BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 25350 NS(=O)(=O)c1ccc2CCNCc2c1 InChI=1S/C9H12N2O2S/c10-14(12,13)9-2-1-7-3-4-11-6-8(7)5-9/h1-2,5,11H,3-4,6H2,(H2,10,12,13) UGLLZXSYRBMNOS-UHFFFAOYSA-N 13017 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide::CHEMBL26717::SKF 29661 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 100000 7.7 25.00 C Curated from the literature by BindingDB 10.1021/jm0205752 10.7270/Q21R6NRH 14695818 aid1797149 McMillan, FM; Archbold, J; McLeish, MJ; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL University of Queensland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13017&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search SKF 1HNN 5226 46513441 CHEMBL26717 DB03468 ZINC20397736 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 25351 Ic1ccc2CCNCc2c1 InChI=1S/C9H10IN/c10-9-2-1-7-3-4-11-6-8(7)5-9/h1-2,5,11H,3-4,6H2 FFCFXJXBXUOFIU-UHFFFAOYSA-N 14060 7-Iodo-1,2,3,4-tetrahydroisoquinoline::CHEMBL26828::tetrahydroisoquinoline (THIQ) deriv. 2 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 220 7.7 25.00 C Curated from the literature by BindingDB 10.1021/jm0205752 10.7270/Q21R6NRH 14695818 aid1797149 McMillan, FM; Archbold, J; McLeish, MJ; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL University of Queensland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14060&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search IDI 1N7J 5288606 46509434 CHEMBL26828 DB03824 ZINC12503940 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 25352 Clc1ccc2CCCNCc2c1Cl InChI=1S/C10H11Cl2N/c11-9-4-3-7-2-1-5-13-6-8(7)10(9)12/h3-4,13H,1-2,5-6H2 IADAQXMUWITWNG-UHFFFAOYSA-N 14061 8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine::CHEMBL38681::LY134046::tetrahydrobenzazepine (THBA) deriv. Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 4500 7.7 25.00 C Curated from the literature by BindingDB 10.1021/jm0205752 10.7270/Q21R6NRH 14695818 aid1797149 McMillan, FM; Archbold, J; McLeish, MJ; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL University of Queensland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14061&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search LY1 1N7I 121938 46514425 CHEMBL38681 DB04273 6631 ZINC02047666 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 25353 Clc1ccc2CCNCc2c1Cl InChI=1S/C9H9Cl2N/c10-8-2-1-6-3-4-12-5-7(6)9(8)11/h1-2,12H,3-5H2 WFPUBEDBBOGGIQ-UHFFFAOYSA-N 13014 7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydrochloride::7,8-dichloro-1,2,3,4-tetrahydroisoquinoline::CHEMBL287837::CHEMBL541797::SKF 64139::tetrahydroisoquinoline (THIQ) analogue Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 21 7.7 25.00 C Curated from the literature by BindingDB 10.1021/jm0205752 10.7270/Q21R6NRH 14695818 aid1797149 McMillan, FM; Archbold, J; McLeish, MJ; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL University of Queensland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13014&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search SKA 1YZ3 123920 46509415 160129 CHEMBL541797CHEMBL287837 DB08550 ZINC24714117 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162034 COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12 InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16-,19+/m0/s1 GRTOGORTSDXSFK-BMYCAMMWSA-N 50030622 (7aS,8S,11aS,12aR)-8-Methyl-5,6,7a,8,11a,12,12a,13-octahydro-7H-9-oxa-6a,13-diaza-indeno[2,1-a]anthracene-11-carboxylic acid methyl ester::AKUAMMIGINE::CHEMBL122404 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1210 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030622&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 1268096 103939471 CHEMBL122404 ZINC53174616 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162036 COc1ccccc1N1CCN(CCC2C(=O)c3ccccc3C(C)(C)C2=O)CC1 InChI=1S/C25H30N2O3/c1-25(2)20-9-5-4-8-18(20)23(28)19(24(25)29)12-13-26-14-16-27(17-15-26)21-10-6-7-11-22(21)30-3/h4-11,19H,12-17H2,1-3H3 OSEADGVOKYGIER-UHFFFAOYSA-N 81772 ARC-239::CAS_122211::NSC_122211 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 749 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81772&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 122211 131342346 524 ZINC60027297 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162038 CN1C[C@H](Cn2ccnc2-c2ccccc2)C[C@H]2[C@H]1Cc1c(Br)[nH]c3cccc2c13 InChI=1S/C25H25BrN4/c1-29-14-16(15-30-11-10-27-25(30)17-6-3-2-4-7-17)12-19-18-8-5-9-21-23(18)20(13-22(19)29)24(26)28-21/h2-11,16,19,22,28H,12-15H2,1H3/t16-,19-,22-/m1/s1 VKABNRMTNPWHBD-ZWDAVXSWSA-N 81773 BAM 1303::BAM-1303::CAS_115219-10-8 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 35 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81773&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10344262 131342347 ZINC38563583 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162040 CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12 InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 50001888 (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine::(chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine::1-(2-Allyl-phenoxy)-3-isopropylamino-propan-2-ol::1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine::3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine::CHEMBL71::CHLORPROMAZINE::CHLORPROMAZINE HIBENZATE::CHLORPROMAZINE HYDROCHLORIDE::CHLORPROMAZINE PHENOLPHTHALINATE::CHLORPROMAZINE TANNATE::Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine::PROMAPAR::SONAZINE::THORAZINE::[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine)::[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine)::[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine)::chloropromazine::med.21724, Compound 15 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 388 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001888&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search Z80 3LK0,5NUM,5NUN,5NUJ,5NUK,5G08,4MA8,7OOK,5LG3,3APX 2726 103916255 3647 CHEMBL71 DB00477 83 C06906 ZINC00044027 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162042 NCC(O)c1ccc(O)c(O)c1 InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 SFLSHLFXELFNJZ-UHFFFAOYSA-N 35234 DL-[7-3H]norepinephrine::NOREPINEPHRINE::Noradrenaline,(+)::[3H]NE Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 3190 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35234&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search LNR 3HCD,4Y4J,6M2R,3DYE,6M0Z,2QEO,4PAH 951 85753313 33569 484 ZINC00057624 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162044 Cc1cc(c(O)c(C)c1CC1=NCCN1)C(C)(C)C InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18) WYWIFABBXFUGLM-UHFFFAOYSA-N 30712 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-phenol;hydrochloride::6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-phenol;hydrochloride::6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol;hydrochloride::MLS000038040::Oxymetazoline::SMR000059324::cid_66259 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 17 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30712&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search J5C 7EJK 4636 252614969 DB00935 C07363 ZINC00057435 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162046 Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1 InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19) MRBDMNSDAVCSSF-UHFFFAOYSA-N 31046 3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol;methanesulfonic acid::3-[N-(2-imidazolin-2-ylmethyl)-4-methyl-anilino]phenol;hydrochloride::3-[N-(2-imidazolin-2-ylmethyl)-4-methyl-anilino]phenol;mesylic acid::3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;methanesulfonic acid::MLS000069487::PHENTOLAMINE::PHENTOLAMINE MESYLATE::SMR000059054::cid_5775::cid_91430 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 4.9 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31046&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5775 252615298 DB00692 ZINC00020251 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162048 COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) IENZQIKPVFGBNW-UHFFFAOYSA-N 29568 CHEMBL2::PRAZOSIN::PRAZOSIN HYDROCHLORIDE::[3H]-Furazosin::[3H]-Minipress::[3H]-Pratsiol::[3H]-Prazosin Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 890 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29568&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search XRA 3OWX 4893 81054997 8364 CHEMBL2 DB00457 503 C07368 ZINC00601304 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162050 COC(=O)C1=COC(C)C2CN3CCc4c([nH]c5ccccc45)C3CC12 InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3 GRTOGORTSDXSFK-UHFFFAOYSA-N 30993 Ajmalicine::MLS000111555::Raubasine::SMR000107477::cid_251561 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 289 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30993&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search AJN 4WNT 251561 242052838 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162052 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 50013515 (+)-yohimbine::(16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester::17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester::CHEMBL15245::CORYNANTHINE::Johimbin::Quebrachin::RAUWOLSCINE::YOHIMBINE CHLORIDE::Yohimbin::Yohimbine::aphrodine::cid_8969::corynine::methyl 17alpha-hydroxyyohimban-16alpha-carboxylate::quebrachine::yohimbic acid methyl ester Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 19 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013515&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 8969 103925641 48565 CHEMBL15245 DB01392 102 C09256 ZINC03860825 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162054 CN1CCc2c(Cl)ccc(OCC=C(C)C)c2CC1 InChI=1S/C16H22ClNO/c1-12(2)8-11-19-16-5-4-15(17)13-6-9-18(3)10-7-14(13)16/h4-5,8H,6-7,9-11H2,1-3H3 MBYSTKNEMJZSIK-UHFFFAOYSA-N 50030623 6-Chloro-3-methyl-9-(3-methyl-but-2-enyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine::CHEMBL114166::SK&F-104078::SK-104078::SKF 104078 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 248 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030623&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 122295 103939472 CHEMBL114166 ZINC05158824 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162056 O=C1NCN(c2ccccc2)C11CCN(CC2COc3ccccc3O2)CC1 InChI=1S/C22H25N3O3/c26-21-22(25(16-23-21)17-6-2-1-3-7-17)10-12-24(13-11-22)14-18-15-27-19-8-4-5-9-20(19)28-18/h1-9,18H,10-16H2,(H,23,26) JVGBTTIJPBFLTE-UHFFFAOYSA-N 50020192 8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL300555::Spiroxatrine Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 70 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50020192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50020192&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5268 103931109 CHEMBL300555 53 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 162058 COc1cccc(OC)c1OCCNCC1Oc2ccccc2OC1c1ccccc1 InChI=1S/C25H27NO5/c1-27-21-13-8-14-22(28-2)25(21)29-16-15-26-17-23-24(18-9-4-3-5-10-18)31-20-12-7-6-11-19(20)30-23/h3-14,23-24,26H,15-17H2,1-2H3 UVEKKXRFQCNLQE-UHFFFAOYSA-N 81444 CAS_185453::NSC_185453::WB 4101::WB-4101 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 46 PDSP Ki 10.7270/Q2VD6X0Z 7965790 O'Rourke, MF; Iversen, LJ; Lomasney, JW; Bylund, DB University of Nebraska http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81444&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 14743454 131342018 ZINC14953628 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 171394 CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1 InChI=1S/C19H29ClN2O2/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2/h12-14H,3-11,21H2,1-2H3 JBHLYIVFFLNISJ-UHFFFAOYSA-N 84950 CAS_183782::NSC_183782::RS 67333 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 PDSP Ki 10.1111/j.1476-5381.1995.tb16628.x 10.7270/Q23B5XP1 8564196 Eglen, RM; Bonhaus, DW; Johnson, LG; Leung, E; Clark, RD Syntex Discovery Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84950&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 183782 136351050 237 ZINC01541803 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 171395 COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(CCNS(C)(=O)=O)CC1 InChI=1S/C18H28ClN3O4S/c1-26-18-12-16(20)15(19)11-14(18)17(23)4-3-13-5-8-22(9-6-13)10-7-21-27(2,24)25/h11-13,21H,3-10,20H2,1-2H3 UATDVRSFFGFTAI-UHFFFAOYSA-N 84951 CAS_133075::NSC_133075::RS 67506 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 PDSP Ki 10.1111/j.1476-5381.1995.tb16628.x 10.7270/Q23B5XP1 8564196 Eglen, RM; Bonhaus, DW; Johnson, LG; Leung, E; Clark, RD Syntex Discovery Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84951&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 133076 136351051 ZINC00600432 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 180032 Fc1cccc2OC3CNCC3Oc12 InChI=1S/C10H10FNO2/c11-6-2-1-3-7-10(6)14-9-5-12-4-8(9)13-7/h1-3,8-9,12H,4-5H2 XSOUHEXVEOQRKJ-UHFFFAOYSA-N 85595 CAS_105182-45-4::Fluparoxan::NSC_72036 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1.25 PDSP Ki 10.1002/(SICI)1098-2396(200002)35:2<79::AID-SYN1>3.0.CO;2-X 10.7270/Q2XK8D4N 10611634 Millan, MJ; Newman-Tancredi, A; Audinot, V; Cussac, D; Lejeune, F; Nicolas, JP; Coge, F; Galizzi, JP; Boutin, JA; Rivet, JM; Dekeyne, A; Gobert, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85595&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10219795 136351695 41 ZINC11680328 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 180035 Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1 InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19) MRBDMNSDAVCSSF-UHFFFAOYSA-N 31046 3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol;methanesulfonic acid::3-[N-(2-imidazolin-2-ylmethyl)-4-methyl-anilino]phenol;hydrochloride::3-[N-(2-imidazolin-2-ylmethyl)-4-methyl-anilino]phenol;mesylic acid::3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;methanesulfonic acid::MLS000069487::PHENTOLAMINE::PHENTOLAMINE MESYLATE::SMR000059054::cid_5775::cid_91430 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 6.3 PDSP Ki 10.1002/(SICI)1098-2396(200002)35:2<79::AID-SYN1>3.0.CO;2-X 10.7270/Q2XK8D4N 10611634 Millan, MJ; Newman-Tancredi, A; Audinot, V; Cussac, D; Lejeune, F; Nicolas, JP; Coge, F; Galizzi, JP; Boutin, JA; Rivet, JM; Dekeyne, A; Gobert, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31046&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5775 252615298 DB00692 ZINC00020251 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 180040 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 50013515 (+)-yohimbine::(16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester::17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester::CHEMBL15245::CORYNANTHINE::Johimbin::Quebrachin::RAUWOLSCINE::YOHIMBINE CHLORIDE::Yohimbin::Yohimbine::aphrodine::cid_8969::corynine::methyl 17alpha-hydroxyyohimban-16alpha-carboxylate::quebrachine::yohimbic acid methyl ester Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 63.09 PDSP Ki 10.1002/(SICI)1098-2396(200002)35:2<79::AID-SYN1>3.0.CO;2-X 10.7270/Q2XK8D4N 10611634 Millan, MJ; Newman-Tancredi, A; Audinot, V; Cussac, D; Lejeune, F; Nicolas, JP; Coge, F; Galizzi, JP; Boutin, JA; Rivet, JM; Dekeyne, A; Gobert, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013515&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 8969 103925641 48565 CHEMBL15245 DB01392 102 C09256 ZINC03860825 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182539 CCC(=O)Nc1c(C)cc(cc1C)C(=O)N1CCC(CC1)N(C)CCc1ccccc1 InChI=1S/C26H35N3O2/c1-5-24(30)27-25-19(2)17-22(18-20(25)3)26(31)29-15-12-23(13-16-29)28(4)14-11-21-9-7-6-8-10-21/h6-10,17-18,23H,5,11-16H2,1-4H3,(H,27,30) BESKMDLUOAVUJF-UHFFFAOYSA-N 85825 CAS_219019::NSC_219019::OPC-28326 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 3840 PDSP Ki 10.7270/Q2TB15FS 11602678 Sun, B; Lockyer, S; Li, J; Chen, R; Yoshitake, M; Kambayashi, JI Otsuka Maryland Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85825&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 219020 136351925 DB05461 ZINC03985553 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182540 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 50013515 (+)-yohimbine::(16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester::17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester::CHEMBL15245::CORYNANTHINE::Johimbin::Quebrachin::RAUWOLSCINE::YOHIMBINE CHLORIDE::Yohimbin::Yohimbine::aphrodine::cid_8969::corynine::methyl 17alpha-hydroxyyohimban-16alpha-carboxylate::quebrachine::yohimbic acid methyl ester Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 59 PDSP Ki 10.7270/Q2TB15FS 11602678 Sun, B; Lockyer, S; Li, J; Chen, R; Yoshitake, M; Kambayashi, JI Otsuka Maryland Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013515&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 8969 103925641 48565 CHEMBL15245 DB01392 102 C09256 ZINC03860825 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 181294 Clc1cccc(Cl)c1N=C1NCCN1 InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) GJSURZIOUXUGAL-UHFFFAOYSA-N 50016897 2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2)::2-(2,6-dichloroanilino)-2-imidazoline::CLONIDINE::N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine::clonidine (amino form) Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 25.1189 PDSP Ki 10.7270/Q28P5Z2C 11082457 Millan, MJ; Dekeyne, A; Newman-Tancredi, A; Cussac, D; Audinot, V; Milligan, G; Duqueyroix, D; Girardon, S; Mullot, J; Boutin, JA; Nicolas, JP; Renouard-Try, A; Lacoste, JM; Cordi, A Centre de Recherches de Croissy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016897&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search CLU 2PNC,7AWW 2803 103928231 46632 516 ZINC00896484 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 181302 NC1=NC2(CO1)CCc1ccccc1C2 InChI=1S/C12H14N2O/c13-11-14-12(8-15-11)6-5-9-3-1-2-4-10(9)7-12/h1-4H,5-8H2,(H2,13,14) ZFZUYTCCHMWWTD-UHFFFAOYSA-N 85709 S18616 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.2512 PDSP Ki 10.7270/Q28P5Z2C 11082457 Millan, MJ; Dekeyne, A; Newman-Tancredi, A; Cussac, D; Audinot, V; Milligan, G; Duqueyroix, D; Girardon, S; Mullot, J; Boutin, JA; Nicolas, JP; Renouard-Try, A; Lacoste, JM; Cordi, A Centre de Recherches de Croissy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85709&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10442840 136351809 ZINC13743776 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 180862 CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1 InChI=1S/C24H33NO3S/c1-4-14-25(15-5-2)22-9-8-20-16-19(6-7-21(20)17-22)18-29(26,27)24-12-10-23(28-3)11-13-24/h6-7,10-13,16,22H,4-5,8-9,14-15,17-18H2,1-3H3 HUXFXXWYIRBVJR-UHFFFAOYSA-N 50240797 6-((4-methoxyphenylsulfonyl)methyl)-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine::CHEMBL334529::GR-218231::GR218231::[6-(4-Methoxy-benzenesulfonylmethyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-dipropyl-amine Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 398.11 PDSP Ki 10.7270/Q2ZC81DX 10869410 Millan, MJ; Gobert, A; Newman-Tancredi, A; Lejeune, F; Cussac, D; Rivet, JM; Audinot, V; Dubuffet, T; Lavielle, G Centre de Recherches de Croissy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240797&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 24840389 104098462 CHEMBL334529 ZINC06013412 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 180863 OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)cc1 InChI=1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2 LLBLNMUONVVVPG-UHFFFAOYSA-N 50050467 1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperidin-4-ol::3-[4-(4-chlorophenyl)-4-hydroxypiperidinyl]methylindole::4-(4-Chloro-phenyl)-1-(1H-indol-3-ylmethyl)-piperidin-4-ol::CHEMBL445102::L-741626::L741,626 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1258.93 PDSP Ki 10.7270/Q2ZC81DX 10869410 Millan, MJ; Gobert, A; Newman-Tancredi, A; Lejeune, F; Cussac, D; Rivet, JM; Audinot, V; Dubuffet, T; Lavielle, G Centre de Recherches de Croissy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50050467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50050467&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 133633 103947637 CHEMBL445102 177 ZINC00006788 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 180864 O=C(NCCCCN1C[C@@H]2COc3ccc(cc3[C@H]2C1)C#N)c1ccc(cc1)-c1ccccc1 InChI=1S/C29H29N3O2/c30-17-21-8-13-28-26(16-21)27-19-32(18-25(27)20-34-28)15-5-4-14-31-29(33)24-11-9-23(10-12-24)22-6-2-1-3-7-22/h1-3,6-13,16,25,27H,4-5,14-15,18-20H2,(H,31,33)/t25-,27+/m1/s1 QQJHRQZZCNYDMX-VPUSJEBWSA-N 85672 S33084 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1000 PDSP Ki 10.7270/Q2ZC81DX 10869410 Millan, MJ; Gobert, A; Newman-Tancredi, A; Lejeune, F; Cussac, D; Rivet, JM; Audinot, V; Dubuffet, T; Lavielle, G Centre de Recherches de Croissy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85672&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9868452 136351772 ZINC03941217 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182078 COc1ccccc1N1CCN(CCC2C(=O)c3ccccc3C(C)(C)C2=O)CC1 InChI=1S/C25H30N2O3/c1-25(2)20-9-5-4-8-18(20)23(28)19(24(25)29)12-13-26-14-16-27(17-15-26)21-10-6-7-11-22(21)30-3/h4-11,19H,12-17H2,1-3H3 OSEADGVOKYGIER-UHFFFAOYSA-N 81772 ARC-239::CAS_122211::NSC_122211 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 484 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81772&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 122211 131342346 524 ZINC60027297 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182079 CN1C[C@H](Cn2ccnc2-c2ccccc2)C[C@H]2[C@H]1Cc1c(Br)[nH]c3cccc2c13 InChI=1S/C25H25BrN4/c1-29-14-16(15-30-11-10-27-25(30)17-6-3-2-4-7-17)12-19-18-8-5-9-21-23(18)20(13-22(19)29)24(26)28-21/h2-11,16,19,22,28H,12-15H2,1H3/t16-,19-,22-/m1/s1 VKABNRMTNPWHBD-ZWDAVXSWSA-N 81773 BAM 1303::BAM-1303::CAS_115219-10-8 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 313 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81773&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10344262 131342347 ZINC38563583 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182080 CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12 InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 50001888 (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine::(chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine::1-(2-Allyl-phenoxy)-3-isopropylamino-propan-2-ol::1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine::3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine::CHEMBL71::CHLORPROMAZINE::CHLORPROMAZINE HIBENZATE::CHLORPROMAZINE HYDROCHLORIDE::CHLORPROMAZINE PHENOLPHTHALINATE::CHLORPROMAZINE TANNATE::Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine::PROMAPAR::SONAZINE::THORAZINE::[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine)::[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine)::[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine)::chloropromazine::med.21724, Compound 15 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 913 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001888&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search Z80 3LK0,5NUM,5NUN,5NUJ,5NUK,5G08,4MA8,7OOK,5LG3,3APX 2726 103916255 3647 CHEMBL71 DB00477 83 C06906 ZINC00044027 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182081 NCC(O)c1ccc(O)c(O)c1 InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 SFLSHLFXELFNJZ-UHFFFAOYSA-N 35234 DL-[7-3H]norepinephrine::NOREPINEPHRINE::Noradrenaline,(+)::[3H]NE Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1031 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35234&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search LNR 3HCD,4Y4J,6M2R,3DYE,6M0Z,2QEO,4PAH 951 85753313 33569 484 ZINC00057624 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182082 Cc1cc(c(O)c(C)c1CC1=NCCN1)C(C)(C)C InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18) WYWIFABBXFUGLM-UHFFFAOYSA-N 30712 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-phenol;hydrochloride::6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-phenol;hydrochloride::6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol;hydrochloride::MLS000038040::Oxymetazoline::SMR000059324::cid_66259 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 37 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30712&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search J5C 7EJK 4636 252614969 DB00935 C07363 ZINC00057435 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182083 Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1 InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19) MRBDMNSDAVCSSF-UHFFFAOYSA-N 31046 3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol;methanesulfonic acid::3-[N-(2-imidazolin-2-ylmethyl)-4-methyl-anilino]phenol;hydrochloride::3-[N-(2-imidazolin-2-ylmethyl)-4-methyl-anilino]phenol;mesylic acid::3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;methanesulfonic acid::MLS000069487::PHENTOLAMINE::PHENTOLAMINE MESYLATE::SMR000059054::cid_5775::cid_91430 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 3.7 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31046&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5775 252615298 DB00692 ZINC00020251 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182084 COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) IENZQIKPVFGBNW-UHFFFAOYSA-N 29568 CHEMBL2::PRAZOSIN::PRAZOSIN HYDROCHLORIDE::[3H]-Furazosin::[3H]-Minipress::[3H]-Pratsiol::[3H]-Prazosin Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 722 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29568&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search XRA 3OWX 4893 81054997 8364 CHEMBL2 DB00457 503 C07368 ZINC00601304 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182085 COC(=O)C1=COC(C)C2CN3CCc4c([nH]c5ccccc45)C3CC12 InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3 GRTOGORTSDXSFK-UHFFFAOYSA-N 30993 Ajmalicine::MLS000111555::Raubasine::SMR000107477::cid_251561 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1472 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30993&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search AJN 4WNT 251561 242052838 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182086 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 50013515 (+)-yohimbine::(16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester::17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester::CHEMBL15245::CORYNANTHINE::Johimbin::Quebrachin::RAUWOLSCINE::YOHIMBINE CHLORIDE::Yohimbin::Yohimbine::aphrodine::cid_8969::corynine::methyl 17alpha-hydroxyyohimban-16alpha-carboxylate::quebrachine::yohimbic acid methyl ester Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 63.6 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013515&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 8969 103925641 48565 CHEMBL15245 DB01392 102 C09256 ZINC03860825 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182087 COC1(COc2ccccc2O1)C1=NCCN1 InChI=1S/C12H14N2O3/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12/h2-5H,6-8H2,1H3,(H,13,14) HQGWKNGAKBPTBX-UHFFFAOYSA-N 50019492 (+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole::(-)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole::2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole::2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole::2-(2-methoxy-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole::2-ethoxy-idazoxan::CHEMBL10332::RX-821002::RX821002 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.95 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019492&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 108094 103930440 73287 CHEMBL10332 528 ZINC03995905 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182088 CN1CCc2c(Cl)ccc(OCC=C(C)C)c2CC1 InChI=1S/C16H22ClNO/c1-12(2)8-11-19-16-5-4-15(17)13-6-9-18(3)10-7-14(13)16/h4-5,8H,6-7,9-11H2,1-3H3 MBYSTKNEMJZSIK-UHFFFAOYSA-N 50030623 6-Chloro-3-methyl-9-(3-methyl-but-2-enyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine::CHEMBL114166::SK&F-104078::SK-104078::SKF 104078 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 244 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030623&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 122295 103939472 CHEMBL114166 ZINC05158824 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182089 O=C1NCN(c2ccccc2)C11CCN(CC2COc3ccccc3O2)CC1 InChI=1S/C22H25N3O3/c26-21-22(25(16-23-21)17-6-2-1-3-7-17)10-12-24(13-11-22)14-18-15-27-19-8-4-5-9-20(19)28-18/h1-9,18H,10-16H2,(H,23,26) JVGBTTIJPBFLTE-UHFFFAOYSA-N 50020192 8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL300555::Spiroxatrine Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 92 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50020192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50020192&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5268 103931109 CHEMBL300555 53 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182090 COc1cccc(OC)c1OCCNCC1Oc2ccccc2OC1c1ccccc1 InChI=1S/C25H27NO5/c1-27-21-13-8-14-22(28-2)25(21)29-16-15-26-17-23-24(18-9-4-3-5-10-18)31-20-12-7-6-11-19(20)30-23/h3-14,23-24,26H,15-17H2,1-2H3 UVEKKXRFQCNLQE-UHFFFAOYSA-N 81444 CAS_185453::NSC_185453::WB 4101::WB-4101 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 142 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81444&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 14743454 131342018 ZINC14953628 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 182091 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 50013515 (+)-yohimbine::(16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester::17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester::CHEMBL15245::CORYNANTHINE::Johimbin::Quebrachin::RAUWOLSCINE::YOHIMBINE CHLORIDE::Yohimbin::Yohimbine::aphrodine::cid_8969::corynine::methyl 17alpha-hydroxyyohimban-16alpha-carboxylate::quebrachine::yohimbic acid methyl ester Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 66 PDSP Ki 10.7270/Q2MS3R9D 11408545 Naselsky, DP; Ashton, D; Ruffolo, RR; Hieble, JP GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013515&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 8969 103925641 48565 CHEMBL15245 DB01392 102 C09256 ZINC03860825 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184560 CN1CCc2cccc-3c2[C@H]1Cc1ccc(O)c(O)c-31 InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m1/s1 VMWNQDUVQKEIOC-CYBMUJFWSA-N 50001955 (-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol(APO)::(Apomorphine) 6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::(R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol ((R)-apomorphine)::(R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol (apomorphine)::(R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol(apomorphine)::(apomorphine)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol ((R)-apomorphine)::6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol((R)-apomorphine)::APOKYN::APOMORPHINE::APOMORPHINE HYDROCHLORIDE::APOMORPHINE6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol::CHEMBL53 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 323.59 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001955&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search OR9 7JVQ 6005 103916308 48538 CHEMBL53 DB00714 33 ZINC00009073 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184561 CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@H]3CN(C)[C@@H]4Cc5c(Br)[nH]c6cccc(C4=C3)c56)(O[C@@]2(O)[C@@H]2CCCN2C1=O)C(C)C InChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1 OZVBMTJYIDMWIL-AYFBDAFISA-N 81993 BROMOCRIPTINE::Bromocriptine+ (GTP+)::Bromocriptine+ (GTP-) Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 67.61 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81993&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 08Y 6VMS,3UA1,7JVR,5VCG 31101 131342567 DB01200 C06856 ZINC53683151 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184562 CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(Cc3c[nH]c4cccc2c34)N(CC=C)C1 InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33) KORNTPPJEAJQIU-UHFFFAOYSA-N 86052 CAS_54746::Cabergoline::NSC_54746 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 3.63 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86052&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 2512 136352152 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184563 CCN(CC)C(=O)N[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18-/m1/s1 BKRGVLQUQGGVSM-RDTXWAMCSA-N 22867 1,1-diethyl-3-[(8beta)-6-methyl-9,10-didehydroergolin-8-yl]urea::3,3-diethyl-1-[(4R,7R)-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(15),2,9,12(16),13-pentaen-4-yl]urea::8R-lisuride::LISURIDE Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.79 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22867&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 11957615 49846681 ZINC03831002 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184564 C(N1CCN(CC1)c1ncccn1)c1ccc2OCOc2c1 InChI=1S/C16H18N4O2/c1-4-17-16(18-5-1)20-8-6-19(7-9-20)11-13-2-3-14-15(10-13)22-12-21-14/h1-5,10H,6-9,11-12H2 OQDPVLVUJFGPGQ-UHFFFAOYSA-N 85092 CAS_3605-01-4::NSC_4850::Piribedil Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 436.52 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85092&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 4850 136351192 ZINC19537374 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184565 CCCNC1CCc2nc(N)sc2C1 InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13) FASDKYOPVNHBLU-UHFFFAOYSA-N 50017550 CHEMBL76399::N*6*-Propyl-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine::N*6*-Propyl-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine (Pramipexole, PPX)::Pramipexole Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 5495.41 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017550&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search G6L 7CMU 4885 103928818 CHEMBL76399 ZINC03831352 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184566 CCCN1CCC[C@@H]2Cc3nc(N)ncc3C[C@@H]12 InChI=1S/C14H22N4/c1-2-5-18-6-3-4-10-7-12-11(8-13(10)18)9-16-14(15)17-12/h9-10,13H,2-8H2,1H3,(H2,15,16,17)/t10-,13-/m1/s1 TUFADSGTJUOBEH-ZWNOBZJWSA-N 50016017 (5aR,9aR)-6-Propyl-5,5a,6,7,8,9,9a,10-octahydro-pyrido[2,3-g]quinazolin-2-ylamine::(5aR,9aR)-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido[2,3-g]quinazolin-2-amine::6-Propyl-5,5a,6,7,8,9,9a,10-octahydro-pyrido[2,3-g]quinazolin-2-ylamine(Quinelorane)::CHEMBL155731::Quinelorane::Quinerolane Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016017&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 57242 103927698 CHEMBL155731 954 ZINC00005041 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184567 CCCN1CCC[C@@H]2Cc3[nH]ncc3C[C@@H]12 InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1 FTSUPYGMFAPCFZ-ZWNOBZJWSA-N 84637 CAS_85760-74-3::CHEMBL240773::NSC_54562::QUINPIROLE::Quinpirole,(-)::US9359372, Quinpirole Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84637&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 54562 136350737 CHEMBL240773 ZINC25724686 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184568 CCCN(CCC)CCc1cccc2NC(=O)Cc12 InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19) UHSKFQJFRQCDBE-UHFFFAOYSA-N 50020680 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one::CHEMBL589::ROPINIROLE Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 4466.84 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50020680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50020680&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5095 103931441 8888 CHEMBL589 DB00268 7295 C07564 ZINC00002041 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184569 Oc1ccc2[nH]cc(CCCCN3CCC(=CC3)c3ccccc3)c2c1 InChI=1S/C23H26N2O/c26-21-9-10-23-22(16-21)20(17-24-23)8-4-5-13-25-14-11-19(12-15-25)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,24,26H,4-5,8,12-15H2 HGEYJZMMUGWEOT-UHFFFAOYSA-N 50002173 3-(4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl)-1H-indol-5-ol::3-[4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)butyl]-1H-indol-5-ol::3-[4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)butyl]-1H-indol-5-ol::CHEMBL431367::roxindole Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 27.54 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50002173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50002173&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 219050 103916479 48558 CHEMBL431367 52 ZINC01548439 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184570 Nc1nc2CCN(CC=C)CCc2s1 InChI=1S/C10H15N3S/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8/h2H,1,3-7H2,(H2,11,12) DHSSDEDRBUKTQY-UHFFFAOYSA-N 86053 B-HT 920::CAS_101626-70-4::CHEMBL279085::NSC_104870::Talipexole::cid_5374 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 162.18 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86053&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5374 136352153 CHEMBL279085 ZINC00006644 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184571 CCN(CC)C(=O)N[C@H]1C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(C)C1 InChI=1S/C20H28N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,11,14,16,18,21H,4-5,9-10,12H2,1-3H3,(H,22,25)/t14-,16+,18+/m0/s1 JOAHPSVPXZTVEP-YXJHDRRASA-N 50017519 1,1-Diethyl-3-(7-methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-9-yl)-urea::CHEMBL73151::Terguride Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1.48 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017519&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 443951 103928787 CHEMBL73151 ZINC03811327 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 184572 C[NH+](C)C1CCc2cc(O)c(O)cc2C1 InChI=1S/C12H17NO2/c1-13(2)10-4-3-8-6-11(14)12(15)7-9(8)5-10/h6-7,10,14-15H,3-5H2,1-2H3/p+1 JWLJBTDXCBIGBW-UHFFFAOYSA-O 50025206 (6,7-Dihydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dimethyl-ammonium::TL99 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 46.77 PDSP Ki 10.1124/jpet.102.039867 10.7270/Q2MG7N2F 12388666 Millan, MJ; Maiofiss, L; Cussac, D; Audinot, V; Boutin, JA; Newman-Tancredi, A Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50025206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50025206&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 44299913 103935110 ZINC05965207 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 188833 CC(C)C(=O)N(C1CC(C)N(C(=O)c2ccccc2)c2ccccc12)c1ccccc1 InChI=1S/C27H28N2O2/c1-19(2)26(30)29(22-14-8-5-9-15-22)25-18-20(3)28(24-17-11-10-16-23(24)25)27(31)21-12-6-4-7-13-21/h4-17,19-20,25H,18H2,1-3H3 FTCWKSGDHXCEMZ-UHFFFAOYSA-N 86692 K117 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 PDSP Ki 10.1124/jpet.104.081539 10.7270/Q2RN36FF 15798001 Mimura, H; Ikemura, T; Kotera, O; Sawada, M; Tashiro, S; Fuse, E; Ueno, K; Manabe, H; Ohshima, E; Karasawa, A; Miyaji, H Kyowa Hakko Kogyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86692&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 3723424 136352741 ZINC13897246 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 188834 CCC(=O)N1C(C)CC(N(C(C)=O)c2ccccc2)c2ccccc12 InChI=1S/C21H24N2O2/c1-4-21(25)22-15(2)14-20(18-12-8-9-13-19(18)22)23(16(3)24)17-10-6-5-7-11-17/h5-13,15,20H,4,14H2,1-3H3 DRQJSDYVORTCEY-UHFFFAOYSA-N 86693 K376 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 PDSP Ki 10.1124/jpet.104.081539 10.7270/Q2RN36FF 15798001 Mimura, H; Ikemura, T; Kotera, O; Sawada, M; Tashiro, S; Fuse, E; Ueno, K; Manabe, H; Ohshima, E; Karasawa, A; Miyaji, H Kyowa Hakko Kogyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86693&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 4271604 136352742 ZINC00031401 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 188835 CC1CC(N(C(=O)C2CC2)c2ccccc2)c2ccccc2N1C(=O)c1ccccc1 InChI=1S/C27H26N2O2/c1-19-18-25(29(27(31)21-16-17-21)22-12-6-3-7-13-22)23-14-8-9-15-24(23)28(19)26(30)20-10-4-2-5-11-20/h2-15,19,21,25H,16-18H2,1H3 VGFZCFWVSYIXEK-UHFFFAOYSA-N 86691 K604 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 PDSP Ki 10.1124/jpet.104.081539 10.7270/Q2RN36FF 15798001 Mimura, H; Ikemura, T; Kotera, O; Sawada, M; Tashiro, S; Fuse, E; Ueno, K; Manabe, H; Ohshima, E; Karasawa, A; Miyaji, H Kyowa Hakko Kogyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86691&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 57340709 136352740 ZINC27098753 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 187659 CCCN(CCC)CCc1cccc2NC(=O)Cc12 InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19) UHSKFQJFRQCDBE-UHFFFAOYSA-N 50020680 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one::CHEMBL589::ROPINIROLE Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 4466.84 PDSP Ki 10.1124/jpet.103.062398 10.7270/Q29S1PM2 14978194 Millan, MJ; Cussac, D; Gobert, A; Lejeune, F; Rivet, JM; Mannoury La Cour, C; Newman-Tancredi, A; Peglion, JL Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50020680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50020680&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5095 103931441 8888 CHEMBL589 DB00268 7295 C07564 ZINC00002041 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 187660 CCCN1CCOC2C1CCc1ccc(cc21)C(N)=O InChI=1S/C16H22N2O2/c1-2-7-18-8-9-20-15-13-10-12(16(17)19)4-3-11(13)5-6-14(15)18/h3-4,10,14-15H,2,5-9H2,1H3,(H2,17,19) XKTRZPQOQOCNJU-UHFFFAOYSA-N 86475 S32504 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 PDSP Ki 10.1124/jpet.103.062398 10.7270/Q29S1PM2 14978194 Millan, MJ; Cussac, D; Gobert, A; Lejeune, F; Rivet, JM; Mannoury La Cour, C; Newman-Tancredi, A; Peglion, JL Institut de Recherches Servier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86475&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9925530 136352524 ZINC34031100 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50050104 COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) IENZQIKPVFGBNW-UHFFFAOYSA-N 29568 CHEMBL2::PRAZOSIN::PRAZOSIN HYDROCHLORIDE::[3H]-Furazosin::[3H]-Minipress::[3H]-Pratsiol::[3H]-Prazosin Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1668 ChEMBL 10.1021/jm00018a001 10.7270/Q20G3J6W 7658428 Hieble, JP; Bondinell, WE; Ruffolo, RR SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29568&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search XRA 3OWX 4893 81054997 8364 CHEMBL2 DB00457 503 C07368 ZINC00601304 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50050141 Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1 InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19) MRBDMNSDAVCSSF-UHFFFAOYSA-N 31046 3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol;methanesulfonic acid::3-[N-(2-imidazolin-2-ylmethyl)-4-methyl-anilino]phenol;hydrochloride::3-[N-(2-imidazolin-2-ylmethyl)-4-methyl-anilino]phenol;mesylic acid::3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;methanesulfonic acid::MLS000069487::PHENTOLAMINE::PHENTOLAMINE MESYLATE::SMR000059054::cid_5775::cid_91430 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 4.7 ChEMBL 10.1021/jm00018a001 10.7270/Q20G3J6W 7658428 Hieble, JP; Bondinell, WE; Ruffolo, RR SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31046&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5775 252615298 DB00692 ZINC00020251 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50050178 COc1cccc(OC)c1OCCNCC1COc2ccccc2O1 InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3 GYSZUJHYXCZAKI-UHFFFAOYSA-N 69602 2,3-dihydro-1,4-benzodioxin-3-ylmethyl-[2-(2,6-dimethoxyphenoxy)ethyl]amine;hydrochloride::CHEMBL25554::MLS000859914::N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine;hydrochloride::SMR000326775::WB-4101::WB-4101 hydrochloride::cid_11957505 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 46 ChEMBL 10.1021/jm00018a001 10.7270/Q20G3J6W 7658428 Hieble, JP; Bondinell, WE; Ruffolo, RR SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=69602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=69602&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5685 252647768 64094 CHEMBL25554 ZINC02169424 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50050214 CN1CCc2c(Cl)ccc(OCC=C(C)C)c2CC1 InChI=1S/C16H22ClNO/c1-12(2)8-11-19-16-5-4-15(17)13-6-9-18(3)10-7-14(13)16/h4-5,8H,6-7,9-11H2,1-3H3 MBYSTKNEMJZSIK-UHFFFAOYSA-N 50030623 6-Chloro-3-methyl-9-(3-methyl-but-2-enyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine::CHEMBL114166::SK&F-104078::SK-104078::SKF 104078 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 313 ChEMBL 10.1021/jm00018a001 10.7270/Q20G3J6W 7658428 Hieble, JP; Bondinell, WE; Ruffolo, RR SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030623&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 122295 103939472 CHEMBL114166 ZINC05158824 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50068040 Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3 FELGMEQIXOGIFQ-UHFFFAOYSA-N 85330 CAS_68647::NSC_68647::ONDANSETRON::Ondansetron hydrochloride Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 ChEMBL 10.1021/jm00075a026 10.7270/Q2NS0SZH 8246239 van Wijngaarden, I; Hamminga, D; van Hes, R; Standaar, PJ; Tipker, J; Tulp, MT; Mol, F; Olivier, B; de Jonge, A Solvay Duphar B.V. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85330&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search S87 6W1M 4595 136351430 DB00904 C07325 ZINC00075126 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50097716 Cc1cccc(c1)C(=O)NCN1CCN(CC1)c1ccccc1C#N InChI=1S/C20H22N4O/c1-16-5-4-7-17(13-16)20(25)22-15-23-9-11-24(12-10-23)19-8-3-2-6-18(19)14-21/h2-8,13H,9-12,15H2,1H3,(H,22,25) DNULYRGWTFLJQL-UHFFFAOYSA-N 50058225 CHEMBL45244::N-((4-(2-cyanophenyl)piperazin-1-yl)methyl)-3-methylbenzamide::N-[4-(2-Cyano-phenyl)-piperazin-1-ylmethyl]-3-methyl-benzamide::PD-168077 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 168 ChEMBL 10.1021/jm970021c 10.7270/Q2DB80XX 9191952 Glase, SA; Akunne, HC; Georgic, LM; Heffner, TG; MacKenzie, RG; Manley, PJ; Pugsley, TA; Wise, LD Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50058225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50058225&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 3645619 103954202 CHEMBL45244 975 ZINC25758996 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50121736 Cc1ccc(cc1C)N1CCN(CC[C@H]2NC(=O)c3ccccc23)CC1 InChI=1S/C22H27N3O/c1-16-7-8-18(15-17(16)2)25-13-11-24(12-14-25)10-9-21-19-5-3-4-6-20(19)22(26)23-21/h3-8,15,21H,9-14H2,1-2H3,(H,23,26)/t21-/m1/s1 WQEPZBNLBWDIRZ-OAQYLSRUSA-N 50070518 (R)-3-{2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-yl]-ethyl}-2,3-dihydro-isoindol-1-one::CHEMBL35093::PD-172939 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 127 ChEMBL 10.1016/s0960-894x(98)00252-2 10.7270/Q2WH2P54 9873377 Belliotti, TR; Brink, WA; Kesten, SR; Rubin, JR; Wustrow, DJ; Zoski, KT; Whetzel, SZ; Corbin, AE; Pugsley, TA; Heffner, TG; Wise, LD Parke-Davis Pharmaceutical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50070518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50070518&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9928335 103964379 CHEMBL35093 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50121760 Cc1ccc(cc1C)N1CCN(CC[C@@H]2NC(=O)c3ccccc23)CC1 InChI=1S/C22H27N3O/c1-16-7-8-18(15-17(16)2)25-13-11-24(12-14-25)10-9-21-19-5-3-4-6-20(19)22(26)23-21/h3-8,15,21H,9-14H2,1-2H3,(H,23,26)/t21-/m0/s1 WQEPZBNLBWDIRZ-NRFANRHFSA-N 50070514 (S)-3-{2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-yl]-ethyl}-2,3-dihydro-isoindol-1-one::3-{2-[4-(3,4-Dimethyl-phenyl)-piperazin-1-yl]-ethyl}-2,3-dihydro-isoindol-1-one (PD-18126)::CHEMBL37170::PD-172938::PD-18126 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 343 ChEMBL 10.1016/s0960-894x(98)00252-2 10.7270/Q2WH2P54 9873377 Belliotti, TR; Brink, WA; Kesten, SR; Rubin, JR; Wustrow, DJ; Zoski, KT; Whetzel, SZ; Corbin, AE; Pugsley, TA; Heffner, TG; Wise, LD Parke-Davis Pharmaceutical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50070514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50070514&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search RMZ 7AMJ 9798466 103964375 CHEMBL37170 ZINC03827164 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50125982 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 QZUDBNBUXVUHMW-UHFFFAOYSA-N 50001884 2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone::3-Hydroxy-2-phenyl-propionic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester::3-chloro-6-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine::8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine (Clozapine)::8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine( Clozepine )::8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Ciozapine)::8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Clopazine)::8-chloro-11-(4-methyl-piperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine::8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine::CHEMBL42::CHEMBL538973::CLOZAPINE::CLOZAPINE, 8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE::CLOZARIL::HF 1854::US10167256, Clozapine::US10752588, Compound Clozapine::US11498896, Compound Clozapine Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 19 ChEMBL 10.1021/jm9810396 10.7270/Q2QC02N8 9876110 Bolos, J; Anglada, L; Gubert, S; Planas, JM; Agut, J; Princep, M; De la Fuente, N; Sacristan, A; Ortiz, JA Centro de Investigación Grupo Ferrer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001884&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 2818 103916251 3766 CHEMBL42CHEMBL538973 DB00363 38 C06924 ZINC19796155 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50126043 Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12 InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3 RAPZEAPATHNIPO-UHFFFAOYSA-N 50001885 (risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one::1-(2-Allyl-phenoxy)-3-isopropylamino-propan-2-ol::2-(2-(4-(benzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-7,8,9,9a-tetrahydro-1H-pyrido[1,2-a]pyrimidin-4(6H)-one::2-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-6,7,8,8a-tetrahydro-5H-naphthalen-1-one::3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one::3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one::3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)::3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (risperidone)::3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one(risperidone)::5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-methyl-1,3-dihydro-indol-2-one(Norastemizole)::CHEMBL85::R 64 766::RISPERDAL::RISPERIDONE::US10167256, Risperidone::US10174011, risperidone::US10259786, Risperidone::US10501452, Compound risperidone::US8802672, Risperidone::WO2023288027, Cmpd Risperidone Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 25 ChEMBL 10.1021/jm9810396 10.7270/Q2QC02N8 9876110 Bolos, J; Anglada, L; Gubert, S; Planas, JM; Agut, J; Princep, M; De la Fuente, N; Sacristan, A; Ortiz, JA Centro de Investigación Grupo Ferrer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001885&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 8NU 6A93,6CM4 5073 103916252 8871 CHEMBL85 DB00734 96 ZINC00538312 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50141708 O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1 InChI=1S/C18H18N2O2/c21-18-9-8-15-7-6-14(12-17(15)22-18)13-19-10-11-20-16-4-2-1-3-5-16/h1-9,12,19-20H,10-11,13H2 RNNKCHJUBXFBQB-UHFFFAOYSA-N 50080797 7-[(2-Phenylamino-ethylamino)-methyl]-chromen-2-one::CHEMBL332154 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 2670 ChEMBL 10.1021/jm990266k 10.7270/Q2RN371G 10479303 Kesten, SR; Heffner, TG; Johnson, SJ; Pugsley, TA; Wright, JL; Wise, LD Warner-Lambert Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080797&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9926143 103980921 CHEMBL332154 ZINC02003124 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50139953 COc1ccccc1N1CCC(CNCC2COc3ccc(Cl)cc3O2)CC1 InChI=1S/C22H27ClN2O3/c1-26-20-5-3-2-4-19(20)25-10-8-16(9-11-25)13-24-14-18-15-27-21-7-6-17(23)12-22(21)28-18/h2-7,12,16,18,24H,8-11,13-15H2,1H3 QHLRKDSRGUZHSH-UHFFFAOYSA-N 50079939 (7-Chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1-(2-methoxy-phenyl)-piperidin-4-ylmethyl]-amine::CHEMBL418854 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >500 ChEMBL 10.1021/jm9910122 10.7270/Q2WH2P6K 10464021 Birch, AM; Bradley, PA; Gill, JC; Kerrigan, F; Needham, PL Knoll Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079939&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9865858 103972053 CHEMBL418854 ZINC03828998 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50152485 C1CC(c2cnc[nH]2)c2sccc2C1 InChI=1S/C11H12N2S/c1-2-8-4-5-14-11(8)9(3-1)10-6-12-7-13-10/h4-7,9H,1-3H2,(H,12,13) BYGZPILZIWTFRA-UHFFFAOYSA-N 50085679 4-(4,5,6,7-Tetrahydro-benzo[b]thiophen-7-yl)-1H-imidazole::CHEMBL286269 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.350000 ChEMBL 10.1021/jm990569e 10.7270/Q2251HDX 10715142 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085679&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9837136 103985089 CHEMBL286269 ZINC03923488 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50152488 Clc1cccc(Cl)c1N=C1NCCN1 InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) GJSURZIOUXUGAL-UHFFFAOYSA-N 50016897 2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2)::2-(2,6-dichloroanilino)-2-imidazoline::CLONIDINE::N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine::clonidine (amino form) Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.390000 ChEMBL 10.1021/jm990569e 10.7270/Q2251HDX 10715142 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016897&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search CLU 2PNC,7AWW 2803 103928231 46632 516 ZINC00896484 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50152489 C1Cc2sccc2C(=C1)c1cnc[nH]1 InChI=1S/C11H10N2S/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1/h2,4-7H,1,3H2,(H,12,13) BAADWHDQAKDYLX-UHFFFAOYSA-N 50085680 4-(6,7-Dihydro-benzo[b]thiophen-4-yl)-1H-imidazole::CHEMBL286246 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1.5 ChEMBL 10.1021/jm990569e 10.7270/Q2251HDX 10715142 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085680&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9815610 103985090 CHEMBL286246 ZINC04805849 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50152493 C1Cc2ccsc2C(=C1)c1cnc[nH]1 InChI=1S/C11H10N2S/c1-2-8-4-5-14-11(8)9(3-1)10-6-12-7-13-10/h3-7H,1-2H2,(H,12,13) VXOQWXOKZCWYOS-UHFFFAOYSA-N 50085682 4-(4,5-Dihydro-benzo[b]thiophen-7-yl)-1H-imidazole::CHEMBL30955 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 3 ChEMBL 10.1021/jm990569e 10.7270/Q2251HDX 10715142 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085682&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9837106 103985092 CHEMBL30955 ZINC00024135 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50152498 C1CC(c2cnc[nH]2)c2ccsc2C1 InChI=1S/C11H12N2S/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1/h4-8H,1-3H2,(H,12,13) BFSPTAYUYXLBEU-UHFFFAOYSA-N 50085678 4-(4,5,6,7-Tetrahydro-benzo[b]thiophen-4-yl)-1H-imidazole::CHEMBL284213 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.560000 ChEMBL 10.1021/jm990569e 10.7270/Q2251HDX 10715142 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085678&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9815633 103985088 CHEMBL284213 ZINC03923482 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50152500 Cc1sc(C)c2c1CCC=C2c1cnc[nH]1 InChI=1S/C13H14N2S/c1-8-10-4-3-5-11(12-6-14-7-15-12)13(10)9(2)16-8/h5-7H,3-4H2,1-2H3,(H,14,15) RLKWQKZPCMICPS-UHFFFAOYSA-N 50085677 4-(1,3-Dimethyl-6,7-dihydro-benzo[c]thiophen-4-yl)-1H-imidazole::CHEMBL284795 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.008600 ChEMBL 10.1021/jm990569e 10.7270/Q2251HDX 10715142 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085677&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10220232 103985087 CHEMBL284795 ZINC00024132 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50152507 Cc1sc(C)c2C(CCCc12)c1cnc[nH]1 InChI=1S/C13H16N2S/c1-8-10-4-3-5-11(12-6-14-7-15-12)13(10)9(2)16-8/h6-7,11H,3-5H2,1-2H3,(H,14,15) AOQYWVCOSJELMS-UHFFFAOYSA-N 50085676 4-(1,3-Dimethyl-4,5,6,7-tetrahydro-benzo[c]thiophen-4-yl)-1H-imidazole::CHEMBL30739 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 2.9 ChEMBL 10.1021/jm990569e 10.7270/Q2251HDX 10715142 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085676&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9816063 103985086 CHEMBL30739 ZINC03923487 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50152508 c1cc2c(cccc2s1)-c1c[nH]cn1 InChI=1S/C11H8N2S/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1/h1-7H,(H,12,13) QRRRICPYXPJYEH-UHFFFAOYSA-N 50085681 4-Benzo[b]thiophen-4-yl-1H-imidazole::CHEMBL30534 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 2.6 ChEMBL 10.1021/jm990569e 10.7270/Q2251HDX 10715142 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085681&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10176567 103985091 CHEMBL30534 ZINC00024131 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50152511 C[C@H](c1cnc[nH]1)c1cccc(C)c1C InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1 CUHVIMMYOGQXCV-NSHDSACASA-N 50085683 (+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole::4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole::CHEMBL778::DEXMEDETOMIDINE::MPV 1440 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.015000 ChEMBL 10.1021/jm990569e 10.7270/Q2251HDX 10715142 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085683&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5311068 103985093 48552 CHEMBL778 ZINC04632106 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155021 Cc1sc(C)c2C(CCCc12)c1cnc[nH]1 InChI=1S/C13H16N2S/c1-8-10-4-3-5-11(12-6-14-7-15-12)13(10)9(2)16-8/h6-7,11H,3-5H2,1-2H3,(H,14,15) AOQYWVCOSJELMS-UHFFFAOYSA-N 50085676 4-(1,3-Dimethyl-4,5,6,7-tetrahydro-benzo[c]thiophen-4-yl)-1H-imidazole::CHEMBL30739 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 2.9 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085676&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9816063 103985086 CHEMBL30739 ZINC03923487 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155022 C1Cc2ccsc2C(=C1)c1cnc[nH]1 InChI=1S/C11H10N2S/c1-2-8-4-5-14-11(8)9(3-1)10-6-12-7-13-10/h3-7H,1-2H2,(H,12,13) VXOQWXOKZCWYOS-UHFFFAOYSA-N 50085682 4-(4,5-Dihydro-benzo[b]thiophen-7-yl)-1H-imidazole::CHEMBL30955 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 224 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085682&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9837106 103985092 CHEMBL30955 ZINC00024135 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155023 C1CC(c2cnc[nH]2)c2ccsc2C1 InChI=1S/C11H12N2S/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1/h4-8H,1-3H2,(H,12,13) BFSPTAYUYXLBEU-UHFFFAOYSA-N 50085678 4-(4,5,6,7-Tetrahydro-benzo[b]thiophen-4-yl)-1H-imidazole::CHEMBL284213 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.56 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085678&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9815633 103985088 CHEMBL284213 ZINC03923482 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155025 C1CC(c2cnc[nH]2)c2sccc2C1 InChI=1S/C11H12N2S/c1-2-8-4-5-14-11(8)9(3-1)10-6-12-7-13-10/h4-7,9H,1-3H2,(H,12,13) BYGZPILZIWTFRA-UHFFFAOYSA-N 50085679 4-(4,5,6,7-Tetrahydro-benzo[b]thiophen-7-yl)-1H-imidazole::CHEMBL286269 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.35 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085679&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9837136 103985089 CHEMBL286269 ZINC03923488 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155027 c1cc2c(cccc2s1)-c1c[nH]cn1 InChI=1S/C11H8N2S/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1/h1-7H,(H,12,13) QRRRICPYXPJYEH-UHFFFAOYSA-N 50085681 4-Benzo[b]thiophen-4-yl-1H-imidazole::CHEMBL30534 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 277 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085681&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10176567 103985091 CHEMBL30534 ZINC00024131 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155029 C1Cc2sccc2C(=C1)c1cnc[nH]1 InChI=1S/C11H10N2S/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1/h2,4-7H,1,3H2,(H,12,13) BAADWHDQAKDYLX-UHFFFAOYSA-N 50085680 4-(6,7-Dihydro-benzo[b]thiophen-4-yl)-1H-imidazole::CHEMBL286246 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1.5 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085680&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9815610 103985090 CHEMBL286246 ZINC04805849 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155032 C1CC(c2cnc[nH]2)c2ccsc2C1 InChI=1S/C11H12N2S/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1/h4-8H,1-3H2,(H,12,13) BFSPTAYUYXLBEU-UHFFFAOYSA-N 50085678 4-(4,5,6,7-Tetrahydro-benzo[b]thiophen-4-yl)-1H-imidazole::CHEMBL284213 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 27 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085678&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9815633 103985088 CHEMBL284213 ZINC03923482 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155034 C[C@H](c1cnc[nH]1)c1cccc(C)c1C InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1 CUHVIMMYOGQXCV-NSHDSACASA-N 50085683 (+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole::4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole::CHEMBL778::DEXMEDETOMIDINE::MPV 1440 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 5 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085683&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5311068 103985093 48552 CHEMBL778 ZINC04632106 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155036 c1cc2c(cccc2s1)-c1c[nH]cn1 InChI=1S/C11H8N2S/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1/h1-7H,(H,12,13) QRRRICPYXPJYEH-UHFFFAOYSA-N 50085681 4-Benzo[b]thiophen-4-yl-1H-imidazole::CHEMBL30534 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 2.6 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085681&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10176567 103985091 CHEMBL30534 ZINC00024131 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155037 Clc1cccc(Cl)c1N=C1NCCN1 InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) GJSURZIOUXUGAL-UHFFFAOYSA-N 50016897 2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2)::2-(2,6-dichloroanilino)-2-imidazoline::CLONIDINE::N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine::clonidine (amino form) Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 853 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016897&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search CLU 2PNC,7AWW 2803 103928231 46632 516 ZINC00896484 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155041 Cc1sc(C)c2c1CCC=C2c1cnc[nH]1 InChI=1S/C13H14N2S/c1-8-10-4-3-5-11(12-6-14-7-15-12)13(10)9(2)16-8/h5-7H,3-4H2,1-2H3,(H,14,15) RLKWQKZPCMICPS-UHFFFAOYSA-N 50085677 4-(1,3-Dimethyl-6,7-dihydro-benzo[c]thiophen-4-yl)-1H-imidazole::CHEMBL284795 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 25 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085677&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10220232 103985087 CHEMBL284795 ZINC00024132 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155042 Cc1sc(C)c2C(CCCc12)c1cnc[nH]1 InChI=1S/C13H16N2S/c1-8-10-4-3-5-11(12-6-14-7-15-12)13(10)9(2)16-8/h6-7,11H,3-5H2,1-2H3,(H,14,15) AOQYWVCOSJELMS-UHFFFAOYSA-N 50085676 4-(1,3-Dimethyl-4,5,6,7-tetrahydro-benzo[c]thiophen-4-yl)-1H-imidazole::CHEMBL30739 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 68 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085676&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9816063 103985086 CHEMBL30739 ZINC03923487 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155043 C1Cc2sccc2C(=C1)c1cnc[nH]1 InChI=1S/C11H10N2S/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1/h2,4-7H,1,3H2,(H,12,13) BAADWHDQAKDYLX-UHFFFAOYSA-N 50085680 4-(6,7-Dihydro-benzo[b]thiophen-4-yl)-1H-imidazole::CHEMBL286246 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 254 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085680&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9815610 103985090 CHEMBL286246 ZINC04805849 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155046 C[C@H](c1cnc[nH]1)c1cccc(C)c1C InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1 CUHVIMMYOGQXCV-NSHDSACASA-N 50085683 (+)-4-((S)-alpha,2,3-trimethylbenzyl)imidazole::4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole::CHEMBL778::DEXMEDETOMIDINE::MPV 1440 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.015 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085683&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 5311068 103985093 48552 CHEMBL778 ZINC04632106 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155049 Cc1sc(C)c2c1CCC=C2c1cnc[nH]1 InChI=1S/C13H14N2S/c1-8-10-4-3-5-11(12-6-14-7-15-12)13(10)9(2)16-8/h5-7H,3-4H2,1-2H3,(H,14,15) RLKWQKZPCMICPS-UHFFFAOYSA-N 50085677 4-(1,3-Dimethyl-6,7-dihydro-benzo[c]thiophen-4-yl)-1H-imidazole::CHEMBL284795 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.0086 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085677&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10220232 103985087 CHEMBL284795 ZINC00024132 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155051 C1Cc2ccsc2C(=C1)c1cnc[nH]1 InChI=1S/C11H10N2S/c1-2-8-4-5-14-11(8)9(3-1)10-6-12-7-13-10/h3-7H,1-2H2,(H,12,13) VXOQWXOKZCWYOS-UHFFFAOYSA-N 50085682 4-(4,5-Dihydro-benzo[b]thiophen-7-yl)-1H-imidazole::CHEMBL30955 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 3 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085682&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9837106 103985092 CHEMBL30955 ZINC00024135 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50155052 Clc1cccc(Cl)c1N=C1NCCN1 InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) GJSURZIOUXUGAL-UHFFFAOYSA-N 50016897 2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2)::2-(2,6-dichloroanilino)-2-imidazoline::CLONIDINE::N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine::clonidine (amino form) Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.39 ChEMBL 10.1021/jm000128r 10.7270/Q2C828HK 10753480 Ross, TM; Jetter, MC; McDonnell, ME; Boyd, RE; Connelly, CD; Martinez, RP; Lewis, MA; Codd, EE; Raffa, RB; Reitz, AB The R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016897&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search CLU 2PNC,7AWW 2803 103928231 46632 516 ZINC00896484 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50261497 Brc1cccc2c3CCNCc3[nH]c12 InChI=1S/C11H11BrN2/c12-9-3-1-2-8-7-4-5-13-6-10(7)14-11(8)9/h1-3,13-14H,4-6H2 QDAJATJOFYZEDN-UHFFFAOYSA-N 50136494 8-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline::CHEMBL6857 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 460 ChEMBL 10.1016/j.bmcl.2003.11.078 10.7270/Q2SB456G 15013009 Glennon, RA; Grella, B; Tyacke, RJ; Lau, A; Westaway, J; Hudson, AL Virginia Commonwealth University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50136494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50136494&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10467319 104026780 CHEMBL6857 ZINC25965899 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301196 FCC1Cc2ccc(cc2CN1)S(=O)(=O)NCC(F)(F)F InChI=1S/C12H14F4N2O2S/c13-5-10-3-8-1-2-11(4-9(8)6-17-10)21(19,20)18-7-12(14,15)16/h1-2,4,10,17-18H,3,5-7H2 GFLULHGGFBMVRA-UHFFFAOYSA-N 13026 3-(fluoromethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide::7-sulfonamide-THIQ 16::CHEMBL178695 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1200000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13026&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10019263 46513450 CHEMBL178695 ZINC13581893 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301197 FC[C@H]1Cc2ccc(cc2CN1)S(=O)(=O)NCC(F)(F)F InChI=1S/C12H14F4N2O2S/c13-5-10-3-8-1-2-11(4-9(8)6-17-10)21(19,20)18-7-12(14,15)16/h1-2,4,10,17-18H,3,5-7H2/t10-/m1/s1 GFLULHGGFBMVRA-SNVBAGLBSA-N 50163104 (R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (2,2,2-trifluoro-ethyl)-amide::CHEMBL425522 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1000000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50163104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50163104&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10471609 104049197 CHEMBL425522 ZINC13581893 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301199 CCCNS(=O)(=O)c1ccc2CC(CF)NCc2c1 InChI=1S/C13H19FN2O2S/c1-2-5-16-19(17,18)13-4-3-10-6-12(8-14)15-9-11(10)7-13/h3-4,7,12,15-16H,2,5-6,8-9H2,1H3 SSUCQFQOXPPRKP-UHFFFAOYSA-N 13031 3-(fluoromethyl)-N-propyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide::7-sulfonamide-THIQ 21::CHEMBL435536 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 610000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13031&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10108068 46513455 CHEMBL435536 ZINC13581865 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301200 FCC1Cc2ccc(cc2CN1)S(=O)(=O)NCCC(F)(F)F InChI=1S/C13H16F4N2O2S/c14-7-11-5-9-1-2-12(6-10(9)8-18-11)22(20,21)19-4-3-13(15,16)17/h1-2,6,11,18-19H,3-5,7-8H2 BBUDQLKRZPRPFD-UHFFFAOYSA-N 13028 3-(fluoromethyl)-N-(3,3,3-trifluoropropyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide::7-sulfonamide-THIQ 18::CHEMBL177621 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 660000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13028&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search FTS 2G71 11394776 46513452 CHEMBL177621 ZINC13581899 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301201 COCCCNS(=O)(=O)c1ccc2C[C@H](CF)NCc2c1 InChI=1S/C14H21FN2O3S/c1-20-6-2-5-17-21(18,19)14-4-3-11-7-13(9-15)16-10-12(11)8-14/h3-4,8,13,16-17H,2,5-7,9-10H2,1H3/t13-/m1/s1 DUVDGPSZMWUUNP-CYBMUJFWSA-N 50163106 (R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (3-methoxy-propyl)-amide::CHEMBL174274 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 680000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50163106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50163106&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 11772571 104049199 CHEMBL174274 ZINC13581884 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301205 CCCNS(=O)(=O)c1ccc2C[C@H](CF)NCc2c1 InChI=1S/C13H19FN2O2S/c1-2-5-16-19(17,18)13-4-3-10-6-12(8-14)15-9-11(10)7-13/h3-4,7,12,15-16H,2,5-6,8-9H2,1H3/t12-/m1/s1 SSUCQFQOXPPRKP-GFCCVEGCSA-N 50163107 (R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid propylamide::CHEMBL179298 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 570000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50163107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50163107&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 11438678 104049200 CHEMBL179298 ZINC13581865 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301208 NS(=O)(=O)c1ccc2CC(CF)NCc2c1 InChI=1S/C10H13FN2O2S/c11-5-9-3-7-1-2-10(16(12,14)15)4-8(7)6-13-9/h1-2,4,9,13H,3,5-6H2,(H2,12,14,15) JRESBJUYAQJNMA-UHFFFAOYSA-N 13022 3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide::7-sulfonamide-THIQ 12::CHEMBL95873 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 680000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13022&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10399576 46513446 CHEMBL95873 ZINC13517589 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301209 FCC1Cc2ccc(cc2CN1)S(=O)(=O)Nc1ccc(Cl)cc1 InChI=1S/C16H16ClFN2O2S/c17-13-2-4-14(5-3-13)20-23(21,22)16-6-1-11-7-15(9-18)19-10-12(11)8-16/h1-6,8,15,19-20H,7,9-10H2 ZVBJVGBGWLUEOH-UHFFFAOYSA-N 13024 7-sulfonamide-THIQ 14::CHEMBL290890::N-(4-chlorophenyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 140000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13024&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10089519 46513448 CHEMBL290890 ZINC13517581 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301211 FC[C@@H]1Cc2ccc(cc2CN1)S(=O)(=O)Nc1ccc(Cl)cc1 InChI=1S/C16H16ClFN2O2S/c17-13-2-4-14(5-3-13)20-23(21,22)16-6-1-11-7-15(9-18)19-10-12(11)8-16/h1-6,8,15,19-20H,7,9-10H2/t15-/m0/s1 ZVBJVGBGWLUEOH-HNNXBMFYSA-N 50081955 (S)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (4-chloro-phenyl)-amide::CHEMBL135957 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 150000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081955&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10618144 103981888 CHEMBL135957 ZINC13517577 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301214 CCNS(=O)(=O)c1ccc2CC(CF)NCc2c1 InChI=1S/C12H17FN2O2S/c1-2-15-18(16,17)12-4-3-9-5-11(7-13)14-8-10(9)6-12/h3-4,6,11,14-15H,2,5,7-8H2,1H3 UKWVXNMBQJTJOS-UHFFFAOYSA-N 13030 7-sulfonamide-THIQ 20::CHEMBL177861::N-ethyl-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 550000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13030&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 11196556 46513454 CHEMBL177861 ZINC13581860 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301215 FC[C@H]1Cc2ccc(cc2CN1)S(=O)(=O)NCCC(F)(F)F InChI=1S/C13H16F4N2O2S/c14-7-11-5-9-1-2-12(6-10(9)8-18-11)22(20,21)19-4-3-13(15,16)17/h1-2,6,11,18-19H,3-5,7-8H2/t11-/m1/s1 BBUDQLKRZPRPFD-LLVKDONJSA-N 50163108 (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE::(R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (3,3,3-trifluoro-propyl)-amide::CHEMBL177101 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 670000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50163108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50163108&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search FTS 2G71 11349402 104049201 CHEMBL177101 DB07798 ZINC13581899 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301218 NS(=O)(=O)c1ccc2C[C@H](CF)NCc2c1 InChI=1S/C10H13FN2O2S/c11-5-9-3-7-1-2-10(16(12,14)15)4-8(7)6-13-9/h1-2,4,9,13H,3,5-6H2,(H2,12,14,15)/t9-/m1/s1 JRESBJUYAQJNMA-SECBINFHSA-N 50163109 (R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid amide::CHEMBL361203 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 700000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50163109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50163109&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 11460195 104049202 CHEMBL361203 ZINC13517589 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301219 FC[C@H]1Cc2ccc(cc2CN1)S(=O)(=O)Nc1ccc(Cl)cc1 InChI=1S/C16H16ClFN2O2S/c17-13-2-4-14(5-3-13)20-23(21,22)16-6-1-11-7-15(9-18)19-10-12(11)8-16/h1-6,8,15,19-20H,7,9-10H2/t15-/m1/s1 ZVBJVGBGWLUEOH-OAHLLOKOSA-N 50081954 (R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (4-chloro-phenyl)-amide::CHEMBL135959 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 140000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081954&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10784360 103981887 CHEMBL135959 ZINC13517581 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301220 CCNS(=O)(=O)c1ccc2C[C@H](CF)NCc2c1 InChI=1S/C12H17FN2O2S/c1-2-15-18(16,17)12-4-3-9-5-11(7-13)14-8-10(9)6-12/h3-4,6,11,14-15H,2,5,7-8H2,1H3/t11-/m1/s1 UKWVXNMBQJTJOS-LLVKDONJSA-N 50163105 (R)-3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid ethylamide::CHEMBL175094 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 550000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50163105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50163105&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 11312887 104049198 CHEMBL175094 ZINC13581860 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301221 FCC1Cc2ccc(cc2CN1)S(=O)(=O)N1CCSCC1 InChI=1S/C14H19FN2O2S2/c15-9-13-7-11-1-2-14(8-12(11)10-16-13)21(18,19)17-3-5-20-6-4-17/h1-2,8,13,16H,3-7,9-10H2 SBUKSNPHYWXCDG-UHFFFAOYSA-N 50151343 (+)-3-(fluoromethyl)-7-(thiomorpholinosulfonyl)-1,2,3,4-tetrahydroisoquinoline::3-Fluoromethyl-7-(thiomorpholine-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline::CHEMBL355581 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 190000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50151343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50151343&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search F21 2OPB,2G72 11337570 104039521 CHEMBL355581 ZINC13581950 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301222 FC[C@H]1Cc2ccc(cc2CN1)S(=O)(=O)N1CCSCC1 InChI=1S/C14H19FN2O2S2/c15-9-13-7-11-1-2-14(8-12(11)10-16-13)21(18,19)17-3-5-20-6-4-17/h1-2,8,13,16H,3-7,9-10H2/t13-/m1/s1 SBUKSNPHYWXCDG-CYBMUJFWSA-N 50163110 (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE::(R)-3-Fluoromethyl-7-(thiomorpholine-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline::CHEMBL177749 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 200000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50163110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50163110&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search F21 2OPB,2G72 11485425 104049203 CHEMBL177749 DB07739 ZINC13581950 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50301223 COCCCNS(=O)(=O)c1ccc2CC(CF)NCc2c1 InChI=1S/C14H21FN2O3S/c1-20-6-2-5-17-21(18,19)14-4-3-11-7-13(9-15)16-10-12(11)8-14/h3-4,8,13,16-17H,2,5-7,9-10H2,1H3 DUVDGPSZMWUUNP-UHFFFAOYSA-N 50151341 3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (3-methoxy-propyl)-amide::CHEMBL177936 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 750000 ChEMBL 10.1021/jm049594x 10.7270/Q2TX3DW4 15771426 Grunewald, GL; Romero, FA; Criscione, KR University of Kansas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50151341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50151341&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 11325652 104039519 CHEMBL177936 ZINC13581884 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50346986 COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1 InChI=1S/C22H31N3O3S/c1-19-9-11-20(12-10-19)29(26,27)23-13-5-6-14-24-15-17-25(18-16-24)21-7-3-4-8-22(21)28-2/h3-4,7-12,23H,5-6,13-18H2,1-2H3 YMFRPPUSWRHMPF-UHFFFAOYSA-N 50187381 CHEMBL209324::N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methylbenzenesulfonamide Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 12 ChEMBL 10.1021/jm0508641 10.7270/Q2319VHC 16722631 Becker, OM; Dhanoa, DS; Marantz, Y; Chen, D; Shacham, S; Cheruku, S; Heifetz, A; Mohanty, P; Fichman, M; Sharadendu, A; Nudelman, R; Kauffman, M; Noiman, S Predix Pharmaceuticals Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50187381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50187381&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 398712 104071380 CHEMBL209324 ZINC04364558 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50368644 Cc1noc2c(nn(CCCN3CCN(CC3)c3cccc(Cl)c3)c(=O)c12)-c1ccccc1 InChI=1S/C25H26ClN5O2/c1-18-22-24(33-28-18)23(19-7-3-2-4-8-19)27-31(25(22)32)12-6-11-29-13-15-30(16-14-29)21-10-5-9-20(26)17-21/h2-5,7-10,17H,6,11-16H2,1H3 NKYYDZOPTBYOLZ-UHFFFAOYSA-N 50201046 5-{3-[4-(3-chlorophenyl)hexahydro-1-pyrazinyl]propyl}-3-methyl-7-phenyl-4,5-dihydroisoxazolo[4,5-d]pyridazin-4-one::5-{[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-methyl-7-phenylisoxazolo[4,5-d]pyridazinon-4-(5H)-one::CHEMBL10161 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >1000 ChEMBL 10.1021/jm060743g 10.7270/Q29K49W5 17181165 Cesari, N; Biancalani, C; Vergelli, C; Dal Piaz, V; Graziano, A; Biagini, P; Ghelardini, C; Galeotti, N; Giovannoni, MP Dipartimento di Scienze Farmaceutiche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50201046&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 11754159 104080992 CHEMBL10161 ZINC01491937 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50459873 ONC(=N)CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12 InChI=1S/C17H19FN6O/c18-12-3-4-14-13(10-12)20-17(15-2-1-5-24(14)15)23-8-6-22(7-9-23)11-16(19)21-25/h1-5,10,25H,6-9,11H2,(H2,19,21) OHKKNUFVKFSRIU-UHFFFAOYSA-N 50258431 CHEMBL523716::[4-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)piperazin-1-yl]hydroxyacetamidine Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 ChEMBL 10.1021/jm900018b 10.7270/Q2M908K7 19425598 Morelli, E; Gemma, S; Budriesi, R; Campiani, G; Novellino, E; Fattorusso, C; Catalanotti, B; Coccone, SS; Ros, S; Borrelli, G; Persico, M; Fiorini, I; Nacci, V; Ioan, P; Chiarini, A; Hamon, M; Cagnotto, A; Mennini, T; Fracasso, C; Colovic, M; Caccia, S; Butini, S European Research Centre for Drug Discovery and Development (NatSynDrugs) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258431&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 44157734 104109114 CHEMBL523716 ZINC40953018 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50459879 N[C@@H](CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12)C(O)=O InChI=1S/C18H20FN5O2/c19-12-3-4-15-14(10-12)21-17(16-2-1-5-24(15)16)23-8-6-22(7-9-23)11-13(20)18(25)26/h1-5,10,13H,6-9,11,20H2,(H,25,26)/t13-/m0/s1 CTKOQDQPYZTIFY-ZDUSSCGKSA-N 50258462 (S)-2-Amino-3-[4-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)piperazin-1-yl]propionic Acid::CHEMBL511555 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 ChEMBL 10.1021/jm900018b 10.7270/Q2M908K7 19425598 Morelli, E; Gemma, S; Budriesi, R; Campiani, G; Novellino, E; Fattorusso, C; Catalanotti, B; Coccone, SS; Ros, S; Borrelli, G; Persico, M; Fiorini, I; Nacci, V; Ioan, P; Chiarini, A; Hamon, M; Cagnotto, A; Mennini, T; Fracasso, C; Colovic, M; Caccia, S; Butini, S European Research Centre for Drug Discovery and Development (NatSynDrugs) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258462&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 44157942 104109134 CHEMBL511555 ZINC40401805 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50459885 N[C@H](CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12)C(O)=O InChI=1S/C18H20FN5O2/c19-12-3-4-15-14(10-12)21-17(16-2-1-5-24(15)16)23-8-6-22(7-9-23)11-13(20)18(25)26/h1-5,10,13H,6-9,11,20H2,(H,25,26)/t13-/m1/s1 CTKOQDQPYZTIFY-CYBMUJFWSA-N 50258495 (R)-2-Amino-3-[4-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)piperazin-1-yl]propionic Acid::CHEMBL466462 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 ChEMBL 10.1021/jm900018b 10.7270/Q2M908K7 19425598 Morelli, E; Gemma, S; Budriesi, R; Campiani, G; Novellino, E; Fattorusso, C; Catalanotti, B; Coccone, SS; Ros, S; Borrelli, G; Persico, M; Fiorini, I; Nacci, V; Ioan, P; Chiarini, A; Hamon, M; Cagnotto, A; Mennini, T; Fracasso, C; Colovic, M; Caccia, S; Butini, S European Research Centre for Drug Discovery and Development (NatSynDrugs) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258495&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 44157837 104109152 CHEMBL466462 ZINC40395344 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50483103 COc1cc(N)c(Cl)cc1C(=O)NC1C2CC3CN(CC13)C2 InChI=1S/C16H20ClN3O2/c1-22-14-4-13(18)12(17)3-10(14)16(21)19-15-9-2-8-5-20(6-9)7-11(8)15/h3-4,8-9,11,15H,2,5-7,18H2,1H3,(H,19,21) MRKYTIJPEALHEE-UHFFFAOYSA-N 50289986 4-Amino-N-(1-aza-tricyclo[3.3.1.0*3,7*]non-4-yl)-5-chloro-2-methoxy-benzamide; hydrochloride::CHEMBL558226::SC-52491 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 ChEMBL 10.1016/S0960-894X(97)00408-3 10.7270/Q27S7NSJ Becker, DP; Nosal, R; Villamil, CI; Gullikson, G; Moummi, C; Yang, DC; Flynn, DL TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50289986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50289986&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 9885123 104131557 CHEMBL558226 ZINC13891420 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50753978 Cc1nc[nH]c1Cc1nc(cs1)-c1ccccc1 InChI=1S/C14H13N3S/c1-10-12(16-9-15-10)7-14-17-13(8-18-14)11-5-3-2-4-6-11/h2-6,8-9H,7H2,1H3,(H,15,16) SDWUPSHVUBKGKN-UHFFFAOYSA-N 50014154 2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiazole::CHEMBL38465 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >1000 ChEMBL 10.1021/jm00172a006 10.7270/Q2H995S5 2213824 Rosen, T; Nagel, AA; Rizzi, JP; Ives, JL; Daffeh, JB; Ganong, AH; Guarino, K; Heym, J; McLean, S; Nowakowski, JT Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50014154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50014154&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 14742527 103926176 CHEMBL38465 ZINC00004346 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50772595 Oc1cc2CC[C@H]3NCc4ccccc4[C@@H]3c2cc1O InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m1/s1 BGOQGUHWXBGXJW-RHSMWYFYSA-N 50010686 (6aR,12bS)-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydro-benzo[a]phenanthridinium::(6aR,12bS)-5,6,6a,7,8,12b-Hexahydro-benzo[a]phenanthridine-10,11-diol::10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydro-benzo[a]phenanthridinium(DHX)::5,6,6a,7,8,12b-Hexahydro-benzo[a]phenanthridine-10,11-diol::CHEMBL25856::dihydrexidine Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >3000 ChEMBL 10.1021/jm00018a002 10.7270/Q26M37G0 7658429 Michaelides, MR; Hong, Y; DiDomenico, S; Asin, KE; Britton, DR; Lin, CW; Williams, M; Shiosaki, K Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010686&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 6603820 103923432 CHEMBL25856 ZINC25758512 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50775012 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2cc(F)ccc12)C(C)=O InChI=1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3 XMXHEBAFVSFQEX-UHFFFAOYSA-N 50034043 1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-propoxy}-3-methoxy-phenyl)-ethanone::CHEMBL14376::ILOPERIDONE Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 0.40 ChEMBL 10.1021/jm00007a009 10.7270/Q2S75H08 7707315 Strupczewski, JT; Bordeau, KJ; Chiang, Y; Glamkowski, EJ; Conway, PG; Corbett, R; Hartman, HB; Szewczak, MR; Wilmot, CA; Helsley, GC Hoechst-Roussel Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034043&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 71360 103942259 65173 CHEMBL14376 DB04946 87 ZINC01548097 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50773178 COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12 InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16-,19+/m0/s1 GRTOGORTSDXSFK-BMYCAMMWSA-N 50030622 (7aS,8S,11aS,12aR)-8-Methyl-5,6,7a,8,11a,12,12a,13-octahydro-7H-9-oxa-6a,13-diaza-indeno[2,1-a]anthracene-11-carboxylic acid methyl ester::AKUAMMIGINE::CHEMBL122404 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1210 ChEMBL 10.1021/jm00019a001 10.7270/Q2SB46C4 7562902 Ruffolo, RR; Bondinell, W; Hieble, JP SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030622&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 1268096 103939471 CHEMBL122404 ZINC53174616 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50780591 Oc1cc2CC[C@@H]3NCc4ccsc4[C@H]3c2cc1O InChI=1S/C15H15NO2S/c17-12-5-8-1-2-11-14(10(8)6-13(12)18)15-9(7-16-11)3-4-19-15/h3-6,11,14,16-18H,1-2,7H2/t11-,14-/m0/s1 YWMQJPWBNVVTRC-FZMZJTMJSA-N 50057837 (5aS,11bS)-4,5,5a,6,7,11b-Hexahydro-1-thia-5-aza-cyclopenta[c]phenanthrene-9,10-diol::CHEMBL288536 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >5000 ChEMBL 10.1021/jm970038v 10.7270/Q2Z89D2B 9171869 Michaelides, MR; Hong, Y; DiDomenico, S; Bayburt, EK; Asin, KE; Britton, DR; Lin, CW; Shiosaki, K Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50057837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50057837&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10540201 103953816 CHEMBL288536 ZINC13762002 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50772057 COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c1cc(Cl)c(N)cc1OC InChI=1S/C23H29ClFN3O4/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29) DCSUBABJRXZOMT-UHFFFAOYSA-N 50005836 4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl]-3-methoxy-piperidin-4-yl}-2-methoxy-benzamide::4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide::CHEMBL560739::CISAPRIDE::PROPULSID::US10167299, Cisapride::US10800776, Example Cisapride::US9221790, Cisapride::cid_5311047 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 30 ChEMBL 10.1021/jm00013a009 10.7270/Q2W959VM 7608898 Buchheit, KH; Gamse, R; Giger, R; Hoyer, D; Klein, F; Kloppner, E; Pfannkuche, HJ; Mattes, H Sandoz Pharma Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005836&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 2769 103919261 CHEMBL560739 240 C06910 ZINC03830564 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50813760 Clc1ccc(N2CCN(CCCCNC(=O)c3cc4ccccc4cn3)CC2)c(Cl)c1 InChI=1S/C24H26Cl2N4O/c25-20-7-8-23(21(26)16-20)30-13-11-29(12-14-30)10-4-3-9-27-24(31)22-15-18-5-1-2-6-19(18)17-28-22/h1-2,5-8,15-17H,3-4,9-14H2,(H,27,31) BJILZOKLMRTDFN-UHFFFAOYSA-N 50131921 CHEMBL340641::Isoquinoline-3-carboxylic acid {4-[4-(2,4-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1047 ChEMBL 10.1021/jm0211220 10.7270/Q2H132RF 12930145 Campiani, G; Butini, S; Trotta, F; Fattorusso, C; Catalanotti, B; Aiello, F; Gemma, S; Nacci, V; Novellino, E; Stark, JA; Cagnotto, A; Fumagalli, E; Carnovali, F; Cervo, L; Mennini, T Universit£ di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131921&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 11091738 104022946 CHEMBL340641 ZINC13525839 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50813769 COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1 InChI=1S/C24H29N3O3/c1-29-22-11-5-3-9-20(22)27-16-14-26(15-17-27)13-7-6-12-25-24(28)23-18-19-8-2-4-10-21(19)30-23/h2-5,8-11,18H,6-7,12-17H2,1H3,(H,25,28) SIIDHHZTVIEQJK-UHFFFAOYSA-N 50119377 Benzofuran-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide::CHEMBL124444::N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)benzofuran-2-carboxamide Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 54 ChEMBL 10.1021/jm0211220 10.7270/Q2H132RF 12930145 Campiani, G; Butini, S; Trotta, F; Fattorusso, C; Catalanotti, B; Aiello, F; Gemma, S; Nacci, V; Novellino, E; Stark, JA; Cagnotto, A; Fumagalli, E; Carnovali, F; Cervo, L; Mennini, T Universit£ di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50119377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50119377&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10092819 104012595 CHEMBL124444 ZINC03817190 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50813774 Clc1ccc(N2CCN(CCCCNC(=O)c3cc4ccccc4[nH]3)CC2)c(Cl)c1 InChI=1S/C23H26Cl2N4O/c24-18-7-8-22(19(25)16-18)29-13-11-28(12-14-29)10-4-3-9-26-23(30)21-15-17-5-1-2-6-20(17)27-21/h1-2,5-8,15-16,27H,3-4,9-14H2,(H,26,30) CYNHGJORJGHXEX-UHFFFAOYSA-N 50131925 1H-Indole-2-carboxylic acid {4-[4-(2,4-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide::CHEMBL339960::N-(4-(4-(2,4-dichlorophenyl)piperazin-1-yl)butyl)-1H-indole-2-carboxamide Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 ChEMBL 10.1021/jm0211220 10.7270/Q2H132RF 12930145 Campiani, G; Butini, S; Trotta, F; Fattorusso, C; Catalanotti, B; Aiello, F; Gemma, S; Nacci, V; Novellino, E; Stark, JA; Cagnotto, A; Fumagalli, E; Carnovali, F; Cervo, L; Mennini, T Universit£ di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131925&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10411237 104022950 CHEMBL339960 ZINC03817191 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50813776 Clc1ccc(N2CCN(CCCCNC(=O)c3cc4cc(Cl)ccc4[nH]3)CC2)c(Cl)c1 InChI=1S/C23H25Cl3N4O/c24-17-3-5-20-16(13-17)14-21(28-20)23(31)27-7-1-2-8-29-9-11-30(12-10-29)22-6-4-18(25)15-19(22)26/h3-6,13-15,28H,1-2,7-12H2,(H,27,31) VGPQHQDBSBJSAG-UHFFFAOYSA-N 50131930 5-Chloro-1H-indole-2-carboxylic acid {4-[4-(2,4-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide::5-chloro-N-(4-(4-(2,4-dichlorophenyl)piperazin-1-yl)butyl)-1H-indole-2-carboxamide::CHEMBL126889 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 ChEMBL 10.1021/jm0211220 10.7270/Q2H132RF 12930145 Campiani, G; Butini, S; Trotta, F; Fattorusso, C; Catalanotti, B; Aiello, F; Gemma, S; Nacci, V; Novellino, E; Stark, JA; Cagnotto, A; Fumagalli, E; Carnovali, F; Cervo, L; Mennini, T Universit£ di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131930&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10367857 104022955 CHEMBL126889 ZINC13525845 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50813782 Clc1ccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c(Cl)c1 InChI=1S/C23H25Cl2N3O2/c24-18-7-8-20(19(25)16-18)28-13-11-27(12-14-28)10-4-3-9-26-23(29)22-15-17-5-1-2-6-21(17)30-22/h1-2,5-8,15-16H,3-4,9-14H2,(H,26,29) GWZLKJUHKRQBRB-UHFFFAOYSA-N 50131923 Benzofuran-2-carboxylic acid {4-[4-(2,4-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide::CHEMBL435218 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 1887 ChEMBL 10.1021/jm0211220 10.7270/Q2H132RF 12930145 Campiani, G; Butini, S; Trotta, F; Fattorusso, C; Catalanotti, B; Aiello, F; Gemma, S; Nacci, V; Novellino, E; Stark, JA; Cagnotto, A; Fumagalli, E; Carnovali, F; Cervo, L; Mennini, T Universit£ di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131923&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10873978 104022948 CHEMBL435218 ZINC13525841 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50813785 COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3c2)CC1 InChI=1S/C26H31N3O2/c1-31-25-11-5-4-10-24(25)29-18-16-28(17-19-29)15-7-6-14-27-26(30)23-13-12-21-8-2-3-9-22(21)20-23/h2-5,8-13,20H,6-7,14-19H2,1H3,(H,27,30) MNHDKMDLOJSCGN-UHFFFAOYSA-N 50119380 CHEMBL25236::CHEMBL540612::N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide::Naphthalene-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 83 ChEMBL 10.1021/jm0211220 10.7270/Q2H132RF 12930145 Campiani, G; Butini, S; Trotta, F; Fattorusso, C; Catalanotti, B; Aiello, F; Gemma, S; Nacci, V; Novellino, E; Stark, JA; Cagnotto, A; Fumagalli, E; Carnovali, F; Cervo, L; Mennini, T Universit£ di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50119380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50119380&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 3038495 104012598 CHEMBL25236CHEMBL540612 ZINC03917109 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50813789 COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1 InChI=1S/C25H30N4O2/c1-31-24-11-5-4-10-23(24)29-16-14-28(15-17-29)13-7-6-12-26-25(30)22-18-20-8-2-3-9-21(20)19-27-22/h2-5,8-11,18-19H,6-7,12-17H2,1H3,(H,26,30) INDXRHKLECFZHX-UHFFFAOYSA-N 50131926 CHEMBL127400::CHEMBL129022::Isoquinoline-3-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 76 ChEMBL 10.1021/jm0211220 10.7270/Q2H132RF 12930145 Campiani, G; Butini, S; Trotta, F; Fattorusso, C; Catalanotti, B; Aiello, F; Gemma, S; Nacci, V; Novellino, E; Stark, JA; Cagnotto, A; Fumagalli, E; Carnovali, F; Cervo, L; Mennini, T Universit£ di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131926&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10895039 104022951 CHEMBL129022CHEMBL127400 ZINC13525815 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50813798 COc1ccccc1N1CCN(CCCCN2CCn3c(cc4ccccc34)C2=O)CC1 InChI=1S/C26H32N4O2/c1-32-25-11-5-4-10-23(25)28-16-14-27(15-17-28)12-6-7-13-29-18-19-30-22-9-3-2-8-21(22)20-24(30)26(29)31/h2-5,8-11,20H,6-7,12-19H2,1H3 BUVJSGDYMDZIDN-UHFFFAOYSA-N 50131920 2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one::CHEMBL420510 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 89 ChEMBL 10.1021/jm0211220 10.7270/Q2H132RF 12930145 Campiani, G; Butini, S; Trotta, F; Fattorusso, C; Catalanotti, B; Aiello, F; Gemma, S; Nacci, V; Novellino, E; Stark, JA; Cagnotto, A; Fumagalli, E; Carnovali, F; Cervo, L; Mennini, T Universit£ di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131920&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 11732785 104022945 CHEMBL420510 ZINC12356444 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50813837 COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1 InChI=1S/C24H30N4O2/c1-30-23-11-5-4-10-22(23)28-16-14-27(15-17-28)13-7-6-12-25-24(29)21-18-19-8-2-3-9-20(19)26-21/h2-5,8-11,18,26H,6-7,12-17H2,1H3,(H,25,29) IRVKXZUMTITJIC-UHFFFAOYSA-N 50131922 1H-Indole-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide::CHEMBL125916::N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-1H-indole-2-carboxamide Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 76 ChEMBL 10.1021/jm0211220 10.7270/Q2H132RF 12930145 Campiani, G; Butini, S; Trotta, F; Fattorusso, C; Catalanotti, B; Aiello, F; Gemma, S; Nacci, V; Novellino, E; Stark, JA; Cagnotto, A; Fumagalli, E; Carnovali, F; Cervo, L; Mennini, T Universit£ di Siena http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50131922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50131922&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 10454026 104022947 CHEMBL125916 ZINC12356361 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50833929 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 50013515 (+)-yohimbine::(16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester::17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester::CHEMBL15245::CORYNANTHINE::Johimbin::Quebrachin::RAUWOLSCINE::YOHIMBINE CHLORIDE::Yohimbin::Yohimbine::aphrodine::cid_8969::corynine::methyl 17alpha-hydroxyyohimban-16alpha-carboxylate::quebrachine::yohimbic acid methyl ester Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 95 ChEMBL 10.1021/jm058018d 10.7270/Q28C9X1X 16250647 Minetti, P; Tinti, MO; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Piersanti, G; Bartoccini, F; Tarzia, G Universit£ degli Studi di Urbino Carlo Bo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50013515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50013515&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 8969 103925641 48565 CHEMBL15245 DB01392 102 C09256 ZINC03860825 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50903433 Fc1ccc2c(c1)nc(N1CCN(Cc3cnc[nH]3)CC1)c1cccn21 InChI=1S/C19H19FN6/c20-14-3-4-17-16(10-14)23-19(18-2-1-5-26(17)18)25-8-6-24(7-9-25)12-15-11-21-13-22-15/h1-5,10-11,13H,6-9,12H2,(H,21,22) BRNJLENJYHXKEL-UHFFFAOYSA-N 50299660 7-fluoro-4-(4-((3H-imidazol-4-yl)methyl)piperazin-1-yl)-pyrrolo[1,2-a]quinoxaline::CHEMBL566522 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 ChEMBL 10.1021/jm901126m 10.7270/Q2H9963M 19831400 Butini, S; Budriesi, R; Hamon, M; Morelli, E; Gemma, S; Brindisi, M; Borrelli, G; Novellino, E; Fiorini, I; Ioan, P; Chiarini, A; Cagnotto, A; Mennini, T; Fracasso, C; Caccia, S; Campiani, G European Research Centre for Drug Discovery and Development (NatSynDrugs) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299660&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 44541937 104141189 CHEMBL566522 ZINC45245703 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50903437 Cc1cccc2nc(N3CCN(Cc4cnc[nH]4)CC3)c3cccn3c12 InChI=1S/C20H22N6/c1-15-4-2-5-17-19(15)26-7-3-6-18(26)20(23-17)25-10-8-24(9-11-25)13-16-12-21-14-22-16/h2-7,12,14H,8-11,13H2,1H3,(H,21,22) UXCYHZPVNXGIRJ-UHFFFAOYSA-N 50299661 9-methyl-4-(4-((3H-imidazol-4-yl)methyl)piperazin-1-yl)-pyrrolo[1,2-a]quinoxaline::CHEMBL582992 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 ChEMBL 10.1021/jm901126m 10.7270/Q2H9963M 19831400 Butini, S; Budriesi, R; Hamon, M; Morelli, E; Gemma, S; Brindisi, M; Borrelli, G; Novellino, E; Fiorini, I; Ioan, P; Chiarini, A; Cagnotto, A; Mennini, T; Fracasso, C; Caccia, S; Campiani, G European Research Centre for Drug Discovery and Development (NatSynDrugs) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299661&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 44541941 104141190 CHEMBL582992 ZINC45319362 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50903442 Fc1ccc2c(c1)nc(N1CCN(Cc3ncc[nH]3)CC1)c1cccn21 InChI=1S/C19H19FN6/c20-14-3-4-16-15(12-14)23-19(17-2-1-7-26(16)17)25-10-8-24(9-11-25)13-18-21-5-6-22-18/h1-7,12H,8-11,13H2,(H,21,22) GLAKGIIOQOOKAC-UHFFFAOYSA-N 50299662 7-fluoro-4-(4-((1H-imidazol-2-yl)methyl)piperazin-1-yl)-pyrrolo[1,2-a]quinoxaline::CHEMBL571046 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 ChEMBL 10.1021/jm901126m 10.7270/Q2H9963M 19831400 Butini, S; Budriesi, R; Hamon, M; Morelli, E; Gemma, S; Brindisi, M; Borrelli, G; Novellino, E; Fiorini, I; Ioan, P; Chiarini, A; Cagnotto, A; Mennini, T; Fracasso, C; Caccia, S; Campiani, G European Research Centre for Drug Discovery and Development (NatSynDrugs) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299662&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 44542076 104141191 CHEMBL571046 ZINC45261462 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 51052511 Oc1ccc(cc1)N1CCN(Cc2cnn(c2)-c2ccc(Cl)cc2)CC1 InChI=1S/C20H21ClN4O/c21-17-1-3-19(4-2-17)25-15-16(13-22-25)14-23-9-11-24(12-10-23)18-5-7-20(26)8-6-18/h1-8,13,15,26H,9-12,14H2 HBGSAORKQHKGPY-UHFFFAOYSA-N 50429260 CHEMBL2333732 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 6450 ChEMBL 10.1016/j.ejmech.2012.08.011 10.7270/Q2QZ2CBK 23353740 Gomes, TF; Pompeu, TE; Rodrigues, DA; Noel, F; Menegatti, R; Andrade, CH; Sabino, JR; Gil, ES; Dalla Costa, T; Betti, AH; Antonio, CB; Rates, SM; Fraga, CA; Barreiro, EJ; de Oliveira, V Universidade Federal de Goi£s http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429260&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 71652196 164158135 CHEMBL2333732 ZINC95592057 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 51052518 Clc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)cn1 InChI=1S/C20H21ClN4/c21-18-6-8-20(9-7-18)25-16-17(14-22-25)15-23-10-12-24(13-11-23)19-4-2-1-3-5-19/h1-9,14,16H,10-13,15H2 MHJWMIITIMUUKU-UHFFFAOYSA-N 50308002 1-[(1-(4-Chlorophenyl)-1H-pyrazol-4-yl)methyl]-4-phenylpiperazine::CHEMBL597601 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 2490 ChEMBL 10.1016/j.ejmech.2012.08.011 10.7270/Q2QZ2CBK 23353740 Gomes, TF; Pompeu, TE; Rodrigues, DA; Noel, F; Menegatti, R; Andrade, CH; Sabino, JR; Gil, ES; Dalla Costa, T; Betti, AH; Antonio, CB; Rates, SM; Fraga, CA; Barreiro, EJ; de Oliveira, V Universidade Federal de Goi£s http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308002&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 11624518 104162363 CHEMBL597601 ZINC53184753 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 51052525 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 QZUDBNBUXVUHMW-UHFFFAOYSA-N 50001884 2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone::3-Hydroxy-2-phenyl-propionic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester::3-chloro-6-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine::8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine (Clozapine)::8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine( Clozepine )::8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Ciozapine)::8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Clopazine)::8-chloro-11-(4-methyl-piperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine::8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine::CHEMBL42::CHEMBL538973::CLOZAPINE::CLOZAPINE, 8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE::CLOZARIL::HF 1854::US10167256, Clozapine::US10752588, Compound Clozapine::US11498896, Compound Clozapine Alpha-2A adrenergic receptor [16-465] Rattus norvegicus 100 ChEMBL 10.1016/j.ejmech.2012.08.011 10.7270/Q2QZ2CBK 23353740 Gomes, TF; Pompeu, TE; Rodrigues, DA; Noel, F; Menegatti, R; Andrade, CH; Sabino, JR; Gil, ES; Dalla Costa, T; Betti, AH; Antonio, CB; Rates, SM; Fraga, CA; Barreiro, EJ; de Oliveira, V Universidade Federal de Goi£s http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001884&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 2818 103916251 3766 CHEMBL42CHEMBL538973 DB00363 38 C06924 ZINC19796155 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3 50068059 Cc1nccn1C[C@H]1CCc2c(C1=O)c1cccc3CCCn2c13 InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,1H3/t15-/m1/s1 NCNFDKWULDWJDS-OAHLLOKOSA-N 50231569 Cilansetron::KC-9946 Alpha-2A adrenergic receptor [16-465] Rattus norvegicus >10000 ChEMBL 10.1021/jm00075a026 10.7270/Q2NS0SZH 8246239 van Wijngaarden, I; Hamminga, D; van Hes, R; Standaar, PJ; Tipker, J; Tulp, MT; Mol, F; Olivier, B; de Jonge, A Solvay Duphar B.V. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50231569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1513&target=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50231569&enzyme=Alpha-2A+adrenergic+receptor+%5B16-465%5D&column=ki&startPg=0&Increment=50&submit=Search 6918107 381616955 1 MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV Alpha-2A adrenergic receptor ADA2A_RAT P22909 M0R9R3