BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 1296643 CC(C)Oc1cc2c(OCC3CNC3)ccnc2cc1C(N)=O InChI=1S/C17H21N3O3/c1-10(2)23-16-6-12-14(5-13(16)17(18)21)20-4-3-15(12)22-9-11-7-19-8-11/h3-6,10-11,19H,7-9H2,1-2H3,(H2,18,21) WDTKSAPTESZOSA-UHFFFAOYSA-N 402347 US10329302, Example 1::US10793579, Example 1::US11702424, Example 1 Interleukin-1 receptor-associated kinase 4 [154-460] 2913 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402347&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118424391 405262337 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296644 CC(C)Oc1cc2c(OC[C@H]3CCCNC3)ccnc2cc1C(N)=O InChI=1S/C19H25N3O3/c1-12(2)25-18-9-14-16(8-15(18)19(20)23)22-7-5-17(14)24-11-13-4-3-6-21-10-13/h5,7-9,12-13,21H,3-4,6,10-11H2,1-2H3,(H2,20,23)/t13-/m0/s1 LGWAIKZDEAAWBY-ZDUSSCGKSA-N 402419 US10329302, Example 2::US10793579, Example 2::US11702424, Example 2 Interleukin-1 receptor-associated kinase 4 [154-460] 4497 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402419&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414516 405262409 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296645 CC(C)Oc1cc2c(OC[C@@H]3CCCNC3)ccnc2cc1C(N)=O InChI=1S/C19H25N3O3/c1-12(2)25-18-9-14-16(8-15(18)19(20)23)22-7-5-17(14)24-11-13-4-3-6-21-10-13/h5,7-9,12-13,21H,3-4,6,10-11H2,1-2H3,(H2,20,23)/t13-/m1/s1 LGWAIKZDEAAWBY-CYBMUJFWSA-N 402631 US10329302, Example 3::US10793579, Example 3::US11702424, Example 3 Interleukin-1 receptor-associated kinase 4 [154-460] 2239 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402631&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414519 405262616 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296646 CC(C)Oc1cc2c(OCC3CCNCC3)ccnc2cc1C(N)=O InChI=1S/C19H25N3O3/c1-12(2)25-18-10-14-16(9-15(18)19(20)23)22-8-5-17(14)24-11-13-3-6-21-7-4-13/h5,8-10,12-13,21H,3-4,6-7,11H2,1-2H3,(H2,20,23) CBXIGDYXIOOJKU-UHFFFAOYSA-N 465898 US10793579, Example 4::US11702424, Example 4 Interleukin-1 receptor-associated kinase 4 [154-460] 913 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=465898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=465898&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118424395 441575606 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296647 CC(C)Oc1cc2c(OC[C@H]3[C@@H]4CNC[C@H]34)ccnc2cc1C(N)=O InChI=1S/C19H23N3O3/c1-10(2)25-18-6-11-16(5-12(18)19(20)23)22-4-3-17(11)24-9-15-13-7-21-8-14(13)15/h3-6,10,13-15,21H,7-9H2,1-2H3,(H2,20,23)/t13-,14+,15+ JBERUJXDAWSSMY-FICVDOATSA-N 402728 US10329302, Example 5::US10793579, Example 5::US11702424, Example 5 Interleukin-1 receptor-associated kinase 4 [154-460] 323 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402728&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414683 405262707 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296648 CC(C)Oc1cc2c(OCC3COC3)ccnc2cc1C(N)=O InChI=1S/C17H20N2O4/c1-10(2)23-16-6-12-14(5-13(16)17(18)20)19-4-3-15(12)22-9-11-7-21-8-11/h3-6,10-11H,7-9H2,1-2H3,(H2,18,20) OURYISMTQDXBJT-UHFFFAOYSA-N 402783 US10329302, Example 6::US10793579, Example 6::US11702424, Example 6 Interleukin-1 receptor-associated kinase 4 [154-460] 618 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402783&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118424392 405262762 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296649 CC(C)Oc1cc2c(OCC3CCCC3)ccnc2cc1C(N)=O InChI=1S/C19H24N2O3/c1-12(2)24-18-10-14-16(9-15(18)19(20)22)21-8-7-17(14)23-11-13-5-3-4-6-13/h7-10,12-13H,3-6,11H2,1-2H3,(H2,20,22) XHDUGHFNQMTLMM-UHFFFAOYSA-N 402827 US10329302, Example 7::US10793579, Example 7::US11702424, Example 7 Interleukin-1 receptor-associated kinase 4 [154-460] 170 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402827&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118424397 405262806 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296650 CC(C)Oc1cc2c(OC(C)C3CCC3)ccnc2cc1C(N)=O InChI=1S/C19H24N2O3/c1-11(2)23-18-10-14-16(9-15(18)19(20)22)21-8-7-17(14)24-12(3)13-5-4-6-13/h7-13H,4-6H2,1-3H3,(H2,20,22) LBSXCKLGGSDDMD-UHFFFAOYSA-N 402858 US10329302, Example 8::US10793579, Example 8::US11702424, Example 8 Interleukin-1 receptor-associated kinase 4 [154-460] 834 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402858&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118424398 405262837 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296651 CC(C)Oc1cc2c(OCC3CCC3)ccnc2cc1C(N)=O InChI=1S/C18H22N2O3/c1-11(2)23-17-9-13-15(8-14(17)18(19)21)20-7-6-16(13)22-10-12-4-3-5-12/h6-9,11-12H,3-5,10H2,1-2H3,(H2,19,21) HWDRPSIAYUAMHW-UHFFFAOYSA-N 402859 US10329302, Example 9::US10793579, Example 9::US11702424, Example 9 Interleukin-1 receptor-associated kinase 4 [154-460] 598 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402859&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118424396 405262838 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296652 CC(C)Oc1cc2c(OCC3CCOC3)ccnc2cc1C(N)=O InChI=1S/C18H22N2O4/c1-11(2)24-17-8-13-15(7-14(17)18(19)21)20-5-3-16(13)23-10-12-4-6-22-9-12/h3,5,7-8,11-12H,4,6,9-10H2,1-2H3,(H2,19,21) FIRJDYAOMYCCGY-UHFFFAOYSA-N 402860 US10329302, Example 10::US10793579, Example 10::US11702424, Example 10 Interleukin-1 receptor-associated kinase 4 [154-460] 752 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402860&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414029 405262839 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296653 CC(C)Oc1cc2c(OCC3CCCO3)ccnc2cc1C(N)=O InChI=1S/C18H22N2O4/c1-11(2)24-17-9-13-15(8-14(17)18(19)21)20-6-5-16(13)23-10-12-4-3-7-22-12/h5-6,8-9,11-12H,3-4,7,10H2,1-2H3,(H2,19,21) NWNWBMADTLGKKS-UHFFFAOYSA-N 402861 US10329302, Example 11::US10793579, Example 11::US11702424, Example 11 Interleukin-1 receptor-associated kinase 4 [154-460] 3234 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402861&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414301 405262840 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296654 CC(C)Oc1cc2c(OCC3(C)COC3)ccnc2cc1C(N)=O InChI=1S/C18H22N2O4/c1-11(2)24-16-7-12-14(6-13(16)17(19)21)20-5-4-15(12)23-10-18(3)8-22-9-18/h4-7,11H,8-10H2,1-3H3,(H2,19,21) LUWGJMBDHBAKTK-UHFFFAOYSA-N 402862 US10329302, Example 12::US10793579, Example 12::US11702424, Example 12 Interleukin-1 receptor-associated kinase 4 [154-460] 1042 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402862&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414338 405262841 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296655 CC(C)Oc1cc2c(OCC3(C)CCC3)ccnc2cc1C(N)=O InChI=1S/C19H24N2O3/c1-12(2)24-17-10-13-15(9-14(17)18(20)22)21-8-5-16(13)23-11-19(3)6-4-7-19/h5,8-10,12H,4,6-7,11H2,1-3H3,(H2,20,22) CGYRHPPSBINKJA-UHFFFAOYSA-N 402863 US10329302, Example 13::US10793579, Example 13::US11702424, Example 13 Interleukin-1 receptor-associated kinase 4 [154-460] 383 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402863&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414640 405262842 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296656 CC(C)Oc1cc2c(O[C@@H]3CC4CCC3C4)ccnc2cc1C(N)=O InChI=1S/C20H24N2O3/c1-11(2)24-19-10-14-16(9-15(19)20(21)23)22-6-5-17(14)25-18-8-12-3-4-13(18)7-12/h5-6,9-13,18H,3-4,7-8H2,1-2H3,(H2,21,23)/t12?,13?,18-/m1/s1 FXZZUOREYIXGKV-PWGQDJSOSA-N 402864 US10329302, Example 14::US10793579, Example 14::US11702424, Example 14 Interleukin-1 receptor-associated kinase 4 [154-460] 231 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402864&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414290 405262843 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296657 CC(C)Oc1cc2c(OC[C@H]3CCCO3)ccnc2cc1C(N)=O InChI=1S/C18H22N2O4/c1-11(2)24-17-9-13-15(8-14(17)18(19)21)20-6-5-16(13)23-10-12-4-3-7-22-12/h5-6,8-9,11-12H,3-4,7,10H2,1-2H3,(H2,19,21)/t12-/m1/s1 NWNWBMADTLGKKS-GFCCVEGCSA-N 402865 US10329302, Example 15::US10793579, Example 15::US11702424, Example 15 Interleukin-1 receptor-associated kinase 4 [154-460] 2969 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402865&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414086 405262844 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296658 CC(C)Oc1cc2c(OC3CC4CCC3C4)ccnc2cc1C(N)=O InChI=1S/C20H24N2O3/c1-11(2)24-19-10-14-16(9-15(19)20(21)23)22-6-5-17(14)25-18-8-12-3-4-13(18)7-12/h5-6,9-13,18H,3-4,7-8H2,1-2H3,(H2,21,23) FXZZUOREYIXGKV-UHFFFAOYSA-N 465910 US10793579, Example 16::US11702424, Example 16 Interleukin-1 receptor-associated kinase 4 [154-460] 386 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=465910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=465910&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414303 441575618 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296659 CC(C)Oc1cc2c(OC3C4C5C[C@H]3CC45)ccnc2cc1C(N)=O InChI=1S/C20H22N2O3/c1-9(2)24-17-8-13-15(7-14(17)20(21)23)22-4-3-16(13)25-19-10-5-11-12(6-10)18(11)19/h3-4,7-12,18-19H,5-6H2,1-2H3,(H2,21,23)/t10-,11?,12?,18?,19? ZCWCQQIEJUQSIL-LWXFGMQSSA-N 402867 US10329302, Example 17::US10793579, Example 17::US11702424, Example 17 Interleukin-1 receptor-associated kinase 4 [154-460] 476 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402867&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414576 405262846 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296660 CC(C)Oc1cc2c(OCC3COCO3)ccnc2cc1C(N)=O InChI=1S/C17H20N2O5/c1-10(2)24-16-6-12-14(5-13(16)17(18)20)19-4-3-15(12)22-8-11-7-21-9-23-11/h3-6,10-11H,7-9H2,1-2H3,(H2,18,20) GSZSBMSWFOHLKA-UHFFFAOYSA-N 402868 US10329302, Example 18::US10793579, Example 18::US11702424, Example 18 Interleukin-1 receptor-associated kinase 4 [154-460] 507 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402868&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414687 405262847 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296661 CC(C)Oc1cc2c(O[C@@H]3CC4CC[C@H]3C4)ccnc2cc1C(N)=O InChI=1S/C20H24N2O3/c1-11(2)24-19-10-14-16(9-15(19)20(21)23)22-6-5-17(14)25-18-8-12-3-4-13(18)7-12/h5-6,9-13,18H,3-4,7-8H2,1-2H3,(H2,21,23)/t12?,13-,18+/m0/s1 FXZZUOREYIXGKV-QLYHWAPBSA-N 402869 US10329302, Example 19::US10793579, Example 19::US11702424, Example 19 Interleukin-1 receptor-associated kinase 4 [154-460] 354 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402869&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414348 405262848 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296662 CC(C)Oc1cc2c(OC3CC[C@@H]4CNC[C@H]34)nccc2cc1C(N)=O InChI=1S/C20H25N3O3/c1-11(2)25-18-8-14-12(7-15(18)19(21)24)5-6-23-20(14)26-17-4-3-13-9-22-10-16(13)17/h5-8,11,13,16-17,22H,3-4,9-10H2,1-2H3,(H2,21,24)/t13-,16+,17?/m1/s1 DVRAVNWCMIWPQD-WBTZKQGOSA-N 402870 US10329302, Example 20::US10793579, Example 20::US11702424, Example 20 Interleukin-1 receptor-associated kinase 4 [154-460] 102 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402870&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414810 405262849 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296663 CC(C)Oc1cc2c(OC3CC[C@@H]4CNC[C@H]34)ccnc2cc1C(N)=O InChI=1S/C20H25N3O3/c1-11(2)25-19-8-13-16(7-14(19)20(21)24)23-6-5-18(13)26-17-4-3-12-9-22-10-15(12)17/h5-8,11-12,15,17,22H,3-4,9-10H2,1-2H3,(H2,21,24)/t12-,15+,17?/m1/s1 IGWIXFJJTZAPGU-AIMZMQLPSA-N 402871 US10329302, Example 21::US10793579, Example 21::US11702424, Example 21 Interleukin-1 receptor-associated kinase 4 [154-460] 83.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402871&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414491 405262850 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296664 CC(C)Oc1cc2c(OC[C@H]3CCN(C3)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C21H24N4O4/c1-13(2)29-19-10-15-17(9-16(19)21(23)27)24-7-4-18(15)28-12-14-5-8-25(11-14)20(26)3-6-22/h4,7,9-10,13-14H,3,5,8,11-12H2,1-2H3,(H2,23,27)/t14-/m0/s1 BWRHZKRIRIHGBU-AWEZNQCLSA-N 402872 US10329302, Example 22::US10793579, Example 22::US11702424, Example 22 Interleukin-1 receptor-associated kinase 4 [154-460] 45.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402872&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414720 405262851 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296666 CC(C)Oc1cc2c(OCC3CCOC3)nccc2cc1C(N)=O InChI=1S/C18H22N2O4/c1-11(2)24-16-8-14-13(7-15(16)17(19)21)3-5-20-18(14)23-10-12-4-6-22-9-12/h3,5,7-8,11-12H,4,6,9-10H2,1-2H3,(H2,19,21) CLFIDOLLOJDRHV-UHFFFAOYSA-N 402874 US10329302, Example 24::US10793579, Example 24::US11702424, Example 24 Interleukin-1 receptor-associated kinase 4 [154-460] 492 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402874&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414825 405262853 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296667 CC(C)Oc1cc2c(OCC3CCCCO3)nccc2cc1C(N)=O InChI=1S/C19H24N2O4/c1-12(2)25-17-10-15-13(9-16(17)18(20)22)6-7-21-19(15)24-11-14-5-3-4-8-23-14/h6-7,9-10,12,14H,3-5,8,11H2,1-2H3,(H2,20,22) ASLWDBZGOCNHHK-UHFFFAOYSA-N 402875 US10329302, Example 25::US10793579, Example 25::US11702424, Example 25 Interleukin-1 receptor-associated kinase 4 [154-460] 1130 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402875&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414792 405262854 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296669 CC(C)Oc1cc2c(OCC3CCCS(=O)(=O)N3)nccc2cc1C(N)=O InChI=1S/C18H23N3O5S/c1-11(2)26-16-9-14-12(8-15(16)17(19)22)5-6-20-18(14)25-10-13-4-3-7-27(23,24)21-13/h5-6,8-9,11,13,21H,3-4,7,10H2,1-2H3,(H2,19,22) IQMOPBLFIMBUEX-UHFFFAOYSA-N 402877 US10329302, Example 27::US10793579, Example 27::US11702424, Example 27 Interleukin-1 receptor-associated kinase 4 [154-460] 2483 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402877&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414865 405262856 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296670 CC(C)Oc1cc2c(OC[C@H]3CCCNC3)nccc2cc1C(N)=O InChI=1S/C19H25N3O3/c1-12(2)25-17-9-15-14(8-16(17)18(20)23)5-7-22-19(15)24-11-13-4-3-6-21-10-13/h5,7-9,12-13,21H,3-4,6,10-11H2,1-2H3,(H2,20,23)/t13-/m0/s1 IHMJXFBIRRLHLD-ZDUSSCGKSA-N 402878 US10329302, Example 28::US11702424, Example 28 Interleukin-1 receptor-associated kinase 4 [154-460] 1320 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402878&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414364 405262857 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296671 CC(C)Oc1cc2c(OCC3COC(=O)N3C)nccc2cc1C(N)=O InChI=1S/C18H21N3O5/c1-10(2)26-15-7-13-11(6-14(15)16(19)22)4-5-20-17(13)24-8-12-9-25-18(23)21(12)3/h4-7,10,12H,8-9H2,1-3H3,(H2,19,22) SHBIFRHNIJTRPU-UHFFFAOYSA-N 402879 US10329302, Example 29::US10793579, Example 29::US11702424, Example 29 Interleukin-1 receptor-associated kinase 4 [154-460] 76.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402879&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414457 405262858 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296672 CC(C)Oc1cc2c(OC[C@H]3CCCO3)nccc2cc1C(N)=O InChI=1S/C18H22N2O4/c1-11(2)24-16-9-14-12(8-15(16)17(19)21)5-6-20-18(14)23-10-13-4-3-7-22-13/h5-6,8-9,11,13H,3-4,7,10H2,1-2H3,(H2,19,21)/t13-/m1/s1 QYELFTUQGKQHGW-CYBMUJFWSA-N 402880 US10329302, Example 30::US10793579, Example 30::US11702424, Example 30 Interleukin-1 receptor-associated kinase 4 [154-460] 2445 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402880&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414578 405262859 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296673 CC(C)Oc1cc2c(OC[C@@H]3CCCN3C)nccc2cc1C(N)=O InChI=1S/C19H25N3O3/c1-12(2)25-17-10-15-13(9-16(17)18(20)23)6-7-21-19(15)24-11-14-5-4-8-22(14)3/h6-7,9-10,12,14H,4-5,8,11H2,1-3H3,(H2,20,23)/t14-/m0/s1 YMCHUNAHASKTRR-AWEZNQCLSA-N 402881 US10329302, Example 31::US10793579, Example 31::US11702424, Example 31 Interleukin-1 receptor-associated kinase 4 [154-460] 2616 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402881&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414645 405262860 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296675 CC(C)Oc1cc2c(OCC3CCN(CC3)C(C)=O)nccc2cc1C(N)=O InChI=1S/C21H27N3O4/c1-13(2)28-19-11-17-16(10-18(19)20(22)26)4-7-23-21(17)27-12-15-5-8-24(9-6-15)14(3)25/h4,7,10-11,13,15H,5-6,8-9,12H2,1-3H3,(H2,22,26) JSINXFGHZGHSON-UHFFFAOYSA-N 402883 US10329302, Example 33::US10793579, Example 33::US11702424, Example 33 Interleukin-1 receptor-associated kinase 4 [154-460] 2862 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402883&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414695 405262862 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296676 CO[C@H]1CNC[C@@H]1COc1nccc2cc(C(N)=O)c(OC(C)C)cc12 InChI=1S/C19H25N3O4/c1-11(2)26-16-7-14-12(6-15(16)18(20)23)4-5-22-19(14)25-10-13-8-21-9-17(13)24-3/h4-7,11,13,17,21H,8-10H2,1-3H3,(H2,20,23)/t13-,17+/m1/s1 XRERNVAETQOOQT-DYVFJYSZSA-N 402884 US10329302, Example 34::US10793579, Example 34::US11702424, Example 34 Interleukin-1 receptor-associated kinase 4 [154-460] 483 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402884&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414532 405262863 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296677 CC(C)Oc1cc2c(OCC3CNC(=O)O3)nccc2cc1C(N)=O InChI=1S/C17H19N3O5/c1-9(2)24-14-6-12-10(5-13(14)15(18)21)3-4-19-16(12)23-8-11-7-20-17(22)25-11/h3-6,9,11H,7-8H2,1-2H3,(H2,18,21)(H,20,22) KYOOBHWYOVVDAO-UHFFFAOYSA-N 402885 US10329302, Example 35::US10793579, Example 35::US11702424, Example 35 Interleukin-1 receptor-associated kinase 4 [154-460] 16.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402885&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414765 405262864 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296678 CC(C)Oc1cc2c(OCC3CCOCC3)nccc2cc1C(N)=O InChI=1S/C19H24N2O4/c1-12(2)25-17-10-15-14(9-16(17)18(20)22)3-6-21-19(15)24-11-13-4-7-23-8-5-13/h3,6,9-10,12-13H,4-5,7-8,11H2,1-2H3,(H2,20,22) FBIJWOSYRAIINT-UHFFFAOYSA-N 402886 US10329302, Example 36::US10793579, Example 36::US11702424, Example 36 Interleukin-1 receptor-associated kinase 4 [154-460] 735 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402886&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414622 405262865 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296679 CC(C)Oc1cc2c(OC[C@@H]3CNCCO3)nccc2cc1C(N)=O InChI=1S/C18H23N3O4/c1-11(2)25-16-8-14-12(7-15(16)17(19)22)3-4-21-18(14)24-10-13-9-20-5-6-23-13/h3-4,7-8,11,13,20H,5-6,9-10H2,1-2H3,(H2,19,22)/t13-/m0/s1 SYMLNGYLCIGOCJ-ZDUSSCGKSA-N 402887 US10329302, Example 37::US10793579, Example 37::US11702424, Example 37 Interleukin-1 receptor-associated kinase 4 [154-460] 3516 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402887&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414283 405262866 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296680 CC(C)Oc1cc2c(OCC3(F)CCNCC3)nccc2cc1C(N)=O InChI=1S/C19H24FN3O3/c1-12(2)26-16-10-14-13(9-15(16)17(21)24)3-6-23-18(14)25-11-19(20)4-7-22-8-5-19/h3,6,9-10,12,22H,4-5,7-8,11H2,1-2H3,(H2,21,24) HTZZCVHWGLAOEM-UHFFFAOYSA-N 402888 US10329302, Example 38::US10793579, Example 38::US11702424, Example 38 Interleukin-1 receptor-associated kinase 4 [154-460] 4640 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402888&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414584 405262867 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296681 CC(C)Oc1cc2c(OCC3CNCCO3)nccc2cc1C(N)=O InChI=1S/C18H23N3O4/c1-11(2)25-16-8-14-12(7-15(16)17(19)22)3-4-21-18(14)24-10-13-9-20-5-6-23-13/h3-4,7-8,11,13,20H,5-6,9-10H2,1-2H3,(H2,19,22) SYMLNGYLCIGOCJ-UHFFFAOYSA-N 402889 US10329302, Example 39::US10793579, Example 39::US11702424, Example 39 Interleukin-1 receptor-associated kinase 4 [154-460] 386 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402889&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414285 405262868 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296682 CC(C)Oc1cc2c(OC[C@@]34C[C@@H]3CNC4)nccc2cc1C(N)=O InChI=1S/C19H23N3O3/c1-11(2)25-16-6-14-12(5-15(16)17(20)23)3-4-22-18(14)24-10-19-7-13(19)8-21-9-19/h3-6,11,13,21H,7-10H2,1-2H3,(H2,20,23)/t13-,19+/m1/s1 LPMZEDIWGJMIEH-YJYMSZOUSA-N 402890 US10329302, Example 139::US10329302, Example 40::US10793579, Example 139::US11702424, Example 139 Interleukin-1 receptor-associated kinase 4 [154-460] 109 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402890&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414782 405262869 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296683 CC(C)Oc1cc2c(OC[C@H]3CCCN3)nccc2cc1C(N)=O InChI=1S/C18H23N3O3/c1-11(2)24-16-9-14-12(8-15(16)17(19)22)5-7-21-18(14)23-10-13-4-3-6-20-13/h5,7-9,11,13,20H,3-4,6,10H2,1-2H3,(H2,19,22)/t13-/m1/s1 IBVBHRGRNBEHPT-CYBMUJFWSA-N 402891 US10329302, Example 41::US10793579, Example 41::US11702424, Example 41 Interleukin-1 receptor-associated kinase 4 [154-460] 2351 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402891&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414843 405262870 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296684 CC(C)Oc1cc2c(OC[C@H]3[C@@H]4CNC[C@H]34)nccc2cc1C(N)=O InChI=1S/C19H23N3O3/c1-10(2)25-17-6-12-11(5-13(17)18(20)23)3-4-22-19(12)24-9-16-14-7-21-8-15(14)16/h3-6,10,14-16,21H,7-9H2,1-2H3,(H2,20,23)/t14-,15+,16+ ZCGCXROFKLMMNN-ZSHCYNCHSA-N 402894 US10329302, Example 42::US10793579, Example 42::US11702424, Example 42 Interleukin-1 receptor-associated kinase 4 [154-460] 219 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402894&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414345 405262873 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296685 CC(C)Oc1cc2c(OCC3CCCCN3)nccc2cc1C(N)=O InChI=1S/C19H25N3O3/c1-12(2)25-17-10-15-13(9-16(17)18(20)23)6-8-22-19(15)24-11-14-5-3-4-7-21-14/h6,8-10,12,14,21H,3-5,7,11H2,1-2H3,(H2,20,23) GHTLIJZTITZADA-UHFFFAOYSA-N 402895 US10329302, Example 43::US10793579, Example 43::US11702424, Example 43 Interleukin-1 receptor-associated kinase 4 [154-460] 3323 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402895&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414374 405262874 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296686 CC(C)Oc1cc2c(OCC3CN(C)CCO3)nccc2cc1C(N)=O InChI=1S/C19H25N3O4/c1-12(2)26-17-9-15-13(8-16(17)18(20)23)4-5-21-19(15)25-11-14-10-22(3)6-7-24-14/h4-5,8-9,12,14H,6-7,10-11H2,1-3H3,(H2,20,23) VGBLZPUJWXCOAE-UHFFFAOYSA-N 402896 US10329302, Example 44::US10793579, Example 44::US11702424, Example 44 Interleukin-1 receptor-associated kinase 4 [154-460] 4265 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402896&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414335 405262875 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296687 CC(C)Oc1cc2c(OCC3CCCN(C)C3)nccc2cc1C(N)=O InChI=1S/C20H27N3O3/c1-13(2)26-18-10-16-15(9-17(18)19(21)24)6-7-22-20(16)25-12-14-5-4-8-23(3)11-14/h6-7,9-10,13-14H,4-5,8,11-12H2,1-3H3,(H2,21,24) QASOSVFTBTYBFY-UHFFFAOYSA-N 402897 US10329302, Example 45::US10793579, Example 45::US11702424, Example 45 Interleukin-1 receptor-associated kinase 4 [154-460] 1922 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402897&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414226 405262876 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296688 CC(C)Oc1cc2c(OC[C@H]3CNC[C@@H]3C(F)(F)F)nccc2cc1C(N)=O InChI=1S/C19H22F3N3O3/c1-10(2)28-16-6-13-11(5-14(16)17(23)26)3-4-25-18(13)27-9-12-7-24-8-15(12)19(20,21)22/h3-6,10,12,15,24H,7-9H2,1-2H3,(H2,23,26)/t12-,15+/m1/s1 KDHQYEHFEDOTEY-DOMZBBRYSA-N 402898 US10329302, Example 46::US10793579, Example 46::US11702424, Example 46 Interleukin-1 receptor-associated kinase 4 [154-460] 237 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402898&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118424399 405262877 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296689 CC(C)Oc1cc2c(OC[C@H]3CNCCO3)nccc2cc1C(N)=O InChI=1S/C18H23N3O4/c1-11(2)25-16-8-14-12(7-15(16)17(19)22)3-4-21-18(14)24-10-13-9-20-5-6-23-13/h3-4,7-8,11,13,20H,5-6,9-10H2,1-2H3,(H2,19,22)/t13-/m1/s1 SYMLNGYLCIGOCJ-CYBMUJFWSA-N 402899 US10329302, Example 47::US10793579, Example 47::US11702424, Example 47 Interleukin-1 receptor-associated kinase 4 [154-460] 2786 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402899&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414159 405262878 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296690 CC(C)Oc1cc2c(OC[C@@H]3CCCNC3)nccc2cc1C(N)=O InChI=1S/C19H25N3O3/c1-12(2)25-17-9-15-14(8-16(17)18(20)23)5-7-22-19(15)24-11-13-4-3-6-21-10-13/h5,7-9,12-13,21H,3-4,6,10-11H2,1-2H3,(H2,20,23)/t13-/m1/s1 IHMJXFBIRRLHLD-CYBMUJFWSA-N 402900 US10329302, Example 48::US10793579, Example 48::US11702424, Example 48 Interleukin-1 receptor-associated kinase 4 [154-460] 366 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402900&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414714 405262879 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296691 CC(C)Oc1cc2c(OC[C@H]3CCNC3)nccc2cc1C(N)=O InChI=1S/C18H23N3O3/c1-11(2)24-16-8-14-13(7-15(16)17(19)22)4-6-21-18(14)23-10-12-3-5-20-9-12/h4,6-8,11-12,20H,3,5,9-10H2,1-2H3,(H2,19,22)/t12-/m0/s1 OBVVWQOJTUVMSB-LBPRGKRZSA-N 402902 US10329302, Example 49::US10793579, Example 49::US11702424, Example 49 Interleukin-1 receptor-associated kinase 4 [154-460] 451 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402902&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414496 405262881 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296692 CC(C)Oc1cc2c(OC[C@H]3CCNC3)ccnc2cc1C(N)=O InChI=1S/C18H23N3O3/c1-11(2)24-17-8-13-15(7-14(17)18(19)22)21-6-4-16(13)23-10-12-3-5-20-9-12/h4,6-8,11-12,20H,3,5,9-10H2,1-2H3,(H2,19,22)/t12-/m0/s1 RAPSKYRIRVMGIA-LBPRGKRZSA-N 402903 US10329302, Example 50::US10793579, Example 50::US11702424, Example 50 Interleukin-1 receptor-associated kinase 4 [154-460] 701 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402903&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414676 405262882 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296693 CC(C)Oc1cc2c(OC[C@@H]3CNCCO3)ccnc2cc1C(N)=O InChI=1S/C18H23N3O4/c1-11(2)25-17-8-13-15(7-14(17)18(19)22)21-4-3-16(13)24-10-12-9-20-5-6-23-12/h3-4,7-8,11-12,20H,5-6,9-10H2,1-2H3,(H2,19,22)/t12-/m0/s1 YSXORAWCPYTWBE-LBPRGKRZSA-N 402904 US10329302, Example 51::US10793579, Example 51::US11702424, Example 51 Interleukin-1 receptor-associated kinase 4 [154-460] 2412 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402904&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414558 405262883 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296694 CC(C)Oc1cc2c(OC3CCC33CCNCC3)ccnc2cc1C(N)=O InChI=1S/C21H27N3O3/c1-13(2)26-18-12-14-16(11-15(18)20(22)25)24-8-4-17(14)27-19-3-5-21(19)6-9-23-10-7-21/h4,8,11-13,19,23H,3,5-7,9-10H2,1-2H3,(H2,22,25) XHJDTDBJFBLKGM-UHFFFAOYSA-N 402905 US10329302, Example 52::US10793579, Example 52::US11702424, Example 52 Interleukin-1 receptor-associated kinase 4 [154-460] 4236 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402905&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414506 405262884 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296695 CC(C)Oc1cc2c(OC[C@H]3CNCCO3)ccnc2cc1C(N)=O InChI=1S/C18H23N3O4/c1-11(2)25-17-8-13-15(7-14(17)18(19)22)21-4-3-16(13)24-10-12-9-20-5-6-23-12/h3-4,7-8,11-12,20H,5-6,9-10H2,1-2H3,(H2,19,22)/t12-/m1/s1 YSXORAWCPYTWBE-GFCCVEGCSA-N 402906 US10329302, Example 53::US11702424, Example 53 Interleukin-1 receptor-associated kinase 4 [154-460] 2380 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402906&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414380 405262885 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296696 CC(C)Oc1cc2c(OCC3(F)CCNCC3)ccnc2cc1C(N)=O InChI=1S/C19H24FN3O3/c1-12(2)26-17-10-13-15(9-14(17)18(21)24)23-6-3-16(13)25-11-19(20)4-7-22-8-5-19/h3,6,9-10,12,22H,4-5,7-8,11H2,1-2H3,(H2,21,24) LCOLOTNWNYVMPO-UHFFFAOYSA-N 402907 US10329302, Example 54::US10793579, Example 54::US11702424, Example 54 Interleukin-1 receptor-associated kinase 4 [154-460] 2435 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402907&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414274 405262886 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296697 CC(C)Oc1cc2c(OC[C@@]3(C)CNC[C@@H]3C)ccnc2cc1C(N)=O InChI=1S/C20H27N3O3/c1-12(2)26-18-8-14-16(7-15(18)19(21)24)23-6-5-17(14)25-11-20(4)10-22-9-13(20)3/h5-8,12-13,22H,9-11H2,1-4H3,(H2,21,24)/t13-,20+/m0/s1 VWKCKDRHMLFMAF-RNODOKPDSA-N 402908 US10329302, Example 55::US10793579, Example 55::US11702424, Example 55 Interleukin-1 receptor-associated kinase 4 [154-460] 264 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402908&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414420 405262887 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296698 CC(C)Oc1cc2c(OCC3(C)CCNCC3)ccnc2cc1C(N)=O InChI=1S/C20H27N3O3/c1-13(2)26-18-11-14-16(10-15(18)19(21)24)23-7-4-17(14)25-12-20(3)5-8-22-9-6-20/h4,7,10-11,13,22H,5-6,8-9,12H2,1-3H3,(H2,21,24) CKFFFOZJJXBSQZ-UHFFFAOYSA-N 402909 US10329302, Example 56::US10793579, Example 56::US11702424, Example 56 Interleukin-1 receptor-associated kinase 4 [154-460] 1489 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402909&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414510 405262888 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296699 CC(C)Oc1cc2c(OC[C@H]3CNC(=O)O3)ccnc2cc1C(N)=O InChI=1S/C17H19N3O5/c1-9(2)24-15-6-11-13(5-12(15)16(18)21)19-4-3-14(11)23-8-10-7-20-17(22)25-10/h3-6,9-10H,7-8H2,1-2H3,(H2,18,21)(H,20,22)/t10-/m1/s1 GUCXSVVXURWGDX-SNVBAGLBSA-N 402910 US10329302, Example 57::US10793579, Example 57::US11702424, Example 57 Interleukin-1 receptor-associated kinase 4 [154-460] 5.80 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402910&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414450 405262889 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296700 CC(C)Oc1cc2c(OCC3(C)CCCNC3)ccnc2cc1C(N)=O InChI=1S/C20H27N3O3/c1-13(2)26-18-10-14-16(9-15(18)19(21)24)23-8-5-17(14)25-12-20(3)6-4-7-22-11-20/h5,8-10,13,22H,4,6-7,11-12H2,1-3H3,(H2,21,24) GXFVQEWSWMVECQ-UHFFFAOYSA-N 402911 US10329302, Example 58::US10793579, Example 58::US11702424, Example 58 Interleukin-1 receptor-associated kinase 4 [154-460] 144 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402911&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414549 405262890 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296701 CC(C)Oc1cc2c(OCC3CCCNC3)ccnc2cc1C(N)=O InChI=1S/C19H25N3O3/c1-12(2)25-18-9-14-16(8-15(18)19(20)23)22-7-5-17(14)24-11-13-4-3-6-21-10-13/h5,7-9,12-13,21H,3-4,6,10-11H2,1-2H3,(H2,20,23) LGWAIKZDEAAWBY-UHFFFAOYSA-N 402718 US10329302, Example 4::US10329302, Example 59::US10793579, Example 59::US11702424, Example 59 Interleukin-1 receptor-associated kinase 4 [154-460] 243 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402718&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118424400 405262697 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296703 CC(C)Oc1cc2c(OC[C@H]3CCCN3C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C21H24N4O4/c1-13(2)29-18-11-16-14(10-17(18)20(23)27)6-8-24-21(16)28-12-15-4-3-9-25(15)19(26)5-7-22/h6,8,10-11,13,15H,3-5,9,12H2,1-2H3,(H2,23,27)/t15-/m1/s1 HFHXWRQSVHNKRP-OAHLLOKOSA-N 402914 US10329302, Example 61::US10793579, Example 61::US11702424, Example 61 Interleukin-1 receptor-associated kinase 4 [154-460] 249 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402914&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414592 405262892 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296704 CC(C)Oc1cc2c(OCC3CCN(CC3)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C22H26N4O4/c1-14(2)30-19-12-17-16(11-18(19)21(24)28)4-8-25-22(17)29-13-15-5-9-26(10-6-15)20(27)3-7-23/h4,8,11-12,14-15H,3,5-6,9-10,13H2,1-2H3,(H2,24,28) DFCJBKMSYIWNCU-UHFFFAOYSA-N 402915 US10329302, Example 62::US10793579, Example 62::US11702424, Example 62 Interleukin-1 receptor-associated kinase 4 [154-460] 1286 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402915&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414481 405262893 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296705 CC(C)Oc1cc2c(OC[C@@H]3CCCN3C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C21H24N4O4/c1-13(2)29-18-11-16-14(10-17(18)20(23)27)6-8-24-21(16)28-12-15-4-3-9-25(15)19(26)5-7-22/h6,8,10-11,13,15H,3-5,9,12H2,1-2H3,(H2,23,27)/t15-/m0/s1 HFHXWRQSVHNKRP-HNNXBMFYSA-N 402916 US10329302, Example 63::US10793579, Example 63::US11702424, Example 63 Interleukin-1 receptor-associated kinase 4 [154-460] 252 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402916&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414691 405262894 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296706 CC(C)Oc1cc2c(OC[C@H]3COCCN3C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C21H24N4O5/c1-13(2)30-18-10-16-14(9-17(18)20(23)27)4-6-24-21(16)29-12-15-11-28-8-7-25(15)19(26)3-5-22/h4,6,9-10,13,15H,3,7-8,11-12H2,1-2H3,(H2,23,27)/t15-/m1/s1 UOQYLSPUEAQZHA-OAHLLOKOSA-N 402917 US10329302, Example 64::US10793579, Example 64::US11702424, Example 64 Interleukin-1 receptor-associated kinase 4 [154-460] 641 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402917&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414559 405262895 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296707 CC(C)Oc1cc2c(OCC3(CCCC3)NC(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C22H26N4O4/c1-14(2)30-18-12-16-15(11-17(18)20(24)28)6-10-25-21(16)29-13-22(7-3-4-8-22)26-19(27)5-9-23/h6,10-12,14H,3-5,7-8,13H2,1-2H3,(H2,24,28)(H,26,27) ASBXIVDPGLCCRJ-UHFFFAOYSA-N 402918 US10329302, Example 65::US10793579, Example 65::US11702424, Example 65 Interleukin-1 receptor-associated kinase 4 [154-460] 563 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402918&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414211 405262896 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296708 CC(C)Oc1cc2c(OC[C@H]3CCN(C3)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C21H24N4O4/c1-13(2)29-18-10-16-15(9-17(18)20(23)27)4-7-24-21(16)28-12-14-5-8-25(11-14)19(26)3-6-22/h4,7,9-10,13-14H,3,5,8,11-12H2,1-2H3,(H2,23,27)/t14-/m0/s1 ZDIWCOHSBFKBLG-AWEZNQCLSA-N 402919 US10329302, Example 66::US10793579, Example 66::US11702424, Example 66 Interleukin-1 receptor-associated kinase 4 [154-460] 255 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402919&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414008 405262897 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296709 CC(C)Oc1cc2c(OC[C@@H]3CCCN(C3)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C22H26N4O4/c1-14(2)30-19-11-17-16(10-18(19)21(24)28)6-8-25-22(17)29-13-15-4-3-9-26(12-15)20(27)5-7-23/h6,8,10-11,14-15H,3-5,9,12-13H2,1-2H3,(H2,24,28)/t15-/m1/s1 XQQBOPGWVRNKRR-OAHLLOKOSA-N 402920 US10329302, Example 67::US10793579, Example 67::US11702424, Example 67 Interleukin-1 receptor-associated kinase 4 [154-460] 1730 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402920&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414246 405262898 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296710 CC(C)Oc1cc2c(O[C@@H]3C[C@H]4C[C@@H]3CN(C4)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C23H26N4O4/c1-13(2)30-20-10-17-15(9-18(20)22(25)29)4-6-26-23(17)31-19-8-14-7-16(19)12-27(11-14)21(28)3-5-24/h4,6,9-10,13-14,16,19H,3,7-8,11-12H2,1-2H3,(H2,25,29)/t14-,16-,19-/m1/s1 ZYSCTLOLUWCZLJ-IDHHARJASA-N 402922 US10329302, Example 68::US10793579, Example 68::US11702424, Example 68 Interleukin-1 receptor-associated kinase 4 [154-460] 320 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402922&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414704 405262900 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296712 CC(C)Oc1cc2c(OC[C@@H]3CCN(C3)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C21H24N4O4/c1-13(2)29-18-10-16-15(9-17(18)20(23)27)4-7-24-21(16)28-12-14-5-8-25(11-14)19(26)3-6-22/h4,7,9-10,13-14H,3,5,8,11-12H2,1-2H3,(H2,23,27)/t14-/m1/s1 ZDIWCOHSBFKBLG-CQSZACIVSA-N 402924 US10329302, Example 70::US10793579, Example 70::US11702424, Example 70 Interleukin-1 receptor-associated kinase 4 [154-460] 423 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402924&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414405 405262902 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296713 CC(C)Oc1cc2c(OC3CC[C@@H]4CN(C[C@H]34)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C23H26N4O4/c1-13(2)30-21-10-15-18(9-16(21)23(25)29)26-8-6-20(15)31-19-4-3-14-11-27(12-17(14)19)22(28)5-7-24/h6,8-10,13-14,17,19H,3-5,11-12H2,1-2H3,(H2,25,29)/t14-,17+,19?/m1/s1 YWBJNQMRPKDNRH-DMRSJCKZSA-N 402925 US10329302, Example 71::US10793579, Example 71::US11702424, Example 71 Interleukin-1 receptor-associated kinase 4 [154-460] 153 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402925&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414294 405262903 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296714 CC(C)Oc1cc2c(OC3C[C@@H]4CN[C@H]3C4)nccc2cc1C(N)=O InChI=1S/C19H23N3O3/c1-10(2)24-16-8-13-12(7-14(16)18(20)23)3-4-21-19(13)25-17-6-11-5-15(17)22-9-11/h3-4,7-8,10-11,15,17,22H,5-6,9H2,1-2H3,(H2,20,23)/t11-,15+,17?/m1/s1 YDHIVCKNHDIHRN-UXMYHRSUSA-N 402926 US10329302, Example 72::US10793579, Example 72::US11702424, Example 72 Interleukin-1 receptor-associated kinase 4 [154-460] 2625 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402926&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414632 405262904 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296715 CC(C)Oc1cc2c(OC[C@@H]3CCN3C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C20H22N4O4/c1-12(2)28-17-10-15-13(9-16(17)19(22)26)4-7-23-20(15)27-11-14-5-8-24(14)18(25)3-6-21/h4,7,9-10,12,14H,3,5,8,11H2,1-2H3,(H2,22,26)/t14-/m0/s1 KDTPBRALOJYZOG-AWEZNQCLSA-N 402927 US10329302, Example 73::US10793579, Example 73::US11702424, Example 73 Interleukin-1 receptor-associated kinase 4 [154-460] 1161 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402927&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414355 405262905 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296716 CC(C)Oc1cc2c(O[C@H]3C[C@@H]4C[C@H]3CN4C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C22H24N4O4/c1-12(2)29-19-10-16-13(8-17(19)21(24)28)4-6-25-22(16)30-18-9-15-7-14(18)11-26(15)20(27)3-5-23/h4,6,8,10,12,14-15,18H,3,7,9,11H2,1-2H3,(H2,24,28)/t14-,15-,18-/m0/s1 YFBUJWRVYFJCBZ-MPGHIAIKSA-N 402928 US10329302, Example 74::US10793579, Example 74::US11702424, Example 74 Interleukin-1 receptor-associated kinase 4 [154-460] 43.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402928&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414581 405262906 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296717 CC(C)Oc1cc2c(OC[C@@H]3CN(CCO3)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C21H24N4O5/c1-13(2)30-18-10-16-14(9-17(18)20(23)27)4-6-24-21(16)29-12-15-11-25(7-8-28-15)19(26)3-5-22/h4,6,9-10,13,15H,3,7-8,11-12H2,1-2H3,(H2,23,27)/t15-/m0/s1 KKXCHZXMZFGLDX-HNNXBMFYSA-N 402929 US10329302, Example 75::US10793579, Example 75::US11702424, Example 75 Interleukin-1 receptor-associated kinase 4 [154-460] 4039 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402929&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414767 405262907 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296718 CC(C)Oc1cc2c(OCC3(F)CCN(CC3)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C22H25FN4O4/c1-14(2)31-18-12-16-15(11-17(18)20(25)29)4-8-26-21(16)30-13-22(23)5-9-27(10-6-22)19(28)3-7-24/h4,8,11-12,14H,3,5-6,9-10,13H2,1-2H3,(H2,25,29) ZBCNEMVRCSTDDG-UHFFFAOYSA-N 402930 US10329302, Example 76::US10793579, Example 76::US11702424, Example 76 Interleukin-1 receptor-associated kinase 4 [154-460] 1721 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402930&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414857 405262908 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296719 CC(C)Oc1cc2c(OC[C@@]34C[C@@H]3CN(C4)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C22H24N4O4/c1-13(2)30-18-8-16-14(7-17(18)20(24)28)4-6-25-21(16)29-12-22-9-15(22)10-26(11-22)19(27)3-5-23/h4,6-8,13,15H,3,9-12H2,1-2H3,(H2,24,28)/t15-,22+/m1/s1 BSRPDZJURUUOHQ-QRQCRPRQSA-N 402931 US10329302, Example 77::US10793579, Example 77::US11702424, Example 77 Interleukin-1 receptor-associated kinase 4 [154-460] 468 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402931&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414063 405262909 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296720 CC(C)Oc1cc2c(OC[C@H]3CN(CCO3)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C21H24N4O5/c1-13(2)30-18-10-16-14(9-17(18)20(23)27)4-6-24-21(16)29-12-15-11-25(7-8-28-15)19(26)3-5-22/h4,6,9-10,13,15H,3,7-8,11-12H2,1-2H3,(H2,23,27)/t15-/m1/s1 KKXCHZXMZFGLDX-OAHLLOKOSA-N 402932 US10329302, Example 78::US10793579, Example 78::US11702424, Example 78 Interleukin-1 receptor-associated kinase 4 [154-460] 4743 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402932&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414431 405262910 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296721 CC(C)Oc1cc2c(O[C@H]3CC[C@@H]4CN(C[C@H]34)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C23H26N4O4/c1-13(2)30-20-10-16-14(9-17(20)22(25)29)6-8-26-23(16)31-19-4-3-15-11-27(12-18(15)19)21(28)5-7-24/h6,8-10,13,15,18-19H,3-5,11-12H2,1-2H3,(H2,25,29)/t15-,18+,19+/m1/s1 QHFJFVWMQOMMPR-MNEFBYGVSA-N 402933 US10329302, Example 79::US10793579, Example 79::US11702424, Example 79 Interleukin-1 receptor-associated kinase 4 [154-460] 457 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402933&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414163 405262911 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296722 CC[C@H]1CN(C[C@@H]1COc1nccc2cc(C(N)=O)c(OC(C)C)cc12)C(=O)CC#N InChI=1S/C23H28N4O4/c1-4-15-11-27(21(28)5-7-24)12-17(15)13-30-23-18-10-20(31-14(2)3)19(22(25)29)9-16(18)6-8-26-23/h6,8-10,14-15,17H,4-5,11-13H2,1-3H3,(H2,25,29)/t15-,17+/m0/s1 CVZQAWZOXSOTAZ-DOTOQJQBSA-N 402934 US10329302, Example 80::US10793579, Example 80::US11702424, Example 80 Interleukin-1 receptor-associated kinase 4 [154-460] 333 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402934&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414823 405262912 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296723 CC(C)Oc1cc2c(O[C@H]3C[C@@H]4C[C@H]3CN(C4)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C23H26N4O4/c1-13(2)30-20-10-17-15(9-18(20)22(25)29)4-6-26-23(17)31-19-8-14-7-16(19)12-27(11-14)21(28)3-5-24/h4,6,9-10,13-14,16,19H,3,7-8,11-12H2,1-2H3,(H2,25,29)/t14-,16-,19-/m0/s1 ZYSCTLOLUWCZLJ-QOKNQOGYSA-N 402935 US10329302, Example 81::US10793579, Example 81::US11702424, Example 81 Interleukin-1 receptor-associated kinase 4 [154-460] 479 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402935&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414257 405262913 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296724 CC(C)Oc1cc2c(OCC3(C)CCN(C3)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C22H26N4O4/c1-14(2)30-18-11-16-15(10-17(18)20(24)28)5-8-25-21(16)29-13-22(3)6-9-26(12-22)19(27)4-7-23/h5,8,10-11,14H,4,6,9,12-13H2,1-3H3,(H2,24,28) RRNQMXDCZIEQBP-UHFFFAOYSA-N 402936 US10329302, Example 82::US10793579, Example 82::US11702424, Example 82 Interleukin-1 receptor-associated kinase 4 [154-460] 969 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402936&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414235 405262914 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296725 CC(C)Oc1cc2c(OC[C@@H]3COCCN3C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C21H24N4O5/c1-13(2)30-18-10-16-14(9-17(18)20(23)27)4-6-24-21(16)29-12-15-11-28-8-7-25(15)19(26)3-5-22/h4,6,9-10,13,15H,3,7-8,11-12H2,1-2H3,(H2,23,27)/t15-/m0/s1 UOQYLSPUEAQZHA-HNNXBMFYSA-N 402937 US10329302, Example 83::US10793579, Example 83::US11702424, Example 83 Interleukin-1 receptor-associated kinase 4 [154-460] 175 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402937&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414198 405262915 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296726 CO[C@H]1CN(C[C@@H]1COc1nccc2cc(C(N)=O)c(OC(C)C)cc12)C(=O)CC#N InChI=1S/C22H26N4O5/c1-13(2)31-18-9-16-14(8-17(18)21(24)28)5-7-25-22(16)30-12-15-10-26(11-19(15)29-3)20(27)4-6-23/h5,7-9,13,15,19H,4,10-12H2,1-3H3,(H2,24,28)/t15-,19+/m1/s1 CFTZHMLCLQCTRT-BEFAXECRSA-N 402938 US10329302, Example 84::US10793579, Example 84::US11702424, Example 84 Interleukin-1 receptor-associated kinase 4 [154-460] 534 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402938&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414811 405262916 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296727 CC(C)Oc1cc2c(OC[C@H]3CN(C[C@@H]3C)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C22H26N4O4/c1-13(2)30-19-9-17-15(8-18(19)21(24)28)5-7-25-22(17)29-12-16-11-26(10-14(16)3)20(27)4-6-23/h5,7-9,13-14,16H,4,10-12H2,1-3H3,(H2,24,28)/t14-,16+/m0/s1 RZQBWCNBLJENNY-GOEBONIOSA-N 402939 US10329302, Example 85::US10793579, Example 85::US11702424, Example 85 Interleukin-1 receptor-associated kinase 4 [154-460] 610 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402939&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414679 405262917 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296728 CC(C)Oc1cc2c(OCC3(C)CCN(CC3)C(=O)CC#N)nccc2cc1C(N)=O InChI=1S/C23H28N4O4/c1-15(2)31-19-13-17-16(12-18(19)21(25)29)5-9-26-22(17)30-14-23(3)6-10-27(11-7-23)20(28)4-8-24/h5,9,12-13,15H,4,6-7,10-11,14H2,1-3H3,(H2,25,29) ZTVDLJPOKYZVSP-UHFFFAOYSA-N 402940 US10329302, Example 86::US10793579, Example 86::US11702424, Example 86 Interleukin-1 receptor-associated kinase 4 [154-460] 216 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402940&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414686 405262918 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296729 CC(C)Oc1cc2c(OC[C@H]3[C@@H]4CN(C[C@H]34)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C22H24N4O4/c1-12(2)30-20-8-13-18(7-14(20)22(24)28)25-6-4-19(13)29-11-17-15-9-26(10-16(15)17)21(27)3-5-23/h4,6-8,12,15-17H,3,9-11H2,1-2H3,(H2,24,28)/t15-,16+,17+ KVMSITQIYUXLAA-FVQHAEBGSA-N 402941 US10329302, Example 87::US10793579, Example 87::US11702424, Example 87 Interleukin-1 receptor-associated kinase 4 [154-460] 2621 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402941&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414466 405262919 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296730 CC(C)Oc1cc2c(OC[C@H]3CN(C[C@@H]3C)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C22H26N4O4/c1-13(2)30-20-9-16-18(8-17(20)22(24)28)25-7-5-19(16)29-12-15-11-26(10-14(15)3)21(27)4-6-23/h5,7-9,13-15H,4,10-12H2,1-3H3,(H2,24,28)/t14-,15+/m0/s1 RMHRDXQOWBKQED-LSDHHAIUSA-N 402942 US10329302, Example 88::US10793579, Example 88::US11702424, Example 88 Interleukin-1 receptor-associated kinase 4 [154-460] 292 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402942&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414600 405262920 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296731 CC(C)Oc1cc2c(O[C@@H]3C[C@H]4C[C@@H]3CN(C4)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C23H26N4O4/c1-13(2)30-21-10-16-18(9-17(21)23(25)29)26-6-4-19(16)31-20-8-14-7-15(20)12-27(11-14)22(28)3-5-24/h4,6,9-10,13-15,20H,3,7-8,11-12H2,1-2H3,(H2,25,29)/t14-,15-,20-/m1/s1 BFWYQVFMKZNCFH-STXHMFSFSA-N 402943 US10329302, Example 89::US10793579, Example 89::US11702424, Example 89 Interleukin-1 receptor-associated kinase 4 [154-460] 395 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402943&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414265 405262921 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296732 CC(C)Oc1cc2c(OC[C@@]34C[C@@H]3CN(C4)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C22H24N4O4/c1-13(2)30-19-8-15-17(7-16(19)21(24)28)25-6-4-18(15)29-12-22-9-14(22)10-26(11-22)20(27)3-5-23/h4,6-8,13-14H,3,9-12H2,1-2H3,(H2,24,28)/t14-,22+/m1/s1 UERWATHHAPICNY-PEBXRYMYSA-N 402944 US10329302, Example 90::US10329302, Example 94::US10793579, Example 94::US11702424, Example 94 Interleukin-1 receptor-associated kinase 4 [154-460] 438 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402944&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414739 405262922 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296733 CC(C)Oc1cc2c(OCC3(C)CCN(CC3)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C23H28N4O4/c1-15(2)31-20-13-16-18(12-17(20)22(25)29)26-9-5-19(16)30-14-23(3)6-10-27(11-7-23)21(28)4-8-24/h5,9,12-13,15H,4,6-7,10-11,14H2,1-3H3,(H2,25,29) HGZAGRNWPSPOFA-UHFFFAOYSA-N 402945 US10329302, Example 91::US10793579, Example 91::US11702424, Example 91 Interleukin-1 receptor-associated kinase 4 [154-460] 489 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402945&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414678 405262923 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296734 CC(C)Oc1cc2c(O[C@H]3C[C@@H]4C[C@H]3CN(C4)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C23H26N4O4/c1-13(2)30-21-10-16-18(9-17(21)23(25)29)26-6-4-19(16)31-20-8-14-7-15(20)12-27(11-14)22(28)3-5-24/h4,6,9-10,13-15,20H,3,7-8,11-12H2,1-2H3,(H2,25,29)/t14-,15-,20-/m0/s1 BFWYQVFMKZNCFH-AVYPCKFXSA-N 465986 US10793579, Example 92::US11702424, Example 92 Interleukin-1 receptor-associated kinase 4 [154-460] 473 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=465986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=465986&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414368 441575694 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296735 CC(C)Oc1cc2c(OC[C@H]3CCCN(C3)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C22H26N4O4/c1-14(2)30-20-11-16-18(10-17(20)22(24)28)25-8-6-19(16)29-13-15-4-3-9-26(12-15)21(27)5-7-23/h6,8,10-11,14-15H,3-5,9,12-13H2,1-2H3,(H2,24,28)/t15-/m0/s1 GHIURNOKVSJINX-HNNXBMFYSA-N 402947 US10329302, Example 93::US10793579, Example 93::US11702424, Example 93 Interleukin-1 receptor-associated kinase 4 [154-460] 1520 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402947&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414666 405262925 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296736 CC(C)Oc1cc2c(OC[C@@]34C[C@@H]3CN(C4)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C22H24N4O4/c1-13(2)30-19-8-15-17(7-16(19)21(24)28)25-6-4-18(15)29-12-22-9-14(22)10-26(11-22)20(27)3-5-23/h4,6-8,13-14H,3,9-12H2,1-2H3,(H2,24,28)/t14-,22+/m1/s1 UERWATHHAPICNY-PEBXRYMYSA-N 402944 US10329302, Example 90::US10329302, Example 94::US10793579, Example 94::US11702424, Example 94 Interleukin-1 receptor-associated kinase 4 [154-460] 526 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402944&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414739 405262922 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296737 CC(C)Oc1cc2c(OCC3(F)CCN(CC3)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C22H25FN4O4/c1-14(2)31-19-12-15-17(11-16(19)21(25)29)26-8-4-18(15)30-13-22(23)5-9-27(10-6-22)20(28)3-7-24/h4,8,11-12,14H,3,5-6,9-10,13H2,1-2H3,(H2,25,29) BRBXYPRKJOWOCY-UHFFFAOYSA-N 402949 US10329302, Example 95::US10793579, Example 95::US11702424, Example 95 Interleukin-1 receptor-associated kinase 4 [154-460] 3167 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402949&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414471 405262926 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296738 CO[C@H]1CN(C[C@@H]1COc1ccnc2cc(C(N)=O)c(OC(C)C)cc12)C(=O)CC#N InChI=1S/C22H26N4O5/c1-13(2)31-19-9-15-17(8-16(19)22(24)28)25-7-5-18(15)30-12-14-10-26(11-20(14)29-3)21(27)4-6-23/h5,7-9,13-14,20H,4,10-12H2,1-3H3,(H2,24,28)/t14-,20+/m1/s1 VYBXPAOLECAJGF-VLIAUNLRSA-N 402950 US10329302, Example 96::US10793579, Example 96::US11702424, Example 96 Interleukin-1 receptor-associated kinase 4 [154-460] 301 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402950&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414735 405262927 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296739 CC(C)Oc1cc2c(OC[C@@H]3CCCN(C3)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C22H26N4O4/c1-14(2)30-20-11-16-18(10-17(20)22(24)28)25-8-6-19(16)29-13-15-4-3-9-26(12-15)21(27)5-7-23/h6,8,10-11,14-15H,3-5,9,12-13H2,1-2H3,(H2,24,28)/t15-/m1/s1 GHIURNOKVSJINX-OAHLLOKOSA-N 402951 US10329302, Example 97::US10793579, Example 97::US11702424, Example 97 Interleukin-1 receptor-associated kinase 4 [154-460] 2741 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402951&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414292 405262928 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296740 CC(C)Oc1cc2c(OC[C@@H]3CN(CCO3)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C21H24N4O5/c1-13(2)30-19-10-15-17(9-16(19)21(23)27)24-6-4-18(15)29-12-14-11-25(7-8-28-14)20(26)3-5-22/h4,6,9-10,13-14H,3,7-8,11-12H2,1-2H3,(H2,23,27)/t14-/m0/s1 FQXURJQFZYMACA-AWEZNQCLSA-N 402952 US10329302, Example 98::US10793579, Example 98::US11702424, Example 98 Interleukin-1 receptor-associated kinase 4 [154-460] 575 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402952&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414700 405262929 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296741 CC(C)Oc1cc2c(OCC3CCCCN3C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C22H26N4O4/c1-14(2)30-20-12-16-18(11-17(20)22(24)28)25-9-7-19(16)29-13-15-5-3-4-10-26(15)21(27)6-8-23/h7,9,11-12,14-15H,3-6,10,13H2,1-2H3,(H2,24,28) HASYWQCCTPWPAH-UHFFFAOYSA-N 402953 US10329302, Example 99::US10793579, Example 99::US11702424, Example 99 Interleukin-1 receptor-associated kinase 4 [154-460] 524 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402953&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414840 405262930 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296742 CC(C)Oc1cc2c(OCC3CCN(CC3)C(=O)CC#N)ccnc2cc1C(N)=O InChI=1S/C22H26N4O4/c1-14(2)30-20-12-16-18(11-17(20)22(24)28)25-8-4-19(16)29-13-15-5-9-26(10-6-15)21(27)3-7-23/h4,8,11-12,14-15H,3,5-6,9-10,13H2,1-2H3,(H2,24,28) CABUZYWFNLUXRH-UHFFFAOYSA-N 402954 US10329302, Example 100::US10793579, Example 100::US11702424, Example 100 Interleukin-1 receptor-associated kinase 4 [154-460] 482 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402954&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414802 405262931 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296743 CC(C)Oc1cc2c(O[C@H]3C[C@@H]4C[C@H]3CN4)nccc2cc1C(N)=O InChI=1S/C19H23N3O3/c1-10(2)24-17-8-14-11(6-15(17)18(20)23)3-4-21-19(14)25-16-7-13-5-12(16)9-22-13/h3-4,6,8,10,12-13,16,22H,5,7,9H2,1-2H3,(H2,20,23)/t12-,13-,16-/m0/s1 LOTYDGTXUKYUPZ-XEZPLFJOSA-N 402955 US10329302, Example 101::US10793579, Example 101::US11702424, Example 101 Interleukin-1 receptor-associated kinase 4 [154-460] 1177 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402955&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414361 405262932 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296744 CC(C)Oc1cc2c(O[C@@H]3C[C@H]4C[C@@H]3CN4)nccc2cc1C(N)=O InChI=1S/C19H23N3O3/c1-10(2)24-17-8-14-11(6-15(17)18(20)23)3-4-21-19(14)25-16-7-13-5-12(16)9-22-13/h3-4,6,8,10,12-13,16,22H,5,7,9H2,1-2H3,(H2,20,23)/t12-,13-,16-/m1/s1 LOTYDGTXUKYUPZ-XJKCOSOUSA-N 402956 US10329302, Example 102::US10793579, Example 102::US11702424, Example 102 Interleukin-1 receptor-associated kinase 4 [154-460] 217 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402956&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414628 405262933 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296749 CC(C)Oc1cc2c(OC[C@@H]3CC(C)C(=O)N3)nccc2cc1C(N)=O InChI=1S/C19H23N3O4/c1-10(2)26-16-8-14-12(7-15(16)17(20)23)4-5-21-19(14)25-9-13-6-11(3)18(24)22-13/h4-5,7-8,10-11,13H,6,9H2,1-3H3,(H2,20,23)(H,22,24)/t11?,13-/m0/s1 TUXDVBCBOCZFGN-YUZLPWPTSA-N 402961 US10329302, Example 107::US10793579, Example 107::US11702424, Example 107 Interleukin-1 receptor-associated kinase 4 [154-460] 16.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402961&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414188 405262938 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296750 CC(C)Oc1cc2c(O[C@@H]3C[C@@H]4CN[C@H]3C4)nccc2cc1C(N)=O InChI=1S/C19H23N3O3/c1-10(2)24-16-8-13-12(7-14(16)18(20)23)3-4-21-19(13)25-17-6-11-5-15(17)22-9-11/h3-4,7-8,10-11,15,17,22H,5-6,9H2,1-2H3,(H2,20,23)/t11-,15+,17-/m1/s1 YDHIVCKNHDIHRN-XQAQDONZSA-N 402962 US10329302, Example 108::US10793579, Example 108::US11702424, Example 108 Interleukin-1 receptor-associated kinase 4 [154-460] 1867 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402962&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414306 405262939 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296751 CC(C)Oc1cc2c(O[C@H]3C[C@@H]4CN[C@H]3C4)nccc2cc1C(N)=O InChI=1S/C19H23N3O3/c1-10(2)24-16-8-13-12(7-14(16)18(20)23)3-4-21-19(13)25-17-6-11-5-15(17)22-9-11/h3-4,7-8,10-11,15,17,22H,5-6,9H2,1-2H3,(H2,20,23)/t11-,15+,17+/m1/s1 YDHIVCKNHDIHRN-PJQXDXOGSA-N 402963 US10329302, Example 109::US10793579, Example 109::US11702424, Example 109 Interleukin-1 receptor-associated kinase 4 [154-460] 1909 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402963&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414848 405262940 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296753 CC(C)Oc1cc2c(OCC3CNC(=O)C3)nccc2cc1C(N)=O InChI=1S/C18H21N3O4/c1-10(2)25-15-7-13-12(6-14(15)17(19)23)3-4-20-18(13)24-9-11-5-16(22)21-8-11/h3-4,6-7,10-11H,5,8-9H2,1-2H3,(H2,19,23)(H,21,22) MFFMBAYGGJMRBN-UHFFFAOYSA-N 402965 US10329302, Example 111::US10793579, Example 111::US11702424, Example 111 Interleukin-1 receptor-associated kinase 4 [154-460] 196 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402965&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414839 405262942 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296756 CC(C)Oc1cc2c(OC[C@@H]3CCNC3)cccc2cc1C(N)=O InChI=1S/C19H24N2O3/c1-12(2)24-18-9-15-14(8-16(18)19(20)22)4-3-5-17(15)23-11-13-6-7-21-10-13/h3-5,8-9,12-13,21H,6-7,10-11H2,1-2H3,(H2,20,22)/t13-/m1/s1 BQKZFHARXCADIE-CYBMUJFWSA-N 402968 US10329302, Example 115::US10793579, Example 115::US11702424, Example 115 Interleukin-1 receptor-associated kinase 4 [154-460] 61.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402968&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414077 405262945 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296758 CC(C)Oc1cc2c(OC[C@@H]3CCNC3)nccc2cc1C(N)=O InChI=1S/C18H23N3O3/c1-11(2)24-16-8-14-13(7-15(16)17(19)22)4-6-21-18(14)23-10-12-3-5-20-9-12/h4,6-8,11-12,20H,3,5,9-10H2,1-2H3,(H2,19,22)/t12-/m1/s1 OBVVWQOJTUVMSB-GFCCVEGCSA-N 402970 US10329302, Example 117::US10793579, Example 117::US11702424, Example 117 Interleukin-1 receptor-associated kinase 4 [154-460] 136 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402970&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414078 405262947 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296760 CC(C)Oc1cc2c(OC[C@@H]3CCN3)nccc2cc1C(N)=O InChI=1S/C17H21N3O3/c1-10(2)23-15-8-13-11(7-14(15)16(18)21)3-5-20-17(13)22-9-12-4-6-19-12/h3,5,7-8,10,12,19H,4,6,9H2,1-2H3,(H2,18,21)/t12-/m0/s1 LXUPNHIXRYCTOO-LBPRGKRZSA-N 402972 US10329302, Example 119::US10793579, Example 119::US11702424, Example 119 Interleukin-1 receptor-associated kinase 4 [154-460] 1429 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402972&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414161 405262949 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296771 CC(C)Oc1cc2c(O[C@@H]3CC[C@H]4CC(=O)N[C@@H]34)nccc2cc1C(N)=O InChI=1S/C20H23N3O4/c1-10(2)26-16-9-13-11(7-14(16)19(21)25)5-6-22-20(13)27-15-4-3-12-8-17(24)23-18(12)15/h5-7,9-10,12,15,18H,3-4,8H2,1-2H3,(H2,21,25)(H,23,24)/t12-,15+,18+/m0/s1 VNARQCQKSIMSRA-WBHUJUFNSA-N 402983 US10329302, Example 130::US10793579, Example 130::US11702424, Example 130 Interleukin-1 receptor-associated kinase 4 [154-460] 417 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402983&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414875 405262960 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296779 CC(C)Oc1cc2c(OCC3CCNC(=O)C3)nccc2cc1C(N)=O InChI=1S/C19H23N3O4/c1-11(2)26-16-9-14-13(8-15(16)18(20)24)4-6-22-19(14)25-10-12-3-5-21-17(23)7-12/h4,6,8-9,11-12H,3,5,7,10H2,1-2H3,(H2,20,24)(H,21,23) AXZFNDPOVZHIIO-UHFFFAOYSA-N 402991 US10329302, Example 138::US10793579, Example 138::US11702424, Example 138 Interleukin-1 receptor-associated kinase 4 [154-460] 1037 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402991&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414573 405262968 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296780 CC(C)Oc1cc2c(OC[C@@]34C[C@@H]3CNC4)nccc2cc1C(N)=O InChI=1S/C19H23N3O3/c1-11(2)25-16-6-14-12(5-15(16)17(20)23)3-4-22-18(14)24-10-19-7-13(19)8-21-9-19/h3-6,11,13,21H,7-10H2,1-2H3,(H2,20,23)/t13-,19+/m1/s1 LPMZEDIWGJMIEH-YJYMSZOUSA-N 402890 US10329302, Example 139::US10329302, Example 40::US10793579, Example 139::US11702424, Example 139 Interleukin-1 receptor-associated kinase 4 [154-460] 256 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402890&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414782 405262869 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296781 CC(C)Oc1cc2c(OC[C@]34C[C@H]3CNC4)nccc2cc1C(N)=O InChI=1S/C19H23N3O3/c1-11(2)25-16-6-14-12(5-15(16)17(20)23)3-4-22-18(14)24-10-19-7-13(19)8-21-9-19/h3-6,11,13,21H,7-10H2,1-2H3,(H2,20,23)/t13-,19+/m0/s1 LPMZEDIWGJMIEH-ORAYPTAESA-N 402993 US10329302, Example 140::US10793579, Example 140::US11702424, Example 140 Interleukin-1 receptor-associated kinase 4 [154-460] 84.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=402993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=402993&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414192 405262969 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296789 CC(C)Oc1cc2c(OC[C@@H]3CC(CO)C(=O)N3)nccc2cc1C(N)=O InChI=1S/C19H23N3O5/c1-10(2)27-16-7-14-11(6-15(16)17(20)24)3-4-21-19(14)26-9-13-5-12(8-23)18(25)22-13/h3-4,6-7,10,12-13,23H,5,8-9H2,1-2H3,(H2,20,24)(H,22,25)/t12?,13-/m0/s1 RPDFPKNJVMCACH-ABLWVSNPSA-N 403001 US10329302, Example 148::US10793579, Example 148::US11702424, Example 148 Interleukin-1 receptor-associated kinase 4 [154-460] 24.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=403001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=403001&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414440 405262977 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296799 CC(C)Oc1cc2c(OC[C@H]3COCCN3)nccc2cc1C(N)=O InChI=1S/C18H23N3O4/c1-11(2)25-16-8-14-12(7-15(16)17(19)22)3-4-21-18(14)24-10-13-9-23-6-5-20-13/h3-4,7-8,11,13,20H,5-6,9-10H2,1-2H3,(H2,19,22)/t13-/m1/s1 LWDVQSVCPIDGJT-CYBMUJFWSA-N 403011 US10329302, Example 158::US11702424, Example 158 Interleukin-1 receptor-associated kinase 4 [154-460] 1443 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=403011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=403011&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414430 405262987 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296800 CC(C)Oc1cc2c(OCC3CCCN3)nccc2cc1C(N)=O InChI=1S/C18H23N3O3/c1-11(2)24-16-9-14-12(8-15(16)17(19)22)5-7-21-18(14)23-10-13-4-3-6-20-13/h5,7-9,11,13,20H,3-4,6,10H2,1-2H3,(H2,19,22) IBVBHRGRNBEHPT-UHFFFAOYSA-N 403012 US10329302, Example 159::US10793579, Example 159::US11702424, Example 159 Interleukin-1 receptor-associated kinase 4 [154-460] 3377 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=403012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=403012&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414181 405262988 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296801 CC(C)Oc1cc2c(OC[C@@H]3COCCN3)nccc2cc1C(N)=O InChI=1S/C18H23N3O4/c1-11(2)25-16-8-14-12(7-15(16)17(19)22)3-4-21-18(14)24-10-13-9-23-6-5-20-13/h3-4,7-8,11,13,20H,5-6,9-10H2,1-2H3,(H2,19,22)/t13-/m0/s1 LWDVQSVCPIDGJT-ZDUSSCGKSA-N 403013 US10329302, Example 160::US10793579, Example 160::US11702424, Example 160 Interleukin-1 receptor-associated kinase 4 [154-460] 151 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=403013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=403013&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414416 405262989 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296802 CC(C)Oc1cc2c(OC[C@]34C[C@H]3CCNC4)nccc2cc1C(N)=O InChI=1S/C20H25N3O3/c1-12(2)26-17-8-15-13(7-16(17)18(21)24)3-6-23-19(15)25-11-20-9-14(20)4-5-22-10-20/h3,6-8,12,14,22H,4-5,9-11H2,1-2H3,(H2,21,24)/t14-,20-/m1/s1 GEVKDVZUXRBHDI-JLTOFOAXSA-N 403014 US10329302, Example 161::US10793579, Example 161::US11702424, Example 161 Interleukin-1 receptor-associated kinase 4 [154-460] 88.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=403014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=403014&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414100 405262990 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296803 CC(C)Oc1cc2c(OC[C@@]34C[C@@H]3CCNC4)nccc2cc1C(N)=O InChI=1S/C20H25N3O3/c1-12(2)26-17-8-15-13(7-16(17)18(21)24)3-6-23-19(15)25-11-20-9-14(20)4-5-22-10-20/h3,6-8,12,14,22H,4-5,9-11H2,1-2H3,(H2,21,24)/t14-,20-/m0/s1 GEVKDVZUXRBHDI-XOBRGWDASA-N 403015 US10329302, Example 162::US10793579, Example 162::US11702424, Example 162 Interleukin-1 receptor-associated kinase 4 [154-460] 35.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=403015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=403015&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414291 405262991 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296808 CC(C)Oc1cc2c(OC[C@H]3NC(=O)[C@@H]4OC(C)(C)O[C@H]34)nccc2cc1C(N)=O InChI=1S/C21H25N3O6/c1-10(2)28-15-8-12-11(7-13(15)18(22)25)5-6-23-20(12)27-9-14-16-17(19(26)24-14)30-21(3,4)29-16/h5-8,10,14,16-17H,9H2,1-4H3,(H2,22,25)(H,24,26)/t14-,16-,17-/m1/s1 DUHLEWSSGCYAPF-DJIMGWMZSA-N 403020 US10329302, Example 167::US10793579, Example 167::US11702424, Example 167 Interleukin-1 receptor-associated kinase 4 [154-460] 19.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=403020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=403020&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414752 405262996 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296815 CC(C)Oc1cc2c(OC[C@@]34C[C@@H]3C(=O)NC4)nccc2cc1C(N)=O InChI=1S/C19H21N3O4/c1-10(2)26-15-6-12-11(5-13(15)16(20)23)3-4-21-18(12)25-9-19-7-14(19)17(24)22-8-19/h3-6,10,14H,7-9H2,1-2H3,(H2,20,23)(H,22,24)/t14-,19+/m1/s1 GYIYDDOJPVMQAW-KUHUBIRLSA-N 403027 US10329302, Example 175::US10793579, Example 175::US11702424, Example 175 Interleukin-1 receptor-associated kinase 4 [154-460] 101 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=403027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=403027&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414167 405263003 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296824 CC(C)Oc1cc2c(OC[C@@H]3C[C@](O)(CC(F)(F)F)C(=O)N3)nccc2cc1C(N)=O InChI=1S/C20H22F3N3O5/c1-10(2)31-15-6-13-11(5-14(15)16(24)27)3-4-25-17(13)30-8-12-7-19(29,18(28)26-12)9-20(21,22)23/h3-6,10,12,29H,7-9H2,1-2H3,(H2,24,27)(H,26,28)/t12-,19-/m0/s1 RWCOAQPWVXSJOZ-BUXKBTBVSA-N 403036 US10329302, Example 184::US10793579, Example 184::US11702424, Example 184 Interleukin-1 receptor-associated kinase 4 [154-460] 60.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=403036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=403036&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414118 405263012 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296831 CC(C)Oc1cc2c(OCC3CCNC3)nccc2cc1C(N)=O InChI=1S/C18H23N3O3/c1-11(2)24-16-8-14-13(7-15(16)17(19)22)4-6-21-18(14)23-10-12-3-5-20-9-12/h4,6-8,11-12,20H,3,5,9-10H2,1-2H3,(H2,19,22) OBVVWQOJTUVMSB-UHFFFAOYSA-N 403043 US10329302, Example 191::US10793579, Example 191::US11702424, Example 191 Interleukin-1 receptor-associated kinase 4 [154-460] 252 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=403043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=403043&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414745 405263019 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296857 COc1cc2c(OC[C@@H]3NC(=O)CC3(C)C)nccc2cc1C(N)=O InChI=1S/C18H21N3O4/c1-18(2)8-15(22)21-14(18)9-25-17-11-7-13(24-3)12(16(19)23)6-10(11)4-5-20-17/h4-7,14H,8-9H2,1-3H3,(H2,19,23)(H,21,22)/t14-/m0/s1 NAGCOGHPIBOEOI-AWEZNQCLSA-N 403069 US10329302, Example 222::US10793579, Example 222::US11702424, Example 222 Interleukin-1 receptor-associated kinase 4 [154-460] 1870 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=403069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=403069&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414271 405263044 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 1296858 CC(C)Oc1cc2c(OC[C@@H]3NC(=O)CC3(C)C)nccc2cc1C(N)=O InChI=1S/C20H25N3O4/c1-11(2)27-15-8-13-12(7-14(15)18(21)25)5-6-22-19(13)26-10-16-20(3,4)9-17(24)23-16/h5-8,11,16H,9-10H2,1-4H3,(H2,21,25)(H,23,24)/t16-/m0/s1 CVVWERHXGLFUQU-INIZCTEOSA-N 403070 US10329302, Example 223::US10793579, Example 223::US11702424, Example 223 Interleukin-1 receptor-associated kinase 4 [154-460] 15.0 US Patent 10.7270/Q27D308N US11702424 Trzupek, JD; Lee, KL; Bunnage, ME; Han, S; Hepworth, D; Lovering, FE; Mathias, JP; Papaioannou, N; Pierce, BS; Strohbach, JW; Wright, SW; Zapf, CW; Gavrin, LK; Lee, A; Anderson, DR; Curran, KJ; Dehnhardt, CM; Saiah, E; Goldberg, JA; Wang, X; Huang, H; Vargas, R; Lowe, MD; Patny, A Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=403070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1458&target=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=403070&enzyme=Interleukin-1+receptor-associated+kinase+4+%5B154-460%5D&column=ki&startPg=0&Increment=50&submit=Search 118414134 405263045 1 ENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS