CY; Whittington, DA; Chang, JS; Liao, J; May, JA; Christianson, DW University of Pennsylvania http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10885&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BZ1 3ZNC,4M2V,4M2R,6BBS 68844 46511455 3176 DB01194 6797 C07760 ZINC03953037 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51141729 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acsmedchemlett.8b00334 10.7270/Q2959M8K 30344913 Angeli, A; Ferraroni, M; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51141742 NC(=N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1 InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14) XUFQPHANEAPEMJ-UHFFFAOYSA-N 50103514 CHEBI:4975::Famotidine::Fluxid::MK-208::Pepcid::Pepcid Ac::Pepcid Rpd Carbonic anhydrase 4 Homo sapiens 939 ChEMBL 10.1021/acsmedchemlett.8b00334 10.7270/Q2959M8K 30344913 Angeli, A; Ferraroni, M; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103514&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5702160 318491286 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145019 NS(=O)(=O)c1ccc(cc1)-c1ncc([se]1)C(O)=O InChI=1S/C10H8N2O4SSe/c11-17(15,16)7-3-1-6(2-4-7)9-12-5-8(18-9)10(13)14/h1-5H,(H,13,14)(H2,11,15,16) GEDYJPYOBLZQSS-UHFFFAOYSA-N 50469132 CHEMBL4278797 Carbonic anhydrase 4 Homo sapiens 392 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469132&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145979600 433936397 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145020 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145047 NC(=[Se])c1ccc(cc1)S(N)(=O)=O InChI=1S/C7H8N2O2SSe/c8-7(13)5-1-3-6(4-2-5)12(9,10)11/h1-4H,(H2,8,13)(H2,9,10,11) CZIIHSLWIYNAMW-UHFFFAOYSA-N 50469144 CHEMBL4293266 Carbonic anhydrase 4 Homo sapiens 941 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469144&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145988572 433936409 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145048 NS(=O)(=O)c1ccc(cc1)-c1ncc([se]1)-c1ccccc1 InChI=1S/C15H12N2O2SSe/c16-20(18,19)13-8-6-12(7-9-13)15-17-10-14(21-15)11-4-2-1-3-5-11/h1-10H,(H2,16,18,19) FMNYHPPTHRSLST-UHFFFAOYSA-N 50469143 CHEMBL4293677 Carbonic anhydrase 4 Homo sapiens 652 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469143&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145987697 433936408 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145049 NS(=O)(=O)c1ccc(cc1)-c1ncc([se]1)-c1ccc(Cl)cc1 InChI=1S/C15H11ClN2O2SSe/c16-12-5-1-10(2-6-12)14-9-18-15(22-14)11-3-7-13(8-4-11)21(17,19)20/h1-9H,(H2,17,19,20) JYGGIMIJDKSSNC-UHFFFAOYSA-N 50469142 CHEMBL4286460 Carbonic anhydrase 4 Homo sapiens 873 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469142&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145993323 433936407 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145050 NS(=O)(=O)c1ccc(cc1)-c1ncc([se]1)-c1ccc(cc1)[N+]([O-])=O InChI=1S/C15H11N3O4SSe/c16-23(21,22)13-7-3-11(4-8-13)15-17-9-14(24-15)10-1-5-12(6-2-10)18(19)20/h1-9H,(H2,16,21,22) QKNVOKBWWPYBCJ-UHFFFAOYSA-N 50469146 CHEMBL4277055 Carbonic anhydrase 4 Homo sapiens 9386 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469146&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145985651 433936411 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145051 Cc1cnc([se]1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C10H10N2O2SSe/c1-7-6-12-10(16-7)8-2-4-9(5-3-8)15(11,13)14/h2-6H,1H3,(H2,11,13,14) XRDKKZGKJMUPRS-UHFFFAOYSA-N 50469140 CHEMBL4286710 Carbonic anhydrase 4 Homo sapiens 385 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469140&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145992666 433936405 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145052 NS(=O)(=O)c1ccc(cc1)-c1ncc(CSc2ccccc2)[se]1 InChI=1S/C16H14N2O2S2Se/c17-22(19,20)14-8-6-12(7-9-14)16-18-10-15(23-16)11-21-13-4-2-1-3-5-13/h1-10H,11H2,(H2,17,19,20) AEADENKIWYZXNX-UHFFFAOYSA-N 50469145 CHEMBL4293952 Carbonic anhydrase 4 Homo sapiens 6860 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469145&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145993866 433936410 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145053 NS(=O)(=O)c1ccc(cc1)-c1ncc(C[Te]c2ccccc2)[se]1 InChI=1S/C16H14N2O2SSeTe/c17-21(19,20)13-8-6-12(7-9-13)16-18-10-14(22-16)11-23-15-4-2-1-3-5-15/h1-10H,11H2,(H2,17,19,20) XIBJCSLHJGQWSV-UHFFFAOYSA-N 50469134 CHEMBL4293524 Carbonic anhydrase 4 Homo sapiens 5155 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469134&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145988368 433936399 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145054 Cc1ccc([Se]Cc2cnc([se]2)-c2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C17H16N2O2SSe2/c1-12-2-8-15(9-3-12)23-11-16-10-19-17(24-16)13-4-6-14(7-5-13)22(18,20)21/h2-10H,11H2,1H3,(H2,18,20,21) CRHBMCXVILSOLN-UHFFFAOYSA-N 50469137 CHEMBL4281852 Carbonic anhydrase 4 Homo sapiens 204 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469137&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145979949 433936402 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145055 COc1ccc([Se]Cc2cnc([se]2)-c2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C17H16N2O3SSe2/c1-22-13-4-8-15(9-5-13)24-11-16-10-19-17(25-16)12-2-6-14(7-3-12)23(18,20)21/h2-10H,11H2,1H3,(H2,18,20,21) SRFGQMGPNUZNDU-UHFFFAOYSA-N 50469139 CHEMBL4292479 Carbonic anhydrase 4 Homo sapiens 121 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469139&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145987408 433936404 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145056 Cl.NC(=N)SCc1cnc([se]1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C11H12N4O2S2Se/c12-11(13)18-6-9-5-15-10(20-9)7-1-3-8(4-2-7)19(14,16)17/h1-5H,6H2,(H3,12,13)(H2,14,16,17) USLQTADLNDRKAV-UHFFFAOYSA-N 50469138 CHEMBL4279797 Carbonic anhydrase 4 Homo sapiens 217 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469138&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145980765 433936403 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145081 NS(=O)(=O)c1ccc(cc1)-c1ncc([se]1)-c1ccc(Br)cc1 InChI=1S/C15H11BrN2O2SSe/c16-12-5-1-10(2-6-12)14-9-18-15(22-14)11-3-7-13(8-4-11)21(17,19)20/h1-9H,(H2,17,19,20) RIVXATBATHBBHV-UHFFFAOYSA-N 50469130 CHEMBL4278541 Carbonic anhydrase 4 Homo sapiens 3098 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469130&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145979831 433936395 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145086 COc1cccc(c1)-c1cnc([se]1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H14N2O3SSe/c1-21-13-4-2-3-12(9-13)15-10-18-16(23-15)11-5-7-14(8-6-11)22(17,19)20/h2-10H,1H3,(H2,17,19,20) SICIBEVTTATEAR-UHFFFAOYSA-N 50469141 CHEMBL4285006 Carbonic anhydrase 4 Homo sapiens 360 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469141&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145993265 433936406 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145087 NS(=O)(=O)c1ccc(cc1)-c1ncc(C[Se]c2ccccc2)[se]1 InChI=1S/C16H14N2O2SSe2/c17-21(19,20)13-8-6-12(7-9-13)16-18-10-15(23-16)11-22-14-4-2-1-3-5-14/h1-10H,11H2,(H2,17,19,20) MBPSISFLTWFAQH-UHFFFAOYSA-N 50469129 CHEMBL4282275 Carbonic anhydrase 4 Homo sapiens 751 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469129&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145980204 433936394 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145103 Cc1ccc([Te]Cc2cnc([se]2)-c2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C17H16N2O2SSeTe/c1-12-2-8-16(9-3-12)24-11-15-10-19-17(23-15)13-4-6-14(7-5-13)22(18,20)21/h2-10H,11H2,1H3,(H2,18,20,21) DFQJEJIHGPHDSY-UHFFFAOYSA-N 50469131 CHEMBL4285683 Carbonic anhydrase 4 Homo sapiens 2695 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469131&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145989992 433936396 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145114 NS(=O)(=O)c1ccc(cc1)-c1ncc([se]1)-c1ccc(F)cc1 InChI=1S/C15H11FN2O2SSe/c16-12-5-1-10(2-6-12)14-9-18-15(22-14)11-3-7-13(8-4-11)21(17,19)20/h1-9H,(H2,17,19,20) PPGFGLXTJXGAHB-UHFFFAOYSA-N 50469135 CHEMBL4283086 Carbonic anhydrase 4 Homo sapiens 6353 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469135&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145982039 433936400 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145115 NS(=O)(=O)c1ccc(cc1)-c1ncc(CCl)[se]1 InChI=1S/C10H9ClN2O2SSe/c11-5-9-6-13-10(17-9)7-1-3-8(4-2-7)16(12,14)15/h1-4,6H,5H2,(H2,12,14,15) UUSUUFIKTNRGKD-UHFFFAOYSA-N 50469133 CHEMBL4283364 Carbonic anhydrase 4 Homo sapiens 326 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469133&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search FMH 6H3Q 138455154 433936398 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51145116 COc1ccc([Te]Cc2cnc([se]2)-c2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C17H16N2O3SSeTe/c1-22-13-4-8-16(9-5-13)25-11-15-10-19-17(24-15)12-2-6-14(7-3-12)23(18,20)21/h2-10H,11H2,1H3,(H2,18,20,21) XZYKSCRUSASMEE-UHFFFAOYSA-N 50469136 CHEMBL4290136 Carbonic anhydrase 4 Homo sapiens 854 ChEMBL 10.1016/j.ejmech.2018.08.096 10.7270/Q2RR21ZR 30193219 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Department of University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50469136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50469136&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145987996 433936401 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51201056 COC(=O)CNc1nc(F)nc(NCCc2ccc(cc2)S(N)(=O)=O)n1 InChI=1S/C14H17FN6O4S/c1-25-11(22)8-18-14-20-12(15)19-13(21-14)17-7-6-9-2-4-10(5-3-9)26(16,23)24/h2-5H,6-8H2,1H3,(H2,16,23,24)(H2,17,18,19,20,21) VCATWVMENXDNSM-UHFFFAOYSA-N 50494035 CHEMBL2443317 Carbonic anhydrase 4 Homo sapiens 2744 ChEMBL 10.1016/j.bmc.2013.09.031 10.7270/Q2NG4TKD 24103430 Ceruso, M; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50494035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50494035&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 72696594 433961300 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51201057 NS(=O)(=O)c1ccc(Nc2nc(F)nc(NCCO)n2)cc1 InChI=1S/C11H13FN6O3S/c12-9-16-10(14-5-6-19)18-11(17-9)15-7-1-3-8(4-2-7)22(13,20)21/h1-4,19H,5-6H2,(H2,13,20,21)(H2,14,15,16,17,18) MZYBXAGQQQVJNS-UHFFFAOYSA-N 50494040 CHEMBL2443315 Carbonic anhydrase 4 Homo sapiens 2552 ChEMBL 10.1016/j.bmc.2013.09.031 10.7270/Q2NG4TKD 24103430 Ceruso, M; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50494040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50494040&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 72696592 433961305 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51201058 NS(=O)(=O)c1ccc(Nc2nc(F)nc(F)n2)cc1 InChI=1S/C9H7F2N5O2S/c10-7-14-8(11)16-9(15-7)13-5-1-3-6(4-2-5)19(12,17)18/h1-4H,(H2,12,17,18)(H,13,14,15,16) XWJFOYSMHGGZOH-UHFFFAOYSA-N 50494037 CHEMBL2443313 Carbonic anhydrase 4 Homo sapiens 717 ChEMBL 10.1016/j.bmc.2013.09.031 10.7270/Q2NG4TKD 24103430 Ceruso, M; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50494037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50494037&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 72696463 433961302 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51201077 NS(=O)(=O)c1ccc(CCNc2nc(F)nc(NCC(O)=O)n2)cc1 InChI=1S/C13H15FN6O4S/c14-11-18-12(20-13(19-11)17-7-10(21)22)16-6-5-8-1-3-9(4-2-8)25(15,23)24/h1-4H,5-7H2,(H,21,22)(H2,15,23,24)(H2,16,17,18,19,20) AMBHDDNANBNWFM-UHFFFAOYSA-N 50494039 CHEMBL2443318 Carbonic anhydrase 4 Homo sapiens 3660 ChEMBL 10.1016/j.bmc.2013.09.031 10.7270/Q2NG4TKD 24103430 Ceruso, M; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50494039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50494039&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 72696595 433961304 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51201082 CNc1nc(F)nc(Nc2ccc(cc2)S(N)(=O)=O)n1 InChI=1S/C10H11FN6O2S/c1-13-9-15-8(11)16-10(17-9)14-6-2-4-7(5-3-6)20(12,18)19/h2-5H,1H3,(H2,12,18,19)(H2,13,14,15,16,17) DYWRDVPIFZTPHB-UHFFFAOYSA-N 50494036 CHEMBL2443316 Carbonic anhydrase 4 Homo sapiens 603 ChEMBL 10.1016/j.bmc.2013.09.031 10.7270/Q2NG4TKD 24103430 Ceruso, M; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50494036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50494036&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 72696593 433961301 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51201094 NS(=O)(=O)c1ccc(CCNc2nc(F)nc(F)n2)cc1 InChI=1S/C11H11F2N5O2S/c12-9-16-10(13)18-11(17-9)15-6-5-7-1-3-8(4-2-7)21(14,19)20/h1-4H,5-6H2,(H2,14,19,20)(H,15,16,17,18) OUNVQDGTNYDRFN-UHFFFAOYSA-N 50494038 CHEMBL2443314 Carbonic anhydrase 4 Homo sapiens 1360 ChEMBL 10.1016/j.bmc.2013.09.031 10.7270/Q2NG4TKD 24103430 Ceruso, M; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50494038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50494038&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 72696591 433961303 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51201099 CNc1nc(NC)nc(Nc2ccc(cc2)S(N)(=O)=O)n1 InChI=1S/C11H15N7O2S/c1-13-9-16-10(14-2)18-11(17-9)15-7-3-5-8(6-4-7)21(12,19)20/h3-6H,1-2H3,(H2,12,19,20)(H3,13,14,15,16,17,18) MMNZRPLKXCXVSZ-UHFFFAOYSA-N 50153972 4-(4,6-Bis-methylamino-[1,3,5]triazin-2-ylamino)-benzenesulfonamide::CHEMBL186716 Carbonic anhydrase 4 Homo sapiens 704 ChEMBL 10.1016/j.bmc.2013.09.031 10.7270/Q2NG4TKD 24103430 Ceruso, M; Vullo, D; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153972&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44395149 104041723 CHEMBL186716 ZINC28389402 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51203863 Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc1ccc(nc1)S(N)(=O)=O InChI=1S/C13H14N4O5S2/c1-9-2-5-11(6-3-9)24(21,22)17-13(18)16-10-4-7-12(15-8-10)23(14,19)20/h2-8H,1H3,(H2,14,19,20)(H2,16,17,18) PBRJWJGMKVRIRK-UHFFFAOYSA-N 50030557 CHEMBL3099282 Carbonic anhydrase 4 Homo sapiens 627 ChEMBL 10.1016/j.bmc.2013.11.016 10.7270/Q2K64N27 24300919 Bozdag, M; Ferraroni, M; Nuti, E; Vullo, D; Rossello, A; Carta, F; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030557&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search MB7 4KV0 73054728 313065865 CHEMBL3099282 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51203864 Nc1ccc(nc1)S(N)(=O)=O InChI=1S/C5H7N3O2S/c6-4-1-2-5(8-3-4)11(7,9)10/h1-3H,6H2,(H2,7,9,10) SFCUESWCLXDTCC-UHFFFAOYSA-N 50494958 CHEMBL3099281 Carbonic anhydrase 4 Homo sapiens 9540 ChEMBL 10.1016/j.bmc.2013.11.016 10.7270/Q2K64N27 24300919 Bozdag, M; Ferraroni, M; Nuti, E; Vullo, D; Rossello, A; Carta, F; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50494958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50494958&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 22313850 433962223 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51203865 Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C14H15N3O5S2/c1-10-2-6-13(7-3-10)24(21,22)17-14(18)16-11-4-8-12(9-5-11)23(15,19)20/h2-9H,1H3,(H2,15,19,20)(H2,16,17,18) HDCXQTPVTAIPNZ-UHFFFAOYSA-N 50349858 CHEMBL78755 Carbonic anhydrase 4 Homo sapiens 146 ChEMBL 10.1016/j.bmc.2013.11.016 10.7270/Q2K64N27 24300919 Bozdag, M; Ferraroni, M; Nuti, E; Vullo, D; Rossello, A; Carta, F; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349858&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search NR2 1ZFK 6852128 136356544 CHEMBL78755 DB08301 ZINC26474822 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51203866 Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) FDDDEECHVMSUSB-UHFFFAOYSA-N 10857 4-aminobenzene-1-sulfonamide::CHEMBL21::Sulfanilamide::aromatic sulfonamide compound 5::aromatic/heteroaromatic sulfonamide 2::halogenosulfanilamide deriv. 5a Carbonic anhydrase 4 Homo sapiens 9760 ChEMBL 10.1016/j.bmc.2013.11.016 10.7270/Q2K64N27 24300919 Bozdag, M; Ferraroni, M; Nuti, E; Vullo, D; Rossello, A; Carta, F; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10857&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search SAN 8BCB,1AJ0,4F93,4F92,4COQ,6RL9 5333 46511429 45373 CHEMBL21 DB00259 C07458 ZINC00002101 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51203906 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2013.11.016 10.7270/Q2K64N27 24300919 Bozdag, M; Ferraroni, M; Nuti, E; Vullo, D; Rossello, A; Carta, F; Scozzafava, A; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216752 NS(=O)(=O)c1ccc(CN2C(=O)c3ccc(cc3C2=O)C(=O)Nc2ccccc2C(O)=O)cc1 InChI=1S/C23H17N3O7S/c24-34(32,33)15-8-5-13(6-9-15)12-26-21(28)16-10-7-14(11-18(16)22(26)29)20(27)25-19-4-2-1-3-17(19)23(30)31/h1-11H,12H2,(H,25,27)(H,30,31)(H2,24,32,33) KJLIUNMQXVHGKJ-UHFFFAOYSA-N 50500019 CHEMBL3742377 Carbonic anhydrase 4 Homo sapiens 73 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500019&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127039154 433911920 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216762 NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)Nc1ccccc1C(O)=O InChI=1S/C22H15N3O7S/c23-33(31,32)14-8-6-13(7-9-14)25-20(27)15-10-5-12(11-17(15)21(25)28)19(26)24-18-4-2-1-3-16(18)22(29)30/h1-11H,(H,24,26)(H,29,30)(H2,23,31,32) DRMHRGCMQGYMGV-UHFFFAOYSA-N 50500026 CHEMBL3741546 Carbonic anhydrase 4 Homo sapiens 184 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500026&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127039153 433911927 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216766 OC(=O)c1cc(I)ccc1NC(=O)c1ccc2C(=O)OC(=O)c2c1 InChI=1S/C16H8INO6/c17-8-2-4-12(11(6-8)14(20)21)18-13(19)7-1-3-9-10(5-7)16(23)24-15(9)22/h1-6H,(H,18,19)(H,20,21) DXQBWMIOVSYYKC-UHFFFAOYSA-N 50500028 CHEMBL3740937 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500028&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127037756 433911929 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216776 OC(=O)c1ccccc1NC(=O)c1ccc2C(=O)OC(=O)c2c1 InChI=1S/C16H9NO6/c18-13(17-12-4-2-1-3-10(12)14(19)20)8-5-6-9-11(7-8)16(22)23-15(9)21/h1-7H,(H,17,18)(H,19,20) PGBRLTJLKQAASK-UHFFFAOYSA-N 50500021 CHEMBL3739554 Carbonic anhydrase 4 Homo sapiens 494 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500021&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 46868356 433911922 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216777 OC(=O)c1cc(Cl)ccc1NC(=O)c1ccc2C(=O)OC(=O)c2c1 InChI=1S/C16H8ClNO6/c17-8-2-4-12(11(6-8)14(20)21)18-13(19)7-1-3-9-10(5-7)16(23)24-15(9)22/h1-6H,(H,18,19)(H,20,21) PVLGBXMEDNNLRH-UHFFFAOYSA-N 50500025 CHEMBL3740241 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500025&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127037755 433911926 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216778 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216779 NS(=O)(=O)c1ccc(CCN2C(=O)c3ccc(cc3C2=O)C(=O)Nc2ccccc2C(O)=O)cc1 InChI=1S/C24H19N3O7S/c25-35(33,34)16-8-5-14(6-9-16)11-12-27-22(29)17-10-7-15(13-19(17)23(27)30)21(28)26-20-4-2-1-3-18(20)24(31)32/h1-10,13H,11-12H2,(H,26,28)(H,31,32)(H2,25,33,34) AQAHXHQTCBKILC-UHFFFAOYSA-N 50500023 CHEMBL3741601 Carbonic anhydrase 4 Homo sapiens 496 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500023&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127039155 433911924 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216780 OC(=O)c1ccccc1NC(=O)c1ccc2C(=O)N(CCc3ccccc3)C(=O)c2c1 InChI=1S/C24H18N2O5/c27-21(25-20-9-5-4-8-18(20)24(30)31)16-10-11-17-19(14-16)23(29)26(22(17)28)13-12-15-6-2-1-3-7-15/h1-11,14H,12-13H2,(H,25,27)(H,30,31) YWBXPSSBGBQOQI-UHFFFAOYSA-N 50500031 CHEMBL3742007 Carbonic anhydrase 4 Homo sapiens 366 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500031&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127039479 433911932 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216793 OC(=O)c1ccccc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccccc1 InChI=1S/C22H14N2O5/c25-19(23-18-9-5-4-8-16(18)22(28)29)13-10-11-15-17(12-13)21(27)24(20(15)26)14-6-2-1-3-7-14/h1-12H,(H,23,25)(H,28,29) RGRFEPRNSJRTHK-UHFFFAOYSA-N 50500020 CHEMBL3740022 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500020&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 3950536 433911921 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216800 COc1cc(NC(=O)c2ccc3C(=O)OC(=O)c3c2)c(cc1OC)C(O)=O InChI=1S/C18H13NO8/c1-25-13-6-11(16(21)22)12(7-14(13)26-2)19-15(20)8-3-4-9-10(5-8)18(24)27-17(9)23/h3-7H,1-2H3,(H,19,20)(H,21,22) WDOPRGZLPROWOP-UHFFFAOYSA-N 50500024 CHEMBL3740966 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500024&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127040041 433911925 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216801 OC(=O)c1ccccc1NC(=O)c1ccc2C(=O)N(Cc3ccccc3)C(=O)c2c1 InChI=1S/C23H16N2O5/c26-20(24-19-9-5-4-8-17(19)23(29)30)15-10-11-16-18(12-15)22(28)25(21(16)27)13-14-6-2-1-3-7-14/h1-12H,13H2,(H,24,26)(H,29,30) GQEVVWHZGOCRCN-UHFFFAOYSA-N 50500027 CHEMBL3740074 Carbonic anhydrase 4 Homo sapiens 7109 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500027&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1316238 433911928 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216802 CCOC(=O)c1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)Nc1ccccc1C(O)=O InChI=1S/C25H18N2O7/c1-2-34-25(33)14-7-10-16(11-8-14)27-22(29)17-12-9-15(13-19(17)23(27)30)21(28)26-20-6-4-3-5-18(20)24(31)32/h3-13H,2H2,1H3,(H,26,28)(H,31,32) FTWATXICDVIBPN-UHFFFAOYSA-N 50500029 CHEMBL3741953 Carbonic anhydrase 4 Homo sapiens 281 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500029&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1230924 433911930 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216810 OC(=O)c1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)Nc1ccccc1C(O)=O InChI=1S/C23H14N2O7/c26-19(24-18-4-2-1-3-16(18)23(31)32)13-7-10-15-17(11-13)21(28)25(20(15)27)14-8-5-12(6-9-14)22(29)30/h1-11H,(H,24,26)(H,29,30)(H,31,32) HZBPRFOEZIPHPY-UHFFFAOYSA-N 50500022 CHEMBL3740170 Carbonic anhydrase 4 Homo sapiens 892 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500022&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127042329 433911923 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51216811 Cc1ccc(NC(=O)c2ccc3C(=O)OC(=O)c3c2)c(c1)C(O)=O InChI=1S/C17H11NO6/c1-8-2-5-13(12(6-8)15(20)21)18-14(19)9-3-4-10-11(7-9)17(23)24-16(10)22/h2-7H,1H3,(H,18,19)(H,20,21) KMXVWNSZSJZBRK-UHFFFAOYSA-N 50500030 CHEMBL3740404 Carbonic anhydrase 4 Homo sapiens 527 ChEMBL 10.1016/j.bmc.2015.11.034 10.7270/Q29K4F79 26678172 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT King Saud University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50500030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50500030&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 127037757 433911931 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261979 NS(=O)(=O)c1ccc(OCC(O)C[Te]c2ccccc2)cc1 InChI=1S/C15H17NO4STe/c16-21(18,19)14-8-6-13(7-9-14)20-10-12(17)11-22-15-4-2-1-3-5-15/h1-9,12,17H,10-11H2,(H2,16,18,19) XWJTVJYMCSBFDT-UHFFFAOYSA-N 50515558 CHEMBL4535036 Carbonic anhydrase 4 Homo sapiens 6.8 ChEMBL 10.1016/j.ejmech.2019.111586 10.7270/Q2Z03CJ5 31401537 Tanini, D; Ricci, L; Capperucci, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515558&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155547730 440724140 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261993 CCCC[Te]CC(O)COc1ccc(cc1)S(N)(=O)=O InChI=1S/C13H21NO4STe/c1-2-3-8-20-10-11(15)9-18-12-4-6-13(7-5-12)19(14,16)17/h4-7,11,15H,2-3,8-10H2,1H3,(H2,14,16,17) ZNSHNQFDKSDPPK-UHFFFAOYSA-N 50515561 CHEMBL4442220 Carbonic anhydrase 4 Homo sapiens 916 ChEMBL 10.1016/j.ejmech.2019.111586 10.7270/Q2Z03CJ5 31401537 Tanini, D; Ricci, L; Capperucci, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515561&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155515285 440724143 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261994 Cc1ccc([Te]CC(O)COc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C16H19NO4STe/c1-12-2-8-16(9-3-12)23-11-13(18)10-21-14-4-6-15(7-5-14)22(17,19)20/h2-9,13,18H,10-11H2,1H3,(H2,17,19,20) OENRMXPXSFNCJJ-UHFFFAOYSA-N 50515559 CHEMBL4435078 Carbonic anhydrase 4 Homo sapiens 1.7 ChEMBL 10.1016/j.ejmech.2019.111586 10.7270/Q2Z03CJ5 31401537 Tanini, D; Ricci, L; Capperucci, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515559&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155511036 440724141 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261995 Cc1ccccc1[Te]CC(O)COc1ccc(cc1)S(N)(=O)=O InChI=1S/C16H19NO4STe/c1-12-4-2-3-5-16(12)23-11-13(18)10-21-14-6-8-15(9-7-14)22(17,19)20/h2-9,13,18H,10-11H2,1H3,(H2,17,19,20) LUBRMGCZSLCRGL-UHFFFAOYSA-N 50515563 CHEMBL4436769 Carbonic anhydrase 4 Homo sapiens 192 ChEMBL 10.1016/j.ejmech.2019.111586 10.7270/Q2Z03CJ5 31401537 Tanini, D; Ricci, L; Capperucci, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515563&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155512108 440724145 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261996 COc1ccc([Te]CC(O)COc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C16H19NO5STe/c1-21-13-4-8-16(9-5-13)24-11-12(18)10-22-14-2-6-15(7-3-14)23(17,19)20/h2-9,12,18H,10-11H2,1H3,(H2,17,19,20) RASGWFQDNMKKTJ-UHFFFAOYSA-N 50515557 CHEMBL4470177 Carbonic anhydrase 4 Homo sapiens 42 ChEMBL 10.1016/j.ejmech.2019.111586 10.7270/Q2Z03CJ5 31401537 Tanini, D; Ricci, L; Capperucci, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515557&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155534074 440724139 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261997 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2019.111586 10.7270/Q2Z03CJ5 31401537 Tanini, D; Ricci, L; Capperucci, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262011 CC[Te]CC(O)COc1ccc(cc1)S(N)(=O)=O InChI=1S/C11H17NO4STe/c1-2-18-8-9(13)7-16-10-3-5-11(6-4-10)17(12,14)15/h3-6,9,13H,2,7-8H2,1H3,(H2,12,14,15) MCWIKVGGAIUHQV-UHFFFAOYSA-N 50515560 CHEMBL4582229 Carbonic anhydrase 4 Homo sapiens 96 ChEMBL 10.1016/j.ejmech.2019.111586 10.7270/Q2Z03CJ5 31401537 Tanini, D; Ricci, L; Capperucci, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515560&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155561928 440724142 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262012 NS(=O)(=O)c1ccc(OCC(O)C[Te]c2ccc3ccccc3c2)cc1 InChI=1S/C19H19NO4STe/c20-25(22,23)18-8-6-17(7-9-18)24-12-16(21)13-26-19-10-5-14-3-1-2-4-15(14)11-19/h1-11,16,21H,12-13H2,(H2,20,22,23) MACPENRSDALHET-UHFFFAOYSA-N 50515562 CHEMBL4522383 Carbonic anhydrase 4 Homo sapiens 183 ChEMBL 10.1016/j.ejmech.2019.111586 10.7270/Q2Z03CJ5 31401537 Tanini, D; Ricci, L; Capperucci, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515562&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155542954 440724144 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262021 NS(=O)(=O)c1ccc(OCC(O)C[Te]CC(O)COc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C18H24N2O8S2Te/c19-29(23,24)17-5-1-15(2-6-17)27-9-13(21)11-31-12-14(22)10-28-16-3-7-18(8-4-16)30(20,25)26/h1-8,13-14,21-22H,9-12H2,(H2,19,23,24)(H2,20,25,26) JUPGTZUCOQORPY-UHFFFAOYSA-N 50515564 CHEMBL4535469 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.1016/j.ejmech.2019.111586 10.7270/Q2Z03CJ5 31401537 Tanini, D; Ricci, L; Capperucci, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515564&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search OJ4 6PGX 155547628 440724146 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51266086 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 75 ChEMBL 10.1016/j.bmc.2019.115086 10.7270/Q2WM1HSS 31515057 Kalinin, S; Valtari, A; Ruponen, M; Toropainen, E; Kovalenko, A; Nocentini, A; Gureev, M; Dar'in, D; Urtti, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51266087 NC1CCN(CC1)C(=O)c1ncc(o1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C15H18N4O4S/c16-11-5-7-19(8-6-11)15(20)14-18-9-13(23-14)10-1-3-12(4-2-10)24(17,21)22/h1-4,9,11H,5-8,16H2,(H2,17,21,22) AIYIMYJDUWTUFW-UHFFFAOYSA-N 50517102 CHEMBL4541944 Carbonic anhydrase 4 Homo sapiens 257 ChEMBL 10.1016/j.bmc.2019.115086 10.7270/Q2WM1HSS 31515057 Kalinin, S; Valtari, A; Ruponen, M; Toropainen, E; Kovalenko, A; Nocentini, A; Gureev, M; Dar'in, D; Urtti, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50517102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50517102&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155551316 440725684 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51266088 NS(=O)(=O)c1ccc(cc1)-c1cnc(o1)C(=O)NC1CCNCC1 InChI=1S/C15H18N4O4S/c16-24(21,22)12-3-1-10(2-4-12)13-9-18-15(23-13)14(20)19-11-5-7-17-8-6-11/h1-4,9,11,17H,5-8H2,(H,19,20)(H2,16,21,22) FBOQUPASYJUKKS-UHFFFAOYSA-N 50517104 CHEMBL4460569 Carbonic anhydrase 4 Homo sapiens 204 ChEMBL 10.1016/j.bmc.2019.115086 10.7270/Q2WM1HSS 31515057 Kalinin, S; Valtari, A; Ruponen, M; Toropainen, E; Kovalenko, A; Nocentini, A; Gureev, M; Dar'in, D; Urtti, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50517104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50517104&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155527975 440725686 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51266096 NS(=O)(=O)c1ccc(cc1)-c1cnc(o1)C(=O)N1CCNCC1 InChI=1S/C14H16N4O4S/c15-23(20,21)11-3-1-10(2-4-11)12-9-17-13(22-12)14(19)18-7-5-16-6-8-18/h1-4,9,16H,5-8H2,(H2,15,20,21) GPYPYCBSNFFZGO-UHFFFAOYSA-N 50517103 CHEMBL4452401 Carbonic anhydrase 4 Homo sapiens 420 ChEMBL 10.1016/j.bmc.2019.115086 10.7270/Q2WM1HSS 31515057 Kalinin, S; Valtari, A; Ruponen, M; Toropainen, E; Kovalenko, A; Nocentini, A; Gureev, M; Dar'in, D; Urtti, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50517103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50517103&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155523252 440725685 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51266097 NCCNC(=O)c1ncc(o1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C12H14N4O4S/c13-5-6-15-11(17)12-16-7-10(20-12)8-1-3-9(4-2-8)21(14,18)19/h1-4,7H,5-6,13H2,(H,15,17)(H2,14,18,19) ABERYJSQDXPIJE-UHFFFAOYSA-N 50517105 CHEMBL4582861 Carbonic anhydrase 4 Homo sapiens 39 ChEMBL 10.1016/j.bmc.2019.115086 10.7270/Q2WM1HSS 31515057 Kalinin, S; Valtari, A; Ruponen, M; Toropainen, E; Kovalenko, A; Nocentini, A; Gureev, M; Dar'in, D; Urtti, A; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50517105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50517105&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155566206 440725687 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261254 O=c1ccc2ccc(OCC#C)cc2o1 InChI=1S/C12H8O3/c1-2-7-14-10-5-3-9-4-6-12(13)15-11(9)8-10/h1,3-6,8H,7H2 IEHFVZKMAOKFTR-UHFFFAOYSA-N 50143207 CHEMBL308819 Carbonic anhydrase 4 Homo sapiens 76 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143207&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 13448444 85381511 CHEMBL308819 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261256 NS(=O)(=O)c1ccc(NCC#C)cc1 InChI=1S/C9H10N2O2S/c1-2-7-11-8-3-5-9(6-4-8)14(10,12)13/h1,3-6,11H,7H2,(H2,10,12,13) HPRYFTLQNXBKDM-UHFFFAOYSA-N 50515299 CHEMBL4454802 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515299&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10512636 440723881 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261264 NS(=O)(=O)c1ccc(cc1)C#C InChI=1S/C8H7NO2S/c1-2-7-3-5-8(6-4-7)12(9,10)11/h1,3-6H,(H2,9,10,11) OQPUCENNUFNCQO-UHFFFAOYSA-N 50236140 4-ethynyl benzene sulfonamide::4-ethynylbenzenesulfonamide::CHEMBL272881 Carbonic anhydrase 4 Homo sapiens 1357 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236140&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 44457221 104056248 CHEMBL272881 ZINC29134554 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261265 NS(=O)(=O)c1ccc([Se]CC#C)cc1 InChI=1S/C9H9NO2SSe/c1-2-7-14-9-5-3-8(4-6-9)13(10,11)12/h1,3-6H,7H2,(H2,10,11,12) LTZWHTYUYWWLJU-UHFFFAOYSA-N 50341395 CHEMBL4175369 Carbonic anhydrase 4 Homo sapiens 33 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341395&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145951720 131344331 ZINC71319145 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261266 NS(=O)(=O)c1ccc(cc1)N(CC#C)CC#C InChI=1S/C12H12N2O2S/c1-3-9-14(10-4-2)11-5-7-12(8-6-11)17(13,15)16/h1-2,5-8H,9-10H2,(H2,13,15,16) BBQOSXJFQHQFIV-UHFFFAOYSA-N 50066118 CHEMBL3402973 Carbonic anhydrase 4 Homo sapiens 1622 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066118&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 118729477 103960800 CHEMBL3402973 ZINC13780705 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261267 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261279 O=c1ccc2cc(OCC#C)ccc2o1 InChI=1S/C12H8O3/c1-2-7-14-10-4-5-11-9(8-10)3-6-12(13)15-11/h1,3-6,8H,7H2 BJPVWUGQYQUNTC-UHFFFAOYSA-N 50515300 CHEMBL3322093 Carbonic anhydrase 4 Homo sapiens 69 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515300&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 15783680 440723882 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261280 O=S1(=O)Oc2cc(OCC#C)ccc2C=C1 InChI=1S/C11H8O4S/c1-2-6-14-10-4-3-9-5-7-16(12,13)15-11(9)8-10/h1,3-5,7-8H,6H2 HNKJSUKNMWQSDT-UHFFFAOYSA-N 50515304 CHEMBL4519372 Carbonic anhydrase 4 Homo sapiens 62 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515304&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155541724 440723886 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261281 Cc1cc(=O)oc2cc(NCC#C)ccc12 InChI=1S/C13H11NO2/c1-3-6-14-10-4-5-11-9(2)7-13(15)16-12(11)8-10/h1,4-5,7-8,14H,6H2,2H3 UWUMXXUKMBZAIY-UHFFFAOYSA-N 50515305 CHEMBL4586124 Carbonic anhydrase 4 Homo sapiens 48 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515305&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129856021 440723887 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261290 NS(=O)(=O)c1ccc(SCC#C)cc1 InChI=1S/C9H9NO2S2/c1-2-7-13-8-3-5-9(6-4-8)14(10,11)12/h1,3-6H,7H2,(H2,10,11,12) WJCDGWZYMQENBH-UHFFFAOYSA-N 50515302 CHEMBL4462614 Carbonic anhydrase 4 Homo sapiens 839 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515302&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155529352 440723884 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261291 NS(=O)(=O)c1ccc(OCCCCN(CC#C)CC#C)cc1 InChI=1S/C16H20N2O3S/c1-3-11-18(12-4-2)13-5-6-14-21-15-7-9-16(10-8-15)22(17,19)20/h1-2,7-10H,5-6,11-14H2,(H2,17,19,20) GOFLUTLYXREFIG-UHFFFAOYSA-N 50515303 CHEMBL4435346 Carbonic anhydrase 4 Homo sapiens 1717 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515303&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155511133 440723885 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261296 O=S1(=O)Oc2ccc(OCC#C)cc2C=C1 InChI=1S/C11H8O4S/c1-2-6-14-10-3-4-11-9(8-10)5-7-16(12,13)15-11/h1,3-5,7-8H,6H2 GUSAFFVHXSQLGX-UHFFFAOYSA-N 50515298 CHEMBL4448721 Carbonic anhydrase 4 Homo sapiens 60 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515298&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155520507 440723880 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261297 S=c1ccc2ccc(OCC#C)cc2o1 InChI=1S/C12H8O2S/c1-2-7-13-10-5-3-9-4-6-12(15)14-11(9)8-10/h1,3-6,8H,7H2 QDQGOKLMXLFHFV-UHFFFAOYSA-N 50143208 CHEMBL3758522 Carbonic anhydrase 4 Homo sapiens 47 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143208&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10264933 85380617 CHEMBL3758522 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261299 NS(=O)(=O)c1ccc(CCN(CC#C)CC#C)cc1 InChI=1S/C14H16N2O2S/c1-3-10-16(11-4-2)12-9-13-5-7-14(8-6-13)19(15,17)18/h1-2,5-8H,9-12H2,(H2,15,17,18) REAJNGQFHWZSAP-UHFFFAOYSA-N 50515301 CHEMBL4566851 Carbonic anhydrase 4 Homo sapiens 371 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515301&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 86692720 440723883 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51261300 NS(=O)(=O)c1ccc(OCC#C)cc1 InChI=1S/C9H9NO3S/c1-2-7-13-8-3-5-9(6-4-8)14(10,11)12/h1,3-6H,7H2,(H2,10,11,12) BWZTYHANPJYDDW-UHFFFAOYSA-N 50066131 CHEMBL3402961 Carbonic anhydrase 4 Homo sapiens 1735 ChEMBL 10.1021/acs.jmedchem.9b00845 10.7270/Q2D79FRD 31287314 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066131&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 82911195 103960813 CHEMBL3402961 ZINC13780723 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231787 NS(=O)(=O)c1cc(C(O)=O)c(Br)cc1Br InChI=1S/C7H5Br2NO4S/c8-4-2-5(9)6(15(10,13)14)1-3(4)7(11)12/h1-2H,(H,11,12)(H2,10,13,14) NJWAUKHMSHZTLQ-UHFFFAOYSA-N 50449811 CHEMBL4165127 Carbonic anhydrase 4 Homo sapiens 1.6 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449811&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507856 433919374 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231788 NC(=O)c1cc(c(Cl)cc1SC1CCCCC1)S(N)(=O)=O InChI=1S/C13H17ClN2O3S2/c14-10-7-11(20-8-4-2-1-3-5-8)9(13(15)17)6-12(10)21(16,18)19/h6-8H,1-5H2,(H2,15,17)(H2,16,18,19) AUMZYYXDKOTCJB-UHFFFAOYSA-N 50504939 CHEMBL4586089 Carbonic anhydrase 4 Homo sapiens 0.230000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504939&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155566763 440713524 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231789 NS(=O)(=O)c1cc(C(=O)NCCCO)c(Cl)cc1Cl InChI=1S/C10H12Cl2N2O4S/c11-7-5-8(12)9(19(13,17)18)4-6(7)10(16)14-2-1-3-15/h4-5,15H,1-3H2,(H,14,16)(H2,13,17,18) OZBGWVAREHIEDY-UHFFFAOYSA-N 50449827 CHEMBL4173471 Carbonic anhydrase 4 Homo sapiens 0.030000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449827&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508709 433919389 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231790 CCCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C11H14Cl2N2O3S/c1-2-3-4-15-11(16)7-5-10(19(14,17)18)9(13)6-8(7)12/h5-6H,2-4H2,1H3,(H,15,16)(H2,14,17,18) KRIUYRKSVUBELV-UHFFFAOYSA-N 50449816 CHEMBL4160149 Carbonic anhydrase 4 Homo sapiens 0.350000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449816&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ENN 6G5U,6G6T 34852311 433919379 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231791 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C12H14Cl2N2O5S/c1-21-11(17)3-2-4-16-12(18)7-5-10(22(15,19)20)9(14)6-8(7)13/h5-6H,2-4H2,1H3,(H,16,18)(H2,15,19,20) HPOYDHZZGCZYRF-UHFFFAOYSA-N 50449818 CHEMBL4165896 Carbonic anhydrase 4 Homo sapiens 0.470000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449818&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508879 433919381 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231792 NS(=O)(=O)c1cc(C(=O)N2CCOCC2)c(Sc2ccccc2)cc1Cl InChI=1S/C17H17ClN2O4S2/c18-14-11-15(25-12-4-2-1-3-5-12)13(10-16(14)26(19,22)23)17(21)20-6-8-24-9-7-20/h1-5,10-11H,6-9H2,(H2,19,22,23) KCHKZYKQHJUTFV-UHFFFAOYSA-N 50504945 CHEMBL4579206 Carbonic anhydrase 4 Homo sapiens 7.9 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504945&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507944 440713530 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231793 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(SCCO)cc1Cl InChI=1S/C15H21ClN2O4S2/c16-12-9-13(23-7-6-19)11(8-14(12)24(17,21)22)15(20)18-10-4-2-1-3-5-10/h8-10,19H,1-7H2,(H,18,20)(H2,17,21,22) UYZHGPXBEKLXKD-UHFFFAOYSA-N 50504936 CHEMBL4464996 Carbonic anhydrase 4 Homo sapiens 0.570000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504936&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508234 440713521 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231794 NS(=O)(=O)c1cc(C(=O)NCCO)c(Sc2ccccc2)cc1Br InChI=1S/C15H15BrN2O4S2/c16-12-9-13(23-10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)24(17,21)22/h1-5,8-9,19H,6-7H2,(H,18,20)(H2,17,21,22) PRYBEVSATZDKFU-UHFFFAOYSA-N 50504954 CHEMBL4593681 Carbonic anhydrase 4 Homo sapiens 0.030000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504954&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508295 440713539 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231795 CCCCNC(=O)c1cc(c(Br)cc1Br)S(N)(=O)=O InChI=1S/C11H14Br2N2O3S/c1-2-3-4-15-11(16)7-5-10(19(14,17)18)9(13)6-8(7)12/h5-6H,2-4H2,1H3,(H,15,16)(H2,14,17,18) QKIXSEIIKHMOKR-UHFFFAOYSA-N 50449836 CHEMBL4166643 Carbonic anhydrase 4 Homo sapiens 0.170000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449836&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509349 433919398 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231796 CCCCNC(=O)c1cc(c(Br)cc1SCCO)S(N)(=O)=O InChI=1S/C13H19BrN2O4S2/c1-2-3-4-16-13(18)9-7-12(22(15,19)20)10(14)8-11(9)21-6-5-17/h7-8,17H,2-6H2,1H3,(H,16,18)(H2,15,19,20) YEPSGVPRNAGLAA-UHFFFAOYSA-N 50504942 CHEMBL4521683 Carbonic anhydrase 4 Homo sapiens 0.060000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504942&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508178 440713527 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230684 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 12 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230692 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 87 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231856 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C18H19ClN2O5S2/c1-26-17(22)8-5-9-21-18(23)13-10-16(28(20,24)25)14(19)11-15(13)27-12-6-3-2-4-7-12/h2-4,6-7,10-11H,5,8-9H2,1H3,(H,21,23)(H2,20,24,25) SYUNDQXGLSULAL-UHFFFAOYSA-N 50504941 CHEMBL4465972 Carbonic anhydrase 4 Homo sapiens 0.008100 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504941&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155531851 440713526 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231893 NS(=O)(=O)c1cc(C(=O)NCCO)c(cc1Cl)S(=O)(=O)C1CCCCC1 InChI=1S/C15H21ClN2O6S2/c16-12-9-13(25(21,22)10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)26(17,23)24/h8-10,19H,1-7H2,(H,18,20)(H2,17,23,24) XESFZDLAWXFOQS-UHFFFAOYSA-N 50504920 CHEMBL4459385 Carbonic anhydrase 4 Homo sapiens 0.510000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504920&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508714 440713505 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231894 COCCNC(=O)c1cc(c(Cl)cc1S(=O)(=O)C1CCCCC1)S(N)(=O)=O InChI=1S/C16H23ClN2O6S2/c1-25-8-7-19-16(20)12-9-15(27(18,23)24)13(17)10-14(12)26(21,22)11-5-3-2-4-6-11/h9-11H,2-8H2,1H3,(H,19,20)(H2,18,23,24) HBFALEBDZRZUTP-UHFFFAOYSA-N 50504924 CHEMBL4579465 Carbonic anhydrase 4 Homo sapiens 0.730000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504924&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508465 440713509 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231895 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(cc1Cl)S(=O)(=O)c1ccccc1 InChI=1S/C19H21ClN2O5S2/c20-16-12-17(28(24,25)14-9-5-2-6-10-14)15(11-18(16)29(21,26)27)19(23)22-13-7-3-1-4-8-13/h2,5-6,9-13H,1,3-4,7-8H2,(H,22,23)(H2,21,26,27) VCTHPGGSJKHJDI-UHFFFAOYSA-N 50504902 CHEMBL4466735 Carbonic anhydrase 4 Homo sapiens 1.3 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504902&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509291 440713487 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231896 NS(=O)(=O)c1cc(C(=O)NCc2ccccc2)c(cc1Cl)S(=O)(=O)C1CCCCC1 InChI=1S/C20H23ClN2O5S2/c21-17-12-18(29(25,26)15-9-5-2-6-10-15)16(11-19(17)30(22,27)28)20(24)23-13-14-7-3-1-4-8-14/h1,3-4,7-8,11-12,15H,2,5-6,9-10,13H2,(H,23,24)(H2,22,27,28) ICDSIUVYLWJHJY-UHFFFAOYSA-N 50504950 CHEMBL4573963 Carbonic anhydrase 4 Homo sapiens 3.2 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504950&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508608 440713535 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231897 CCCCNC(=O)c1cc(c(Br)cc1S(=O)(=O)C1CCCCC1)S(N)(=O)=O InChI=1S/C17H25BrN2O5S2/c1-2-3-9-20-17(21)13-10-16(27(19,24)25)14(18)11-15(13)26(22,23)12-7-5-4-6-8-12/h10-12H,2-9H2,1H3,(H,20,21)(H2,19,24,25) ADZJIEUIYRWVJN-UHFFFAOYSA-N 50504903 CHEMBL4454599 Carbonic anhydrase 4 Homo sapiens 1.6 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504903&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508968 440713488 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231898 NS(=O)(=O)c1cc(C(=O)NCCCC(O)=O)c(SCc2ccccc2)cc1Cl InChI=1S/C18H19ClN2O5S2/c19-14-10-15(27-11-12-5-2-1-3-6-12)13(9-16(14)28(20,25)26)18(24)21-8-4-7-17(22)23/h1-3,5-6,9-10H,4,7-8,11H2,(H,21,24)(H,22,23)(H2,20,25,26) VSGAQEPRDWDRPO-UHFFFAOYSA-N 50504919 CHEMBL4445515 Carbonic anhydrase 4 Homo sapiens 0.170000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504919&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155517801 440713504 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231904 COCCNC(=O)c1cc(c(Cl)cc1SC1CCCCC1)S(N)(=O)=O InChI=1S/C16H23ClN2O4S2/c1-23-8-7-19-16(20)12-9-15(25(18,21)22)13(17)10-14(12)24-11-5-3-2-4-6-11/h9-11H,2-8H2,1H3,(H,19,20)(H2,18,21,22) XGTJWUIMMWSYOY-UHFFFAOYSA-N 50504909 CHEMBL4450456 Carbonic anhydrase 4 Homo sapiens 0.030000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504909&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508781 440713494 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230782 NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl InChI=1S/C7H5Cl2NO4S/c8-4-2-5(9)6(15(10,13)14)1-3(4)7(11)12/h1-2H,(H,11,12)(H2,10,13,14) ZSHHRBYVHTVRFK-UHFFFAOYSA-N 13075 2,4-dichloro-5-sulfamoylbenzoic acid::2000-01951::Lasamide (Hsba)::LeadQuest Compound 9 Carbonic anhydrase 4 Homo sapiens 1.3 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13075&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 17655 46513492 ZINC01088182 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230783 NS(=O)(=O)c1cc(C(O)=O)c(SCCc2ccccc2)cc1Cl InChI=1S/C15H14ClNO4S2/c16-12-9-13(22-7-6-10-4-2-1-3-5-10)11(15(18)19)8-14(12)23(17,20)21/h1-5,8-9H,6-7H2,(H,18,19)(H2,17,20,21) XUXDCUQYQUMQNX-UHFFFAOYSA-N 50504938 CHEMBL4578934 Carbonic anhydrase 4 Homo sapiens 0.180000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504938&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155565307 440713523 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230784 NC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C7H6Cl2N2O3S/c8-4-2-5(9)6(15(11,13)14)1-3(4)7(10)12/h1-2H,(H2,10,12)(H2,11,13,14) IPRGYSAYIGOGMN-UHFFFAOYSA-N 50449822 CHEMBL4175740 Carbonic anhydrase 4 Homo sapiens 1.1 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449822&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12698190 433919385 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230785 NC(=O)c1cc(c(Cl)cc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C13H11ClN2O3S2/c14-10-7-11(20-8-4-2-1-3-5-8)9(13(15)17)6-12(10)21(16,18)19/h1-7H,(H2,15,17)(H2,16,18,19) MMYYEXLBLFTMSA-UHFFFAOYSA-N 50504915 CHEMBL4569008 Carbonic anhydrase 4 Homo sapiens 0.010000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504915&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155550495 440713500 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230786 NC(=O)c1cc(c(Cl)cc1SCc1ccccc1)S(N)(=O)=O InChI=1S/C14H13ClN2O3S2/c15-11-7-12(21-8-9-4-2-1-3-5-9)10(14(16)18)6-13(11)22(17,19)20/h1-7H,8H2,(H2,16,18)(H2,17,19,20) ANNKSEHPPUSPLF-UHFFFAOYSA-N 50504899 CHEMBL4456084 Carbonic anhydrase 4 Homo sapiens 0.110000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504899&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155524582 440713484 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230787 NS(=O)(=O)c1cc(C(=O)NCCO)c(SC2CCCCC2)cc1Cl InChI=1S/C15H21ClN2O4S2/c16-12-9-13(23-10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)24(17,21)22/h8-10,19H,1-7H2,(H,18,20)(H2,17,21,22) PSEDAEWMXCWYRT-UHFFFAOYSA-N 50504949 CHEMBL4450545 Carbonic anhydrase 4 Homo sapiens 0.030000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504949&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EA3 6R6Y,6R6F 126508406 440713534 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230788 NS(=O)(=O)c1cc(C(=O)NCCO)c(SCc2ccccc2)cc1Cl InChI=1S/C16H17ClN2O4S2/c17-13-9-14(24-10-11-4-2-1-3-5-11)12(16(21)19-6-7-20)8-15(13)25(18,22)23/h1-5,8-9,20H,6-7,10H2,(H,19,21)(H2,18,22,23) VVGWLEPPAHMEIE-UHFFFAOYSA-N 50504951 CHEMBL4565224 Carbonic anhydrase 4 Homo sapiens 0.060000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504951&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508707 440713536 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230789 NS(=O)(=O)c1cc(C(=O)NCCCO)c(Sc2ccccc2)cc1Cl InChI=1S/C16H17ClN2O4S2/c17-13-10-14(24-11-5-2-1-3-6-11)12(9-15(13)25(18,22)23)16(21)19-7-4-8-20/h1-3,5-6,9-10,20H,4,7-8H2,(H,19,21)(H2,18,22,23) BMTAXVGCZUSPJX-UHFFFAOYSA-N 50504916 CHEMBL4475496 Carbonic anhydrase 4 Homo sapiens 0.005000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504916&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search J8N 6QN5,6QUT 126508087 440713501 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230790 NS(=O)(=O)c1cc(C(=O)NCCCO)c(SC2CCCCC2)cc1Cl InChI=1S/C16H23ClN2O4S2/c17-13-10-14(24-11-5-2-1-3-6-11)12(9-15(13)25(18,22)23)16(21)19-7-4-8-20/h9-11,20H,1-8H2,(H,19,21)(H2,18,22,23) JUVRPCRQYSAHSW-UHFFFAOYSA-N 50504940 CHEMBL4475073 Carbonic anhydrase 4 Homo sapiens 0.110000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504940&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508603 440713525 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230791 CCCCNC(=O)c1cc(c(Cl)cc1SC1CCCCC1)S(N)(=O)=O InChI=1S/C17H25ClN2O3S2/c1-2-3-9-20-17(21)13-10-16(25(19,22)23)14(18)11-15(13)24-12-7-5-4-6-8-12/h10-12H,2-9H2,1H3,(H,20,21)(H2,19,22,23) WZHPNNQXMINMAU-UHFFFAOYSA-N 50504912 CHEMBL4451500 Carbonic anhydrase 4 Homo sapiens 0.010000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504912&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509009 440713497 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230792 COCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C10H12Cl2N2O4S/c1-18-3-2-14-10(15)6-4-9(19(13,16)17)8(12)5-7(6)11/h4-5H,2-3H2,1H3,(H,14,15)(H2,13,16,17) WVMBHAOCSXODMK-UHFFFAOYSA-N 50449829 CHEMBL4166964 Carbonic anhydrase 4 Homo sapiens 0.040000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449829&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 21189414 433919391 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230793 COCCNC(=O)c1cc(c(Cl)cc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C16H17ClN2O4S2/c1-23-8-7-19-16(20)12-9-15(25(18,21)22)13(17)10-14(12)24-11-5-3-2-4-6-11/h2-6,9-10H,7-8H2,1H3,(H,19,20)(H2,18,21,22) PYMMLRQNCFARGC-UHFFFAOYSA-N 50504922 CHEMBL4470832 Carbonic anhydrase 4 Homo sapiens 0.004000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504922&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508341 440713507 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230794 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1SCc1ccccc1)S(N)(=O)=O InChI=1S/C19H21ClN2O5S2/c1-27-18(23)8-5-9-22-19(24)14-10-17(29(21,25)26)15(20)11-16(14)28-12-13-6-3-2-4-7-13/h2-4,6-7,10-11H,5,8-9,12H2,1H3,(H,22,24)(H2,21,25,26) CPFIGMBLLZNRDF-UHFFFAOYSA-N 50504917 CHEMBL4572161 Carbonic anhydrase 4 Homo sapiens 0.020000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504917&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507693 440713502 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230795 NS(=O)(=O)c1cc(C(=O)N2CCOCC2)c(Cl)cc1Cl InChI=1S/C11H12Cl2N2O4S/c12-8-6-9(13)10(20(14,17)18)5-7(8)11(16)15-1-3-19-4-2-15/h5-6H,1-4H2,(H2,14,17,18) AVTRWXCLWDQMCF-UHFFFAOYSA-N 50449830 CHEMBL4173814 Carbonic anhydrase 4 Homo sapiens 1.4 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449830&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 60635890 433919392 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230796 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(Cl)cc1Cl InChI=1S/C13H16Cl2N2O3S/c14-10-7-11(15)12(21(16,19)20)6-9(10)13(18)17-8-4-2-1-3-5-8/h6-8H,1-5H2,(H,17,18)(H2,16,19,20) FYPYZSIHTPQQDJ-UHFFFAOYSA-N 50449834 CHEMBL4173501 Carbonic anhydrase 4 Homo sapiens 0.730000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449834&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 60635034 433919396 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230797 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(SC2CCCCC2)cc1Cl InChI=1S/C19H27ClN2O3S2/c20-16-12-17(26-14-9-5-2-6-10-14)15(11-18(16)27(21,24)25)19(23)22-13-7-3-1-4-8-13/h11-14H,1-10H2,(H,22,23)(H2,21,24,25) NLYBQJCQXDIDRT-UHFFFAOYSA-N 50504929 CHEMBL4551069 Carbonic anhydrase 4 Homo sapiens 0.270000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504929&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509146 440713514 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230798 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(SCc2ccccc2)cc1Cl InChI=1S/C20H23ClN2O3S2/c21-17-12-18(27-13-14-7-3-1-4-8-14)16(11-19(17)28(22,25)26)20(24)23-15-9-5-2-6-10-15/h1,3-4,7-8,11-12,15H,2,5-6,9-10,13H2,(H,23,24)(H2,22,25,26) ZUCBUUIASYMKCB-UHFFFAOYSA-N 50504935 CHEMBL4451503 Carbonic anhydrase 4 Homo sapiens 0.310000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504935&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508387 440713520 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230799 NS(=O)(=O)c1cc(C(=O)NCc2ccccc2)c(Sc2ccccc2)cc1Cl InChI=1S/C20H17ClN2O3S2/c21-17-12-18(27-15-9-5-2-6-10-15)16(11-19(17)28(22,25)26)20(24)23-13-14-7-3-1-4-8-14/h1-12H,13H2,(H,23,24)(H2,22,25,26) QHYFIYDKTOBCIG-UHFFFAOYSA-N 50504897 CHEMBL4562296 Carbonic anhydrase 4 Homo sapiens 0.020000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504897&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508758 440713482 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230800 NS(=O)(=O)c1cc(C(=O)NCCO)c(Br)cc1Br InChI=1S/C9H10Br2N2O4S/c10-6-4-7(11)8(18(12,16)17)3-5(6)9(15)13-1-2-14/h3-4,14H,1-2H2,(H,13,15)(H2,12,16,17) FASQQHIRLIBRPZ-UHFFFAOYSA-N 50449809 CHEMBL4168997 Carbonic anhydrase 4 Homo sapiens 0.300000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449809&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509027 433919372 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230801 NS(=O)(=O)c1cc(C(=O)NCCO)c(SCc2ccccc2)cc1Br InChI=1S/C16H17BrN2O4S2/c17-13-9-14(24-10-11-4-2-1-3-5-11)12(16(21)19-6-7-20)8-15(13)25(18,22)23/h1-5,8-9,20H,6-7,10H2,(H,19,21)(H2,18,22,23) YPSKJNDXYRNLMM-UHFFFAOYSA-N 50504960 CHEMBL4468310 Carbonic anhydrase 4 Homo sapiens 0.170000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504960&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507934 440713545 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230802 NS(=O)(=O)c1cc(C(=O)NCCO)c(SCCc2ccccc2)cc1Br InChI=1S/C17H19BrN2O4S2/c18-14-11-15(25-9-6-12-4-2-1-3-5-12)13(17(22)20-7-8-21)10-16(14)26(19,23)24/h1-5,10-11,21H,6-9H2,(H,20,22)(H2,19,23,24) XWTWKKFMRZDTAA-UHFFFAOYSA-N 50504930 CHEMBL4515586 Carbonic anhydrase 4 Homo sapiens 0.290000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504930&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507682 440713515 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230803 CCCCNC(=O)c1cc(c(Br)cc1SC1CCCCC1)S(N)(=O)=O InChI=1S/C17H25BrN2O3S2/c1-2-3-9-20-17(21)13-10-16(25(19,22)23)14(18)11-15(13)24-12-7-5-4-6-8-12/h10-12H,2-9H2,1H3,(H,20,21)(H2,19,22,23) YNYNIHPTYGGERR-UHFFFAOYSA-N 50504956 CHEMBL4446052 Carbonic anhydrase 4 Homo sapiens 0.110000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504956&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507854 440713541 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230804 CCCCNC(=O)c1cc(c(Br)cc1SCc1ccccc1)S(N)(=O)=O InChI=1S/C18H21BrN2O3S2/c1-2-3-9-21-18(22)14-10-17(26(20,23)24)15(19)11-16(14)25-12-13-7-5-4-6-8-13/h4-8,10-11H,2-3,9,12H2,1H3,(H,21,22)(H2,20,23,24) SVSTVNXTRFJTAJ-UHFFFAOYSA-N 50504913 CHEMBL4436290 Carbonic anhydrase 4 Homo sapiens 0.040000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504913&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508116 440713498 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230805 CCCCNC(=O)c1cc(c(Br)cc1SCCc1ccccc1)S(N)(=O)=O InChI=1S/C19H23BrN2O3S2/c1-2-3-10-22-19(23)15-12-18(27(21,24)25)16(20)13-17(15)26-11-9-14-7-5-4-6-8-14/h4-8,12-13H,2-3,9-11H2,1H3,(H,22,23)(H2,21,24,25) AUUAQVXOSSGYPF-UHFFFAOYSA-N 50504906 CHEMBL4468834 Carbonic anhydrase 4 Homo sapiens 0.060000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504906&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508271 440713491 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230806 NC(=O)c1cc(c(Cl)cc1S(=O)(=O)CCc1ccccc1)S(N)(=O)=O InChI=1S/C15H15ClN2O5S2/c16-12-9-13(11(15(17)19)8-14(12)25(18,22)23)24(20,21)7-6-10-4-2-1-3-5-10/h1-5,8-9H,6-7H2,(H2,17,19)(H2,18,22,23) SPZCGNHTIWEWEO-UHFFFAOYSA-N 50504926 CHEMBL4441818 Carbonic anhydrase 4 Homo sapiens 3.8 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504926&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155515548 440713511 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230807 NS(=O)(=O)c1cc(C(=O)NCCO)c(cc1Cl)S(=O)(=O)c1ccccc1 InChI=1S/C15H15ClN2O6S2/c16-12-9-13(25(21,22)10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)26(17,23)24/h1-5,8-9,19H,6-7H2,(H,18,20)(H2,17,23,24) KLUHDZWPAPUVIW-UHFFFAOYSA-N 50504953 CHEMBL4443095 Carbonic anhydrase 4 Homo sapiens 0.480000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504953&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search JTW 6R6J,6R71 126509224 440713538 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231935 NS(=O)(=O)c1cc(C(=O)NCCO)c(cc1Br)S(=O)(=O)C1CCCCC1 InChI=1S/C15H21BrN2O6S2/c16-12-9-13(25(21,22)10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)26(17,23)24/h8-10,19H,1-7H2,(H,18,20)(H2,17,23,24) KAMTXXAPTZNHJT-UHFFFAOYSA-N 50504925 CHEMBL4582964 Carbonic anhydrase 4 Homo sapiens 3.1 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504925&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508538 440713510 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231962 NS(=O)(=O)c1cc(C(=O)NCCCC(O)=O)c(Sc2ccccc2)cc1Cl InChI=1S/C17H17ClN2O5S2/c18-13-10-14(26-11-5-2-1-3-6-11)12(9-15(13)27(19,24)25)17(23)20-8-4-7-16(21)22/h1-3,5-6,9-10H,4,7-8H2,(H,20,23)(H,21,22)(H2,19,24,25) AYIOGQLVIDBCAX-UHFFFAOYSA-N 50504923 CHEMBL4584546 Carbonic anhydrase 4 Homo sapiens 4.8 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504923&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155565822 440713508 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232022 NS(=O)(=O)c1cc(C(=O)NCCO)c(Cl)cc1Cl InChI=1S/C9H10Cl2N2O4S/c10-6-4-7(11)8(18(12,16)17)3-5(6)9(15)13-1-2-14/h3-4,14H,1-2H2,(H,13,15)(H2,12,16,17) UISZEPPPNAJTCZ-UHFFFAOYSA-N 50449831 CHEMBL4172331 Carbonic anhydrase 4 Homo sapiens 1.7 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449831&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12698192 433919393 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232023 NS(=O)(=O)c1cc(C(=O)NCc2ccccc2)c(SC2CCCCC2)cc1Cl InChI=1S/C20H23ClN2O3S2/c21-17-12-18(27-15-9-5-2-6-10-15)16(11-19(17)28(22,25)26)20(24)23-13-14-7-3-1-4-8-14/h1,3-4,7-8,11-12,15H,2,5-6,9-10,13H2,(H,23,24)(H2,22,25,26) IHQUXGSVVLEKAV-UHFFFAOYSA-N 50504905 CHEMBL4442511 Carbonic anhydrase 4 Homo sapiens 0.230000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504905&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508912 440713490 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232029 CCCCNC(=O)c1cc(c(Cl)cc1S(=O)(=O)c1ccccc1)S(N)(=O)=O InChI=1S/C17H19ClN2O5S2/c1-2-3-9-20-17(21)13-10-16(27(19,24)25)14(18)11-15(13)26(22,23)12-7-5-4-6-8-12/h4-8,10-11H,2-3,9H2,1H3,(H,20,21)(H2,19,24,25) HNGWBCPNEWJHHT-UHFFFAOYSA-N 50504943 CHEMBL4583164 Carbonic anhydrase 4 Homo sapiens 0.250000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504943&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509299 440713528 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232049 NC(=O)c1cc(c(Cl)cc1SCc1ccccc1)S(N)(=O)=O InChI=1S/C14H13ClN2O3S2/c15-11-7-12(21-8-9-4-2-1-3-5-9)10(14(16)18)6-13(11)22(17,19)20/h1-7H,8H2,(H2,16,18)(H2,17,19,20) ANNKSEHPPUSPLF-UHFFFAOYSA-N 50504899 CHEMBL4456084 Carbonic anhydrase 4 Homo sapiens 64 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504899&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155524582 440713484 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232050 COCCNC(=O)c1cc(c(Cl)cc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C16H17ClN2O4S2/c1-23-8-7-19-16(20)12-9-15(25(18,21)22)13(17)10-14(12)24-11-5-3-2-4-6-11/h2-6,9-10H,7-8H2,1H3,(H,19,20)(H2,18,21,22) PYMMLRQNCFARGC-UHFFFAOYSA-N 50504922 CHEMBL4470832 Carbonic anhydrase 4 Homo sapiens 1.4 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504922&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508341 440713507 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232051 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(SCCO)cc1Cl InChI=1S/C15H21ClN2O4S2/c16-12-9-13(23-7-6-19)11(8-14(12)24(17,21)22)15(20)18-10-4-2-1-3-5-10/h8-10,19H,1-7H2,(H,18,20)(H2,17,21,22) UYZHGPXBEKLXKD-UHFFFAOYSA-N 50504936 CHEMBL4464996 Carbonic anhydrase 4 Homo sapiens 330 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504936&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508234 440713521 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232052 CC(=O)OCCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C12H14Cl2N2O5S/c1-7(17)21-4-2-3-16-12(18)8-5-11(22(15,19)20)10(14)6-9(8)13/h5-6H,2-4H2,1H3,(H,16,18)(H2,15,19,20) ZYZYGWWRCWBUMZ-UHFFFAOYSA-N 50449810 CHEMBL4162133 Carbonic anhydrase 4 Homo sapiens 50 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449810&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507183 433919373 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232097 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(cc1Cl)S(=O)(=O)C1CCCCC1 InChI=1S/C19H27ClN2O5S2/c20-16-12-17(28(24,25)14-9-5-2-6-10-14)15(11-18(16)29(21,26)27)19(23)22-13-7-3-1-4-8-13/h11-14H,1-10H2,(H,22,23)(H2,21,26,27) DBESSYOOZDFQBR-UHFFFAOYSA-N 50504958 CHEMBL4469236 Carbonic anhydrase 4 Homo sapiens 400 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504958&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508892 440713543 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232125 NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl InChI=1S/C7H5Cl2NO4S/c8-4-2-5(9)6(15(10,13)14)1-3(4)7(11)12/h1-2H,(H,11,12)(H2,10,13,14) ZSHHRBYVHTVRFK-UHFFFAOYSA-N 13075 2,4-dichloro-5-sulfamoylbenzoic acid::2000-01951::Lasamide (Hsba)::LeadQuest Compound 9 Carbonic anhydrase 4 Homo sapiens 1500 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13075&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 17655 46513492 ZINC01088182 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232126 NC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C7H6Cl2N2O3S/c8-4-2-5(9)6(15(11,13)14)1-3(4)7(10)12/h1-2H,(H2,10,12)(H2,11,13,14) IPRGYSAYIGOGMN-UHFFFAOYSA-N 50449822 CHEMBL4175740 Carbonic anhydrase 4 Homo sapiens 260 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449822&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12698190 433919385 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232127 NS(=O)(=O)c1cc(C(=O)NCCO)c(Sc2ccccc2)cc1Cl InChI=1S/C15H15ClN2O4S2/c16-12-9-13(23-10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)24(17,21)22/h1-5,8-9,19H,6-7H2,(H,18,20)(H2,17,21,22) XRTYWFQPSHFDQI-UHFFFAOYSA-N 50504944 CHEMBL4553519 Carbonic anhydrase 4 Homo sapiens 1.4 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504944&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507415 440713529 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232128 NS(=O)(=O)c1cc(C(=O)NCCCO)c(Sc2ccccc2)cc1Cl InChI=1S/C16H17ClN2O4S2/c17-13-10-14(24-11-5-2-1-3-6-11)12(9-15(13)25(18,22)23)16(21)19-7-4-8-20/h1-3,5-6,9-10,20H,4,7-8H2,(H,19,21)(H2,18,22,23) BMTAXVGCZUSPJX-UHFFFAOYSA-N 50504916 CHEMBL4475496 Carbonic anhydrase 4 Homo sapiens 1.7 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504916&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search J8N 6QN5,6QUT 126508087 440713501 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232129 COCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C10H12Cl2N2O4S/c1-18-3-2-14-10(15)6-4-9(19(13,16)17)8(12)5-7(6)11/h4-5H,2-3H2,1H3,(H,14,15)(H2,13,16,17) WVMBHAOCSXODMK-UHFFFAOYSA-N 50449829 CHEMBL4166964 Carbonic anhydrase 4 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449829&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 21189414 433919391 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232130 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C18H19ClN2O5S2/c1-26-17(22)8-5-9-21-18(23)13-10-16(28(20,24)25)14(19)11-15(13)27-12-6-3-2-4-7-12/h2-4,6-7,10-11H,5,8-9H2,1H3,(H,21,23)(H2,20,24,25) SYUNDQXGLSULAL-UHFFFAOYSA-N 50504941 CHEMBL4465972 Carbonic anhydrase 4 Homo sapiens 3.0 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504941&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155531851 440713526 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232131 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(Sc2ccccc2)cc1Cl InChI=1S/C19H21ClN2O3S2/c20-16-12-17(26-14-9-5-2-6-10-14)15(11-18(16)27(21,24)25)19(23)22-13-7-3-1-4-8-13/h2,5-6,9-13H,1,3-4,7-8H2,(H,22,23)(H2,21,24,25) IGLDOHLJJIKASI-UHFFFAOYSA-N 50504948 CHEMBL4573894 Carbonic anhydrase 4 Homo sapiens 56 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504948&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509024 440713533 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232132 NS(=O)(=O)c1cc(C(=O)NCc2ccccc2)c(Sc2ccccc2)cc1Cl InChI=1S/C20H17ClN2O3S2/c21-17-12-18(27-15-9-5-2-6-10-15)16(11-19(17)28(22,25)26)20(24)23-13-14-7-3-1-4-8-14/h1-12H,13H2,(H,23,24)(H2,22,25,26) QHYFIYDKTOBCIG-UHFFFAOYSA-N 50504897 CHEMBL4562296 Carbonic anhydrase 4 Homo sapiens 9.1 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504897&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508758 440713482 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232133 NS(=O)(=O)c1cc(C(=O)NCCO)c(SCc2ccccc2)cc1Br InChI=1S/C16H17BrN2O4S2/c17-13-9-14(24-10-11-4-2-1-3-5-11)12(16(21)19-6-7-20)8-15(13)25(18,22)23/h1-5,8-9,20H,6-7,10H2,(H,19,21)(H2,18,22,23) YPSKJNDXYRNLMM-UHFFFAOYSA-N 50504960 CHEMBL4468310 Carbonic anhydrase 4 Homo sapiens 100 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504960&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507934 440713545 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232134 CCCCNC(=O)c1cc(c(Br)cc1SC1CCCCC1)S(N)(=O)=O InChI=1S/C17H25BrN2O3S2/c1-2-3-9-20-17(21)13-10-16(25(19,22)23)14(18)11-15(13)24-12-7-5-4-6-8-12/h10-12H,2-9H2,1H3,(H,20,21)(H2,19,22,23) YNYNIHPTYGGERR-UHFFFAOYSA-N 50504956 CHEMBL4446052 Carbonic anhydrase 4 Homo sapiens 39 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504956&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507854 440713541 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232135 NC(=O)c1cc(c(Cl)cc1S(=O)(=O)CCc1ccccc1)S(N)(=O)=O InChI=1S/C15H15ClN2O5S2/c16-12-9-13(11(15(17)19)8-14(12)25(18,22)23)24(20,21)7-6-10-4-2-1-3-5-10/h1-5,8-9H,6-7H2,(H2,17,19)(H2,18,22,23) SPZCGNHTIWEWEO-UHFFFAOYSA-N 50504926 CHEMBL4441818 Carbonic anhydrase 4 Homo sapiens 290 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504926&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155515548 440713511 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232136 NS(=O)(=O)c1cc(C(=O)NCCCO)c(cc1Cl)S(=O)(=O)c1ccccc1 InChI=1S/C16H17ClN2O6S2/c17-13-10-14(26(22,23)11-5-2-1-3-6-11)12(9-15(13)27(18,24)25)16(21)19-7-4-8-20/h1-3,5-6,9-10,20H,4,7-8H2,(H,19,21)(H2,18,24,25) SMISDIGCWQEHKF-UHFFFAOYSA-N 50504957 CHEMBL4463844 Carbonic anhydrase 4 Homo sapiens 28 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504957&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507846 440713542 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231052 NS(=O)(=O)c1cc(C(=O)NCCO)c(cc1Cl)S(=O)(=O)Cc1ccccc1 InChI=1S/C16H17ClN2O6S2/c17-13-9-14(26(22,23)10-11-4-2-1-3-5-11)12(16(21)19-6-7-20)8-15(13)27(18,24)25/h1-5,8-9,20H,6-7,10H2,(H,19,21)(H2,18,24,25) KZUKWKADTYXYMJ-UHFFFAOYSA-N 50504901 CHEMBL4441901 Carbonic anhydrase 4 Homo sapiens 4.1 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504901&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507400 440713486 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231053 NS(=O)(=O)c1cc(C(=O)NCCCO)c(cc1Cl)S(=O)(=O)c1ccccc1 InChI=1S/C16H17ClN2O6S2/c17-13-10-14(26(22,23)11-5-2-1-3-6-11)12(9-15(13)27(18,24)25)16(21)19-7-4-8-20/h1-3,5-6,9-10,20H,4,7-8H2,(H,19,21)(H2,18,24,25) SMISDIGCWQEHKF-UHFFFAOYSA-N 50504957 CHEMBL4463844 Carbonic anhydrase 4 Homo sapiens 0.410000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504957&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507846 440713542 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231054 CCCCNC(=O)c1cc(c(Cl)cc1S(=O)(=O)C1CCCCC1)S(N)(=O)=O InChI=1S/C17H25ClN2O5S2/c1-2-3-9-20-17(21)13-10-16(27(19,24)25)14(18)11-15(13)26(22,23)12-7-5-4-6-8-12/h10-12H,2-9H2,1H3,(H,20,21)(H2,19,24,25) GUEMGVWYVLHLBC-UHFFFAOYSA-N 50504946 CHEMBL4450306 Carbonic anhydrase 4 Homo sapiens 0.420000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504946&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508314 440713531 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231055 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1S(=O)(=O)C1CCCCC1)S(N)(=O)=O InChI=1S/C18H25ClN2O7S2/c1-28-17(22)8-5-9-21-18(23)13-10-16(30(20,26)27)14(19)11-15(13)29(24,25)12-6-3-2-4-7-12/h10-12H,2-9H2,1H3,(H,21,23)(H2,20,26,27) OJCBLUGIJDOTFF-UHFFFAOYSA-N 50504921 CHEMBL4514121 Carbonic anhydrase 4 Homo sapiens 1.6 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504921&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509247 440713506 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231056 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1S(=O)(=O)Cc1ccccc1)S(N)(=O)=O InChI=1S/C19H21ClN2O7S2/c1-29-18(23)8-5-9-22-19(24)14-10-17(31(21,27)28)15(20)11-16(14)30(25,26)12-13-6-3-2-4-7-13/h2-4,6-7,10-11H,5,8-9,12H2,1H3,(H,22,24)(H2,21,27,28) NFUHGIUBDKRZQY-UHFFFAOYSA-N 50504931 CHEMBL4472400 Carbonic anhydrase 4 Homo sapiens 9.1 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504931&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507285 440713516 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231057 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(cc1Cl)S(=O)(=O)C1CCCCC1 InChI=1S/C19H27ClN2O5S2/c20-16-12-17(28(24,25)14-9-5-2-6-10-14)15(11-18(16)29(21,26)27)19(23)22-13-7-3-1-4-8-13/h11-14H,1-10H2,(H,22,23)(H2,21,26,27) DBESSYOOZDFQBR-UHFFFAOYSA-N 50504958 CHEMBL4469236 Carbonic anhydrase 4 Homo sapiens 5.8 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504958&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508892 440713543 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231058 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(cc1Cl)S(=O)(=O)Cc1ccccc1 InChI=1S/C20H23ClN2O5S2/c21-17-12-18(29(25,26)13-14-7-3-1-4-8-14)16(11-19(17)30(22,27)28)20(24)23-15-9-5-2-6-10-15/h1,3-4,7-8,11-12,15H,2,5-6,9-10,13H2,(H,23,24)(H2,22,27,28) YZJMQWTUVKKLNZ-UHFFFAOYSA-N 50504907 CHEMBL4529297 Carbonic anhydrase 4 Homo sapiens 34 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504907&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509170 440713492 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231059 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(cc1Cl)S(=O)(=O)CCO InChI=1S/C15H21ClN2O6S2/c16-12-9-13(25(21,22)7-6-19)11(8-14(12)26(17,23)24)15(20)18-10-4-2-1-3-5-10/h8-10,19H,1-7H2,(H,18,20)(H2,17,23,24) WEOFIRPZWSUJBC-UHFFFAOYSA-N 50504955 CHEMBL4549561 Carbonic anhydrase 4 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504955&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507192 440713540 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231060 NS(=O)(=O)c1cc(C(=O)NCCO)c(cc1Br)S(=O)(=O)Cc1ccccc1 InChI=1S/C16H17BrN2O6S2/c17-13-9-14(26(22,23)10-11-4-2-1-3-5-11)12(16(21)19-6-7-20)8-15(13)27(18,24)25/h1-5,8-9,20H,6-7,10H2,(H,19,21)(H2,18,24,25) PYLVVDNHUGVMGF-UHFFFAOYSA-N 50504918 CHEMBL4513913 Carbonic anhydrase 4 Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504918&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509348 440713503 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231061 CCCCNC(=O)c1cc(c(Br)cc1S(=O)(=O)c1ccccc1)S(N)(=O)=O InChI=1S/C17H19BrN2O5S2/c1-2-3-9-20-17(21)13-10-16(27(19,24)25)14(18)11-15(13)26(22,23)12-7-5-4-6-8-12/h4-8,10-11H,2-3,9H2,1H3,(H,20,21)(H2,19,24,25) FATAPRQFXGZRGG-UHFFFAOYSA-N 50504932 CHEMBL4576689 Carbonic anhydrase 4 Homo sapiens 0.160000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504932&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508716 440713517 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231062 NS(=O)(=O)c1cc(C(=O)NCCO)c(cc1Br)[S+]([O-])c1ccccc1 InChI=1S/C15H15BrN2O5S2/c16-12-9-13(24(21)10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)25(17,22)23/h1-5,8-9,19H,6-7H2,(H,18,20)(H2,17,22,23) WMAKPMGOFNHAFL-UHFFFAOYSA-N 50504908 CHEMBL4566236 Carbonic anhydrase 4 Homo sapiens 0.230000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504908&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508486 440713493 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231063 NS(=O)(=O)c1cc(C(=O)NCCCC(O)=O)c(Sc2ccccc2)cc1Cl InChI=1S/C17H17ClN2O5S2/c18-13-10-14(26-11-5-2-1-3-6-11)12(9-15(13)27(19,24)25)17(23)20-8-4-7-16(21)22/h1-3,5-6,9-10H,4,7-8H2,(H,20,23)(H,21,22)(H2,19,24,25) AYIOGQLVIDBCAX-UHFFFAOYSA-N 50504923 CHEMBL4584546 Carbonic anhydrase 4 Homo sapiens 0.010000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504923&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155565822 440713508 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231064 NS(=O)(=O)c1cc(C(=O)NCCCC(O)=O)c(SC2CCCCC2)cc1Cl InChI=1S/C17H23ClN2O5S2/c18-13-10-14(26-11-5-2-1-3-6-11)12(9-15(13)27(19,24)25)17(23)20-8-4-7-16(21)22/h9-11H,1-8H2,(H,20,23)(H,21,22)(H2,19,24,25) QBFWPSYDISFIKC-UHFFFAOYSA-N 50504904 CHEMBL4513684 Carbonic anhydrase 4 Homo sapiens 0.350000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504904&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508867 440713489 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231065 NS(=O)(=O)c1cc(C(=O)NCCCC(O)=O)c(cc1Cl)S(=O)(=O)Cc1ccccc1 InChI=1S/C18H19ClN2O7S2/c19-14-10-15(29(25,26)11-12-5-2-1-3-6-12)13(9-16(14)30(20,27)28)18(24)21-8-4-7-17(22)23/h1-3,5-6,9-10H,4,7-8,11H2,(H,21,24)(H,22,23)(H2,20,27,28) DZABBYYPQHZLHW-UHFFFAOYSA-N 50504910 CHEMBL4472135 Carbonic anhydrase 4 Homo sapiens 31 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504910&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507792 440713495 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232238 CC(=O)OCCCNC(=O)c1cc(c(Cl)cc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C18H19ClN2O5S2/c1-12(22)26-9-5-8-21-18(23)14-10-17(28(20,24)25)15(19)11-16(14)27-13-6-3-2-4-7-13/h2-4,6-7,10-11H,5,8-9H2,1H3,(H,21,23)(H2,20,24,25) XMVRIQFKEVJZEP-UHFFFAOYSA-N 50504934 CHEMBL4565560 Carbonic anhydrase 4 Homo sapiens 0.008000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504934&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126506968 440713519 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232251 NS(=O)(=O)c1cc(C(O)=O)c(SCCc2ccccc2)cc1Cl InChI=1S/C15H14ClNO4S2/c16-12-9-13(22-7-6-10-4-2-1-3-5-10)11(15(18)19)8-14(12)23(17,20)21/h1-5,8-9H,6-7H2,(H,18,19)(H2,17,20,21) XUXDCUQYQUMQNX-UHFFFAOYSA-N 50504938 CHEMBL4578934 Carbonic anhydrase 4 Homo sapiens 330 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504938&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155565307 440713523 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232252 CCCCNC(=O)c1cc(c(Br)cc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C17H19BrN2O3S2/c1-2-3-9-20-17(21)13-10-16(25(19,22)23)14(18)11-15(13)24-12-7-5-4-6-8-12/h4-8,10-11H,2-3,9H2,1H3,(H,20,21)(H2,19,22,23) JICSIQIOJHYBBO-UHFFFAOYSA-N 50504898 CHEMBL4437818 Carbonic anhydrase 4 Homo sapiens 3.5 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504898&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508267 440713483 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51232270 CCCCNC(=O)c1cc(c(Br)cc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C17H19BrN2O3S2/c1-2-3-9-20-17(21)13-10-16(25(19,22)23)14(18)11-15(13)24-12-7-5-4-6-8-12/h4-8,10-11H,2-3,9H2,1H3,(H,20,21)(H2,19,22,23) JICSIQIOJHYBBO-UHFFFAOYSA-N 50504898 CHEMBL4437818 Carbonic anhydrase 4 Homo sapiens 0.008000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504898&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508267 440713483 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231207 NS(=O)(=O)c1cc(C(O)=O)c(SC2CCCCC2)cc1Cl InChI=1S/C13H16ClNO4S2/c14-10-7-11(20-8-4-2-1-3-5-8)9(13(16)17)6-12(10)21(15,18)19/h6-8H,1-5H2,(H,16,17)(H2,15,18,19) RKWDVSIOPVQNEF-UHFFFAOYSA-N 50504959 CHEMBL4543024 Carbonic anhydrase 4 Homo sapiens 670 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504959&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155551734 440713544 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231282 NS(=O)(=O)c1cc(C(O)=O)c(Br)cc1Br InChI=1S/C7H5Br2NO4S/c8-4-2-5(9)6(15(10,13)14)1-3(4)7(11)12/h1-2H,(H,11,12)(H2,10,13,14) NJWAUKHMSHZTLQ-UHFFFAOYSA-N 50449811 CHEMBL4165127 Carbonic anhydrase 4 Homo sapiens 1200 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449811&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507856 433919374 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231283 NC(=O)c1cc(c(Cl)cc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C13H11ClN2O3S2/c14-10-7-11(20-8-4-2-1-3-5-8)9(13(15)17)6-12(10)21(16,18)19/h1-7H,(H2,15,17)(H2,16,18,19) MMYYEXLBLFTMSA-UHFFFAOYSA-N 50504915 CHEMBL4569008 Carbonic anhydrase 4 Homo sapiens 7.6 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504915&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155550495 440713500 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231284 NC(=O)c1cc(c(Cl)cc1SC1CCCCC1)S(N)(=O)=O InChI=1S/C13H17ClN2O3S2/c14-10-7-11(20-8-4-2-1-3-5-8)9(13(15)17)6-12(10)21(16,18)19/h6-8H,1-5H2,(H2,15,17)(H2,16,18,19) AUMZYYXDKOTCJB-UHFFFAOYSA-N 50504939 CHEMBL4586089 Carbonic anhydrase 4 Homo sapiens 170 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504939&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155566763 440713524 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231285 NS(=O)(=O)c1cc(C(=O)NCCO)c(Cl)cc1Cl InChI=1S/C9H10Cl2N2O4S/c10-6-4-7(11)8(18(12,16)17)3-5(6)9(15)13-1-2-14/h3-4,14H,1-2H2,(H,13,15)(H2,12,16,17) UISZEPPPNAJTCZ-UHFFFAOYSA-N 50449831 CHEMBL4172331 Carbonic anhydrase 4 Homo sapiens 400 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449831&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12698192 433919393 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231286 NS(=O)(=O)c1cc(C(=O)NCCO)c(SCc2ccccc2)cc1Cl InChI=1S/C16H17ClN2O4S2/c17-13-9-14(24-10-11-4-2-1-3-5-11)12(16(21)19-6-7-20)8-15(13)25(18,22)23/h1-5,8-9,20H,6-7,10H2,(H,19,21)(H2,18,22,23) VVGWLEPPAHMEIE-UHFFFAOYSA-N 50504951 CHEMBL4565224 Carbonic anhydrase 4 Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504951&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508707 440713536 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231287 NS(=O)(=O)c1cc(C(=O)NCCCO)c(Cl)cc1Cl InChI=1S/C10H12Cl2N2O4S/c11-7-5-8(12)9(19(13,17)18)4-6(7)10(16)14-2-1-3-15/h4-5,15H,1-3H2,(H,14,16)(H2,13,17,18) OZBGWVAREHIEDY-UHFFFAOYSA-N 50449827 CHEMBL4173471 Carbonic anhydrase 4 Homo sapiens 7.1 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449827&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508709 433919389 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231288 NS(=O)(=O)c1cc(C(=O)NCCCO)c(SC2CCCCC2)cc1Cl InChI=1S/C16H23ClN2O4S2/c17-13-10-14(24-11-5-2-1-3-6-11)12(9-15(13)25(18,22)23)16(21)19-7-4-8-20/h9-11,20H,1-8H2,(H,19,21)(H2,18,22,23) JUVRPCRQYSAHSW-UHFFFAOYSA-N 50504940 CHEMBL4475073 Carbonic anhydrase 4 Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504940&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508603 440713525 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231289 CCCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C11H14Cl2N2O3S/c1-2-3-4-15-11(16)7-5-10(19(14,17)18)9(13)6-8(7)12/h5-6H,2-4H2,1H3,(H,15,16)(H2,14,17,18) KRIUYRKSVUBELV-UHFFFAOYSA-N 50449816 CHEMBL4160149 Carbonic anhydrase 4 Homo sapiens 83 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449816&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ENN 6G5U,6G6T 34852311 433919379 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231290 CCCCNC(=O)c1cc(c(Cl)cc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C17H19ClN2O3S2/c1-2-3-9-20-17(21)13-10-16(25(19,22)23)14(18)11-15(13)24-12-7-5-4-6-8-12/h4-8,10-11H,2-3,9H2,1H3,(H,20,21)(H2,19,22,23) LHVJYOYHQKRYSI-UHFFFAOYSA-N 50504900 CHEMBL4574321 Carbonic anhydrase 4 Homo sapiens 2.0 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504900&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508306 440713485 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231291 COCCNC(=O)c1cc(c(Cl)cc1SC1CCCCC1)S(N)(=O)=O InChI=1S/C16H23ClN2O4S2/c1-23-8-7-19-16(20)12-9-15(25(18,21)22)13(17)10-14(12)24-11-5-3-2-4-6-11/h9-11H,2-8H2,1H3,(H,19,20)(H2,18,21,22) XGTJWUIMMWSYOY-UHFFFAOYSA-N 50504909 CHEMBL4450456 Carbonic anhydrase 4 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504909&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508781 440713494 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231292 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C12H14Cl2N2O5S/c1-21-11(17)3-2-4-16-12(18)7-5-10(22(15,19)20)9(14)6-8(7)13/h5-6H,2-4H2,1H3,(H,16,18)(H2,15,19,20) HPOYDHZZGCZYRF-UHFFFAOYSA-N 50449818 CHEMBL4165896 Carbonic anhydrase 4 Homo sapiens 110 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449818&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508879 433919381 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231293 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1SC1CCCCC1)S(N)(=O)=O InChI=1S/C18H25ClN2O5S2/c1-26-17(22)8-5-9-21-18(23)13-10-16(28(20,24)25)14(19)11-15(13)27-12-6-3-2-4-7-12/h10-12H,2-9H2,1H3,(H,21,23)(H2,20,24,25) AUBRGAXHAIBSRT-UHFFFAOYSA-N 50504896 CHEMBL4588838 Carbonic anhydrase 4 Homo sapiens 96 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504896&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search J92 6QNL,6QN2 126508837 440713481 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231294 NS(=O)(=O)c1cc(C(=O)N2CCOCC2)c(Sc2ccccc2)cc1Cl InChI=1S/C17H17ClN2O4S2/c18-14-11-15(25-12-4-2-1-3-5-12)13(10-16(14)26(19,22)23)17(21)20-6-8-24-9-7-20/h1-5,10-11H,6-9H2,(H2,19,22,23) KCHKZYKQHJUTFV-UHFFFAOYSA-N 50504945 CHEMBL4579206 Carbonic anhydrase 4 Homo sapiens 2900 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504945&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507944 440713530 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231295 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(Cl)cc1Cl InChI=1S/C13H16Cl2N2O3S/c14-10-7-11(15)12(21(16,19)20)6-9(10)13(18)17-8-4-2-1-3-5-8/h6-8H,1-5H2,(H,17,18)(H2,16,19,20) FYPYZSIHTPQQDJ-UHFFFAOYSA-N 50449834 CHEMBL4173501 Carbonic anhydrase 4 Homo sapiens 170 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449834&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 60635034 433919396 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231296 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(SC2CCCCC2)cc1Cl InChI=1S/C19H27ClN2O3S2/c20-16-12-17(26-14-9-5-2-6-10-14)15(11-18(16)27(21,24)25)19(23)22-13-7-3-1-4-8-13/h11-14H,1-10H2,(H,22,23)(H2,21,24,25) NLYBQJCQXDIDRT-UHFFFAOYSA-N 50504929 CHEMBL4551069 Carbonic anhydrase 4 Homo sapiens 100 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504929&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509146 440713514 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231297 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(SCc2ccccc2)cc1Cl InChI=1S/C20H23ClN2O3S2/c21-17-12-18(27-13-14-7-3-1-4-8-14)16(11-19(17)28(22,25)26)20(24)23-15-9-5-2-6-10-15/h1,3-4,7-8,11-12,15H,2,5-6,9-10,13H2,(H,23,24)(H2,22,25,26) ZUCBUUIASYMKCB-UHFFFAOYSA-N 50504935 CHEMBL4451503 Carbonic anhydrase 4 Homo sapiens 180 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504935&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508387 440713520 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231298 NS(=O)(=O)c1cc(C(=O)NCCO)c(Br)cc1Br InChI=1S/C9H10Br2N2O4S/c10-6-4-7(11)8(18(12,16)17)3-5(6)9(15)13-1-2-14/h3-4,14H,1-2H2,(H,13,15)(H2,12,16,17) FASQQHIRLIBRPZ-UHFFFAOYSA-N 50449809 CHEMBL4168997 Carbonic anhydrase 4 Homo sapiens 110 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449809&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509027 433919372 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231299 NS(=O)(=O)c1cc(C(=O)NCCO)c(Sc2ccccc2)cc1Br InChI=1S/C15H15BrN2O4S2/c16-12-9-13(23-10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)24(17,21)22/h1-5,8-9,19H,6-7H2,(H,18,20)(H2,17,21,22) PRYBEVSATZDKFU-UHFFFAOYSA-N 50504954 CHEMBL4593681 Carbonic anhydrase 4 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504954&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508295 440713539 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231300 NS(=O)(=O)c1cc(C(=O)NCCO)c(SC2CCCCC2)cc1Br InChI=1S/C15H21BrN2O4S2/c16-12-9-13(23-10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)24(17,21)22/h8-10,19H,1-7H2,(H,18,20)(H2,17,21,22) MOQPYUBNCWCUAP-UHFFFAOYSA-N 50504933 CHEMBL4539233 Carbonic anhydrase 4 Homo sapiens 61 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504933&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508088 440713518 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231301 NS(=O)(=O)c1cc(C(=O)NCCO)c(SCCc2ccccc2)cc1Br InChI=1S/C17H19BrN2O4S2/c18-14-11-15(25-9-6-12-4-2-1-3-5-12)13(17(22)20-7-8-21)10-16(14)26(19,23)24/h1-5,10-11,21H,6-9H2,(H,20,22)(H2,19,23,24) XWTWKKFMRZDTAA-UHFFFAOYSA-N 50504930 CHEMBL4515586 Carbonic anhydrase 4 Homo sapiens 170 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504930&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507682 440713515 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231302 CCCCNC(=O)c1cc(c(Br)cc1Br)S(N)(=O)=O InChI=1S/C11H14Br2N2O3S/c1-2-3-4-15-11(16)7-5-10(19(14,17)18)9(13)6-8(7)12/h5-6H,2-4H2,1H3,(H,15,16)(H2,14,17,18) QKIXSEIIKHMOKR-UHFFFAOYSA-N 50449836 CHEMBL4166643 Carbonic anhydrase 4 Homo sapiens 50 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449836&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509349 433919398 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231303 CCCCNC(=O)c1cc(c(Br)cc1SCc1ccccc1)S(N)(=O)=O InChI=1S/C18H21BrN2O3S2/c1-2-3-9-21-18(22)14-10-17(26(20,23)24)15(19)11-16(14)25-12-13-7-5-4-6-8-13/h4-8,10-11H,2-3,9,12H2,1H3,(H,21,22)(H2,20,23,24) SVSTVNXTRFJTAJ-UHFFFAOYSA-N 50504913 CHEMBL4436290 Carbonic anhydrase 4 Homo sapiens 25 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504913&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508116 440713498 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231304 CCCCNC(=O)c1cc(c(Br)cc1SCCO)S(N)(=O)=O InChI=1S/C13H19BrN2O4S2/c1-2-3-4-16-13(18)9-7-12(22(15,19)20)10(14)8-11(9)21-6-5-17/h7-8,17H,2-6H2,1H3,(H,16,18)(H2,15,19,20) YEPSGVPRNAGLAA-UHFFFAOYSA-N 50504942 CHEMBL4521683 Carbonic anhydrase 4 Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504942&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508178 440713527 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231305 CC(=O)OCCCNC(=O)c1cc(c(Cl)cc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C18H19ClN2O5S2/c1-12(22)26-9-5-8-21-18(23)14-10-17(28(20,24)25)15(19)11-16(14)27-13-6-3-2-4-7-13/h2-4,6-7,10-11H,5,8-9H2,1H3,(H,21,23)(H2,20,24,25) XMVRIQFKEVJZEP-UHFFFAOYSA-N 50504934 CHEMBL4565560 Carbonic anhydrase 4 Homo sapiens 2.9 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504934&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126506968 440713519 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231306 NS(=O)(=O)c1cc(C(=O)NCCO)c(cc1Cl)S(=O)(=O)c1ccccc1 InChI=1S/C15H15ClN2O6S2/c16-12-9-13(25(21,22)10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)26(17,23)24/h1-5,8-9,19H,6-7H2,(H,18,20)(H2,17,23,24) KLUHDZWPAPUVIW-UHFFFAOYSA-N 50504953 CHEMBL4443095 Carbonic anhydrase 4 Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504953&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search JTW 6R6J,6R71 126509224 440713538 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231307 NS(=O)(=O)c1cc(C(=O)NCCO)c(cc1Cl)S(=O)(=O)Cc1ccccc1 InChI=1S/C16H17ClN2O6S2/c17-13-9-14(26(22,23)10-11-4-2-1-3-5-11)12(16(21)19-6-7-20)8-15(13)27(18,24)25/h1-5,8-9,20H,6-7,10H2,(H,19,21)(H2,18,24,25) KZUKWKADTYXYMJ-UHFFFAOYSA-N 50504901 CHEMBL4441901 Carbonic anhydrase 4 Homo sapiens 250 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504901&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507400 440713486 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228745 Cc1c(nnn1-c1ccc(cc1)S(N)(=O)=O)-c1nnc(SCC(=O)c2cccc(c2)[N+]([O-])=O)[nH]1 InChI=1S/C19H16N8O5S2/c1-11-17(22-25-26(11)13-5-7-15(8-6-13)34(20,31)32)18-21-19(24-23-18)33-10-16(28)12-3-2-4-14(9-12)27(29)30/h2-9H,10H2,1H3,(H2,20,31,32)(H,21,23,24) WMTIQKFLIVPNQY-UHFFFAOYSA-N 50504229 CHEMBL4561998 Carbonic anhydrase 4 Homo sapiens 128 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504229&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155558990 440712814 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228746 Cc1c(nnn1-c1ccc(cc1)S(N)(=O)=O)-c1n[nH]c(=S)[nH]1 InChI=1S/C11H11N7O2S2/c1-6-9(10-13-11(21)16-15-10)14-17-18(6)7-2-4-8(5-3-7)22(12,19)20/h2-5H,1H3,(H2,12,19,20)(H2,13,15,16,21) KSQJIDABRGZHPW-UHFFFAOYSA-N 50504230 CHEMBL4438713 Carbonic anhydrase 4 Homo sapiens 1005 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504230&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155513169 440712815 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228751 NS(=O)(=O)c1ccc(cc1)-n1nnc(-c2nnc(SCC(=O)c3cccc(c3)[N+]([O-])=O)[nH]2)c1-c1ccccc1 InChI=1S/C24H18N8O5S2/c25-39(36,37)19-11-9-17(10-12-19)31-22(15-5-2-1-3-6-15)21(27-30-31)23-26-24(29-28-23)38-14-20(33)16-7-4-8-18(13-16)32(34)35/h1-13H,14H2,(H2,25,36,37)(H,26,28,29) SJGHUFXEZLWHPL-UHFFFAOYSA-N 50504234 CHEMBL4434892 Carbonic anhydrase 4 Homo sapiens 4.5 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504234&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155510831 440712819 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228765 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228766 NS(=O)(=O)c1ccc(cc1)-n1nnc(-c2nnc(SCC(=O)c3cccc(Br)c3)[nH]2)c1-c1ccccc1 InChI=1S/C24H18BrN7O3S2/c25-17-8-4-7-16(13-17)20(33)14-36-24-27-23(29-30-24)21-22(15-5-2-1-3-6-15)32(31-28-21)18-9-11-19(12-10-18)37(26,34)35/h1-13H,14H2,(H2,26,34,35)(H,27,29,30) ZOSQVAAEXVGULL-UHFFFAOYSA-N 50504244 CHEMBL4445271 Carbonic anhydrase 4 Homo sapiens 21 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504244&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155517933 440712829 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228767 NS(=O)(=O)c1ccc(cc1)-n1nnc(-c2nnc(SCC(=O)c3ccc(Br)cc3)[nH]2)c1-c1ccccc1 InChI=1S/C24H18BrN7O3S2/c25-17-8-6-15(7-9-17)20(33)14-36-24-27-23(29-30-24)21-22(16-4-2-1-3-5-16)32(31-28-21)18-10-12-19(13-11-18)37(26,34)35/h1-13H,14H2,(H2,26,34,35)(H,27,29,30) IFMKIYAEAJYEFB-UHFFFAOYSA-N 50504228 CHEMBL4437281 Carbonic anhydrase 4 Homo sapiens 38 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504228&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155512418 440712813 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228768 NS(=O)(=O)c1ccc(cc1)-n1nnc(-c2nnc(SCC(=O)c3ccc(F)cc3)[nH]2)c1-c1ccccc1 InChI=1S/C24H18FN7O3S2/c25-17-8-6-15(7-9-17)20(33)14-36-24-27-23(29-30-24)21-22(16-4-2-1-3-5-16)32(31-28-21)18-10-12-19(13-11-18)37(26,34)35/h1-13H,14H2,(H2,26,34,35)(H,27,29,30) HBLHNVJAWVVDJO-UHFFFAOYSA-N 50504236 CHEMBL4537993 Carbonic anhydrase 4 Homo sapiens 4.8 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504236&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155548911 440712821 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228769 Cc1ccc(cc1)C(=O)CSc1nnc([nH]1)-c1nnn(c1-c1ccccc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C25H21N7O3S2/c1-16-7-9-17(10-8-16)21(33)15-36-25-27-24(29-30-25)22-23(18-5-3-2-4-6-18)32(31-28-22)19-11-13-20(14-12-19)37(26,34)35/h2-14H,15H2,1H3,(H2,26,34,35)(H,27,29,30) HOPVSRNSCNPCBX-UHFFFAOYSA-N 50504237 CHEMBL4454775 Carbonic anhydrase 4 Homo sapiens 43 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504237&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155523857 440712822 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228770 Cc1c(nnn1-c1ccc(cc1)S(N)(=O)=O)-c1nnc(SCC(=O)c2cccc(Br)c2)[nH]1 InChI=1S/C19H16BrN7O3S2/c1-11-17(23-26-27(11)14-5-7-15(8-6-14)32(21,29)30)18-22-19(25-24-18)31-10-16(28)12-3-2-4-13(20)9-12/h2-9H,10H2,1H3,(H2,21,29,30)(H,22,24,25) FYHLJSVMHYCZLW-UHFFFAOYSA-N 50504239 CHEMBL4588654 Carbonic anhydrase 4 Homo sapiens 1909 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504239&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155567991 440712824 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228771 Cc1c(nnn1-c1ccc(cc1)S(N)(=O)=O)-c1nnc(SCC(=O)c2ccc(cc2)[N+]([O-])=O)[nH]1 InChI=1S/C19H16N8O5S2/c1-11-17(22-25-26(11)13-6-8-15(9-7-13)34(20,31)32)18-21-19(24-23-18)33-10-16(28)12-2-4-14(5-3-12)27(29)30/h2-9H,10H2,1H3,(H2,20,31,32)(H,21,23,24) ZIPHZORDFGMXFU-UHFFFAOYSA-N 50504240 CHEMBL4591297 Carbonic anhydrase 4 Homo sapiens 1809 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504240&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155568274 440712825 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228772 Cc1c(nnn1-c1ccc(cc1)S(N)(=O)=O)-c1nnc(SCC(=O)c2ccc(Br)cc2)[nH]1 InChI=1S/C19H16BrN7O3S2/c1-11-17(23-26-27(11)14-6-8-15(9-7-14)32(21,29)30)18-22-19(25-24-18)31-10-16(28)12-2-4-13(20)5-3-12/h2-9H,10H2,1H3,(H2,21,29,30)(H,22,24,25) XLWKJSIPIWJALQ-UHFFFAOYSA-N 50504245 CHEMBL4469524 Carbonic anhydrase 4 Homo sapiens 2958 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504245&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155533898 440712830 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228773 Cc1c(nnn1-c1ccc(cc1)S(N)(=O)=O)-c1nnc(SCC(=O)c2ccc(C)cc2)[nH]1 InChI=1S/C20H19N7O3S2/c1-12-3-5-14(6-4-12)17(28)11-31-20-22-19(24-25-20)18-13(2)27(26-23-18)15-7-9-16(10-8-15)32(21,29)30/h3-10H,11H2,1-2H3,(H2,21,29,30)(H,22,24,25) ZXFVFHTWNPGBRP-UHFFFAOYSA-N 50504227 CHEMBL4584974 Carbonic anhydrase 4 Homo sapiens 4666 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504227&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155561839 440712812 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228774 Cc1c(nnn1-c1ccc(cc1)S(N)(=O)=O)-c1nnc(SCC(=O)c2ccccc2)[nH]1 InChI=1S/C19H17N7O3S2/c1-12-17(22-25-26(12)14-7-9-15(10-8-14)31(20,28)29)18-21-19(24-23-18)30-11-16(27)13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H2,20,28,29)(H,21,23,24) HAPZIFGHFJJEHY-UHFFFAOYSA-N 50504242 CHEMBL4584854 Carbonic anhydrase 4 Homo sapiens 4338 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504242&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155561751 440712827 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228775 NC(=S)NNC(=O)c1nnn(c1-c1ccccc1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H15N7O3S2/c17-16(27)21-20-15(24)13-14(10-4-2-1-3-5-10)23(22-19-13)11-6-8-12(9-7-11)28(18,25)26/h1-9H,(H,20,24)(H3,17,21,27)(H2,18,25,26) IJNYRONYFPZPKF-UHFFFAOYSA-N 50504243 CHEMBL4551813 Carbonic anhydrase 4 Homo sapiens 226 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504243&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155555803 440712828 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228776 Cc1c(nnn1-c1ccc(cc1)S(N)(=O)=O)C(=O)NNC(N)=S InChI=1S/C11H13N7O3S2/c1-6-9(10(19)15-16-11(12)22)14-17-18(6)7-2-4-8(5-3-7)23(13,20)21/h2-5H,1H3,(H,15,19)(H3,12,16,22)(H2,13,20,21) VTDPDGHUGBKQSI-UHFFFAOYSA-N 50504246 CHEMBL4539327 Carbonic anhydrase 4 Homo sapiens 4612 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504246&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155550099 440712831 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228805 NS(=O)(=O)c1ccc(cc1)-n1nnc(-c2nnc(SCC(=O)c3ccc(Cl)cc3)[nH]2)c1-c1ccccc1 InChI=1S/C24H18ClN7O3S2/c25-17-8-6-15(7-9-17)20(33)14-36-24-27-23(29-30-24)21-22(16-4-2-1-3-5-16)32(31-28-21)18-10-12-19(13-11-18)37(26,34)35/h1-13H,14H2,(H2,26,34,35)(H,27,29,30) DAEHMXOKAGDXMD-UHFFFAOYSA-N 50504248 CHEMBL4449503 Carbonic anhydrase 4 Homo sapiens 112 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504248&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155520792 440712833 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228806 NS(=O)(=O)c1ccc(cc1)-n1nnc(-c2nnc(SCC(=O)c3ccccc3)[nH]2)c1-c1ccccc1 InChI=1S/C24H19N7O3S2/c25-36(33,34)19-13-11-18(12-14-19)31-22(17-9-5-2-6-10-17)21(27-30-31)23-26-24(29-28-23)35-15-20(32)16-7-3-1-4-8-16/h1-14H,15H2,(H2,25,33,34)(H,26,28,29) YLFKKSPVDBHVJQ-UHFFFAOYSA-N 50504238 CHEMBL4555368 Carbonic anhydrase 4 Homo sapiens 62 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504238&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155556761 440712823 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228807 Cc1c(nnn1-c1ccc(cc1)S(N)(=O)=O)-c1nnc(SCC(=O)c2ccc(Cl)cc2)[nH]1 InChI=1S/C19H16ClN7O3S2/c1-11-17(23-26-27(11)14-6-8-15(9-7-14)32(21,29)30)18-22-19(25-24-18)31-10-16(28)12-2-4-13(20)5-3-12/h2-9H,10H2,1H3,(H2,21,29,30)(H,22,24,25) KPDNFDCZIGGANW-UHFFFAOYSA-N 50504232 CHEMBL4590611 Carbonic anhydrase 4 Homo sapiens 4307 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504232&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155567981 440712817 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228808 NS(=O)(=O)c1ccc(cc1)-n1nnc(-c2n[nH]c(=S)[nH]2)c1-c1ccccc1 InChI=1S/C16H13N7O2S2/c17-27(24,25)12-8-6-11(7-9-12)23-14(10-4-2-1-3-5-10)13(19-22-23)15-18-16(26)21-20-15/h1-9H,(H2,17,24,25)(H2,18,20,21,26) WOJVROUEEGRTEA-UHFFFAOYSA-N 50504247 CHEMBL4463810 Carbonic anhydrase 4 Homo sapiens 46 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504247&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155530326 440712832 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231425 CCCCNC(=O)c1cc(c(Cl)cc1S(=O)(=O)c1ccccc1)S(N)(=O)=O InChI=1S/C17H19ClN2O5S2/c1-2-3-9-20-17(21)13-10-16(27(19,24)25)14(18)11-15(13)26(22,23)12-7-5-4-6-8-12/h4-8,10-11H,2-3,9H2,1H3,(H,20,21)(H2,19,24,25) HNGWBCPNEWJHHT-UHFFFAOYSA-N 50504943 CHEMBL4583164 Carbonic anhydrase 4 Homo sapiens 17 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504943&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509299 440713528 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231426 COCCNC(=O)c1cc(c(Cl)cc1S(=O)(=O)c1ccccc1)S(N)(=O)=O InChI=1S/C16H17ClN2O6S2/c1-25-8-7-19-16(20)12-9-15(27(18,23)24)13(17)10-14(12)26(21,22)11-5-3-2-4-6-11/h2-6,9-10H,7-8H2,1H3,(H,19,20)(H2,18,23,24) PCIBFBDEVBBIFN-UHFFFAOYSA-N 50504928 CHEMBL4592616 Carbonic anhydrase 4 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504928&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507863 440713513 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231427 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1S(=O)(=O)C1CCCCC1)S(N)(=O)=O InChI=1S/C18H25ClN2O7S2/c1-28-17(22)8-5-9-21-18(23)13-10-16(30(20,26)27)14(19)11-15(13)29(24,25)12-6-3-2-4-7-12/h10-12H,2-9H2,1H3,(H,21,23)(H2,20,26,27) OJCBLUGIJDOTFF-UHFFFAOYSA-N 50504921 CHEMBL4514121 Carbonic anhydrase 4 Homo sapiens 110 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504921&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509247 440713506 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231428 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(cc1Cl)S(=O)(=O)c1ccccc1 InChI=1S/C19H21ClN2O5S2/c20-16-12-17(28(24,25)14-9-5-2-6-10-14)15(11-18(16)29(21,26)27)19(23)22-13-7-3-1-4-8-13/h2,5-6,9-13H,1,3-4,7-8H2,(H,22,23)(H2,21,26,27) VCTHPGGSJKHJDI-UHFFFAOYSA-N 50504902 CHEMBL4466735 Carbonic anhydrase 4 Homo sapiens 90 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504902&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509291 440713487 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231429 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(cc1Cl)S(=O)(=O)Cc1ccccc1 InChI=1S/C20H23ClN2O5S2/c21-17-12-18(29(25,26)13-14-7-3-1-4-8-14)16(11-19(17)30(22,27)28)20(24)23-15-9-5-2-6-10-15/h1,3-4,7-8,11-12,15H,2,5-6,9-10,13H2,(H,23,24)(H2,22,27,28) YZJMQWTUVKKLNZ-UHFFFAOYSA-N 50504907 CHEMBL4529297 Carbonic anhydrase 4 Homo sapiens 2100 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504907&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509170 440713492 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231430 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(cc1Cl)S(=O)(=O)CCO InChI=1S/C15H21ClN2O6S2/c16-12-9-13(25(21,22)7-6-19)11(8-14(12)26(17,23)24)15(20)18-10-4-2-1-3-5-10/h8-10,19H,1-7H2,(H,18,20)(H2,17,23,24) WEOFIRPZWSUJBC-UHFFFAOYSA-N 50504955 CHEMBL4549561 Carbonic anhydrase 4 Homo sapiens 1100 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504955&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507192 440713540 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231431 NS(=O)(=O)c1cc(C(=O)NCc2ccccc2)c(cc1Cl)S(=O)(=O)C1CCCCC1 InChI=1S/C20H23ClN2O5S2/c21-17-12-18(29(25,26)15-9-5-2-6-10-15)16(11-19(17)30(22,27)28)20(24)23-13-14-7-3-1-4-8-14/h1,3-4,7-8,11-12,15H,2,5-6,9-10,13H2,(H,23,24)(H2,22,27,28) ICDSIUVYLWJHJY-UHFFFAOYSA-N 50504950 CHEMBL4573963 Carbonic anhydrase 4 Homo sapiens 220 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504950&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508608 440713535 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231432 NS(=O)(=O)c1cc(C(=O)NCCO)c(cc1Br)S(=O)(=O)Cc1ccccc1 InChI=1S/C16H17BrN2O6S2/c17-13-9-14(26(22,23)10-11-4-2-1-3-5-11)12(16(21)19-6-7-20)8-15(13)27(18,24)25/h1-5,8-9,20H,6-7,10H2,(H,19,21)(H2,18,24,25) PYLVVDNHUGVMGF-UHFFFAOYSA-N 50504918 CHEMBL4513913 Carbonic anhydrase 4 Homo sapiens 1100 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504918&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509348 440713503 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231433 CCCCNC(=O)c1cc(c(Br)cc1S(=O)(=O)C1CCCCC1)S(N)(=O)=O InChI=1S/C17H25BrN2O5S2/c1-2-3-9-20-17(21)13-10-16(27(19,24)25)14(18)11-15(13)26(22,23)12-7-5-4-6-8-12/h10-12H,2-9H2,1H3,(H,20,21)(H2,19,24,25) ADZJIEUIYRWVJN-UHFFFAOYSA-N 50504903 CHEMBL4454599 Carbonic anhydrase 4 Homo sapiens 110 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504903&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508968 440713488 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231434 NS(=O)(=O)c1cc(C(=O)NCCO)c(cc1Br)[S+]([O-])c1ccccc1 InChI=1S/C15H15BrN2O5S2/c16-12-9-13(24(21)10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)25(17,22)23/h1-5,8-9,19H,6-7H2,(H,18,20)(H2,17,22,23) WMAKPMGOFNHAFL-UHFFFAOYSA-N 50504908 CHEMBL4566236 Carbonic anhydrase 4 Homo sapiens 84 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504908&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508486 440713493 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231435 NS(=O)(=O)c1cc(C(=O)NCCCC(O)=O)c(Cl)cc1Cl InChI=1S/C11H12Cl2N2O5S/c12-7-5-8(13)9(21(14,19)20)4-6(7)11(18)15-3-1-2-10(16)17/h4-5H,1-3H2,(H,15,18)(H,16,17)(H2,14,19,20) AZHHAHHRNOQVSO-UHFFFAOYSA-N 50449821 CHEMBL4168586 Carbonic anhydrase 4 Homo sapiens 280 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449821&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508712 433919384 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231436 NS(=O)(=O)c1cc(C(=O)NCCCC(O)=O)c(cc1Cl)S(=O)(=O)Cc1ccccc1 InChI=1S/C18H19ClN2O7S2/c19-14-10-15(29(25,26)11-12-5-2-1-3-6-12)13(9-16(14)30(20,27)28)18(24)21-8-4-7-17(22)23/h1-3,5-6,9-10H,4,7-8,11H2,(H,21,24)(H,22,23)(H2,20,27,28) DZABBYYPQHZLHW-UHFFFAOYSA-N 50504910 CHEMBL4472135 Carbonic anhydrase 4 Homo sapiens 1900 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504910&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507792 440713495 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228821 NS(=O)(=O)c1ccc(cc1)-n1nnc(-c2nnc(SCC(=O)c3ccc(cc3)-c3ccccc3)[nH]2)c1-c1ccccc1 InChI=1S/C30H23N7O3S2/c31-42(39,40)25-17-15-24(16-18-25)37-28(23-9-5-2-6-10-23)27(33-36-37)29-32-30(35-34-29)41-19-26(38)22-13-11-21(12-14-22)20-7-3-1-4-8-20/h1-18H,19H2,(H2,31,39,40)(H,32,34,35) XFJBHEGTIUXDRM-UHFFFAOYSA-N 50504231 CHEMBL4555440 Carbonic anhydrase 4 Homo sapiens 303 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504231&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155557329 440712816 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228822 Cc1c(nnn1-c1ccc(cc1)S(N)(=O)=O)-c1nnc(SCC(=O)c2ccc(F)cc2)[nH]1 InChI=1S/C19H16FN7O3S2/c1-11-17(23-26-27(11)14-6-8-15(9-7-14)32(21,29)30)18-22-19(25-24-18)31-10-16(28)12-2-4-13(20)5-3-12/h2-9H,10H2,1H3,(H2,21,29,30)(H,22,24,25) ZFRREGSGZGAQLH-UHFFFAOYSA-N 50504233 CHEMBL4522179 Carbonic anhydrase 4 Homo sapiens 2004 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504233&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155542934 440712818 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228828 NS(=O)(=O)c1ccc(cc1)-n1nnc(-c2nnc(SCC(=O)c3ccc(cc3)[N+]([O-])=O)[nH]2)c1-c1ccccc1 InChI=1S/C24H18N8O5S2/c25-39(36,37)19-12-10-17(11-13-19)31-22(16-4-2-1-3-5-16)21(27-30-31)23-26-24(29-28-23)38-14-20(33)15-6-8-18(9-7-15)32(34)35/h1-13H,14H2,(H2,25,36,37)(H,26,28,29) OEJCXCPFCKRVSJ-UHFFFAOYSA-N 50504235 CHEMBL4437653 Carbonic anhydrase 4 Homo sapiens 42 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504235&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155512706 440712820 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51228829 Cc1c(nnn1-c1ccc(cc1)S(N)(=O)=O)-c1nnc(SCC(=O)c2ccc(cc2)-c2ccccc2)[nH]1 InChI=1S/C25H21N7O3S2/c1-16-23(28-31-32(16)20-11-13-21(14-12-20)37(26,34)35)24-27-25(30-29-24)36-15-22(33)19-9-7-18(8-10-19)17-5-3-2-4-6-17/h2-14H,15H2,1H3,(H2,26,34,35)(H,27,29,30) OBLWRMHNPVGEIS-UHFFFAOYSA-N 50504241 CHEMBL4446666 Carbonic anhydrase 4 Homo sapiens 64 ChEMBL 10.1016/j.ejmech.2019.111698 10.7270/Q2F1930N 31539777 Vats, L; Kumar, R; Bua, S; Nocentini, A; Gratteri, P; Supuran, CT; Sharma, PK Kurukshetra University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504241&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155518807 440712826 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230400 NS(=O)(=O)c1cc(C(=O)N2CCOCC2)c(Cl)cc1Cl InChI=1S/C11H12Cl2N2O4S/c12-8-6-9(13)10(20(14,17)18)5-7(8)11(16)15-1-3-19-4-2-15/h5-6H,1-4H2,(H2,14,17,18) AVTRWXCLWDQMCF-UHFFFAOYSA-N 50449830 CHEMBL4173814 Carbonic anhydrase 4 Homo sapiens 330 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449830&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 60635890 433919392 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230401 NS(=O)(=O)c1cc(C(=O)NCc2ccccc2)c(SC2CCCCC2)cc1Cl InChI=1S/C20H23ClN2O3S2/c21-17-12-18(27-15-9-5-2-6-10-15)16(11-19(17)28(22,25)26)20(24)23-13-14-7-3-1-4-8-14/h1,3-4,7-8,11-12,15H,2,5-6,9-10,13H2,(H,23,24)(H2,22,25,26) IHQUXGSVVLEKAV-UHFFFAOYSA-N 50504905 CHEMBL4442511 Carbonic anhydrase 4 Homo sapiens 86 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504905&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508912 440713490 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230402 CCCCNC(=O)c1cc(c(Br)cc1SCCc1ccccc1)S(N)(=O)=O InChI=1S/C19H23BrN2O3S2/c1-2-3-10-22-19(23)15-12-18(27(21,24)25)16(20)13-17(15)26-11-9-14-7-5-4-6-8-14/h4-8,12-13H,2-3,9-11H2,1H3,(H,22,23)(H2,21,24,25) AUUAQVXOSSGYPF-UHFFFAOYSA-N 50504906 CHEMBL4468834 Carbonic anhydrase 4 Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504906&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508271 440713491 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230407 NC(=O)c1cc(c(Cl)cc1SCCc1ccccc1)S(N)(=O)=O InChI=1S/C15H15ClN2O3S2/c16-12-9-13(22-7-6-10-4-2-1-3-5-10)11(15(17)19)8-14(12)23(18,20)21/h1-5,8-9H,6-7H2,(H2,17,19)(H2,18,20,21) YEZJTTVQWKXURB-UHFFFAOYSA-N 50504911 CHEMBL4456851 Carbonic anhydrase 4 Homo sapiens 100 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504911&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155526221 440713496 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230408 CCCCNC(=O)c1cc(c(Cl)cc1SC1CCCCC1)S(N)(=O)=O InChI=1S/C17H25ClN2O3S2/c1-2-3-9-20-17(21)13-10-16(25(19,22)23)14(18)11-15(13)24-12-7-5-4-6-8-12/h10-12H,2-9H2,1H3,(H,20,21)(H2,19,22,23) WZHPNNQXMINMAU-UHFFFAOYSA-N 50504912 CHEMBL4451500 Carbonic anhydrase 4 Homo sapiens 5.0 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504912&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509009 440713497 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230431 COCCNC(=O)c1cc(c(Cl)cc1S(=O)(=O)C1CCCCC1)S(N)(=O)=O InChI=1S/C16H23ClN2O6S2/c1-25-8-7-19-16(20)12-9-15(27(18,23)24)13(17)10-14(12)26(21,22)11-5-3-2-4-6-11/h9-11H,2-8H2,1H3,(H,19,20)(H2,18,23,24) HBFALEBDZRZUTP-UHFFFAOYSA-N 50504924 CHEMBL4579465 Carbonic anhydrase 4 Homo sapiens 50 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504924&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508465 440713509 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230432 NS(=O)(=O)c1cc(C(=O)NCCO)c(cc1Br)S(=O)(=O)C1CCCCC1 InChI=1S/C15H21BrN2O6S2/c16-12-9-13(25(21,22)10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)26(17,23)24/h8-10,19H,1-7H2,(H,18,20)(H2,17,23,24) KAMTXXAPTZNHJT-UHFFFAOYSA-N 50504925 CHEMBL4582964 Carbonic anhydrase 4 Homo sapiens 210 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504925&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508538 440713510 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230433 NS(=O)(=O)c1cc(C(=O)NCCCC(O)=O)c(SC2CCCCC2)cc1Cl InChI=1S/C17H23ClN2O5S2/c18-13-10-14(26-11-5-2-1-3-6-11)12(9-15(13)27(19,24)25)17(23)20-8-4-7-16(21)22/h9-11H,1-8H2,(H,20,23)(H,21,22)(H2,19,24,25) QBFWPSYDISFIKC-UHFFFAOYSA-N 50504904 CHEMBL4513684 Carbonic anhydrase 4 Homo sapiens 130 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504904&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508867 440713489 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231567 NS(=O)(=O)c1cc(C(=O)NCCO)c(SC2CCCCC2)cc1Cl InChI=1S/C15H21ClN2O4S2/c16-12-9-13(23-10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)24(17,21)22/h8-10,19H,1-7H2,(H,18,20)(H2,17,21,22) PSEDAEWMXCWYRT-UHFFFAOYSA-N 50504949 CHEMBL4450545 Carbonic anhydrase 4 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504949&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search EA3 6R6Y,6R6F 126508406 440713534 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231568 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1SCc1ccccc1)S(N)(=O)=O InChI=1S/C19H21ClN2O5S2/c1-27-18(23)8-5-9-22-19(24)14-10-17(29(21,25)26)15(20)11-16(14)28-12-13-6-3-2-4-7-13/h2-4,6-7,10-11H,5,8-9,12H2,1H3,(H,22,24)(H2,21,25,26) CPFIGMBLLZNRDF-UHFFFAOYSA-N 50504917 CHEMBL4572161 Carbonic anhydrase 4 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504917&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507693 440713502 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231569 NS(=O)(=O)c1cc(C(=O)NCc2ccccc2)c(Cl)cc1Cl InChI=1S/C14H12Cl2N2O3S/c15-11-7-12(16)13(22(17,20)21)6-10(11)14(19)18-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,18,19)(H2,17,20,21) RJDMKEUKPUTKRX-UHFFFAOYSA-N 50449819 CHEMBL4165570 Carbonic anhydrase 4 Homo sapiens 22 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449819&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507182 433919382 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231570 NS(=O)(=O)c1cc(C(=O)NCCO)c(cc1Cl)S(=O)(=O)C1CCCCC1 InChI=1S/C15H21ClN2O6S2/c16-12-9-13(25(21,22)10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)26(17,23)24/h8-10,19H,1-7H2,(H,18,20)(H2,17,23,24) XESFZDLAWXFOQS-UHFFFAOYSA-N 50504920 CHEMBL4459385 Carbonic anhydrase 4 Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504920&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508714 440713505 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231601 NS(=O)(=O)c1cc(C(O)=O)c(SC2CCCCC2)cc1Cl InChI=1S/C13H16ClNO4S2/c14-10-7-11(20-8-4-2-1-3-5-8)9(13(16)17)6-12(10)21(15,18)19/h6-8H,1-5H2,(H,16,17)(H2,15,18,19) RKWDVSIOPVQNEF-UHFFFAOYSA-N 50504959 CHEMBL4543024 Carbonic anhydrase 4 Homo sapiens 0.370000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504959&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155551734 440713544 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231602 NS(=O)(=O)c1cc(C(=O)NCCO)c(Sc2ccccc2)cc1Cl InChI=1S/C15H15ClN2O4S2/c16-12-9-13(23-10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)24(17,21)22/h1-5,8-9,19H,6-7H2,(H,18,20)(H2,17,21,22) XRTYWFQPSHFDQI-UHFFFAOYSA-N 50504944 CHEMBL4553519 Carbonic anhydrase 4 Homo sapiens 0.004000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504944&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507415 440713529 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231603 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1SC1CCCCC1)S(N)(=O)=O InChI=1S/C18H25ClN2O5S2/c1-26-17(22)8-5-9-21-18(23)13-10-16(28(20,24)25)14(19)11-15(13)27-12-6-3-2-4-7-12/h10-12H,2-9H2,1H3,(H,21,23)(H2,20,24,25) AUBRGAXHAIBSRT-UHFFFAOYSA-N 50504896 CHEMBL4588838 Carbonic anhydrase 4 Homo sapiens 0.260000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504896&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search J92 6QNL,6QN2 126508837 440713481 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231604 NS(=O)(=O)c1cc(C(=O)NCc2ccccc2)c(Cl)cc1Cl InChI=1S/C14H12Cl2N2O3S/c15-11-7-12(16)13(22(17,20)21)6-10(11)14(19)18-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,18,19)(H2,17,20,21) RJDMKEUKPUTKRX-UHFFFAOYSA-N 50449819 CHEMBL4165570 Carbonic anhydrase 4 Homo sapiens 0.090000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449819&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507182 433919382 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231605 CCCCNC(=O)c1cc(c(Cl)cc1S(=O)(=O)C1CCCCC1)S(N)(=O)=O InChI=1S/C17H25ClN2O5S2/c1-2-3-9-20-17(21)13-10-16(27(19,24)25)14(18)11-15(13)26(22,23)12-7-5-4-6-8-12/h10-12H,2-9H2,1H3,(H,20,21)(H2,19,24,25) GUEMGVWYVLHLBC-UHFFFAOYSA-N 50504946 CHEMBL4450306 Carbonic anhydrase 4 Homo sapiens 29 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504946&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508314 440713531 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231606 COC(=O)CCCNC(=O)c1cc(c(Cl)cc1S(=O)(=O)Cc1ccccc1)S(N)(=O)=O InChI=1S/C19H21ClN2O7S2/c1-29-18(23)8-5-9-22-19(24)14-10-17(31(21,27)28)15(20)11-16(14)30(25,26)12-13-6-3-2-4-7-13/h2-4,6-7,10-11H,5,8-9,12H2,1H3,(H,22,24)(H2,21,27,28) NFUHGIUBDKRZQY-UHFFFAOYSA-N 50504931 CHEMBL4472400 Carbonic anhydrase 4 Homo sapiens 560 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504931&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507285 440713516 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231607 NS(=O)(=O)c1cc(C(=O)NCc2ccccc2)c(cc1Cl)S(=O)(=O)c1ccccc1 InChI=1S/C20H17ClN2O5S2/c21-17-12-18(29(25,26)15-9-5-2-6-10-15)16(11-19(17)30(22,27)28)20(24)23-13-14-7-3-1-4-8-14/h1-12H,13H2,(H,23,24)(H2,22,27,28) RFMRCPYSBXEKPD-UHFFFAOYSA-N 50504947 CHEMBL4517317 Carbonic anhydrase 4 Homo sapiens 32 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504947&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508363 440713532 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231608 CCCCNC(=O)c1cc(c(Br)cc1S(=O)(=O)c1ccccc1)S(N)(=O)=O InChI=1S/C17H19BrN2O5S2/c1-2-3-9-20-17(21)13-10-16(27(19,24)25)14(18)11-15(13)26(22,23)12-7-5-4-6-8-12/h4-8,10-11H,2-3,9H2,1H3,(H,20,21)(H2,19,24,25) FATAPRQFXGZRGG-UHFFFAOYSA-N 50504932 CHEMBL4576689 Carbonic anhydrase 4 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504932&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508716 440713517 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51231609 NS(=O)(=O)c1cc(C(=O)NCCCC(O)=O)c(SCc2ccccc2)cc1Cl InChI=1S/C18H19ClN2O5S2/c19-14-10-15(27-11-12-5-2-1-3-6-12)13(9-16(14)28(20,25)26)18(24)21-8-4-7-17(22)23/h1-3,5-6,9-10H,4,7-8,11H2,(H,21,24)(H,22,23)(H2,20,25,26) VSGAQEPRDWDRPO-UHFFFAOYSA-N 50504919 CHEMBL4445515 Carbonic anhydrase 4 Homo sapiens 61 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504919&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155517801 440713504 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230524 NC(=O)c1cc(c(Cl)cc1SCCc1ccccc1)S(N)(=O)=O InChI=1S/C15H15ClN2O3S2/c16-12-9-13(22-7-6-10-4-2-1-3-5-10)11(15(17)19)8-14(12)23(18,20)21/h1-5,8-9H,6-7H2,(H2,17,19)(H2,18,20,21) YEZJTTVQWKXURB-UHFFFAOYSA-N 50504911 CHEMBL4456851 Carbonic anhydrase 4 Homo sapiens 0.170000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504911&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155526221 440713496 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230536 CCCCNC(=O)c1cc(c(Cl)cc1Sc1ccccc1)S(N)(=O)=O InChI=1S/C17H19ClN2O3S2/c1-2-3-9-20-17(21)13-10-16(25(19,22)23)14(18)11-15(13)24-12-7-5-4-6-8-12/h4-8,10-11H,2-3,9H2,1H3,(H,20,21)(H2,19,22,23) LHVJYOYHQKRYSI-UHFFFAOYSA-N 50504900 CHEMBL4574321 Carbonic anhydrase 4 Homo sapiens 0.005000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504900&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508306 440713485 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230537 NS(=O)(=O)c1cc(C(=O)NC2CCCCC2)c(Sc2ccccc2)cc1Cl InChI=1S/C19H21ClN2O3S2/c20-16-12-17(26-14-9-5-2-6-10-14)15(11-18(16)27(21,24)25)19(23)22-13-7-3-1-4-8-13/h2,5-6,9-13H,1,3-4,7-8H2,(H,22,23)(H2,21,24,25) IGLDOHLJJIKASI-UHFFFAOYSA-N 50504948 CHEMBL4573894 Carbonic anhydrase 4 Homo sapiens 0.150000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504948&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126509024 440713533 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230538 NS(=O)(=O)c1cc(C(=O)NCCO)c(SC2CCCCC2)cc1Br InChI=1S/C15H21BrN2O4S2/c16-12-9-13(23-10-4-2-1-3-5-10)11(15(20)18-6-7-19)8-14(12)24(17,21)22/h8-10,19H,1-7H2,(H,18,20)(H2,17,21,22) MOQPYUBNCWCUAP-UHFFFAOYSA-N 50504933 CHEMBL4539233 Carbonic anhydrase 4 Homo sapiens 0.170000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504933&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508088 440713518 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230539 COCCNC(=O)c1cc(c(Cl)cc1S(=O)(=O)c1ccccc1)S(N)(=O)=O InChI=1S/C16H17ClN2O6S2/c1-25-8-7-19-16(20)12-9-15(27(18,23)24)13(17)10-14(12)26(21,22)11-5-3-2-4-6-11/h2-6,9-10H,7-8H2,1H3,(H,19,20)(H2,18,23,24) PCIBFBDEVBBIFN-UHFFFAOYSA-N 50504928 CHEMBL4592616 Carbonic anhydrase 4 Homo sapiens 0.150000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504928&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507863 440713513 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230545 CC(=O)OCCCNC(=O)c1cc(c(Cl)cc1Cl)S(N)(=O)=O InChI=1S/C12H14Cl2N2O5S/c1-7(17)21-4-2-3-16-12(18)8-5-11(22(15,19)20)10(14)6-9(8)13/h5-6H,2-4H2,1H3,(H,16,18)(H2,15,19,20) ZYZYGWWRCWBUMZ-UHFFFAOYSA-N 50449810 CHEMBL4162133 Carbonic anhydrase 4 Homo sapiens 0.270000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449810&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126507183 433919373 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230567 NS(=O)(=O)c1cc(C(=O)NCc2ccccc2)c(cc1Cl)S(=O)(=O)c1ccccc1 InChI=1S/C20H17ClN2O5S2/c21-17-12-18(29(25,26)15-9-5-2-6-10-15)16(11-19(17)30(22,27)28)20(24)23-13-14-7-3-1-4-8-14/h1-12H,13H2,(H,23,24)(H2,22,27,28) RFMRCPYSBXEKPD-UHFFFAOYSA-N 50504947 CHEMBL4517317 Carbonic anhydrase 4 Homo sapiens 0.470000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504947&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508363 440713532 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51230573 NS(=O)(=O)c1cc(C(=O)NCCCC(O)=O)c(Cl)cc1Cl InChI=1S/C11H12Cl2N2O5S/c12-7-5-8(13)9(21(14,19)20)4-6(7)11(18)15-3-1-2-10(16)17/h4-5H,1-3H2,(H,15,18)(H,16,17)(H2,14,19,20) AZHHAHHRNOQVSO-UHFFFAOYSA-N 50449821 CHEMBL4168586 Carbonic anhydrase 4 Homo sapiens 0.950000 ChEMBL 10.1016/j.ejmech.2019.111825 10.7270/Q2VX0KS1 31740053 Zakšauskas, A; Čapkauskaitė, E; Jezepčikas, L; Linkuvienė, V; Paketurytė, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gražulis, S; Tars, K; Matulis, D Vilnius University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50449821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50449821&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 126508712 433919384 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262752 COC(=O)[C@@H]1CC(=O)N([C@H]1c1ccc(cc1)S(N)(=O)=O)c1ccc(Cl)cc1 InChI=1S/C18H17ClN2O5S/c1-26-18(23)15-10-16(22)21(13-6-4-12(19)5-7-13)17(15)11-2-8-14(9-3-11)27(20,24)25/h2-9,15,17H,10H2,1H3,(H2,20,24,25)/t15-,17+/m1/s1 MOWOSCLHTAMNBU-WBVHZDCISA-N 50515840 CHEMBL4461506 Carbonic anhydrase 4 Homo sapiens 8695 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515840&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155528496 440724422 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262759 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(=O)NCCO)c1ccc(Cl)cc1 InChI=1S/C19H20ClN3O5S/c20-13-3-1-12(2-4-13)18-16(19(26)22-9-10-24)11-17(25)23(18)14-5-7-15(8-6-14)29(21,27)28/h1-8,16,18,24H,9-11H2,(H,22,26)(H2,21,27,28)/t16-,18+/m0/s1 ZTNPVYBROJICQU-FUHWJXTLSA-N 50515848 CHEMBL4476050 Carbonic anhydrase 4 Homo sapiens 0.900000 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515848&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155538083 440724430 C04080 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262760 COC(=O)[C@@H]1CC(=O)N([C@H]1c1ccc(OC)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H20N2O6S/c1-26-14-7-3-12(4-8-14)18-16(19(23)27-2)11-17(22)21(18)13-5-9-15(10-6-13)28(20,24)25/h3-10,16,18H,11H2,1-2H3,(H2,20,24,25)/t16-,18+/m1/s1 XHGVQCGRXICSSQ-AEFFLSMTSA-N 50515849 CHEMBL4475477 Carbonic anhydrase 4 Homo sapiens 444 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515849&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155538073 440724431 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262761 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(=O)N1CCCC1)c1ccc(Cl)cc1 InChI=1S/C21H22ClN3O4S/c22-15-5-3-14(4-6-15)20-18(21(27)24-11-1-2-12-24)13-19(26)25(20)16-7-9-17(10-8-16)30(23,28)29/h3-10,18,20H,1-2,11-13H2,(H2,23,28,29)/t18-,20+/m0/s1 CZNKNNRUTDEQQO-AZUAARDMSA-N 50515850 CHEMBL4543874 Carbonic anhydrase 4 Homo sapiens 85 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515850&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155552594 440724432 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262762 COC(=O)CNC(=O)[C@H]1CC(=O)N([C@@H]1c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C20H20ClN3O6S/c1-30-18(26)11-23-20(27)16-10-17(25)24(19(16)12-2-4-13(21)5-3-12)14-6-8-15(9-7-14)31(22,28)29/h2-9,16,19H,10-11H2,1H3,(H,23,27)(H2,22,28,29)/t16-,19+/m0/s1 RLXUVFFUDNUUNP-QFBILLFUSA-N 50515851 CHEMBL4453623 Carbonic anhydrase 4 Homo sapiens 2.4 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515851&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155522679 440724433 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255421 NS(=O)(=O)c1ccc(NC(=O)CN2C(=O)NC3(CCCCCC3)C2=O)cc1 InChI=1S/C17H22N4O5S/c18-27(25,26)13-7-5-12(6-8-13)19-14(22)11-21-15(23)17(20-16(21)24)9-3-1-2-4-10-17/h5-8H,1-4,9-11H2,(H,19,22)(H,20,24)(H2,18,25,26) WALKBCDYHSEIBJ-UHFFFAOYSA-N 50513282 CHEMBL4473062 Carbonic anhydrase 4 Homo sapiens 97 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513282&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 8S 6OE0 138753317 440721864 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255422 NS(=O)(=O)c1ccc(C[Se]c2ccc(NC(=O)CN3C(=O)NC4(CCCCC4)C3=O)cc2)cc1 InChI=1S/C23H26N4O5SSe/c24-33(31,32)18-8-4-16(5-9-18)15-34-19-10-6-17(7-11-19)25-20(28)14-27-21(29)23(26-22(27)30)12-2-1-3-13-23/h4-11H,1-3,12-15H2,(H,25,28)(H,26,30)(H2,24,31,32) FHBDNRMYKOVBPS-UHFFFAOYSA-N 50513286 CHEMBL4470319 Carbonic anhydrase 4 Homo sapiens 9724 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513286&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155534179 440721868 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262809 COC(=O)[C@@H]1CC(=O)N([C@H]1c1ccc(cc1)S(N)(=O)=O)c1ccc(Br)cc1 InChI=1S/C18H17BrN2O5S/c1-26-18(23)15-10-16(22)21(13-6-4-12(19)5-7-13)17(15)11-2-8-14(9-3-11)27(20,24)25/h2-9,15,17H,10H2,1H3,(H2,20,24,25)/t15-,17+/m1/s1 LUQBZEDMKFKMGI-WBVHZDCISA-N 50515870 CHEMBL4464496 Carbonic anhydrase 4 Homo sapiens 974 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515870&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155530440 440724452 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262810 COC(=O)[C@@H]1CC(=O)N(C(C)C)[C@H]1c1ccc(cc1)S(N)(=O)=O InChI=1S/C15H20N2O5S/c1-9(2)17-13(18)8-12(15(19)22-3)14(17)10-4-6-11(7-5-10)23(16,20)21/h4-7,9,12,14H,8H2,1-3H3,(H2,16,20,21)/t12-,14+/m1/s1 DBXHVUXNNWVRKI-OCCSQVGLSA-N 50515847 CHEMBL4525693 Carbonic anhydrase 4 Homo sapiens 543 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515847&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155543228 440724429 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262811 CCN1[C@H]([C@@H](CC1=O)C(=O)OC)c1ccc(cc1)S(N)(=O)=O InChI=1S/C14H18N2O5S/c1-3-16-12(17)8-11(14(18)21-2)13(16)9-4-6-10(7-5-9)22(15,19)20/h4-7,11,13H,3,8H2,1-2H3,(H2,15,19,20)/t11-,13+/m1/s1 LTVLMZQCEKUIQB-YPMHNXCESA-N 50515872 CHEMBL4444078 Carbonic anhydrase 4 Homo sapiens 433 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515872&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155517026 440724454 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262812 COC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)CN1S(C)(=O)=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H23N3O7S2/c1-10(2)19-13(20)9-18(27(4,22)23)15(16(21)26-3)14(19)11-5-7-12(8-6-11)28(17,24)25/h5-8,10,14-15H,9H2,1-4H3,(H2,17,24,25)/t14-,15+/m0/s1 BIXRWCJUESIJPO-LSDHHAIUSA-N 50515857 CHEMBL4540833 Carbonic anhydrase 4 Homo sapiens 521 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515857&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155550626 440724439 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262813 COC(=O)[C@@H]1OCC(=O)N(C(C)C)[C@H]1c1ccc(cc1)S(N)(=O)=O InChI=1S/C15H20N2O6S/c1-9(2)17-12(18)8-23-14(15(19)22-3)13(17)10-4-6-11(7-5-10)24(16,20)21/h4-7,9,13-14H,8H2,1-3H3,(H2,16,20,21)/t13-,14+/m0/s1 OWKYPJZIRNCORN-UONOGXRCSA-N 50515858 CHEMBL4463775 Carbonic anhydrase 4 Homo sapiens 9720 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515858&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155529984 440724440 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262814 COC(=O)[C@@H]1CC(=O)N([C@H]1c1ccccc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C18H18N2O5S/c1-25-18(22)15-11-16(21)20(17(15)12-5-3-2-4-6-12)13-7-9-14(10-8-13)26(19,23)24/h2-10,15,17H,11H2,1H3,(H2,19,23,24)/t15-,17+/m1/s1 GZJKGWRWCBDNPT-WBVHZDCISA-N 50515859 CHEMBL4482951 Carbonic anhydrase 4 Homo sapiens 958 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515859&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155539868 440724441 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262815 COC(=O)[C@@H]1CC(=O)N([C@H]1c1ccc(F)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C18H17FN2O5S/c1-26-18(23)15-10-16(22)21(17(15)11-2-4-12(19)5-3-11)13-6-8-14(9-7-13)27(20,24)25/h2-9,15,17H,10H2,1H3,(H2,20,24,25)/t15-,17+/m1/s1 GOMKLKMHMLKMDT-WBVHZDCISA-N 50515860 CHEMBL4455825 Carbonic anhydrase 4 Homo sapiens 81 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515860&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155524712 440724442 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262816 COC(=O)[C@H]1[C@@H](N(C(=O)CN1S(C)(=O)=O)c1ccc(cc1)S(N)(=O)=O)c1ccc(C)cc1 InChI=1S/C20H23N3O7S2/c1-13-4-6-14(7-5-13)18-19(20(25)30-2)22(31(3,26)27)12-17(24)23(18)15-8-10-16(11-9-15)32(21,28)29/h4-11,18-19H,12H2,1-3H3,(H2,21,28,29)/t18-,19+/m0/s1 RUACOAMJVHCUGA-RBUKOAKNSA-N 50515844 CHEMBL4474384 Carbonic anhydrase 4 Homo sapiens 713 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515844&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155536876 440724426 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262817 COC(=O)[C@@H]1OCC(=O)N([C@H]1c1ccc(C)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H20N2O6S/c1-12-3-5-13(6-4-12)17-18(19(23)26-2)27-11-16(22)21(17)14-7-9-15(10-8-14)28(20,24)25/h3-10,17-18H,11H2,1-2H3,(H2,20,24,25)/t17-,18+/m0/s1 OWICWGWYCBDTEH-ZWKOTPCHSA-N 50515861 CHEMBL4470503 Carbonic anhydrase 4 Homo sapiens 608 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515861&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155534753 440724443 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262818 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(O)=O)c1ccc(Cl)cc1 InChI=1S/C17H15ClN2O5S/c18-11-3-1-10(2-4-11)16-14(17(22)23)9-15(21)20(16)12-5-7-13(8-6-12)26(19,24)25/h1-8,14,16H,9H2,(H,22,23)(H2,19,24,25)/t14-,16+/m0/s1 AXVLQOCBWGDELE-GOEBONIOSA-N 50515862 CHEMBL4474463 Carbonic anhydrase 4 Homo sapiens 25 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515862&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155537042 440724444 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262819 NC(=O)[C@H]1CC(=O)N([C@@H]1c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C17H16ClN3O4S/c18-11-3-1-10(2-4-11)16-14(17(19)23)9-15(22)21(16)12-5-7-13(8-6-12)26(20,24)25/h1-8,14,16H,9H2,(H2,19,23)(H2,20,24,25)/t14-,16+/m0/s1 LJVIXSBCXLHRRM-GOEBONIOSA-N 50515863 CHEMBL4443290 Carbonic anhydrase 4 Homo sapiens 69 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515863&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155516304 440724445 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262820 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(=O)N1CCSCC1)c1ccc(Cl)cc1 InChI=1S/C21H22ClN3O4S2/c22-15-3-1-14(2-4-15)20-18(21(27)24-9-11-30-12-10-24)13-19(26)25(20)16-5-7-17(8-6-16)31(23,28)29/h1-8,18,20H,9-13H2,(H2,23,28,29)/t18-,20+/m0/s1 OXSANGDEICDQFL-AZUAARDMSA-N 50515842 CHEMBL4440932 Carbonic anhydrase 4 Homo sapiens 22 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515842&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155514660 440724424 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262821 CN1CCN(CC1)C(=O)[C@H]1CC(=O)N([C@@H]1c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C22H25ClN4O4S/c1-25-10-12-26(13-11-25)22(29)19-14-20(28)27(21(19)15-2-4-16(23)5-3-15)17-6-8-18(9-7-17)32(24,30)31/h2-9,19,21H,10-14H2,1H3,(H2,24,30,31)/t19-,21+/m0/s1 CIXRBVPFMWBGEY-PZJWPPBQSA-N 50515864 CHEMBL4516972 Carbonic anhydrase 4 Homo sapiens 4.7 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515864&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155540422 440724446 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262822 CN(C)CCCNC(=O)[C@H]1CC(=O)N([C@@H]1c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C22H27ClN4O4S/c1-26(2)13-3-12-25-22(29)19-14-20(28)27(21(19)15-4-6-16(23)7-5-15)17-8-10-18(11-9-17)32(24,30)31/h4-11,19,21H,3,12-14H2,1-2H3,(H,25,29)(H2,24,30,31)/t19-,21+/m0/s1 FKMBSEVMCQVMPX-PZJWPPBQSA-N 50515873 CHEMBL4586855 Carbonic anhydrase 4 Homo sapiens 0.520000 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515873&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155566378 440724455 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262823 CC(=O)OCCNC(=O)[C@H]1CC(=O)N([C@@H]1c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C21H22ClN3O6S/c1-13(26)31-11-10-24-21(28)18-12-19(27)25(20(18)14-2-4-15(22)5-3-14)16-6-8-17(9-7-16)32(23,29)30/h2-9,18,20H,10-12H2,1H3,(H,24,28)(H2,23,29,30)/t18-,20+/m0/s1 OPUSYVWGYWIQQV-AZUAARDMSA-N 50515874 CHEMBL4550339 Carbonic anhydrase 4 Homo sapiens 0.590000 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515874&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155555084 440724456 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262824 CC(=O)OCCCNC(=O)[C@H]1CC(=O)N([C@@H]1c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C22H24ClN3O6S/c1-14(27)32-12-2-11-25-22(29)19-13-20(28)26(21(19)15-3-5-16(23)6-4-15)17-7-9-18(10-8-17)33(24,30)31/h3-10,19,21H,2,11-13H2,1H3,(H,25,29)(H2,24,30,31)/t19-,21+/m0/s1 PLXFEBWBFQDARH-PZJWPPBQSA-N 50515871 CHEMBL4457120 Carbonic anhydrase 4 Homo sapiens 1.8 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515871&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155526086 440724453 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262825 COC(=O)CCCNC(=O)[C@H]1CC(=O)N([C@@H]1c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C22H24ClN3O6S/c1-32-20(28)3-2-12-25-22(29)18-13-19(27)26(21(18)14-4-6-15(23)7-5-14)16-8-10-17(11-9-16)33(24,30)31/h4-11,18,21H,2-3,12-13H2,1H3,(H,25,29)(H2,24,30,31)/t18-,21+/m0/s1 GVTXSDKXXNSRQQ-GHTZIAJQSA-N 50515852 CHEMBL4461778 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515852&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155528761 440724434 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262826 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(=O)NCCN1CCOCC1)c1ccc(Cl)cc1 InChI=1S/C23H27ClN4O5S/c24-17-3-1-16(2-4-17)22-20(23(30)26-9-10-27-11-13-33-14-12-27)15-21(29)28(22)18-5-7-19(8-6-18)34(25,31)32/h1-8,20,22H,9-15H2,(H,26,30)(H2,25,31,32)/t20-,22+/m0/s1 UKLYQVJGVRTICD-RBBKRZOGSA-N 50515843 CHEMBL4446872 Carbonic anhydrase 4 Homo sapiens 0.610000 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515843&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155518447 440724425 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262827 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(=O)NCCCN1CCCC1)c1ccc(Cl)cc1 InChI=1S/C24H29ClN4O4S/c25-18-6-4-17(5-7-18)23-21(24(31)27-12-3-15-28-13-1-2-14-28)16-22(30)29(23)19-8-10-20(11-9-19)34(26,32)33/h4-11,21,23H,1-3,12-16H2,(H,27,31)(H2,26,32,33)/t21-,23+/m0/s1 KZFHHLGLHNFERJ-JTHBVZDNSA-N 50515846 CHEMBL4586708 Carbonic anhydrase 4 Homo sapiens 0.890000 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515846&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155566755 440724428 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262828 CN1CCN(CCCNC(=O)[C@H]2CC(=O)N([C@@H]2c2ccc(Cl)cc2)c2ccc(cc2)S(N)(=O)=O)CC1 InChI=1S/C25H32ClN5O4S/c1-29-13-15-30(16-14-29)12-2-11-28-25(33)22-17-23(32)31(24(22)18-3-5-19(26)6-4-18)20-7-9-21(10-8-20)36(27,34)35/h3-10,22,24H,2,11-17H2,1H3,(H,28,33)(H2,27,34,35)/t22-,24+/m0/s1 NGZOQZVYWJILDN-LADGPHEKSA-N 50515868 CHEMBL4521611 Carbonic anhydrase 4 Homo sapiens 0.390000 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515868&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155542691 440724450 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262829 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(=O)NCCCO)c1ccc(Cl)cc1 InChI=1S/C20H22ClN3O5S/c21-14-4-2-13(3-5-14)19-17(20(27)23-10-1-11-25)12-18(26)24(19)15-6-8-16(9-7-15)30(22,28)29/h2-9,17,19,25H,1,10-12H2,(H,23,27)(H2,22,28,29)/t17-,19+/m0/s1 HEHPEFQHZKOOLK-PKOBYXMFSA-N 50515869 CHEMBL4577408 Carbonic anhydrase 4 Homo sapiens 0.220000 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515869&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155564664 440724451 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262830 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(=O)NCCC(O)=O)c1ccc(Cl)cc1 InChI=1S/C20H20ClN3O6S/c21-13-3-1-12(2-4-13)19-16(20(28)23-10-9-18(26)27)11-17(25)24(19)14-5-7-15(8-6-14)31(22,29)30/h1-8,16,19H,9-11H2,(H,23,28)(H,26,27)(H2,22,29,30)/t16-,19+/m0/s1 ZXWOFYXXMIUWJC-QFBILLFUSA-N 50515853 CHEMBL4573177 Carbonic anhydrase 4 Homo sapiens 0.310000 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515853&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155563623 440724435 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262831 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(=O)NCCCC(O)=O)c1ccc(Cl)cc1 InChI=1S/C21H22ClN3O6S/c22-14-5-3-13(4-6-14)20-17(21(29)24-11-1-2-19(27)28)12-18(26)25(20)15-7-9-16(10-8-15)32(23,30)31/h3-10,17,20H,1-2,11-12H2,(H,24,29)(H,27,28)(H2,23,30,31)/t17-,20+/m0/s1 QFADCDGPZHWTEJ-FXAWDEMLSA-N 50515875 CHEMBL4469501 Carbonic anhydrase 4 Homo sapiens 1.8 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515875&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155533528 440724457 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262863 COC(=O)[C@@H]1CC(=O)N([C@H]1c1ccc(cc1)S(N)(=O)=O)c1ccc(OC)cc1 InChI=1S/C19H20N2O6S/c1-26-14-7-5-13(6-8-14)21-17(22)11-16(19(23)27-2)18(21)12-3-9-15(10-4-12)28(20,24)25/h3-10,16,18H,11H2,1-2H3,(H2,20,24,25)/t16-,18+/m1/s1 JIXJQYLYFCMQJV-AEFFLSMTSA-N 50515855 CHEMBL4538471 Carbonic anhydrase 4 Homo sapiens 886 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515855&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155549266 440724437 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262872 COC(=O)[C@@H]1CC(=O)N([C@H]1c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C18H17ClN2O5S/c1-26-18(23)15-10-16(22)21(17(15)11-2-4-12(19)5-3-11)13-6-8-14(9-7-13)27(20,24)25/h2-9,15,17H,10H2,1H3,(H2,20,24,25)/t15-,17+/m1/s1 XLJGLKFOOZEQKH-WBVHZDCISA-N 50515841 CHEMBL4577187 Carbonic anhydrase 4 Homo sapiens 9.6 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515841&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155553759 440724423 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262873 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(=O)NCCCn1ccnc1)c1ccc(Cl)cc1 InChI=1S/C23H24ClN5O4S/c24-17-4-2-16(3-5-17)22-20(23(31)27-10-1-12-28-13-11-26-15-28)14-21(30)29(22)18-6-8-19(9-7-18)34(25,32)33/h2-9,11,13,15,20,22H,1,10,12,14H2,(H,27,31)(H2,25,32,33)/t20-,22+/m0/s1 ICBZOYHXUKPRCT-RBBKRZOGSA-N 50515877 CHEMBL4462700 Carbonic anhydrase 4 Homo sapiens 0.660000 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515877&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155529373 440724459 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255486 NS(=O)(=O)c1ccc(NC(=O)CN2C(=O)NC3(CCCC3)C2=O)cc1 InChI=1S/C15H18N4O5S/c16-25(23,24)11-5-3-10(4-6-11)17-12(20)9-19-13(21)15(18-14(19)22)7-1-2-8-15/h3-6H,1-2,7-9H2,(H,17,20)(H,18,22)(H2,16,23,24) PWGCLXASZRXSOJ-UHFFFAOYSA-N 50513289 CHEMBL4435918 Carbonic anhydrase 4 Homo sapiens 627 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513289&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 8J 6ODZ 138393379 440721871 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255487 NS(=O)(=O)c1ccc(NC(=O)CN2C(=O)NC3(CCCCC3)C2=O)cc1 InChI=1S/C16H20N4O5S/c17-26(24,25)12-6-4-11(5-7-12)18-13(21)10-20-14(22)16(19-15(20)23)8-2-1-3-9-16/h4-7H,1-3,8-10H2,(H,18,21)(H,19,23)(H2,17,24,25) KZSVRJBEJFDDMB-UHFFFAOYSA-N 50513292 CHEMBL4541654 Carbonic anhydrase 4 Homo sapiens 449 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513292&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 8V 6OE1 2388085 440721874 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255488 NS(=O)(=O)c1ccc(CNC(=O)CN2C(=O)NC3(CCCC3)C2=O)cc1 InChI=1S/C16H20N4O5S/c17-26(24,25)12-5-3-11(4-6-12)9-18-13(21)10-20-14(22)16(19-15(20)23)7-1-2-8-16/h3-6H,1-2,7-10H2,(H,18,21)(H,19,23)(H2,17,24,25) GCYWRQQBDWFWAK-UHFFFAOYSA-N 50513290 CHEMBL4444589 Carbonic anhydrase 4 Homo sapiens 3555 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513290&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155517430 440721872 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255489 NS(=O)(=O)c1ccc(CNC(=O)CN2C(=O)NC3(CCCCC3)C2=O)cc1 InChI=1S/C17H22N4O5S/c18-27(25,26)13-6-4-12(5-7-13)10-19-14(22)11-21-15(23)17(20-16(21)24)8-2-1-3-9-17/h4-7H,1-3,8-11H2,(H,19,22)(H,20,24)(H2,18,25,26) WVTVLUWYWYNJRU-UHFFFAOYSA-N 50513288 CHEMBL4443862 Carbonic anhydrase 4 Homo sapiens 2356 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513288&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155516517 440721870 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255490 NS(=O)(=O)c1ccc(CNC(=O)CN2C(=O)NC3(CCCCCC3)C2=O)cc1 InChI=1S/C18H24N4O5S/c19-28(26,27)14-7-5-13(6-8-14)11-20-15(23)12-22-16(24)18(21-17(22)25)9-3-1-2-4-10-18/h5-8H,1-4,9-12H2,(H,20,23)(H,21,25)(H2,19,26,27) QUAFYIJGNASVBL-UHFFFAOYSA-N 50513294 CHEMBL4519699 Carbonic anhydrase 4 Homo sapiens 1613 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513294&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155541805 440721876 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255491 CC1CCCC2(C1)NC(=O)N(CC(=O)NCc1ccc(cc1)S(N)(=O)=O)C2=O InChI=1S/C18H24N4O5S/c1-12-3-2-8-18(9-12)16(24)22(17(25)21-18)11-15(23)20-10-13-4-6-14(7-5-13)28(19,26)27/h4-7,12H,2-3,8-11H2,1H3,(H,20,23)(H,21,25)(H2,19,26,27) RHOCPQDYVNIVHE-UHFFFAOYSA-N 50513295 CHEMBL4592146 Carbonic anhydrase 4 Homo sapiens 6390 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513295&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155568899 440721877 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255492 CC1CCCC2(C1)NC(=O)N(CC(=O)NCCc1ccc(cc1)S(N)(=O)=O)C2=O InChI=1S/C19H26N4O5S/c1-13-3-2-9-19(11-13)17(25)23(18(26)22-19)12-16(24)21-10-8-14-4-6-15(7-5-14)29(20,27)28/h4-7,13H,2-3,8-12H2,1H3,(H,21,24)(H,22,26)(H2,20,27,28) BSXMHLSQAUUGRB-UHFFFAOYSA-N 50513283 CHEMBL4534829 Carbonic anhydrase 4 Homo sapiens 7186 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513283&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155549031 440721865 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262891 COC(=O)[C@H]1[C@@H](N(C(=O)CN1S(C)(=O)=O)c1ccc(Cl)c(Cl)c1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H19Cl2N3O7S2/c1-31-19(26)18-17(11-3-6-13(7-4-11)33(22,29)30)24(12-5-8-14(20)15(21)9-12)16(25)10-23(18)32(2,27)28/h3-9,17-18H,10H2,1-2H3,(H2,22,29,30)/t17-,18+/m0/s1 KAGBJSCQLCDJLZ-ZWKOTPCHSA-N 50515856 CHEMBL4448003 Carbonic anhydrase 4 Homo sapiens 434 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515856&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155519432 440724438 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262892 COC(=O)[C@@H]1CC(=O)N([C@H]1c1ccc(C)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C19H20N2O5S/c1-12-3-5-13(6-4-12)18-16(19(23)26-2)11-17(22)21(18)14-7-9-15(10-8-14)27(20,24)25/h3-10,16,18H,11H2,1-2H3,(H2,20,24,25)/t16-,18+/m1/s1 RPZHLWQWQFZNSB-AEFFLSMTSA-N 50515879 CHEMBL4565471 Carbonic anhydrase 4 Homo sapiens 72 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515879&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155544664 440724461 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262893 COC(=O)[C@H]1[C@@H](N(C(=O)CN1S(C)(=O)=O)c1ccc(cc1)S(N)(=O)=O)c1ccc(Cl)c(Cl)c1 InChI=1S/C19H19Cl2N3O7S2/c1-31-19(26)18-17(11-3-8-14(20)15(21)9-11)24(16(25)10-23(18)32(2,27)28)12-4-6-13(7-5-12)33(22,29)30/h3-9,17-18H,10H2,1-2H3,(H2,22,29,30)/t17-,18+/m0/s1 UWGUQUKPALCVBX-ZWKOTPCHSA-N 50515876 CHEMBL4519299 Carbonic anhydrase 4 Homo sapiens 778 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515876&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155541811 440724458 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262894 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(=O)N1CCOCC1)c1ccc(Cl)cc1 InChI=1S/C21H22ClN3O5S/c22-15-3-1-14(2-4-15)20-18(21(27)24-9-11-30-12-10-24)13-19(26)25(20)16-5-7-17(8-6-16)31(23,28)29/h1-8,18,20H,9-13H2,(H2,23,28,29)/t18-,20+/m0/s1 AYEUOBANRGNZCV-AZUAARDMSA-N 50515854 CHEMBL4472013 Carbonic anhydrase 4 Homo sapiens 31 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515854&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155535780 440724436 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262895 CN(C)CCNC(=O)[C@H]1CC(=O)N([C@@H]1c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C21H25ClN4O4S/c1-25(2)12-11-24-21(28)18-13-19(27)26(20(18)14-3-5-15(22)6-4-14)16-7-9-17(10-8-16)31(23,29)30/h3-10,18,20H,11-13H2,1-2H3,(H,24,28)(H2,23,29,30)/t18-,20+/m0/s1 UVKIOPOVVORPAI-AZUAARDMSA-N 50515865 CHEMBL4440330 Carbonic anhydrase 4 Homo sapiens 1.2 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515865&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155514471 440724447 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262896 COC(=O)CCNC(=O)[C@H]1CC(=O)N([C@@H]1c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C21H22ClN3O6S/c1-31-19(27)10-11-24-21(28)17-12-18(26)25(20(17)13-2-4-14(22)5-3-13)15-6-8-16(9-7-15)32(23,29)30/h2-9,17,20H,10-12H2,1H3,(H,24,28)(H2,23,29,30)/t17-,20+/m0/s1 RJJMKCCURXTXFK-FXAWDEMLSA-N 50515866 CHEMBL4593200 Carbonic anhydrase 4 Homo sapiens 1.000000 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515866&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155569151 440724448 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262897 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(=O)NCCCN1CCOCC1)c1ccc(Cl)cc1 InChI=1S/C24H29ClN4O5S/c25-18-4-2-17(3-5-18)23-21(24(31)27-10-1-11-28-12-14-34-15-13-28)16-22(30)29(23)19-6-8-20(9-7-19)35(26,32)33/h2-9,21,23H,1,10-16H2,(H,27,31)(H2,26,32,33)/t21-,23+/m0/s1 YHMMMMGEFDYAPV-JTHBVZDNSA-N 50515867 CHEMBL4475435 Carbonic anhydrase 4 Homo sapiens 1.5 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515867&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155538069 440724449 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262898 NS(=O)(=O)c1ccc(cc1)N1[C@@H]([C@H](CC1=O)C(=O)NCC(O)=O)c1ccc(Cl)cc1 InChI=1S/C19H18ClN3O6S/c20-12-3-1-11(2-4-12)18-15(19(27)22-10-17(25)26)9-16(24)23(18)13-5-7-14(8-6-13)30(21,28)29/h1-8,15,18H,9-10H2,(H,22,27)(H,25,26)(H2,21,28,29)/t15-,18+/m0/s1 RYZBYQZMIOEJRN-MAUKXSAKSA-N 50515878 CHEMBL4569748 Carbonic anhydrase 4 Homo sapiens 0.650000 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515878&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155552113 440724460 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262899 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51262910 COc1ccc(CNC(=O)[C@H]2CC(=O)N([C@@H]2c2ccc(Cl)cc2)c2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C25H24ClN3O5S/c1-34-20-10-2-16(3-11-20)15-28-25(31)22-14-23(30)29(24(22)17-4-6-18(26)7-5-17)19-8-12-21(13-9-19)35(27,32)33/h2-13,22,24H,14-15H2,1H3,(H,28,31)(H2,27,32,33)/t22-,24+/m0/s1 ROBGBDSQNMSQOC-LADGPHEKSA-N 50515845 CHEMBL4450666 Carbonic anhydrase 4 Homo sapiens 2.1 ChEMBL 10.1016/j.ejmech.2019.111642 10.7270/Q2C250SX 31476557 Kalinin, S; Nocentini, A; Kovalenko, A; Sharoyko, V; Bonardi, A; Angeli, A; Gratteri, P; Tennikova, TB; Supuran, CT; Krasavin, M Saint Petersburg State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515845&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155521700 440724427 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255528 NS(=O)(=O)c1ccc(CCNC(=O)CN2C(=O)NC3(CCCC3)C2=O)cc1 InChI=1S/C17H22N4O5S/c18-27(25,26)13-5-3-12(4-6-13)7-10-19-14(22)11-21-15(23)17(20-16(21)24)8-1-2-9-17/h3-6H,1-2,7-11H2,(H,19,22)(H,20,24)(H2,18,25,26) RFPXNPAWDLLRQG-UHFFFAOYSA-N 50513284 CHEMBL4473622 Carbonic anhydrase 4 Homo sapiens 9657 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513284&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 18268734 440721866 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255529 CC1CCCC2(C1)NC(=O)N(CC(=O)Nc1ccc([Se]Cc3ccc(cc3)S(N)(=O)=O)cc1)C2=O InChI=1S/C24H28N4O5SSe/c1-16-3-2-12-24(13-16)22(30)28(23(31)27-24)14-21(29)26-18-6-10-20(11-7-18)35-15-17-4-8-19(9-5-17)34(25,32)33/h4-11,16H,2-3,12-15H2,1H3,(H,26,29)(H,27,31)(H2,25,32,33) RURXXKAQYWCADT-UHFFFAOYSA-N 50513291 CHEMBL4448793 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513291&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155520274 440721873 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255557 NS(=O)(=O)c1ccc(CCNC(=O)CN2C(=O)NC3(CCCCC3)C2=O)cc1 InChI=1S/C18H24N4O5S/c19-28(26,27)14-6-4-13(5-7-14)8-11-20-15(23)12-22-16(24)18(21-17(22)25)9-2-1-3-10-18/h4-7H,1-3,8-12H2,(H,20,23)(H,21,25)(H2,19,26,27) NIHPKECMCOYBPP-UHFFFAOYSA-N 50513296 CHEMBL4441613 Carbonic anhydrase 4 Homo sapiens 8012 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513296&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 25392418 440721878 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255573 CC1CCCC2(C1)NC(=O)N(CC(=O)Nc1ccc(cc1)S(N)(=O)=O)C2=O InChI=1S/C17H22N4O5S/c1-11-3-2-8-17(9-11)15(23)21(16(24)20-17)10-14(22)19-12-4-6-13(7-5-12)27(18,25)26/h4-7,11H,2-3,8-10H2,1H3,(H,19,22)(H,20,24)(H2,18,25,26) QUTUODGLIAAMJE-UHFFFAOYSA-N 50513293 CHEMBL4471521 Carbonic anhydrase 4 Homo sapiens 97 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513293&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155535355 440721875 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255574 NS(=O)(=O)c1ccc(CCNC(=O)CN2C(=O)NC3(CCCCCC3)C2=O)cc1 InChI=1S/C19H26N4O5S/c20-29(27,28)15-7-5-14(6-8-15)9-12-21-16(24)13-23-17(25)19(22-18(23)26)10-3-1-2-4-11-19/h5-8H,1-4,9-13H2,(H,21,24)(H,22,26)(H2,20,27,28) LEXSGEGFGNKJNL-UHFFFAOYSA-N 50513285 CHEMBL4553772 Carbonic anhydrase 4 Homo sapiens 6491 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513285&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155555878 440721867 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255575 NS(=O)(=O)c1ccc(C[Se]c2ccc(NC(=O)CN3C(=O)NC4(CCCCCC4)C3=O)cc2)cc1 InChI=1S/C24H28N4O5SSe/c25-34(32,33)19-9-5-17(6-10-19)16-35-20-11-7-18(8-12-20)26-21(29)15-28-22(30)24(27-23(28)31)13-3-1-2-4-14-24/h5-12H,1-4,13-16H2,(H,26,29)(H,27,31)(H2,25,32,33) SVOIKZFEFRTKGE-UHFFFAOYSA-N 50513287 CHEMBL4464229 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513287&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155530506 440721869 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51255589 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2019.05.058 10.7270/Q2T156ZB 31136893 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226773 Cc1cc(N2CC(CC2=O)C(=O)NN)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C13H17ClN4O4S/c1-6-3-9(11(14)7(2)12(6)23(16,21)22)18-5-8(4-10(18)19)13(20)17-15/h3,8H,4-5,15H2,1-2H3,(H,17,20)(H2,16,21,22) ZZBVZOGPOHYKDO-UHFFFAOYSA-N 50503790 CHEMBL4458989 Carbonic anhydrase 4 Homo sapiens 0.180000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503790&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155527199 440712375 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226788 COc1ccc(\C=N\NC(=O)C2CN(C(=O)C2)c2cc(C)c(c(C)c2)S(N)(=O)=O)cc1 InChI=1S/C21H24N4O5S/c1-13-8-17(9-14(2)20(13)31(22,28)29)25-12-16(10-19(25)26)21(27)24-23-11-15-4-6-18(30-3)7-5-15/h4-9,11,16H,10,12H2,1-3H3,(H,24,27)(H2,22,28,29)/b23-11+ QXVXBVRIVQJMHL-FOKLQQMPSA-N 50503800 CHEMBL4558235 Carbonic anhydrase 4 Homo sapiens 0.100000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503800&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155557596 440712385 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226789 NS(=O)(=O)c1ccc(NC(=O)C2CN(C(=O)C2)c2ccc(Br)cc2)cc1 InChI=1S/C17H16BrN3O4S/c18-12-1-5-14(6-2-12)21-10-11(9-16(21)22)17(23)20-13-3-7-15(8-4-13)26(19,24)25/h1-8,11H,9-10H2,(H,20,23)(H2,19,24,25) VARWAVMNTFHJRR-UHFFFAOYSA-N 50503791 CHEMBL4570038 Carbonic anhydrase 4 Homo sapiens 1.3 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503791&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 20109205 440712376 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226803 Cc1cc(N2CC(CC2=O)C(=O)N\N=C\c2ccc(cc2)[N+]([O-])=O)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C20H20ClN5O6S/c1-11-7-16(18(21)12(2)19(11)33(22,31)32)25-10-14(8-17(25)27)20(28)24-23-9-13-3-5-15(6-4-13)26(29)30/h3-7,9,14H,8,10H2,1-2H3,(H,24,28)(H2,22,31,32)/b23-9+ VNBKZNNTVDGEAL-NUGSKGIGSA-N 50503786 CHEMBL4555622 Carbonic anhydrase 4 Homo sapiens 480 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503786&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155556996 440712371 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226804 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)c1n[nH]c(=S)o1 InChI=1S/C14H16N4O4S2/c1-7-3-10(4-8(2)12(7)24(15,20)21)18-6-9(5-11(18)19)13-16-17-14(23)22-13/h3-4,9H,5-6H2,1-2H3,(H,17,23)(H2,15,20,21) UDYCPRDAOLRKNS-UHFFFAOYSA-N 50503802 CHEMBL4570253 Carbonic anhydrase 4 Homo sapiens 6900 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503802&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155562947 440712387 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226806 NS(=O)(=O)c1ccc(NC(=O)C2CN(C(=O)C2)c2ccc(Br)cc2)cc1 InChI=1S/C17H16BrN3O4S/c18-12-1-5-14(6-2-12)21-10-11(9-16(21)22)17(23)20-13-3-7-15(8-4-13)26(19,24)25/h1-8,11H,9-10H2,(H,20,23)(H2,19,24,25) VARWAVMNTFHJRR-UHFFFAOYSA-N 50503791 CHEMBL4570038 Carbonic anhydrase 4 Homo sapiens 5600 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503791&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 20109205 440712376 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226807 Cc1cc(N2CC(CC2=O)C(O)=O)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C13H15ClN2O5S/c1-6-3-9(11(14)7(2)12(6)22(15,20)21)16-5-8(13(18)19)4-10(16)17/h3,8H,4-5H2,1-2H3,(H,18,19)(H2,15,20,21) PXKOFARYUUHCAL-UHFFFAOYSA-N 50503789 CHEMBL4452277 Carbonic anhydrase 4 Homo sapiens 360 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503789&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155522813 440712374 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273504 Fc1cccc2c1NC(=O)NS2(=O)=O InChI=1S/C7H5FN2O3S/c8-4-2-1-3-5-6(4)9-7(11)10-14(5,12)13/h1-3H,(H2,9,10,11) ORDOVOAXLGQUIE-UHFFFAOYSA-N 50519802 CHEMBL4453203 Carbonic anhydrase 4 Homo sapiens 461 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519802&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 82078731 440728384 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273505 CN1C(=O)NS(=O)(=O)c2ccccc12 InChI=1S/C8H8N2O3S/c1-10-6-4-2-3-5-7(6)14(12,13)9-8(10)11/h2-5H,1H3,(H,9,11) RQCMUVKZNMGOOY-UHFFFAOYSA-N 50519803 CHEMBL4521083 Carbonic anhydrase 4 Homo sapiens 3459 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519803&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search PX7 6U4T,6U4Q,6UH0 11615432 440728385 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273510 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273521 O=C1Nc2ccccc2S(=O)(=O)N1 InChI=1S/C7H6N2O3S/c10-7-8-5-3-1-2-4-6(5)13(11,12)9-7/h1-4H,(H2,8,9,10) QCHXXLQQTWUIRQ-UHFFFAOYSA-N 50207539 CHEMBL3976024 Carbonic anhydrase 4 Homo sapiens 675 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50207539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50207539&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 474578 375981750 CHEMBL3976024 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273522 Cc1ccc2NC(=O)NS(=O)(=O)c2c1 InChI=1S/C8H8N2O3S/c1-5-2-3-6-7(4-5)14(12,13)10-8(11)9-6/h2-4H,1H3,(H2,9,10,11) ZZPWPCXHSCJIEN-UHFFFAOYSA-N 50519813 CHEMBL4553482 Carbonic anhydrase 4 Homo sapiens 897 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519813&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10081897 440728395 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273523 Cc1cc(C)c2NC(=O)NS(=O)(=O)c2c1 InChI=1S/C9H10N2O3S/c1-5-3-6(2)8-7(4-5)15(13,14)11-9(12)10-8/h3-4H,1-2H3,(H2,10,11,12) OLDBDPLNTRFOOO-UHFFFAOYSA-N 50519804 CHEMBL4587101 Carbonic anhydrase 4 Homo sapiens 1637 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519804&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search Q77 6UGN,6UGO 82080973 440728386 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273524 Cc1ccc(C)c2c1NC(=O)NS2(=O)=O InChI=1S/C9H10N2O3S/c1-5-3-4-6(2)8-7(5)10-9(12)11-15(8,13)14/h3-4H,1-2H3,(H2,10,11,12) FQOBLLWUIGZKLR-UHFFFAOYSA-N 50519814 CHEMBL4435951 Carbonic anhydrase 4 Homo sapiens 1427 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519814&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10059582 440728396 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273525 Fc1ccc2NC(=O)NS(=O)(=O)c2c1 InChI=1S/C7H5FN2O3S/c8-4-1-2-5-6(3-4)14(12,13)10-7(11)9-5/h1-3H,(H2,9,10,11) ITUAGWGFDMMEMY-UHFFFAOYSA-N 50519811 CHEMBL4571323 Carbonic anhydrase 4 Homo sapiens 709 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519811&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search Q71 6UGR,6UGZ 11096006 440728393 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273526 Clc1ccc2NC(=O)NS(=O)(=O)c2c1 InChI=1S/C7H5ClN2O3S/c8-4-1-2-5-6(3-4)14(12,13)10-7(11)9-5/h1-3H,(H2,9,10,11) SDCJBUKXFVQVKG-UHFFFAOYSA-N 50519815 CHEMBL4586255 Carbonic anhydrase 4 Homo sapiens 1748 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519815&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10331524 440728397 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273527 Brc1ccc2NC(=O)NS(=O)(=O)c2c1 InChI=1S/C7H5BrN2O3S/c8-4-1-2-5-6(3-4)14(12,13)10-7(11)9-5/h1-3H,(H2,9,10,11) VTJWRYVVYUVXJO-UHFFFAOYSA-N 50519816 CHEMBL4539322 Carbonic anhydrase 4 Homo sapiens 1557 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519816&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10107532 440728398 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273528 COc1ccc2NC(=O)NS(=O)(=O)c2c1 InChI=1S/C8H8N2O4S/c1-14-5-2-3-6-7(4-5)15(12,13)10-8(11)9-6/h2-4H,1H3,(H2,9,10,11) XMLNLKMCNNIYHI-UHFFFAOYSA-N 50519805 CHEMBL4531304 Carbonic anhydrase 4 Homo sapiens 1945 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519805&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12528490 440728387 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273529 O=C1Nc2c(ccc3ccccc23)S(=O)(=O)N1 InChI=1S/C11H8N2O3S/c14-11-12-10-8-4-2-1-3-7(8)5-6-9(10)17(15,16)13-11/h1-6H,(H2,12,13,14) KVDCOZGHMLQVAQ-UHFFFAOYSA-N 50519817 CHEMBL4474233 Carbonic anhydrase 4 Homo sapiens 2674 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519817&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155537018 440728399 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273530 O=C1NS(=O)(=O)c2cccc3CCN1c23 InChI=1S/C9H8N2O3S/c12-9-10-15(13,14)7-3-1-2-6-4-5-11(9)8(6)7/h1-3H,4-5H2,(H,10,12) MIKKSTQXSZURNV-UHFFFAOYSA-N 50519807 CHEMBL4449637 Carbonic anhydrase 4 Homo sapiens 3894 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519807&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 14024589 440728389 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273531 OC(=O)c1cccc2c1NC(=O)NS2(=O)=O InChI=1S/C8H6N2O5S/c11-7(12)4-2-1-3-5-6(4)9-8(13)10-16(5,14)15/h1-3H,(H,11,12)(H2,9,10,13) LGZAJTNKYNWYMD-UHFFFAOYSA-N 50519808 CHEMBL4440314 Carbonic anhydrase 4 Homo sapiens 380 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519808&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 91811067 440728390 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273532 O=C1NS(=O)(=O)c2ccccc12 InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9) CVHZOJJKTDOEJC-UHFFFAOYSA-N 29278 CHEMBL310671::Garantose::SAC::Saccharimide::Saccharin Carbonic anhydrase 4 Homo sapiens 7920 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29278&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search LSA 2Q38,7WJV,5RSP,4RIV,6FJJ,4N1O,3SRK,2Q1B 5143 81054707 32111 CHEMBL310671 5432 C12283 ZINC02560357 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273533 NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(F)cc2)cc1 InChI=1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18) YJQZNWPYLCNRLP-UHFFFAOYSA-N 50334354 4-(3-(4-fluorophenyl)ureido)benzenesulfonamide::4-{[(4'-Fluorophenyl)carbamoyl]amino}benzenesulfonamide::4-{[(4-fluorophenyl)carbamoyl]amino}benzenesulfonamide::CHEMBL1615281 Carbonic anhydrase 4 Homo sapiens 286 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334354&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search WWZ 3N4B,7NWY,5JN3 310360 125084456 CHEMBL1615281 ZINC01752601 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226988 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(O)=O InChI=1S/C13H16N2O5S/c1-7-3-10(4-8(2)12(7)21(14,19)20)15-6-9(13(17)18)5-11(15)16/h3-4,9H,5-6H2,1-2H3,(H,17,18)(H2,14,19,20) LYVVRBXEBODTED-UHFFFAOYSA-N 50503775 CHEMBL4439909 Carbonic anhydrase 4 Homo sapiens 0.270000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503775&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155514238 440712360 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226989 Cc1cc(N2CC(CC2=O)C(O)=O)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C13H15ClN2O5S/c1-6-3-9(11(14)7(2)12(6)22(15,20)21)16-5-8(13(18)19)4-10(16)17/h3,8H,4-5H2,1-2H3,(H,18,19)(H2,15,20,21) PXKOFARYUUHCAL-UHFFFAOYSA-N 50503789 CHEMBL4452277 Carbonic anhydrase 4 Homo sapiens 0.130000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503789&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155522813 440712374 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226990 COC(=O)C1CN(C(=O)C1)c1cc(C)c(c(C)c1)S(N)(=O)=O InChI=1S/C14H18N2O5S/c1-8-4-11(5-9(2)13(8)22(15,19)20)16-7-10(6-12(16)17)14(18)21-3/h4-5,10H,6-7H2,1-3H3,(H2,15,19,20) DDHTXLSWEKZONS-UHFFFAOYSA-N 50503817 CHEMBL4441652 Carbonic anhydrase 4 Homo sapiens 0.310000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503817&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155515322 440712402 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226991 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)NN InChI=1S/C13H18N4O4S/c1-7-3-10(4-8(2)12(7)22(15,20)21)17-6-9(5-11(17)18)13(19)16-14/h3-4,9H,5-6,14H2,1-2H3,(H,16,19)(H2,15,20,21) ZXIVZPANALWVLV-UHFFFAOYSA-N 50503779 CHEMBL4449430 Carbonic anhydrase 4 Homo sapiens 0.420000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503779&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155520598 440712364 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226992 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)N\N=C\c1ccccc1 InChI=1S/C20H22N4O4S/c1-13-8-17(9-14(2)19(13)29(21,27)28)24-12-16(10-18(24)25)20(26)23-22-11-15-6-4-3-5-7-15/h3-9,11,16H,10,12H2,1-2H3,(H,23,26)(H2,21,27,28)/b22-11+ NEEUKYCSJKNGPX-SSDVNMTOSA-N 50503799 CHEMBL4474833 Carbonic anhydrase 4 Homo sapiens 0.230000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503799&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155537230 440712384 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226993 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)N\N=C\c1ccc(cc1)[N+]([O-])=O InChI=1S/C20H21N5O6S/c1-12-7-17(8-13(2)19(12)32(21,30)31)24-11-15(9-18(24)26)20(27)23-22-10-14-3-5-16(6-4-14)25(28)29/h3-8,10,15H,9,11H2,1-2H3,(H,23,27)(H2,21,30,31)/b22-10+ YFQTYSFYANGBFX-LSHDLFTRSA-N 50503776 CHEMBL4560953 Carbonic anhydrase 4 Homo sapiens 0.220000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503776&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155558412 440712361 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226994 Cc1cc(N2CC(CC2=O)C(=O)N\N=C\c2ccc(cc2)[N+]([O-])=O)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C20H20ClN5O6S/c1-11-7-16(18(21)12(2)19(11)33(22,31)32)25-10-14(8-17(25)27)20(28)24-23-9-13-3-5-15(6-4-13)26(29)30/h3-7,9,14H,8,10H2,1-2H3,(H,24,28)(H2,22,31,32)/b23-9+ VNBKZNNTVDGEAL-NUGSKGIGSA-N 50503786 CHEMBL4555622 Carbonic anhydrase 4 Homo sapiens 0.170000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503786&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155556996 440712371 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226995 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)N\N=C\c1ccc(Br)cc1 InChI=1S/C20H21BrN4O4S/c1-12-7-17(8-13(2)19(12)30(22,28)29)25-11-15(9-18(25)26)20(27)24-23-10-14-3-5-16(21)6-4-14/h3-8,10,15H,9,11H2,1-2H3,(H,24,27)(H2,22,28,29)/b23-10+ FZSUWIXCCPYYTK-AUEPDCJTSA-N 50503778 CHEMBL4443078 Carbonic anhydrase 4 Homo sapiens 0.910000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503778&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155516215 440712363 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226996 COc1ccc(\C=N\NC(=O)C2CN(C(=O)C2)c2cc(C)c(c(C)c2Cl)S(N)(=O)=O)cc1 InChI=1S/C21H23ClN4O5S/c1-12-8-17(19(22)13(2)20(12)32(23,29)30)26-11-15(9-18(26)27)21(28)25-24-10-14-4-6-16(31-3)7-5-14/h4-8,10,15H,9,11H2,1-3H3,(H,25,28)(H2,23,29,30)/b24-10+ AVJKBYLJCIHZOZ-YSURURNPSA-N 50503808 CHEMBL4441730 Carbonic anhydrase 4 Homo sapiens 0.062000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503808&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155515477 440712393 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226997 Cc1cc(C)n(n1)C(=O)C1CN(C(=O)C1)c1cc(C)c(c(C)c1)S(N)(=O)=O InChI=1S/C18H22N4O4S/c1-10-5-15(6-11(2)17(10)27(19,25)26)21-9-14(8-16(21)23)18(24)22-13(4)7-12(3)20-22/h5-7,14H,8-9H2,1-4H3,(H2,19,25,26) QAFGXLLHNLFWJB-UHFFFAOYSA-N 50503809 CHEMBL4567916 Carbonic anhydrase 4 Homo sapiens 0.280000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503809&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155560681 440712394 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226998 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)NN1CC(CC1=O)C(O)=O InChI=1S/C18H22N4O7S/c1-9-3-13(4-10(2)16(9)30(19,28)29)21-7-11(5-14(21)23)17(25)20-22-8-12(18(26)27)6-15(22)24/h3-4,11-12H,5-8H2,1-2H3,(H,20,25)(H,26,27)(H2,19,28,29) TZMUZODFGLCMBN-UHFFFAOYSA-N 50503783 CHEMBL4590754 Carbonic anhydrase 4 Homo sapiens 0.420000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503783&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155568583 440712368 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51226999 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)NNC(=S)Nc1ccccc1 InChI=1S/C20H23N5O4S2/c1-12-8-16(9-13(2)18(12)31(21,28)29)25-11-14(10-17(25)26)19(27)23-24-20(30)22-15-6-4-3-5-7-15/h3-9,14H,10-11H2,1-2H3,(H,23,27)(H2,21,28,29)(H2,22,24,30) OWIMCWHOYBJYPJ-UHFFFAOYSA-N 50503812 CHEMBL4577993 Carbonic anhydrase 4 Homo sapiens 0.320000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503812&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155564683 440712397 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227000 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)c1n[nH]c(=S)n1-c1ccccc1 InChI=1S/C20H21N5O3S2/c1-12-8-16(9-13(2)18(12)30(21,27)28)24-11-14(10-17(24)26)19-22-23-20(29)25(19)15-6-4-3-5-7-15/h3-9,14H,10-11H2,1-2H3,(H,23,29)(H2,21,27,28) UBNGBOPIZHLQTJ-UHFFFAOYSA-N 50503814 CHEMBL4558457 Carbonic anhydrase 4 Homo sapiens 0.320000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503814&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155557453 440712399 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227001 COC(=O)C1CN(C(=O)C1)c1cc(C)c(cc1C)S(N)(=O)=O InChI=1S/C14H18N2O5S/c1-8-5-12(22(15,19)20)9(2)4-11(8)16-7-10(6-13(16)17)14(18)21-3/h4-5,10H,6-7H2,1-3H3,(H2,15,19,20) GPAVHWNLQIBJCP-UHFFFAOYSA-N 50503787 CHEMBL4465027 Carbonic anhydrase 4 Homo sapiens 2.2 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503787&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155530944 440712372 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227002 Cc1cc(c(C)cc1N1CC(CC1=O)C(=O)NN)S(N)(=O)=O InChI=1S/C13H18N4O4S/c1-7-4-11(22(15,20)21)8(2)3-10(7)17-6-9(5-12(17)18)13(19)16-14/h3-4,9H,5-6,14H2,1-2H3,(H,16,19)(H2,15,20,21) QKRANWMIHBZHSL-UHFFFAOYSA-N 50503782 CHEMBL4454574 Carbonic anhydrase 4 Homo sapiens 3.0 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503782&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155524252 440712367 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227003 Cc1cc(c(C)cc1N1CC(CC1=O)C(=O)N\N=C\c1ccc(cc1)[N+]([O-])=O)S(N)(=O)=O InChI=1S/C20H21N5O6S/c1-12-8-18(32(21,30)31)13(2)7-17(12)24-11-15(9-19(24)26)20(27)23-22-10-14-3-5-16(6-4-14)25(28)29/h3-8,10,15H,9,11H2,1-2H3,(H,23,27)(H2,21,30,31)/b22-10+ GGHMHTCINUOUQI-LSHDLFTRSA-N 50503788 CHEMBL4555586 Carbonic anhydrase 4 Homo sapiens 3.7 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503788&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155556702 440712373 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227004 NS(=O)(=O)c1ccc(NC(=O)C2CN(C(=O)C2)c2ccccc2)cc1 InChI=1S/C17H17N3O4S/c18-25(23,24)15-8-6-13(7-9-15)19-17(22)12-10-16(21)20(11-12)14-4-2-1-3-5-14/h1-9,12H,10-11H2,(H,19,22)(H2,18,23,24) NUJALWVOCRMDBE-UHFFFAOYSA-N 50503815 CHEMBL4516072 Carbonic anhydrase 4 Homo sapiens 0.190000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503815&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 17080567 440712400 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227005 NS(=O)(=O)c1ccc(NC(=O)C2CN(C(=O)C2)c2cccc(Br)c2)cc1 InChI=1S/C17H16BrN3O4S/c18-12-2-1-3-14(9-12)21-10-11(8-16(21)22)17(23)20-13-4-6-15(7-5-13)26(19,24)25/h1-7,9,11H,8,10H2,(H,20,23)(H2,19,24,25) XRVRIYCPWZRODG-UHFFFAOYSA-N 50503810 CHEMBL4462447 Carbonic anhydrase 4 Homo sapiens 0.180000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503810&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155529158 440712395 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227006 COC(=O)C1CN(C(=O)C1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C12H14N2O5S/c1-19-12(16)8-6-11(15)14(7-8)9-2-4-10(5-3-9)20(13,17)18/h2-5,8H,6-7H2,1H3,(H2,13,17,18) ILHVIROQSRNVIQ-UHFFFAOYSA-N 50503811 CHEMBL4567746 Carbonic anhydrase 4 Homo sapiens 0.270000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503811&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 50873964 440712396 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227007 NNC(=O)C1CN(C(=O)C1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C11H14N4O4S/c12-14-11(17)7-5-10(16)15(6-7)8-1-3-9(4-2-8)20(13,18)19/h1-4,7H,5-6,12H2,(H,14,17)(H2,13,18,19) UCLAABICIDKCQY-UHFFFAOYSA-N 50503792 CHEMBL4593434 Carbonic anhydrase 4 Homo sapiens 0.400000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503792&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129885267 440712377 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273603 Clc1cccc2c1NC(=O)NS2(=O)=O InChI=1S/C7H5ClN2O3S/c8-4-2-1-3-5-6(4)9-7(11)10-14(5,12)13/h1-3H,(H2,9,10,11) LHWAXFMPTHUVQY-UHFFFAOYSA-N 50519806 CHEMBL4550437 Carbonic anhydrase 4 Homo sapiens 1031 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519806&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search Q7A 6UGP,6UGQ 10220266 440728388 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273604 Oc1ccc2NC(=O)NS(=O)(=O)c2c1 InChI=1S/C7H6N2O4S/c10-4-1-2-5-6(3-4)14(12,13)9-7(11)8-5/h1-3,10H,(H2,8,9,11) DEWYNLFUFLFKHV-UHFFFAOYSA-N 50519820 CHEMBL4444406 Carbonic anhydrase 4 Homo sapiens 452 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519820&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 147348395 440728402 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273617 Cc1cccc2c1NC(=O)NS2(=O)=O InChI=1S/C8H8N2O3S/c1-5-3-2-4-6-7(5)9-8(11)10-14(6,12)13/h2-4H,1H3,(H2,9,10,11) RISXVHCQQZRPFT-UHFFFAOYSA-N 50519809 CHEMBL4437873 Carbonic anhydrase 4 Homo sapiens 1228 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519809&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12528487 440728391 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273618 Cc1cc(C)c2c(NC(=O)NS2(=O)=O)c1 InChI=1S/C9H10N2O3S/c1-5-3-6(2)8-7(4-5)10-9(12)11-15(8,13)14/h3-4H,1-2H3,(H2,10,11,12) RCGNXQUBSZXYBL-UHFFFAOYSA-N 50519818 CHEMBL4536306 Carbonic anhydrase 4 Homo sapiens 2692 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519818&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 15230629 440728400 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273619 Brc1cccc2c1NC(=O)NS2(=O)=O InChI=1S/C7H5BrN2O3S/c8-4-2-1-3-5-6(4)9-7(11)10-14(5,12)13/h1-3H,(H2,9,10,11) UNWFVIMGKIDJKB-UHFFFAOYSA-N 50519810 CHEMBL4542190 Carbonic anhydrase 4 Homo sapiens 854 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519810&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10016330 440728392 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273620 CN1C(=O)NS(=O)(=O)c2cc(Cl)ccc12 InChI=1S/C8H7ClN2O3S/c1-11-6-3-2-5(9)4-7(6)15(13,14)10-8(11)12/h2-4H,1H3,(H,10,12) JIJQUHAXUWATKU-UHFFFAOYSA-N 50519819 CHEMBL4469385 Carbonic anhydrase 4 Homo sapiens 5885 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519819&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 26598995 440728401 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51273621 OC(=O)c1ccc2NC(=O)NS(=O)(=O)c2c1 InChI=1S/C8H6N2O5S/c11-7(12)4-1-2-5-6(3-4)16(14,15)10-8(13)9-5/h1-3H,(H,11,12)(H2,9,10,13) IUFVBLNYWMTPOB-UHFFFAOYSA-N 50519812 CHEMBL4442867 Carbonic anhydrase 4 Homo sapiens 76 ChEMBL 10.1021/acs.jmedchem.9b01669 10.7270/Q2TX3JR0 31794211 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519812&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 11287957 440728394 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227142 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(O)=O InChI=1S/C13H16N2O5S/c1-7-3-10(4-8(2)12(7)21(14,19)20)15-6-9(13(17)18)5-11(15)16/h3-4,9H,5-6H2,1-2H3,(H,17,18)(H2,14,19,20) LYVVRBXEBODTED-UHFFFAOYSA-N 50503775 CHEMBL4439909 Carbonic anhydrase 4 Homo sapiens 5900 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503775&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155514238 440712360 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227143 COC(=O)C1CN(C(=O)C1)c1cc(C)c(c(C)c1Cl)S(N)(=O)=O InChI=1S/C14H17ClN2O5S/c1-7-4-10(12(15)8(2)13(7)23(16,20)21)17-6-9(5-11(17)18)14(19)22-3/h4,9H,5-6H2,1-3H3,(H2,16,20,21) DNALKYILSFHWTG-UHFFFAOYSA-N 50503777 CHEMBL4473602 Carbonic anhydrase 4 Homo sapiens 1000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503777&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155536281 440712362 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227144 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)NN InChI=1S/C13H18N4O4S/c1-7-3-10(4-8(2)12(7)22(15,20)21)17-6-9(5-11(17)18)13(19)16-14/h3-4,9H,5-6,14H2,1-2H3,(H,16,19)(H2,15,20,21) ZXIVZPANALWVLV-UHFFFAOYSA-N 50503779 CHEMBL4449430 Carbonic anhydrase 4 Homo sapiens 9100 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503779&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155520598 440712364 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227145 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)N\N=C\c1ccccc1 InChI=1S/C20H22N4O4S/c1-13-8-17(9-14(2)19(13)29(21,27)28)24-12-16(10-18(24)25)20(26)23-22-11-15-6-4-3-5-7-15/h3-9,11,16H,10,12H2,1-2H3,(H,23,26)(H2,21,27,28)/b22-11+ NEEUKYCSJKNGPX-SSDVNMTOSA-N 50503799 CHEMBL4474833 Carbonic anhydrase 4 Homo sapiens 5000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503799&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155537230 440712384 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227146 Cc1cc(N2CC(CC2=O)C(=O)N\N=C\c2ccccc2)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C20H21ClN4O4S/c1-12-8-16(18(21)13(2)19(12)30(22,28)29)25-11-15(9-17(25)26)20(27)24-23-10-14-6-4-3-5-7-14/h3-8,10,15H,9,11H2,1-2H3,(H,24,27)(H2,22,28,29)/b23-10+ QUFIXMHHYPGTGH-AUEPDCJTSA-N 50503795 CHEMBL4463683 Carbonic anhydrase 4 Homo sapiens 770 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503795&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155530244 440712380 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227147 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)N\N=C\c1ccc(Br)cc1 InChI=1S/C20H21BrN4O4S/c1-12-7-17(8-13(2)19(12)30(22,28)29)25-11-15(9-18(25)26)20(27)24-23-10-14-3-5-16(21)6-4-14/h3-8,10,15H,9,11H2,1-2H3,(H,24,27)(H2,22,28,29)/b23-10+ FZSUWIXCCPYYTK-AUEPDCJTSA-N 50503778 CHEMBL4443078 Carbonic anhydrase 4 Homo sapiens 20000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503778&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155516215 440712363 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227148 Cc1cc(N2CC(CC2=O)C(=O)N\N=C\c2ccc(Br)cc2)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C20H20BrClN4O4S/c1-11-7-16(18(22)12(2)19(11)31(23,29)30)26-10-14(8-17(26)27)20(28)25-24-9-13-3-5-15(21)6-4-13/h3-7,9,14H,8,10H2,1-2H3,(H,25,28)(H2,23,29,30)/b24-9+ SPSNHNYTLIKLAR-PGGKNCGUSA-N 50503780 CHEMBL4475315 Carbonic anhydrase 4 Homo sapiens 340 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503780&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155537380 440712365 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227149 COc1ccc(\C=N\NC(=O)C2CN(C(=O)C2)c2cc(C)c(c(C)c2)S(N)(=O)=O)cc1 InChI=1S/C21H24N4O5S/c1-13-8-17(9-14(2)20(13)31(22,28)29)25-12-16(10-19(25)26)21(27)24-23-11-15-4-6-18(30-3)7-5-15/h4-9,11,16H,10,12H2,1-3H3,(H,24,27)(H2,22,28,29)/b23-11+ QXVXBVRIVQJMHL-FOKLQQMPSA-N 50503800 CHEMBL4558235 Carbonic anhydrase 4 Homo sapiens 2200 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503800&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155557596 440712385 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227150 Cc1cc(C)n(n1)C(=O)C1CN(C(=O)C1)c1cc(C)c(c(C)c1)S(N)(=O)=O InChI=1S/C18H22N4O4S/c1-10-5-15(6-11(2)17(10)27(19,25)26)21-9-14(8-16(21)23)18(24)22-13(4)7-12(3)20-22/h5-7,14H,8-9H2,1-4H3,(H2,19,25,26) QAFGXLLHNLFWJB-UHFFFAOYSA-N 50503809 CHEMBL4567916 Carbonic anhydrase 4 Homo sapiens 6000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503809&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155560681 440712394 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227151 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)NN1CC(CC1=O)C(O)=O InChI=1S/C18H22N4O7S/c1-9-3-13(4-10(2)16(9)30(19,28)29)21-7-11(5-14(21)23)17(25)20-22-8-12(18(26)27)6-15(22)24/h3-4,11-12H,5-8H2,1-2H3,(H,20,25)(H,26,27)(H2,19,28,29) TZMUZODFGLCMBN-UHFFFAOYSA-N 50503783 CHEMBL4590754 Carbonic anhydrase 4 Homo sapiens 9100 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503783&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155568583 440712368 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227191 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)c1n[nH]c(=S)n1-c1ccccc1 InChI=1S/C20H21N5O3S2/c1-12-8-16(9-13(2)18(12)30(21,27)28)24-11-14(10-17(24)26)19-22-23-20(29)25(19)15-6-4-3-5-7-15/h3-9,14H,10-11H2,1-2H3,(H,23,29)(H2,21,27,28) UBNGBOPIZHLQTJ-UHFFFAOYSA-N 50503814 CHEMBL4558457 Carbonic anhydrase 4 Homo sapiens 7000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503814&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155557453 440712399 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227192 Cc1cc(c(C)cc1N1CC(CC1=O)C(O)=O)S(N)(=O)=O InChI=1S/C13H16N2O5S/c1-7-4-11(21(14,19)20)8(2)3-10(7)15-6-9(13(17)18)5-12(15)16/h3-4,9H,5-6H2,1-2H3,(H,17,18)(H2,14,19,20) MTHLUECOFDPPBS-UHFFFAOYSA-N 50503794 CHEMBL4577083 Carbonic anhydrase 4 Homo sapiens 19000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503794&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155553815 440712379 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227193 COC(=O)C1CN(C(=O)C1)c1cc(C)c(cc1C)S(N)(=O)=O InChI=1S/C14H18N2O5S/c1-8-5-12(22(15,19)20)9(2)4-11(8)16-7-10(6-13(16)17)14(18)21-3/h4-5,10H,6-7H2,1-3H3,(H2,15,19,20) GPAVHWNLQIBJCP-UHFFFAOYSA-N 50503787 CHEMBL4465027 Carbonic anhydrase 4 Homo sapiens 10000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503787&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155530944 440712372 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227194 Cc1cc(c(C)cc1N1CC(CC1=O)C(=O)NN)S(N)(=O)=O InChI=1S/C13H18N4O4S/c1-7-4-11(22(15,20)21)8(2)3-10(7)17-6-9(5-12(17)18)13(19)16-14/h3-4,9H,5-6,14H2,1-2H3,(H,16,19)(H2,15,20,21) QKRANWMIHBZHSL-UHFFFAOYSA-N 50503782 CHEMBL4454574 Carbonic anhydrase 4 Homo sapiens 14000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503782&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155524252 440712367 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227195 NS(=O)(=O)c1ccc(NC(=O)C2CN(C(=O)C2)c2ccccc2)cc1 InChI=1S/C17H17N3O4S/c18-25(23,24)15-8-6-13(7-9-15)19-17(22)12-10-16(21)20(11-12)14-4-2-1-3-5-14/h1-9,12H,10-11H2,(H,19,22)(H2,18,23,24) NUJALWVOCRMDBE-UHFFFAOYSA-N 50503815 CHEMBL4516072 Carbonic anhydrase 4 Homo sapiens 850 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503815&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 17080567 440712400 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227196 NS(=O)(=O)c1ccc(NC(=O)C2CN(C(=O)C2)c2ccccc2Br)cc1 InChI=1S/C17H16BrN3O4S/c18-14-3-1-2-4-15(14)21-10-11(9-16(21)22)17(23)20-12-5-7-13(8-6-12)26(19,24)25/h1-8,11H,9-10H2,(H,20,23)(H2,19,24,25) BITDKWNMAVDYRW-UHFFFAOYSA-N 50503806 CHEMBL4553790 Carbonic anhydrase 4 Homo sapiens 400 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503806&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155555383 440712391 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227197 NS(=O)(=O)c1ccc(cc1)N1CC(CC1=O)C(O)=O InChI=1S/C11H12N2O5S/c12-19(17,18)9-3-1-8(2-4-9)13-6-7(11(15)16)5-10(13)14/h1-4,7H,5-6H2,(H,15,16)(H2,12,17,18) PQTYDOPYQOAELL-UHFFFAOYSA-N 50503801 CHEMBL4446249 Carbonic anhydrase 4 Homo sapiens 2500 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503801&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5144111 440712386 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227198 NNC(=O)C1CN(C(=O)C1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C11H14N4O4S/c12-14-11(17)7-5-10(16)15(6-7)8-1-3-9(4-2-8)20(13,18)19/h1-4,7H,5-6,12H2,(H,14,17)(H2,13,18,19) UCLAABICIDKCQY-UHFFFAOYSA-N 50503792 CHEMBL4593434 Carbonic anhydrase 4 Homo sapiens 2200 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503792&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 129885267 440712377 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227245 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)N\N=C\c1ccc(Cl)cc1 InChI=1S/C20H21ClN4O4S/c1-12-7-17(8-13(2)19(12)30(22,28)29)25-11-15(9-18(25)26)20(27)24-23-10-14-3-5-16(21)6-4-14/h3-8,10,15H,9,11H2,1-2H3,(H,24,27)(H2,22,28,29)/b23-10+ VILBOPLLOHPBBF-AUEPDCJTSA-N 50503807 CHEMBL4587295 Carbonic anhydrase 4 Homo sapiens 0.830000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503807&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155566343 440712392 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227246 NS(=O)(=O)c1ccc(NC(=O)C2CN(C(=O)C2)c2ccccc2Br)cc1 InChI=1S/C17H16BrN3O4S/c18-14-3-1-2-4-15(14)21-10-11(9-16(21)22)17(23)20-12-5-7-13(8-6-12)26(19,24)25/h1-8,11H,9-10H2,(H,20,23)(H2,19,24,25) BITDKWNMAVDYRW-UHFFFAOYSA-N 50503806 CHEMBL4553790 Carbonic anhydrase 4 Homo sapiens 0.089000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503806&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155555383 440712391 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227250 COC(=O)C1CN(C(=O)C1)c1cc(C)c(c(C)c1)S(N)(=O)=O InChI=1S/C14H18N2O5S/c1-8-4-11(5-9(2)13(8)22(15,19)20)16-7-10(6-12(16)17)14(18)21-3/h4-5,10H,6-7H2,1-3H3,(H2,15,19,20) DDHTXLSWEKZONS-UHFFFAOYSA-N 50503817 CHEMBL4441652 Carbonic anhydrase 4 Homo sapiens 6700 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503817&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155515322 440712402 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227251 Cc1cc(C)n(NC(=O)C2CN(C(=O)C2)c2cc(C)c(c(C)c2)S(N)(=O)=O)n1 InChI=1S/C18H23N5O4S/c1-10-5-15(6-11(2)17(10)28(19,26)27)22-9-14(8-16(22)24)18(25)21-23-13(4)7-12(3)20-23/h5-7,14H,8-9H2,1-4H3,(H,21,25)(H2,19,26,27) WPFRINFKBVFRCT-UHFFFAOYSA-N 50503796 CHEMBL4449149 Carbonic anhydrase 4 Homo sapiens 2000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503796&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155520500 440712381 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227254 COC(=O)C1CN(C(=O)C1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C12H14N2O5S/c1-19-12(16)8-6-11(15)14(7-8)9-2-4-10(5-3-9)20(13,17)18/h2-5,8H,6-7H2,1H3,(H2,13,17,18) ILHVIROQSRNVIQ-UHFFFAOYSA-N 50503811 CHEMBL4567746 Carbonic anhydrase 4 Homo sapiens 1500 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503811&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 50873964 440712396 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227297 Cc1cc(N2CC(CC2=O)C(=O)NN)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C13H17ClN4O4S/c1-6-3-9(11(14)7(2)12(6)23(16,21)22)18-5-8(4-10(18)19)13(20)17-15/h3,8H,4-5,15H2,1-2H3,(H,17,20)(H2,16,21,22) ZZBVZOGPOHYKDO-UHFFFAOYSA-N 50503790 CHEMBL4458989 Carbonic anhydrase 4 Homo sapiens 500 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503790&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155527199 440712375 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227298 Cc1cc(N2CC(CC2=O)C(=O)N\N=C\c2ccc(Cl)cc2)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C20H20Cl2N4O4S/c1-11-7-16(18(22)12(2)19(11)31(23,29)30)26-10-14(8-17(26)27)20(28)25-24-9-13-3-5-15(21)6-4-13/h3-7,9,14H,8,10H2,1-2H3,(H,25,28)(H2,23,29,30)/b24-9+ QNNLWBCXVKKVRW-PGGKNCGUSA-N 50503816 CHEMBL4573916 Carbonic anhydrase 4 Homo sapiens 510 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503816&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155563403 440712401 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227299 COc1ccc(\C=N\NC(=O)C2CN(C(=O)C2)c2cc(C)c(c(C)c2Cl)S(N)(=O)=O)cc1 InChI=1S/C21H23ClN4O5S/c1-12-8-17(19(22)13(2)20(12)32(23,29)30)26-11-15(9-18(26)27)21(28)25-24-10-14-4-6-16(31-3)7-5-14/h4-8,10,15H,9,11H2,1-3H3,(H,25,28)(H2,23,29,30)/b24-10+ AVJKBYLJCIHZOZ-YSURURNPSA-N 50503808 CHEMBL4441730 Carbonic anhydrase 4 Homo sapiens 180 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503808&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155515477 440712393 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227300 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)NNC(=S)Nc1ccccc1 InChI=1S/C20H23N5O4S2/c1-12-8-16(9-13(2)18(12)31(21,28)29)25-11-14(10-17(25)26)19(27)23-24-20(30)22-15-6-4-3-5-7-15/h3-9,14H,10-11H2,1-2H3,(H,23,27)(H2,21,28,29)(H2,22,24,30) OWIMCWHOYBJYPJ-UHFFFAOYSA-N 50503812 CHEMBL4577993 Carbonic anhydrase 4 Homo sapiens 6900 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503812&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155564683 440712397 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227305 Cc1cc(c(C)cc1N1CC(CC1=O)C(=O)N\N=C\c1ccc(cc1)[N+]([O-])=O)S(N)(=O)=O InChI=1S/C20H21N5O6S/c1-12-8-18(32(21,30)31)13(2)7-17(12)24-11-15(9-19(24)26)20(27)23-22-10-14-3-5-16(6-4-14)25(28)29/h3-8,10,15H,9,11H2,1-2H3,(H,23,27)(H2,21,30,31)/b22-10+ GGHMHTCINUOUQI-LSHDLFTRSA-N 50503788 CHEMBL4555586 Carbonic anhydrase 4 Homo sapiens 17000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503788&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155556702 440712373 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227306 Cc1cc(NC(=O)C2CN(C(=O)C2)c2ccccc2)cc(C)c1S(N)(=O)=O InChI=1S/C19H21N3O4S/c1-12-8-15(9-13(2)18(12)27(20,25)26)21-19(24)14-10-17(23)22(11-14)16-6-4-3-5-7-16/h3-9,14H,10-11H2,1-2H3,(H,21,24)(H2,20,25,26) XKSNHXULXLMTSO-UHFFFAOYSA-N 50503785 CHEMBL4448119 Carbonic anhydrase 4 Homo sapiens 6800 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503785&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155519746 440712370 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227307 NS(=O)(=O)c1ccc(cc1)N1CC(CC1=O)C(=O)N\N=C\c1ccccc1 InChI=1S/C18H18N4O4S/c19-27(25,26)16-8-6-15(7-9-16)22-12-14(10-17(22)23)18(24)21-20-11-13-4-2-1-3-5-13/h1-9,11,14H,10,12H2,(H,21,24)(H2,19,25,26)/b20-11+ BNOSIOACPICPJD-RGVLZGJSSA-N 50503805 CHEMBL4474251 Carbonic anhydrase 4 Homo sapiens 1300 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503805&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155536858 440712390 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227314 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)N\N=C\c1ccc(Cl)cc1 InChI=1S/C20H21ClN4O4S/c1-12-7-17(8-13(2)19(12)30(22,28)29)25-11-15(9-18(25)26)20(27)24-23-10-14-3-5-16(21)6-4-14/h3-8,10,15H,9,11H2,1-2H3,(H,24,27)(H2,22,28,29)/b23-10+ VILBOPLLOHPBBF-AUEPDCJTSA-N 50503807 CHEMBL4587295 Carbonic anhydrase 4 Homo sapiens 18000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503807&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155566343 440712392 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227316 Cc1cc(NCC(CC(O)=O)c2n[nH]c(=S)n2-c2ccccc2)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C20H22ClN5O4S2/c1-11-8-15(17(21)12(2)18(11)32(22,29)30)23-10-13(9-16(27)28)19-24-25-20(31)26(19)14-6-4-3-5-7-14/h3-8,13,23H,9-10H2,1-2H3,(H,25,31)(H,27,28)(H2,22,29,30) CVAPWQUGPIGKOD-UHFFFAOYSA-N 50503798 CHEMBL4517728 Carbonic anhydrase 4 Homo sapiens 10000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503798&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155541044 440712383 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227361 NS(=O)(=O)c1ccc(NC(=O)C2CN(C(=O)C2)c2cccc(Br)c2)cc1 InChI=1S/C17H16BrN3O4S/c18-12-2-1-3-14(9-12)21-10-11(8-16(21)22)17(23)20-13-4-6-15(7-5-13)26(19,24)25/h1-7,9,11H,8,10H2,(H,20,23)(H2,19,24,25) XRVRIYCPWZRODG-UHFFFAOYSA-N 50503810 CHEMBL4462447 Carbonic anhydrase 4 Homo sapiens 810 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503810&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155529158 440712395 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227400 Cc1cc(N2CC(CC2=O)C(=O)N\N=C\c2ccccc2)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C20H21ClN4O4S/c1-12-8-16(18(21)13(2)19(12)30(22,28)29)25-11-15(9-17(25)26)20(27)24-23-10-14-6-4-3-5-7-14/h3-8,10,15H,9,11H2,1-2H3,(H,24,27)(H2,22,28,29)/b23-10+ QUFIXMHHYPGTGH-AUEPDCJTSA-N 50503795 CHEMBL4463683 Carbonic anhydrase 4 Homo sapiens 0.270000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503795&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155530244 440712380 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227401 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)c1n[nH]c(=S)o1 InChI=1S/C14H16N4O4S2/c1-7-3-10(4-8(2)12(7)24(15,20)21)18-6-9(5-11(18)19)13-16-17-14(23)22-13/h3-4,9H,5-6H2,1-2H3,(H,17,23)(H2,15,20,21) UDYCPRDAOLRKNS-UHFFFAOYSA-N 50503802 CHEMBL4570253 Carbonic anhydrase 4 Homo sapiens 0.320000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503802&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155562947 440712387 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227402 Cc1cc(NC(=O)C2CN(C(=O)C2)c2ccccc2)cc(C)c1S(N)(=O)=O InChI=1S/C19H21N3O4S/c1-12-8-15(9-13(2)18(12)27(20,25)26)21-19(24)14-10-17(23)22(11-14)16-6-4-3-5-7-16/h3-9,14H,10-11H2,1-2H3,(H,21,24)(H2,20,25,26) XKSNHXULXLMTSO-UHFFFAOYSA-N 50503785 CHEMBL4448119 Carbonic anhydrase 4 Homo sapiens 0.310000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503785&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155519746 440712370 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223116 OB1OCc2ccc(NC(=O)CC(=O)Nc3ccc4COB(O)c4c3)cc12 InChI=1S/C17H16B2N2O6/c22-16(20-12-3-1-10-8-26-18(24)14(10)5-12)7-17(23)21-13-4-2-11-9-27-19(25)15(11)6-13/h1-6,24-25H,7-9H2,(H,20,22)(H,21,23) IXTVZIHDEVZCRN-UHFFFAOYSA-N 50502604 CHEMBL4575821 Carbonic anhydrase 4 Homo sapiens 6276 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502604&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155563908 440711189 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223117 OB1OCc2ccc(cc12)\N=C\c1ccc(\C=N\c2ccc3COB(O)c3c2)s1 InChI=1S/C20H16B2N2O4S/c25-21-19-7-15(3-1-13(19)11-27-21)23-9-17-5-6-18(29-17)10-24-16-4-2-14-12-28-22(26)20(14)8-16/h1-10,25-26H,11-12H2/b23-9+,24-10+ ZIDJLFURKBSKJY-WDBPGAOMSA-N 50502605 CHEMBL4540966 Carbonic anhydrase 4 Homo sapiens 29700 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502605&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155551088 440711190 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223135 OB1OCc2ccc(NC(=O)CCC(=O)Nc3ccc4COB(O)c4c3)cc12 InChI=1S/C18H18B2N2O6/c23-17(21-13-3-1-11-9-27-19(25)15(11)7-13)5-6-18(24)22-14-4-2-12-10-28-20(26)16(12)8-14/h1-4,7-8,25-26H,5-6,9-10H2,(H,21,23)(H,22,24) YSKAMRMNCLLBOC-UHFFFAOYSA-N 50502609 CHEMBL4464046 Carbonic anhydrase 4 Homo sapiens 5239 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502609&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155529885 440711194 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223136 OB1OCc2ccc(NC(=O)C\C=C\CC(=O)Nc3ccc4COB(O)c4c3)cc12 InChI=1S/C20H20B2N2O6/c25-19(23-15-7-5-13-11-29-21(27)17(13)9-15)3-1-2-4-20(26)24-16-8-6-14-12-30-22(28)18(14)10-16/h1-2,5-10,27-28H,3-4,11-12H2,(H,23,25)(H,24,26)/b2-1+ RASPHMZISLFWFJ-OWOJBTEDSA-N 50502613 CHEMBL4542829 Carbonic anhydrase 4 Homo sapiens 12200 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502613&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155551935 440711198 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223137 OB1OCc2ccc(NC(=O)CC[C@H](NC(=O)OCc3ccccc3)C(=O)Nc3ccc4COB(O)c4c3)cc12 InChI=1S/C27H27B2N3O8/c33-25(30-20-8-6-18-15-39-28(36)22(18)12-20)11-10-24(32-27(35)38-14-17-4-2-1-3-5-17)26(34)31-21-9-7-19-16-40-29(37)23(19)13-21/h1-9,12-13,24,36-37H,10-11,14-16H2,(H,30,33)(H,31,34)(H,32,35)/t24-/m0/s1 RDOVCRGSBIJPRK-DEOSSOPVSA-N 50502614 CHEMBL4558585 Carbonic anhydrase 4 Homo sapiens 16200 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502614&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155557428 440711199 C03636 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223138 OB1OCc2ccc(NC3C(Nc4ccc5COB(O)c5c4)C(=O)C3=O)cc12 InChI=1S/C18H16B2N2O6/c23-17-15(21-11-3-1-9-7-27-19(25)13(9)5-11)16(18(17)24)22-12-4-2-10-8-28-20(26)14(10)6-12/h1-6,15-16,21-22,25-26H,7-8H2 SWHLCYPINMHIMQ-UHFFFAOYSA-N 50502615 CHEMBL4474840 Carbonic anhydrase 4 Homo sapiens 25600 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502615&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155537167 440711200 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223139 OB1OCc2ccc(cc12)C(O)=O InChI=1S/C8H7BO4/c10-8(11)5-1-2-6-4-13-9(12)7(6)3-5/h1-3,12H,4H2,(H,10,11) VXDGEAYKTHEYPI-UHFFFAOYSA-N 50502612 CHEMBL4539935 Carbonic anhydrase 4 Homo sapiens 1420 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502612&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search RZZ 7ATW 58404071 440711197 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223140 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 75 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227490 COC(=O)C1CN(C(=O)C1)c1cc(C)c(c(C)c1Cl)S(N)(=O)=O InChI=1S/C14H17ClN2O5S/c1-7-4-10(12(15)8(2)13(7)23(16,20)21)17-6-9(5-11(17)18)14(19)22-3/h4,9H,5-6H2,1-3H3,(H2,16,20,21) DNALKYILSFHWTG-UHFFFAOYSA-N 50503777 CHEMBL4473602 Carbonic anhydrase 4 Homo sapiens 0.360000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503777&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155536281 440712362 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227491 Cc1cc(N2CC(CC2=O)C(=O)N\N=C\c2ccc(Cl)cc2)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C20H20Cl2N4O4S/c1-11-7-16(18(22)12(2)19(11)31(23,29)30)26-10-14(8-17(26)27)20(28)25-24-9-13-3-5-15(21)6-4-13/h3-7,9,14H,8,10H2,1-2H3,(H,25,28)(H2,23,29,30)/b24-9+ QNNLWBCXVKKVRW-PGGKNCGUSA-N 50503816 CHEMBL4573916 Carbonic anhydrase 4 Homo sapiens 0.180000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503816&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155563403 440712401 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227492 Cc1cc(N2CC(CC2=O)C(=O)N\N=C\c2ccc(Br)cc2)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C20H20BrClN4O4S/c1-11-7-16(18(22)12(2)19(11)31(23,29)30)26-10-14(8-17(26)27)20(28)25-24-9-13-3-5-15(21)6-4-13/h3-7,9,14H,8,10H2,1-2H3,(H,25,28)(H2,23,29,30)/b24-9+ SPSNHNYTLIKLAR-PGGKNCGUSA-N 50503780 CHEMBL4475315 Carbonic anhydrase 4 Homo sapiens 0.120000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503780&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155537380 440712365 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227493 Cc1cc(C)n(NC(=O)C2CN(C(=O)C2)c2cc(C)c(c(C)c2)S(N)(=O)=O)n1 InChI=1S/C18H23N5O4S/c1-10-5-15(6-11(2)17(10)28(19,26)27)22-9-14(8-16(22)24)18(25)21-23-13(4)7-12(3)20-23/h5-7,14H,8-9H2,1-4H3,(H,21,25)(H2,19,26,27) WPFRINFKBVFRCT-UHFFFAOYSA-N 50503796 CHEMBL4449149 Carbonic anhydrase 4 Homo sapiens 0.093000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503796&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155520500 440712381 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227494 Cc1cc(c(C)cc1N1CC(CC1=O)C(O)=O)S(N)(=O)=O InChI=1S/C13H16N2O5S/c1-7-4-11(21(14,19)20)8(2)3-10(7)15-6-9(13(17)18)5-12(15)16/h3-4,9H,5-6H2,1-2H3,(H,17,18)(H2,14,19,20) MTHLUECOFDPPBS-UHFFFAOYSA-N 50503794 CHEMBL4577083 Carbonic anhydrase 4 Homo sapiens 4.1 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503794&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155553815 440712379 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227495 Cc1cc(c(C)cc1N1CC(CC1=O)C(=O)N\N=C\c1ccccc1)S(N)(=O)=O InChI=1S/C20H22N4O4S/c1-13-9-18(29(21,27)28)14(2)8-17(13)24-12-16(10-19(24)25)20(26)23-22-11-15-6-4-3-5-7-15/h3-9,11,16H,10,12H2,1-2H3,(H,23,26)(H2,21,27,28)/b22-11+ UHOITOKAAASPAH-SSDVNMTOSA-N 50503804 CHEMBL4444784 Carbonic anhydrase 4 Homo sapiens 1.6 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503804&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155517449 440712389 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227496 NS(=O)(=O)c1ccc(cc1)N1CC(CC1=O)C(O)=O InChI=1S/C11H12N2O5S/c12-19(17,18)9-3-1-8(2-4-9)13-6-7(11(15)16)5-10(13)14/h1-4,7H,5-6H2,(H,15,16)(H2,12,17,18) PQTYDOPYQOAELL-UHFFFAOYSA-N 50503801 CHEMBL4446249 Carbonic anhydrase 4 Homo sapiens 0.450000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503801&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5144111 440712386 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227497 NS(=O)(=O)c1ccc(cc1)N1CC(CC1=O)C(=O)N\N=C\c1ccccc1 InChI=1S/C18H18N4O4S/c19-27(25,26)16-8-6-15(7-9-16)22-12-14(10-17(22)23)18(24)21-20-11-13-4-2-1-3-5-13/h1-9,11,14H,10,12H2,(H,21,24)(H2,19,25,26)/b20-11+ BNOSIOACPICPJD-RGVLZGJSSA-N 50503805 CHEMBL4474251 Carbonic anhydrase 4 Homo sapiens 0.220000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503805&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155536858 440712390 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227511 Cc1cc(NCC(CC(O)=O)c2n[nH]c(=S)n2-c2ccccc2)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C20H22ClN5O4S2/c1-11-8-15(17(21)12(2)18(11)32(22,29)30)23-10-13(9-16(27)28)19-24-25-20(31)26(19)14-6-4-3-5-7-14/h3-8,13,23H,9-10H2,1-2H3,(H,25,31)(H,27,28)(H2,22,29,30) CVAPWQUGPIGKOD-UHFFFAOYSA-N 50503798 CHEMBL4517728 Carbonic anhydrase 4 Homo sapiens 0.450000 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503798&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155541044 440712383 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227512 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(=O)N\N=C\c1ccc(cc1)[N+]([O-])=O InChI=1S/C20H21N5O6S/c1-12-7-17(8-13(2)19(12)32(21,30)31)24-11-15(9-18(24)26)20(27)23-22-10-14-3-5-16(6-4-14)25(28)29/h3-8,10,15H,9,11H2,1-2H3,(H,23,27)(H2,21,30,31)/b22-10+ YFQTYSFYANGBFX-LSHDLFTRSA-N 50503776 CHEMBL4560953 Carbonic anhydrase 4 Homo sapiens 4700 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503776&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155558412 440712361 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51227514 Cc1cc(c(C)cc1N1CC(CC1=O)C(=O)N\N=C\c1ccccc1)S(N)(=O)=O InChI=1S/C20H22N4O4S/c1-13-9-18(29(21,27)28)14(2)8-17(13)24-12-16(10-19(24)25)20(26)23-22-11-15-6-4-3-5-7-15/h3-9,11,16H,10,12H2,1-2H3,(H,23,26)(H2,21,27,28)/b22-11+ UHOITOKAAASPAH-SSDVNMTOSA-N 50503804 CHEMBL4444784 Carbonic anhydrase 4 Homo sapiens 7600 ChEMBL 10.1016/j.bmc.2018.12.011 10.7270/Q25M68ZH 30553625 Vaškevičienė, I; Paketurytė, V; Pajanok, N; Žukauskas, Š; Sapijanskaitė, B; Kantminienė, K; Mickevičius, V; Zubrienė, A; Matulis, D Kaunas University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503804&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155517449 440712389 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223154 OB1OCc2ccc(NC(=O)\C=C\C(=O)Nc3ccc4COB(O)c4c3)cc12 InChI=1S/C18H16B2N2O6/c23-17(21-13-3-1-11-9-27-19(25)15(11)7-13)5-6-18(24)22-14-4-2-12-10-28-20(26)16(12)8-14/h1-8,25-26H,9-10H2,(H,21,23)(H,22,24)/b6-5+ LCQUPALTHKTJNI-AATRIKPKSA-N 50502608 CHEMBL4520305 Carbonic anhydrase 4 Homo sapiens 19800 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502608&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155541945 440711193 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223163 CC(C)(C)OC(=O)N[C@@H](CC(=O)Nc1ccc2COB(O)c2c1)C(=O)Nc1ccc2COB(O)c2c1 InChI=1S/C23H27B2N3O8/c1-23(2,3)36-22(31)28-19(21(30)27-16-7-5-14-12-35-25(33)18(14)9-16)10-20(29)26-15-6-4-13-11-34-24(32)17(13)8-15/h4-9,19,32-33H,10-12H2,1-3H3,(H,26,29)(H,27,30)(H,28,31)/t19-/m0/s1 RMQDZBWHFFNTJD-IBGZPJMESA-N 50502606 CHEMBL4539159 Carbonic anhydrase 4 Homo sapiens 35600 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502606&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155549723 440711191 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223171 OB1OCc2ccc(NC(=O)CCCCC(=O)Nc3ccc4COB(O)c4c3)cc12 InChI=1S/C20H22B2N2O6/c25-19(23-15-7-5-13-11-29-21(27)17(13)9-15)3-1-2-4-20(26)24-16-8-6-14-12-30-22(28)18(14)10-16/h5-10,27-28H,1-4,11-12H2,(H,23,25)(H,24,26) ZCLVXCKBENBHGU-UHFFFAOYSA-N 50502607 CHEMBL4530524 Carbonic anhydrase 4 Homo sapiens 3444 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502607&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155545916 440711192 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223172 OB1OCc2ccc(NC(=O)c3cc(cc(c3)C(=O)Nc3ccc4COB(O)c4c3)C(=O)Nc3ccc4COB(O)c4c3)cc12 InChI=1S/C30H24B3N3O9/c37-28(34-22-4-1-16-13-43-31(40)25(16)10-22)19-7-20(29(38)35-23-5-2-17-14-44-32(41)26(17)11-23)9-21(8-19)30(39)36-24-6-3-18-15-45-33(42)27(18)12-24/h1-12,40-42H,13-15H2,(H,34,37)(H,35,38)(H,36,39) PZIRPPZPPHKRAJ-UHFFFAOYSA-N 50502611 CHEMBL4532459 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502611&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155546892 440711196 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51223179 OB1OCc2ccc(NC(=O)\C=C\C=C\C(=O)Nc3ccc4COB(O)c4c3)cc12 InChI=1S/C20H18B2N2O6/c25-19(23-15-7-5-13-11-29-21(27)17(13)9-15)3-1-2-4-20(26)24-16-8-6-14-12-30-22(28)18(14)10-16/h1-10,27-28H,11-12H2,(H,23,25)(H,24,26)/b3-1+,4-2+ HJXUJENNGOAAKE-ZPUQHVIOSA-N 50502610 CHEMBL4466186 Carbonic anhydrase 4 Homo sapiens 58300 ChEMBL 10.1021/acsmedchemlett.9b00252 10.7270/Q21C2137 31413806 Larcher, A; Nocentini, A; Supuran, CT; Winum, JY; van der Lee, A; Vasseur, JJ; Laurencin, D; Smietana, M Universit£ de Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502610&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155531537 440711195 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51323145 [Ag+].Nc1cc(cc(c1O)[N+]([O-])=O)S(=O)(=O)[N-][N+]([O-])=O InChI=1S/C6H5N4O7S.Ag/c7-4-1-3(18(16,17)8-10(14)15)2-5(6(4)11)9(12)13;/h1-2,11H,7H2;/q-1;+1 DQIAIQBAUCKBTK-UHFFFAOYSA-N 50535389 CHEMBL4545611 Carbonic anhydrase 4 Homo sapiens 1900 ChEMBL 10.1021/acsmedchemlett.8b00430 10.7270/Q2RX9GKK 30996772 Bonardi, A; Vermelho, AB; da Silva Cardoso, V; de Souza Pereira, MC; da Silva Lara, L; Selleri, S; Gratteri, P; Supuran, CT; Nocentini, A University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535389&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155552773 440743971 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51323151 [Ag+].CN(C)c1ccccc1S(=O)(=O)[N-][N+]([O-])=O InChI=1S/C8H10N3O4S.Ag/c1-10(2)7-5-3-4-6-8(7)16(14,15)9-11(12)13;/h3-6H,1-2H3;/q-1;+1 HWMZZXOOJXBQQC-UHFFFAOYSA-N 50535394 CHEMBL4544253 Carbonic anhydrase 4 Homo sapiens 32200 ChEMBL 10.1021/acsmedchemlett.8b00430 10.7270/Q2RX9GKK 30996772 Bonardi, A; Vermelho, AB; da Silva Cardoso, V; de Souza Pereira, MC; da Silva Lara, L; Selleri, S; Gratteri, P; Supuran, CT; Nocentini, A University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535394&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155552316 440743976 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51323164 [Ag+].Nc1ccccc1S(=O)(=O)[N-][N+]([O-])=O InChI=1S/C6H6N3O4S.Ag/c7-5-3-1-2-4-6(5)14(12,13)8-9(10)11;/h1-4H,7H2;/q-1;+1 HCZODDJYFZZYSE-UHFFFAOYSA-N 50535392 CHEMBL4436477 Carbonic anhydrase 4 Homo sapiens 39200 ChEMBL 10.1021/acsmedchemlett.8b00430 10.7270/Q2RX9GKK 30996772 Bonardi, A; Vermelho, AB; da Silva Cardoso, V; de Souza Pereira, MC; da Silva Lara, L; Selleri, S; Gratteri, P; Supuran, CT; Nocentini, A University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535392&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155511800 440743974 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51323165 [Ag+].Nc1cccc(c1)S(=O)(=O)[N-][N+]([O-])=O InChI=1S/C6H6N3O4S.Ag/c7-5-2-1-3-6(4-5)14(12,13)8-9(10)11;/h1-4H,7H2;/q-1;+1 KSIQFYQTAYFXEJ-UHFFFAOYSA-N 50535391 CHEMBL4476550 Carbonic anhydrase 4 Homo sapiens 4300 ChEMBL 10.1021/acsmedchemlett.8b00430 10.7270/Q2RX9GKK 30996772 Bonardi, A; Vermelho, AB; da Silva Cardoso, V; de Souza Pereira, MC; da Silva Lara, L; Selleri, S; Gratteri, P; Supuran, CT; Nocentini, A University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535391&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155538289 440743973 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51323166 [Ag+].Nc1ccc(cc1)S(=O)(=O)[N-][N+]([O-])=O InChI=1S/C6H6N3O4S.Ag/c7-5-1-3-6(4-2-5)14(12,13)8-9(10)11;/h1-4H,7H2;/q-1;+1 BRKMLLKMUBLMKQ-UHFFFAOYSA-N 50535395 CHEMBL4562842 Carbonic anhydrase 4 Homo sapiens 23600 ChEMBL 10.1021/acsmedchemlett.8b00430 10.7270/Q2RX9GKK 30996772 Bonardi, A; Vermelho, AB; da Silva Cardoso, V; de Souza Pereira, MC; da Silva Lara, L; Selleri, S; Gratteri, P; Supuran, CT; Nocentini, A University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535395&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155560101 440743977 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51323167 [Ag+].CN(C)c1ccc(cc1)S(=O)(=O)[N-][N+]([O-])=O InChI=1S/C8H10N3O4S.Ag/c1-10(2)7-3-5-8(6-4-7)16(14,15)9-11(12)13;/h3-6H,1-2H3;/q-1;+1 KPCLWOKOBJEQIM-UHFFFAOYSA-N 50535397 CHEMBL4439864 Carbonic anhydrase 4 Homo sapiens 11000 ChEMBL 10.1021/acsmedchemlett.8b00430 10.7270/Q2RX9GKK 30996772 Bonardi, A; Vermelho, AB; da Silva Cardoso, V; de Souza Pereira, MC; da Silva Lara, L; Selleri, S; Gratteri, P; Supuran, CT; Nocentini, A University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535397&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155514131 440743979 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51323168 [Ag+].NCc1ccc(cc1)S(=O)(=O)[N-][N+]([O-])=O InChI=1S/C7H8N3O4S.Ag/c8-5-6-1-3-7(4-2-6)15(13,14)9-10(11)12;/h1-4H,5,8H2;/q-1;+1 XYLRQUQSEDKMOO-UHFFFAOYSA-N 50535390 CHEMBL4558023 Carbonic anhydrase 4 Homo sapiens 3100 ChEMBL 10.1021/acsmedchemlett.8b00430 10.7270/Q2RX9GKK 30996772 Bonardi, A; Vermelho, AB; da Silva Cardoso, V; de Souza Pereira, MC; da Silva Lara, L; Selleri, S; Gratteri, P; Supuran, CT; Nocentini, A University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535390&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155554763 440743972 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51323169 [Ag+].Cn1nc(sc1=N)S(=O)(=O)[N-][N+]([O-])=O InChI=1S/C3H4N5O4S2.Ag/c1-7-2(4)13-3(5-7)14(11,12)6-8(9)10;/h4H,1H3;/q-1;+1 MILNOBHZQYKDKC-UHFFFAOYSA-N 50535388 CHEMBL4594101 Carbonic anhydrase 4 Homo sapiens 4800 ChEMBL 10.1021/acsmedchemlett.8b00430 10.7270/Q2RX9GKK 30996772 Bonardi, A; Vermelho, AB; da Silva Cardoso, V; de Souza Pereira, MC; da Silva Lara, L; Selleri, S; Gratteri, P; Supuran, CT; Nocentini, A University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535388&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155569555 440743970 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51323186 [Ag+].CN(C)c1cccc(c1)S(=O)(=O)[N-][N+]([O-])=O InChI=1S/C8H10N3O4S.Ag/c1-10(2)7-4-3-5-8(6-7)16(14,15)9-11(12)13;/h3-6H,1-2H3;/q-1;+1 LKIRSIZUAYGAIM-UHFFFAOYSA-N 50535393 CHEMBL4443515 Carbonic anhydrase 4 Homo sapiens 4500 ChEMBL 10.1021/acsmedchemlett.8b00430 10.7270/Q2RX9GKK 30996772 Bonardi, A; Vermelho, AB; da Silva Cardoso, V; de Souza Pereira, MC; da Silva Lara, L; Selleri, S; Gratteri, P; Supuran, CT; Nocentini, A University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535393&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155516553 440743975 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51323187 [Ag+].Nc1nnc(s1)S(=O)(=O)[N-][N+]([O-])=O InChI=1S/C2H2N5O4S2.Ag/c3-1-4-5-2(12-1)13(10,11)6-7(8)9;/h(H2,3,4);/q-1;+1 WUQAJXOHTPOSHT-UHFFFAOYSA-N 50535396 CHEMBL4580887 Carbonic anhydrase 4 Homo sapiens 1400 ChEMBL 10.1021/acsmedchemlett.8b00430 10.7270/Q2RX9GKK 30996772 Bonardi, A; Vermelho, AB; da Silva Cardoso, V; de Souza Pereira, MC; da Silva Lara, L; Selleri, S; Gratteri, P; Supuran, CT; Nocentini, A University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50535396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50535396&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155561198 440743978 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51323196 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 75 ChEMBL 10.1021/acsmedchemlett.8b00430 10.7270/Q2RX9GKK 30996772 Bonardi, A; Vermelho, AB; da Silva Cardoso, V; de Souza Pereira, MC; da Silva Lara, L; Selleri, S; Gratteri, P; Supuran, CT; Nocentini, A University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295697 CCCCCCCCCCCCSP(=O)(Oc1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C24H36NO4PS2/c1-2-3-4-5-6-7-8-9-10-14-21-31-30(26,23-15-12-11-13-16-23)29-22-17-19-24(20-18-22)32(25,27)28/h11-13,15-20H,2-10,14,21H2,1H3,(H2,25,27,28) FLKUIPIWTDVAMV-UHFFFAOYSA-N 50528163 CHEMBL4542558 Carbonic anhydrase 4 Homo sapiens 4164 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528163&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155551334 440736745 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295698 NS(=O)(=O)c1ccc(OP(=O)(Nc2ccccc2)c2ccccc2)cc1 InChI=1S/C18H17N2O4PS/c19-26(22,23)18-13-11-16(12-14-18)24-25(21,17-9-5-2-6-10-17)20-15-7-3-1-4-8-15/h1-14H,(H,20,21)(H2,19,22,23) KNDARAGEZKRGBF-UHFFFAOYSA-N 50528164 CHEMBL4453128 Carbonic anhydrase 4 Homo sapiens 860 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528164&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155523328 440736746 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295705 NS(=O)(=O)c1ccc(OP(O)(=O)c2ccccc2)cc1 InChI=1S/C12H12NO5PS/c13-20(16,17)12-8-6-10(7-9-12)18-19(14,15)11-4-2-1-3-5-11/h1-9H,(H,14,15)(H2,13,16,17) HADGOFIYAKWMTA-UHFFFAOYSA-N 50528168 CHEMBL4474178 Carbonic anhydrase 4 Homo sapiens 220 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528168&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search L8N 6SDS,6SDT 146160385 440736750 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295765 COP(=O)(Oc1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C13H14NO5PS/c1-18-20(15,12-5-3-2-4-6-12)19-11-7-9-13(10-8-11)21(14,16)17/h2-10H,1H3,(H2,14,16,17) LIEIKZRNGVBKGW-UHFFFAOYSA-N 50528173 CHEMBL4535205 Carbonic anhydrase 4 Homo sapiens 259 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528173&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155547526 440736755 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295766 CC(C)OP(=O)(Oc1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C15H18NO5PS/c1-12(2)20-22(17,14-6-4-3-5-7-14)21-13-8-10-15(11-9-13)23(16,18)19/h3-12H,1-2H3,(H2,16,18,19) PEQTVDTVQHQBMY-UHFFFAOYSA-N 50528167 CHEMBL4446462 Carbonic anhydrase 4 Homo sapiens 1196 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528167&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155518510 440736749 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295767 NS(=O)(=O)c1ccc(OP(=O)(OCC#C)c2ccccc2)cc1 InChI=1S/C15H14NO5PS/c1-2-12-20-22(17,14-6-4-3-5-7-14)21-13-8-10-15(11-9-13)23(16,18)19/h1,3-11H,12H2,(H2,16,18,19) QPPDZAQVRNMGGM-UHFFFAOYSA-N 50528170 CHEMBL4447288 Carbonic anhydrase 4 Homo sapiens 1322 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528170&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155519248 440736752 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295768 COCCOP(=O)(Oc1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C15H18NO6PS/c1-20-11-12-21-23(17,14-5-3-2-4-6-14)22-13-7-9-15(10-8-13)24(16,18)19/h2-10H,11-12H2,1H3,(H2,16,18,19) INIVRUBCRFFWDF-UHFFFAOYSA-N 50528161 CHEMBL4435066 Carbonic anhydrase 4 Homo sapiens 1644 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528161&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155511075 440736743 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295769 NS(=O)(=O)c1ccc(OP(=O)(SCc2ccccc2)c2ccccc2)cc1 InChI=1S/C19H18NO4PS2/c20-27(22,23)19-13-11-17(12-14-19)24-25(21,18-9-5-2-6-10-18)26-15-16-7-3-1-4-8-16/h1-14H,15H2,(H2,20,22,23) XMTKUTDIBADOTR-UHFFFAOYSA-N 50528174 CHEMBL4515265 Carbonic anhydrase 4 Homo sapiens 4456 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528174&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155539783 440736756 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295770 NS(=O)(=O)c1ccc(OP(=O)(Sc2ccccc2)c2ccccc2)cc1 InChI=1S/C18H16NO4PS2/c19-26(21,22)18-13-11-15(12-14-18)23-24(20,16-7-3-1-4-8-16)25-17-9-5-2-6-10-17/h1-14H,(H2,19,21,22) KTMXZVZXSJIZEX-UHFFFAOYSA-N 50528160 CHEMBL4537722 Carbonic anhydrase 4 Homo sapiens 2633 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528160&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155548326 440736742 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295771 CCCNP(=O)(Oc1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C15H19N2O4PS/c1-2-12-17-22(18,14-6-4-3-5-7-14)21-13-8-10-15(11-9-13)23(16,19)20/h3-11H,2,12H2,1H3,(H,17,18)(H2,16,19,20) XBRYFYVWFPOYAA-UHFFFAOYSA-N 50528162 CHEMBL4476108 Carbonic anhydrase 4 Homo sapiens 1516 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528162&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155538224 440736744 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295772 NS(=O)(=O)c1ccc(OP(=O)(N2CCCC2)c2ccccc2)cc1 InChI=1S/C16H19N2O4PS/c17-24(20,21)16-10-8-14(9-11-16)22-23(19,18-12-4-5-13-18)15-6-2-1-3-7-15/h1-3,6-11H,4-5,12-13H2,(H2,17,20,21) HQPKNVJWNKZNBY-UHFFFAOYSA-N 50528172 CHEMBL4465406 Carbonic anhydrase 4 Homo sapiens 308 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528172&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155531382 440736754 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295773 NS(=O)(=O)c1ccc(OP(=O)(N2CCOCC2)c2ccccc2)cc1 InChI=1S/C16H19N2O5PS/c17-25(20,21)16-8-6-14(7-9-16)23-24(19,15-4-2-1-3-5-15)18-10-12-22-13-11-18/h1-9H,10-13H2,(H2,17,20,21) RCZQUWVJXLDDCT-UHFFFAOYSA-N 50528156 CHEMBL4582056 Carbonic anhydrase 4 Homo sapiens 120 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528156&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155554179 440736738 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295774 NS(=O)(=O)c1ccc(OP(=O)(NCc2ccccc2)c2ccccc2)cc1 InChI=1S/C19H19N2O4PS/c20-27(23,24)19-13-11-17(12-14-19)25-26(22,18-9-5-2-6-10-18)21-15-16-7-3-1-4-8-16/h1-14H,15H2,(H,21,22)(H2,20,23,24) CCVHSBIZPZQCRR-UHFFFAOYSA-N 50528177 CHEMBL4449772 Carbonic anhydrase 4 Homo sapiens 644 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528177&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155521041 440736759 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295775 NS(=O)(=O)c1ccc(O[P@](=O)(OCC#C)c2ccccc2)cc1 InChI=1S/C15H14NO5PS/c1-2-12-20-22(17,14-6-4-3-5-7-14)21-13-8-10-15(11-9-13)23(16,18)19/h1,3-11H,12H2,(H2,16,18,19)/t22-/m1/s1 QPPDZAQVRNMGGM-JOCHJYFZSA-N 50528175 CHEMBL4464493 Carbonic anhydrase 4 Homo sapiens 1984 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528175&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155530358 440736757 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295805 NS(=O)(=O)c1ccc(OP(=O)(Oc2ccccc2)c2ccccc2)cc1 InChI=1S/C18H16NO5PS/c19-26(21,22)18-13-11-16(12-14-18)24-25(20,17-9-5-2-6-10-17)23-15-7-3-1-4-8-15/h1-14H,(H2,19,21,22) NHZKQUURXQFXIN-UHFFFAOYSA-N 50528176 CHEMBL4446061 Carbonic anhydrase 4 Homo sapiens 2619 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528176&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155518220 440736758 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295806 CCN(CC)P(=O)(Oc1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C16H21N2O4PS/c1-3-18(4-2)23(19,15-8-6-5-7-9-15)22-14-10-12-16(13-11-14)24(17,20)21/h5-13H,3-4H2,1-2H3,(H2,17,20,21) CUPWFRGLWZHRST-UHFFFAOYSA-N 50528171 CHEMBL4516808 Carbonic anhydrase 4 Homo sapiens 371 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528171&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155540401 440736753 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295807 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295837 CCOP(=O)(Oc1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C14H16NO5PS/c1-2-19-21(16,13-6-4-3-5-7-13)20-12-8-10-14(11-9-12)22(15,17)18/h3-11H,2H2,1H3,(H2,15,17,18) SKWKPUDZFINNSN-UHFFFAOYSA-N 50528157 CHEMBL4524421 Carbonic anhydrase 4 Homo sapiens 425 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528157&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155520019 440736739 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295838 NS(=O)(=O)c1ccc(OP(=O)(Oc2ccc(cc2)S(N)(=O)=O)c2ccccc2)cc1 InChI=1S/C18H17N2O7PS2/c19-29(22,23)17-10-6-14(7-11-17)26-28(21,16-4-2-1-3-5-16)27-15-8-12-18(13-9-15)30(20,24)25/h1-13H,(H2,19,22,23)(H2,20,24,25) IADLCVBIHKTGOW-UHFFFAOYSA-N 50528169 CHEMBL4579472 Carbonic anhydrase 4 Homo sapiens 360 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528169&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155565419 440736751 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295839 NP(=O)(Oc1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C12H13N2O4PS/c13-19(15,11-4-2-1-3-5-11)18-10-6-8-12(9-7-10)20(14,16)17/h1-9H,(H2,13,15)(H2,14,16,17) JYQGMEIZPFBRJR-UHFFFAOYSA-N 50528165 CHEMBL4543084 Carbonic anhydrase 4 Homo sapiens 292 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528165&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155551784 440736747 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295840 CN1CCN(CC1)P(=O)(Oc1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C17H22N3O4PS/c1-19-11-13-20(14-12-19)25(21,16-5-3-2-4-6-16)24-15-7-9-17(10-8-15)26(18,22)23/h2-10H,11-14H2,1H3,(H2,18,22,23) IVUJWXBHGNCGLZ-UHFFFAOYSA-N 50528159 CHEMBL4549267 Carbonic anhydrase 4 Homo sapiens 77 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528159&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155550616 440736741 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295859 CCSP(=O)(Oc1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C14H16NO4PS2/c1-2-21-20(16,13-6-4-3-5-7-13)19-12-8-10-14(11-9-12)22(15,17)18/h3-11H,2H2,1H3,(H2,15,17,18) DPWUIFSNYYMDBQ-UHFFFAOYSA-N 50528158 CHEMBL4447629 Carbonic anhydrase 4 Homo sapiens 1389 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528158&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155519288 440736740 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51295860 NS(=O)(=O)c1ccc(O[P@@](=O)(OCC#C)c2ccccc2)cc1 InChI=1S/C15H14NO5PS/c1-2-12-20-22(17,14-6-4-3-5-7-14)21-13-8-10-15(11-9-13)23(16,18)19/h1,3-11H,12H2,(H2,16,18,19)/t22-/m0/s1 QPPDZAQVRNMGGM-QFIPXVFZSA-N 50528166 CHEMBL4519039 Carbonic anhydrase 4 Homo sapiens 747 ChEMBL 10.1021/acs.jmedchem.9b02135 10.7270/Q2W380S2 32364386 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528166&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155541807 440736748 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293167 CC(=O)C(=N/Nc1ccc(Br)cc1)\C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C16H15BrN4O4S/c1-10(22)15(21-20-13-4-2-11(17)3-5-13)16(23)19-12-6-8-14(9-7-12)26(18,24)25/h2-9,20H,1H3,(H,19,23)(H2,18,24,25)/b21-15+ LZVGOAHQURMYHV-RCCKNPSSSA-N 50527079 CHEMBL4472481 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527079&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155535598 440735661 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293168 COc1ccc(N\N=C(/Cl)C(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C15H15ClN4O4S/c1-24-12-6-2-11(3-7-12)19-20-14(16)15(21)18-10-4-8-13(9-5-10)25(17,22)23/h2-9,19H,1H3,(H,18,21)(H2,17,22,23)/b20-14- MTFFDEQFKGDXLJ-ZHZULCJRSA-N 50527080 CHEMBL4460385 Carbonic anhydrase 4 Homo sapiens 6416 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527080&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155527673 440735662 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293171 CC(=O)C(=C/c1ccccc1)\C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C17H16N2O4S/c1-12(20)16(11-13-5-3-2-4-6-13)17(21)19-14-7-9-15(10-8-14)24(18,22)23/h2-11H,1H3,(H,19,21)(H2,18,22,23)/b16-11+ NDDZSPLPKNIELX-LFIBNONCSA-N 50527082 CHEMBL4447914 Carbonic anhydrase 4 Homo sapiens 958 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527082&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155519627 440735664 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293201 CC(=O)C(=C/c1ccc(Cl)cc1)\C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C17H15ClN2O4S/c1-11(21)16(10-12-2-4-13(18)5-3-12)17(22)20-14-6-8-15(9-7-14)25(19,23)24/h2-10H,1H3,(H,20,22)(H2,19,23,24)/b16-10+ GQEQFIWWXCJNPT-MHWRWJLKSA-N 50527086 CHEMBL4458973 Carbonic anhydrase 4 Homo sapiens 145 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527086&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155527145 440735668 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293202 CC(=O)C(=C/c1cccc(c1)[N+]([O-])=O)\C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C17H15N3O6S/c1-11(21)16(10-12-3-2-4-14(9-12)20(23)24)17(22)19-13-5-7-15(8-6-13)27(18,25)26/h2-10H,1H3,(H,19,22)(H2,18,25,26)/b16-10+ OKVFYCSQWCMGLT-MHWRWJLKSA-N 50527083 CHEMBL4557855 Carbonic anhydrase 4 Homo sapiens 387 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527083&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155554800 440735665 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293203 CC(=O)C(=C/c1cccs1)\C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C15H14N2O4S2/c1-10(18)14(9-12-3-2-8-22-12)15(19)17-11-4-6-13(7-5-11)23(16,20)21/h2-9H,1H3,(H,17,19)(H2,16,20,21)/b14-9+ YMJYNNBBJGHAJE-NTEUORMPSA-N 50527077 CHEMBL4455089 Carbonic anhydrase 4 Homo sapiens 810 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527077&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155524915 440735659 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293204 CC(=O)C(=N/Nc1ccccc1)\C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C16H16N4O4S/c1-11(21)15(20-19-13-5-3-2-4-6-13)16(22)18-12-7-9-14(10-8-12)25(17,23)24/h2-10,19H,1H3,(H,18,22)(H2,17,23,24)/b20-15+ AJPBXAOWMZHGEB-HMMYKYKNSA-N 50527088 CHEMBL4525908 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527088&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155543271 440735670 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293205 CC(=O)C(=N/Nc1ccc(F)cc1)\C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C16H15FN4O4S/c1-10(22)15(21-20-13-4-2-11(17)3-5-13)16(23)19-12-6-8-14(9-7-12)26(18,24)25/h2-9,20H,1H3,(H,19,23)(H2,18,24,25)/b21-15+ QQVDFMQGDWONCM-RCCKNPSSSA-N 50527089 CHEMBL4590738 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527089&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155568447 440735671 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293206 CC(=O)C(=N/Nc1ccc(cc1)C#N)\C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C17H15N5O4S/c1-11(23)16(22-21-14-4-2-12(10-18)3-5-14)17(24)20-13-6-8-15(9-7-13)27(19,25)26/h2-9,21H,1H3,(H,20,24)(H2,19,25,26)/b22-16+ OBVZANDGCZVGPS-CJLVFECKSA-N 50527097 CHEMBL4572753 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527097&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155563215 440735679 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293207 CC(=O)C(=N/Nc1cccc(c1)[N+]([O-])=O)\C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C16H15N5O6S/c1-10(22)15(20-19-12-3-2-4-13(9-12)21(24)25)16(23)18-11-5-7-14(8-6-11)28(17,26)27/h2-9,19H,1H3,(H,18,23)(H2,17,26,27)/b20-15+ IFTMMSBZECZPRT-HMMYKYKNSA-N 50527081 CHEMBL4449372 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527081&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155520806 440735663 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293208 NS(=O)(=O)c1ccc(NC(=O)C(\Cl)=N\Nc2ccc(F)cc2)cc1 InChI=1S/C14H12ClFN4O3S/c15-13(20-19-11-3-1-9(16)2-4-11)14(21)18-10-5-7-12(8-6-10)24(17,22)23/h1-8,19H,(H,18,21)(H2,17,22,23)/b20-13- AJLMUGVHFFKXAC-MOSHPQCFSA-N 50527093 CHEMBL4520993 Carbonic anhydrase 4 Homo sapiens 7380 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527093&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155542555 440735675 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293209 NS(=O)(=O)c1ccc(NC(=O)C(\Cl)=N\Nc2ccc(Cl)cc2)cc1 InChI=1S/C14H12Cl2N4O3S/c15-9-1-3-11(4-2-9)19-20-13(16)14(21)18-10-5-7-12(8-6-10)24(17,22)23/h1-8,19H,(H,18,21)(H2,17,22,23)/b20-13- WOTQNSVSISRUJF-MOSHPQCFSA-N 50527094 CHEMBL4577572 Carbonic anhydrase 4 Homo sapiens 907 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527094&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155565149 440735676 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293210 NS(=O)(=O)c1ccc(NC(=O)C(\Cl)=N\Nc2ccc(Br)cc2)cc1 InChI=1S/C14H12BrClN4O3S/c15-9-1-3-11(4-2-9)19-20-13(16)14(21)18-10-5-7-12(8-6-10)24(17,22)23/h1-8,19H,(H,18,21)(H2,17,22,23)/b20-13- JYVZUYYLYBNOMS-MOSHPQCFSA-N 50527095 CHEMBL4521522 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527095&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155542660 440735677 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293211 CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1 HCRKCZRJWPKOAR-JTQLQIEISA-N 10885 (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::(R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-E)-1,2-thiazine-6-sulfonamide 1,1-dioxide::AL-4862::Azopt::Brinzolamide (BRZ)::brinzolamide Carbonic anhydrase 4 Homo sapiens 3950 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10885&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search BZ1 3ZNC,4M2V,4M2R,6BBS 68844 46511455 3176 DB01194 6797 C07760 ZINC03953037 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293239 CC(=O)CC(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C10H12N2O4S/c1-7(13)6-10(14)12-8-2-4-9(5-3-8)17(11,15)16/h2-5H,6H2,1H3,(H,12,14)(H2,11,15,16) FDZMNCCKUUOJEX-UHFFFAOYSA-N 50527085 CHEMBL4568951 Carbonic anhydrase 4 Homo sapiens 885 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527085&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 78297 440735667 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293240 CC(=O)C(=C/c1ccc(F)cc1Cl)\C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C17H14ClFN2O4S/c1-10(22)15(8-11-2-3-12(19)9-16(11)18)17(23)21-13-4-6-14(7-5-13)26(20,24)25/h2-9H,1H3,(H,21,23)(H2,20,24,25)/b15-8+ XOFJOGPCIQVDEZ-OVCLIPMQSA-N 50527084 CHEMBL4451455 Carbonic anhydrase 4 Homo sapiens 223 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527084&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155521830 440735666 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293241 CC(=O)C(=N/Nc1ccc(Cl)cc1)\C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C16H15ClN4O4S/c1-10(22)15(21-20-13-4-2-11(17)3-5-13)16(23)19-12-6-8-14(9-7-12)26(18,24)25/h2-9,20H,1H3,(H,19,23)(H2,18,24,25)/b21-15+ YQYPJWHEQVOQDW-RCCKNPSSSA-N 50527090 CHEMBL4483065 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527090&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155539730 440735672 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293242 COc1ccc(N\N=C(/C(C)=O)C(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1OC InChI=1S/C18H20N4O6S/c1-11(23)17(22-21-13-6-9-15(27-2)16(10-13)28-3)18(24)20-12-4-7-14(8-5-12)29(19,25)26/h4-10,21H,1-3H3,(H,20,24)(H2,19,25,26)/b22-17+ ILMMSCUFGYFLBL-OQKWZONESA-N 50527092 CHEMBL4593779 Carbonic anhydrase 4 Homo sapiens 1477 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527092&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155569676 440735674 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293243 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 IAVUPMFITXYVAF-XPUUQOCRSA-N 10884 (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide::Dorzolamide (DRZ)::Dorzolamide (DZA) Carbonic anhydrase 4 Homo sapiens 8500 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10884&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ETS 4M2W,4M2U,4K13,3FW3,6BC9,1CIL 5284549 46511454 4702 DB00869 6810 C06969 ZINC01530621 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293245 COc1ccc(N\N=C(/C(C)=O)C(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C17H18N4O5S/c1-11(22)16(21-20-13-3-7-14(26-2)8-4-13)17(23)19-12-5-9-15(10-6-12)27(18,24)25/h3-10,20H,1-2H3,(H,19,23)(H2,18,24,25)/b21-16+ LLZAZOAKDPBUKT-LTGZKZEYSA-N 50527091 CHEMBL4439983 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527091&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155514230 440735673 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293246 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293249 COc1ccc(\C=C(/C(C)=O)C(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C18H18N2O5S/c1-12(21)17(11-13-3-7-15(25-2)8-4-13)18(22)20-14-5-9-16(10-6-14)26(19,23)24/h3-11H,1-2H3,(H,20,22)(H2,19,23,24)/b17-11+ BNJYMFAWZKZPKJ-GZTJUZNOSA-N 50527087 CHEMBL4450169 Carbonic anhydrase 4 Homo sapiens 609 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527087&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155521462 440735669 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293254 CC(=O)C(=C/c1ccccc1Cl)\C(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C17H15ClN2O4S/c1-11(21)15(10-12-4-2-3-5-16(12)18)17(22)20-13-6-8-14(9-7-13)25(19,23)24/h2-10H,1H3,(H,20,22)(H2,19,23,24)/b15-10+ JJUIDVDVQGZFGE-XNTDXEJSSA-N 50527096 CHEMBL4558452 Carbonic anhydrase 4 Homo sapiens 383 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527096&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155557452 440735678 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51293255 NS(=O)(=O)c1ccc(NC(=O)C(\Cl)=N\Nc2ccccc2)cc1 InChI=1S/C14H13ClN4O3S/c15-13(19-18-11-4-2-1-3-5-11)14(20)17-10-6-8-12(9-7-10)23(16,21)22/h1-9,18H,(H,17,20)(H2,16,21,22)/b19-13- GPSWNOYIICWKDE-UYRXBGFRSA-N 50527078 CHEMBL4461719 Carbonic anhydrase 4 Homo sapiens 7364 ChEMBL 10.1021/acs.jmedchem.9b02090 10.7270/Q25Q50JG 32031797 Fares, M; Eldehna, WM; Bua, S; Lanzi, C; Lucarini, L; Masini, E; Peat, TS; Abdel-Aziz, HA; Nocentini, A; Keller, PA; Supuran, CT University of Wollongong http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527078&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155528605 440735660 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51288973 COc1cc(\C=C2\SC(Nc3ccc(OS(N)(=O)=O)cc3)=NC2=O)cc(OC)c1OC InChI=1S/C19H19N3O7S2/c1-26-14-8-11(9-15(27-2)17(14)28-3)10-16-18(23)22-19(30-16)21-12-4-6-13(7-5-12)29-31(20,24)25/h4-10H,1-3H3,(H2,20,24,25)(H,21,22,23)/b16-10+ WWOUYKDYLNVBGB-MHWRWJLKSA-N 50525477 CHEMBL4554643 Carbonic anhydrase 4 Homo sapiens 42 ChEMBL 10.1016/j.ejmech.2019.06.052 10.7270/Q2B27ZQ2 31255926 Zaraei, SO; Abduelkarem, AR; Anbar, HS; Kobeissi, S; Mohammad, M; Ossama, A; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525477&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155556147 440734059 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51288980 NS(=O)(=O)Oc1ccc(NC2=NC(=O)\C(S2)=C/c2ccccc2)cc1 InChI=1S/C16H13N3O4S2/c17-25(21,22)23-13-8-6-12(7-9-13)18-16-19-15(20)14(24-16)10-11-4-2-1-3-5-11/h1-10H,(H2,17,21,22)(H,18,19,20)/b14-10+ QXXNOQFTGLIZJJ-GXDHUFHOSA-N 50525474 CHEMBL4457432 Carbonic anhydrase 4 Homo sapiens 76 ChEMBL 10.1016/j.ejmech.2019.06.052 10.7270/Q2B27ZQ2 31255926 Zaraei, SO; Abduelkarem, AR; Anbar, HS; Kobeissi, S; Mohammad, M; Ossama, A; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525474&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155525961 440734056 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51335744 CC1(C)O[C@@H]2CN(CCCCCCn3cc(CNc4ccc(cc4)S(N)(=O)=O)nn3)C[C@@H](O)[C@@H]2O1 InChI=1S/C23H36N6O5S/c1-23(2)33-21-16-28(15-20(30)22(21)34-23)11-5-3-4-6-12-29-14-18(26-27-29)13-25-17-7-9-19(10-8-17)35(24,31)32/h7-10,14,20-22,25,30H,3-6,11-13,15-16H2,1-2H3,(H2,24,31,32)/t20-,21-,22+/m1/s1 PNQLYJMCGFDUPZ-VSKRKVRLSA-N 50540616 CHEMBL4643051 Carbonic anhydrase 4 Homo sapiens 81 ChEMBL 10.1021/acsmedchemlett.9b00590 10.7270/Q2B27ZTD 32435377 Pratesi, D; Matassini, C; Goti, A; Angeli, A; Carta, F; Supuran, CT; Spanevello, R; Cardona, F Universit£ di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540616&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156017154 442142179 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51335754 CC1(C)O[C@@H]2CN(CCCCCCn3cc(CNc4ccc(cc4)S(N)(=O)=O)nn3)[C@H]([C@@H](O)[C@@H]2O1)[C@@H]1[C@H](O)[C@H]2CO[C@@H](O2)[C@H]1O InChI=1S/C29H44N6O9S/c1-29(2)43-20-15-34(23(26(38)27(20)44-29)22-24(36)21-16-41-28(42-21)25(22)37)11-5-3-4-6-12-35-14-18(32-33-35)13-31-17-7-9-19(10-8-17)45(30,39)40/h7-10,14,20-28,31,36-38H,3-6,11-13,15-16H2,1-2H3,(H2,30,39,40)/t20-,21?,22-,23+,24-,25+,26-,27-,28?/m1/s1 MWZLBQWPJOSIAH-MAEDULGDSA-N 50540617 CHEMBL4649348 Carbonic anhydrase 4 Homo sapiens 659 ChEMBL 10.1021/acsmedchemlett.9b00590 10.7270/Q2B27ZTD 32435377 Pratesi, D; Matassini, C; Goti, A; Angeli, A; Carta, F; Supuran, CT; Spanevello, R; Cardona, F Universit£ di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540617&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156021919 442142180 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51335764 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acsmedchemlett.9b00590 10.7270/Q2B27ZTD 32435377 Pratesi, D; Matassini, C; Goti, A; Angeli, A; Carta, F; Supuran, CT; Spanevello, R; Cardona, F Universit£ di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 50004067 COc1ccc(cc1)C1=NN(C(C1)c1ccc(OS(N)(=O)=O)cc1)C(C)=O InChI=1S/C18H19N3O5S/c1-12(22)21-18(14-5-9-16(10-6-14)26-27(19,23)24)11-17(20-21)13-3-7-15(25-2)8-4-13/h3-10,18H,11H2,1-2H3,(H2,19,23,24) RHGAKHPDMOCLCI-UHFFFAOYSA-N 50515806 CHEMBL4533252 Carbonic anhydrase 4 Homo sapiens 21 ChEMBL 10.1016/j.ejmech.2018.11.017 10.7270/Q21839DX 30496988 Zhao, C; Rakesh, KP; Ravidar, L; Fang, WY; Qin, HL Wuhan University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515806&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155547275 440724388 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336451 NS(=O)(=O)c1ccc(CCNCc2ccccc2)cc1 InChI=1S/C15H18N2O2S/c16-20(18,19)15-8-6-13(7-9-15)10-11-17-12-14-4-2-1-3-5-14/h1-9,17H,10-12H2,(H2,16,18,19) KGBDEGOVGMMQDX-UHFFFAOYSA-N 50013771 CHEMBL3264980 Carbonic anhydrase 4 Homo sapiens 2854 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013771&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4718084 103925805 CHEMBL3264980 ZINC96178908 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336452 NS(=O)(=O)c1ccc(CCNCc2ccc(cc2)[N+]([O-])=O)cc1 InChI=1S/C15H17N3O4S/c16-23(21,22)15-7-3-12(4-8-15)9-10-17-11-13-1-5-14(6-2-13)18(19)20/h1-8,17H,9-11H2,(H2,16,21,22) JMHICGAEAVPXNK-UHFFFAOYSA-N 50540914 CHEMBL4649189 Carbonic anhydrase 4 Homo sapiens 1685 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540914&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4718991 442142477 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336453 NS(=O)(=O)c1ccc(CCNCc2ccc(F)cc2)cc1 InChI=1S/C15H17FN2O2S/c16-14-5-1-13(2-6-14)11-18-10-9-12-3-7-15(8-4-12)21(17,19)20/h1-8,18H,9-11H2,(H2,17,19,20) YMDDQZJGDFEYMH-UHFFFAOYSA-N 50540915 CHEMBL4635978 Carbonic anhydrase 4 Homo sapiens 1197 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540915&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4718105 442142478 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336454 NS(=O)(=O)c1ccc(CCNCc2ccc3ccccc3c2)cc1 InChI=1S/C19H20N2O2S/c20-24(22,23)19-9-6-15(7-10-19)11-12-21-14-16-5-8-17-3-1-2-4-18(17)13-16/h1-10,13,21H,11-12,14H2,(H2,20,22,23) NVEXRVNVTDIFFP-UHFFFAOYSA-N 50540916 CHEMBL4640327 Carbonic anhydrase 4 Homo sapiens 6248 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540916&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156015191 442142479 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336455 NS(=O)(=O)c1ccc(CCNCc2ccco2)cc1 InChI=1S/C13H16N2O3S/c14-19(16,17)13-5-3-11(4-6-13)7-8-15-10-12-2-1-9-18-12/h1-6,9,15H,7-8,10H2,(H2,14,16,17) KPMDAPSHUTZFMM-UHFFFAOYSA-N 50540917 CHEMBL4637381 Carbonic anhydrase 4 Homo sapiens 1585 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540917&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4722624 442142480 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336456 NS(=O)(=O)c1ccc(CCNCC#N)cc1 InChI=1S/C10H13N3O2S/c11-6-8-13-7-5-9-1-3-10(4-2-9)16(12,14)15/h1-4,13H,5,7-8H2,(H2,12,14,15) FQWFYSWCAKLOPL-UHFFFAOYSA-N 50540918 CHEMBL4648292 Carbonic anhydrase 4 Homo sapiens 5547 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540918&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156020952 442142481 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336457 NS(=O)(=O)c1ccc(CCNCCc2ccccc2)cc1 InChI=1S/C16H20N2O2S/c17-21(19,20)16-8-6-15(7-9-16)11-13-18-12-10-14-4-2-1-3-5-14/h1-9,18H,10-13H2,(H2,17,19,20) SLYNTCCLMFDPHM-UHFFFAOYSA-N 50540919 CHEMBL4648008 Carbonic anhydrase 4 Homo sapiens 3587 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540919&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 17158039 442142482 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336458 CCN(CC)CC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccccc1 InChI=1S/C21H29N3O3S/c1-3-23(4-2)17-21(25)24(16-19-8-6-5-7-9-19)15-14-18-10-12-20(13-11-18)28(22,26)27/h5-13H,3-4,14-17H2,1-2H3,(H2,22,26,27) VYOWSELQIJBDCM-UHFFFAOYSA-N 50540920 CHEMBL4645453 Carbonic anhydrase 4 Homo sapiens 4148 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540920&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156019872 442142483 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336459 CCN(CC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccccc1)Cc1ccccc1 InChI=1S/C26H31N3O3S/c1-2-28(19-23-9-5-3-6-10-23)21-26(30)29(20-24-11-7-4-8-12-24)18-17-22-13-15-25(16-14-22)33(27,31)32/h3-16H,2,17-21H2,1H3,(H2,27,31,32) CVSXIGSVQBURIN-UHFFFAOYSA-N 50540921 CHEMBL4648208 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540921&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156021757 442142484 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336460 NS(=O)(=O)c1ccc(CCN(Cc2ccccc2)C(=O)CN(Cc2ccccc2)Cc2ccccc2)cc1 InChI=1S/C31H33N3O3S/c32-38(36,37)30-18-16-26(17-19-30)20-21-34(24-29-14-8-3-9-15-29)31(35)25-33(22-27-10-4-1-5-11-27)23-28-12-6-2-7-13-28/h1-19H,20-25H2,(H2,32,36,37) RJNIHLLGRIOAEL-UHFFFAOYSA-N 50540922 CHEMBL4632777 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540922&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156010056 442142485 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336461 CCCCCN(CCCCC)CC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccccc1 InChI=1S/C27H41N3O3S/c1-3-5-10-19-29(20-11-6-4-2)23-27(31)30(22-25-12-8-7-9-13-25)21-18-24-14-16-26(17-15-24)34(28,32)33/h7-9,12-17H,3-6,10-11,18-23H2,1-2H3,(H2,28,32,33) LZZOXVMUFQRWGH-UHFFFAOYSA-N 50540923 CHEMBL4635602 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540923&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156013611 442142486 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336462 CCCCCCN(CCCCCC)CC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccccc1 InChI=1S/C29H45N3O3S/c1-3-5-7-12-21-31(22-13-8-6-4-2)25-29(33)32(24-27-14-10-9-11-15-27)23-20-26-16-18-28(19-17-26)36(30,34)35/h9-11,14-19H,3-8,12-13,20-25H2,1-2H3,(H2,30,34,35) VDARWUMTDFLEHR-UHFFFAOYSA-N 50540924 CHEMBL4639808 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540924&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156015565 442142487 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336463 CCCCCCCN(CCCCCCC)CC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccccc1 InChI=1S/C31H49N3O3S/c1-3-5-7-9-14-23-33(24-15-10-8-6-4-2)27-31(35)34(26-29-16-12-11-13-17-29)25-22-28-18-20-30(21-19-28)38(32,36)37/h11-13,16-21H,3-10,14-15,22-27H2,1-2H3,(H2,32,36,37) IAFNLMIPUUPYRK-UHFFFAOYSA-N 50540925 CHEMBL4645984 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540925&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156019222 442142488 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336464 CCN(CC)CCC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccccc1 InChI=1S/C22H31N3O3S/c1-3-24(4-2)16-15-22(26)25(18-20-8-6-5-7-9-20)17-14-19-10-12-21(13-11-19)29(23,27)28/h5-13H,3-4,14-18H2,1-2H3,(H2,23,27,28) GICLORHBFNVJKE-UHFFFAOYSA-N 50540926 CHEMBL4646950 Carbonic anhydrase 4 Homo sapiens 3929 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540926&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156020244 442142489 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336465 CCN(CCC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccccc1)Cc1ccccc1 InChI=1S/C27H33N3O3S/c1-2-29(21-24-9-5-3-6-10-24)19-18-27(31)30(22-25-11-7-4-8-12-25)20-17-23-13-15-26(16-14-23)34(28,32)33/h3-16H,2,17-22H2,1H3,(H2,28,32,33) MGJGIGGEGAQZHA-UHFFFAOYSA-N 50540927 CHEMBL4648323 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540927&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156021421 442142490 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336466 NS(=O)(=O)c1ccc(CCN(Cc2ccccc2)C(=O)CCN(Cc2ccccc2)Cc2ccccc2)cc1 InChI=1S/C32H35N3O3S/c33-39(37,38)31-18-16-27(17-19-31)20-23-35(26-30-14-8-3-9-15-30)32(36)21-22-34(24-28-10-4-1-5-11-28)25-29-12-6-2-7-13-29/h1-19H,20-26H2,(H2,33,37,38) CBXOFGJWLFSLCW-UHFFFAOYSA-N 50540928 CHEMBL4648007 Carbonic anhydrase 4 Homo sapiens 4641 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540928&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156021312 442142491 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336467 CCCCCN(CCCCC)CCC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccccc1 InChI=1S/C28H43N3O3S/c1-3-5-10-20-30(21-11-6-4-2)22-19-28(32)31(24-26-12-8-7-9-13-26)23-18-25-14-16-27(17-15-25)35(29,33)34/h7-9,12-17H,3-6,10-11,18-24H2,1-2H3,(H2,29,33,34) GWVOOCRAGFOHPW-UHFFFAOYSA-N 50540929 CHEMBL4644301 Carbonic anhydrase 4 Homo sapiens 3245 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540929&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156017840 442142492 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336468 CCCCCCN(CCCCCC)CCC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccccc1 InChI=1S/C30H47N3O3S/c1-3-5-7-12-22-32(23-13-8-6-4-2)24-21-30(34)33(26-28-14-10-9-11-15-28)25-20-27-16-18-29(19-17-27)37(31,35)36/h9-11,14-19H,3-8,12-13,20-26H2,1-2H3,(H2,31,35,36) CCACHCVWBHKPGI-UHFFFAOYSA-N 50540930 CHEMBL4633224 Carbonic anhydrase 4 Homo sapiens 3455 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540930&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156011090 442142493 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336469 CCCCCCCCN(CCCCCCCC)CCC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccccc1 InChI=1S/C34H55N3O3S/c1-3-5-7-9-11-16-26-36(27-17-12-10-8-6-4-2)28-25-34(38)37(30-32-18-14-13-15-19-32)29-24-31-20-22-33(23-21-31)41(35,39)40/h13-15,18-23H,3-12,16-17,24-30H2,1-2H3,(H2,35,39,40) CLZOLSSCBUWCBW-UHFFFAOYSA-N 50540931 CHEMBL4648117 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540931&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156020732 442142494 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336470 CCCCCN(CCCCC)CCC(=O)N(CCc1ccccc1)CCc1ccc(cc1)S(N)(=O)=O InChI=1S/C29H45N3O3S/c1-3-5-10-21-31(22-11-6-4-2)23-20-29(33)32(24-18-26-12-8-7-9-13-26)25-19-27-14-16-28(17-15-27)36(30,34)35/h7-9,12-17H,3-6,10-11,18-25H2,1-2H3,(H2,30,34,35) LAVYDIRHIGPPCP-UHFFFAOYSA-N 50540932 CHEMBL4648531 Carbonic anhydrase 4 Homo sapiens 3413 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540932&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156020417 442142495 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336471 CCCCCN(CCCCC)CCC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccco1 InChI=1S/C26H41N3O4S/c1-3-5-7-17-28(18-8-6-4-2)19-16-26(30)29(22-24-10-9-21-33-24)20-15-23-11-13-25(14-12-23)34(27,31)32/h9-14,21H,3-8,15-20,22H2,1-2H3,(H2,27,31,32) RCOKPKGAYZZBIN-UHFFFAOYSA-N 50540933 CHEMBL4641658 Carbonic anhydrase 4 Homo sapiens 3154 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540933&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156016187 442142496 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336472 CCCCCN(CCCCC)CC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccc2ccccc2c1 InChI=1S/C31H43N3O3S/c1-3-5-9-20-33(21-10-6-4-2)25-31(35)34(22-19-26-14-17-30(18-15-26)38(32,36)37)24-27-13-16-28-11-7-8-12-29(28)23-27/h7-8,11-18,23H,3-6,9-10,19-22,24-25H2,1-2H3,(H2,32,36,37) QZUYDXMQCPDHKJ-UHFFFAOYSA-N 50540934 CHEMBL4635898 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540934&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156014582 442142497 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336473 CCCCCN(CCCCC)CC(=O)N(CCC#N)CCc1ccc(cc1)S(N)(=O)=O InChI=1S/C23H38N4O3S/c1-3-5-7-16-26(17-8-6-4-2)20-23(28)27(18-9-15-24)19-14-21-10-12-22(13-11-21)31(25,29)30/h10-13H,3-9,14,16-20H2,1-2H3,(H2,25,29,30) FSGVGYOCCLVCPR-UHFFFAOYSA-N 50540935 CHEMBL4643523 Carbonic anhydrase 4 Homo sapiens 3478 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540935&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156017913 442142498 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336474 NS(=O)(=O)c1ccc(CCN(CCc2ccccc2)C(=O)CN(CCC#N)CCc2ccccc2)cc1 InChI=1S/C29H34N4O3S/c30-19-7-20-32(21-16-25-8-3-1-4-9-25)24-29(34)33(22-17-26-10-5-2-6-11-26)23-18-27-12-14-28(15-13-27)37(31,35)36/h1-6,8-15H,7,16-18,20-24H2,(H2,31,35,36) XZPNEWBDLFUWEA-UHFFFAOYSA-N 50540936 CHEMBL4649113 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540936&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search U7A 6WQ4 146171279 442142499 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336475 NS(=O)(=O)c1ccc(CCN(Cc2ccco2)C(=O)CN(CCC#N)CCc2ccccc2)cc1 InChI=1S/C26H30N4O4S/c27-15-5-16-29(17-13-22-6-2-1-3-7-22)21-26(31)30(20-24-8-4-19-34-24)18-14-23-9-11-25(12-10-23)35(28,32)33/h1-4,6-12,19H,5,13-14,16-18,20-21H2,(H2,28,32,33) QJCJESHARPLDPI-UHFFFAOYSA-N 50540937 CHEMBL4647614 Carbonic anhydrase 4 Homo sapiens 457 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540937&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156021145 442142500 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336476 NS(=O)(=O)c1ccc(CCN(Cc2ccc(F)cc2)C(=O)CN(CCC#N)CCc2ccccc2)cc1 InChI=1S/C28H31FN4O3S/c29-26-11-7-25(8-12-26)21-33(20-16-24-9-13-27(14-10-24)37(31,35)36)28(34)22-32(18-4-17-30)19-15-23-5-2-1-3-6-23/h1-3,5-14H,4,15-16,18-22H2,(H2,31,35,36) YBIJNZHHAMTRHM-UHFFFAOYSA-N 50540938 CHEMBL4644738 Carbonic anhydrase 4 Homo sapiens 4134 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540938&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156017855 442142501 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336477 NS(=O)(=O)c1ccc(CCN(Cc2ccc3ccccc3c2)C(=O)CN(CCC#N)CCc2ccccc2)cc1 InChI=1S/C32H34N4O3S/c33-19-6-20-35(21-17-26-7-2-1-3-8-26)25-32(37)36(22-18-27-12-15-31(16-13-27)40(34,38)39)24-28-11-14-29-9-4-5-10-30(29)23-28/h1-5,7-16,23H,6,17-18,20-22,24-25H2,(H2,34,38,39) LOIJSEMKLMLMGX-UHFFFAOYSA-N 50540939 CHEMBL4648263 Carbonic anhydrase 4 Homo sapiens 3813 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540939&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156020611 442142502 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336478 NS(=O)(=O)c1ccc(CCN(Cc2ccc(cc2)[N+]([O-])=O)C(=O)CN(CCC#N)CCc2ccccc2)cc1 InChI=1S/C28H31N5O5S/c29-17-4-18-31(19-15-23-5-2-1-3-6-23)22-28(34)32(21-25-7-11-26(12-8-25)33(35)36)20-16-24-9-13-27(14-10-24)39(30,37)38/h1-3,5-14H,4,15-16,18-22H2,(H2,30,37,38) CCKAJIGVRVSHPG-UHFFFAOYSA-N 50540940 CHEMBL4642443 Carbonic anhydrase 4 Homo sapiens 2422 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540940&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156016537 442142503 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336479 NS(=O)(=O)c1ccc(CCN(CC#N)C(=O)CN(CCC#N)CCc2ccccc2)cc1 InChI=1S/C23H27N5O3S/c24-13-4-15-27(16-11-20-5-2-1-3-6-20)19-23(29)28(18-14-25)17-12-21-7-9-22(10-8-21)32(26,30)31/h1-3,5-10H,4,11-12,15-19H2,(H2,26,30,31) KECAIXMRWZWYDK-UHFFFAOYSA-N 50540941 CHEMBL4633228 Carbonic anhydrase 4 Homo sapiens 727 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540941&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156009494 442142504 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336480 NCCCN(CCc1ccccc1)CC(=O)N(CCc1ccccc1)CCc1ccc(cc1)S(N)(=O)=O InChI=1S/C29H38N4O3S/c30-19-7-20-32(21-16-25-8-3-1-4-9-25)24-29(34)33(22-17-26-10-5-2-6-11-26)23-18-27-12-14-28(15-13-27)37(31,35)36/h1-6,8-15H,7,16-24,30H2,(H2,31,35,36) IZHCFMDCLZJGQJ-UHFFFAOYSA-N 50540942 CHEMBL4646611 Carbonic anhydrase 4 Homo sapiens 2149 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540942&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156019863 442142505 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336481 NCCCN(CCc1ccccc1)CC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccco1 InChI=1S/C26H34N4O4S/c27-15-5-16-29(17-13-22-6-2-1-3-7-22)21-26(31)30(20-24-8-4-19-34-24)18-14-23-9-11-25(12-10-23)35(28,32)33/h1-4,6-12,19H,5,13-18,20-21,27H2,(H2,28,32,33) UAMDHZJOGXWLGH-UHFFFAOYSA-N 50540943 CHEMBL4633807 Carbonic anhydrase 4 Homo sapiens 374 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540943&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search U7G 6WQ5 146171280 442142506 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336482 NCCCN(CCc1ccccc1)CC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccc(F)cc1 InChI=1S/C28H35FN4O3S/c29-26-11-7-25(8-12-26)21-33(20-16-24-9-13-27(14-10-24)37(31,35)36)28(34)22-32(18-4-17-30)19-15-23-5-2-1-3-6-23/h1-3,5-14H,4,15-22,30H2,(H2,31,35,36) PTOFZDQATQXAPS-UHFFFAOYSA-N 50540944 CHEMBL4637053 Carbonic anhydrase 4 Homo sapiens 365 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540944&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search U6V 6WQ7,7SV1 146171281 442142507 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336483 NCCCN(CCc1ccccc1)CC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccc2ccccc2c1 InChI=1S/C32H38N4O3S/c33-19-6-20-35(21-17-26-7-2-1-3-8-26)25-32(37)36(22-18-27-12-15-31(16-13-27)40(34,38)39)24-28-11-14-29-9-4-5-10-30(29)23-28/h1-5,7-16,23H,6,17-22,24-25,33H2,(H2,34,38,39) SIPQDBCPJNBECH-UHFFFAOYSA-N 50540945 CHEMBL4641798 Carbonic anhydrase 4 Homo sapiens 819 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540945&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156017087 442142508 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336484 CCCCCCN(CCCCCC)CC(=O)N(CCCN)CCc1ccc(cc1)S(N)(=O)=O InChI=1S/C25H46N4O3S/c1-3-5-7-9-18-28(19-10-8-6-4-2)22-25(30)29(20-11-17-26)21-16-23-12-14-24(15-13-23)33(27,31)32/h12-15H,3-11,16-22,26H2,1-2H3,(H2,27,31,32) BNSRXXIXPBNAGL-UHFFFAOYSA-N 50540946 CHEMBL4644606 Carbonic anhydrase 4 Homo sapiens 914 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540946&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156018473 442142509 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336485 NS(=O)(=O)c1ccc(CCN(CCc2ccccc2)C(=O)CN(CCC(O)=O)CCc2ccccc2)cc1 InChI=1S/C29H35N3O5S/c30-38(36,37)27-13-11-26(12-14-27)17-22-32(21-16-25-9-5-2-6-10-25)28(33)23-31(20-18-29(34)35)19-15-24-7-3-1-4-8-24/h1-14H,15-23H2,(H,34,35)(H2,30,36,37) VPHFSXSBVSHQKZ-UHFFFAOYSA-N 50540947 CHEMBL4638497 Carbonic anhydrase 4 Homo sapiens 2331 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540947&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156012386 442142510 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336486 NS(=O)(=O)c1ccc(CCN(Cc2ccco2)C(=O)CN(CCC(O)=O)CCc2ccccc2)cc1 InChI=1S/C26H31N3O6S/c27-36(33,34)24-10-8-22(9-11-24)13-17-29(19-23-7-4-18-35-23)25(30)20-28(16-14-26(31)32)15-12-21-5-2-1-3-6-21/h1-11,18H,12-17,19-20H2,(H,31,32)(H2,27,33,34) VOLPYGCWCBVKEI-UHFFFAOYSA-N 50540948 CHEMBL4633714 Carbonic anhydrase 4 Homo sapiens 336 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540948&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search U77 7SUW,6WQ8 146171282 442142511 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336487 NS(=O)(=O)c1ccc(CCN(Cc2ccc(F)cc2)C(=O)CN(CCC(O)=O)CCc2ccccc2)cc1 InChI=1S/C28H32FN3O5S/c29-25-10-6-24(7-11-25)20-32(19-15-23-8-12-26(13-9-23)38(30,36)37)27(33)21-31(18-16-28(34)35)17-14-22-4-2-1-3-5-22/h1-13H,14-21H2,(H,34,35)(H2,30,36,37) NGJNMKMKJJDMSK-UHFFFAOYSA-N 50540949 CHEMBL4641115 Carbonic anhydrase 4 Homo sapiens 419 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540949&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156015956 442142512 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336488 NS(=O)(=O)c1ccc(CCN(Cc2ccc3ccccc3c2)C(=O)CN(CCC(O)=O)CCc2ccccc2)cc1 InChI=1S/C32H35N3O5S/c33-41(39,40)30-14-11-26(12-15-30)17-21-35(23-27-10-13-28-8-4-5-9-29(28)22-27)31(36)24-34(20-18-32(37)38)19-16-25-6-2-1-3-7-25/h1-15,22H,16-21,23-24H2,(H,37,38)(H2,33,39,40) PYCJQGYVMKZBRZ-UHFFFAOYSA-N 50540950 CHEMBL4642599 Carbonic anhydrase 4 Homo sapiens 681 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540950&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search U7J 6WQ9,7SV8 146171283 442142513 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336489 CCCCCCN(CCCCCC)CC(=O)N(CCC(O)=O)CCc1ccc(cc1)S(N)(=O)=O InChI=1S/C25H43N3O5S/c1-3-5-7-9-17-27(18-10-8-6-4-2)21-24(29)28(20-16-25(30)31)19-15-22-11-13-23(14-12-22)34(26,32)33/h11-14H,3-10,15-21H2,1-2H3,(H,30,31)(H2,26,32,33) DJQVHAFUQICALS-UHFFFAOYSA-N 50540951 CHEMBL4644136 Carbonic anhydrase 4 Homo sapiens 46 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540951&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156018091 442142514 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336490 CCCCCCCC\C=C/CCCCCCCCNC(=O)CCN(CCc1ccccc1)CC(=O)N(CCc1ccc(cc1)S(N)(=O)=O)Cc1ccco1 InChI=1S/C44H66N4O5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-32-46-43(49)31-34-47(33-29-39-22-18-17-19-23-39)38-44(50)48(37-41-24-21-36-53-41)35-30-40-25-27-42(28-26-40)54(45,51)52/h9-10,17-19,21-28,36H,2-8,11-16,20,29-35,37-38H2,1H3,(H,46,49)(H2,45,51,52)/b10-9- ZOMYHORNQJUIAU-KTKRTIGZSA-N 50540952 CHEMBL4649226 Carbonic anhydrase 4 Homo sapiens 1807 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540952&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 156020550 442142515 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51336491 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.0c00733 10.7270/Q2BV7M64 32519851 Bonardi, A; Nocentini, A; Bua, S; Combs, J; Lomelino, C; Andring, J; Lucarini, L; Sgambellone, S; Masini, E; McKenna, R; Gratteri, P; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51393110 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 8.6 ChEMBL 10.1021/acs.jmedchem.0c02077 10.7270/Q2C25158 33523653 Mboge, MY; Combs, J; Singh, S; Andring, J; Wolff, A; Tu, C; Zhang, Z; McKenna, R; Frost, SC University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51393111 NS(=O)(=O)c1ccc(cc1)N1CCN(C1=O)c1ccc(F)cc1F InChI=1S/C15H13F2N3O3S/c16-10-1-6-14(13(17)9-10)20-8-7-19(15(20)21)11-2-4-12(5-3-11)24(18,22)23/h1-6,9H,7-8H2,(H2,18,22,23) SGCKOJXZNTVQLM-UHFFFAOYSA-N 50562972 CHEMBL4799997 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.0c02077 10.7270/Q2C25158 33523653 Mboge, MY; Combs, J; Singh, S; Andring, J; Wolff, A; Tu, C; Zhang, Z; McKenna, R; Frost, SC University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562972&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 124174639 461683310 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377155 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccccc2)cc1 InChI=1S/C15H18N4O5S2/c16-26(23,24)14-8-6-13(7-9-14)19-25(21,22)11-10-17-15(20)18-12-4-2-1-3-5-12/h1-9,19H,10-11H2,(H2,16,23,24)(H2,17,18,20) JWGFBEXNOWIWRP-UHFFFAOYSA-N 50556831 CHEMBL4754131 Carbonic anhydrase 4 Homo sapiens 723 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556831&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search VYV 7K6I,7K6T 155289400 461695599 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377156 Cc1ccccc1NC(=O)NCCS(=O)(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C16H20N4O5S2/c1-12-4-2-3-5-15(12)19-16(21)18-10-11-26(22,23)20-13-6-8-14(9-7-13)27(17,24)25/h2-9,20H,10-11H2,1H3,(H2,17,24,25)(H2,18,19,21) ATRAHZJHRAFDIJ-UHFFFAOYSA-N 50556830 CHEMBL4743404 Carbonic anhydrase 4 Homo sapiens 926 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556830&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162646620 461695598 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377157 Cc1ccc(NC(=O)NCCS(=O)(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C16H20N4O5S2/c1-12-2-4-13(5-3-12)19-16(21)18-10-11-26(22,23)20-14-6-8-15(9-7-14)27(17,24)25/h2-9,20H,10-11H2,1H3,(H2,17,24,25)(H2,18,19,21) YDAOBULQBPBUCA-UHFFFAOYSA-N 50556832 CHEMBL4746869 Carbonic anhydrase 4 Homo sapiens 89 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556832&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search VYY 7K6J,7K6U 155289401 461695600 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377158 Cc1cc(C)cc(NC(=O)NCCS(=O)(=O)Nc2ccc(cc2)S(N)(=O)=O)c1 InChI=1S/C17H22N4O5S2/c1-12-9-13(2)11-15(10-12)20-17(22)19-7-8-27(23,24)21-14-3-5-16(6-4-14)28(18,25)26/h3-6,9-11,21H,7-8H2,1-2H3,(H2,18,25,26)(H2,19,20,22) BZBHIVDNNVDCQT-UHFFFAOYSA-N 50556833 CHEMBL4751791 Carbonic anhydrase 4 Homo sapiens 965 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556833&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search VZ1 7K6K,7K6X 155289402 461695601 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377159 CCc1ccccc1NC(=O)NCCS(=O)(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C17H22N4O5S2/c1-2-13-5-3-4-6-16(13)20-17(22)19-11-12-27(23,24)21-14-7-9-15(10-8-14)28(18,25)26/h3-10,21H,2,11-12H2,1H3,(H2,18,25,26)(H2,19,20,22) RNBCGDGLONSUIF-UHFFFAOYSA-N 50556834 CHEMBL4796007 Carbonic anhydrase 4 Homo sapiens 1403 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556834&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162674235 461695602 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377160 CCc1ccc(NC(=O)NCCS(=O)(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C17H22N4O5S2/c1-2-13-3-5-14(6-4-13)20-17(22)19-11-12-27(23,24)21-15-7-9-16(10-8-15)28(18,25)26/h3-10,21H,2,11-12H2,1H3,(H2,18,25,26)(H2,19,20,22) TZIKAGOBNORGDA-UHFFFAOYSA-N 50556835 CHEMBL4740821 Carbonic anhydrase 4 Homo sapiens 580 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556835&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162644672 461695603 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377161 CCCCc1ccc(NC(=O)NCCS(=O)(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C19H26N4O5S2/c1-2-3-4-15-5-7-16(8-6-15)22-19(24)21-13-14-29(25,26)23-17-9-11-18(12-10-17)30(20,27)28/h5-12,23H,2-4,13-14H2,1H3,(H2,20,27,28)(H2,21,22,24) VDRAHCKGJIOZHN-UHFFFAOYSA-N 50556836 CHEMBL4751921 Carbonic anhydrase 4 Homo sapiens 1344 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556836&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162653433 461695604 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377162 CC(C)(C)c1ccc(NC(=O)NCCS(=O)(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C19H26N4O5S2/c1-19(2,3)14-4-6-15(7-5-14)22-18(24)21-12-13-29(25,26)23-16-8-10-17(11-9-16)30(20,27)28/h4-11,23H,12-13H2,1-3H3,(H2,20,27,28)(H2,21,22,24) XGIJNCDMAVBREM-UHFFFAOYSA-N 50556837 CHEMBL4750727 Carbonic anhydrase 4 Homo sapiens 52 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556837&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162651136 461695605 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377163 CCCCOc1ccc(NC(=O)NCCS(=O)(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C19H26N4O6S2/c1-2-3-13-29-17-8-4-15(5-9-17)22-19(24)21-12-14-30(25,26)23-16-6-10-18(11-7-16)31(20,27)28/h4-11,23H,2-3,12-14H2,1H3,(H2,20,27,28)(H2,21,22,24) BOTDZEGDCZIKRS-UHFFFAOYSA-N 50556838 CHEMBL4756185 Carbonic anhydrase 4 Homo sapiens 1047 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556838&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162655742 461695606 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377164 COc1ccccc1NC(=O)NCCS(=O)(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C16H20N4O6S2/c1-26-15-5-3-2-4-14(15)19-16(21)18-10-11-27(22,23)20-12-6-8-13(9-7-12)28(17,24)25/h2-9,20H,10-11H2,1H3,(H2,17,24,25)(H2,18,19,21) NUBNECLTKQKFKV-UHFFFAOYSA-N 50556839 CHEMBL4751213 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556839&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162651162 461695607 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377165 COc1ccc(NC(=O)NCCS(=O)(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C16H20N4O6S2/c1-26-14-6-2-12(3-7-14)19-16(21)18-10-11-27(22,23)20-13-4-8-15(9-5-13)28(17,24)25/h2-9,20H,10-11H2,1H3,(H2,17,24,25)(H2,18,19,21) YTKAFKXVZBIBGM-UHFFFAOYSA-N 50556840 CHEMBL4763261 Carbonic anhydrase 4 Homo sapiens 978 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556840&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162659008 461695608 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377166 COc1ccc(NC(=O)NCCS(=O)(=O)Nc2ccc(cc2)S(N)(=O)=O)c(OC)c1 InChI=1S/C17H22N4O7S2/c1-27-13-5-8-15(16(11-13)28-2)20-17(22)19-9-10-29(23,24)21-12-3-6-14(7-4-12)30(18,25)26/h3-8,11,21H,9-10H2,1-2H3,(H2,18,25,26)(H2,19,20,22) YHDQKRLQEYIZTD-UHFFFAOYSA-N 50556841 CHEMBL4785797 Carbonic anhydrase 4 Homo sapiens 1079 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556841&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162667381 461695609 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377167 CSc1ccc(NC(=O)NCCS(=O)(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C16H20N4O5S3/c1-26-14-6-2-12(3-7-14)19-16(21)18-10-11-27(22,23)20-13-4-8-15(9-5-13)28(17,24)25/h2-9,20H,10-11H2,1H3,(H2,17,24,25)(H2,18,19,21) BYMVMKJBRUWEDE-UHFFFAOYSA-N 50556842 CHEMBL4755318 Carbonic anhydrase 4 Homo sapiens 1055 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556842&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162654223 461695610 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377168 Cc1ccc(Cl)c(NC(=O)NCCS(=O)(=O)Nc2ccc(cc2)S(N)(=O)=O)c1 InChI=1S/C16H19ClN4O5S2/c1-11-2-7-14(17)15(10-11)20-16(22)19-8-9-27(23,24)21-12-3-5-13(6-4-12)28(18,25)26/h2-7,10,21H,8-9H2,1H3,(H2,18,25,26)(H2,19,20,22) ZXZHTJNNFHZERH-UHFFFAOYSA-N 50556843 CHEMBL4794443 Carbonic anhydrase 4 Homo sapiens 922 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556843&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162672368 461695611 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377169 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccccc2Cl)cc1 InChI=1S/C15H17ClN4O5S2/c16-13-3-1-2-4-14(13)19-15(21)18-9-10-26(22,23)20-11-5-7-12(8-6-11)27(17,24)25/h1-8,20H,9-10H2,(H2,17,24,25)(H2,18,19,21) GJBRFDMGNAWWCF-UHFFFAOYSA-N 50556844 CHEMBL4777414 Carbonic anhydrase 4 Homo sapiens 165 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556844&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162643038 461695612 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377170 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccc(Cl)cc2)cc1 InChI=1S/C15H17ClN4O5S2/c16-11-1-3-12(4-2-11)19-15(21)18-9-10-26(22,23)20-13-5-7-14(8-6-13)27(17,24)25/h1-8,20H,9-10H2,(H2,17,24,25)(H2,18,19,21) LROWEQWLRCXFQZ-UHFFFAOYSA-N 50556845 CHEMBL4794498 Carbonic anhydrase 4 Homo sapiens 162 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556845&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162672869 461695613 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377171 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccc(F)cc2)cc1 InChI=1S/C15H17FN4O5S2/c16-11-1-3-12(4-2-11)19-15(21)18-9-10-26(22,23)20-13-5-7-14(8-6-13)27(17,24)25/h1-8,20H,9-10H2,(H2,17,24,25)(H2,18,19,21) RNTJUUSYPCOMRZ-UHFFFAOYSA-N 50556846 CHEMBL4781400 Carbonic anhydrase 4 Homo sapiens 404 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556846&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search VZD 7K6L,7K6Z 155289403 461695614 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377172 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccc(F)cc2F)cc1 InChI=1S/C15H16F2N4O5S2/c16-10-1-6-14(13(17)9-10)20-15(22)19-7-8-27(23,24)21-11-2-4-12(5-3-11)28(18,25)26/h1-6,9,21H,7-8H2,(H2,18,25,26)(H2,19,20,22) RYLWUJYKKSBOAJ-UHFFFAOYSA-N 50556847 CHEMBL4757061 Carbonic anhydrase 4 Homo sapiens 1051 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556847&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162656655 461695615 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377173 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2c(F)c(F)c(F)c(F)c2F)cc1 InChI=1S/C15H13F5N4O5S2/c16-9-10(17)12(19)14(13(20)11(9)18)23-15(25)22-5-6-30(26,27)24-7-1-3-8(4-2-7)31(21,28)29/h1-4,24H,5-6H2,(H2,21,28,29)(H2,22,23,25) ZSYKTLDQSMAEFY-UHFFFAOYSA-N 50556848 CHEMBL4789227 Carbonic anhydrase 4 Homo sapiens 236 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556848&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162668545 461695616 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377174 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccc(Br)cc2)cc1 InChI=1S/C15H17BrN4O5S2/c16-11-1-3-12(4-2-11)19-15(21)18-9-10-26(22,23)20-13-5-7-14(8-6-13)27(17,24)25/h1-8,20H,9-10H2,(H2,17,24,25)(H2,18,19,21) JYJRCFANFXWVAO-UHFFFAOYSA-N 50556849 CHEMBL4756246 Carbonic anhydrase 4 Homo sapiens 32 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556849&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162655147 461695617 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377175 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccc(cc2)[N+]([O-])=O)cc1 InChI=1S/C15H17N5O7S2/c16-29(26,27)14-7-3-12(4-8-14)19-28(24,25)10-9-17-15(21)18-11-1-5-13(6-2-11)20(22)23/h1-8,19H,9-10H2,(H2,16,26,27)(H2,17,18,21) UMYGCMORXGSBRC-UHFFFAOYSA-N 50556850 CHEMBL4758359 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556850&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162656547 461695618 C02125 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377176 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C16H17F3N4O5S2/c17-16(18,19)11-1-3-12(4-2-11)22-15(24)21-9-10-29(25,26)23-13-5-7-14(8-6-13)30(20,27)28/h1-8,23H,9-10H2,(H2,20,27,28)(H2,21,22,24) XHYJUBYDAVQIEZ-UHFFFAOYSA-N 50556851 CHEMBL4744099 Carbonic anhydrase 4 Homo sapiens 66 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556851&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162646003 461695619 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377177 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccc(cc2)-c2ccccc2)cc1 InChI=1S/C21H22N4O5S2/c22-32(29,30)20-12-10-19(11-13-20)25-31(27,28)15-14-23-21(26)24-18-8-6-17(7-9-18)16-4-2-1-3-5-16/h1-13,25H,14-15H2,(H2,22,29,30)(H2,23,24,26) ANSUAKRJHZFIKU-UHFFFAOYSA-N 50556852 CHEMBL4798904 Carbonic anhydrase 4 Homo sapiens 1680 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556852&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162675816 461695620 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377178 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccc(Oc3ccccc3)cc2)cc1 InChI=1S/C21H22N4O6S2/c22-33(29,30)20-12-8-17(9-13-20)25-32(27,28)15-14-23-21(26)24-16-6-10-19(11-7-16)31-18-4-2-1-3-5-18/h1-13,25H,14-15H2,(H2,22,29,30)(H2,23,24,26) NAABYVVCZSXBRE-UHFFFAOYSA-N 50556853 CHEMBL4745103 Carbonic anhydrase 4 Homo sapiens 1306 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556853&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162648828 461695621 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377179 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2ccc3CCCc3c2)cc1 InChI=1S/C18H22N4O5S2/c19-29(26,27)17-8-6-15(7-9-17)22-28(24,25)11-10-20-18(23)21-16-5-4-13-2-1-3-14(13)12-16/h4-9,12,22H,1-3,10-11H2,(H2,19,26,27)(H2,20,21,23) HXWPNVVSLDCVCF-UHFFFAOYSA-N 50556854 CHEMBL4740854 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556854&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162646022 461695622 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377180 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)Nc2cccc3ccccc23)cc1 InChI=1S/C19H20N4O5S2/c20-30(27,28)16-10-8-15(9-11-16)23-29(25,26)13-12-21-19(24)22-18-7-3-5-14-4-1-2-6-17(14)18/h1-11,23H,12-13H2,(H2,20,27,28)(H2,21,22,24) KRFNOZSITCGEBH-UHFFFAOYSA-N 50556855 CHEMBL4744521 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556855&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162648500 461695623 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377181 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)NCc2ccco2)cc1 InChI=1S/C14H18N4O6S2/c15-26(22,23)13-5-3-11(4-6-13)18-25(20,21)9-7-16-14(19)17-10-12-2-1-8-24-12/h1-6,8,18H,7,9-10H2,(H2,15,22,23)(H2,16,17,19) MJHMKXYWUQLOTN-UHFFFAOYSA-N 50556856 CHEMBL4756560 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556856&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162655632 461695624 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377182 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 InChI=1S/C19H28N4O5S2/c20-30(27,28)17-3-1-16(2-4-17)23-29(25,26)6-5-21-18(24)22-19-10-13-7-14(11-19)9-15(8-13)12-19/h1-4,13-15,23H,5-12H2,(H2,20,27,28)(H2,21,22,24) CJLSMARBIMWEEM-UHFFFAOYSA-N 50556857 CHEMBL4792769 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556857&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162671246 461695625 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377183 NS(=O)(=O)c1ccc(NS(=O)(=O)CCNC(=O)NCc2ccccc2)cc1 InChI=1S/C16H20N4O5S2/c17-27(24,25)15-8-6-14(7-9-15)20-26(22,23)11-10-18-16(21)19-12-13-4-2-1-3-5-13/h1-9,20H,10-12H2,(H2,17,24,25)(H2,18,19,21) GRFLMRGGHAVHMQ-UHFFFAOYSA-N 50556858 CHEMBL4750266 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50556858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50556858&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162652424 461695626 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51377184 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2020.113035 10.7270/Q26T0RBB 33303238 Akgul, O; Singh, S; Andring, JT; McKenna, R; Selleri, S; Carta, F; Angeli, A; Supuran, CT Ege University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391357 OC1(O)C(=O)c2cccc(F)c2C1=O InChI=1S/C9H5FO4/c10-5-3-1-2-4-6(5)8(12)9(13,14)7(4)11/h1-3,13-14H ZYOWGKVMQVHSGM-UHFFFAOYSA-N 50562191 CHEMBL4780621 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562191&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 15287798 461832583 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391358 Oc1cccc2C(=O)C(O)(O)C(=O)c12 InChI=1S/C9H6O5/c10-5-3-1-2-4-6(5)8(12)9(13,14)7(4)11/h1-3,10,13-14H WADCFSVAUBQADP-UHFFFAOYSA-N 50562192 CHEMBL4762664 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562192&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 86716858 461832584 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391359 CC(C)Oc1cccc2C(=O)C(O)(O)C(=O)c12 InChI=1S/C12H12O5/c1-6(2)17-8-5-3-4-7-9(8)11(14)12(15,16)10(7)13/h3-6,15-16H,1-2H3 LVVHGEAEYBFUJZ-UHFFFAOYSA-N 50562193 CHEMBL4782653 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562193&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162664877 461832585 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391360 COc1cccc2C(=O)C(O)(O)C(=O)c12 InChI=1S/C10H8O5/c1-15-6-4-2-3-5-7(6)9(12)10(13,14)8(5)11/h2-4,13-14H,1H3 XVWORVSADFUVQP-UHFFFAOYSA-N 50562194 CHEMBL4798972 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562194&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 184662 461832586 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391361 Cc1cccc2C(=O)C(O)(O)C(=O)c12 InChI=1S/C10H8O4/c1-5-3-2-4-6-7(5)9(12)10(13,14)8(6)11/h2-4,13-14H,1H3 ZZSIKUNRUHSIJN-UHFFFAOYSA-N 50562195 CHEMBL4778728 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562195&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 69701117 461832587 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391362 OC1(O)C(=O)c2cccc(c2C1=O)[N+]([O-])=O InChI=1S/C9H5NO6/c11-7-4-2-1-3-5(10(15)16)6(4)8(12)9(7,13)14/h1-3,13-14H KWUIGWLZVAPWQV-UHFFFAOYSA-N 50562196 CHEMBL4759493 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562196&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 157712 461832588 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391363 OC1(O)C(=O)c2cccc(Br)c2C1=O InChI=1S/C9H5BrO4/c10-5-3-1-2-4-6(5)8(12)9(13,14)7(4)11/h1-3,13-14H OUPPTNNPUSWEFC-UHFFFAOYSA-N 50562197 CHEMBL4756518 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562197&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145841069 461832589 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391364 Cc1ccc2C(=O)C(O)(O)C(=O)c2c1 InChI=1S/C10H8O4/c1-5-2-3-6-7(4-5)9(12)10(13,14)8(6)11/h2-4,13-14H,1H3 YSFDBEXXZHVVAE-UHFFFAOYSA-N 50562198 CHEMBL4750896 Carbonic anhydrase 4 Homo sapiens 84600 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562198&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 69700335 461832590 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391365 OC1(O)C(=O)c2ccc(F)cc2C1=O InChI=1S/C9H5FO4/c10-4-1-2-5-6(3-4)8(12)9(13,14)7(5)11/h1-3,13-14H FGEXOKDSGCWVPT-UHFFFAOYSA-N 50562199 CHEMBL4791718 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562199&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 22361311 461832591 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391366 OC1(O)C(=O)c2ccc(cc2C1=O)[N+]([O-])=O InChI=1S/C9H5NO6/c11-7-5-2-1-4(10(15)16)3-6(5)8(12)9(7,13)14/h1-3,13-14H CKNXPOACSQXSGF-UHFFFAOYSA-N 50562200 CHEMBL4754929 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562200&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 184656 461832592 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391367 OC1(O)C(=O)c2ccc(Br)cc2C1=O InChI=1S/C9H5BrO4/c10-4-1-2-5-6(3-4)8(12)9(13,14)7(5)11/h1-3,13-14H GLMZVCJEVXJYSV-UHFFFAOYSA-N 50562201 CHEMBL4760795 Carbonic anhydrase 4 Homo sapiens 71300 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562201&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 85802270 461832593 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391368 Oc1ccc2C(=O)C(O)(O)C(=O)c2c1 InChI=1S/C9H6O5/c10-4-1-2-5-6(3-4)8(12)9(13,14)7(5)11/h1-3,10,13-14H SIHOECBIWVLNDE-UHFFFAOYSA-N 50562202 CHEMBL4793537 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562202&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 86716869 461832594 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391369 COc1ccc2C(=O)C(O)(O)C(=O)c2c1 InChI=1S/C10H8O5/c1-15-5-2-3-6-7(4-5)9(12)10(13,14)8(6)11/h2-4,13-14H,1H3 CHRLGTHYCGMMQQ-UHFFFAOYSA-N 50562203 CHEMBL4783894 Carbonic anhydrase 4 Homo sapiens 74300 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562203&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 184663 461832595 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391370 COc1ccc(C(C)C)c2C(=O)C(O)(O)C(=O)c12 InChI=1S/C13H14O5/c1-6(2)7-4-5-8(18-3)10-9(7)11(14)13(16,17)12(10)15/h4-6,16-17H,1-3H3 PXHQIRFPVXVSCM-UHFFFAOYSA-N 50562204 CHEMBL4794500 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562204&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162673034 461832596 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391371 COc1ccc(CNC(=O)CCl)c2C(=O)C(O)(O)C(=O)c12 InChI=1S/C13H12ClNO6/c1-21-7-3-2-6(5-15-8(16)4-14)9-10(7)12(18)13(19,20)11(9)17/h2-3,19-20H,4-5H2,1H3,(H,15,16) NSDKREDPVCOGGW-UHFFFAOYSA-N 50562205 CHEMBL4757527 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562205&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162657331 461832597 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391372 COc1ccc(OC)c2C(=O)C(O)(O)C(=O)c12 InChI=1S/C11H10O6/c1-16-5-3-4-6(17-2)8-7(5)9(12)11(14,15)10(8)13/h3-4,14-15H,1-2H3 YZNPQMQPXQZXCM-UHFFFAOYSA-N 50562206 CHEMBL4786348 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562206&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162667219 461832598 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391373 COc1cc2C(=O)C(O)(O)C(=O)c2cc1OC InChI=1S/C11H10O6/c1-16-7-3-5-6(4-8(7)17-2)10(13)11(14,15)9(5)12/h3-4,14-15H,1-2H3 PYUKMKNQONAROX-UHFFFAOYSA-N 50562207 CHEMBL4760657 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562207&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 182143 461832599 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391374 OC1(O)C(=O)c2cc(Br)cc(Br)c2C1=O InChI=1S/C9H4Br2O4/c10-3-1-4-6(5(11)2-3)8(13)9(14,15)7(4)12/h1-2,14-15H PIVDGZKJNCLWFF-UHFFFAOYSA-N 50562208 CHEMBL4747211 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562208&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162650131 461832600 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391375 OC1(O)C(=O)c2c(C1=O)c(Br)c(Br)c(Br)c2Br InChI=1S/C9H2Br4O4/c10-3-1-2(4(11)6(13)5(3)12)8(15)9(16,17)7(1)14/h16-17H ZTTWUCSGHUBHMY-UHFFFAOYSA-N 50562209 CHEMBL4798703 Carbonic anhydrase 4 Homo sapiens 39700 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562209&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 184658 461832601 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391376 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51391356 OC1(O)C(=O)c2ccccc2C1=O InChI=1S/C9H6O4/c10-7-5-3-1-2-4-6(5)8(11)9(7,12)13/h1-4,12-13H FEMOMIGRRWSMCU-UHFFFAOYSA-N 50324901 2,2-dihydroxy-1H-indene-1,3(2H)-dione::CHEMBL1221925 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.112875 10.7270/Q2VD735N 33059188 Bouzina, A; Berredjem, M; Nocentini, A; Bua, S; Bouaziz, Z; Jose, J; Le Borgne, M; Marminon, C; Gratteri, P; Supuran, CT Universit£ de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324901&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10236 117646222 CHEMBL1221925 ZINC00388306 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51354000 NS(=O)(=O)c1nnc(NC(=O)C23CC4CC(CC(C4)C2)C3)s1 InChI=1S/C13H18N4O3S2/c14-22(19,20)12-17-16-11(21-12)15-10(18)13-4-7-1-8(5-13)3-9(2-7)6-13/h7-9H,1-6H2,(H2,14,19,20)(H,15,16,18) NBKDQESIWDNDOT-UHFFFAOYSA-N 50547696 CHEMBL1209038 Carbonic anhydrase 4 Homo sapiens 349 ChEMBL 10.1021/acs.jmedchem.0c01390 10.7270/Q2BC435H 33085484 Andring, JT; Fouch, M; Akocak, S; Angeli, A; Supuran, CT; Ilies, MA; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50547696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50547696&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search ARZ 7JOC,3MHC 394897 461678036 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51354001 NS(=O)(=O)c1nnc(NC(=O)C2CCCCC2)s1 InChI=1S/C9H14N4O3S2/c10-18(15,16)9-13-12-8(17-9)11-7(14)6-4-2-1-3-5-6/h6H,1-5H2,(H2,10,15,16)(H,11,12,14) JZWSZGVTKNYBGX-UHFFFAOYSA-N 50547697 CHEMBL4739913 Carbonic anhydrase 4 Homo sapiens 0.360000 ChEMBL 10.1021/acs.jmedchem.0c01390 10.7270/Q2BC435H 33085484 Andring, JT; Fouch, M; Akocak, S; Angeli, A; Supuran, CT; Ilies, MA; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50547697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50547697&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search VGV 8DQF,7JNZ,7JOB 148156817 461678037 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51354002 CC(C)(C)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C7H12N4O3S2/c1-7(2,3)4(12)9-5-10-11-6(15-5)16(8,13)14/h1-3H3,(H2,8,13,14)(H,9,10,12) FNKGYWFCFILCJW-UHFFFAOYSA-N 16668 2,2-dimethyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propanamide::CHEMBL23579::heterocyclic sulfonamide compound 33 Carbonic anhydrase 4 Homo sapiens 0.430000 ChEMBL 10.1021/acs.jmedchem.0c01390 10.7270/Q2BC435H 33085484 Andring, JT; Fouch, M; Akocak, S; Angeli, A; Supuran, CT; Ilies, MA; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16668&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search VGS 7JNX,7JO3 10515762 46516897 CHEMBL23579 ZINC13471993 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51354003 CC(C)C(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C6H10N4O3S2/c1-3(2)4(11)8-5-9-10-6(14-5)15(7,12)13/h3H,1-2H3,(H2,7,12,13)(H,8,9,11) DVZGQBMHOJKRPI-UHFFFAOYSA-N 50331835 5-(2-methyl-propylamido)-2-sulfamoyl-1,3,4-thiadiazole::CHEMBL1288807 Carbonic anhydrase 4 Homo sapiens 0.440000 ChEMBL 10.1021/acs.jmedchem.0c01390 10.7270/Q2BC435H 33085484 Andring, JT; Fouch, M; Akocak, S; Angeli, A; Supuran, CT; Ilies, MA; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331835&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search VFM 7JO2,7JNW 20475140 123110950 CHEMBL1288807 ZINC64573294 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51354004 CCCC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C6H10N4O3S2/c1-2-3-4(11)8-5-9-10-6(14-5)15(7,12)13/h2-3H2,1H3,(H2,7,12,13)(H,8,9,11) HZIYHIRJHYIRQO-UHFFFAOYSA-N 50331834 5-butyramido-2-sulfamoyl-1,3,4-thiadiazole::CHEMBL1288787 Carbonic anhydrase 4 Homo sapiens 0.370000 ChEMBL 10.1021/acs.jmedchem.0c01390 10.7270/Q2BC435H 33085484 Andring, JT; Fouch, M; Akocak, S; Angeli, A; Supuran, CT; Ilies, MA; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331834&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search VFJ 7JNV,7JO1 519309 123110949 CHEMBL1288787 ZINC32150186 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51354005 CCC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C5H8N4O3S2/c1-2-3(10)7-4-8-9-5(13-4)14(6,11)12/h2H2,1H3,(H2,6,11,12)(H,7,8,10) PCBBBQKRWNGNDW-UHFFFAOYSA-N 50331833 5-propylamido-2-sulfamoyl-1,3,4-thiadiazole::CHEMBL1288786 Carbonic anhydrase 4 Homo sapiens 0.780000 ChEMBL 10.1021/acs.jmedchem.0c01390 10.7270/Q2BC435H 33085484 Andring, JT; Fouch, M; Akocak, S; Angeli, A; Supuran, CT; Ilies, MA; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331833&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search VFG 7JNR,7JO0 10354098 123110948 CHEMBL1288786 ZINC04217364 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51354006 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.0c01390 10.7270/Q2BC435H 33085484 Andring, JT; Fouch, M; Akocak, S; Angeli, A; Supuran, CT; Ilies, MA; McKenna, R University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51406108 NS(=O)(=O)c1ccc(C[Te]c2ccccc2)cc1 InChI=1S/C13H13NO2STe/c14-17(15,16)12-8-6-11(7-9-12)10-18-13-4-2-1-3-5-13/h1-9H,10H2,(H2,14,15,16) IADBBIVGFJVNCF-UHFFFAOYSA-N 50511586 CHEMBL4436859 Carbonic anhydrase 4 Homo sapiens 52 ChEMBL 10.1016/j.bmcl.2021.128147 10.7270/Q27S7SJ2 34052322 Angeli, A; Pinteala, M; Maier, SS; Toti, A; Di Cesare Mannelli, L; Ghelardini, C; Selleri, S; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511586&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155512211 440720168 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51406109 Cc1ccc([Te]Cc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C14H15NO2STe/c1-11-2-8-14(9-3-11)19-10-12-4-6-13(7-5-12)18(15,16)17/h2-9H,10H2,1H3,(H2,15,16,17) ARFHGTGKXRNEDW-UHFFFAOYSA-N 50511587 CHEMBL4532721 Carbonic anhydrase 4 Homo sapiens 1.9 ChEMBL 10.1016/j.bmcl.2021.128147 10.7270/Q27S7SJ2 34052322 Angeli, A; Pinteala, M; Maier, SS; Toti, A; Di Cesare Mannelli, L; Ghelardini, C; Selleri, S; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511587&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155547901 440720169 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51406110 COc1ccc([Te]Cc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C14H15NO3STe/c1-18-12-4-8-14(9-5-12)20-10-11-2-6-13(7-3-11)19(15,16)17/h2-9H,10H2,1H3,(H2,15,16,17) CEIMVJWUNWLWTP-UHFFFAOYSA-N 50511588 CHEMBL4453207 Carbonic anhydrase 4 Homo sapiens 2.1 ChEMBL 10.1016/j.bmcl.2021.128147 10.7270/Q27S7SJ2 34052322 Angeli, A; Pinteala, M; Maier, SS; Toti, A; Di Cesare Mannelli, L; Ghelardini, C; Selleri, S; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511588&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155523492 440720170 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51406111 NS(=O)(=O)c1ccc(C[Te]c2ccc3ccccc3c2)cc1 InChI=1S/C17H15NO2STe/c18-21(19,20)16-8-5-13(6-9-16)12-22-17-10-7-14-3-1-2-4-15(14)11-17/h1-11H,12H2,(H2,18,19,20) KMTRVILICSAYCY-UHFFFAOYSA-N 50511589 CHEMBL4482933 Carbonic anhydrase 4 Homo sapiens 828 ChEMBL 10.1016/j.bmcl.2021.128147 10.7270/Q27S7SJ2 34052322 Angeli, A; Pinteala, M; Maier, SS; Toti, A; Di Cesare Mannelli, L; Ghelardini, C; Selleri, S; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511589&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155539989 440720171 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51406112 Cc1ccccc1[Te]Cc1ccc(cc1)S(N)(=O)=O InChI=1S/C14H15NO2STe/c1-11-4-2-3-5-14(11)19-10-12-6-8-13(9-7-12)18(15,16)17/h2-9H,10H2,1H3,(H2,15,16,17) ANUQCVBWDXVQAQ-UHFFFAOYSA-N 50511590 CHEMBL4587627 Carbonic anhydrase 4 Homo sapiens 1.8 ChEMBL 10.1016/j.bmcl.2021.128147 10.7270/Q27S7SJ2 34052322 Angeli, A; Pinteala, M; Maier, SS; Toti, A; Di Cesare Mannelli, L; Ghelardini, C; Selleri, S; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511590&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155566730 440720172 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51406113 Cc1cccc(C)c1[Te]Cc1ccc(cc1)S(N)(=O)=O InChI=1S/C15H17NO2STe/c1-11-4-3-5-12(2)15(11)20-10-13-6-8-14(9-7-13)19(16,17)18/h3-9H,10H2,1-2H3,(H2,16,17,18) NKXDXPNIZYCLCM-UHFFFAOYSA-N 50511591 CHEMBL4453472 Carbonic anhydrase 4 Homo sapiens 5.1 ChEMBL 10.1016/j.bmcl.2021.128147 10.7270/Q27S7SJ2 34052322 Angeli, A; Pinteala, M; Maier, SS; Toti, A; Di Cesare Mannelli, L; Ghelardini, C; Selleri, S; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511591&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155523109 440720173 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51406114 COc1cc([Te]Cc2ccc(cc2)S(N)(=O)=O)cc(OC)c1OC InChI=1S/C16H19NO5STe/c1-20-14-8-13(9-15(21-2)16(14)22-3)24-10-11-4-6-12(7-5-11)23(17,18)19/h4-9H,10H2,1-3H3,(H2,17,18,19) UJOCIUCEXWNXCT-UHFFFAOYSA-N 50511585 CHEMBL4471819 Carbonic anhydrase 4 Homo sapiens 6925 ChEMBL 10.1016/j.bmcl.2021.128147 10.7270/Q27S7SJ2 34052322 Angeli, A; Pinteala, M; Maier, SS; Toti, A; Di Cesare Mannelli, L; Ghelardini, C; Selleri, S; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511585&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155535058 440720167 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51406115 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2021.128147 10.7270/Q27S7SJ2 34052322 Angeli, A; Pinteala, M; Maier, SS; Toti, A; Di Cesare Mannelli, L; Ghelardini, C; Selleri, S; Carta, F; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419973 NS(=O)(=O)c1ccc(cc1)-n1ncc2c1CCCC2=O InChI=1S/C13H13N3O3S/c14-20(18,19)10-6-4-9(5-7-10)16-12-2-1-3-13(17)11(12)8-15-16/h4-8H,1-3H2,(H2,14,18,19) OSAREFJMAAXDHV-UHFFFAOYSA-N 50341397 CHEMBL4176953 Carbonic anhydrase 4 Homo sapiens 9.5 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341397&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145974101 131344333 ZINC71329039 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419974 NS(=O)(=O)c1ccc(cc1)-n1ncc2c1CC(CC2=O)c1ccccc1 InChI=1S/C19H17N3O3S/c20-26(24,25)16-8-6-15(7-9-16)22-18-10-14(13-4-2-1-3-5-13)11-19(23)17(18)12-21-22/h1-9,12,14H,10-11H2,(H2,20,24,25) OPUYATOWSQLHRR-UHFFFAOYSA-N 50341401 CHEMBL4165351 Carbonic anhydrase 4 Homo sapiens 214 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341401&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145952846 131344337 ZINC20661391 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419975 CC1(C)Cc2c(cnn2-c2ccc(cc2)S(N)(=O)=O)C(=O)C1 InChI=1S/C15H17N3O3S/c1-15(2)7-13-12(14(19)8-15)9-17-18(13)10-3-5-11(6-4-10)22(16,20)21/h3-6,9H,7-8H2,1-2H3,(H2,16,20,21) APKGRKWJHXMFDQ-UHFFFAOYSA-N 50341404 CHEMBL4169089 Carbonic anhydrase 4 Homo sapiens 40 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341404&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 145955537 131344340 ZINC71319110 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419976 O=C1CCCc2c1cnn2-c1ccc(cc1)S(=O)(=O)Nc1ccccc1 InChI=1S/C19H17N3O3S/c23-19-8-4-7-18-17(19)13-20-22(18)15-9-11-16(12-10-15)26(24,25)21-14-5-2-1-3-6-14/h1-3,5-6,9-13,21H,4,7-8H2 GPNNPIRKRNAEGF-UHFFFAOYSA-N 50573523 CHEMBL4863724 Carbonic anhydrase 4 Homo sapiens 59600 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573523&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164622171 471063668 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419977 COc1ccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CCCC3=O)cc1 InChI=1S/C20H19N3O4S/c1-27-16-9-5-14(6-10-16)22-28(25,26)17-11-7-15(8-12-17)23-19-3-2-4-20(24)18(19)13-21-23/h5-13,22H,2-4H2,1H3 ISIFNBIDTLWAEC-UHFFFAOYSA-N 50573524 CHEMBL4878097 Carbonic anhydrase 4 Homo sapiens 79300 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573524&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164626870 471063669 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419978 Clc1ccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CCCC3=O)cc1 InChI=1S/C19H16ClN3O3S/c20-13-4-6-14(7-5-13)22-27(25,26)16-10-8-15(9-11-16)23-18-2-1-3-19(24)17(18)12-21-23/h4-12,22H,1-3H2 VNIRWICCNVEOGN-UHFFFAOYSA-N 50573525 CHEMBL4878967 Carbonic anhydrase 4 Homo sapiens 68300 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573525&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164628368 471063670 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419979 [O-][N+](=O)c1ccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CCCC3=O)cc1 InChI=1S/C19H16N4O5S/c24-19-3-1-2-18-17(19)12-20-22(18)14-8-10-16(11-9-14)29(27,28)21-13-4-6-15(7-5-13)23(25)26/h4-12,21H,1-3H2 QTBNOGKZOZCZBN-UHFFFAOYSA-N 50573526 CHEMBL4856807 Carbonic anhydrase 4 Homo sapiens 75800 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573526&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164613046 471063671 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419980 Cc1ccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CCCC3=O)cc1 InChI=1S/C20H19N3O3S/c1-14-5-7-15(8-6-14)22-27(25,26)17-11-9-16(10-12-17)23-19-3-2-4-20(24)18(19)13-21-23/h5-13,22H,2-4H2,1H3 OHFPPMNULPSPPC-UHFFFAOYSA-N 50573527 CHEMBL4863074 Carbonic anhydrase 4 Homo sapiens 52500 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573527&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164623130 471063672 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419981 COc1cccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CCCC3=O)c1 InChI=1S/C20H19N3O4S/c1-27-16-5-2-4-14(12-16)22-28(25,26)17-10-8-15(9-11-17)23-19-6-3-7-20(24)18(19)13-21-23/h2,4-5,8-13,22H,3,6-7H2,1H3 UWFRQVUMZSOHBU-UHFFFAOYSA-N 50573528 CHEMBL4876834 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573528&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164626830 471063673 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419982 Clc1cccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CCCC3=O)c1 InChI=1S/C19H16ClN3O3S/c20-13-3-1-4-14(11-13)22-27(25,26)16-9-7-15(8-10-16)23-18-5-2-6-19(24)17(18)12-21-23/h1,3-4,7-12,22H,2,5-6H2 ZJJNFWVNGQQDTL-UHFFFAOYSA-N 50573529 CHEMBL4867997 Carbonic anhydrase 4 Homo sapiens 55400 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573529&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164623321 471063674 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419983 [O-][N+](=O)c1cccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CCCC3=O)c1 InChI=1S/C19H16N4O5S/c24-19-6-2-5-18-17(19)12-20-22(18)14-7-9-16(10-8-14)29(27,28)21-13-3-1-4-15(11-13)23(25)26/h1,3-4,7-12,21H,2,5-6H2 BZSVTKUPURTAKI-UHFFFAOYSA-N 50573530 CHEMBL4846493 Carbonic anhydrase 4 Homo sapiens 71000 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573530&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164609138 471063675 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419984 Cc1cccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CCCC3=O)c1 InChI=1S/C20H19N3O3S/c1-14-4-2-5-15(12-14)22-27(25,26)17-10-8-16(9-11-17)23-19-6-3-7-20(24)18(19)13-21-23/h2,4-5,8-13,22H,3,6-7H2,1H3 FVIDBQQWZIIBHR-UHFFFAOYSA-N 50573531 CHEMBL4868816 Carbonic anhydrase 4 Homo sapiens 56900 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573531&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164620633 471063676 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419985 O=C1CC(Cc2c1cnn2-c1ccc(cc1)S(=O)(=O)Nc1ccccc1)c1ccccc1 InChI=1S/C25H21N3O3S/c29-25-16-19(18-7-3-1-4-8-18)15-24-23(25)17-26-28(24)21-11-13-22(14-12-21)32(30,31)27-20-9-5-2-6-10-20/h1-14,17,19,27H,15-16H2 CGCKHMRUXGSMGB-UHFFFAOYSA-N 50573532 CHEMBL4847274 Carbonic anhydrase 4 Homo sapiens 83200 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573532&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164615454 471063677 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419986 COc1ccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(CC3=O)c2ccccc2)cc1 InChI=1S/C26H23N3O4S/c1-33-22-11-7-20(8-12-22)28-34(31,32)23-13-9-21(10-14-23)29-25-15-19(18-5-3-2-4-6-18)16-26(30)24(25)17-27-29/h2-14,17,19,28H,15-16H2,1H3 CENUNUSPYZWTSF-UHFFFAOYSA-N 50573533 CHEMBL4873134 Carbonic anhydrase 4 Homo sapiens 62900 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573533&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164624807 471063678 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419987 Clc1ccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(CC3=O)c2ccccc2)cc1 InChI=1S/C25H20ClN3O3S/c26-19-6-8-20(9-7-19)28-33(31,32)22-12-10-21(11-13-22)29-24-14-18(17-4-2-1-3-5-17)15-25(30)23(24)16-27-29/h1-13,16,18,28H,14-15H2 WIOLNEFDVVHGCD-UHFFFAOYSA-N 50573534 CHEMBL4872990 Carbonic anhydrase 4 Homo sapiens 73500 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573534&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164625286 471063679 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419988 [O-][N+](=O)c1ccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(CC3=O)c2ccccc2)cc1 InChI=1S/C25H20N4O5S/c30-25-15-18(17-4-2-1-3-5-17)14-24-23(25)16-26-28(24)20-10-12-22(13-11-20)35(33,34)27-19-6-8-21(9-7-19)29(31)32/h1-13,16,18,27H,14-15H2 PXGLFJMXEWAFQD-UHFFFAOYSA-N 50573535 CHEMBL4861393 Carbonic anhydrase 4 Homo sapiens 930 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573535&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164615330 471063680 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419989 Cc1ccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(CC3=O)c2ccccc2)cc1 InChI=1S/C26H23N3O3S/c1-18-7-9-21(10-8-18)28-33(31,32)23-13-11-22(12-14-23)29-25-15-20(19-5-3-2-4-6-19)16-26(30)24(25)17-27-29/h2-14,17,20,28H,15-16H2,1H3 QTOACEUUFAWSQT-UHFFFAOYSA-N 50573536 CHEMBL4866059 Carbonic anhydrase 4 Homo sapiens 78200 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573536&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164621389 471063681 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419990 COc1cccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(CC3=O)c2ccccc2)c1 InChI=1S/C26H23N3O4S/c1-33-22-9-5-8-20(16-22)28-34(31,32)23-12-10-21(11-13-23)29-25-14-19(18-6-3-2-4-7-18)15-26(30)24(25)17-27-29/h2-13,16-17,19,28H,14-15H2,1H3 XHBPKYNEBVKBBO-UHFFFAOYSA-N 50573537 CHEMBL4862109 Carbonic anhydrase 4 Homo sapiens 87200 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573537&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164618707 471063682 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419991 Clc1cccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(CC3=O)c2ccccc2)c1 InChI=1S/C25H20ClN3O3S/c26-19-7-4-8-20(15-19)28-33(31,32)22-11-9-21(10-12-22)29-24-13-18(17-5-2-1-3-6-17)14-25(30)23(24)16-27-29/h1-12,15-16,18,28H,13-14H2 STNQCWLNJDGHAB-UHFFFAOYSA-N 50573538 CHEMBL4853041 Carbonic anhydrase 4 Homo sapiens 65000 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573538&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164617420 471063683 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419992 [O-][N+](=O)c1cccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(CC3=O)c2ccccc2)c1 InChI=1S/C25H20N4O5S/c30-25-14-18(17-5-2-1-3-6-17)13-24-23(25)16-26-28(24)20-9-11-22(12-10-20)35(33,34)27-19-7-4-8-21(15-19)29(31)32/h1-12,15-16,18,27H,13-14H2 RXYVCWSLLHGPOI-UHFFFAOYSA-N 50573539 CHEMBL4874772 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573539&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164627200 471063684 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419993 Cc1cccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(CC3=O)c2ccccc2)c1 InChI=1S/C26H23N3O3S/c1-18-6-5-9-21(14-18)28-33(31,32)23-12-10-22(11-13-23)29-25-15-20(19-7-3-2-4-8-19)16-26(30)24(25)17-27-29/h2-14,17,20,28H,15-16H2,1H3 HPOOLCARYVSGMV-UHFFFAOYSA-N 50573540 CHEMBL4858530 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573540&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164609912 471063685 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419994 CC1(C)Cc2c(cnn2-c2ccc(cc2)S(=O)(=O)Nc2ccccc2)C(=O)C1 InChI=1S/C21H21N3O3S/c1-21(2)12-19-18(20(25)13-21)14-22-24(19)16-8-10-17(11-9-16)28(26,27)23-15-6-4-3-5-7-15/h3-11,14,23H,12-13H2,1-2H3 WRMMKYXYBZXISR-UHFFFAOYSA-N 50573541 CHEMBL4854220 Carbonic anhydrase 4 Homo sapiens 82100 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573541&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164610726 471063686 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419995 COc1ccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(C)(C)CC3=O)cc1 InChI=1S/C22H23N3O4S/c1-22(2)12-20-19(21(26)13-22)14-23-25(20)16-6-10-18(11-7-16)30(27,28)24-15-4-8-17(29-3)9-5-15/h4-11,14,24H,12-13H2,1-3H3 MAKSDGMHXUTUTP-UHFFFAOYSA-N 50573542 CHEMBL4872434 Carbonic anhydrase 4 Homo sapiens 49700 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573542&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164622529 471063687 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419996 CC1(C)Cc2c(cnn2-c2ccc(cc2)S(=O)(=O)Nc2ccc(Cl)cc2)C(=O)C1 InChI=1S/C21H20ClN3O3S/c1-21(2)11-19-18(20(26)12-21)13-23-25(19)16-7-9-17(10-8-16)29(27,28)24-15-5-3-14(22)4-6-15/h3-10,13,24H,11-12H2,1-2H3 CVFQCGLSPFKYJH-UHFFFAOYSA-N 50573543 CHEMBL4878111 Carbonic anhydrase 4 Homo sapiens 56300 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573543&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164626881 471063688 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419997 CC1(C)Cc2c(cnn2-c2ccc(cc2)S(=O)(=O)Nc2ccc(cc2)[N+]([O-])=O)C(=O)C1 InChI=1S/C21H20N4O5S/c1-21(2)11-19-18(20(26)12-21)13-22-24(19)15-7-9-17(10-8-15)31(29,30)23-14-3-5-16(6-4-14)25(27)28/h3-10,13,23H,11-12H2,1-2H3 IDCUKOHIELLPCZ-UHFFFAOYSA-N 50573544 CHEMBL4850196 Carbonic anhydrase 4 Homo sapiens 74700 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573544&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164618378 471063689 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419998 Cc1ccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(C)(C)CC3=O)cc1 InChI=1S/C22H23N3O3S/c1-15-4-6-16(7-5-15)24-29(27,28)18-10-8-17(9-11-18)25-20-12-22(2,3)13-21(26)19(20)14-23-25/h4-11,14,24H,12-13H2,1-3H3 KBENNVYLBBNWFR-UHFFFAOYSA-N 50573545 CHEMBL4853204 Carbonic anhydrase 4 Homo sapiens 58000 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573545&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164613989 471063690 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51419999 COc1cccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(C)(C)CC3=O)c1 InChI=1S/C22H23N3O4S/c1-22(2)12-20-19(21(26)13-22)14-23-25(20)16-7-9-18(10-8-16)30(27,28)24-15-5-4-6-17(11-15)29-3/h4-11,14,24H,12-13H2,1-3H3 ABVMANFGAWVUCG-UHFFFAOYSA-N 50573546 CHEMBL4858988 Carbonic anhydrase 4 Homo sapiens 47800 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573546&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164615927 471063691 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51420000 CC1(C)Cc2c(cnn2-c2ccc(cc2)S(=O)(=O)Nc2cccc(Cl)c2)C(=O)C1 InChI=1S/C21H20ClN3O3S/c1-21(2)11-19-18(20(26)12-21)13-23-25(19)16-6-8-17(9-7-16)29(27,28)24-15-5-3-4-14(22)10-15/h3-10,13,24H,11-12H2,1-2H3 TZPIMBCRMVMBEE-UHFFFAOYSA-N 50573547 CHEMBL4847208 Carbonic anhydrase 4 Homo sapiens 55700 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573547&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164613217 471063692 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51420001 CC1(C)Cc2c(cnn2-c2ccc(cc2)S(=O)(=O)Nc2cccc(c2)[N+]([O-])=O)C(=O)C1 InChI=1S/C21H20N4O5S/c1-21(2)11-19-18(20(26)12-21)13-22-24(19)15-6-8-17(9-7-15)31(29,30)23-14-4-3-5-16(10-14)25(27)28/h3-10,13,23H,11-12H2,1-2H3 SDJOXDBNECAIAO-UHFFFAOYSA-N 50573548 CHEMBL4861003 Carbonic anhydrase 4 Homo sapiens 92600 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573548&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164614789 471063693 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51420002 Cc1cccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(C)(C)CC3=O)c1 InChI=1S/C22H23N3O3S/c1-15-5-4-6-16(11-15)24-29(27,28)18-9-7-17(8-10-18)25-20-12-22(2,3)13-21(26)19(20)14-23-25/h4-11,14,24H,12-13H2,1-3H3 KCASVXKHFZXGIE-UHFFFAOYSA-N 50573549 CHEMBL4860295 Carbonic anhydrase 4 Homo sapiens 79000 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573549&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164618109 471063694 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51420003 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2021.113490 10.7270/Q2SX6J0Z 33975138 Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S University of Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51413461 CC(=O)n1cc(\C=C2\N=C(N(C2=O)c2ccc(cc2)S(N)(=O)=O)c2ccccc2)c2ccccc12 InChI=1S/C26H20N4O4S/c1-17(31)29-16-19(22-9-5-6-10-24(22)29)15-23-26(32)30(25(28-23)18-7-3-2-4-8-18)20-11-13-21(14-12-20)35(27,33)34/h2-16H,1H3,(H2,27,33,34)/b23-15+ KGTTVEFSCZDNRM-HZHRSRAPSA-N 50570987 CHEMBL4868330 Carbonic anhydrase 4 Homo sapiens 263 ChEMBL 10.1016/j.bmc.2021.116140 10.7270/Q2TM7FWZ 33905966 Buabeng, ER; Henary, M Georgia State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570987&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164620616 471061132 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51413462 CC(=O)NS(=O)(=O)c1ccc(cc1)N1C(=O)\C(=C/c2cn(C(C)=O)c3ccccc23)N=C1c1ccccc1 InChI=1S/C28H22N4O5S/c1-18(33)30-38(36,37)23-14-12-22(13-15-23)32-27(20-8-4-3-5-9-20)29-25(28(32)35)16-21-17-31(19(2)34)26-11-7-6-10-24(21)26/h3-17H,1-2H3,(H,30,33)/b25-16+ BTHVYQLEKGSLEW-PCLIKHOPSA-N 50570988 CHEMBL4863803 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2021.116140 10.7270/Q2TM7FWZ 33905966 Buabeng, ER; Henary, M Georgia State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570988&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164624909 471061133 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51413463 CC(=O)n1cc(\C=C2\N=C(N(C2=O)c2ccc(cc2)S(N)(=O)=O)c2ncccn2)c2ccccc12 InChI=1S/C24H18N6O4S/c1-15(31)29-14-16(19-5-2-3-6-21(19)29)13-20-24(32)30(23(28-20)22-26-11-4-12-27-22)17-7-9-18(10-8-17)35(25,33)34/h2-14H,1H3,(H2,25,33,34)/b20-13+ GUQIGNOAQKOBTM-DEDYPNTBSA-N 50570989 CHEMBL4873646 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2021.116140 10.7270/Q2TM7FWZ 33905966 Buabeng, ER; Henary, M Georgia State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570989&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164620759 471061134 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51413464 COc1ccc(cc1)C1=N\C(=C\c2ccc(O)cc2)C(=O)N1c1ccc(cc1)S(N)(=O)=O InChI=1S/C23H19N3O5S/c1-31-19-10-4-16(5-11-19)22-25-21(14-15-2-8-18(27)9-3-15)23(28)26(22)17-6-12-20(13-7-17)32(24,29)30/h2-14,27H,1H3,(H2,24,29,30)/b21-14+ NYAREIXEICMJFJ-KGENOOAVSA-N 50571001 CHEMBL4872231 Carbonic anhydrase 4 Homo sapiens 6.9 ChEMBL 10.1016/j.bmc.2021.116140 10.7270/Q2TM7FWZ 33905966 Buabeng, ER; Henary, M Georgia State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571001&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164619033 471061146 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51413504 Cc1cc(cc(C)c1S(Cl)(=O)=O)N1CC(CC1=O)C(O)=O InChI=1S/C13H14ClNO5S/c1-7-3-10(4-8(2)12(7)21(14,19)20)15-6-9(13(17)18)5-11(15)16/h3-4,9H,5-6H2,1-2H3,(H,17,18) ZGAMYSVQDGMDNG-UHFFFAOYSA-N 50571007 CHEMBL4439634 Carbonic anhydrase 4 Homo sapiens 0.270000 ChEMBL 10.1016/j.bmc.2021.116140 10.7270/Q2TM7FWZ 33905966 Buabeng, ER; Henary, M Georgia State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50571007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50571007&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155513742 471061152 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51413505 Cc1cc(cc(C)c1S(N)(=O)=O)N1CC(CC1=O)C(O)=O InChI=1S/C13H16N2O5S/c1-7-3-10(4-8(2)12(7)21(14,19)20)15-6-9(13(17)18)5-11(15)16/h3-4,9H,5-6H2,1-2H3,(H,17,18)(H2,14,19,20) LYVVRBXEBODTED-UHFFFAOYSA-N 50503775 CHEMBL4439909 Carbonic anhydrase 4 Homo sapiens 0.270000 ChEMBL 10.1016/j.bmc.2021.116140 10.7270/Q2TM7FWZ 33905966 Buabeng, ER; Henary, M Georgia State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503775&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155514238 440712360 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51413506 Cc1cc(N2CC(CC2=O)C(O)=O)c(Cl)c(C)c1S(N)(=O)=O InChI=1S/C13H15ClN2O5S/c1-6-3-9(11(14)7(2)12(6)22(15,20)21)16-5-8(13(18)19)4-10(16)17/h3,8H,4-5H2,1-2H3,(H,18,19)(H2,15,20,21) PXKOFARYUUHCAL-UHFFFAOYSA-N 50503789 CHEMBL4452277 Carbonic anhydrase 4 Homo sapiens 0.130000 ChEMBL 10.1016/j.bmc.2021.116140 10.7270/Q2TM7FWZ 33905966 Buabeng, ER; Henary, M Georgia State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50503789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50503789&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155522813 440712374 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421291 NS(=O)(=O)c1ccc([Se]CC(O)CSc2ccccc2)cc1 InChI=1S/C15H17NO3S2Se/c16-21(18,19)14-6-8-15(9-7-14)22-11-12(17)10-20-13-4-2-1-3-5-13/h1-9,12,17H,10-11H2,(H2,16,18,19) MMVOFFDQNAVGDE-UHFFFAOYSA-N 50574145 CHEMBL4849345 Carbonic anhydrase 4 Homo sapiens 7.2 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574145&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164617241 471064290 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421292 NS(=O)(=O)c1ccc([Se]CC(O)CSc2ccc(Br)cc2)cc1 InChI=1S/C15H16BrNO3S2Se/c16-11-1-3-13(4-2-11)21-9-12(18)10-23-15-7-5-14(6-8-15)22(17,19)20/h1-8,12,18H,9-10H2,(H2,17,19,20) DJCQETJRQMDDRT-UHFFFAOYSA-N 50574146 CHEMBL4852309 Carbonic anhydrase 4 Homo sapiens 94 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574146&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164612841 471064291 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421293 NS(=O)(=O)c1ccc([Se]CC(O)CSc2ncccn2)cc1 InChI=1S/C13H15N3O3S2Se/c14-21(18,19)11-2-4-12(5-3-11)22-9-10(17)8-20-13-15-6-1-7-16-13/h1-7,10,17H,8-9H2,(H2,14,18,19) LBIZFRBYQYAPDX-UHFFFAOYSA-N 50574147 CHEMBL4868581 Carbonic anhydrase 4 Homo sapiens 71 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574147&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164622353 471064292 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421294 CC(O)CSCC(O)C[Se]c1ccc(cc1)S(N)(=O)=O InChI=1S/C12H19NO4S2Se/c1-9(14)6-18-7-10(15)8-20-12-4-2-11(3-5-12)19(13,16)17/h2-5,9-10,14-15H,6-8H2,1H3,(H2,13,16,17) ZSZQWDGBZAXLBH-UHFFFAOYSA-N 50574148 CHEMBL4862420 Carbonic anhydrase 4 Homo sapiens 517 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574148&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164622123 471064293 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421295 NS(=O)(=O)c1ccc([Se]CC(O)C[Se]c2ccccc2)cc1 InChI=1S/C15H17NO3SSe2/c16-20(18,19)13-6-8-15(9-7-13)22-11-12(17)10-21-14-4-2-1-3-5-14/h1-9,12,17H,10-11H2,(H2,16,18,19) BMFFFZXPNNWEAM-UHFFFAOYSA-N 50574149 CHEMBL4875348 Carbonic anhydrase 4 Homo sapiens 7.5 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574149&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164625930 471064294 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421296 Cc1ccccc1[Se]CC(O)C[Se]c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H19NO3SSe2/c1-12-4-2-3-5-16(12)23-11-13(18)10-22-15-8-6-14(7-9-15)21(17,19)20/h2-9,13,18H,10-11H2,1H3,(H2,17,19,20) AIAHOWZTSKFLIG-UHFFFAOYSA-N 50574150 CHEMBL4848929 Carbonic anhydrase 4 Homo sapiens 90 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574150&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164612704 471064295 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421297 CCCC[Se]CC(O)C[Se]c1ccc(cc1)S(N)(=O)=O InChI=1S/C13H21NO3SSe2/c1-2-3-8-19-9-11(15)10-20-13-6-4-12(5-7-13)18(14,16)17/h4-7,11,15H,2-3,8-10H2,1H3,(H2,14,16,17) OQEKMFRBPRHRCV-UHFFFAOYSA-N 50574151 CHEMBL4874519 Carbonic anhydrase 4 Homo sapiens 6.3 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574151&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search KQU 7ORQ 164626300 471064296 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421298 NS(=O)(=O)c1ccc([Se]CC(O)C[Se]CC(O)COCC=C)cc1 InChI=1S/C15H23NO5SSe2/c1-2-7-21-8-12(17)9-23-10-13(18)11-24-15-5-3-14(4-6-15)22(16,19)20/h2-6,12-13,17-18H,1,7-11H2,(H2,16,19,20) QVSGWSCJAZLDGO-UHFFFAOYSA-N 50574152 CHEMBL4860297 Carbonic anhydrase 4 Homo sapiens 158 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574152&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164618111 471064297 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421299 Cc1ccc([Te]CC(O)C[Se]c2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C16H19NO3SSeTe/c1-12-2-8-16(9-3-12)23-11-13(18)10-22-15-6-4-14(5-7-15)21(17,19)20/h2-9,13,18H,10-11H2,1H3,(H2,17,19,20) KUEXWKPTLXTQDR-UHFFFAOYSA-N 50574153 CHEMBL4865523 Carbonic anhydrase 4 Homo sapiens 43 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574153&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164624555 471064298 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421300 NS(=O)(=O)c1ccc(SCC(O)CSc2ccccc2Br)cc1 InChI=1S/C15H16BrNO3S3/c16-14-3-1-2-4-15(14)22-10-11(18)9-21-12-5-7-13(8-6-12)23(17,19)20/h1-8,11,18H,9-10H2,(H2,17,19,20) PVAZHPAUIJUNRE-UHFFFAOYSA-N 50574154 CHEMBL4861154 Carbonic anhydrase 4 Homo sapiens 751 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574154&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164612609 471064299 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421301 NS(=O)(=O)c1ccc(SCC(O)CSc2cccc(Br)c2)cc1 InChI=1S/C15H16BrNO3S3/c16-11-2-1-3-14(8-11)22-10-12(18)9-21-13-4-6-15(7-5-13)23(17,19)20/h1-8,12,18H,9-10H2,(H2,17,19,20) AZWQLCSAZOZBSM-UHFFFAOYSA-N 50574155 CHEMBL4876604 Carbonic anhydrase 4 Homo sapiens 335 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574155&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164625977 471064300 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421302 C[C@@H](CSCC(O)CSc1ccc(cc1)S(N)(=O)=O)NS(=O)(=O)c1ccc(C)cc1 InChI=1S/C19H26N2O5S4/c1-14-3-7-19(8-4-14)30(25,26)21-15(2)11-27-12-16(22)13-28-17-5-9-18(10-6-17)29(20,23)24/h3-10,15-16,21-22H,11-13H2,1-2H3,(H2,20,23,24)/t15-,16?/m0/s1 WKGYGELJQPBBCV-VYRBHSGPSA-N 50574156 CHEMBL4854070 Carbonic anhydrase 4 Homo sapiens 1365 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574156&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164614560 471064301 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421303 NS(=O)(=O)c1ccc(SCC(O)C[Se]c2ccccc2)cc1 InChI=1S/C15H17NO3S2Se/c16-21(18,19)14-8-6-13(7-9-14)20-10-12(17)11-22-15-4-2-1-3-5-15/h1-9,12,17H,10-11H2,(H2,16,18,19) QKCBBWIKTLMXPY-UHFFFAOYSA-N 50574157 CHEMBL4855451 Carbonic anhydrase 4 Homo sapiens 54 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574157&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search VGT 7OK8 164612972 471064302 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421304 COc1ccc([Se]CC(O)CSc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C16H19NO4S2Se/c1-21-13-2-8-16(9-3-13)24-11-12(18)10-22-14-4-6-15(7-5-14)23(17,19)20/h2-9,12,18H,10-11H2,1H3,(H2,17,19,20) LRGAMVGQJIYFNP-UHFFFAOYSA-N 50574158 CHEMBL4854921 Carbonic anhydrase 4 Homo sapiens 55 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574158&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164611303 471064303 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421305 CCCC[Se]CC(O)CSc1ccc(cc1)S(N)(=O)=O InChI=1S/C13H21NO3S2Se/c1-2-3-8-20-10-11(15)9-18-12-4-6-13(7-5-12)19(14,16)17/h4-7,11,15H,2-3,8-10H2,1H3,(H2,14,16,17) SBKSQUBIMHPBPN-UHFFFAOYSA-N 50574159 CHEMBL4873126 Carbonic anhydrase 4 Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574159&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164624802 471064304 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421306 NS(=O)(=O)c1ccc(SCC(O)C[Se]CC(O)COCC=C)cc1 InChI=1S/C15H23NO5S2Se/c1-2-7-21-8-12(17)10-24-11-13(18)9-22-14-3-5-15(6-4-14)23(16,19)20/h2-6,12-13,17-18H,1,7-11H2,(H2,16,19,20) RHZDWPRIFIBLMT-UHFFFAOYSA-N 50574160 CHEMBL4876272 Carbonic anhydrase 4 Homo sapiens 390 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574160&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164627245 471064305 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421307 COc1cc([Te]CC(O)CSc2ccc(cc2)S(N)(=O)=O)cc(OC)c1OC InChI=1S/C18H23NO6S2Te/c1-23-16-8-15(9-17(24-2)18(16)25-3)28-11-12(20)10-26-13-4-6-14(7-5-13)27(19,21)22/h4-9,12,20H,10-11H2,1-3H3,(H2,19,21,22) RDBLZYXAFPDYEH-UHFFFAOYSA-N 50574161 CHEMBL4873822 Carbonic anhydrase 4 Homo sapiens 3931 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574161&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164624416 471064306 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51421308 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2021.113793 10.7270/Q28S4TRB 34507012 Tanini, D; Carradori, S; Capperucci, A; Lupori, L; Zara, S; Ferraroni, M; Ghelardini, C; Mannelli, L; Micheli, L; Lucarini, E; Carta, F; Angeli, A; Supuran, CT University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432261 OC(=O)c1ccc(N\N=C(\CS(=O)(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 InChI=1S/C21H17ClN2O4S/c22-17-10-6-15(7-11-17)20(14-29(27,28)19-4-2-1-3-5-19)24-23-18-12-8-16(9-13-18)21(25)26/h1-13,23H,14H2,(H,25,26)/b24-20- JUGGQEDMUHVUJO-GFMRDNFCSA-N 50578492 CHEMBL4879069 Carbonic anhydrase 4 Homo sapiens 18070 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578492&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164626418 471054615 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432262 NS(=O)(=O)c1ccc(N\N=C(/C(=O)c2ccccc2)S(=O)(=O)c2ccccc2)cc1 InChI=1S/C20H17N3O5S2/c21-30(27,28)18-13-11-16(12-14-18)22-23-20(19(24)15-7-3-1-4-8-15)29(25,26)17-9-5-2-6-10-17/h1-14,22H,(H2,21,27,28)/b23-20+ BAUMIIPIZWTRRX-BSYVCWPDSA-N 50578493 CHEMBL4852976 Carbonic anhydrase 4 Homo sapiens 2206 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578493&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 10741895 471054616 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432263 OC(=O)c1ccc(N\N=C(/C(=O)c2ccccc2)S(=O)(=O)c2ccccc2)cc1 InChI=1S/C21H16N2O5S/c24-19(15-7-3-1-4-8-15)20(29(27,28)18-9-5-2-6-10-18)23-22-17-13-11-16(12-14-17)21(25)26/h1-14,22H,(H,25,26)/b23-20+ JBVVPUMTKNVKDN-BSYVCWPDSA-N 50578494 CHEMBL4869478 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578494&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164620261 471054617 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432264 NS(=O)(=O)c1ccc(N\C=C(/C(=O)c2ccccc2)S(=O)(=O)c2ccccc2)cc1 InChI=1S/C21H18N2O5S2/c22-30(27,28)19-13-11-17(12-14-19)23-15-20(21(24)16-7-3-1-4-8-16)29(25,26)18-9-5-2-6-10-18/h1-15,23H,(H2,22,27,28)/b20-15+ ROTDUQXCMDMKIU-HMMYKYKNSA-N 50578495 CHEMBL4856651 Carbonic anhydrase 4 Homo sapiens 8381 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578495&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164613033 471054618 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432265 NS(=O)(=O)c1ccc(N\C=C(/C(=O)c2ccc(Br)cc2)S(=O)(=O)c2ccccc2)cc1 InChI=1S/C21H17BrN2O5S2/c22-16-8-6-15(7-9-16)21(25)20(30(26,27)18-4-2-1-3-5-18)14-24-17-10-12-19(13-11-17)31(23,28)29/h1-14,24H,(H2,23,28,29)/b20-14+ HLHBDYSFTOQXJQ-XSFVSMFZSA-N 50578496 CHEMBL4845752 Carbonic anhydrase 4 Homo sapiens 6730 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578496&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164609053 471054619 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432266 NS(=O)(=O)c1ccc(N\C=C(/C(=O)c2ccc(Cl)cc2)S(=O)(=O)c2ccccc2)cc1 InChI=1S/C21H17ClN2O5S2/c22-16-8-6-15(7-9-16)21(25)20(30(26,27)18-4-2-1-3-5-18)14-24-17-10-12-19(13-11-17)31(23,28)29/h1-14,24H,(H2,23,28,29)/b20-14+ SYUBZPVFKHTJLG-XSFVSMFZSA-N 50578497 CHEMBL4846544 Carbonic anhydrase 4 Homo sapiens 6950 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578497&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164609495 471054620 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432267 OC(=O)c1ccc(N\C=C(/C(=O)c2ccccc2)S(=O)(=O)c2ccccc2)cc1 InChI=1S/C22H17NO5S/c24-21(16-7-3-1-4-8-16)20(29(27,28)19-9-5-2-6-10-19)15-23-18-13-11-17(12-14-18)22(25)26/h1-15,23H,(H,25,26)/b20-15+ DPGOLZQNGZZMNY-HMMYKYKNSA-N 50578498 CHEMBL4869222 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578498&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164618913 471054621 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432268 OC(=O)c1ccc(N\C=C(/C(=O)c2ccc(Br)cc2)S(=O)(=O)c2ccccc2)cc1 InChI=1S/C22H16BrNO5S/c23-17-10-6-15(7-11-17)21(25)20(30(28,29)19-4-2-1-3-5-19)14-24-18-12-8-16(9-13-18)22(26)27/h1-14,24H,(H,26,27)/b20-14+ WMIOPMXBAJQACL-XSFVSMFZSA-N 50578499 CHEMBL4864196 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578499&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164619596 471054622 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432269 OC(=O)c1ccc(N\C=C(/C(=O)c2ccc(Cl)cc2)S(=O)(=O)c2ccccc2)cc1 InChI=1S/C22H16ClNO5S/c23-17-10-6-15(7-11-17)21(25)20(30(28,29)19-4-2-1-3-5-19)14-24-18-12-8-16(9-13-18)22(26)27/h1-14,24H,(H,26,27)/b20-14+ WTDSEVJEIZGUJT-XSFVSMFZSA-N 50578500 CHEMBL4873006 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578500&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164624774 471054623 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432270 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432244 NS(=O)(=O)c1ccc(cc1)C(=O)N\N=C(\CS(=O)(=O)c1ccccc1)c1ccccc1 InChI=1S/C21H19N3O5S2/c22-31(28,29)19-13-11-17(12-14-19)21(25)24-23-20(16-7-3-1-4-8-16)15-30(26,27)18-9-5-2-6-10-18/h1-14H,15H2,(H,24,25)(H2,22,28,29)/b23-20- KZASMNJAPQGSMC-ATJXCDBQSA-N 50578475 CHEMBL4852654 Carbonic anhydrase 4 Homo sapiens 575 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578475&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164617407 471054598 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432245 NS(=O)(=O)c1ccc(cc1)C(=O)N\N=C(\CS(=O)(=O)c1ccccc1)c1ccc(Br)cc1 InChI=1S/C21H18BrN3O5S2/c22-17-10-6-15(7-11-17)20(14-31(27,28)18-4-2-1-3-5-18)24-25-21(26)16-8-12-19(13-9-16)32(23,29)30/h1-13H,14H2,(H,25,26)(H2,23,29,30)/b24-20- DXMNNQKTEBVYKD-GFMRDNFCSA-N 50578476 CHEMBL4866949 Carbonic anhydrase 4 Homo sapiens 2289 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578476&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164625639 471054599 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432246 NS(=O)(=O)c1ccc(cc1)C(=O)N\N=C(\CS(=O)(=O)c1ccccc1)c1ccc(Cl)cc1 InChI=1S/C21H18ClN3O5S2/c22-17-10-6-15(7-11-17)20(14-31(27,28)18-4-2-1-3-5-18)24-25-21(26)16-8-12-19(13-9-16)32(23,29)30/h1-13H,14H2,(H,25,26)(H2,23,29,30)/b24-20- RQRNLOFXVRIOQP-GFMRDNFCSA-N 50578477 CHEMBL4852973 Carbonic anhydrase 4 Homo sapiens 1830 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578477&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164614524 471054600 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432247 NS(=O)(=O)c1ccc(cc1)C(=O)N\N=C(\CS(=O)(=O)c1ccccc1)c1ccc(F)cc1 InChI=1S/C21H18FN3O5S2/c22-17-10-6-15(7-11-17)20(14-31(27,28)18-4-2-1-3-5-18)24-25-21(26)16-8-12-19(13-9-16)32(23,29)30/h1-13H,14H2,(H,25,26)(H2,23,29,30)/b24-20- MFSMTAOFCRENAT-GFMRDNFCSA-N 50578478 CHEMBL4855430 Carbonic anhydrase 4 Homo sapiens 766 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578478&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164611319 471054601 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432248 C\C(=N\NC(=O)c1ccc(cc1)S(N)(=O)=O)c1ccccc1 InChI=1S/C15H15N3O3S/c1-11(12-5-3-2-4-6-12)17-18-15(19)13-7-9-14(10-8-13)22(16,20)21/h2-10H,1H3,(H,18,19)(H2,16,20,21)/b17-11- XIURORBNBSCAQM-BOPFTXTBSA-N 50578479 CHEMBL4864894 Carbonic anhydrase 4 Homo sapiens 2936 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578479&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164620042 471054602 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432249 C\C(=N\NC(=O)c1ccc(cc1)S(N)(=O)=O)c1ccc(Br)cc1 InChI=1S/C15H14BrN3O3S/c1-10(11-2-6-13(16)7-3-11)18-19-15(20)12-4-8-14(9-5-12)23(17,21)22/h2-9H,1H3,(H,19,20)(H2,17,21,22)/b18-10- NXBPMCGIKFKXCR-ZDLGFXPLSA-N 50578480 CHEMBL4854779 Carbonic anhydrase 4 Homo sapiens 7991 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578480&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164614596 471054603 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432250 C\C(=N\NC(=O)c1ccc(cc1)S(N)(=O)=O)c1ccc(Cl)cc1 InChI=1S/C15H14ClN3O3S/c1-10(11-2-6-13(16)7-3-11)18-19-15(20)12-4-8-14(9-5-12)23(17,21)22/h2-9H,1H3,(H,19,20)(H2,17,21,22)/b18-10- UNDBDRLDKBHMAK-ZDLGFXPLSA-N 50578481 CHEMBL4848298 Carbonic anhydrase 4 Homo sapiens 8335 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578481&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164618292 471054604 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432251 C\C(=N\NC(=O)c1ccc(cc1)S(N)(=O)=O)c1ccc(F)cc1 InChI=1S/C15H14FN3O3S/c1-10(11-2-6-13(16)7-3-11)18-19-15(20)12-4-8-14(9-5-12)23(17,21)22/h2-9H,1H3,(H,19,20)(H2,17,21,22)/b18-10- XLKGFYZOEWCEPU-ZDLGFXPLSA-N 50578482 CHEMBL4863150 Carbonic anhydrase 4 Homo sapiens 699 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578482&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164624878 471054605 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432252 NS(=O)(=O)c1ccc(cc1)C(=O)N\N=C/c1ccccc1 InChI=1S/C14H13N3O3S/c15-21(19,20)13-8-6-12(7-9-13)14(18)17-16-10-11-4-2-1-3-5-11/h1-10H,(H,17,18)(H2,15,19,20)/b16-10- UCTQYHNHFBXNSN-YBEGLDIGSA-N 50578483 CHEMBL4875764 Carbonic anhydrase 4 Homo sapiens 1974 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578483&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164625943 471054606 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432253 NS(=O)(=O)c1ccc(cc1)C(=O)N\N=C/c1ccc(Br)cc1 InChI=1S/C14H12BrN3O3S/c15-12-5-1-10(2-6-12)9-17-18-14(19)11-3-7-13(8-4-11)22(16,20)21/h1-9H,(H,18,19)(H2,16,20,21)/b17-9- GUMARMMVWUYAHQ-MFOYZWKCSA-N 50578484 CHEMBL4850487 Carbonic anhydrase 4 Homo sapiens 7184 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578484&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164612758 471054607 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432254 NS(=O)(=O)c1ccc(cc1)C(=O)N\N=C/c1ccc(Cl)cc1 InChI=1S/C14H12ClN3O3S/c15-12-5-1-10(2-6-12)9-17-18-14(19)11-3-7-13(8-4-11)22(16,20)21/h1-9H,(H,18,19)(H2,16,20,21)/b17-9- QHPDCMDQHXVCFX-MFOYZWKCSA-N 50578485 CHEMBL4866861 Carbonic anhydrase 4 Homo sapiens 661 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578485&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164623765 471054608 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432255 NS(=O)(=O)c1ccc(cc1)C(=O)N\N=C/c1ccc(F)cc1 InChI=1S/C14H12FN3O3S/c15-12-5-1-10(2-6-12)9-17-18-14(19)11-3-7-13(8-4-11)22(16,20)21/h1-9H,(H,18,19)(H2,16,20,21)/b17-9- SHZTXZZEIYEWMD-MFOYZWKCSA-N 50578486 CHEMBL4854050 Carbonic anhydrase 4 Homo sapiens 158 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578486&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164609632 471054609 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432256 NS(=O)(=O)c1ccc(N\N=C(\CS(=O)(=O)c2ccccc2)c2ccccc2)cc1 InChI=1S/C20H19N3O4S2/c21-29(26,27)19-13-11-17(12-14-19)22-23-20(16-7-3-1-4-8-16)15-28(24,25)18-9-5-2-6-10-18/h1-14,22H,15H2,(H2,21,26,27)/b23-20- SOKBAAUBHYFLBR-ATJXCDBQSA-N 50578487 CHEMBL4853768 Carbonic anhydrase 4 Homo sapiens 97 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578487&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164616849 471054610 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432257 NS(=O)(=O)c1ccc(N\N=C(\CS(=O)(=O)c2ccccc2)c2ccc(Br)cc2)cc1 InChI=1S/C20H18BrN3O4S2/c21-16-8-6-15(7-9-16)20(14-29(25,26)18-4-2-1-3-5-18)24-23-17-10-12-19(13-11-17)30(22,27)28/h1-13,23H,14H2,(H2,22,27,28)/b24-20- KQXLDCJHTCXEGO-GFMRDNFCSA-N 50578488 CHEMBL4874130 Carbonic anhydrase 4 Homo sapiens 8167 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578488&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164626954 471054611 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432258 NS(=O)(=O)c1ccc(N\N=C(\CS(=O)(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 InChI=1S/C20H18ClN3O4S2/c21-16-8-6-15(7-9-16)20(14-29(25,26)18-4-2-1-3-5-18)24-23-17-10-12-19(13-11-17)30(22,27)28/h1-13,23H,14H2,(H2,22,27,28)/b24-20- KKEICQQVQJROGA-GFMRDNFCSA-N 50578489 CHEMBL4856633 Carbonic anhydrase 4 Homo sapiens 8302 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578489&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164611898 471054612 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432259 OC(=O)c1ccc(N\N=C(\CS(=O)(=O)c2ccccc2)c2ccccc2)cc1 InChI=1S/C21H18N2O4S/c24-21(25)17-11-13-18(14-12-17)22-23-20(16-7-3-1-4-8-16)15-28(26,27)19-9-5-2-6-10-19/h1-14,22H,15H2,(H,24,25)/b23-20- IYQUNXKMHBCFKI-ATJXCDBQSA-N 50578490 CHEMBL4866233 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578490&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164620550 471054613 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51432260 OC(=O)c1ccc(N\N=C(\CS(=O)(=O)c2ccccc2)c2ccc(Br)cc2)cc1 InChI=1S/C21H17BrN2O4S/c22-17-10-6-15(7-11-17)20(14-29(27,28)19-4-2-1-3-5-19)24-23-18-12-8-16(9-13-18)21(25)26/h1-13,23H,14H2,(H,25,26)/b24-20- IHRNFMHTWFASRH-GFMRDNFCSA-N 50578491 CHEMBL4850976 Carbonic anhydrase 4 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2021.113486 10.7270/Q2NS0ZRW 33965860 Eldeeb, AH; Abo-Ashour, MF; Angeli, A; Bonardi, A; Lasheen, DS; Elrazaz, EZ; Nocentini, A; Gratteri, P; Abdel-Aziz, HA; Supuran, CT Egyptian Russian University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578491&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 164611174 471054614 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443279 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(Cc2ccccc2)C[C@@H]1CCO InChI=1S/C20H25N3O4S/c21-28(26,27)19-8-6-17(7-9-19)20(25)23-12-11-22(15-18(23)10-13-24)14-16-4-2-1-3-5-16/h1-9,18,24H,10-15H2,(H2,21,26,27)/t18-/m0/s1 UEDHBSMZUFBJAV-SFHVURJKSA-N 50583038 CHEMBL5076279 Carbonic anhydrase 4 Homo sapiens 480 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583038&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 163196361 476028043 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443280 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(Cc2ccccc2)C[C@H]1CCO InChI=1S/C20H25N3O4S/c21-28(26,27)19-8-6-17(7-9-19)20(25)23-12-11-22(15-18(23)10-13-24)14-16-4-2-1-3-5-16/h1-9,18,24H,10-15H2,(H2,21,26,27)/t18-/m1/s1 UEDHBSMZUFBJAV-GOSISDBHSA-N 50583039 CHEMBL5077693 Carbonic anhydrase 4 Homo sapiens 2298 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583039&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 163196362 476028044 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443281 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCNC[C@@H]1CCO InChI=1S/C13H19N3O4S/c14-21(19,20)12-3-1-10(2-4-12)13(18)16-7-6-15-9-11(16)5-8-17/h1-4,11,15,17H,5-9H2,(H2,14,19,20)/t11-/m0/s1 RLNHJHPJFKUJRV-NSHDSACASA-N 50583040 CHEMBL5081522 Carbonic anhydrase 4 Homo sapiens 656 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583040&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 166629522 476028045 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443282 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCNC[C@H]1CCO InChI=1S/C13H19N3O4S/c14-21(19,20)12-3-1-10(2-4-12)13(18)16-7-6-15-9-11(16)5-8-17/h1-4,11,15,17H,5-9H2,(H2,14,19,20)/t11-/m1/s1 RLNHJHPJFKUJRV-LLVKDONJSA-N 50583041 CHEMBL5075094 Carbonic anhydrase 4 Homo sapiens 870 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583041&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 166626385 476028046 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443283 CN1CCN([C@@H](CCO)C1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C14H21N3O4S/c1-16-7-8-17(12(10-16)6-9-18)14(19)11-2-4-13(5-3-11)22(15,20)21/h2-5,12,18H,6-10H2,1H3,(H2,15,20,21)/t12-/m0/s1 WGWWHLAPJDJCKS-LBPRGKRZSA-N 50583042 CHEMBL5079133 Carbonic anhydrase 4 Homo sapiens 751 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583042&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 166628741 476028047 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443284 CN1CCN([C@H](CCO)C1)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C14H21N3O4S/c1-16-7-8-17(12(10-16)6-9-18)14(19)11-2-4-13(5-3-11)22(15,20)21/h2-5,12,18H,6-10H2,1H3,(H2,15,20,21)/t12-/m1/s1 WGWWHLAPJDJCKS-GFCCVEGCSA-N 50583043 CHEMBL5077212 Carbonic anhydrase 4 Homo sapiens 777 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583043&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 166626940 476028048 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443285 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(Cc2ccccc2)C(CCO)C1 InChI=1S/C20H25N3O4S/c21-28(26,27)19-8-6-17(7-9-19)20(25)23-12-11-22(18(15-23)10-13-24)14-16-4-2-1-3-5-16/h1-9,18,24H,10-15H2,(H2,21,26,27) URRVQZIATPXFAS-UHFFFAOYSA-N 50583044 CHEMBL5084609 Carbonic anhydrase 4 Homo sapiens 771 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583044&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 166633137 476028049 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443286 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN(Cc2ccccc2)[C@H](CCO)C1 InChI=1S/C20H25N3O4S/c21-28(26,27)19-8-6-17(7-9-19)20(25)23-12-11-22(18(15-23)10-13-24)14-16-4-2-1-3-5-16/h1-9,18,24H,10-15H2,(H2,21,26,27)/t18-/m1/s1 URRVQZIATPXFAS-GOSISDBHSA-N 50583045 CHEMBL5091121 Carbonic anhydrase 4 Homo sapiens 827 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583045&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 166633717 476028050 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443287 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCNC(CCO)C1 InChI=1S/C13H19N3O4S/c14-21(19,20)12-3-1-10(2-4-12)13(18)16-7-6-15-11(9-16)5-8-17/h1-4,11,15,17H,5-9H2,(H2,14,19,20) ICYLNMSMBLVLBJ-UHFFFAOYSA-N 50583046 CHEMBL5091067 Carbonic anhydrase 4 Homo sapiens 3093 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583046&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 166631469 476028051 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443288 NS(=O)(=O)c1ccc(cc1)C(=O)N1CCN[C@H](CCO)C1 InChI=1S/C13H19N3O4S/c14-21(19,20)12-3-1-10(2-4-12)13(18)16-7-6-15-11(9-16)5-8-17/h1-4,11,15,17H,5-9H2,(H2,14,19,20)/t11-/m1/s1 ICYLNMSMBLVLBJ-LLVKDONJSA-N 50583047 CHEMBL5076302 Carbonic anhydrase 4 Homo sapiens 2778 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583047&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 166627114 476028052 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443289 CN1CCN(CC1CCO)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C14H21N3O4S/c1-16-7-8-17(10-12(16)6-9-18)14(19)11-2-4-13(5-3-11)22(15,20)21/h2-5,12,18H,6-10H2,1H3,(H2,15,20,21) NNVCMAZWDXXBGK-UHFFFAOYSA-N 50583048 CHEMBL5082471 Carbonic anhydrase 4 Homo sapiens 2263 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583048&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 166628624 476028053 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443290 CN1CCN(C[C@H]1CCO)C(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C14H21N3O4S/c1-16-7-8-17(10-12(16)6-9-18)14(19)11-2-4-13(5-3-11)22(15,20)21/h2-5,12,18H,6-10H2,1H3,(H2,15,20,21)/t12-/m1/s1 NNVCMAZWDXXBGK-GFCCVEGCSA-N 50583049 CHEMBL5083157 Carbonic anhydrase 4 Homo sapiens 2798 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583049&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 166629378 476028054 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51443291 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2021.114026 10.7270/Q2X06BZZ 34920169 Chiaramonte, N; Angeli, A; Sgambellone, S; Bonardi, A; Nocentini, A; Bartolucci, G; Braconi, L; Dei, S; Lucarini, L; Teodori, E; Gratteri, P; Wünsch, B; Supuran, CT; Romanelli, MN University of Florence http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465291 Cl.NS(=O)(=O)c1ccc(OCCNCC2COc3ccccc3O2)cc1 InChI=1S/C17H20N2O5S.ClH/c18-25(20,21)15-7-5-13(6-8-15)22-10-9-19-11-14-12-23-16-3-1-2-4-17(16)24-14;/h1-8,14,19H,9-12H2,(H2,18,20,21);1H DSIDRCLLZRECGD-UHFFFAOYSA-N 50591297 CHEMBL5171860 Carbonic anhydrase 4 Homo sapiens 291 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591297&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168270594 482602149 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465292 Cl.CNS(=O)(=O)c1ccc(OCCNCC2COc3ccccc3O2)cc1 InChI=1S/C18H22N2O5S.ClH/c1-19-26(21,22)16-8-6-14(7-9-16)23-11-10-20-12-15-13-24-17-4-2-3-5-18(17)25-15;/h2-9,15,19-20H,10-13H2,1H3;1H ANFYGBIYXQAXBW-UHFFFAOYSA-N 50591298 CHEMBL5201114 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591298&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168290870 482602150 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465293 Cl.CCNS(=O)(=O)c1ccc(OCCNCC2COc3ccccc3O2)cc1 InChI=1S/C19H24N2O5S.ClH/c1-2-21-27(22,23)17-9-7-15(8-10-17)24-12-11-20-13-16-14-25-18-5-3-4-6-19(18)26-16;/h3-10,16,20-21H,2,11-14H2,1H3;1H QPGIWEPLOILZSJ-UHFFFAOYSA-N 50591299 CHEMBL5191609 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591299&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168285281 482602151 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465294 Cl.CN(C)S(=O)(=O)c1ccc(OCCNCC2COc3ccccc3O2)cc1 InChI=1S/C19H24N2O5S.ClH/c1-21(2)27(22,23)17-9-7-15(8-10-17)24-12-11-20-13-16-14-25-18-5-3-4-6-19(18)26-16;/h3-10,16,20H,11-14H2,1-2H3;1H ZLVODBUBXKSGHQ-UHFFFAOYSA-N 50591300 CHEMBL5193118 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591300&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168289174 482602152 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465295 Cl.CC(C)S(=O)(=O)Nc1ccc(OCCNCC2COc3ccccc3O2)cc1 InChI=1S/C20H26N2O5S.ClH/c1-15(2)28(23,24)22-16-7-9-17(10-8-16)25-12-11-21-13-18-14-26-19-5-3-4-6-20(19)27-18;/h3-10,15,18,21-22H,11-14H2,1-2H3;1H ABMMNRTWEULQKF-UHFFFAOYSA-N 50591301 CHEMBL5184240 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591301&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168279154 482602153 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465296 Cl.CS(=O)(=O)Nc1ccc(OCCNCC2COc3ccccc3O2)cc1 InChI=1S/C18H22N2O5S.ClH/c1-26(21,22)20-14-6-8-15(9-7-14)23-11-10-19-12-16-13-24-17-4-2-3-5-18(17)25-16;/h2-9,16,19-20H,10-13H2,1H3;1H PWVWGAOSSSTXJF-UHFFFAOYSA-N 50591302 CHEMBL5194237 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591302&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168287065 482602154 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465297 Cl.CCS(=O)(=O)Nc1ccc(OCCNCC2COc3ccccc3O2)cc1 InChI=1S/C19H24N2O5S.ClH/c1-2-27(22,23)21-15-7-9-16(10-8-15)24-12-11-20-13-17-14-25-18-5-3-4-6-19(18)26-17;/h3-10,17,20-21H,2,11-14H2,1H3;1H QYMWDYNNAYSCKX-UHFFFAOYSA-N 50591303 CHEMBL5203377 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591303&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168292789 482602155 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465298 Cl.CC(C)CS(=O)(=O)Nc1ccc(OCCNCC2COc3ccccc3O2)cc1 InChI=1S/C21H28N2O5S.ClH/c1-16(2)15-29(24,25)23-17-7-9-18(10-8-17)26-12-11-22-13-19-14-27-20-5-3-4-6-21(20)28-19;/h3-10,16,19,22-23H,11-15H2,1-2H3;1H ZLEDZLCBOQTLOU-UHFFFAOYSA-N 50591304 CHEMBL5176469 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591304&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168274113 482602156 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465299 NS(=O)(=O)c1ccc(OCCC(N=[N+]=[N-])C2COc3ccccc3O2)cc1 InChI=1S/C17H18N4O5S/c18-21-20-14(17-11-25-15-3-1-2-4-16(15)26-17)9-10-24-12-5-7-13(8-6-12)27(19,22)23/h1-8,14,17H,9-11H2,(H2,19,22,23) PDRSXISLBNGOBW-UHFFFAOYSA-N 50591305 CHEMBL5191973 Carbonic anhydrase 4 Homo sapiens 4551 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591305&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168286950 482602157 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465300 COc1cc(ccc1OCCC(N=[N+]=[N-])C1COc2ccccc2O1)S(N)(=O)=O InChI=1S/C18H20N4O6S/c1-25-17-10-12(29(20,23)24)6-7-15(17)26-9-8-13(21-22-19)18-11-27-14-4-2-3-5-16(14)28-18/h2-7,10,13,18H,8-9,11H2,1H3,(H2,20,23,24) ICGMHRGRBDFTOT-UHFFFAOYSA-N 50591306 CHEMBL5206696 Carbonic anhydrase 4 Homo sapiens 6144 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591306&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168294601 482602158 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465301 COc1cc(cc(OC)c1OCCC(N=[N+]=[N-])C1COc2ccccc2O1)S(N)(=O)=O InChI=1S/C19H22N4O7S/c1-26-16-9-12(31(21,24)25)10-17(27-2)19(16)28-8-7-13(22-23-20)18-11-29-14-5-3-4-6-15(14)30-18/h3-6,9-10,13,18H,7-8,11H2,1-2H3,(H2,21,24,25) LAAJQZRMLUJAGE-UHFFFAOYSA-N 50591307 CHEMBL5198237 Carbonic anhydrase 4 Homo sapiens 4564 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591307&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168289387 482602159 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465302 NC(CCOc1ccc(cc1)S(N)(=O)=O)C1COc2ccccc2O1 InChI=1S/C17H20N2O5S/c18-14(17-11-23-15-3-1-2-4-16(15)24-17)9-10-22-12-5-7-13(8-6-12)25(19,20)21/h1-8,14,17H,9-11,18H2,(H2,19,20,21) GHVPEVBTYVRTHA-UHFFFAOYSA-N 50591308 CHEMBL5177166 Carbonic anhydrase 4 Homo sapiens 3034 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591308&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 165413025 482602160 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465303 COc1cc(ccc1OCCC(N)C1COc2ccccc2O1)S(N)(=O)=O InChI=1S/C18H22N2O6S/c1-23-17-10-12(27(20,21)22)6-7-15(17)24-9-8-13(19)18-11-25-14-4-2-3-5-16(14)26-18/h2-7,10,13,18H,8-9,11,19H2,1H3,(H2,20,21,22) KOIYEFLKONFTEX-UHFFFAOYSA-N 50591309 CHEMBL5193531 Carbonic anhydrase 4 Homo sapiens 478 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591309&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168287430 482602161 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465304 COc1cc(cc(OC)c1OCCC(N)C1COc2ccccc2O1)S(N)(=O)=O InChI=1S/C19H24N2O7S/c1-24-16-9-12(29(21,22)23)10-17(25-2)19(16)26-8-7-13(20)18-11-27-14-5-3-4-6-15(14)28-18/h3-6,9-10,13,18H,7-8,11,20H2,1-2H3,(H2,21,22,23) RUMNOCQXRVXQHH-UHFFFAOYSA-N 50591310 CHEMBL5205289 Carbonic anhydrase 4 Homo sapiens 4840 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591310&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168295343 482602162 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465305 COc1cccc(OC)c1OCCNCC1COc2ccccc2O1 InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3 GYSZUJHYXCZAKI-UHFFFAOYSA-N 69602 2,3-dihydro-1,4-benzodioxin-3-ylmethyl-[2-(2,6-dimethoxyphenoxy)ethyl]amine;hydrochloride::CHEMBL25554::MLS000859914::N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine;hydrochloride::SMR000326775::WB-4101::WB-4101 hydrochloride::cid_11957505 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=69602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=69602&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 5685 252647768 64094 CHEMBL25554 ZINC02169424 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465306 N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1F InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1 MFFMDFFZMYYVKS-SECBINFHSA-N 11162 (1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorobenzyl)propylamine::(3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[3,4-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride::CHEMBL393336::MK-0431::Sitagliptin::Sitagliptin (13)::Triazolopiperazine Analogue 1::US10479798, Compound MK0431 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11162&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 715 1X70,4FFW 4369359 46511716 CHEMBL393336 DB01261 ZINC01489478 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51465307 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.7270/Q2PG1WQ6 36201615 Artasensi, A; Angeli, A; Lammi, C; Bollati, C; Gervasoni, S; Baron, G; Matucci, R; Supuran, CT; Vistoli, G; Fumagalli, L Universit£ degli Studi di Milano http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461599 NS(=O)(=O)c1ccc(CCN(Cc2ccccc2)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C25H22N2O3S4/c26-34(29,30)22-12-6-18(7-13-22)14-15-27(16-19-4-2-1-3-5-19)24(28)21-10-8-20(9-11-21)23-17-32-33-25(23)31/h1-13,17H,14-16H2,(H2,26,29,30) RDEONVCPWYDGHQ-UHFFFAOYSA-N 50589807 CHEMBL5208878 Carbonic anhydrase 4 Homo sapiens 4339 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589807&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168294397 482600659 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461600 NS(=O)(=O)c1ccc(CCN(Cc2ccc(F)cc2)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C25H21FN2O3S4/c26-21-9-1-18(2-10-21)15-28(14-13-17-3-11-22(12-4-17)35(27,30)31)24(29)20-7-5-19(6-8-20)23-16-33-34-25(23)32/h1-12,16H,13-15H2,(H2,27,30,31) UTQJRWNAFMCXIW-UHFFFAOYSA-N 50589808 CHEMBL5197140 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589808&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168285586 482600660 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461601 NS(=O)(=O)c1ccc(CCN(Cc2ccc(Cl)cc2)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C25H21ClN2O3S4/c26-21-9-1-18(2-10-21)15-28(14-13-17-3-11-22(12-4-17)35(27,30)31)24(29)20-7-5-19(6-8-20)23-16-33-34-25(23)32/h1-12,16H,13-15H2,(H2,27,30,31) VCZXSLHRLYRBBW-UHFFFAOYSA-N 50589809 CHEMBL5178653 Carbonic anhydrase 4 Homo sapiens 430 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589809&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168273753 482600661 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461602 NS(=O)(=O)c1ccc(CCN(Cc2ccc(Br)cc2)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C25H21BrN2O3S4/c26-21-9-1-18(2-10-21)15-28(14-13-17-3-11-22(12-4-17)35(27,30)31)24(29)20-7-5-19(6-8-20)23-16-33-34-25(23)32/h1-12,16H,13-15H2,(H2,27,30,31) INTKVLJQJDWIIT-UHFFFAOYSA-N 50589810 CHEMBL5181123 Carbonic anhydrase 4 Homo sapiens 1042 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589810&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168275991 482600662 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461603 NS(=O)(=O)c1ccc(CCN(Cc2ccc(cc2)C#N)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C26H21N3O3S4/c27-15-19-1-3-20(4-2-19)16-29(14-13-18-5-11-23(12-6-18)36(28,31)32)25(30)22-9-7-21(8-10-22)24-17-34-35-26(24)33/h1-12,17H,13-14,16H2,(H2,28,31,32) KVHZYPAKMFWHKV-UHFFFAOYSA-N 50589811 CHEMBL5198090 Carbonic anhydrase 4 Homo sapiens 46 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589811&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168289563 482600663 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461604 CN(C)c1ccc(CN(CCc2ccc(cc2)S(N)(=O)=O)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C27H27N3O3S4/c1-29(2)23-11-3-20(4-12-23)17-30(16-15-19-5-13-24(14-6-19)37(28,32)33)26(31)22-9-7-21(8-10-22)25-18-35-36-27(25)34/h3-14,18H,15-17H2,1-2H3,(H2,28,32,33) AZUWFCOATFJDOY-UHFFFAOYSA-N 50589812 CHEMBL5199724 Carbonic anhydrase 4 Homo sapiens 3412 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589812&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168290496 482600664 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461605 NS(=O)(=O)c1ccc(CCN(Cc2ccc(cc2)[N+]([O-])=O)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C25H21N3O5S4/c26-37(32,33)22-11-3-17(4-12-22)13-14-27(15-18-1-9-21(10-2-18)28(30)31)24(29)20-7-5-19(6-8-20)23-16-35-36-25(23)34/h1-12,16H,13-15H2,(H2,26,32,33) ACYMQSHNTGPRFH-UHFFFAOYSA-N 50589813 CHEMBL5196450 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589813&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168285923 482600665 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461606 COc1cc(ccc1CN(CCc1ccc(cc1)S(N)(=O)=O)C(=O)c1ccc(cc1)-c1cssc1=S)[N+]([O-])=O InChI=1S/C26H23N3O6S4/c1-35-24-14-21(29(31)32)9-8-20(24)15-28(13-12-17-2-10-22(11-3-17)39(27,33)34)25(30)19-6-4-18(5-7-19)23-16-37-38-26(23)36/h2-11,14,16H,12-13,15H2,1H3,(H2,27,33,34) KZSGDXTWOYBDNP-UHFFFAOYSA-N 50589814 CHEMBL5172583 Carbonic anhydrase 4 Homo sapiens 4093 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589814&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 165412817 482600666 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461607 COc1ccc(CN(CCc2ccc(cc2)S(N)(=O)=O)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C26H24N2O4S4/c1-32-22-10-2-19(3-11-22)16-28(15-14-18-4-12-23(13-5-18)36(27,30)31)25(29)21-8-6-20(7-9-21)24-17-34-35-26(24)33/h2-13,17H,14-16H2,1H3,(H2,27,30,31) LZBGRORDASXWIU-UHFFFAOYSA-N 50589815 CHEMBL5197606 Carbonic anhydrase 4 Homo sapiens 1586 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589815&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168285611 482600667 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461608 COc1ccc(CN(CCc2ccc(cc2)S(N)(=O)=O)C(=O)c2ccc(cc2)-c2cssc2=S)cc1OC InChI=1S/C27H26N2O5S4/c1-33-24-12-5-19(15-25(24)34-2)16-29(14-13-18-3-10-22(11-4-18)38(28,31)32)26(30)21-8-6-20(7-9-21)23-17-36-37-27(23)35/h3-12,15,17H,13-14,16H2,1-2H3,(H2,28,31,32) JLKHBMWSIKCZJQ-UHFFFAOYSA-N 50589816 CHEMBL5205077 Carbonic anhydrase 4 Homo sapiens 293 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589816&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168297791 482600668 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461609 CSc1ccc(CN(CCc2ccc(cc2)S(N)(=O)=O)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C26H24N2O3S5/c1-33-22-10-2-19(3-11-22)16-28(15-14-18-4-12-23(13-5-18)36(27,30)31)25(29)21-8-6-20(7-9-21)24-17-34-35-26(24)32/h2-13,17H,14-16H2,1H3,(H2,27,30,31) IKCSRQYZULOBDX-UHFFFAOYSA-N 50589817 CHEMBL5193063 Carbonic anhydrase 4 Homo sapiens 404 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589817&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168287410 482600669 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461610 NS(=O)(=O)c1ccc(CCN(Cc2cccc3ccccc23)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C29H24N2O3S4/c30-38(33,34)25-14-8-20(9-15-25)16-17-31(18-24-6-3-5-21-4-1-2-7-26(21)24)28(32)23-12-10-22(11-13-23)27-19-36-37-29(27)35/h1-15,19H,16-18H2,(H2,30,33,34) LXJKCTXIMVDZAI-UHFFFAOYSA-N 50589818 CHEMBL5182919 Carbonic anhydrase 4 Homo sapiens 244 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589818&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168279491 482600670 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461611 NS(=O)(=O)c1ccc(CCN(Cc2csc3ccccc23)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C27H22N2O3S5/c28-37(31,32)22-11-5-18(6-12-22)13-14-29(15-21-16-34-25-4-2-1-3-23(21)25)26(30)20-9-7-19(8-10-20)24-17-35-36-27(24)33/h1-12,16-17H,13-15H2,(H2,28,31,32) ZMSGRMUQJXTESS-UHFFFAOYSA-N 50589819 CHEMBL5182563 Carbonic anhydrase 4 Homo sapiens 48 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589819&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168278420 482600671 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461612 NS(=O)(=O)c1ccc(CCN(CCc2ccccc2)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C26H24N2O3S4/c27-35(30,31)23-12-6-20(7-13-23)15-17-28(16-14-19-4-2-1-3-5-19)25(29)22-10-8-21(9-11-22)24-18-33-34-26(24)32/h1-13,18H,14-17H2,(H2,27,30,31) QSBZUGMJVVHFGY-UHFFFAOYSA-N 50589820 CHEMBL5190174 Carbonic anhydrase 4 Homo sapiens 243 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589820&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168283986 482600672 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461613 NS(=O)(=O)c1ccc(CCN(CCC#N)C(=O)c2ccc(cc2)-c2cssc2=S)cc1 InChI=1S/C21H19N3O3S4/c22-11-1-12-24(13-10-15-2-8-18(9-3-15)31(23,26)27)20(25)17-6-4-16(5-7-17)19-14-29-30-21(19)28/h2-9,14H,1,10,12-13H2,(H2,23,26,27) GXKNLZFRRKFQCC-UHFFFAOYSA-N 50589821 CHEMBL5190396 Carbonic anhydrase 4 Homo sapiens 523 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589821&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168284082 482600673 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461614 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461615 NS(=O)(=O)c1ccc(CCNCc2ccc(Cl)cc2)cc1 InChI=1S/C15H17ClN2O2S/c16-14-5-1-13(2-6-14)11-18-10-9-12-3-7-15(8-4-12)21(17,19)20/h1-8,18H,9-11H2,(H2,17,19,20) OEVYSRGAVMIHLR-UHFFFAOYSA-N 50589822 CHEMBL5207894 Carbonic anhydrase 4 Homo sapiens 0.900000 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589822&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4722330 482600674 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461616 NS(=O)(=O)c1ccc(CCNCc2ccc(Br)cc2)cc1 InChI=1S/C15H17BrN2O2S/c16-14-5-1-13(2-6-14)11-18-10-9-12-3-7-15(8-4-12)21(17,19)20/h1-8,18H,9-11H2,(H2,17,19,20) KLZURSWNFBVOBU-UHFFFAOYSA-N 50589823 CHEMBL5199926 Carbonic anhydrase 4 Homo sapiens 0.900000 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589823&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4718094 482600675 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461617 NS(=O)(=O)c1ccc(CCNCc2ccc(cc2)C#N)cc1 InChI=1S/C16H17N3O2S/c17-11-14-1-3-15(4-2-14)12-19-10-9-13-5-7-16(8-6-13)22(18,20)21/h1-8,19H,9-10,12H2,(H2,18,20,21) RJOWJTOQJWFHJI-UHFFFAOYSA-N 50589824 CHEMBL5177103 Carbonic anhydrase 4 Homo sapiens 0.900000 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589824&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168273662 482600676 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461618 CN(C)c1ccc(CNCCc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C17H23N3O2S/c1-20(2)16-7-3-15(4-8-16)13-19-12-11-14-5-9-17(10-6-14)23(18,21)22/h3-10,19H,11-13H2,1-2H3,(H2,18,21,22) GAFHFMSHSNKQDR-UHFFFAOYSA-N 50082759 CHEMBL3423268 Carbonic anhydrase 4 Homo sapiens 0.900000 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082759&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4723880 313074579 CHEMBL3423268 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461619 COc1cc(ccc1CNCCc1ccc(cc1)S(N)(=O)=O)[N+]([O-])=O InChI=1S/C16H19N3O5S/c1-24-16-10-14(19(20)21)5-4-13(16)11-18-9-8-12-2-6-15(7-3-12)25(17,22)23/h2-7,10,18H,8-9,11H2,1H3,(H2,17,22,23) MKSMWLWYNATSCV-UHFFFAOYSA-N 50589825 CHEMBL5193273 Carbonic anhydrase 4 Homo sapiens 0.900000 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589825&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168284619 482600677 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461620 COc1ccc(CNCCc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C16H20N2O3S/c1-21-15-6-2-14(3-7-15)12-18-11-10-13-4-8-16(9-5-13)22(17,19)20/h2-9,18H,10-12H2,1H3,(H2,17,19,20) DJIQHQYIPAYBKR-UHFFFAOYSA-N 50082763 CHEMBL3423262 Carbonic anhydrase 4 Homo sapiens 0.900000 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50082763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50082763&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4718971 313074583 CHEMBL3423262 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461621 COc1ccc(CNCCc2ccc(cc2)S(N)(=O)=O)cc1OC InChI=1S/C17H22N2O4S/c1-22-16-8-5-14(11-17(16)23-2)12-19-10-9-13-3-6-15(7-4-13)24(18,20)21/h3-8,11,19H,9-10,12H2,1-2H3,(H2,18,20,21) TZCPALNCOZRZIG-UHFFFAOYSA-N 50589826 CHEMBL5183301 Carbonic anhydrase 4 Homo sapiens 0.900000 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589826&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4722332 482600678 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461622 CSc1ccc(CNCCc2ccc(cc2)S(N)(=O)=O)cc1 InChI=1S/C16H20N2O2S2/c1-21-15-6-2-14(3-7-15)12-18-11-10-13-4-8-16(9-5-13)22(17,19)20/h2-9,18H,10-12H2,1H3,(H2,17,19,20) JUBMILSSQMNPKL-UHFFFAOYSA-N 50589827 CHEMBL5192003 Carbonic anhydrase 4 Homo sapiens 0.900000 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589827&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4719675 482600679 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461623 NS(=O)(=O)c1ccc(CCNCc2cccc3ccccc23)cc1 InChI=1S/C19H20N2O2S/c20-24(22,23)18-10-8-15(9-11-18)12-13-21-14-17-6-3-5-16-4-1-2-7-19(16)17/h1-11,21H,12-14H2,(H2,20,22,23) VXZRQQMOCBAJCN-UHFFFAOYSA-N 50004997 CHEMBL2392427 Carbonic anhydrase 4 Homo sapiens 0.900000 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50004997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50004997&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 4718107 103918544 CHEMBL2392427 ZINC13455144 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51461624 NS(=O)(=O)c1ccc(CCNCc2csc3ccccc23)cc1 InChI=1S/C17H18N2O2S2/c18-23(20,21)15-7-5-13(6-8-15)9-10-19-11-14-12-22-17-4-2-1-3-16(14)17/h1-8,12,19H,9-11H2,(H2,18,20,21) KAQRASNRSBSXMM-UHFFFAOYSA-N 50589828 CHEMBL5197745 Carbonic anhydrase 4 Homo sapiens 0.900000 ChEMBL 10.7270/Q2DN491K 36121705 Bonardi, A; Micheli, L; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Nocentini, A; Supuran, CT University of Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589828&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168288549 482600680 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459663 NS(=O)(=O)c1cccc(N\C=C\C(=O)c2ccccc2)c1 InChI=1S/C15H14N2O3S/c16-21(19,20)14-8-4-7-13(11-14)17-10-9-15(18)12-5-2-1-3-6-12/h1-11,17H,(H2,16,19,20)/b10-9+ AGXGYDAEKDOFPV-MDZDMXLPSA-N 50588949 CHEMBL5177824 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588949&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168271206 482599801 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459664 NS(=O)(=O)c1cccc(N\C=C\C(=O)c2ccc(Cl)cc2)c1 InChI=1S/C15H13ClN2O3S/c16-12-6-4-11(5-7-12)15(19)8-9-18-13-2-1-3-14(10-13)22(17,20)21/h1-10,18H,(H2,17,20,21)/b9-8+ CDNDGWRDBIEZRJ-CMDGGOBGSA-N 50588950 CHEMBL5202849 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588950&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168293610 482599802 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459665 NS(=O)(=O)c1cccc(N\C=C\C(=O)c2ccc(Br)cc2)c1 InChI=1S/C15H13BrN2O3S/c16-12-6-4-11(5-7-12)15(19)8-9-18-13-2-1-3-14(10-13)22(17,20)21/h1-10,18H,(H2,17,20,21)/b9-8+ FPIFZCNDELXVOF-CMDGGOBGSA-N 50588951 CHEMBL5183882 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588951&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168284154 482599803 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459666 Cc1ccc(cc1)C(=O)\C=C\Nc1cccc(c1)S(N)(=O)=O InChI=1S/C16H16N2O3S/c1-12-5-7-13(8-6-12)16(19)9-10-18-14-3-2-4-15(11-14)22(17,20)21/h2-11,18H,1H3,(H2,17,20,21)/b10-9+ OJTKHYDQGCGNAT-MDZDMXLPSA-N 50588952 CHEMBL5171339 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588952&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168269012 482599804 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459667 COc1ccc(cc1)C(=O)\C=C\Nc1cccc(c1)S(N)(=O)=O InChI=1S/C16H16N2O4S/c1-22-14-7-5-12(6-8-14)16(19)9-10-18-13-3-2-4-15(11-13)23(17,20)21/h2-11,18H,1H3,(H2,17,20,21)/b10-9+ AMWZZZNJPIGOGE-MDZDMXLPSA-N 50588953 CHEMBL5176844 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588953&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168276560 482599805 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459668 NS(=O)(=O)c1cccc(N\C=C\C(=O)c2ccc(cc2)[N+]([O-])=O)c1 InChI=1S/C15H13N3O5S/c16-24(22,23)14-3-1-2-12(10-14)17-9-8-15(19)11-4-6-13(7-5-11)18(20)21/h1-10,17H,(H2,16,22,23)/b9-8+ JLNSNXWIZOYTBT-CMDGGOBGSA-N 50588954 CHEMBL5189073 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588954&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168278371 482599806 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459669 NS(=O)(=O)c1cccc(N\C=C\C(=O)c2ccc3ccccc3c2)c1 InChI=1S/C19H16N2O3S/c20-25(23,24)18-7-3-6-17(13-18)21-11-10-19(22)16-9-8-14-4-1-2-5-15(14)12-16/h1-13,21H,(H2,20,23,24)/b11-10+ PRNZLOBIWWOPMA-ZHACJKMWSA-N 50588955 CHEMBL5183127 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588955&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168281689 482599807 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459670 NS(=O)(=O)c1cccc(N\C=C\C(=O)c2ccco2)c1 InChI=1S/C13H12N2O4S/c14-20(17,18)11-4-1-3-10(9-11)15-7-6-12(16)13-5-2-8-19-13/h1-9,15H,(H2,14,17,18)/b7-6+ WJAUMHGOQJPXBU-VOTSOKGWSA-N 50588956 CHEMBL5209225 Carbonic anhydrase 4 Homo sapiens 65 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588956&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168294418 482599808 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459671 NS(=O)(=O)c1cccc(N\C=C\C(=O)c2cccs2)c1 InChI=1S/C13H12N2O3S2/c14-20(17,18)11-4-1-3-10(9-11)15-7-6-12(16)13-5-2-8-19-13/h1-9,15H,(H2,14,17,18)/b7-6+ BVANFFKUMNJMFK-VOTSOKGWSA-N 50588957 CHEMBL5195990 Carbonic anhydrase 4 Homo sapiens 8.7 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588957&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168286735 482599809 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459672 NS(=O)(=O)c1ccc(N\C=C\C(=O)c2ccccc2)cc1 InChI=1S/C15H14N2O3S/c16-21(19,20)14-8-6-13(7-9-14)17-11-10-15(18)12-4-2-1-3-5-12/h1-11,17H,(H2,16,19,20)/b11-10+ RQYZWBKWFKVNDK-ZHACJKMWSA-N 50588958 CHEMBL5180852 Carbonic anhydrase 4 Homo sapiens 22 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588958&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2189650 482599810 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459673 NS(=O)(=O)c1ccc(N\C=C\C(=O)c2ccc(F)cc2)cc1 InChI=1S/C15H13FN2O3S/c16-12-3-1-11(2-4-12)15(19)9-10-18-13-5-7-14(8-6-13)22(17,20)21/h1-10,18H,(H2,17,20,21)/b10-9+ JKAUEJKKIQTCJJ-MDZDMXLPSA-N 50588959 CHEMBL5192495 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588959&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2254478 482599811 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459674 NS(=O)(=O)c1ccc(N\C=C\C(=O)c2ccc(Cl)cc2)cc1 InChI=1S/C15H13ClN2O3S/c16-12-3-1-11(2-4-12)15(19)9-10-18-13-5-7-14(8-6-13)22(17,20)21/h1-10,18H,(H2,17,20,21)/b10-9+ ZRBTYTIOTKXEIR-MDZDMXLPSA-N 50588960 CHEMBL5186367 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588960&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168278167 482599812 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459675 NS(=O)(=O)c1ccc(N\C=C\C(=O)c2ccc(Br)cc2)cc1 InChI=1S/C15H13BrN2O3S/c16-12-3-1-11(2-4-12)15(19)9-10-18-13-5-7-14(8-6-13)22(17,20)21/h1-10,18H,(H2,17,20,21)/b10-9+ AJBRGTNOAPZBPH-MDZDMXLPSA-N 50588961 CHEMBL1582269 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588961&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2185394 482599813 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459676 Cc1ccc(cc1)C(=O)\C=C\Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C16H16N2O3S/c1-12-2-4-13(5-3-12)16(19)10-11-18-14-6-8-15(9-7-14)22(17,20)21/h2-11,18H,1H3,(H2,17,20,21)/b11-10+ HLZLDBMTUCMZLC-ZHACJKMWSA-N 50588962 CHEMBL5209465 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588962&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1938971 482599814 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459677 COc1ccc(cc1)C(=O)\C=C\Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C16H16N2O4S/c1-22-14-6-2-12(3-7-14)16(19)10-11-18-13-4-8-15(9-5-13)23(17,20)21/h2-11,18H,1H3,(H2,17,20,21)/b11-10+ AYBJEFYSKMWAOC-ZHACJKMWSA-N 50588963 CHEMBL5190879 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588963&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2248175 482599815 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459678 NS(=O)(=O)c1ccc(N\C=C\C(=O)c2ccc(cc2)[N+]([O-])=O)cc1 InChI=1S/C15H13N3O5S/c16-24(22,23)14-7-3-12(4-8-14)17-10-9-15(19)11-1-5-13(6-2-11)18(20)21/h1-10,17H,(H2,16,22,23)/b10-9+ XOYJWBOEURENBY-MDZDMXLPSA-N 50588964 CHEMBL5187904 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588964&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168283940 482599816 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459679 NS(=O)(=O)c1ccc(N\C=C\C(=O)c2ccc3ccccc3c2)cc1 InChI=1S/C19H16N2O3S/c20-25(23,24)18-9-7-17(8-10-18)21-12-11-19(22)16-6-5-14-3-1-2-4-15(14)13-16/h1-13,21H,(H2,20,23,24)/b12-11+ GZJBVAQVFHTCAD-VAWYXSNFSA-N 50588965 CHEMBL5206090 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588965&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1728123 482599817 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459680 NS(=O)(=O)c1ccc(N\C=C\C(=O)c2ccco2)cc1 InChI=1S/C13H12N2O4S/c14-20(17,18)11-5-3-10(4-6-11)15-8-7-12(16)13-2-1-9-19-13/h1-9,15H,(H2,14,17,18)/b8-7+ GXLWPNZEITZEBS-BQYQJAHWSA-N 50588966 CHEMBL5196961 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588966&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 871981 482599818 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459681 NS(=O)(=O)c1ccc(N\C=C\C(=O)c2cccs2)cc1 InChI=1S/C13H12N2O3S2/c14-20(17,18)11-5-3-10(4-6-11)15-8-7-12(16)13-2-1-9-19-13/h1-9,15H,(H2,14,17,18)/b8-7+ AHBBHQVRKSPPLX-BQYQJAHWSA-N 50588967 CHEMBL5184898 Carbonic anhydrase 4 Homo sapiens 6.5 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588967&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 2258220 482599819 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459770 NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O InChI=1S/C15H10N2O6S/c16-24(22,23)10-4-2-9(3-5-10)17-13(18)11-6-1-8(15(20)21)7-12(11)14(17)19/h1-7H,(H,20,21)(H2,16,22,23) GWFHQFQVQIXUKD-UHFFFAOYSA-N 50589121 CHEMBL5206991 Carbonic anhydrase 4 Homo sapiens 317 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589121&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 869630 482599973 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459771 NS(=O)(=O)c1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O InChI=1S/C15H10N2O6S/c16-24(22,23)10-4-2-9(3-5-10)17-13(18)11-6-1-8(15(20)21)7-12(11)14(17)19/h1-7H,(H,20,21)(H2,16,22,23) GWFHQFQVQIXUKD-UHFFFAOYSA-N 50589121 CHEMBL5206991 Carbonic anhydrase 4 Homo sapiens 317 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589121&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 869630 482599973 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459772 NS(=O)(=O)c1ccc(CN2C(=O)c3ccc(cc3C2=O)C(O)=O)cc1 InChI=1S/C16H12N2O6S/c17-25(23,24)11-4-1-9(2-5-11)8-18-14(19)12-6-3-10(16(21)22)7-13(12)15(18)20/h1-7H,8H2,(H,21,22)(H2,17,23,24) OXXJZVWLYGJXOP-UHFFFAOYSA-N 50589122 CHEMBL5185708 Carbonic anhydrase 4 Homo sapiens 317 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589122&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155806386 482599974 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459773 NS(=O)(=O)c1ccc(CCN2C(=O)c3ccc(cc3C2=O)C(O)=O)cc1 InChI=1S/C17H14N2O6S/c18-26(24,25)12-4-1-10(2-5-12)7-8-19-15(20)13-6-3-11(17(22)23)9-14(13)16(19)21/h1-6,9H,7-8H2,(H,22,23)(H2,18,24,25) GYAMADYYIZTRHJ-UHFFFAOYSA-N 50589123 CHEMBL5193787 Carbonic anhydrase 4 Homo sapiens 317 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589123&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155809525 482599975 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459774 COC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H12N2O6S/c1-24-16(21)9-2-7-12-13(8-9)15(20)18(14(12)19)10-3-5-11(6-4-10)25(17,22)23/h2-8H,1H3,(H2,17,22,23) OWABLTCENMSAGE-UHFFFAOYSA-N 50589124 CHEMBL5186094 Carbonic anhydrase 4 Homo sapiens 317 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589124&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155807963 482599976 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459775 COC(=O)c1ccc2C(=O)N(Cc3ccc(cc3)S(N)(=O)=O)C(=O)c2c1 InChI=1S/C17H14N2O6S/c1-25-17(22)11-4-7-13-14(8-11)16(21)19(15(13)20)9-10-2-5-12(6-3-10)26(18,23)24/h2-8H,9H2,1H3,(H2,18,23,24) NQQBCMKZBQOLKG-UHFFFAOYSA-N 50589125 CHEMBL5204266 Carbonic anhydrase 4 Homo sapiens 317 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589125&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155814243 482599977 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459776 COC(=O)c1ccc2C(=O)N(CCc3ccc(cc3)S(N)(=O)=O)C(=O)c2c1 InChI=1S/C18H16N2O6S/c1-26-18(23)12-4-7-14-15(10-12)17(22)20(16(14)21)9-8-11-2-5-13(6-3-11)27(19,24)25/h2-7,10H,8-9H2,1H3,(H2,19,24,25) NRKNVLOSELMEIT-UHFFFAOYSA-N 50589126 CHEMBL5186839 Carbonic anhydrase 4 Homo sapiens 317 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589126&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155807954 482599978 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459777 OC(=O)c1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O InChI=1S/C16H9NO6/c18-13-11-6-3-9(16(22)23)7-12(11)14(19)17(13)10-4-1-8(2-5-10)15(20)21/h1-7H,(H,20,21)(H,22,23) PRBOQCWKGNKHPS-UHFFFAOYSA-N 50589127 CHEMBL5205452 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589127&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 728460 482599979 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459778 CCOC(=O)c1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O InChI=1S/C18H13NO6/c1-2-25-18(24)10-3-6-12(7-4-10)19-15(20)13-8-5-11(17(22)23)9-14(13)16(19)21/h3-9H,2H2,1H3,(H,22,23) VCAMKOOGZCLSNC-UHFFFAOYSA-N 50589128 CHEMBL5184544 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589128&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 787231 482599980 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459779 COC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccc(cc1)C(O)=O InChI=1S/C17H11NO6/c1-24-17(23)10-4-7-12-13(8-10)15(20)18(14(12)19)11-5-2-9(3-6-11)16(21)22/h2-8H,1H3,(H,21,22) WSCADJRKHBDMEO-UHFFFAOYSA-N 50589129 CHEMBL5202048 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589129&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155814225 482599981 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459780 CCOC(=O)c1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)OC InChI=1S/C19H15NO6/c1-3-26-19(24)11-4-7-13(8-5-11)20-16(21)14-9-6-12(18(23)25-2)10-15(14)17(20)22/h4-10H,3H2,1-2H3 KNGXJTQDUFTJJO-UHFFFAOYSA-N 50589130 CHEMBL5194263 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589130&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155806369 482599982 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459781 OC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccccc1 InChI=1S/C15H9NO4/c17-13-11-7-6-9(15(19)20)8-12(11)14(18)16(13)10-4-2-1-3-5-10/h1-8H,(H,19,20) LJQKDUGNSCMZSJ-UHFFFAOYSA-N 50589131 CHEMBL3746724 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589131&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 20760 482599983 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459782 OC(=O)c1ccc2C(=O)N(Cc3ccccc3)C(=O)c2c1 InChI=1S/C16H11NO4/c18-14-12-7-6-11(16(20)21)8-13(12)15(19)17(14)9-10-4-2-1-3-5-10/h1-8H,9H2,(H,20,21) KGHOAEZOEVGKMU-UHFFFAOYSA-N 50589132 CHEMBL1328975 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589132&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 748193 482599984 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459783 OC(=O)c1ccc2C(=O)N(CCc3ccccc3)C(=O)c2c1 InChI=1S/C17H13NO4/c19-15-13-7-6-12(17(21)22)10-14(13)16(20)18(15)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,21,22) ICDZUDIRGRAYIV-UHFFFAOYSA-N 50589133 CHEMBL1406835 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589133&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 734300 482599985 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459784 COC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccccc1 InChI=1S/C16H11NO4/c1-21-16(20)10-7-8-12-13(9-10)15(19)17(14(12)18)11-5-3-2-4-6-11/h2-9H,1H3 HCCMKPYOWKZBAL-UHFFFAOYSA-N 50589134 CHEMBL5197419 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589134&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 823415 482599986 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459785 COC(=O)c1ccc2C(=O)N(Cc3ccccc3)C(=O)c2c1 InChI=1S/C17H13NO4/c1-22-17(21)12-7-8-13-14(9-12)16(20)18(15(13)19)10-11-5-3-2-4-6-11/h2-9H,10H2,1H3 OFRLJMUYYHONGQ-UHFFFAOYSA-N 50589135 CHEMBL5196434 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589135&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 7738696 482599987 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459786 COC(=O)c1ccc2C(=O)N(CCc3ccccc3)C(=O)c2c1 InChI=1S/C18H15NO4/c1-23-18(22)13-7-8-14-15(11-13)17(21)19(16(14)20)10-9-12-5-3-2-4-6-12/h2-8,11H,9-10H2,1H3 OXSZGBZSXAHQKM-UHFFFAOYSA-N 50589136 CHEMBL5173078 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589136&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 45647236 482599988 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459787 NS(=O)(=O)c1ccc(CN2C(=O)c3ccc(cc3C2=O)C(O)=O)cc1 InChI=1S/C16H12N2O6S/c17-25(23,24)11-4-1-9(2-5-11)8-18-14(19)12-6-3-10(16(21)22)7-13(12)15(18)20/h1-7H,8H2,(H,21,22)(H2,17,23,24) OXXJZVWLYGJXOP-UHFFFAOYSA-N 50589122 CHEMBL5185708 Carbonic anhydrase 4 Homo sapiens 317 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589122&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155806386 482599974 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459788 NS(=O)(=O)c1ccc(CCN2C(=O)c3ccc(cc3C2=O)C(O)=O)cc1 InChI=1S/C17H14N2O6S/c18-26(24,25)12-4-1-10(2-5-12)7-8-19-15(20)13-6-3-11(17(22)23)9-14(13)16(19)21/h1-6,9H,7-8H2,(H,22,23)(H2,18,24,25) GYAMADYYIZTRHJ-UHFFFAOYSA-N 50589123 CHEMBL5193787 Carbonic anhydrase 4 Homo sapiens 317 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589123&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155809525 482599975 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459789 COC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H12N2O6S/c1-24-16(21)9-2-7-12-13(8-9)15(20)18(14(12)19)10-3-5-11(6-4-10)25(17,22)23/h2-8H,1H3,(H2,17,22,23) OWABLTCENMSAGE-UHFFFAOYSA-N 50589124 CHEMBL5186094 Carbonic anhydrase 4 Homo sapiens 317 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589124&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155807963 482599976 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459790 COC(=O)c1ccc2C(=O)N(Cc3ccc(cc3)S(N)(=O)=O)C(=O)c2c1 InChI=1S/C17H14N2O6S/c1-25-17(22)11-4-7-13-14(8-11)16(21)19(15(13)20)9-10-2-5-12(6-3-10)26(18,23)24/h2-8H,9H2,1H3,(H2,18,23,24) NQQBCMKZBQOLKG-UHFFFAOYSA-N 50589125 CHEMBL5204266 Carbonic anhydrase 4 Homo sapiens 317 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589125&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155814243 482599977 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51459791 COC(=O)c1ccc2C(=O)N(CCc3ccc(cc3)S(N)(=O)=O)C(=O)c2c1 InChI=1S/C18H16N2O6S/c1-26-18(23)12-4-7-14-15(10-12)17(22)20(16(14)21)9-8-11-2-5-13(6-3-11)27(19,24)25/h2-7,10H,8-9H2,1H3,(H2,19,24,25) NRKNVLOSELMEIT-UHFFFAOYSA-N 50589126 CHEMBL5186839 Carbonic anhydrase 4 Homo sapiens 317 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50589126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50589126&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155807954 482599978 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458949 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458950 CC(=O)N1N=C(CC1c1ccccc1)c1ccc(OS(N)(=O)=O)cc1 InChI=1S/C17H17N3O4S/c1-12(21)20-17(14-5-3-2-4-6-14)11-16(19-20)13-7-9-15(10-8-13)24-25(18,22)23/h2-10,17H,11H2,1H3,(H2,18,22,23) ZTFVAXOMFNDDQF-UHFFFAOYSA-N 50515814 CHEMBL4540711 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515814&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155549753 440724396 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458951 CC(=O)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(OS(N)(=O)=O)cc1 InChI=1S/C18H16F3N3O4S/c1-11(25)24-17(13-2-6-14(7-3-13)18(19,20)21)10-16(23-24)12-4-8-15(9-5-12)28-29(22,26)27/h2-9,17H,10H2,1H3,(H2,22,26,27) KDPCOXOOFWCXPK-UHFFFAOYSA-N 50515811 CHEMBL4580659 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515811&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155561568 440724393 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458952 CC(=O)N1N=C(CC1c1ccc(cc1)[N+]([O-])=O)c1ccc(OS(N)(=O)=O)cc1 InChI=1S/C17H16N4O6S/c1-11(22)20-17(13-2-6-14(7-3-13)21(23)24)10-16(19-20)12-4-8-15(9-5-12)27-28(18,25)26/h2-9,17H,10H2,1H3,(H2,18,25,26) YOCHWMLSHMATRP-UHFFFAOYSA-N 50515839 CHEMBL4590447 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515839&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155568045 440724421 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458953 CC(=O)N1N=C(CC1c1ccccc1Cl)c1ccc(OS(N)(=O)=O)cc1 InChI=1S/C17H16ClN3O4S/c1-11(22)21-17(14-4-2-3-5-15(14)18)10-16(20-21)12-6-8-13(9-7-12)25-26(19,23)24/h2-9,17H,10H2,1H3,(H2,19,23,24) QJJDIUNMMGRAIA-UHFFFAOYSA-N 50515815 CHEMBL4559197 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515815&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155557875 440724397 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458954 CC(=O)N1N=C(CC1c1cc(Cl)ccc1Cl)c1ccc(OS(N)(=O)=O)cc1 InChI=1S/C17H15Cl2N3O4S/c1-10(23)22-17(14-8-12(18)4-7-15(14)19)9-16(21-22)11-2-5-13(6-3-11)26-27(20,24)25/h2-8,17H,9H2,1H3,(H2,20,24,25) HJHPMKAERBOCJC-UHFFFAOYSA-N 50515838 CHEMBL4459675 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515838&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155527483 440724420 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458955 COc1ccc(cc1)C1=NN(C(C1)c1ccc(OS(N)(=O)=O)cc1)C(C)=O InChI=1S/C18H19N3O5S/c1-12(22)21-18(14-5-9-16(10-6-14)26-27(19,23)24)11-17(20-21)13-3-7-15(25-2)8-4-13/h3-10,18H,11H2,1-2H3,(H2,19,23,24) RHGAKHPDMOCLCI-UHFFFAOYSA-N 50515806 CHEMBL4533252 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515806&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155547275 440724388 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458956 CC(=O)N1N=C(CC1c1cccc(OS(N)(=O)=O)c1)c1ccc(F)cc1 InChI=1S/C17H16FN3O4S/c1-11(22)21-17(10-16(20-21)12-5-7-14(18)8-6-12)13-3-2-4-15(9-13)25-26(19,23)24/h2-9,17H,10H2,1H3,(H2,19,23,24) DAJVBQRSVSECJK-UHFFFAOYSA-N 50515807 CHEMBL4561870 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515807&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155558747 440724389 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458957 Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) RZEKVGVHFLEQIL-UHFFFAOYSA-N 11639 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide::CHEMBL118::CLX::Celebrex::Celecoxib::US10322118, Urea-Based Scaffold Entry 9::US11478464, Compound Celecoxib::US8741944, Comparative Compound::US9388139, Celecoxib::cid_2662 Carbonic anhydrase 4 Homo sapiens 290 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11639&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search CEL 3LN1,3KK6,5JW1,7ZEJ,4FIM,1OQ5 2662 46512162 41423 CHEMBL118 DB00482 2892 C07589 ZINC02570895 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458958 Cc1onc(c1-c1ccc(cc1)S(N)(=O)=O)-c1ccccc1 InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20) LNPDTQAFDNKSHK-UHFFFAOYSA-N 13063 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonamide::Bextra::CHEMBL865::VLX::Valdecoxib::cid_119607 Carbonic anhydrase 4 Homo sapiens 340 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13063&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search COX 2AW1 119607 46513481 63634 CHEMBL865 DB00580 2894 ZINC00006694 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458959 COc1cc(ccc1-c1nc(no1)-c1cccc(F)c1)S(N)(=O)=O InChI=1S/C15H12FN3O4S/c1-22-13-8-11(24(17,20)21)5-6-12(13)15-18-14(19-23-15)9-3-2-4-10(16)7-9/h2-8H,1H3,(H2,17,20,21) QWAPQGDUHGMNIZ-UHFFFAOYSA-N 50588894 CHEMBL5209434 Carbonic anhydrase 4 Homo sapiens 8.9 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588894&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168295044 482599746 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458960 C\C(=N/O)c1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O InChI=1S/C17H12N2O5/c1-9(18-24)10-2-5-12(6-3-10)19-15(20)13-7-4-11(17(22)23)8-14(13)16(19)21/h2-8,24H,1H3,(H,22,23)/b18-9+ SZZXVQKRAXQCBO-GIJQJNRQSA-N 50588875 CHEMBL5199772 Carbonic anhydrase 4 Homo sapiens 3660 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588875&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168291000 482599727 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458961 CC(C)[C@@H](CC(=O)[C@@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)NCCc1ccc(cc1)S(N)(=O)=O InChI=1S/C31H37N3O6S/c1-22(2)27(30(36)33-18-17-23-13-15-26(16-14-23)41(32,38)39)20-29(35)28(19-24-9-5-3-6-10-24)34-31(37)40-21-25-11-7-4-8-12-25/h3-16,22,27-28H,17-21H2,1-2H3,(H,33,36)(H,34,37)(H2,32,38,39)/t27-,28-/m1/s1 XOGCOHICXHZUBW-VSGBNLITSA-N 50588895 CHEMBL5203578 Carbonic anhydrase 4 Homo sapiens 14 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588895&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168293434 482599747 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458962 NS(=O)(=O)c1ccc(cc1)C(=O)NN1C(=O)c2ccc(cc2C1=O)[N+]([O-])=O InChI=1S/C15H10N4O7S/c16-27(25,26)10-4-1-8(2-5-10)13(20)17-18-14(21)11-6-3-9(19(23)24)7-12(11)15(18)22/h1-7H,(H,17,20)(H2,16,25,26) RRAABMTZMWMWSD-UHFFFAOYSA-N 50588896 CHEMBL5203246 Carbonic anhydrase 4 Homo sapiens 3.9 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588896&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168293006 482599748 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458963 C\C(=N/NC(=O)c1ccc(cc1)S(N)(=O)=O)c1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(O)=O InChI=1S/C24H18N4O7S/c1-13(26-27-21(29)15-4-9-18(10-5-15)36(25,34)35)14-2-7-17(8-3-14)28-22(30)19-11-6-16(24(32)33)12-20(19)23(28)31/h2-12H,1H3,(H,27,29)(H,32,33)(H2,25,34,35)/b26-13+ JSALRUWGXXLTSG-LGJNPRDNSA-N 50588882 CHEMBL5195474 Carbonic anhydrase 4 Homo sapiens 406 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588882&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168288899 482599734 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458964 NS(=O)(=O)c1ccc(cc1)C(=O)NN1C(=O)c2cccc(c2C1=O)[N+]([O-])=O InChI=1S/C15H10N4O7S/c16-27(25,26)9-6-4-8(5-7-9)13(20)17-18-14(21)10-2-1-3-11(19(23)24)12(10)15(18)22/h1-7H,(H,17,20)(H2,16,25,26) UNEYTOQJBQJNOQ-UHFFFAOYSA-N 50588897 CHEMBL5207009 Carbonic anhydrase 4 Homo sapiens 3.9 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588897&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168297880 482599749 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51458965 NS(=O)(=O)c1ccc(cc1)C(=O)NN1C(=O)c2ccc(cc2C1=O)C(O)=O InChI=1S/C16H11N3O7S/c17-27(25,26)10-4-1-8(2-5-10)13(20)18-19-14(21)11-6-3-9(16(23)24)7-12(11)15(19)22/h1-7H,(H,18,20)(H,23,24)(H2,17,25,26) CHTDZQLORQKFFG-UHFFFAOYSA-N 50588898 CHEMBL5205140 Carbonic anhydrase 4 Homo sapiens 3.9 ChEMBL 10.7270/Q21N852G 33121862 Kumar, S; Rulhania, S; Jaswal, S; Monga, V ISF College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50588898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50588898&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 168295333 482599750 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51480718 CCN(C1CC(C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O)S(=O)(=O)c1cccc2cccnc12 InChI=1S/C19H21N3O6S4/c1-3-22(32(27,28)16-8-4-6-13-7-5-9-21-18(13)16)15-10-12(2)30(23,24)19-14(15)11-17(29-19)31(20,25)26/h4-9,11-12,15H,3,10H2,1-2H3,(H2,20,25,26) GYXSDLUXZZGBMY-UHFFFAOYSA-N 50596809 CHEMBL5201409 Carbonic anhydrase 4 Homo sapiens 10.0 ChEMBL 10.7270/Q2MC941H 35305463 Swain, B; Sahoo, SK; Singh, P; Angeli, A; Yaddanapudi, VM; Supuran, CT; Arifuddin, M Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596809&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 12050361 482607661 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515011 NS(=O)(=O)c1ccc(cc1)-n1cc(COC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccccc2)nn1 InChI=1S/C24H17N5O6S/c25-36(33,34)19-9-7-17(8-10-19)28-13-16(26-27-28)14-35-24(32)15-6-11-20-21(12-15)23(31)29(22(20)30)18-4-2-1-3-5-18/h1-13H,14H2,(H2,25,33,34) MYAHNUIYYOOZEN-UHFFFAOYSA-N 50609685 CHEMBL5286075 Carbonic anhydrase 4 Homo sapiens 43 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609685&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 171344742 494499433 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515012 NS(=O)(=O)c1ccc(cc1)-n1cc(COC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccccc2Cl)nn1 InChI=1S/C24H16ClN5O6S/c25-20-3-1-2-4-21(20)30-22(31)18-10-5-14(11-19(18)23(30)32)24(33)36-13-15-12-29(28-27-15)16-6-8-17(9-7-16)37(26,34)35/h1-12H,13H2,(H2,26,34,35) MSUMULVHTXISHH-UHFFFAOYSA-N 50609686 CHEMBL5267361 Carbonic anhydrase 4 Homo sapiens 36 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609686&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 171350320 494499434 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515013 NS(=O)(=O)c1ccc(cc1)-n1cc(COC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(Cl)cc2)nn1 InChI=1S/C24H16ClN5O6S/c25-15-2-4-18(5-3-15)30-22(31)20-10-1-14(11-21(20)23(30)32)24(33)36-13-16-12-29(28-27-16)17-6-8-19(9-7-17)37(26,34)35/h1-12H,13H2,(H2,26,34,35) CLELLOLWPKLTHX-UHFFFAOYSA-N 50609687 CHEMBL5288422 Carbonic anhydrase 4 Homo sapiens 30 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609687&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 171351378 494499435 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515014 Cc1cccc(C)c1N1C(=O)c2ccc(cc2C1=O)C(=O)OCc1cn(nn1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C26H21N5O6S/c1-15-4-3-5-16(2)23(15)31-24(32)21-11-6-17(12-22(21)25(31)33)26(34)37-14-18-13-30(29-28-18)19-7-9-20(10-8-19)38(27,35)36/h3-13H,14H2,1-2H3,(H2,27,35,36) OZUYYULYXSVVHQ-UHFFFAOYSA-N 50609688 CHEMBL5271506 Carbonic anhydrase 4 Homo sapiens 33 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609688&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 171342878 494499436 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515015 NS(=O)(=O)c1ccc(cc1)-n1cc(COC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc(F)c2)nn1 InChI=1S/C24H16FN5O6S/c25-15-2-1-3-18(11-15)30-22(31)20-9-4-14(10-21(20)23(30)32)24(33)36-13-16-12-29(28-27-16)17-5-7-19(8-6-17)37(26,34)35/h1-12H,13H2,(H2,26,34,35) ZNBGSCKJUKPSDH-UHFFFAOYSA-N 50609689 CHEMBL5276614 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609689&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 171356249 494499437 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515016 NS(=O)(=O)c1ccc(cc1)-n1cc(COC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccccc2I)nn1 InChI=1S/C24H16IN5O6S/c25-20-3-1-2-4-21(20)30-22(31)18-10-5-14(11-19(18)23(30)32)24(33)36-13-15-12-29(28-27-15)16-6-8-17(9-7-16)37(26,34)35/h1-12H,13H2,(H2,26,34,35) OLVMEDORIQWFPV-UHFFFAOYSA-N 50609690 CHEMBL5284966 Carbonic anhydrase 4 Homo sapiens 26 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609690&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 171347191 494499438 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515017 NS(=O)(=O)c1ccc(cc1)-n1cc(COC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2ccc(cc2)C#N)nn1 InChI=1S/C25H16N6O6S/c26-12-15-1-4-19(5-2-15)31-23(32)21-10-3-16(11-22(21)24(31)33)25(34)37-14-17-13-30(29-28-17)18-6-8-20(9-7-18)38(27,35)36/h1-11,13H,14H2,(H2,27,35,36) WNAIWAZVDQQDMK-UHFFFAOYSA-N 50609691 CHEMBL5287015 Carbonic anhydrase 4 Homo sapiens 35 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609691&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 171347817 494499439 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515018 NS(=O)(=O)c1ccc(cc1)-n1cc(COC(=O)c2ccc3C(=O)N(C(=O)c3c2)c2cccc3ccccc23)nn1 InChI=1S/C28H19N5O6S/c29-40(37,38)21-11-9-20(10-12-21)32-15-19(30-31-32)16-39-28(36)18-8-13-23-24(14-18)27(35)33(26(23)34)25-7-3-5-17-4-1-2-6-22(17)25/h1-15H,16H2,(H2,29,37,38) MWWVNAOGVSRMHH-UHFFFAOYSA-N 50609692 CHEMBL5283764 Carbonic anhydrase 4 Homo sapiens 13 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609692&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 171344935 494499440 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515019 NS(=O)(=O)c1ccc(cc1)-n1cc(COC(=O)c2ccc3C(=O)N(Cc4ccc5OCOc5c4)C(=O)c3c2)nn1 InChI=1S/C26H19N5O8S/c27-40(35,36)19-5-3-18(4-6-19)31-12-17(28-29-31)13-37-26(34)16-2-7-20-21(10-16)25(33)30(24(20)32)11-15-1-8-22-23(9-15)39-14-38-22/h1-10,12H,11,13-14H2,(H2,27,35,36) QNJQVLYQHWMMHP-UHFFFAOYSA-N 50609693 CHEMBL5286828 Carbonic anhydrase 4 Homo sapiens 65 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609693&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 171347810 494499441 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515020 CCCCCCCCN1C(=O)c2ccc(cc2C1=O)C(=O)OCc1cn(nn1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C26H29N5O6S/c1-2-3-4-5-6-7-14-30-24(32)22-13-8-18(15-23(22)25(30)33)26(34)37-17-19-16-31(29-28-19)20-9-11-21(12-10-20)38(27,35)36/h8-13,15-16H,2-7,14,17H2,1H3,(H2,27,35,36) XQOBEXOEPZAQRJ-UHFFFAOYSA-N 50609694 CHEMBL5278587 Carbonic anhydrase 4 Homo sapiens 43 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609694&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 171354066 494499442 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515021 CCCCCCN1C(=O)c2ccc(cc2C1=O)C(=O)OCc1cn(nn1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C24H25N5O6S/c1-2-3-4-5-12-28-22(30)20-11-6-16(13-21(20)23(28)31)24(32)35-15-17-14-29(27-26-17)18-7-9-19(10-8-18)36(25,33)34/h6-11,13-14H,2-5,12,15H2,1H3,(H2,25,33,34) MHKJNNRTQJGJPR-UHFFFAOYSA-N 50609695 CHEMBL5277492 Carbonic anhydrase 4 Homo sapiens 67 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609695&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 171352966 494499443 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515022 CCCCN1C(=O)c2ccc(cc2C1=O)C(=O)OCc1cn(nn1)-c1ccc(cc1)S(N)(=O)=O InChI=1S/C22H21N5O6S/c1-2-3-10-26-20(28)18-9-4-14(11-19(18)21(26)29)22(30)33-13-15-12-27(25-24-15)16-5-7-17(8-6-16)34(23,31)32/h4-9,11-12H,2-3,10,13H2,1H3,(H2,23,31,32) YJFPNKWMXKHGKK-UHFFFAOYSA-N 50609696 CHEMBL5277118 Carbonic anhydrase 4 Homo sapiens 25 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50609696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50609696&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 171355197 494499444 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51515023 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 355 ChEMBL 10.7270/Q2H41WN9 36463726 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,6IM3,8DPO,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51530280 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.7270/Q2T72NQH 32795767 Nehra, B; Rulhania, S; Jaswal, S; Kumar, B; Singh, G; Monga, V Isf College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,6IM3,8DPO,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51530281 CC(=O)N1N=C(CC1c1ccccc1)c1ccc(OS(N)(=O)=O)cc1 InChI=1S/C17H17N3O4S/c1-12(21)20-17(14-5-3-2-4-6-14)11-16(19-20)13-7-9-15(10-8-13)24-25(18,22)23/h2-10,17H,11H2,1H3,(H2,18,22,23) ZTFVAXOMFNDDQF-UHFFFAOYSA-N 50515814 CHEMBL4540711 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q2T72NQH 32795767 Nehra, B; Rulhania, S; Jaswal, S; Kumar, B; Singh, G; Monga, V Isf College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515814&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155549753 440724396 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51530282 CC(=O)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1ccc(OS(N)(=O)=O)cc1 InChI=1S/C18H16F3N3O4S/c1-11(25)24-17(13-2-6-14(7-3-13)18(19,20)21)10-16(23-24)12-4-8-15(9-5-12)28-29(22,26)27/h2-9,17H,10H2,1H3,(H2,22,26,27) KDPCOXOOFWCXPK-UHFFFAOYSA-N 50515811 CHEMBL4580659 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q2T72NQH 32795767 Nehra, B; Rulhania, S; Jaswal, S; Kumar, B; Singh, G; Monga, V Isf College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515811&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155561568 440724393 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51530283 CC(=O)N1N=C(CC1c1ccc(cc1)[N+]([O-])=O)c1ccc(OS(N)(=O)=O)cc1 InChI=1S/C17H16N4O6S/c1-11(22)20-17(13-2-6-14(7-3-13)21(23)24)10-16(19-20)12-4-8-15(9-5-12)27-28(18,25)26/h2-9,17H,10H2,1H3,(H2,18,25,26) YOCHWMLSHMATRP-UHFFFAOYSA-N 50515839 CHEMBL4590447 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q2T72NQH 32795767 Nehra, B; Rulhania, S; Jaswal, S; Kumar, B; Singh, G; Monga, V Isf College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515839&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155568045 440724421 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51530284 CC(=O)N1N=C(CC1c1ccccc1Cl)c1ccc(OS(N)(=O)=O)cc1 InChI=1S/C17H16ClN3O4S/c1-11(22)21-17(14-4-2-3-5-15(14)18)10-16(20-21)12-6-8-13(9-7-12)25-26(19,23)24/h2-9,17H,10H2,1H3,(H2,19,23,24) QJJDIUNMMGRAIA-UHFFFAOYSA-N 50515815 CHEMBL4559197 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q2T72NQH 32795767 Nehra, B; Rulhania, S; Jaswal, S; Kumar, B; Singh, G; Monga, V Isf College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515815&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155557875 440724397 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51530285 CC(=O)N1N=C(CC1c1cc(Cl)ccc1Cl)c1ccc(OS(N)(=O)=O)cc1 InChI=1S/C17H15Cl2N3O4S/c1-10(23)22-17(14-8-12(18)4-7-15(14)19)9-16(21-22)11-2-5-13(6-3-11)26-27(20,24)25/h2-8,17H,9H2,1H3,(H2,20,24,25) HJHPMKAERBOCJC-UHFFFAOYSA-N 50515838 CHEMBL4459675 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q2T72NQH 32795767 Nehra, B; Rulhania, S; Jaswal, S; Kumar, B; Singh, G; Monga, V Isf College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515838&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155527483 440724420 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51530286 COc1ccc(cc1)C1=NN(C(C1)c1ccc(OS(N)(=O)=O)cc1)C(C)=O InChI=1S/C18H19N3O5S/c1-12(22)21-18(14-5-9-16(10-6-14)26-27(19,23)24)11-17(20-21)13-3-7-15(25-2)8-4-13/h3-10,18H,11H2,1-2H3,(H2,19,23,24) RHGAKHPDMOCLCI-UHFFFAOYSA-N 50515806 CHEMBL4533252 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q2T72NQH 32795767 Nehra, B; Rulhania, S; Jaswal, S; Kumar, B; Singh, G; Monga, V Isf College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515806&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155547275 440724388 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51530287 CC(=O)N1N=C(CC1c1cccc(OS(N)(=O)=O)c1)c1ccc(F)cc1 InChI=1S/C17H16FN3O4S/c1-11(22)21-17(10-16(20-21)12-5-7-14(18)8-6-12)13-3-2-4-15(9-13)25-26(19,23)24/h2-9,17H,10H2,1H3,(H2,19,23,24) DAJVBQRSVSECJK-UHFFFAOYSA-N 50515807 CHEMBL4561870 Carbonic anhydrase 4 Homo sapiens 18 ChEMBL 10.7270/Q2T72NQH 32795767 Nehra, B; Rulhania, S; Jaswal, S; Kumar, B; Singh, G; Monga, V Isf College of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515807&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 155558747 440724389 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 1ZNC,3F7B,3F7U,3FW3,5IPZ,5JN8,5JN9,5JNA,5JNC,5KU6 Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552040 NS(=O)(=O)c1ccccc1NC(=O)Nc1nc(-c2ccccc2)n(n1)-c1ccc(F)cc1 InChI=1S/C21H17FN6O3S/c22-15-10-12-16(13-11-15)28-19(14-6-2-1-3-7-14)25-20(27-28)26-21(29)24-17-8-4-5-9-18(17)32(23,30)31/h1-13H,(H2,23,30,31)(H2,24,26,27,29) XRDWYFNRQIGXJP-UHFFFAOYSA-N 50624396 CHEMBL5425764 Carbonic anhydrase 4 Homo sapiens 76 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624396&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552041 NS(=O)(=O)c1ccccc1NC(=O)Nc1nc(-c2ccccc2)n(n1)-c1cccc(Cl)c1 InChI=1S/C21H17ClN6O3S/c22-15-9-6-10-16(13-15)28-19(14-7-2-1-3-8-14)25-20(27-28)26-21(29)24-17-11-4-5-12-18(17)32(23,30)31/h1-13H,(H2,23,30,31)(H2,24,26,27,29) NWNQVFPSDTXSJU-UHFFFAOYSA-N 50624397 CHEMBL5420500 Carbonic anhydrase 4 Homo sapiens 120 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624397&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552042 NS(=O)(=O)c1ccccc1NC(=O)Nc1nc(-c2ccccc2)n(n1)-c1ccc(Cl)cc1 InChI=1S/C21H17ClN6O3S/c22-15-10-12-16(13-11-15)28-19(14-6-2-1-3-7-14)25-20(27-28)26-21(29)24-17-8-4-5-9-18(17)32(23,30)31/h1-13H,(H2,23,30,31)(H2,24,26,27,29) COOFUVUXKTVIPJ-UHFFFAOYSA-N 50624398 CHEMBL5433629 Carbonic anhydrase 4 Homo sapiens 100 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624398&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552043 COc1cccc(c1)-n1nc(NC(=O)Nc2ccccc2S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C22H20N6O4S/c1-32-17-11-7-10-16(14-17)28-20(15-8-3-2-4-9-15)25-21(27-28)26-22(29)24-18-12-5-6-13-19(18)33(23,30)31/h2-14H,1H3,(H2,23,30,31)(H2,24,26,27,29) PWFKWUVNXOXPQY-UHFFFAOYSA-N 50624399 CHEMBL5433631 Carbonic anhydrase 4 Homo sapiens 54 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624399&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552044 COc1ccc(cc1)-n1nc(NC(=O)Nc2ccccc2S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C22H20N6O4S/c1-32-17-13-11-16(12-14-17)28-20(15-7-3-2-4-8-15)25-21(27-28)26-22(29)24-18-9-5-6-10-19(18)33(23,30)31/h2-14H,1H3,(H2,23,30,31)(H2,24,26,27,29) HKKMRTDTKPIQDA-UHFFFAOYSA-N 50624400 CHEMBL5414681 Carbonic anhydrase 4 Homo sapiens 92 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624400&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552045 COc1ccc(cc1OC)-n1nc(NC(=O)Nc2ccccc2S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C23H22N6O5S/c1-33-18-13-12-16(14-19(18)34-2)29-21(15-8-4-3-5-9-15)26-22(28-29)27-23(30)25-17-10-6-7-11-20(17)35(24,31)32/h3-14H,1-2H3,(H2,24,31,32)(H2,25,27,28,30) OFDSMHBYMLGSEU-UHFFFAOYSA-N 50624401 CHEMBL5405122 Carbonic anhydrase 4 Homo sapiens 180 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624401&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552046 NS(=O)(=O)c1cccc(NC(=O)Nc2nc(-c3ccccc3)n(n2)-c2ccc(F)cc2)c1 InChI=1S/C21H17FN6O3S/c22-15-9-11-17(12-10-15)28-19(14-5-2-1-3-6-14)25-20(27-28)26-21(29)24-16-7-4-8-18(13-16)32(23,30)31/h1-13H,(H2,23,30,31)(H2,24,26,27,29) QAYXVHFOFPNFQV-UHFFFAOYSA-N 50624402 CHEMBL5412077 Carbonic anhydrase 4 Homo sapiens 32 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624402&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552047 NS(=O)(=O)c1cccc(NC(=O)Nc2nc(-c3ccccc3)n(n2)-c2cccc(Cl)c2)c1 InChI=1S/C21H17ClN6O3S/c22-15-8-4-10-17(12-15)28-19(14-6-2-1-3-7-14)25-20(27-28)26-21(29)24-16-9-5-11-18(13-16)32(23,30)31/h1-13H,(H2,23,30,31)(H2,24,26,27,29) MYQLYLVPBOSXDN-UHFFFAOYSA-N 50624403 CHEMBL5433578 Carbonic anhydrase 4 Homo sapiens 53 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624403&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552048 NS(=O)(=O)c1cccc(NC(=O)Nc2nc(-c3ccccc3)n(n2)-c2ccc(Cl)cc2)c1 InChI=1S/C21H17ClN6O3S/c22-15-9-11-17(12-10-15)28-19(14-5-2-1-3-6-14)25-20(27-28)26-21(29)24-16-7-4-8-18(13-16)32(23,30)31/h1-13H,(H2,23,30,31)(H2,24,26,27,29) FTUXEEBDSSIQPA-UHFFFAOYSA-N 50624404 CHEMBL5418786 Carbonic anhydrase 4 Homo sapiens 70 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624404&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552049 COc1cccc(c1)-n1nc(NC(=O)Nc2cccc(c2)S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C22H20N6O4S/c1-32-18-11-6-10-17(14-18)28-20(15-7-3-2-4-8-15)25-21(27-28)26-22(29)24-16-9-5-12-19(13-16)33(23,30)31/h2-14H,1H3,(H2,23,30,31)(H2,24,26,27,29) GHICSFRZQKAEBQ-UHFFFAOYSA-N 50624405 CHEMBL5440256 Carbonic anhydrase 4 Homo sapiens 38 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624405&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547917 OB1OCc2ccc(cc12)N=[N+]=[N-] InChI=1S/C7H6BN3O2/c9-11-10-6-2-1-5-4-13-8(12)7(5)3-6/h1-3,12H,4H2 CKFBETOZPBRHSF-UHFFFAOYSA-N 50622622 CHEMBL5431518 Carbonic anhydrase 4 Homo sapiens 3119 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622622&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547918 OB1OCc2ccc(cc12)-n1cc(nn1)-c1ccccc1 InChI=1S/C15H12BN3O2/c20-16-14-8-13(7-6-12(14)10-21-16)19-9-15(17-18-19)11-4-2-1-3-5-11/h1-9,20H,10H2 PBFLVGJFFQOHPJ-UHFFFAOYSA-N 50622623 CHEMBL5421078 Carbonic anhydrase 4 Homo sapiens 1178 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622623&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547919 CCOC(=O)c1cn(nn1)-c1ccc2COB(O)c2c1 InChI=1S/C12H12BN3O4/c1-2-19-12(17)11-6-16(15-14-11)9-4-3-8-7-20-13(18)10(8)5-9/h3-6,18H,2,7H2,1H3 MZWFNJJPXNVDPU-UHFFFAOYSA-N 50622624 CHEMBL5412006 Carbonic anhydrase 4 Homo sapiens 2483 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622624&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547920 OCc1cn(nn1)-c1ccc2COB(O)c2c1 InChI=1S/C10H10BN3O3/c15-5-8-4-14(13-12-8)9-2-1-7-6-17-11(16)10(7)3-9/h1-4,15-16H,5-6H2 STRKIRKKIBQSAK-UHFFFAOYSA-N 50622625 CHEMBL5415766 Carbonic anhydrase 4 Homo sapiens 928 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622625&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547921 OCCc1cn(nn1)-c1ccc2COB(O)c2c1 InChI=1S/C11H12BN3O3/c16-4-3-9-6-15(14-13-9)10-2-1-8-7-18-12(17)11(8)5-10/h1-2,5-6,16-17H,3-4,7H2 YCPYKMUPRIKDKJ-UHFFFAOYSA-N 50622626 CHEMBL5436091 Carbonic anhydrase 4 Homo sapiens 497 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622626&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547922 OB1OCc2ccc(cc12)-n1cc(nn1)C1CC1 InChI=1S/C12H12BN3O2/c17-13-11-5-10(4-3-9(11)7-18-13)16-6-12(14-15-16)8-1-2-8/h3-6,8,17H,1-2,7H2 IDBAGAFMJQAVCF-UHFFFAOYSA-N 50622627 CHEMBL5435151 Carbonic anhydrase 4 Homo sapiens 3217 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622627&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547923 CC(C)(C)OC(=O)NCc1cn(nn1)-c1ccc2COB(O)c2c1 InChI=1S/C15H19BN4O4/c1-15(2,3)24-14(21)17-7-11-8-20(19-18-11)12-5-4-10-9-23-16(22)13(10)6-12/h4-6,8,22H,7,9H2,1-3H3,(H,17,21) HUSLICSGYCKUIR-UHFFFAOYSA-N 50622628 CHEMBL5418946 Carbonic anhydrase 4 Homo sapiens 730 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622628&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547924 OB1OCc2ccc(cc12)-n1cc(nn1)-c1cccc(c1)C(O)=O InChI=1S/C16H12BN3O4/c21-16(22)11-3-1-2-10(6-11)15-8-20(19-18-15)13-5-4-12-9-24-17(23)14(12)7-13/h1-8,23H,9H2,(H,21,22) LIYTWZDPIGJWAT-UHFFFAOYSA-N 50622629 CHEMBL5422467 Carbonic anhydrase 4 Homo sapiens 749 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622629&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547925 OB1OCc2ccc(cc12)-n1cc(COc2ccccc2)nn1 InChI=1S/C16H14BN3O3/c21-17-16-8-14(7-6-12(16)10-23-17)20-9-13(18-19-20)11-22-15-4-2-1-3-5-15/h1-9,21H,10-11H2 KNZBJGVIIFMHFD-UHFFFAOYSA-N 50622630 CHEMBL5440220 Carbonic anhydrase 4 Homo sapiens 1377 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622630&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547926 OB1OCc2ccc(cc12)-n1cc(CSc2ccccc2)nn1 InChI=1S/C16H14BN3O2S/c21-17-16-8-14(7-6-12(16)10-22-17)20-9-13(18-19-20)11-23-15-4-2-1-3-5-15/h1-9,21H,10-11H2 PVFIKRUIKGHNIS-UHFFFAOYSA-N 50622631 CHEMBL5400662 Carbonic anhydrase 4 Homo sapiens 1611 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622631&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547927 OB1OCc2ccc(cc12)-n1cc(COc2ccc(F)cc2)nn1 InChI=1S/C16H13BFN3O3/c18-12-2-5-15(6-3-12)23-10-13-8-21(20-19-13)14-4-1-11-9-24-17(22)16(11)7-14/h1-8,22H,9-10H2 QIWCFKBYVRVGLH-UHFFFAOYSA-N 50622632 CHEMBL5404239 Carbonic anhydrase 4 Homo sapiens 1055 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622632&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547928 COc1ccc(OCc2cn(nn2)-c2ccc3COB(O)c3c2)cc1 InChI=1S/C17H16BN3O4/c1-23-15-4-6-16(7-5-15)24-11-13-9-21(20-19-13)14-3-2-12-10-25-18(22)17(12)8-14/h2-9,22H,10-11H2,1H3 OUKDOMCENIUHQE-UHFFFAOYSA-N 50622633 CHEMBL5402391 Carbonic anhydrase 4 Homo sapiens 1657 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622633&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547929 COc1cccc(OCc2cn(nn2)-c2ccc3COB(O)c3c2)c1 InChI=1S/C17H16BN3O4/c1-23-15-3-2-4-16(8-15)24-11-13-9-21(20-19-13)14-6-5-12-10-25-18(22)17(12)7-14/h2-9,22H,10-11H2,1H3 VPDVUJWSQKEZJT-UHFFFAOYSA-N 50622634 CHEMBL5406460 Carbonic anhydrase 4 Homo sapiens 1928 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622634&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547930 OB1OCc2ccc(cc12)-n1cc(COc2ccc3ccc(=O)oc3c2)nn1 InChI=1S/C19H14BN3O5/c24-19-6-3-12-2-5-16(8-18(12)28-19)26-11-14-9-23(22-21-14)15-4-1-13-10-27-20(25)17(13)7-15/h1-9,25H,10-11H2 WHCLZRQHEBAUHJ-UHFFFAOYSA-N 50622635 CHEMBL5402892 Carbonic anhydrase 4 Homo sapiens 3183 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50622635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50622635&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51547931 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.3c00433 10.7270/Q2X06CFN 37283561 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,6IM3,8DPO,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552050 COc1ccc(cc1)-n1nc(NC(=O)Nc2cccc(c2)S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C22H20N6O4S/c1-32-18-12-10-17(11-13-18)28-20(15-6-3-2-4-7-15)25-21(27-28)26-22(29)24-16-8-5-9-19(14-16)33(23,30)31/h2-14H,1H3,(H2,23,30,31)(H2,24,26,27,29) DHKPFAGTOODDJW-UHFFFAOYSA-N 50624406 CHEMBL5408930 Carbonic anhydrase 4 Homo sapiens 49 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624406&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552051 COc1ccc(cc1OC)-n1nc(NC(=O)Nc2cccc(c2)S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C23H22N6O5S/c1-33-19-12-11-17(14-20(19)34-2)29-21(15-7-4-3-5-8-15)26-22(28-29)27-23(30)25-16-9-6-10-18(13-16)35(24,31)32/h3-14H,1-2H3,(H2,24,31,32)(H2,25,27,28,30) RRBKWQJBCXMXIW-UHFFFAOYSA-N 50624407 CHEMBL5406683 Carbonic anhydrase 4 Homo sapiens 59 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624407&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552052 Cc1ccc(NC(=O)Nc2nc(-c3ccccc3)n(n2)-c2ccc(F)cc2)cc1S(N)(=O)=O InChI=1S/C22H19FN6O3S/c1-14-7-10-17(13-19(14)33(24,31)32)25-22(30)27-21-26-20(15-5-3-2-4-6-15)29(28-21)18-11-8-16(23)9-12-18/h2-13H,1H3,(H2,24,31,32)(H2,25,27,28,30) PPZRTQDMVQKJEM-UHFFFAOYSA-N 50624408 CHEMBL5413914 Carbonic anhydrase 4 Homo sapiens 28 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624408&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552053 Cc1ccc(NC(=O)Nc2nc(-c3ccccc3)n(n2)-c2cccc(Cl)c2)cc1S(N)(=O)=O InChI=1S/C22H19ClN6O3S/c1-14-10-11-17(13-19(14)33(24,31)32)25-22(30)27-21-26-20(15-6-3-2-4-7-15)29(28-21)18-9-5-8-16(23)12-18/h2-13H,1H3,(H2,24,31,32)(H2,25,27,28,30) VCSCKMALZSJPEU-UHFFFAOYSA-N 50624409 CHEMBL5435567 Carbonic anhydrase 4 Homo sapiens 67 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624409&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552054 Cc1ccc(NC(=O)Nc2nc(-c3ccccc3)n(n2)-c2ccc(Cl)cc2)cc1S(N)(=O)=O InChI=1S/C22H19ClN6O3S/c1-14-7-10-17(13-19(14)33(24,31)32)25-22(30)27-21-26-20(15-5-3-2-4-6-15)29(28-21)18-11-8-16(23)9-12-18/h2-13H,1H3,(H2,24,31,32)(H2,25,27,28,30) YUQHZNAHKJBTSY-UHFFFAOYSA-N 50624410 CHEMBL5416544 Carbonic anhydrase 4 Homo sapiens 84 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624410&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552055 COc1cccc(c1)-n1nc(NC(=O)Nc2ccc(C)c(c2)S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C23H22N6O4S/c1-15-11-12-17(13-20(15)34(24,31)32)25-23(30)27-22-26-21(16-7-4-3-5-8-16)29(28-22)18-9-6-10-19(14-18)33-2/h3-14H,1-2H3,(H2,24,31,32)(H2,25,27,28,30) XQWQFSXGSTZKRX-UHFFFAOYSA-N 50624411 CHEMBL5438727 Carbonic anhydrase 4 Homo sapiens 64 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624411&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552056 COc1ccc(cc1)-n1nc(NC(=O)Nc2ccc(C)c(c2)S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C23H22N6O4S/c1-15-8-9-17(14-20(15)34(24,31)32)25-23(30)27-22-26-21(16-6-4-3-5-7-16)29(28-22)18-10-12-19(33-2)13-11-18/h3-14H,1-2H3,(H2,24,31,32)(H2,25,27,28,30) HJFUVWHFUJMBIL-UHFFFAOYSA-N 50624412 CHEMBL5418551 Carbonic anhydrase 4 Homo sapiens 82 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624412&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552057 COc1ccc(cc1OC)-n1nc(NC(=O)Nc2ccc(C)c(c2)S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C24H24N6O5S/c1-15-9-10-17(13-21(15)36(25,32)33)26-24(31)28-23-27-22(16-7-5-4-6-8-16)30(29-23)18-11-12-19(34-2)20(14-18)35-3/h4-14H,1-3H3,(H2,25,32,33)(H2,26,28,29,31) UPDJXCSVBXSCHE-UHFFFAOYSA-N 50624413 CHEMBL5417736 Carbonic anhydrase 4 Homo sapiens 126 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624413&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552058 NS(=O)(=O)c1ccc(NC(=O)Nc2nc(-c3ccccc3)n(n2)-c2ccc(F)cc2)cc1 InChI=1S/C21H17FN6O3S/c22-15-6-10-17(11-7-15)28-19(14-4-2-1-3-5-14)25-20(27-28)26-21(29)24-16-8-12-18(13-9-16)32(23,30)31/h1-13H,(H2,23,30,31)(H2,24,26,27,29) ZXBPLZQLNIALAI-UHFFFAOYSA-N 50624414 CHEMBL5432289 Carbonic anhydrase 4 Homo sapiens 8.3 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624414&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552059 NS(=O)(=O)c1ccc(NC(=O)Nc2nc(-c3ccccc3)n(n2)-c2cccc(Cl)c2)cc1 InChI=1S/C21H17ClN6O3S/c22-15-7-4-8-17(13-15)28-19(14-5-2-1-3-6-14)25-20(27-28)26-21(29)24-16-9-11-18(12-10-16)32(23,30)31/h1-13H,(H2,23,30,31)(H2,24,26,27,29) LAKUGUCGXZVQEE-UHFFFAOYSA-N 50624415 CHEMBL5403355 Carbonic anhydrase 4 Homo sapiens 30 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624415&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552060 NS(=O)(=O)c1ccc(NC(=O)Nc2nc(-c3ccccc3)n(n2)-c2ccc(Cl)cc2)cc1 InChI=1S/C21H17ClN6O3S/c22-15-6-10-17(11-7-15)28-19(14-4-2-1-3-5-14)25-20(27-28)26-21(29)24-16-8-12-18(13-9-16)32(23,30)31/h1-13H,(H2,23,30,31)(H2,24,26,27,29) VZPXSEYTSFPPBI-UHFFFAOYSA-N 50624416 CHEMBL5405733 Carbonic anhydrase 4 Homo sapiens 38 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624416&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552061 COc1cccc(c1)-n1nc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C22H20N6O4S/c1-32-18-9-5-8-17(14-18)28-20(15-6-3-2-4-7-15)25-21(27-28)26-22(29)24-16-10-12-19(13-11-16)33(23,30)31/h2-14H,1H3,(H2,23,30,31)(H2,24,26,27,29) JTCGIYYQCMFLBU-UHFFFAOYSA-N 50624417 CHEMBL5433495 Carbonic anhydrase 4 Homo sapiens 5.2 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624417&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552062 COc1ccc(cc1)-n1nc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C22H20N6O4S/c1-32-18-11-9-17(10-12-18)28-20(15-5-3-2-4-6-15)25-21(27-28)26-22(29)24-16-7-13-19(14-8-16)33(23,30)31/h2-14H,1H3,(H2,23,30,31)(H2,24,26,27,29) ZIXVQKPLYKBLNK-UHFFFAOYSA-N 50624418 CHEMBL5431631 Carbonic anhydrase 4 Homo sapiens 25 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624418&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552063 COc1ccc(cc1OC)-n1nc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C23H22N6O5S/c1-33-19-13-10-17(14-20(19)34-2)29-21(15-6-4-3-5-7-15)26-22(28-29)27-23(30)25-16-8-11-18(12-9-16)35(24,31)32/h3-14H,1-2H3,(H2,24,31,32)(H2,25,27,28,30) HECNGWNECSETNF-UHFFFAOYSA-N 50624419 CHEMBL5411887 Carbonic anhydrase 4 Homo sapiens 19 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624419&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552064 NS(=O)(=O)c1ccc(CCNC(=O)Nc2nc(-c3ccccc3)n(n2)-c2ccc(F)cc2)cc1 InChI=1S/C23H21FN6O3S/c24-18-8-10-19(11-9-18)30-21(17-4-2-1-3-5-17)27-22(29-30)28-23(31)26-15-14-16-6-12-20(13-7-16)34(25,32)33/h1-13H,14-15H2,(H2,25,32,33)(H2,26,28,29,31) QVKUNAKTFMAUJW-UHFFFAOYSA-N 50624420 CHEMBL5435748 Carbonic anhydrase 4 Homo sapiens 2.2 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624420&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552065 NS(=O)(=O)c1ccc(CCNC(=O)Nc2nc(-c3ccccc3)n(n2)-c2cccc(Cl)c2)cc1 InChI=1S/C23H21ClN6O3S/c24-18-7-4-8-19(15-18)30-21(17-5-2-1-3-6-17)27-22(29-30)28-23(31)26-14-13-16-9-11-20(12-10-16)34(25,32)33/h1-12,15H,13-14H2,(H2,25,32,33)(H2,26,28,29,31) WTQFRNPZZFQLLL-UHFFFAOYSA-N 50624421 CHEMBL5422747 Carbonic anhydrase 4 Homo sapiens 5.4 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624421&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552066 NS(=O)(=O)c1ccc(CCNC(=O)Nc2nc(-c3ccccc3)n(n2)-c2ccc(Cl)cc2)cc1 InChI=1S/C23H21ClN6O3S/c24-18-8-10-19(11-9-18)30-21(17-4-2-1-3-5-17)27-22(29-30)28-23(31)26-15-14-16-6-12-20(13-7-16)34(25,32)33/h1-13H,14-15H2,(H2,25,32,33)(H2,26,28,29,31) JUMVFSWBOHODCZ-UHFFFAOYSA-N 50624422 CHEMBL5439333 Carbonic anhydrase 4 Homo sapiens 6.2 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624422&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552067 COc1cccc(c1)-n1nc(NC(=O)NCCc2ccc(cc2)S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C24H24N6O4S/c1-34-20-9-5-8-19(16-20)30-22(18-6-3-2-4-7-18)27-23(29-30)28-24(31)26-15-14-17-10-12-21(13-11-17)35(25,32)33/h2-13,16H,14-15H2,1H3,(H2,25,32,33)(H2,26,28,29,31) ZZJLEHFHCWNROI-UHFFFAOYSA-N 50624423 CHEMBL5438178 Carbonic anhydrase 4 Homo sapiens 9.5 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624423&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552068 COc1ccc(cc1)-n1nc(NC(=O)NCCc2ccc(cc2)S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C24H24N6O4S/c1-34-20-11-9-19(10-12-20)30-22(18-5-3-2-4-6-18)27-23(29-30)28-24(31)26-16-15-17-7-13-21(14-8-17)35(25,32)33/h2-14H,15-16H2,1H3,(H2,25,32,33)(H2,26,28,29,31) ATBYVQKRVYGWAP-UHFFFAOYSA-N 50624424 CHEMBL5399183 Carbonic anhydrase 4 Homo sapiens 17 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624424&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552069 COc1ccc(cc1OC)-n1nc(NC(=O)NCCc2ccc(cc2)S(N)(=O)=O)nc1-c1ccccc1 InChI=1S/C25H26N6O5S/c1-35-21-13-10-19(16-22(21)36-2)31-23(18-6-4-3-5-7-18)28-24(30-31)29-25(32)27-15-14-17-8-11-20(12-9-17)37(26,33)34/h3-13,16H,14-15H2,1-2H3,(H2,26,33,34)(H2,27,29,30,32) KKUXJTUFYBZINZ-UHFFFAOYSA-N 50624425 CHEMBL5437429 Carbonic anhydrase 4 Homo sapiens 23 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624425&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51552070 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 25 ChEMBL 10.1021/acs.jmedchem.3c00721 10.7270/Q2CF9VH0 37501287 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,6IM3,8DPO,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553300 NS(=O)(=O)c1ccc(NC(=O)CSC(=S)N2CCN(CC2)C(c2ccccc2)c2ccccc2)cc1 InChI=1S/C26H28N4O3S3/c27-36(32,33)23-13-11-22(12-14-23)28-24(31)19-35-26(34)30-17-15-29(16-18-30)25(20-7-3-1-4-8-20)21-9-5-2-6-10-21/h1-14,25H,15-19H2,(H,28,31)(H2,27,32,33) VPTBDVGIPAWKIQ-UHFFFAOYSA-N 50624900 CHEMBL5419500 Carbonic anhydrase 4 Homo sapiens 8454 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624900&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553301 NS(=O)(=O)c1ccc(NC(=O)CSC(=S)N2CCN(Cc3ccccc3)CC2)cc1 InChI=1S/C20H24N4O3S3/c21-30(26,27)18-8-6-17(7-9-18)22-19(25)15-29-20(28)24-12-10-23(11-13-24)14-16-4-2-1-3-5-16/h1-9H,10-15H2,(H,22,25)(H2,21,26,27) SWUUKXHSXJMHGU-UHFFFAOYSA-N 50624901 CHEMBL5420864 Carbonic anhydrase 4 Homo sapiens 3400 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624901&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553302 COc1ccccc1N1CCN(CC1)C(=S)SCC(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C20H24N4O4S3/c1-28-18-5-3-2-4-17(18)23-10-12-24(13-11-23)20(29)30-14-19(25)22-15-6-8-16(9-7-15)31(21,26)27/h2-9H,10-14H2,1H3,(H,22,25)(H2,21,26,27) IFIOCBLERUAAFO-UHFFFAOYSA-N 50624902 CHEMBL5438359 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624902&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553303 CCOC(=O)N1CCN(CC1)C(=S)SCC(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C16H22N4O5S3/c1-2-25-15(22)19-7-9-20(10-8-19)16(26)27-11-14(21)18-12-3-5-13(6-4-12)28(17,23)24/h3-6H,2,7-11H2,1H3,(H,18,21)(H2,17,23,24) VZBGQHSBAIOAIQ-UHFFFAOYSA-N 50624903 CHEMBL5408801 Carbonic anhydrase 4 Homo sapiens 779 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624903&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553304 NS(=O)(=O)c1ccc(NC(=O)CSC(=S)N2CCOCC2)cc1 InChI=1S/C13H17N3O4S3/c14-23(18,19)11-3-1-10(2-4-11)15-12(17)9-22-13(21)16-5-7-20-8-6-16/h1-4H,5-9H2,(H,15,17)(H2,14,18,19) VSSITLOFHBZIIL-UHFFFAOYSA-N 50624904 CHEMBL5419817 Carbonic anhydrase 4 Homo sapiens 649 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624904&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553305 NS(=O)(=O)c1ccc(NC(=O)CSC(=S)N2CCCCC2)cc1 InChI=1S/C14H19N3O3S3/c15-23(19,20)12-6-4-11(5-7-12)16-13(18)10-22-14(21)17-8-2-1-3-9-17/h4-7H,1-3,8-10H2,(H,16,18)(H2,15,19,20) BFCSAMMEIRZRTL-UHFFFAOYSA-N 50624905 CHEMBL5432551 Carbonic anhydrase 4 Homo sapiens 406 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624905&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553306 CN1CCN(CC1)C(=S)SCC(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C14H20N4O3S3/c1-17-6-8-18(9-7-17)14(22)23-10-13(19)16-11-2-4-12(5-3-11)24(15,20)21/h2-5H,6-10H2,1H3,(H,16,19)(H2,15,20,21) SMLRBEBCNCWDHG-UHFFFAOYSA-N 50552018 CHEMBL4764100 Carbonic anhydrase 4 Homo sapiens 420 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50552018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50552018&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 162661671 461682358 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553307 CCN1CCN(CC1)C(=S)SCC(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C15H22N4O3S3/c1-2-18-7-9-19(10-8-18)15(23)24-11-14(20)17-12-3-5-13(6-4-12)25(16,21)22/h3-6H,2,7-11H2,1H3,(H,17,20)(H2,16,21,22) KBDQNTITVPILJO-UHFFFAOYSA-N 50624906 CHEMBL5430954 Carbonic anhydrase 4 Homo sapiens 189 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624906&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553308 COc1ccc(cc1)N1CCN(CC1)C(=S)SCC(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C20H24N4O4S3/c1-28-17-6-4-16(5-7-17)23-10-12-24(13-11-23)20(29)30-14-19(25)22-15-2-8-18(9-3-15)31(21,26)27/h2-9H,10-14H2,1H3,(H,22,25)(H2,21,26,27) QSRRCGURRYTUIW-UHFFFAOYSA-N 50624907 CHEMBL5435073 Carbonic anhydrase 4 Homo sapiens 902 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624907&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553309 Cc1ccc(cc1)N1CCN(CC1)C(=S)SCC(=O)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C20H24N4O3S3/c1-15-2-6-17(7-3-15)23-10-12-24(13-11-23)20(28)29-14-19(25)22-16-4-8-18(9-5-16)30(21,26)27/h2-9H,10-14H2,1H3,(H,22,25)(H2,21,26,27) HCIXIBGWGBUVHF-UHFFFAOYSA-N 50624908 CHEMBL5399497 Carbonic anhydrase 4 Homo sapiens 2314 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624908&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553310 NS(=O)(=O)c1ccc(NC(=O)CSC(=S)N2CCN(CC2)c2ccccc2)cc1 InChI=1S/C19H22N4O3S3/c20-29(25,26)17-8-6-15(7-9-17)21-18(24)14-28-19(27)23-12-10-22(11-13-23)16-4-2-1-3-5-16/h1-9H,10-14H2,(H,21,24)(H2,20,25,26) GYAIZZVMWJYEMD-UHFFFAOYSA-N 50624909 CHEMBL5402055 Carbonic anhydrase 4 Homo sapiens 1465 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624909&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553311 NS(=O)(=O)c1ccc(NC(=O)CSC(=S)N2CCN(CC2)c2ccc(F)c(Cl)c2)cc1 InChI=1S/C19H20ClFN4O3S3/c20-16-11-14(3-6-17(16)21)24-7-9-25(10-8-24)19(29)30-12-18(26)23-13-1-4-15(5-2-13)31(22,27)28/h1-6,11H,7-10,12H2,(H,23,26)(H2,22,27,28) NSLQDVBMSOJHFH-UHFFFAOYSA-N 50624910 CHEMBL5432940 Carbonic anhydrase 4 Homo sapiens 2438 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624910&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553312 NS(=O)(=O)c1ccc2nc(NC(=O)CSC(=S)N3CCN(CC3)C(c3ccccc3)c3ccccc3)sc2c1 InChI=1S/C27H27N5O3S4/c28-39(34,35)21-11-12-22-23(17-21)38-26(29-22)30-24(33)18-37-27(36)32-15-13-31(14-16-32)25(19-7-3-1-4-8-19)20-9-5-2-6-10-20/h1-12,17,25H,13-16,18H2,(H2,28,34,35)(H,29,30,33) JOOBCMGRFVLNKS-UHFFFAOYSA-N 50624911 CHEMBL5414672 Carbonic anhydrase 4 Homo sapiens 7644 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624911&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553313 NS(=O)(=O)c1ccc2nc(NC(=O)CSC(=S)N3CCN(Cc4ccccc4)CC3)sc2c1 InChI=1S/C21H23N5O3S4/c22-33(28,29)16-6-7-17-18(12-16)32-20(23-17)24-19(27)14-31-21(30)26-10-8-25(9-11-26)13-15-4-2-1-3-5-15/h1-7,12H,8-11,13-14H2,(H2,22,28,29)(H,23,24,27) ILDXUIQIYSEQCT-UHFFFAOYSA-N 50624912 CHEMBL5413921 Carbonic anhydrase 4 Homo sapiens 5541 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624912&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553314 COc1ccccc1N1CCN(CC1)C(=S)SCC(=O)Nc1nc2ccc(cc2s1)S(N)(=O)=O InChI=1S/C21H23N5O4S4/c1-30-17-5-3-2-4-16(17)25-8-10-26(11-9-25)21(31)32-13-19(27)24-20-23-15-7-6-14(34(22,28)29)12-18(15)33-20/h2-7,12H,8-11,13H2,1H3,(H2,22,28,29)(H,23,24,27) GZCWHTFSDRFJHZ-UHFFFAOYSA-N 50624913 CHEMBL5395842 Carbonic anhydrase 4 Homo sapiens 7256 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624913&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553315 CCOC(=O)N1CCN(CC1)C(=S)SCC(=O)Nc1nc2ccc(cc2s1)S(N)(=O)=O InChI=1S/C17H21N5O5S4/c1-2-27-16(24)21-5-7-22(8-6-21)17(28)29-10-14(23)20-15-19-12-4-3-11(31(18,25)26)9-13(12)30-15/h3-4,9H,2,5-8,10H2,1H3,(H2,18,25,26)(H,19,20,23) OWZOOAOLQAMEPG-UHFFFAOYSA-N 50624914 CHEMBL5427771 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624914&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553316 NS(=O)(=O)c1ccc2nc(NC(=O)CSC(=S)N3CCOCC3)sc2c1 InChI=1S/C14H16N4O4S4/c15-26(20,21)9-1-2-10-11(7-9)25-13(16-10)17-12(19)8-24-14(23)18-3-5-22-6-4-18/h1-2,7H,3-6,8H2,(H2,15,20,21)(H,16,17,19) GZHFJUUKPRLBLE-UHFFFAOYSA-N 50624915 CHEMBL5436862 Carbonic anhydrase 4 Homo sapiens 8122 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624915&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553317 NS(=O)(=O)c1ccc2nc(NC(=O)CSC(=S)N3CCCCC3)sc2c1 InChI=1S/C15H18N4O3S4/c16-26(21,22)10-4-5-11-12(8-10)25-14(17-11)18-13(20)9-24-15(23)19-6-2-1-3-7-19/h4-5,8H,1-3,6-7,9H2,(H2,16,21,22)(H,17,18,20) RLTJTXDLOQHGDZ-UHFFFAOYSA-N 50624916 CHEMBL5420429 Carbonic anhydrase 4 Homo sapiens 7437 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624916&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553318 CN1CCN(CC1)C(=S)SCC(=O)Nc1nc2ccc(cc2s1)S(N)(=O)=O InChI=1S/C15H19N5O3S4/c1-19-4-6-20(7-5-19)15(24)25-9-13(21)18-14-17-11-3-2-10(27(16,22)23)8-12(11)26-14/h2-3,8H,4-7,9H2,1H3,(H2,16,22,23)(H,17,18,21) ONUFUYUXMONZFL-UHFFFAOYSA-N 50624917 CHEMBL5409853 Carbonic anhydrase 4 Homo sapiens 5092 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624917&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553319 CCN1CCN(CC1)C(=S)SCC(=O)Nc1nc2ccc(cc2s1)S(N)(=O)=O InChI=1S/C16H21N5O3S4/c1-2-20-5-7-21(8-6-20)16(25)26-10-14(22)19-15-18-12-4-3-11(28(17,23)24)9-13(12)27-15/h3-4,9H,2,5-8,10H2,1H3,(H2,17,23,24)(H,18,19,22) ODHQVOWCJNWGJT-UHFFFAOYSA-N 50624918 CHEMBL5398870 Carbonic anhydrase 4 Homo sapiens 5932 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624918&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553320 NS(=O)(=O)c1ccc2nc(NC(=O)CSC(=S)N3CCN(CC3)c3ccccc3)sc2c1 InChI=1S/C20H21N5O3S4/c21-32(27,28)15-6-7-16-17(12-15)31-19(22-16)23-18(26)13-30-20(29)25-10-8-24(9-11-25)14-4-2-1-3-5-14/h1-7,12H,8-11,13H2,(H2,21,27,28)(H,22,23,26) HCPNTNXPZHNLDK-UHFFFAOYSA-N 50624919 CHEMBL5423604 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624919&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553321 COc1ccc(cc1)N1CCN(CC1)C(=S)SCC(=O)Nc1nc2ccc(cc2s1)S(N)(=O)=O InChI=1S/C21H23N5O4S4/c1-30-15-4-2-14(3-5-15)25-8-10-26(11-9-25)21(31)32-13-19(27)24-20-23-17-7-6-16(34(22,28)29)12-18(17)33-20/h2-7,12H,8-11,13H2,1H3,(H2,22,28,29)(H,23,24,27) DLIQSOMUXNBLBX-UHFFFAOYSA-N 50624920 CHEMBL5438823 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50624920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50624920&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51553322 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2022.114793 10.7270/Q2QJ7NQK 36201858 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,6IM3,8DPO,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542816 CC(=O)OC[C@H]1O[C@@H]([Se]c2ccc(cc2)S(N)(=O)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O InChI=1S/C20H25NO11SSe/c1-10(22)28-9-16-17(29-11(2)23)18(30-12(3)24)19(31-13(4)25)20(32-16)34-15-7-5-14(6-8-15)33(21,26)27/h5-8,16-20H,9H2,1-4H3,(H2,21,26,27)/t16-,17-,18+,19-,20+/m1/s1 GKNYVICIQGNERP-OBKDMQGPSA-N 50620573 CHEMBL5394374 Carbonic anhydrase 4 Homo sapiens 4118 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620573&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542817 CC(=O)OC[C@H]1O[C@@H]([Se]c2ccc(c(N)c2)S(N)(=O)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O InChI=1S/C20H26N2O11SSe/c1-9(23)29-8-15-17(30-10(2)24)18(31-11(3)25)19(32-12(4)26)20(33-15)35-13-5-6-16(14(21)7-13)34(22,27)28/h5-7,15,17-20H,8,21H2,1-4H3,(H2,22,27,28)/t15-,17-,18+,19-,20+/m1/s1 IMICQPBFCNDVPC-PKOFMYQESA-N 50620574 CHEMBL5422580 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620574&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542818 CC(=O)OC[C@H]1O[C@@H]([Se]c2ccc(cc2)S(N)(=O)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C20H25NO11SSe/c1-10(22)28-9-16-17(29-11(2)23)18(30-12(3)24)19(31-13(4)25)20(32-16)34-15-7-5-14(6-8-15)33(21,26)27/h5-8,16-20H,9H2,1-4H3,(H2,21,26,27)/t16-,17+,18+,19-,20+/m1/s1 GKNYVICIQGNERP-CXQPBAHBSA-N 50620575 CHEMBL5439211 Carbonic anhydrase 4 Homo sapiens 344 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620575&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542819 CC(=O)OC[C@H]1O[C@@H]([Se]c2ccc(c(N)c2)S(N)(=O)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C20H26N2O11SSe/c1-9(23)29-8-15-17(30-10(2)24)18(31-11(3)25)19(32-12(4)26)20(33-15)35-13-5-6-16(14(21)7-13)34(22,27)28/h5-7,15,17-20H,8,21H2,1-4H3,(H2,22,27,28)/t15-,17+,18+,19-,20+/m1/s1 IMICQPBFCNDVPC-ZKIDJSGLSA-N 50620576 CHEMBL5434750 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620576&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542820 NS(=O)(=O)c1ccc([Se][C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 InChI=1S/C12H17NO7SSe/c13-21(18,19)6-1-3-7(4-2-6)22-12-11(17)10(16)9(15)8(5-14)20-12/h1-4,8-12,14-17H,5H2,(H2,13,18,19)/t8-,9-,10+,11-,12+/m1/s1 VNWKPHNIXMNPGQ-ZIQFBCGOSA-N 50620577 CHEMBL5402383 Carbonic anhydrase 4 Homo sapiens 647 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620577&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542821 Nc1cc([Se][C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)ccc1S(N)(=O)=O InChI=1S/C12H18N2O7SSe/c13-6-3-5(1-2-8(6)22(14,19)20)23-12-11(18)10(17)9(16)7(4-15)21-12/h1-3,7,9-12,15-18H,4,13H2,(H2,14,19,20)/t7-,9-,10+,11-,12+/m1/s1 IOUTWIGNKRIKAZ-URYVQPGZSA-N 50620578 CHEMBL5410282 Carbonic anhydrase 4 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620578&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542822 NS(=O)(=O)c1ccc([Se][C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)cc1 InChI=1S/C12H17NO7SSe/c13-21(18,19)6-1-3-7(4-2-6)22-12-11(17)10(16)9(15)8(5-14)20-12/h1-4,8-12,14-17H,5H2,(H2,13,18,19)/t8-,9+,10+,11-,12+/m1/s1 VNWKPHNIXMNPGQ-IIRVCBMXSA-N 50620579 CHEMBL5397739 Carbonic anhydrase 4 Homo sapiens 580 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620579&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542823 CC(=O)O[C@@H]1[C@@H](CO)O[C@@H]([Se]c2ccc(cc2)S(N)(=O)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C18H23NO10SSe/c1-9(21)26-15-14(8-20)29-18(17(28-11(3)23)16(15)27-10(2)22)31-13-6-4-12(5-7-13)30(19,24)25/h4-7,14-18,20H,8H2,1-3H3,(H2,19,24,25)/t14-,15-,16+,17-,18+/m1/s1 CODOYFSQOXGEKI-SFFUCWETSA-N 50620580 CHEMBL5420568 Carbonic anhydrase 4 Homo sapiens 67 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620580&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542824 CC(=O)O[C@H]1[C@@H](CO)O[C@@H]([Se]c2ccc(cc2)S(N)(=O)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C18H23NO10SSe/c1-9(21)26-15-14(8-20)29-18(17(28-11(3)23)16(15)27-10(2)22)31-13-6-4-12(5-7-13)30(19,24)25/h4-7,14-18,20H,8H2,1-3H3,(H2,19,24,25)/t14-,15+,16+,17-,18+/m1/s1 CODOYFSQOXGEKI-ICUGJSFKSA-N 50620581 CHEMBL5406311 Carbonic anhydrase 4 Homo sapiens 146 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620581&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542825 CC(=O)O[C@H]1[C@@H](CO)O[C@@H]([Se]c2ccc(c(N)c2)S(N)(=O)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C18H24N2O10SSe/c1-8(22)27-15-13(7-21)30-18(17(29-10(3)24)16(15)28-9(2)23)32-11-4-5-14(12(19)6-11)31(20,25)26/h4-6,13,15-18,21H,7,19H2,1-3H3,(H2,20,25,26)/t13-,15+,16+,17-,18+/m1/s1 BWFBBSDBGYPACG-XNJHUCFUSA-N 50620582 CHEMBL5425027 Carbonic anhydrase 4 Homo sapiens 7276 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620582&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542826 CC(=O)OC[C@H]1O[C@@H](Sc2ccc(cc2)S(N)(=O)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O InChI=1S/C20H25NO11S2/c1-10(22)28-9-16-17(29-11(2)23)18(30-12(3)24)19(31-13(4)25)20(32-16)33-14-5-7-15(8-6-14)34(21,26)27/h5-8,16-20H,9H2,1-4H3,(H2,21,26,27)/t16-,17-,18+,19-,20+/m1/s1 KWPJXRHMANTYFB-OBKDMQGPSA-N 50620583 CHEMBL5431609 Carbonic anhydrase 4 Homo sapiens 1949 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620583&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542827 CC(=O)OC[C@H]1O[C@@H](Sc2ccc(cc2)S(N)(=O)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C20H25NO11S2/c1-10(22)28-9-16-17(29-11(2)23)18(30-12(3)24)19(31-13(4)25)20(32-16)33-14-5-7-15(8-6-14)34(21,26)27/h5-8,16-20H,9H2,1-4H3,(H2,21,26,27)/t16-,17+,18+,19-,20+/m1/s1 KWPJXRHMANTYFB-CXQPBAHBSA-N 50620584 CHEMBL5434405 Carbonic anhydrase 4 Homo sapiens 1684 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620584&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542828 NS(=O)(=O)c1ccc(S[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 InChI=1S/C12H17NO7S2/c13-22(18,19)7-3-1-6(2-4-7)21-12-11(17)10(16)9(15)8(5-14)20-12/h1-4,8-12,14-17H,5H2,(H2,13,18,19)/t8-,9-,10+,11-,12+/m1/s1 NIQIGNHEHFIPGG-ZIQFBCGOSA-N 50620585 CHEMBL5395672 Carbonic anhydrase 4 Homo sapiens 565 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620585&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search K7P 7ZWB 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542829 NS(=O)(=O)c1ccc(S[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)cc1 InChI=1S/C12H17NO7S2/c13-22(18,19)7-3-1-6(2-4-7)21-12-11(17)10(16)9(15)8(5-14)20-12/h1-4,8-12,14-17H,5H2,(H2,13,18,19)/t8-,9+,10+,11-,12+/m1/s1 NIQIGNHEHFIPGG-IIRVCBMXSA-N 50620586 CHEMBL5416307 Carbonic anhydrase 4 Homo sapiens 467 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620586&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542830 CC(=O)O[C@H]1[C@@H](CO)O[C@@H](Sc2ccc(cc2)S(N)(=O)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C18H23NO10S2/c1-9(21)26-15-14(8-20)29-18(17(28-11(3)23)16(15)27-10(2)22)30-12-4-6-13(7-5-12)31(19,24)25/h4-7,14-18,20H,8H2,1-3H3,(H2,19,24,25)/t14-,15+,16+,17-,18+/m1/s1 GEPXKKLRMYWXND-ICUGJSFKSA-N 50620587 CHEMBL5429492 Carbonic anhydrase 4 Homo sapiens 385 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620587&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542831 CC(=O)OC[C@H]1O[C@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O)S(=O)(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C20H25NO13S2/c1-10(22)30-9-16-17(31-11(2)23)18(32-12(3)24)19(33-13(4)25)20(34-16)35(26,27)14-5-7-15(8-6-14)36(21,28)29/h5-8,16-20H,9H2,1-4H3,(H2,21,28,29)/t16-,17-,18+,19-,20+/m1/s1 JAPWBQCQUOSIEM-OBKDMQGPSA-N 50620588 CHEMBL5433200 Carbonic anhydrase 4 Homo sapiens 587 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620588&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542832 CC(=O)OC[C@H]1O[C@H]([C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O)S(=O)(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C20H25NO13S2/c1-10(22)30-9-16-17(31-11(2)23)18(32-12(3)24)19(33-13(4)25)20(34-16)35(26,27)14-5-7-15(8-6-14)36(21,28)29/h5-8,16-20H,9H2,1-4H3,(H2,21,28,29)/t16-,17+,18+,19-,20+/m1/s1 JAPWBQCQUOSIEM-CXQPBAHBSA-N 50620589 CHEMBL5418092 Carbonic anhydrase 4 Homo sapiens 748 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620589&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542833 NS(=O)(=O)c1ccc(cc1)S(=O)(=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C12H17NO9S2/c13-24(20,21)7-3-1-6(2-4-7)23(18,19)12-11(17)10(16)9(15)8(5-14)22-12/h1-4,8-12,14-17H,5H2,(H2,13,20,21)/t8-,9-,10+,11-,12+/m1/s1 XXGMOMHNKQPBKI-ZIQFBCGOSA-N 50620590 CHEMBL5433722 Carbonic anhydrase 4 Homo sapiens 82 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620590&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542834 CC(=O)OC[C@H]1O[C@@H]([Se]c2ccc(NC(=S)Nc3ccc(cc3)S(N)(=O)=O)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O InChI=1S/C27H31N3O11S2Se/c1-14(31)37-13-22-23(38-15(2)32)24(39-16(3)33)25(40-17(4)34)26(41-22)44-21-11-7-19(8-12-21)30-27(42)29-18-5-9-20(10-6-18)43(28,35)36/h5-12,22-26H,13H2,1-4H3,(H2,28,35,36)(H2,29,30,42)/t22-,23-,24+,25-,26+/m1/s1 VSEAUONETIOWGP-RTJMFUJLSA-N 50620591 CHEMBL5430974 Carbonic anhydrase 4 Homo sapiens 555 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620591&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542835 CC(=O)OC[C@H]1O[C@@H]([Se]c2ccc(NC(=S)Nc3ccc(cc3)S(N)(=O)=O)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C27H31N3O11S2Se/c1-14(31)37-13-22-23(38-15(2)32)24(39-16(3)33)25(40-17(4)34)26(41-22)44-21-11-7-19(8-12-21)30-27(42)29-18-5-9-20(10-6-18)43(28,35)36/h5-12,22-26H,13H2,1-4H3,(H2,28,35,36)(H2,29,30,42)/t22-,23+,24+,25-,26+/m1/s1 VSEAUONETIOWGP-CAKRBILKSA-N 50620592 CHEMBL5420563 Carbonic anhydrase 4 Homo sapiens 362 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620592&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542836 NS(=O)(=O)c1ccc(NC(=S)Nc2ccc([Se][C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)cc2)cc1 InChI=1S/C19H23N3O7S2Se/c20-31(27,28)12-5-1-10(2-6-12)21-19(30)22-11-3-7-13(8-4-11)32-18-17(26)16(25)15(24)14(9-23)29-18/h1-8,14-18,23-26H,9H2,(H2,20,27,28)(H2,21,22,30)/t14-,15+,16+,17-,18+/m1/s1 UZICFNNDQYSEFG-ICUGJSFKSA-N 50620593 CHEMBL5415949 Carbonic anhydrase 4 Homo sapiens 283 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620593&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542837 NS(=O)(=O)c1ccc(NC(=S)Nc2ccc([Se][C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc2)cc1 InChI=1S/C19H23N3O7S2Se/c20-31(27,28)12-5-1-10(2-6-12)21-19(30)22-11-3-7-13(8-4-11)32-18-17(26)16(25)15(24)14(9-23)29-18/h1-8,14-18,23-26H,9H2,(H2,20,27,28)(H2,21,22,30)/t14-,15-,16+,17-,18+/m1/s1 UZICFNNDQYSEFG-SFFUCWETSA-N 50620594 CHEMBL5439370 Carbonic anhydrase 4 Homo sapiens 78 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620594&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542838 CC(=O)OC[C@H]1O[C@@H]([Se]c2ccc(NC(=O)c3ccc(cc3)S(N)(=O)=O)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O InChI=1S/C27H30N2O12SSe/c1-14(30)37-13-22-23(38-15(2)31)24(39-16(3)32)25(40-17(4)33)27(41-22)43-21-11-7-19(8-12-21)29-26(34)18-5-9-20(10-6-18)42(28,35)36/h5-12,22-25,27H,13H2,1-4H3,(H,29,34)(H2,28,35,36)/t22-,23-,24+,25-,27+/m1/s1 JYWGGDIASDQSSD-NUPXYHBHSA-N 50620595 CHEMBL5399412 Carbonic anhydrase 4 Homo sapiens 378 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620595&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542839 CC(=O)OC[C@H]1O[C@@H]([Se]c2ccc(NC(=O)c3ccc(Cl)c(c3)S(N)(=O)=O)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O InChI=1S/C27H29ClN2O12SSe/c1-13(31)38-12-21-23(39-14(2)32)24(40-15(3)33)25(41-16(4)34)27(42-21)44-19-8-6-18(7-9-19)30-26(35)17-5-10-20(28)22(11-17)43(29,36)37/h5-11,21,23-25,27H,12H2,1-4H3,(H,30,35)(H2,29,36,37)/t21-,23-,24+,25-,27+/m1/s1 WPLLGPNHNUOMGV-FOORKGQUSA-N 50620596 CHEMBL5414353 Carbonic anhydrase 4 Homo sapiens 1573 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620596&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542840 CC(=O)OC[C@H]1O[C@@H]([Se]c2ccc(NC(=O)c3ccc(cc3)S(N)(=O)=O)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O InChI=1S/C27H30N2O12SSe/c1-14(30)37-13-22-23(38-15(2)31)24(39-16(3)32)25(40-17(4)33)27(41-22)43-21-11-7-19(8-12-21)29-26(34)18-5-9-20(10-6-18)42(28,35)36/h5-12,22-25,27H,13H2,1-4H3,(H,29,34)(H2,28,35,36)/t22-,23+,24+,25-,27+/m1/s1 JYWGGDIASDQSSD-VJIOPBFVSA-N 50620597 CHEMBL5410769 Carbonic anhydrase 4 Homo sapiens 31 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620597&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542841 NS(=O)(=O)c1ccc(cc1)C(=O)Nc1ccc([Se][C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)cc1 InChI=1S/C19H22N2O8SSe/c20-30(27,28)12-5-1-10(2-6-12)18(26)21-11-3-7-13(8-4-11)31-19-17(25)16(24)15(23)14(9-22)29-19/h1-8,14-17,19,22-25H,9H2,(H,21,26)(H2,20,27,28)/t14-,15+,16+,17-,19+/m1/s1 KWDVVKUGWLQPKD-RDHIYWLCSA-N 50620598 CHEMBL5408414 Carbonic anhydrase 4 Homo sapiens 348 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620598&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542842 NS(=O)(=O)c1cc(ccc1Cl)C(=O)Nc1ccc([Se][C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)cc1 InChI=1S/C19H21ClN2O8SSe/c20-12-6-1-9(7-14(12)31(21,28)29)18(27)22-10-2-4-11(5-3-10)32-19-17(26)16(25)15(24)13(8-23)30-19/h1-7,13,15-17,19,23-26H,8H2,(H,22,27)(H2,21,28,29)/t13-,15+,16+,17-,19+/m1/s1 NIYGRTUCJXAUEL-VGYBTVITSA-N 50620599 CHEMBL5423723 Carbonic anhydrase 4 Homo sapiens 78 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620599&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542843 NS(=O)(=O)c1ccc(cc1)C(=O)Nc1ccc([Se][C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 InChI=1S/C19H22N2O8SSe/c20-30(27,28)12-5-1-10(2-6-12)18(26)21-11-3-7-13(8-4-11)31-19-17(25)16(24)15(23)14(9-22)29-19/h1-8,14-17,19,22-25H,9H2,(H,21,26)(H2,20,27,28)/t14-,15-,16+,17-,19+/m1/s1 KWDVVKUGWLQPKD-ILYVXUQDSA-N 50620600 CHEMBL5418256 Carbonic anhydrase 4 Homo sapiens 8.9 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620600&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542844 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,6IM3,8DPO,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51542845 CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 KJADKKWYZYXHBB-XBWDGYHZSA-N 10887 Sulfamate 7::Topiramate (TPM)::US11535599, Example topiramate::[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate Carbonic anhydrase 4 Homo sapiens 4900 ChEMBL 10.1021/acs.jmedchem.3c00938 10.7270/Q20K2DZR 37436184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10887&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search TOR 3LXE,3HKU,5JNA,7YG5 5284627 46511457 63631 DB00273 6849 C07502 ZINC01530804 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532633 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccc(F)cc1 InChI=1S/C16H18FN5O3S/c17-11-1-3-12(4-2-11)20-16(23)21-13-7-8-22(10-13)15-6-5-14(9-19-15)26(18,24)25/h1-6,9,13H,7-8,10H2,(H2,18,24,25)(H2,20,21,23)/t13-/m1/s1 MAAQNYHAYSKSLH-CYBMUJFWSA-N 50616545 CHEMBL5405279 Carbonic anhydrase 4 Homo sapiens 2656 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616545&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532634 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=O)Nc1ccc(F)cc1 InChI=1S/C16H18FN5O3S/c17-11-1-3-12(4-2-11)20-16(23)21-13-7-8-22(10-13)15-6-5-14(9-19-15)26(18,24)25/h1-6,9,13H,7-8,10H2,(H2,18,24,25)(H2,20,21,23)/t13-/m0/s1 MAAQNYHAYSKSLH-ZDUSSCGKSA-N 50616546 CHEMBL5402145 Carbonic anhydrase 4 Homo sapiens 8242 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616546&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532635 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=S)Nc1ccc(F)cc1 InChI=1S/C16H18FN5O2S2/c17-11-1-3-12(4-2-11)20-16(25)21-13-7-8-22(10-13)15-6-5-14(9-19-15)26(18,23)24/h1-6,9,13H,7-8,10H2,(H2,18,23,24)(H2,20,21,25)/t13-/m1/s1 ZLHNFAACGAYJNG-CYBMUJFWSA-N 50616547 CHEMBL5412351 Carbonic anhydrase 4 Homo sapiens 3115 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616547&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532636 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=S)Nc1ccc(F)cc1 InChI=1S/C16H18FN5O2S2/c17-11-1-3-12(4-2-11)20-16(25)21-13-7-8-22(10-13)15-6-5-14(9-19-15)26(18,23)24/h1-6,9,13H,7-8,10H2,(H2,18,23,24)(H2,20,21,25)/t13-/m0/s1 ZLHNFAACGAYJNG-ZDUSSCGKSA-N 50616548 CHEMBL5413693 Carbonic anhydrase 4 Homo sapiens 2695 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616548&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532637 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=S)Nc1ccccc1 InChI=1S/C16H19N5O2S2/c17-25(22,23)14-6-7-15(18-10-14)21-9-8-13(11-21)20-16(24)19-12-4-2-1-3-5-12/h1-7,10,13H,8-9,11H2,(H2,17,22,23)(H2,19,20,24)/t13-/m1/s1 RURNFMSWOBQBQV-CYBMUJFWSA-N 50616549 CHEMBL5424664 Carbonic anhydrase 4 Homo sapiens 3732 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616549&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532638 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=S)Nc1ccccc1 InChI=1S/C16H19N5O2S2/c17-25(22,23)14-6-7-15(18-10-14)21-9-8-13(11-21)20-16(24)19-12-4-2-1-3-5-12/h1-7,10,13H,8-9,11H2,(H2,17,22,23)(H2,19,20,24)/t13-/m0/s1 RURNFMSWOBQBQV-ZDUSSCGKSA-N 50616550 CHEMBL5429073 Carbonic anhydrase 4 Homo sapiens 9478 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616550&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532639 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F InChI=1S/C17H17ClF3N5O3S/c18-14-3-1-10(7-13(14)17(19,20)21)24-16(27)25-11-5-6-26(9-11)15-4-2-12(8-23-15)30(22,28)29/h1-4,7-8,11H,5-6,9H2,(H2,22,28,29)(H2,24,25,27)/t11-/m1/s1 YDHNVOCAWONJTO-LLVKDONJSA-N 50616551 CHEMBL5404038 Carbonic anhydrase 4 Homo sapiens 4019 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616551&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532640 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F InChI=1S/C17H17ClF3N5O3S/c18-14-3-1-10(7-13(14)17(19,20)21)24-16(27)25-11-5-6-26(9-11)15-4-2-12(8-23-15)30(22,28)29/h1-4,7-8,11H,5-6,9H2,(H2,22,28,29)(H2,24,25,27)/t11-/m0/s1 YDHNVOCAWONJTO-NSHDSACASA-N 50616552 CHEMBL5426216 Carbonic anhydrase 4 Homo sapiens 8516 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616552&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532641 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccccc1F InChI=1S/C16H18FN5O3S/c17-13-3-1-2-4-14(13)21-16(23)20-11-7-8-22(10-11)15-6-5-12(9-19-15)26(18,24)25/h1-6,9,11H,7-8,10H2,(H2,18,24,25)(H2,20,21,23)/t11-/m1/s1 JCECPTHRURCVHN-LLVKDONJSA-N 50616553 CHEMBL5424727 Carbonic anhydrase 4 Homo sapiens 2516 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616553&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532642 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=O)Nc1ccccc1F InChI=1S/C16H18FN5O3S/c17-13-3-1-2-4-14(13)21-16(23)20-11-7-8-22(10-11)15-6-5-12(9-19-15)26(18,24)25/h1-6,9,11H,7-8,10H2,(H2,18,24,25)(H2,20,21,23)/t11-/m0/s1 JCECPTHRURCVHN-NSHDSACASA-N 50616554 CHEMBL5396393 Carbonic anhydrase 4 Homo sapiens 4458 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616554&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532643 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccccc1Cl InChI=1S/C16H18ClN5O3S/c17-13-3-1-2-4-14(13)21-16(23)20-11-7-8-22(10-11)15-6-5-12(9-19-15)26(18,24)25/h1-6,9,11H,7-8,10H2,(H2,18,24,25)(H2,20,21,23)/t11-/m1/s1 OFLLPDPQISYRJB-LLVKDONJSA-N 50616555 CHEMBL5395679 Carbonic anhydrase 4 Homo sapiens 3002 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616555&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532644 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=O)Nc1ccccc1Cl InChI=1S/C16H18ClN5O3S/c17-13-3-1-2-4-14(13)21-16(23)20-11-7-8-22(10-11)15-6-5-12(9-19-15)26(18,24)25/h1-6,9,11H,7-8,10H2,(H2,18,24,25)(H2,20,21,23)/t11-/m0/s1 OFLLPDPQISYRJB-NSHDSACASA-N 50616556 CHEMBL5419447 Carbonic anhydrase 4 Homo sapiens 2031 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616556&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532645 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccc(Oc2ccccc2)cc1 InChI=1S/C22H23N5O4S/c23-32(29,30)20-10-11-21(24-14-20)27-13-12-17(15-27)26-22(28)25-16-6-8-19(9-7-16)31-18-4-2-1-3-5-18/h1-11,14,17H,12-13,15H2,(H2,23,29,30)(H2,25,26,28)/t17-/m1/s1 QXQVZTZWBBZTHB-QGZVFWFLSA-N 50616557 CHEMBL5437142 Carbonic anhydrase 4 Homo sapiens 3079 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616557&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532646 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=O)Nc1ccc(Oc2ccccc2)cc1 InChI=1S/C22H23N5O4S/c23-32(29,30)20-10-11-21(24-14-20)27-13-12-17(15-27)26-22(28)25-16-6-8-19(9-7-16)31-18-4-2-1-3-5-18/h1-11,14,17H,12-13,15H2,(H2,23,29,30)(H2,25,26,28)/t17-/m0/s1 QXQVZTZWBBZTHB-KRWDZBQOSA-N 50616558 CHEMBL5438010 Carbonic anhydrase 4 Homo sapiens 5354 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616558&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532647 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccc(Cl)c(Cl)c1 InChI=1S/C16H17Cl2N5O3S/c17-13-3-1-10(7-14(13)18)21-16(24)22-11-5-6-23(9-11)15-4-2-12(8-20-15)27(19,25)26/h1-4,7-8,11H,5-6,9H2,(H2,19,25,26)(H2,21,22,24)/t11-/m1/s1 OZLZJWIFJUNZOL-LLVKDONJSA-N 50616559 CHEMBL5439318 Carbonic anhydrase 4 Homo sapiens 4903 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616559&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532648 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=O)Nc1ccc(Cl)c(Cl)c1 InChI=1S/C16H17Cl2N5O3S/c17-13-3-1-10(7-14(13)18)21-16(24)22-11-5-6-23(9-11)15-4-2-12(8-20-15)27(19,25)26/h1-4,7-8,11H,5-6,9H2,(H2,19,25,26)(H2,21,22,24)/t11-/m0/s1 OZLZJWIFJUNZOL-NSHDSACASA-N 50616560 CHEMBL5413021 Carbonic anhydrase 4 Homo sapiens 2528 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616560&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532649 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccc2OCCOc2c1 InChI=1S/C18H21N5O5S/c19-29(25,26)14-2-4-17(20-10-14)23-6-5-13(11-23)22-18(24)21-12-1-3-15-16(9-12)28-8-7-27-15/h1-4,9-10,13H,5-8,11H2,(H2,19,25,26)(H2,21,22,24)/t13-/m1/s1 GDZQLCCHUMZPNP-CYBMUJFWSA-N 50616561 CHEMBL5432770 Carbonic anhydrase 4 Homo sapiens 3560 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616561&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532650 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=O)Nc1ccc2OCCOc2c1 InChI=1S/C18H21N5O5S/c19-29(25,26)14-2-4-17(20-10-14)23-6-5-13(11-23)22-18(24)21-12-1-3-15-16(9-12)28-8-7-27-15/h1-4,9-10,13H,5-8,11H2,(H2,19,25,26)(H2,21,22,24)/t13-/m0/s1 GDZQLCCHUMZPNP-ZDUSSCGKSA-N 50616562 CHEMBL5411936 Carbonic anhydrase 4 Homo sapiens 5725 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616562&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532651 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C18H17F6N5O3S/c19-17(20,21)10-5-11(18(22,23)24)7-13(6-10)28-16(30)27-12-3-4-29(9-12)15-2-1-14(8-26-15)33(25,31)32/h1-2,5-8,12H,3-4,9H2,(H2,25,31,32)(H2,27,28,30)/t12-/m1/s1 YSCAFGPFKLJWHV-GFCCVEGCSA-N 50616563 CHEMBL5397659 Carbonic anhydrase 4 Homo sapiens 5161 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616563&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532652 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C18H17F6N5O3S/c19-17(20,21)10-5-11(18(22,23)24)7-13(6-10)28-16(30)27-12-3-4-29(9-12)15-2-1-14(8-26-15)33(25,31)32/h1-2,5-8,12H,3-4,9H2,(H2,25,31,32)(H2,27,28,30)/t12-/m0/s1 YSCAFGPFKLJWHV-LBPRGKRZSA-N 50616564 CHEMBL5414077 Carbonic anhydrase 4 Homo sapiens 2495 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616564&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532653 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=S)Nc1ccc(C2c3ccc(O)cc3Oc3cc(O)ccc23)c(c1)C(O)=O InChI=1S/C30H27N5O7S2/c31-44(40,41)20-4-8-27(32-14-20)35-10-9-17(15-35)34-30(43)33-16-1-5-21(24(11-16)29(38)39)28-22-6-2-18(36)12-25(22)42-26-13-19(37)3-7-23(26)28/h1-8,11-14,17,28,36-37H,9-10,15H2,(H,38,39)(H2,31,40,41)(H2,33,34,43)/t17-/m1/s1 CWLHKJWOLFDCHM-QGZVFWFLSA-N 50616565 CHEMBL5425125 Carbonic anhydrase 4 Homo sapiens 849 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616565&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532654 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=S)Nc1ccc(C2c3ccc(O)cc3Oc3cc(O)ccc23)c(c1)C(O)=O InChI=1S/C30H27N5O7S2/c31-44(40,41)20-4-8-27(32-14-20)35-10-9-17(15-35)34-30(43)33-16-1-5-21(24(11-16)29(38)39)28-22-6-2-18(36)12-25(22)42-26-13-19(37)3-7-23(26)28/h1-8,11-14,17,28,36-37H,9-10,15H2,(H,38,39)(H2,31,40,41)(H2,33,34,43)/t17-/m0/s1 CWLHKJWOLFDCHM-KRWDZBQOSA-N 50616566 CHEMBL5409658 Carbonic anhydrase 4 Homo sapiens 5217 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616566&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532655 COc1ccccc1NC(=O)N[C@@H]1CCN(C1)c1ccc(cn1)S(N)(=O)=O InChI=1S/C17H21N5O4S/c1-26-15-5-3-2-4-14(15)21-17(23)20-12-8-9-22(11-12)16-7-6-13(10-19-16)27(18,24)25/h2-7,10,12H,8-9,11H2,1H3,(H2,18,24,25)(H2,20,21,23)/t12-/m1/s1 LKDHHNQNIRYCTL-GFCCVEGCSA-N 50616567 CHEMBL5402861 Carbonic anhydrase 4 Homo sapiens 5077 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616567&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532656 COc1ccccc1NC(=O)N[C@H]1CCN(C1)c1ccc(cn1)S(N)(=O)=O InChI=1S/C17H21N5O4S/c1-26-15-5-3-2-4-14(15)21-17(23)20-12-8-9-22(11-12)16-7-6-13(10-19-16)27(18,24)25/h2-7,10,12H,8-9,11H2,1H3,(H2,18,24,25)(H2,20,21,23)/t12-/m0/s1 LKDHHNQNIRYCTL-LBPRGKRZSA-N 50616568 CHEMBL5422807 Carbonic anhydrase 4 Homo sapiens 7857 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616568&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532657 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccc(cc1)[N+]([O-])=O InChI=1S/C16H18N6O5S/c17-28(26,27)14-5-6-15(18-9-14)21-8-7-12(10-21)20-16(23)19-11-1-3-13(4-2-11)22(24)25/h1-6,9,12H,7-8,10H2,(H2,17,26,27)(H2,19,20,23)/t12-/m1/s1 HGLYTFYXKZEQKR-GFCCVEGCSA-N 50616569 CHEMBL5420020 Carbonic anhydrase 4 Homo sapiens 1525 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616569&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532658 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=O)Nc1ccc(cc1)[N+]([O-])=O InChI=1S/C16H18N6O5S/c17-28(26,27)14-5-6-15(18-9-14)21-8-7-12(10-21)20-16(23)19-11-1-3-13(4-2-11)22(24)25/h1-6,9,12H,7-8,10H2,(H2,17,26,27)(H2,19,20,23)/t12-/m0/s1 HGLYTFYXKZEQKR-LBPRGKRZSA-N 50616570 CHEMBL5421531 Carbonic anhydrase 4 Homo sapiens 5716 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616570&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532659 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C17H18F3N5O3S/c18-17(19,20)11-1-3-12(4-2-11)23-16(26)24-13-7-8-25(10-13)15-6-5-14(9-22-15)29(21,27)28/h1-6,9,13H,7-8,10H2,(H2,21,27,28)(H2,23,24,26)/t13-/m1/s1 DOPLSTZDQOBCEK-CYBMUJFWSA-N 50616571 CHEMBL5419752 Carbonic anhydrase 4 Homo sapiens 4817 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616571&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532660 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C17H18F3N5O3S/c18-17(19,20)11-1-3-12(4-2-11)23-16(26)24-13-7-8-25(10-13)15-6-5-14(9-22-15)29(21,27)28/h1-6,9,13H,7-8,10H2,(H2,21,27,28)(H2,23,24,26)/t13-/m0/s1 DOPLSTZDQOBCEK-ZDUSSCGKSA-N 50616572 CHEMBL5402143 Carbonic anhydrase 4 Homo sapiens 2686 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616572&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532661 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=S)Nc1ccccc1F InChI=1S/C16H18FN5O2S2/c17-13-3-1-2-4-14(13)21-16(25)20-11-7-8-22(10-11)15-6-5-12(9-19-15)26(18,23)24/h1-6,9,11H,7-8,10H2,(H2,18,23,24)(H2,20,21,25)/t11-/m1/s1 KLQZWEYDBHOBOL-LLVKDONJSA-N 50616573 CHEMBL5420931 Carbonic anhydrase 4 Homo sapiens 3087 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616573&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532662 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=S)Nc1ccccc1F InChI=1S/C16H18FN5O2S2/c17-13-3-1-2-4-14(13)21-16(25)20-11-7-8-22(10-11)15-6-5-12(9-19-15)26(18,23)24/h1-6,9,11H,7-8,10H2,(H2,18,23,24)(H2,20,21,25)/t11-/m0/s1 KLQZWEYDBHOBOL-NSHDSACASA-N 50616574 CHEMBL5401434 Carbonic anhydrase 4 Homo sapiens 843 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616574&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532663 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1c(F)cc(F)cc1Br InChI=1S/C16H16BrF2N5O3S/c17-12-5-9(18)6-13(19)15(12)23-16(25)22-10-3-4-24(8-10)14-2-1-11(7-21-14)28(20,26)27/h1-2,5-7,10H,3-4,8H2,(H2,20,26,27)(H2,22,23,25)/t10-/m1/s1 FIFHTBRNDHDQRL-SNVBAGLBSA-N 50616575 CHEMBL5395857 Carbonic anhydrase 4 Homo sapiens 4883 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616575&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532664 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=O)Nc1c(F)cc(F)cc1Br InChI=1S/C16H16BrF2N5O3S/c17-12-5-9(18)6-13(19)15(12)23-16(25)22-10-3-4-24(8-10)14-2-1-11(7-21-14)28(20,26)27/h1-2,5-7,10H,3-4,8H2,(H2,20,26,27)(H2,22,23,25)/t10-/m0/s1 FIFHTBRNDHDQRL-JTQLQIEISA-N 50616576 CHEMBL5430482 Carbonic anhydrase 4 Homo sapiens 8195 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616576&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532665 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)NS(=O)(=O)c1ccccc1 InChI=1S/C16H19N5O5S2/c17-27(23,24)14-6-7-15(18-10-14)21-9-8-12(11-21)19-16(22)20-28(25,26)13-4-2-1-3-5-13/h1-7,10,12H,8-9,11H2,(H2,17,23,24)(H2,19,20,22)/t12-/m1/s1 LHXRFFVHOQKVOC-GFCCVEGCSA-N 50616577 CHEMBL5398061 Carbonic anhydrase 4 Homo sapiens 37 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616577&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532666 NS(=O)(=O)c1ccc(nc1)N1CC[C@H](C1)NC(=O)NS(=O)(=O)c1ccccc1Cl InChI=1S/C16H18ClN5O5S2/c17-13-3-1-2-4-14(13)29(26,27)21-16(23)20-11-7-8-22(10-11)15-6-5-12(9-19-15)28(18,24)25/h1-6,9,11H,7-8,10H2,(H2,18,24,25)(H2,20,21,23)/t11-/m1/s1 XFOOXOCSAXINFV-LLVKDONJSA-N 50616578 CHEMBL5422153 Carbonic anhydrase 4 Homo sapiens 705 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616578&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532667 NS(=O)(=O)c1ccc(nc1)N1CC[C@@H](C1)NC(=O)NS(=O)(=O)c1ccccc1Cl InChI=1S/C16H18ClN5O5S2/c17-13-3-1-2-4-14(13)29(26,27)21-16(23)20-11-7-8-22(10-11)15-6-5-12(9-19-15)28(18,24)25/h1-6,9,11H,7-8,10H2,(H2,18,24,25)(H2,20,21,23)/t11-/m0/s1 XFOOXOCSAXINFV-NSHDSACASA-N 50616579 CHEMBL5417084 Carbonic anhydrase 4 Homo sapiens 911 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616579&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532668 NS(=O)(=O)c1ccc(NC(=S)N[C@@H]2CCN(C2)c2ccccn2)cc1 InChI=1S/C16H19N5O2S2/c17-25(22,23)14-6-4-12(5-7-14)19-16(24)20-13-8-10-21(11-13)15-3-1-2-9-18-15/h1-7,9,13H,8,10-11H2,(H2,17,22,23)(H2,19,20,24)/t13-/m1/s1 QGZPJORAZASRSN-CYBMUJFWSA-N 50616580 CHEMBL5396530 Carbonic anhydrase 4 Homo sapiens 775 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616580&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532669 NS(=O)(=O)c1cccc(NC(=S)N[C@@H]2CCN(C2)c2ccccn2)c1 InChI=1S/C16H19N5O2S2/c17-25(22,23)14-5-3-4-12(10-14)19-16(24)20-13-7-9-21(11-13)15-6-1-2-8-18-15/h1-6,8,10,13H,7,9,11H2,(H2,17,22,23)(H2,19,20,24)/t13-/m1/s1 UCSMZVJPTHKUHN-CYBMUJFWSA-N 50616581 CHEMBL5409881 Carbonic anhydrase 4 Homo sapiens 320 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616581&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532670 NS(=O)(=O)c1ccc(NC(=S)N[C@@H]2CCN(C2)c2cccc(n2)[N+]([O-])=O)cc1 InChI=1S/C16H18N6O4S2/c17-28(25,26)13-6-4-11(5-7-13)18-16(27)19-12-8-9-21(10-12)14-2-1-3-15(20-14)22(23)24/h1-7,12H,8-10H2,(H2,17,25,26)(H2,18,19,27)/t12-/m1/s1 UGISTPKBCRPMAL-GFCCVEGCSA-N 50616582 CHEMBL5395619 Carbonic anhydrase 4 Homo sapiens 471 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616582&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search QKO 8BOE,8BJX 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532671 NS(=O)(=O)c1ccc(NC(=S)N[C@H]2CCN(C2)c2cccc(n2)[N+]([O-])=O)cc1 InChI=1S/C16H18N6O4S2/c17-28(25,26)13-6-4-11(5-7-13)18-16(27)19-12-8-9-21(10-12)14-2-1-3-15(20-14)22(23)24/h1-7,12H,8-10H2,(H2,17,25,26)(H2,18,19,27)/t12-/m0/s1 UGISTPKBCRPMAL-LBPRGKRZSA-N 50616583 CHEMBL5409460 Carbonic anhydrase 4 Homo sapiens 3203 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616583&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532672 NS(=O)(=O)c1cccc(NC(=S)N[C@@H]2CCN(C2)c2cccc(n2)[N+]([O-])=O)c1 InChI=1S/C16H18N6O4S2/c17-28(25,26)13-4-1-3-11(9-13)18-16(27)19-12-7-8-21(10-12)14-5-2-6-15(20-14)22(23)24/h1-6,9,12H,7-8,10H2,(H2,17,25,26)(H2,18,19,27)/t12-/m1/s1 KCHMTPHYMJFNEW-GFCCVEGCSA-N 50616584 CHEMBL5433154 Carbonic anhydrase 4 Homo sapiens 238 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616584&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532673 NS(=O)(=O)c1cccc(NC(=S)N[C@H]2CCN(C2)c2cccc(n2)[N+]([O-])=O)c1 InChI=1S/C16H18N6O4S2/c17-28(25,26)13-4-1-3-11(9-13)18-16(27)19-12-7-8-21(10-12)14-5-2-6-15(20-14)22(23)24/h1-6,9,12H,7-8,10H2,(H2,17,25,26)(H2,18,19,27)/t12-/m0/s1 KCHMTPHYMJFNEW-LBPRGKRZSA-N 50616585 CHEMBL5421790 Carbonic anhydrase 4 Homo sapiens 1295 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616585&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532674 NS(=O)(=O)c1ccc(NC(=S)N[C@@H]2CCN(C2)c2ccc(cn2)C(F)(F)F)cc1 InChI=1S/C17H18F3N5O2S2/c18-17(19,20)11-1-6-15(22-9-11)25-8-7-13(10-25)24-16(28)23-12-2-4-14(5-3-12)29(21,26)27/h1-6,9,13H,7-8,10H2,(H2,21,26,27)(H2,23,24,28)/t13-/m1/s1 TWNBFLYFNRTBNB-CYBMUJFWSA-N 50616586 CHEMBL5407842 Carbonic anhydrase 4 Homo sapiens 4969 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616586&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532675 NS(=O)(=O)c1ccc(NC(=S)N[C@H]2CCN(C2)c2ccc(cn2)C(F)(F)F)cc1 InChI=1S/C17H18F3N5O2S2/c18-17(19,20)11-1-6-15(22-9-11)25-8-7-13(10-25)24-16(28)23-12-2-4-14(5-3-12)29(21,26)27/h1-6,9,13H,7-8,10H2,(H2,21,26,27)(H2,23,24,28)/t13-/m0/s1 TWNBFLYFNRTBNB-ZDUSSCGKSA-N 50616587 CHEMBL5397521 Carbonic anhydrase 4 Homo sapiens 9722 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616587&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532676 NS(=O)(=O)c1cccc(NC(=S)N[C@@H]2CCN(C2)c2ccc(cn2)C(F)(F)F)c1 InChI=1S/C17H18F3N5O2S2/c18-17(19,20)11-4-5-15(22-9-11)25-7-6-13(10-25)24-16(28)23-12-2-1-3-14(8-12)29(21,26)27/h1-5,8-9,13H,6-7,10H2,(H2,21,26,27)(H2,23,24,28)/t13-/m1/s1 YDUJMIZEUWJICH-CYBMUJFWSA-N 50616588 CHEMBL5399204 Carbonic anhydrase 4 Homo sapiens 806 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616588&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532677 NS(=O)(=O)c1cccc(NC(=S)N[C@H]2CCN(C2)c2ccc(cn2)C(F)(F)F)c1 InChI=1S/C17H18F3N5O2S2/c18-17(19,20)11-4-5-15(22-9-11)25-7-6-13(10-25)24-16(28)23-12-2-1-3-14(8-12)29(21,26)27/h1-5,8-9,13H,6-7,10H2,(H2,21,26,27)(H2,23,24,28)/t13-/m0/s1 YDUJMIZEUWJICH-ZDUSSCGKSA-N 50616589 CHEMBL5403938 Carbonic anhydrase 4 Homo sapiens 669 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616589&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532678 NS(=O)(=O)c1ccc(NC(=O)N[C@@H]2CCN(C2)c2ccccn2)cc1 InChI=1S/C16H19N5O3S/c17-25(23,24)14-6-4-12(5-7-14)19-16(22)20-13-8-10-21(11-13)15-3-1-2-9-18-15/h1-7,9,13H,8,10-11H2,(H2,17,23,24)(H2,19,20,22)/t13-/m1/s1 AVVYBGKZHMLYNV-CYBMUJFWSA-N 50616590 CHEMBL5433765 Carbonic anhydrase 4 Homo sapiens 3511 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616590&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532679 NS(=O)(=O)c1cccc(NC(=O)N[C@@H]2CCN(C2)c2ccccn2)c1 InChI=1S/C16H19N5O3S/c17-25(23,24)14-5-3-4-12(10-14)19-16(22)20-13-7-9-21(11-13)15-6-1-2-8-18-15/h1-6,8,10,13H,7,9,11H2,(H2,17,23,24)(H2,19,20,22)/t13-/m1/s1 GOWQSNLJQVTEQN-CYBMUJFWSA-N 50616591 CHEMBL5436282 Carbonic anhydrase 4 Homo sapiens 2476 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616591&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532680 NS(=O)(=O)c1ccc(NC(=O)N[C@@H]2CCN(C2)c2cccc(n2)[N+]([O-])=O)cc1 InChI=1S/C16H18N6O5S/c17-28(26,27)13-6-4-11(5-7-13)18-16(23)19-12-8-9-21(10-12)14-2-1-3-15(20-14)22(24)25/h1-7,12H,8-10H2,(H2,17,26,27)(H2,18,19,23)/t12-/m1/s1 TZQMARCGMVCRDN-GFCCVEGCSA-N 50616592 CHEMBL5425202 Carbonic anhydrase 4 Homo sapiens 2293 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616592&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532681 NS(=O)(=O)c1ccc(NC(=O)N[C@H]2CCN(C2)c2cccc(n2)[N+]([O-])=O)cc1 InChI=1S/C16H18N6O5S/c17-28(26,27)13-6-4-11(5-7-13)18-16(23)19-12-8-9-21(10-12)14-2-1-3-15(20-14)22(24)25/h1-7,12H,8-10H2,(H2,17,26,27)(H2,18,19,23)/t12-/m0/s1 TZQMARCGMVCRDN-LBPRGKRZSA-N 50616593 CHEMBL5395423 Carbonic anhydrase 4 Homo sapiens 8226 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616593&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532682 NS(=O)(=O)c1cccc(NC(=O)N[C@@H]2CCN(C2)c2cccc(n2)[N+]([O-])=O)c1 InChI=1S/C16H18N6O5S/c17-28(26,27)13-4-1-3-11(9-13)18-16(23)19-12-7-8-21(10-12)14-5-2-6-15(20-14)22(24)25/h1-6,9,12H,7-8,10H2,(H2,17,26,27)(H2,18,19,23)/t12-/m1/s1 FNCNVIQPHOCAGW-GFCCVEGCSA-N 50616594 CHEMBL5440763 Carbonic anhydrase 4 Homo sapiens 2101 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616594&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532683 NS(=O)(=O)c1cccc(NC(=O)N[C@H]2CCN(C2)c2cccc(n2)[N+]([O-])=O)c1 InChI=1S/C16H18N6O5S/c17-28(26,27)13-4-1-3-11(9-13)18-16(23)19-12-7-8-21(10-12)14-5-2-6-15(20-14)22(24)25/h1-6,9,12H,7-8,10H2,(H2,17,26,27)(H2,18,19,23)/t12-/m0/s1 FNCNVIQPHOCAGW-LBPRGKRZSA-N 50616595 CHEMBL5414836 Carbonic anhydrase 4 Homo sapiens 9551 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616595&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532684 NS(=O)(=O)c1ccc(NC(=O)N[C@@H]2CCN(C2)c2ccc(cn2)C(F)(F)F)cc1 InChI=1S/C17H18F3N5O3S/c18-17(19,20)11-1-6-15(22-9-11)25-8-7-13(10-25)24-16(26)23-12-2-4-14(5-3-12)29(21,27)28/h1-6,9,13H,7-8,10H2,(H2,21,27,28)(H2,23,24,26)/t13-/m1/s1 MMXXEFWUHKQSJH-CYBMUJFWSA-N 50616596 CHEMBL5422706 Carbonic anhydrase 4 Homo sapiens 3900 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616596&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532685 NS(=O)(=O)c1ccc(NC(=O)N[C@H]2CCN(C2)c2ccc(cn2)C(F)(F)F)cc1 InChI=1S/C17H18F3N5O3S/c18-17(19,20)11-1-6-15(22-9-11)25-8-7-13(10-25)24-16(26)23-12-2-4-14(5-3-12)29(21,27)28/h1-6,9,13H,7-8,10H2,(H2,21,27,28)(H2,23,24,26)/t13-/m0/s1 MMXXEFWUHKQSJH-ZDUSSCGKSA-N 50616597 CHEMBL5420539 Carbonic anhydrase 4 Homo sapiens 9711 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616597&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532686 NS(=O)(=O)c1cccc(NC(=O)N[C@@H]2CCN(C2)c2ccc(cn2)C(F)(F)F)c1 InChI=1S/C17H18F3N5O3S/c18-17(19,20)11-4-5-15(22-9-11)25-7-6-13(10-25)24-16(26)23-12-2-1-3-14(8-12)29(21,27)28/h1-5,8-9,13H,6-7,10H2,(H2,21,27,28)(H2,23,24,26)/t13-/m1/s1 HNXQPQLHQMZIIO-CYBMUJFWSA-N 50616598 CHEMBL5440906 Carbonic anhydrase 4 Homo sapiens 4023 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616598&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532687 NS(=O)(=O)c1cccc(NC(=O)N[C@H]2CCN(C2)c2ccc(cn2)C(F)(F)F)c1 InChI=1S/C17H18F3N5O3S/c18-17(19,20)11-4-5-15(22-9-11)25-7-6-13(10-25)24-16(26)23-12-2-1-3-14(8-12)29(21,27)28/h1-5,8-9,13H,6-7,10H2,(H2,21,27,28)(H2,23,24,26)/t13-/m0/s1 HNXQPQLHQMZIIO-ZDUSSCGKSA-N 50616599 CHEMBL5411702 Carbonic anhydrase 4 Homo sapiens 8770 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616599&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7 51532688 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 4 Homo sapiens 74 ChEMBL 10.1021/acs.jmedchem.2c01911 10.7270/Q2TB1C81 36626645 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1247&target=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+4&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,6IM3,8DPO,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR 5IPZ,5KU6,5JNC,5JNA,5JN9,5JN8,3FW3,3F7U,3F7B,1ZNC Carbonic anhydrase 4 CAH4_HUMAN P22748 B4DQA4 Q6FHI7