BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 1364858 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(C#N)c(c1)C1CC1)c1ccncc21 InChI=1S/C30H32N6O2/c31-17-23-4-3-20(15-26(23)21-5-6-21)18-33-10-1-2-13-38-14-12-35-30-25-9-11-34-19-27(25)24-8-7-22(29(32)37)16-28(24)36-30/h3-4,7-9,11,15-16,19,21,33H,1-2,5-6,10,12-14,18H2,(H2,32,37)(H,35,36) XTRYJNHCUFWVJN-UHFFFAOYSA-N 644466 5-((2-(4-((4-cyano-3- cyclopropylbenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 60 Casein kinase II subunit alpha [2-329] 2.54 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644466&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915238 490946798 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364860 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1ccc(C3CC3)c(c1)C#N)c1ccncc21 InChI=1S/C30H31N5O3/c31-17-23-15-20(3-7-24(23)21-4-5-21)18-33-10-1-2-12-37-13-14-38-30-26-9-11-34-19-27(26)25-8-6-22(29(32)36)16-28(25)35-30/h3,6-9,11,15-16,19,21,33H,1-2,4-5,10,12-14,18H2,(H2,32,36) CKDCFGNOHLPEKW-UHFFFAOYSA-N 644457 5-(2-(4-((3- cyano-4- cyclopropyl benzyl)amino) butoxy)ethoxy) benzo [c][2,6]naph- thyridine-8- carboxamide::US11866436, Example 51 Casein kinase II subunit alpha [2-329] 0.855 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644457&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914998 490946789 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364862 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OCC(F)(F)F)c(CO)c1)c1ccncc21 InChI=1S/C29H32F3N5O4/c30-29(31,32)18-41-26-6-3-19(13-21(26)17-38)15-34-8-1-2-11-40-12-10-36-28-23-7-9-35-16-24(23)22-5-4-20(27(33)39)14-25(22)37-28/h3-7,9,13-14,16,34,38H,1-2,8,10-12,15,17-18H2,(H2,33,39)(H,36,37) FTEHAPKYBJPKCZ-UHFFFAOYSA-N 644467 5-((2-(4-((3- (hydroxymethyl)- 4-(2,2,2- trifluoroethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 62 Casein kinase II subunit alpha [2-329] 4.48 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644467&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915204 490946799 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364864 CC(C)Oc1ccc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)cc1CO InChI=1S/C30H37N5O4/c1-20(2)39-28-8-5-21(15-23(28)19-36)17-32-10-3-4-13-38-14-12-34-30-25-9-11-33-18-26(25)24-7-6-22(29(31)37)16-27(24)35-30/h5-9,11,15-16,18,20,32,36H,3-4,10,12-14,17,19H2,1-2H3,(H2,31,37)(H,34,35) IGKHUZLMBPNAPW-UHFFFAOYSA-N 644468 5-((2-(4-((3- (hydroxymethyl)-4- isopropoxybenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 63 Casein kinase II subunit alpha [2-329] 4.83 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644468&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914977 490946800 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364866 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC3CCCC3)c(CO)c1)c1ccncc21 InChI=1S/C32H39N5O4/c33-31(39)23-8-9-26-28-20-35-13-11-27(28)32(37-29(26)18-23)36-14-16-40-15-4-3-12-34-19-22-7-10-30(24(17-22)21-38)41-25-5-1-2-6-25/h7-11,13,17-18,20,25,34,38H,1-6,12,14-16,19,21H2,(H2,33,39)(H,36,37) SLOKDUKZOURQFG-UHFFFAOYSA-N 644469 5-((2-(4-((4- (cyclopentyloxy)- 3-(hydroxymethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 64 Casein kinase II subunit alpha [2-329] 0.587 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644469&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915215 490946801 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364868 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(Cl)c(CC#N)c1)c1ccncc21 InChI=1S/C28H29ClN6O2/c29-25-6-3-19(15-20(25)7-9-30)17-32-10-1-2-13-37-14-12-34-28-23-8-11-33-18-24(23)22-5-4-21(27(31)36)16-26(22)35-28/h3-6,8,11,15-16,18,32H,1-2,7,10,12-14,17H2,(H2,31,36)(H,34,35) RSXNAOYYABIBBH-UHFFFAOYSA-N 644470 5-((2-(4-((4- chloro-3- (cyanomethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 65 Casein kinase II subunit alpha [2-329] 4.93 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644470&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915104 490946802 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364870 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cccc(CC#N)c1Cl)c1ccncc21 InChI=1S/C28H29ClN6O2/c29-26-19(8-10-30)4-3-5-21(26)17-32-11-1-2-14-37-15-13-34-28-23-9-12-33-18-24(23)22-7-6-20(27(31)36)16-25(22)35-28/h3-7,9,12,16,18,32H,1-2,8,11,13-15,17H2,(H2,31,36)(H,34,35) GYXOBURXCQKQPD-UHFFFAOYSA-N 644471 5-((2-(4-((2-chloro- 3-(cyanomethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 66 Casein kinase II subunit alpha [2-329] 5.75 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644471&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915213 490946803 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364872 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cccc(CO)c1Cl)c1ccncc21 InChI=1S/C27H30ClN5O3/c28-25-19(4-3-5-20(25)17-34)15-30-9-1-2-12-36-13-11-32-27-22-8-10-31-16-23(22)21-7-6-18(26(29)35)14-24(21)33-27/h3-8,10,14,16,30,34H,1-2,9,11-13,15,17H2,(H2,29,35)(H,32,33) HYKFPSGYKWSUHL-UHFFFAOYSA-N 644472 5-((2-(4-((2- chloro-3- (hydroxymethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 67 Casein kinase II subunit alpha [2-329] 11.8 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644472&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915146 490946804 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364874 CCOc1ccc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)cc1CO InChI=1S/C29H35N5O4/c1-2-38-27-8-5-20(15-22(27)19-35)17-31-10-3-4-13-37-14-12-33-29-24-9-11-32-18-25(24)23-7-6-21(28(30)36)16-26(23)34-29/h5-9,11,15-16,18,31,35H,2-4,10,12-14,17,19H2,1H3,(H2,30,36)(H,33,34) NMRYIKICBOHGSO-UHFFFAOYSA-N 644473 5-((2-(4- ((4-ethoxy-3- (hydroxymethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 68 Casein kinase II subunit alpha [2-329] 27.5 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644473&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915191 490946805 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364876 OCc1cc(F)cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(O)=O)c1 InChI=1S/C27H29FN4O4/c28-21-12-18(11-19(13-21)17-33)15-29-6-1-2-9-36-10-8-31-26-23-5-7-30-16-24(23)22-4-3-20(27(34)35)14-25(22)32-26/h3-5,7,11-14,16,29,33H,1-2,6,8-10,15,17H2,(H,31,32)(H,34,35) YJMYXQDIARLBTI-UHFFFAOYSA-N 644474 5-((2-(4-((3-Fluoro-5-(hydroxymethyl)benzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 69 Casein kinase II subunit alpha [2-329] 0.633 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644474&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915224 490946806 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364878 OCc1cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(O)=O)cc(c1)C(F)(F)F InChI=1S/C28H29F3N4O4/c29-28(30,31)21-12-18(11-19(13-21)17-36)15-32-6-1-2-9-39-10-8-34-26-23-5-7-33-16-24(23)22-4-3-20(27(37)38)14-25(22)35-26/h3-5,7,11-14,16,32,36H,1-2,6,8-10,15,17H2,(H,34,35)(H,37,38) GHOJVOKLPQVRCC-UHFFFAOYSA-N 644475 5-((2-(4-((3- (hydroxy- methyl)-5- (trifluoro- methyl) benzyl)amino) butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 70 Casein kinase II subunit alpha [2-329] 0.517 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644475&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915032 490946807 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364880 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(F)cc(CC#N)c1)c1ccncc21 InChI=1S/C28H28FN5O3/c29-22-14-19(5-7-30)13-20(15-22)17-31-8-1-2-11-37-12-10-33-27-24-6-9-32-18-25(24)23-4-3-21(28(35)36)16-26(23)34-27/h3-4,6,9,13-16,18,31H,1-2,5,8,10-12,17H2,(H,33,34)(H,35,36) GGHCFHXCBYOKTF-UHFFFAOYSA-N 644476 5-((2-(4-((3- (cyanomethyl)- 5- fluorobenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 71 Casein kinase II subunit alpha [2-329] 0.691 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644476&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915045 490946808 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364882 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CC#N)cc(c1)C(F)(F)F)c1ccncc21 InChI=1S/C29H28F3N5O3/c30-29(31,32)22-14-19(5-7-33)13-20(15-22)17-34-8-1-2-11-40-12-10-36-27-24-6-9-35-18-25(24)23-4-3-21(28(38)39)16-26(23)37-27/h3-4,6,9,13-16,18,34H,1-2,5,8,10-12,17H2,(H,36,37)(H,38,39) BCNGHEQNBDRXPI-UHFFFAOYSA-N 644477 5-((2-(4-((3- (cyanomethyl)- 5- (trifluoro- methyl) benzyl) amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 72 Casein kinase II subunit alpha [2-329] 0.655 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644477&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915230 490946809 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364884 Cc1cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(O)=O)cc(CC#N)c1 InChI=1S/C29H31N5O3/c1-20-14-21(6-8-30)16-22(15-20)18-31-9-2-3-12-37-13-11-33-28-25-7-10-32-19-26(25)24-5-4-23(29(35)36)17-27(24)34-28/h4-5,7,10,14-17,19,31H,2-3,6,9,11-13,18H2,1H3,(H,33,34)(H,35,36) CUENLDJTQKFFPA-UHFFFAOYSA-N 644478 5-((2-(4-((3- (cyanomethyl)- 5- methyl- benzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8- carboxylic acid::US11866436, Example 73 Casein kinase II subunit alpha [2-329] 0.713 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644478&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915234 490946810 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364886 OCc1cc(F)cc(CNCCCCOCCOc2nc3cc(ccc3c3cnccc23)C(O)=O)c1 InChI=1S/C27H28FN3O5/c28-21-12-18(11-19(13-21)17-32)15-29-6-1-2-8-35-9-10-36-26-23-5-7-30-16-24(23)22-4-3-20(27(33)34)14-25(22)31-26/h3-5,7,11-14,16,29,32H,1-2,6,8-10,15,17H2,(H,33,34) OXUHZNGGQZYPHE-UHFFFAOYSA-N 644479 5-(2-(4-((3- fluoro-5- (hydroxymethyl) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 74 Casein kinase II subunit alpha [2-329] 0.787 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644479&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915221 490946811 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364888 OCc1cc(CNCCCCOCCOc2nc3cc(ccc3c3cnccc23)C(O)=O)cc(c1)C(F)(F)F InChI=1S/C28H28F3N3O5/c29-28(30,31)21-12-18(11-19(13-21)17-35)15-32-6-1-2-8-38-9-10-39-26-23-5-7-33-16-24(23)22-4-3-20(27(36)37)14-25(22)34-26/h3-5,7,11-14,16,32,35H,1-2,6,8-10,15,17H2,(H,36,37) JPMMONIVZGUBLU-UHFFFAOYSA-N 644480 5-(2-(4-((3- (hydroxy- methyl)-5- (trifluoromethyl) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 75 Casein kinase II subunit alpha [2-329] 0.773 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644480&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915138 490946812 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364890 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(Cl)cc(CC#N)c1)c1ccncc21 InChI=1S/C28H27ClN4O4/c29-22-14-19(5-7-30)13-20(15-22)17-31-8-1-2-10-36-11-12-37-27-24-6-9-32-18-25(24)23-4-3-21(28(34)35)16-26(23)33-27/h3-4,6,9,13-16,18,31H,1-2,5,8,10-12,17H2,(H,34,35) IINWRBNZDZJCAH-UHFFFAOYSA-N 644481 5-(2-(4-((3- chloro-5- (cyanomethyl) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 76 Casein kinase II subunit alpha [2-329] 0.778 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644481&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915184 490946813 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364892 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(CC#N)cc(c1)C(F)(F)F)c1ccncc21 InChI=1S/C29H27F3N4O4/c30-29(31,32)22-14-19(5-7-33)13-20(15-22)17-34-8-1-2-10-39-11-12-40-27-24-6-9-35-18-25(24)23-4-3-21(28(37)38)16-26(23)36-27/h3-4,6,9,13-16,18,34H,1-2,5,8,10-12,17H2,(H,37,38) WHKVBWGIZNCFIH-UHFFFAOYSA-N 644482 5-(2-(4-((3- (cyanomethyl)- 5- (trifluoromethyl) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 77 Casein kinase II subunit alpha [2-329] 0.670 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644482&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915297 490946814 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364894 Cc1cc(CNCCCCOCCOc2nc3cc(ccc3c3cnccc23)C(O)=O)cc(CC#N)c1 InChI=1S/C29H30N4O4/c1-20-14-21(6-8-30)16-22(15-20)18-31-9-2-3-11-36-12-13-37-28-25-7-10-32-19-26(25)24-5-4-23(29(34)35)17-27(24)33-28/h4-5,7,10,14-17,19,31H,2-3,6,9,11-13,18H2,1H3,(H,34,35) MWGBCUIRQLARSR-UHFFFAOYSA-N 644483 5-(2-(4-((3- (cyanomethyl)- 5- methylbenzyl) amino)butoxy) ethoxy)benzo [c][2,6]naph- thyridine-8- carboxylic acid::US11866436, Example 78 Casein kinase II subunit alpha [2-329] 0.725 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644483&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915192 490946815 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364896 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(F)cc(CC#N)c1)c1ccncc21 InChI=1S/C29H28FN5O3/c30-22-12-19(5-7-31)11-20(13-22)15-32-8-1-2-10-38-23-17-35(18-23)28-25-6-9-33-16-26(25)24-4-3-21(29(36)37)14-27(24)34-28/h3-4,6,9,11-14,16,23,32H,1-2,5,8,10,15,17-18H2,(H,36,37) DPYBFMFLTZVAGA-UHFFFAOYSA-N 644484 5-(3-(4-((3-(Cyanomethyl)-5-fluorobenzyl)amino)butoxy)azetidin-1-yl)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 79 Casein kinase II subunit alpha [2-329] 1.44 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644484&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915079 490946816 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364898 Cc1cc(CNCCCCOC2CN(C2)c2nc3cc(ccc3c3cnccc23)C(O)=O)cc(CC#N)c1 InChI=1S/C30H31N5O3/c1-20-12-21(6-8-31)14-22(13-20)16-32-9-2-3-11-38-24-18-35(19-24)29-26-7-10-33-17-27(26)25-5-4-23(30(36)37)15-28(25)34-29/h4-5,7,10,12-15,17,24,32H,2-3,6,9,11,16,18-19H2,1H3,(H,36,37) KVCPSOPLIQVJAJ-UHFFFAOYSA-N 644485 5-(3-(4-((3- (cyanomethyl)- 5- methylbenzyl) amino)butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 80 Casein kinase II subunit alpha [2-329] 1.67 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644485&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915248 490946817 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364900 OCc1cc(Cl)cc(CNCCCCOC2CN(C2)c2nc3cc(ccc3c3cnccc23)C(O)=O)c1 InChI=1S/C28H29ClN4O4/c29-21-10-18(9-19(11-21)17-34)13-30-6-1-2-8-37-22-15-33(16-22)27-24-5-7-31-14-25(24)23-4-3-20(28(35)36)12-26(23)32-27/h3-5,7,9-12,14,22,30,34H,1-2,6,8,13,15-17H2,(H,35,36) MZQCXULGGNKLHX-UHFFFAOYSA-N 644486 5-(3-(4-((3- chloro-5- (hydroxy- methyl) benzyl)amino) butoxy) azetidin-1- yl)benzo[c] [2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 81 Casein kinase II subunit alpha [2-329] 1.38 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644486&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915124 490946818 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364902 OCc1cc(F)cc(CNCCCCOC2CN(C2)c2nc3cc(ccc3c3cnccc23)C(O)=O)c1 InChI=1S/C28H29FN4O4/c29-21-10-18(9-19(11-21)17-34)13-30-6-1-2-8-37-22-15-33(16-22)27-24-5-7-31-14-25(24)23-4-3-20(28(35)36)12-26(23)32-27/h3-5,7,9-12,14,22,30,34H,1-2,6,8,13,15-17H2,(H,35,36) RMQZLMLMRYHGDT-UHFFFAOYSA-N 644487 5-(3-(4-((3- fluoro-5- (hydroxy- methyl) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 82 Casein kinase II subunit alpha [2-329] 2.11 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644487&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915042 490946819 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364904 NC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1ccc(OC(F)(F)F)c(F)c1)c1ccncc21 InChI=1S/C28H27F4N5O3/c29-23-11-17(3-6-25(23)40-28(30,31)32)13-34-8-1-2-10-39-19-15-37(16-19)27-21-7-9-35-14-22(21)20-5-4-18(26(33)38)12-24(20)36-27/h3-7,9,11-12,14,19,34H,1-2,8,10,13,15-16H2,(H2,33,38) YVLMVVBOFKFZII-UHFFFAOYSA-N 644488 US11866436, Example 83 Casein kinase II subunit alpha [2-329] 11.8 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644488&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915089 490946820 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364906 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CO)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C28H30F3N5O4/c29-28(30,31)40-21-12-18(11-19(13-21)17-37)15-33-6-1-2-9-39-10-8-35-27-23-5-7-34-16-24(23)22-4-3-20(26(32)38)14-25(22)36-27/h3-5,7,11-14,16,33,37H,1-2,6,8-10,15,17H2,(H2,32,38)(H,35,36) LYFVRXSZWCBPKX-UHFFFAOYSA-N 644489 5-((2-(4-((3- (hydroxymethyl)- 5-(trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 84 Casein kinase II subunit alpha [2-329] 0.612 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644489&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915150 490946821 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364908 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(c(CO)c1)C(F)(F)F)c1ccncc21 InChI=1S/C28H30F3N5O3/c29-28(30,31)24-6-3-18(13-20(24)17-37)15-33-8-1-2-11-39-12-10-35-27-22-7-9-34-16-23(22)21-5-4-19(26(32)38)14-25(21)36-27/h3-7,9,13-14,16,33,37H,1-2,8,10-12,15,17H2,(H2,32,38)(H,35,36) TZIIUQQIFMFTRP-UHFFFAOYSA-N 644490 5-((2-(4-((3- (hydroxymethyl)- 4-(trifluoromethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 85 Casein kinase II subunit alpha [2-329] 4.83 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644490&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915199 490946822 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364910 C[C@@H](COCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)Nc1nc2cc(ccc2c2cnccc12)C(O)=O InChI=1S/C28H28ClF3N4O4/c1-17(16-39-11-3-2-9-33-14-18-4-7-25(23(29)12-18)40-28(30,31)32)35-26-21-8-10-34-15-22(21)20-6-5-19(27(37)38)13-24(20)36-26/h4-8,10,12-13,15,17,33H,2-3,9,11,14,16H2,1H3,(H,35,36)(H,37,38)/t17-/m0/s1 JOQWRLVZVPMTGG-KRWDZBQOSA-N 644491 (S)-5-((1-(4-((3-Chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)propan-2-yl)amino)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 86 Casein kinase II subunit alpha [2-329] 0.361 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644491&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915155 490946823 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364912 COc1cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)cc(CC#N)c1 InChI=1S/C29H32N6O3/c1-37-23-15-20(6-8-30)14-21(16-23)18-32-9-2-3-12-38-13-11-34-29-25-7-10-33-19-26(25)24-5-4-22(28(31)36)17-27(24)35-29/h4-5,7,10,14-17,19,32H,2-3,6,9,11-13,18H2,1H3,(H2,31,36)(H,34,35) HNQZVIUHQVBZNE-UHFFFAOYSA-N 644492 5-((2-(4-((3- (cyanomethyl)- 5-methoxybenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 87 Casein kinase II subunit alpha [2-329] 2.50 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644492&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915027 490946824 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364914 C[C@H](COCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)Nc1nc2cc(ccc2c2cnccc12)C(O)=O InChI=1S/C28H28ClF3N4O4/c1-17(16-39-11-3-2-9-33-14-18-4-7-25(23(29)12-18)40-28(30,31)32)35-26-21-8-10-34-15-22(21)20-6-5-19(27(37)38)13-24(20)36-26/h4-8,10,12-13,15,17,33H,2-3,9,11,14,16H2,1H3,(H,35,36)(H,37,38)/t17-/m1/s1 JOQWRLVZVPMTGG-QGZVFWFLSA-N 644493 (R)-5-((1-(4-((3-chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)propan-2-yl)amino)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 88 Casein kinase II subunit alpha [2-329] 0.359 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644493&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915076 490946825 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364916 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CC#N)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C29H29F3N6O3/c30-29(31,32)41-22-14-19(5-7-33)13-20(15-22)17-35-8-1-2-11-40-12-10-37-28-24-6-9-36-18-25(24)23-4-3-21(27(34)39)16-26(23)38-28/h3-4,6,9,13-16,18,35H,1-2,5,8,10-12,17H2,(H2,34,39)(H,37,38) PRJZUMDFBBOMPR-UHFFFAOYSA-N 644494 5-((2-(4-((3- (cyanomethyl)- 5-(trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 89 Casein kinase II subunit alpha [2-329] 0.469 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644494&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915162 490946826 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364918 OCc1cc(Cl)cc(CNCCCCOCCOc2nc3cc(ccc3c3cnccc23)C(O)=O)c1 InChI=1S/C27H28ClN3O5/c28-21-12-18(11-19(13-21)17-32)15-29-6-1-2-8-35-9-10-36-26-23-5-7-30-16-24(23)22-4-3-20(27(33)34)14-25(22)31-26/h3-5,7,11-14,16,29,32H,1-2,6,8-10,15,17H2,(H,33,34) XXNWOAPHJYPEGP-UHFFFAOYSA-N 644495 5-(2-(4-((3- chloro-5- (hydroxymethyl) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 90 Casein kinase II subunit alpha [2-329] 0.573 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644495&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915086 490946827 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364920 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(CO)cc(c1)C(F)(F)F)c1ccncc21 InChI=1S/C28H29F3N4O4/c29-28(30,31)21-12-18(11-19(13-21)17-36)15-33-6-1-2-8-38-9-10-39-27-23-5-7-34-16-24(23)22-4-3-20(26(32)37)14-25(22)35-27/h3-5,7,11-14,16,33,36H,1-2,6,8-10,15,17H2,(H2,32,37) CZBRTHXLKCLQJQ-UHFFFAOYSA-N 644496 5-(2-(4-((3- (hydroxy- methyl)-5- (trifluoro- methyl)benzyl) amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine-8- carboxamide::US11866436, Example 91 Casein kinase II subunit alpha [2-329] 2.07 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644496&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915209 490946828 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364922 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(F)cc(CC#N)c1)c1ccncc21 InChI=1S/C28H28FN5O3/c29-22-14-19(5-7-30)13-20(15-22)17-32-8-1-2-10-36-11-12-37-28-24-6-9-33-18-25(24)23-4-3-21(27(31)35)16-26(23)34-28/h3-4,6,9,13-16,18,32H,1-2,5,8,10-12,17H2,(H2,31,35) YFJHJYHTHWHQSE-UHFFFAOYSA-N 644497 5-(2-(4-((3- (cyanomethyl)- 5- fluorobenzyl) amino)butoxy) ethoxy) benzo[c][2, 6]naphthy- ridine-8- carboxamide::US11866436, Example 92 Casein kinase II subunit alpha [2-329] 1.61 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644497&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915025 490946829 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364924 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1ccc(OC(F)(F)F)c(F)c1)c1ccncc21 InChI=1S/C27H25F4N3O5/c28-22-13-17(3-6-24(22)39-27(29,30)31)15-32-8-1-2-10-37-11-12-38-25-20-7-9-33-16-21(20)19-5-4-18(26(35)36)14-23(19)34-25/h3-7,9,13-14,16,32H,1-2,8,10-12,15H2,(H,35,36) XZMVOPBXTNARPU-UHFFFAOYSA-N 644498 5-(2-(4-((3- fluoro-4- (trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic::US11866436, Example 93 Casein kinase II subunit alpha [2-329] 0.354 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644498&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915133 490946830 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364926 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(F)cc(CO)c1)c1ccncc21 InChI=1S/C27H29FN4O4/c28-21-12-18(11-19(13-21)17-33)15-30-6-1-2-8-35-9-10-36-27-23-5-7-31-16-24(23)22-4-3-20(26(29)34)14-25(22)32-27/h3-5,7,11-14,16,30,33H,1-2,6,8-10,15,17H2,(H2,29,34) YENVFOAOYGSPNI-UHFFFAOYSA-N 644499 5-(2-(4-((3- fluoro-5- (hydroxy- methyl)benzyl) amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine-8- carboxamide::US11866436, Example 94 Casein kinase II subunit alpha [2-329] 7.05 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644499&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915288 490946831 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364928 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(F)cc(CC#N)c1)c1ccncc21 InChI=1S/C28H27FN4O4/c29-22-14-19(5-7-30)13-20(15-22)17-31-8-1-2-10-36-11-12-37-27-24-6-9-32-18-25(24)23-4-3-21(28(34)35)16-26(23)33-27/h3-4,6,9,13-16,18,31H,1-2,5,8,10-12,17H2,(H,34,35) WTHVHUDPRPCKCA-UHFFFAOYSA-N 644500 5-(2-(4-((3- (cyanomethyl)- 5- fluorobenzyl) amino)butoxy) ethoxy)benzo[c] [2,6]naphthy- ridine-8- carboxylic acid::US11866436, Example 95 Casein kinase II subunit alpha [2-329] 0.418 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644500&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915229 490946832 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364930 Cc1cc(CNCCCCOCCOc2nc3cc(ccc3c3cnccc23)C(N)=O)cc(CC#N)c1 InChI=1S/C29H31N5O3/c1-20-14-21(6-8-30)16-22(15-20)18-32-9-2-3-11-36-12-13-37-29-25-7-10-33-19-26(25)24-5-4-23(28(31)35)17-27(24)34-29/h4-5,7,10,14-17,19,32H,2-3,6,9,11-13,18H2,1H3,(H2,31,35) NGWGFXYGZQEEQC-UHFFFAOYSA-N 644501 5-(2-(4-((3- (cyanomethyl)- 5- methylbenzyl) amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine-8- carboxamide::US11866436, Example 96 Casein kinase II subunit alpha [2-329] 2.93 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644501&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915096 490946833 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364932 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(CC#N)cc(c1)C(F)(F)F)c1ccncc21 InChI=1S/C29H28F3N5O3/c30-29(31,32)22-14-19(5-7-33)13-20(15-22)17-35-8-1-2-10-39-11-12-40-28-24-6-9-36-18-25(24)23-4-3-21(27(34)38)16-26(23)37-28/h3-4,6,9,13-16,18,35H,1-2,5,8,10-12,17H2,(H2,34,38) VANUWFIFOADNQT-UHFFFAOYSA-N 644502 5-(2-(4-((3- (cyanomethyl)- 5- (trifluoromethyl) benzyl) amino)butoxy) ethoxy)benzo [c][2,6] naphthyridine- 8- carboxamide::US11866436, Example 97 Casein kinase II subunit alpha [2-329] 1.14 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644502&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915015 490946834 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364934 NC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(CC#N)cc(c1)C(F)(F)F)c1ccncc21 InChI=1S/C30H29F3N6O2/c31-30(32,33)22-12-19(5-7-34)11-20(13-22)15-36-8-1-2-10-41-23-17-39(18-23)29-25-6-9-37-16-26(25)24-4-3-21(28(35)40)14-27(24)38-29/h3-4,6,9,11-14,16,23,36H,1-2,5,8,10,15,17-18H2,(H2,35,40) FTVFEILOOGBUKN-UHFFFAOYSA-N 644503 5-(3-(4-((3- (cyanomethyl)- 5-(trifluoro- methyl) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 98 Casein kinase II subunit alpha [2-329] 22.3 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644503&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915128 490946835 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364936 FC(F)(F)Oc1ccc(CNCCCCOC2CN(C2)c2nc3ccccc3c3cnccc23)cc1Cl InChI=1S/C27H26ClF3N4O2/c28-23-13-18(7-8-25(23)37-27(29,30)31)14-32-10-3-4-12-36-19-16-35(17-19)26-21-9-11-33-15-22(21)20-5-1-2-6-24(20)34-26/h1-2,5-9,11,13,15,19,32H,3-4,10,12,14,16-17H2 ZHELCWGHFGQNAY-UHFFFAOYSA-N 644504 5-(3-(4-((3- chloro-4- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine-::US11866436, Example 99 Casein kinase II subunit alpha [2-329] 14.7 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644504&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 169767853 490946836 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364938 OCc1cc(CNCCCCOC2CN(C2)c2nc3cc(ccc3c3cnccc23)C(O)=O)cc(c1)C(F)(F)F InChI=1S/C29H29F3N4O4/c30-29(31,32)21-10-18(9-19(11-21)17-37)13-33-6-1-2-8-40-22-15-36(16-22)27-24-5-7-34-14-25(24)23-4-3-20(28(38)39)12-26(23)35-27/h3-5,7,9-12,14,22,33,37H,1-2,6,8,13,15-17H2,(H,38,39) CQBXPNGRORFMAH-UHFFFAOYSA-N 644505 5-(3-(4-((3- (hydroxy- methyl)-5- (trifluoro- methyl) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 100 Casein kinase II subunit alpha [2-329] 1.07 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644505&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915153 490946837 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364940 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1ccc(OC(F)(F)F)c(F)c1)c1ccncc21 InChI=1S/C28H26F4N4O4/c29-23-11-17(3-6-25(23)40-28(30,31)32)13-33-8-1-2-10-39-19-15-36(16-19)26-21-7-9-34-14-22(21)20-5-4-18(27(37)38)12-24(20)35-26/h3-7,9,11-12,14,19,33H,1-2,8,10,13,15-16H2,(H,37,38) XQYWZGQSHLDADK-UHFFFAOYSA-N 644506 5-(3-(4-((3- fluoro-4- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine-::US11866436, Example 101 Casein kinase II subunit alpha [2-329] 0.258 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644506&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914978 490946838 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364942 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(Cl)cc(CC#N)c1)c1ccncc21 InChI=1S/C29H28ClN5O3/c30-22-12-19(5-7-31)11-20(13-22)15-32-8-1-2-10-38-23-17-35(18-23)28-25-6-9-33-16-26(25)24-4-3-21(29(36)37)14-27(24)34-28/h3-4,6,9,11-14,16,23,32H,1-2,5,8,10,15,17-18H2,(H,36,37) HLJDNMVEJYCKAW-UHFFFAOYSA-N 644507 5-(3-(4-((3- chloro-5- (cyanomethyl) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 102 Casein kinase II subunit alpha [2-329] 0.324 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644507&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914970 490946839 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364944 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(CC#N)cc(c1)C(F)(F)F)c1ccncc21 InChI=1S/C30H28F3N5O3/c31-30(32,33)22-12-19(5-7-34)11-20(13-22)15-35-8-1-2-10-41-23-17-38(18-23)28-25-6-9-36-16-26(25)24-4-3-21(29(39)40)14-27(24)37-28/h3-4,6,9,11-14,16,23,35H,1-2,5,8,10,15,17-18H2,(H,39,40) OJAHYTKDTIYGRY-UHFFFAOYSA-N 644508 5-(3-(4-((3- (cyanomethyl)- 5-(trifluoro- methyl) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 103 Casein kinase II subunit alpha [2-329] 0.453 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644508&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915140 490946840 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364946 NC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(Cl)cc(CC#N)c1)c1ccncc21 InChI=1S/C29H29ClN6O2/c30-22-12-19(5-7-31)11-20(13-22)15-33-8-1-2-10-38-23-17-36(18-23)29-25-6-9-34-16-26(25)24-4-3-21(28(32)37)14-27(24)35-29/h3-4,6,9,11-14,16,23,33H,1-2,5,8,10,15,17-18H2,(H2,32,37) SSLQYXLLEVVVAB-UHFFFAOYSA-N 644509 5-(3-(4-((3- chloro-5- (cyanomethyl) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8- carboxamide::US11866436, Example 104 Casein kinase II subunit alpha [2-329] 13.3 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644509&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915290 490946841 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364948 CC(C)(C#N)c1cc(Cl)cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)c1 InChI=1S/C30H33ClN6O2/c1-30(2,19-32)22-13-20(14-23(31)16-22)17-34-8-3-4-11-39-12-10-36-29-25-7-9-35-18-26(25)24-6-5-21(28(33)38)15-27(24)37-29/h5-7,9,13-16,18,34H,3-4,8,10-12,17H2,1-2H3,(H2,33,38)(H,36,37) UDOOJICAHXLHPL-UHFFFAOYSA-N 644510 5-((2-(4-((3- chloro-5-(2- cyanopropan- 2-yl)benzyl) amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 105 Casein kinase II subunit alpha [2-329] 0.476 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644510&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915022 490946842 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364950 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(Cl)cc(c1)C1(CC1)C#N)c1ccncc21 InChI=1S/C30H31ClN6O2/c31-23-14-20(13-22(16-23)30(19-32)6-7-30)17-34-8-1-2-11-39-12-10-36-29-25-5-9-35-18-26(25)24-4-3-21(28(33)38)15-27(24)37-29/h3-5,9,13-16,18,34H,1-2,6-8,10-12,17H2,(H2,33,38)(H,36,37) TZGUAAJXHPFHGU-UHFFFAOYSA-N 644511 5-((2-(4-((3- chloro-5- (1-cyano- cyclopropyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 106 Casein kinase II subunit alpha [2-329] 0.263 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644511&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915182 490946843 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364952 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(CC#N)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C29H28F3N5O4/c30-29(31,32)41-22-14-19(5-7-33)13-20(15-22)17-35-8-1-2-10-39-11-12-40-28-24-6-9-36-18-25(24)23-4-3-21(27(34)38)16-26(23)37-28/h3-4,6,9,13-16,18,35H,1-2,5,8,10-12,17H2,(H2,34,38) YIAAJLFYNDAYHN-UHFFFAOYSA-N 644512 5-(2-(4-((3- (cyanomethyl)- 5-(trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 107 Casein kinase II subunit alpha [2-329] 0.437 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644512&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915054 490946844 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364954 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CC#N)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C29H28F3N5O4/c30-29(31,32)41-22-14-19(5-7-33)13-20(15-22)17-34-8-1-2-11-40-12-10-36-27-24-6-9-35-18-25(24)23-4-3-21(28(38)39)16-26(23)37-27/h3-4,6,9,13-16,18,34H,1-2,5,8,10-12,17H2,(H,36,37)(H,38,39) SPXYVKFVIYDTRR-UHFFFAOYSA-N 644513 5-((2-(4-((3- (cyanomethyl)- 5-(trifluoro- methoxy) benzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8- carboxylic acid::US11866436, Example 108 Casein kinase II subunit alpha [2-329] 0.304 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644513&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915214 490946845 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364956 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(CC#N)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C30H28F3N5O4/c31-30(32,33)42-22-12-19(5-7-34)11-20(13-22)15-35-8-1-2-10-41-23-17-38(18-23)28-25-6-9-36-16-26(25)24-4-3-21(29(39)40)14-27(24)37-28/h3-4,6,9,11-14,16,23,35H,1-2,5,8,10,15,17-18H2,(H,39,40) QYPKTKWUCZJBOC-UHFFFAOYSA-N 644514 5-(3-(4-((3- (cyanomethyl)- 5-(trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 109 Casein kinase II subunit alpha [2-329] 0.476 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644514&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915091 490946846 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364958 NC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(CC#N)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C30H29F3N6O3/c31-30(32,33)42-22-12-19(5-7-34)11-20(13-22)15-36-8-1-2-10-41-23-17-39(18-23)29-25-6-9-37-16-26(25)24-4-3-21(28(35)40)14-27(24)38-29/h3-4,6,9,11-14,16,23,36H,1-2,5,8,10,15,17-18H2,(H2,35,40) MRLCKZFWBPSDNL-UHFFFAOYSA-N 644515 5-(3-(4-((3- (cyanomethyl)- 5-(trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8- carboxamide::US11866436, Example 110 Casein kinase II subunit alpha [2-329] 6.21 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644515&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915084 490946847 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364960 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(CC#N)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C29H27F3N4O5/c30-29(31,32)41-22-14-19(5-7-33)13-20(15-22)17-34-8-1-2-10-39-11-12-40-27-24-6-9-35-18-25(24)23-4-3-21(28(37)38)16-26(23)36-27/h3-4,6,9,13-16,18,34H,1-2,5,8,10-12,17H2,(H,37,38) DITIJPXRAGWNLI-UHFFFAOYSA-N 644516 5-(2-(4-((3- (cyanomethyl)- 5-(trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 111 Casein kinase II subunit alpha [2-329] 0.354 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644516&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915188 490946848 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364962 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1ccc(OC(F)(F)F)c(Br)c1)c1ccncc21 InChI=1S/C27H25BrF3N3O5/c28-22-13-17(3-6-24(22)39-27(29,30)31)15-32-8-1-2-10-37-11-12-38-25-20-7-9-33-16-21(20)19-5-4-18(26(35)36)14-23(19)34-25/h3-7,9,13-14,16,32H,1-2,8,10-12,15H2,(H,35,36) ZTXIJZHBTZODLI-UHFFFAOYSA-N 644517 5-(2-(4-((3- bromo-4- (trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 112 Casein kinase II subunit alpha [2-329] 0.411 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644517&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915289 490946849 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364964 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1ccc(Cl)c(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C27H25ClF3N3O5/c28-22-6-3-17(13-24(22)39-27(29,30)31)15-32-8-1-2-10-37-11-12-38-25-20-7-9-33-16-21(20)19-5-4-18(26(35)36)14-23(19)34-25/h3-7,9,13-14,16,32H,1-2,8,10-12,15H2,(H,35,36) ZETRLMBMIJORIT-UHFFFAOYSA-N 644518 5-(2-(4-((4- chloro-3- (trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 113 Casein kinase II subunit alpha [2-329] 0.409 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644518&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915148 490946850 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364966 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(Cl)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C27H25ClF3N3O5/c28-19-11-17(12-20(14-19)39-27(29,30)31)15-32-6-1-2-8-37-9-10-38-25-22-5-7-33-16-23(22)21-4-3-18(26(35)36)13-24(21)34-25/h3-5,7,11-14,16,32H,1-2,6,8-10,15H2,(H,35,36) LXALJHQHXMDTSD-UHFFFAOYSA-N 644519 5-(2-(4-((3- chloro-5- (trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 114 Casein kinase II subunit alpha [2-329] 0.342 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644519&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915110 490946851 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364968 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(Br)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C27H25BrF3N3O5/c28-19-11-17(12-20(14-19)39-27(29,30)31)15-32-6-1-2-8-37-9-10-38-25-22-5-7-33-16-23(22)21-4-3-18(26(35)36)13-24(21)34-25/h3-5,7,11-14,16,32H,1-2,6,8-10,15H2,(H,35,36) XHRUYQISWOKHBR-UHFFFAOYSA-N 644520 5-(2-(4-((3- bromo-5- (trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 115 Casein kinase II subunit alpha [2-329] 0.248 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644520&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915050 490946852 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364970 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(F)c(OC(F)(F)F)c(F)c1)c1ccncc21 InChI=1S/C27H24F5N3O5/c28-21-11-16(12-22(29)24(21)40-27(30,31)32)14-33-6-1-2-8-38-9-10-39-25-19-5-7-34-15-20(19)18-4-3-17(26(36)37)13-23(18)35-25/h3-5,7,11-13,15,33H,1-2,6,8-10,14H2,(H,36,37) VQXFVWAFGKCRFO-UHFFFAOYSA-N 644521 5-(2-(4-((3,5-difluoro-4-(trifluoromethoxy)benzyl)amino)butoxy)ethoxy)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 116 Casein kinase II subunit alpha [2-329] 0.318 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644521&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915063 490946853 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364972 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(OC(F)(F)F)cc(c1)C1CC1)c1ccncc21 InChI=1S/C30H30F3N3O5/c31-30(32,33)41-23-14-19(13-22(15-23)20-3-4-20)17-34-8-1-2-10-39-11-12-40-28-25-7-9-35-18-26(25)24-6-5-21(29(37)38)16-27(24)36-28/h5-7,9,13-16,18,20,34H,1-4,8,10-12,17H2,(H,37,38) QIYSFZUFUMZRFH-UHFFFAOYSA-N 644522 5-(2-(4-((3- cyclopropyl-5- (trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 117 Casein kinase II subunit alpha [2-329] 0.365 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644522&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915151 490946854 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364974 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(F)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C28H26F4N4O4/c29-19-9-17(10-20(12-19)40-28(30,31)32)13-33-6-1-2-8-39-21-15-36(16-21)26-23-5-7-34-14-24(23)22-4-3-18(27(37)38)11-25(22)35-26/h3-5,7,9-12,14,21,33H,1-2,6,8,13,15-16H2,(H,37,38) PYLWPZITQSVFKG-UHFFFAOYSA-N 644523 5-(3-(4-((3- fluoro-5- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 118 Casein kinase II subunit alpha [2-329] 0.747 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644523&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 169018114 490946855 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364976 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(F)c(OC(F)(F)F)c(F)c1)c1ccncc21 InChI=1S/C28H25F5N4O4/c29-22-9-16(10-23(30)25(22)41-28(31,32)33)12-34-6-1-2-8-40-18-14-37(15-18)26-20-5-7-35-13-21(20)19-4-3-17(27(38)39)11-24(19)36-26/h3-5,7,9-11,13,18,34H,1-2,6,8,12,14-15H2,(H,38,39) KPKJNCKJNAZTGG-UHFFFAOYSA-N 644524 5-(3-(4-((3,5- difluoro-4- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 119 Casein kinase II subunit alpha [2-329] 0.516 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644524&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915033 490946856 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364978 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(Cl)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C28H26ClF3N4O4/c29-19-9-17(10-20(12-19)40-28(30,31)32)13-33-6-1-2-8-39-21-15-36(16-21)26-23-5-7-34-14-24(23)22-4-3-18(27(37)38)11-25(22)35-26/h3-5,7,9-12,14,21,33H,1-2,6,8,13,15-16H2,(H,37,38) XLHTXXNIKXXVAS-UHFFFAOYSA-N 644525 5-(3-(4-((3- chloro-5- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 120 Casein kinase II subunit alpha [2-329] 0.493 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644525&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915156 490946857 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364980 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1ccc(OC(F)(F)F)c(Br)c1)c1ccncc21 InChI=1S/C28H26BrF3N4O4/c29-23-11-17(3-6-25(23)40-28(30,31)32)13-33-8-1-2-10-39-19-15-36(16-19)26-21-7-9-34-14-22(21)20-5-4-18(27(37)38)12-24(20)35-26/h3-7,9,11-12,14,19,33H,1-2,8,10,13,15-16H2,(H,37,38) JLUCPOPZBUWANE-UHFFFAOYSA-N 644526 5-(3-(4-((3- bromo-4- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 121 Casein kinase II subunit alpha [2-329] 0.505 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644526&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915132 490946858 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364982 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(OC(F)(F)F)cc(c1)C1CC1)c1ccncc21 InChI=1S/C31H31F3N4O4/c32-31(33,34)42-23-12-19(11-22(13-23)20-3-4-20)15-35-8-1-2-10-41-24-17-38(18-24)29-26-7-9-36-16-27(26)25-6-5-21(30(39)40)14-28(25)37-29/h5-7,9,11-14,16,20,24,35H,1-4,8,10,15,17-18H2,(H,39,40) OOAUCNDIWGBVHF-UHFFFAOYSA-N 644527 5-(3-(4-((3- cyclopropyl-5- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 122 Casein kinase II subunit alpha [2-329] 1.26 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644527&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915081 490946859 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364984 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CO)ccc1Cl)c1ccncc21 InChI=1S/C27H30ClN5O3/c28-24-6-3-18(17-34)13-20(24)15-30-8-1-2-11-36-12-10-32-27-22-7-9-31-16-23(22)21-5-4-19(26(29)35)14-25(21)33-27/h3-7,9,13-14,16,30,34H,1-2,8,10-12,15,17H2,(H2,29,35)(H,32,33) PKFGJPJBELFCKY-UHFFFAOYSA-N 644528 5-((2-(4-((2-chloro- 5-(hydroxymethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 123 Casein kinase II subunit alpha [2-329] 71.7 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644528&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915202 490946860 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364986 NC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(Cl)cc(CO)c1)c1ccncc21 InChI=1S/C28H30ClN5O3/c29-21-10-18(9-19(11-21)17-35)13-31-6-1-2-8-37-22-15-34(16-22)28-24-5-7-32-14-25(24)23-4-3-20(27(30)36)12-26(23)33-28/h3-5,7,9-12,14,22,31,35H,1-2,6,8,13,15-17H2,(H2,30,36) SSMQRWPVVYHQOU-UHFFFAOYSA-N 644529 5-(3-(4-((3- chloro-5- (hydroxy- methyl) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8- carboxamide::US11866436, Example 124 Casein kinase II subunit alpha [2-329] 75.3 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644529&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915280 490946861 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364988 NC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(F)cc(CO)c1)c1ccncc21 InChI=1S/C28H30FN5O3/c29-21-10-18(9-19(11-21)17-35)13-31-6-1-2-8-37-22-15-34(16-22)28-24-5-7-32-14-25(24)23-4-3-20(27(30)36)12-26(23)33-28/h3-5,7,9-12,14,22,31,35H,1-2,6,8,13,15-17H2,(H2,30,36) GVAGYBSZWYSWEQ-UHFFFAOYSA-N 644530 5-(3-(4-((3- fluoro-5- (hydroxy- methyl) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8- carboxamide::US11866436, Example 125 Casein kinase II subunit alpha [2-329] 189 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644530&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915018 490946862 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364990 NC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(CO)cc(c1)C(F)(F)F)c1ccncc21 InChI=1S/C29H30F3N5O3/c30-29(31,32)21-10-18(9-19(11-21)17-38)13-34-6-1-2-8-40-22-15-37(16-22)28-24-5-7-35-14-25(24)23-4-3-20(27(33)39)12-26(23)36-28/h3-5,7,9-12,14,22,34,38H,1-2,6,8,13,15-17H2,(H2,33,39) LRCUOTROWBXXMI-UHFFFAOYSA-N 644531 5-(3-(4-((3- (hydroxy- methyl)-5- (trifluoro- methyl) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8- carboxamide::US11866436, Example 126 Casein kinase II subunit alpha [2-329] 88.3 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644531&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915161 490946863 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364992 Cc1cc(CNCCCCOC2CN(C2)c2nc3cc(ccc3c3cnccc23)C(N)=O)cc(CC#N)c1 InChI=1S/C30H32N6O2/c1-20-12-21(6-8-31)14-22(13-20)16-33-9-2-3-11-38-24-18-36(19-24)30-26-7-10-34-17-27(26)25-5-4-23(29(32)37)15-28(25)35-30/h4-5,7,10,12-15,17,24,33H,2-3,6,9,11,16,18-19H2,1H3,(H2,32,37) CTMIHQOVGICMNG-UHFFFAOYSA-N 644532 5-(3-(4-((3- (cyanomethyl)- 5- methylbenzyl) amino)butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8- carboxamide::US11866436, Example 127 Casein kinase II subunit alpha [2-329] 43.0 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644532&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915073 490946864 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364994 NC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(F)cc(CC#N)c1)c1ccncc21 InChI=1S/C29H29FN6O2/c30-22-12-19(5-7-31)11-20(13-22)15-33-8-1-2-10-38-23-17-36(18-23)29-25-6-9-34-16-26(25)24-4-3-21(28(32)37)14-27(24)35-29/h3-4,6,9,11-14,16,23,33H,1-2,5,8,10,15,17-18H2,(H2,32,37) GBVJYBSBYUKDMI-UHFFFAOYSA-N 644533 5-(3-(4-((3- (cyanomethyl)- 5- fluorobenzyl) amino)butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8- carboxamide::US11866436, Example 128 Casein kinase II subunit alpha [2-329] 61.0 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644533&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915278 490946865 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364996 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(Cl)cc(c1)C1(CC1)C#N)c1ccncc21 InChI=1S/C30H29ClN4O4/c31-23-14-20(13-22(16-23)30(19-32)6-7-30)17-33-8-1-2-10-38-11-12-39-28-25-5-9-34-18-26(25)24-4-3-21(29(36)37)15-27(24)35-28/h3-5,9,13-16,18,33H,1-2,6-8,10-12,17H2,(H,36,37) DKVWFXPMJDEBDJ-UHFFFAOYSA-N 644534 5-(2-(4-((3- chloro-5-(1- cyano- cyclopropyl) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 129 Casein kinase II subunit alpha [2-329] 0.333 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644534&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915107 490946866 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364998 CC(C)(C#N)c1cc(Cl)cc(CNCCCCOCCOc2nc3cc(ccc3c3cnccc23)C(O)=O)c1 InChI=1S/C30H31ClN4O4/c1-30(2,19-32)22-13-20(14-23(31)16-22)17-33-8-3-4-10-38-11-12-39-28-25-7-9-34-18-26(25)24-6-5-21(29(36)37)15-27(24)35-28/h5-7,9,13-16,18,33H,3-4,8,10-12,17H2,1-2H3,(H,36,37) FFIUILKFHSTZEP-UHFFFAOYSA-N 644535 5-(2-(4-((3- chloro-5-(2- cyanopropan- 2-yl) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 130 Casein kinase II subunit alpha [2-329] 1.40 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644535&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915040 490946867 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365000 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1ccc(OC(F)(F)F)c(c1)C1CC1)c1ccncc21 InChI=1S/C30H30F3N3O5/c31-30(32,33)41-27-8-3-19(15-24(27)20-4-5-20)17-34-10-1-2-12-39-13-14-40-28-23-9-11-35-18-25(23)22-7-6-21(29(37)38)16-26(22)36-28/h3,6-9,11,15-16,18,20,34H,1-2,4-5,10,12-14,17H2,(H,37,38) DKFCBLGIHHZPIR-UHFFFAOYSA-N 644536 5-(2-(4-((3- cyclopropyl-4- (trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 131 Casein kinase II subunit alpha [2-329] 0.432 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644536&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915157 490946868 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365002 Cc1cc(CNCCCCOCCOc2nc3cc(ccc3c3cnccc23)C(O)=O)ccc1OC(F)(F)F InChI=1S/C28H28F3N3O5/c1-18-14-19(4-7-25(18)39-28(29,30)31)16-32-9-2-3-11-37-12-13-38-26-22-8-10-33-17-23(22)21-6-5-20(27(35)36)15-24(21)34-26/h4-8,10,14-15,17,32H,2-3,9,11-13,16H2,1H3,(H,35,36) CRHJUMKCZAOJLP-UHFFFAOYSA-N 644537 5-(2-(4-((3- methyl-4- (trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 132 Casein kinase II subunit alpha [2-329] 0.370 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644537&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915166 490946869 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365004 COc1cc(CNCCCCOCCOc2nc3cc(ccc3c3cnccc23)C(O)=O)ccc1OC(F)(F)F InChI=1S/C28H28F3N3O6/c1-37-25-14-18(4-7-24(25)40-28(29,30)31)16-32-9-2-3-11-38-12-13-39-26-21-8-10-33-17-22(21)20-6-5-19(27(35)36)15-23(20)34-26/h4-8,10,14-15,17,32H,2-3,9,11-13,16H2,1H3,(H,35,36) MXKUOZKGRRIYDM-UHFFFAOYSA-N 644538 5-(2-(4-((3- methoxy-4- (trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 133 Casein kinase II subunit alpha [2-329] 0.403 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644538&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915105 490946870 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365006 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(Cl)c(Cl)c(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C27H24Cl2F3N3O5/c28-21-11-16(12-23(24(21)29)40-27(30,31)32)14-33-6-1-2-8-38-9-10-39-25-19-5-7-34-15-20(19)18-4-3-17(26(36)37)13-22(18)35-25/h3-5,7,11-13,15,33H,1-2,6,8-10,14H2,(H,36,37) AEYBYRSGXQFSBA-UHFFFAOYSA-N 644539 5-(2-(4-((3,4- dichloro-5- (trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 134 Casein kinase II subunit alpha [2-329] 0.532 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644539&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915097 490946871 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365008 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CC#N)cc(c1)C1CC1)c1ccncc21 InChI=1S/C31H34N6O2/c32-9-7-21-15-22(17-25(16-21)23-3-4-23)19-34-10-1-2-13-39-14-12-36-31-27-8-11-35-20-28(27)26-6-5-24(30(33)38)18-29(26)37-31/h5-6,8,11,15-18,20,23,34H,1-4,7,10,12-14,19H2,(H2,33,38)(H,36,37) GQQZFYMMDHSYAK-UHFFFAOYSA-N 644540 5-((2-(4-((3- (cyanomethyl)- 5-cyclopropyl benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 135 Casein kinase II subunit alpha [2-329] 0.930 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644540&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914959 490946872 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365010 CCOc1cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)cc(CC#N)c1 InChI=1S/C30H34N6O3/c1-2-39-24-16-21(7-9-31)15-22(17-24)19-33-10-3-4-13-38-14-12-35-30-26-8-11-34-20-27(26)25-6-5-23(29(32)37)18-28(25)36-30/h5-6,8,11,15-18,20,33H,2-4,7,10,12-14,19H2,1H3,(H2,32,37)(H,35,36) MHWCLOZXXSCEMP-UHFFFAOYSA-N 644541 5-((2-(4-((3- (cyanomethyl)- 5-ethoxybenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 136 Casein kinase II subunit alpha [2-329] 0.736 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644541&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915102 490946873 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365012 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CO)cc(c1)C1CC1)c1ccncc21 InChI=1S/C30H35N5O3/c31-29(37)23-5-6-25-27-18-33-9-7-26(27)30(35-28(25)16-23)34-10-12-38-11-2-1-8-32-17-20-13-21(19-36)15-24(14-20)22-3-4-22/h5-7,9,13-16,18,22,32,36H,1-4,8,10-12,17,19H2,(H2,31,37)(H,34,35) YLFMFJIZCIFNHW-UHFFFAOYSA-N 644542 5-((2-(4-((3- cyclopropyl-5- (hydroxymethyl) benzyl)amino) butoxy)ethyl) amino)benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 137 Casein kinase II subunit alpha [2-329] 1.97 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644542&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915036 490946874 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365014 C[C@@H](C#N)c1cc(Cl)cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)c1 InChI=1S/C29H31ClN6O2/c1-19(16-31)22-12-20(13-23(30)14-22)17-33-7-2-3-10-38-11-9-35-29-25-6-8-34-18-26(25)24-5-4-21(28(32)37)15-27(24)36-29/h4-6,8,12-15,18-19,33H,2-3,7,9-11,17H2,1H3,(H2,32,37)(H,35,36)/t19-/m0/s1 XEYUDLCFZLNWLI-IBGZPJMESA-N 644543 (R)-5-((2-(4-((3-chloro-5-(1-cyanoethyl)benzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 138 Casein kinase II subunit alpha [2-329] 0.657 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644543&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915131 490946875 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365016 C[C@H](C#N)c1cc(Cl)cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)c1 InChI=1S/C29H31ClN6O2/c1-19(16-31)22-12-20(13-23(30)14-22)17-33-7-2-3-10-38-11-9-35-29-25-6-8-34-18-26(25)24-5-4-21(28(32)37)15-27(24)36-29/h4-6,8,12-15,18-19,33H,2-3,7,9-11,17H2,1H3,(H2,32,37)(H,35,36)/t19-/m1/s1 XEYUDLCFZLNWLI-LJQANCHMSA-N 644544 (S)-5-((2-(4-((3-chloro-5-(1-cyanoethyl)benzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 139 Casein kinase II subunit alpha [2-329] 0.600 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644544&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915020 490946876 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365018 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CC#N)cc(OCC(F)(F)F)c1)c1ccncc21 InChI=1S/C30H31F3N6O3/c31-30(32,33)19-42-23-14-20(5-7-34)13-21(15-23)17-36-8-1-2-11-41-12-10-38-29-25-6-9-37-18-26(25)24-4-3-22(28(35)40)16-27(24)39-29/h3-4,6,9,13-16,18,36H,1-2,5,8,10-12,17,19H2,(H2,35,40)(H,38,39) LAAYMDCRAVMIJU-UHFFFAOYSA-N 644545 5-((2-(4-((3- (cyanomethyl)- 5-(2,2,2- trifluoroethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 140 Casein kinase II subunit alpha [2-329] 0.349 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644545&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915261 490946877 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365020 C[C@H](COCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)Nc1nc2cc(ccc2c2cnccc12)C(N)=O InChI=1S/C28H29ClF3N5O3/c1-17(16-39-11-3-2-9-34-14-18-4-7-25(23(29)12-18)40-28(30,31)32)36-27-21-8-10-35-15-22(21)20-6-5-19(26(33)38)13-24(20)37-27/h4-8,10,12-13,15,17,34H,2-3,9,11,14,16H2,1H3,(H2,33,38)(H,36,37)/t17-/m1/s1 KEXVDKQNGWPBHW-QGZVFWFLSA-N 644546 (R)-5-((1-(4-((3-chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)propan-2-yl)amino)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 141 Casein kinase II subunit alpha [2-329] 3.44 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644546&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915039 490946878 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365022 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1ccc(OC(F)(F)F)c(c1)C1CC1)c1ccncc21 InChI=1S/C31H31F3N4O4/c32-31(33,34)42-28-8-3-19(13-25(28)20-4-5-20)15-35-10-1-2-12-41-22-17-38(18-22)29-24-9-11-36-16-26(24)23-7-6-21(30(39)40)14-27(23)37-29/h3,6-9,11,13-14,16,20,22,35H,1-2,4-5,10,12,15,17-18H2,(H,39,40) HHGDGVNOHBAHKJ-UHFFFAOYSA-N 644547 5-(3-(4-((3- cyclopropyl-4- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 142 Casein kinase II subunit alpha [2-329] 0.457 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644547&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914962 490946879 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365024 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(Br)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C28H26BrF3N4O4/c29-19-9-17(10-20(12-19)40-28(30,31)32)13-33-6-1-2-8-39-21-15-36(16-21)26-23-5-7-34-14-24(23)22-4-3-18(27(37)38)11-25(22)35-26/h3-5,7,9-12,14,21,33H,1-2,6,8,13,15-16H2,(H,37,38) FFZALTJLOHVCOT-UHFFFAOYSA-N 644548 5-(3-(4-((3- bromo-5- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 143 Casein kinase II subunit alpha [2-329] 0.857 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644548&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915026 490946880 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365026 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1ccc(Cl)c(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C28H26ClF3N4O4/c29-23-6-3-17(11-25(23)40-28(30,31)32)13-33-8-1-2-10-39-19-15-36(16-19)26-21-7-9-34-14-22(21)20-5-4-18(27(37)38)12-24(20)35-26/h3-7,9,11-12,14,19,33H,1-2,8,10,13,15-16H2,(H,37,38) AGSOXCIDVSMLSA-UHFFFAOYSA-N 644549 5-(3-(4-((4- chloro-3- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 144 Casein kinase II subunit alpha [2-329] 0.796 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644549&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915111 490946881 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365028 Cc1cc(CNCCCCOC2CN(C2)c2nc3cc(ccc3c3cnccc23)C(O)=O)ccc1OC(F)(F)F InChI=1S/C29H29F3N4O4/c1-18-12-19(4-7-26(18)40-29(30,31)32)14-33-9-2-3-11-39-21-16-36(17-21)27-23-8-10-34-15-24(23)22-6-5-20(28(37)38)13-25(22)35-27/h4-8,10,12-13,15,21,33H,2-3,9,11,14,16-17H2,1H3,(H,37,38) RPECODXSMBBMSO-UHFFFAOYSA-N 644550 5-(3-(4-((3- methyl-4- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 145 Casein kinase II subunit alpha [2-329] 1.04 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644550&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914960 490946882 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365030 COc1cc(CNCCCCOC2CN(C2)c2nc3cc(ccc3c3cnccc23)C(O)=O)ccc1OC(F)(F)F InChI=1S/C29H29F3N4O5/c1-39-26-12-18(4-7-25(26)41-29(30,31)32)14-33-9-2-3-11-40-20-16-36(17-20)27-22-8-10-34-15-23(22)21-6-5-19(28(37)38)13-24(21)35-27/h4-8,10,12-13,15,20,33H,2-3,9,11,14,16-17H2,1H3,(H,37,38) KWDHKMSSYPOWFY-UHFFFAOYSA-N 644551 5-(3-(4-((3- methoxy-4- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 146 Casein kinase II subunit alpha [2-329] 0.934 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644551&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915137 490946883 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365032 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(Cl)c(Cl)c(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C28H25Cl2F3N4O4/c29-22-9-16(10-24(25(22)30)41-28(31,32)33)12-34-6-1-2-8-40-18-14-37(15-18)26-20-5-7-35-13-21(20)19-4-3-17(27(38)39)11-23(19)36-26/h3-5,7,9-11,13,18,34H,1-2,6,8,12,14-15H2,(H,38,39) DGDLNCAQWKWKOH-UHFFFAOYSA-N 644552 5-(3-(4-((3,4- dichloro-5- (trifluoro- methoxy) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 147 Casein kinase II subunit alpha [2-329] 0.696 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644552&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915181 490946884 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365034 C[C@@H](COCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)Nc1nc2cc(ccc2c2cnccc12)C(N)=O InChI=1S/C28H29ClF3N5O3/c1-17(16-39-11-3-2-9-34-14-18-4-7-25(23(29)12-18)40-28(30,31)32)36-27-21-8-10-35-15-22(21)20-6-5-19(26(33)38)13-24(20)37-27/h4-8,10,12-13,15,17,34H,2-3,9,11,14,16H2,1H3,(H2,33,38)(H,36,37)/t17-/m0/s1 KEXVDKQNGWPBHW-KRWDZBQOSA-N 644553 (S)-5-((1-(4-((3-Chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)propan-2-yl)amino)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 148 Casein kinase II subunit alpha [2-329] 0.559 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644553&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914976 490946885 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365036 CC(C)(COCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)Nc1nc2cc(ccc2c2cnccc12)C(O)=O InChI=1S/C29H30ClF3N4O4/c1-28(2,17-40-12-4-3-10-34-15-18-5-8-25(23(30)13-18)41-29(31,32)33)37-26-21-9-11-35-16-22(21)20-7-6-19(27(38)39)14-24(20)36-26/h5-9,11,13-14,16,34H,3-4,10,12,15,17H2,1-2H3,(H,36,37)(H,38,39) ZZVAFDDAQGHPFE-UHFFFAOYSA-N 644554 5-((1-(4-((3-Chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)-2-methylpropan-2-yl)amino)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 149 Casein kinase II subunit alpha [2-329] 0.494 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644554&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914980 490946886 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365038 CCc1cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)cc(CC#N)c1 InChI=1S/C30H34N6O2/c1-2-21-15-22(7-9-31)17-23(16-21)19-33-10-3-4-13-38-14-12-35-30-26-8-11-34-20-27(26)25-6-5-24(29(32)37)18-28(25)36-30/h5-6,8,11,15-18,20,33H,2-4,7,10,12-14,19H2,1H3,(H2,32,37)(H,35,36) VGYVKCFHEMTBSO-UHFFFAOYSA-N 644555 5-((2-(4-((3-(Cyanomethyl)-5-ethylbenzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 150 Casein kinase II subunit alpha [2-329] 0.810 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644555&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915286 490946887 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365040 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CC#N)cc(CC3CC3)c1)c1ccncc21 InChI=1S/C32H36N6O2/c33-9-7-23-16-24(15-22-3-4-22)18-25(17-23)20-35-10-1-2-13-40-14-12-37-32-28-8-11-36-21-29(28)27-6-5-26(31(34)39)19-30(27)38-32/h5-6,8,11,16-19,21-22,35H,1-4,7,10,12-15,20H2,(H2,34,39)(H,37,38) YGMXDDPCCMVMGF-UHFFFAOYSA-N 644556 5-((2-(4-((3-(Cyanomethyl)-5-(cyclopropylmethyl)benzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 151 Casein kinase II subunit alpha [2-329] 0.984 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644556&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915049 490946888 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365042 CC(C)(COCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)Nc1nc2cc(ccc2c2cnccc12)C(N)=O InChI=1S/C29H31ClF3N5O3/c1-28(2,17-40-12-4-3-10-35-15-18-5-8-25(23(30)13-18)41-29(31,32)33)38-27-21-9-11-36-16-22(21)20-7-6-19(26(34)39)14-24(20)37-27/h5-9,11,13-14,16,35H,3-4,10,12,15,17H2,1-2H3,(H2,34,39)(H,37,38) HBMHNAPZOMEESB-UHFFFAOYSA-N 644557 5-((1-(4-((3-Chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)-2-methylpropan-2-yl)amino)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 152 Casein kinase II subunit alpha [2-329] 0.555 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644557&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915294 490946889 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365044 COCc1cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)cc(CC#N)c1 InChI=1S/C30H34N6O3/c1-38-20-23-15-21(6-8-31)14-22(16-23)18-33-9-2-3-12-39-13-11-35-30-26-7-10-34-19-27(26)25-5-4-24(29(32)37)17-28(25)36-30/h4-5,7,10,14-17,19,33H,2-3,6,9,11-13,18,20H2,1H3,(H2,32,37)(H,35,36) OHZYECRAEHSCIB-UHFFFAOYSA-N 644558 5-((2-(4-((3- (cyanomethyl)- 5-(methoxymethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 153 Casein kinase II subunit alpha [2-329] 4.20 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644558&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915303 490946890 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365046 C[C@H](COCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)Oc1nc2cc(ccc2c2cnccc12)C(O)=O InChI=1S/C28H27ClF3N3O5/c1-17(16-38-11-3-2-9-33-14-18-4-7-25(23(29)12-18)40-28(30,31)32)39-26-21-8-10-34-15-22(21)20-6-5-19(27(36)37)13-24(20)35-26/h4-8,10,12-13,15,17,33H,2-3,9,11,14,16H2,1H3,(H,36,37)/t17-/m1/s1 CAFIVVHIKSBSPE-QGZVFWFLSA-N 644559 (R)-5-((1-(4-((3-chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)propan-2-yl)oxy)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 154 Casein kinase II subunit alpha [2-329] 0.749 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644559&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915093 490946891 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365048 C[C@H](COCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)Oc1nc2cc(ccc2c2cnccc12)C(N)=O InChI=1S/C28H28ClF3N4O4/c1-17(16-38-11-3-2-9-34-14-18-4-7-25(23(29)12-18)40-28(30,31)32)39-27-21-8-10-35-15-22(21)20-6-5-19(26(33)37)13-24(20)36-27/h4-8,10,12-13,15,17,34H,2-3,9,11,14,16H2,1H3,(H2,33,37)/t17-/m1/s1 JWARDYDEHQOHAV-QGZVFWFLSA-N 644560 (R)-5-((1-(4-((3-Chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)propan-2-yl)oxy)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 155 Casein kinase II subunit alpha [2-329] 17.8 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644560&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915008 490946892 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365050 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(OC(F)(F)F)cc(c1)C#N)c1ccncc21 InChI=1S/C28H27F3N6O3/c29-28(30,31)40-21-12-18(15-32)11-19(13-21)16-34-6-1-2-9-39-10-8-36-27-23-5-7-35-17-24(23)22-4-3-20(26(33)38)14-25(22)37-27/h3-5,7,11-14,17,34H,1-2,6,8-10,16H2,(H2,33,38)(H,36,37) LUKCVJMSEKMIBS-UHFFFAOYSA-N 644561 5-((2-(4-((3- cyano-5- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 156 Casein kinase II subunit alpha [2-329] 0.840 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644561&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915159 490946893 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365052 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(OCCO)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C29H32F3N5O5/c30-29(31,32)42-22-14-19(13-21(16-22)41-12-9-38)17-34-6-1-2-10-40-11-8-36-28-24-5-7-35-18-25(24)23-4-3-20(27(33)39)15-26(23)37-28/h3-5,7,13-16,18,34,38H,1-2,6,8-12,17H2,(H2,33,39)(H,36,37) LYTQRTLUAYFMPC-UHFFFAOYSA-N 644562 5-((2-(4-((3-(2- hydroxyethoxy)-5- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 157 Casein kinase II subunit alpha [2-329] 0.553 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644562&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915293 490946894 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365054 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(Cc3cocn3)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C31H31F3N6O4/c32-31(33,34)44-24-13-20(12-23-18-43-19-39-23)11-21(14-24)16-36-6-1-2-9-42-10-8-38-30-26-5-7-37-17-27(26)25-4-3-22(29(35)41)15-28(25)40-30/h3-5,7,11,13-15,17-19,36H,1-2,6,8-10,12,16H2,(H2,35,41)(H,38,40) AZWZPAVXGSZOTF-UHFFFAOYSA-N 644563 5-((2-(4-((3- (oxazol-4- ylmethyl)-5- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 158 Casein kinase II subunit alpha [2-329] 0.593 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644563&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 169018111 490946895 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365056 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(Cc3cnco3)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C31H31F3N6O4/c32-31(33,34)44-23-12-20(13-24-17-38-19-43-24)11-21(14-23)16-36-6-1-2-9-42-10-8-39-30-26-5-7-37-18-27(26)25-4-3-22(29(35)41)15-28(25)40-30/h3-5,7,11-12,14-15,17-19,36H,1-2,6,8-10,13,16H2,(H2,35,41)(H,39,40) MTIHHEYRFCWOGO-UHFFFAOYSA-N 644564 5-((2-(4-((3- (oxazol-5- ylmethyl)-5- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 159 Casein kinase II subunit alpha [2-329] 0.217 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644564&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 169018110 490946896 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365058 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(OC(F)(F)F)cc(c1)C#N)c1ccncc21 InChI=1S/C28H26F3N5O4/c29-28(30,31)40-21-12-18(15-32)11-19(13-21)16-34-6-1-2-8-38-9-10-39-27-23-5-7-35-17-24(23)22-4-3-20(26(33)37)14-25(22)36-27/h3-5,7,11-14,17,34H,1-2,6,8-10,16H2,(H2,33,37) DPAACUBZISGZEC-UHFFFAOYSA-N 644565 5-(2-(4-((3- cyano-5- (trifluorometh- oxy)benzyl) amino)butoxy) ethoxy) benzo[c][2,6] naphthyridine-8- carboxamide::US11866436, Example 160 Casein kinase II subunit alpha [2-329] 1.03 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644565&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915060 490946897 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365060 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(OCCO)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C29H31F3N4O6/c30-29(31,32)42-22-14-19(13-21(16-22)40-10-8-37)17-34-6-1-2-9-39-11-12-41-28-24-5-7-35-18-25(24)23-4-3-20(27(33)38)15-26(23)36-28/h3-5,7,13-16,18,34,37H,1-2,6,8-12,17H2,(H2,33,38) MMVVQQWBXCXNQP-UHFFFAOYSA-N 644566 5-(2-(4-((3- (2- hydroxyethoxy)- 5- (trifluoro- methoxy) benzyl) amino)butoxy) ethoxy) benzo[c][2,6] naphthyridine-8- carboxamide::US11866436, Example 161 Casein kinase II subunit alpha [2-329] 0.661 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644566&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915087 490946898 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365062 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(Cc3cnco3)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C31H30F3N5O5/c32-31(33,34)44-23-12-20(13-24-17-38-19-43-24)11-21(14-23)16-36-6-1-2-8-41-9-10-42-30-26-5-7-37-18-27(26)25-4-3-22(29(35)40)15-28(25)39-30/h3-5,7,11-12,14-15,17-19,36H,1-2,6,8-10,13,16H2,(H2,35,40) AGRIQCAANNNWID-UHFFFAOYSA-N 644567 5-(2-(4-((3- (oxazol-5- ylmethyl)- 5- (trifluoro- methoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine-8- carboxamide::US11866436, Example 162 Casein kinase II subunit alpha [2-329] 0.602 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644567&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 169018118 490946899 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365064 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(Cc3cocn3)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C31H30F3N5O5/c32-31(33,34)44-24-13-20(12-23-18-42-19-38-23)11-21(14-24)16-36-6-1-2-8-41-9-10-43-30-26-5-7-37-17-27(26)25-4-3-22(29(35)40)15-28(25)39-30/h3-5,7,11,13-15,17-19,36H,1-2,6,8-10,12,16H2,(H2,35,40) WSGQMWYUADBITO-UHFFFAOYSA-N 644568 5-(2-(4-((3- (oxazol-4- ylmethyl)- 5- (trifluoro- methoxy)benzyl) amino)butoxy) ethoxy) benzo[c][2,6] naphthyridine-8- carboxamide::US11866436, Example 163 Casein kinase II subunit alpha [2-329] 0.524 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644568&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 169018116 490946900 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365066 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(CCO)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C29H31F3N4O5/c30-29(31,32)41-22-14-19(6-9-37)13-20(15-22)17-34-7-1-2-10-39-11-12-40-28-24-5-8-35-18-25(24)23-4-3-21(27(33)38)16-26(23)36-28/h3-5,8,13-16,18,34,37H,1-2,6-7,9-12,17H2,(H2,33,38) PYVXEDIVYACQPU-UHFFFAOYSA-N 644569 5-(2-(4-((3- (2- hydroxyethyl)- 5- (trifluoro- methoxy)benzyl) amino)butoxy) ethoxy) benzo[c][2,6] naphthyridine-8- carboxamide::US11866436, Example 164 Casein kinase II subunit alpha [2-329] 1.05 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644569&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 169018115 490946901 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365068 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CCO)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C29H32F3N5O4/c30-29(31,32)41-22-14-19(6-10-38)13-20(15-22)17-34-7-1-2-11-40-12-9-36-28-24-5-8-35-18-25(24)23-4-3-21(27(33)39)16-26(23)37-28/h3-5,8,13-16,18,34,38H,1-2,6-7,9-12,17H2,(H2,33,39)(H,36,37) YXLGGUSAIJYAAD-UHFFFAOYSA-N 644570 5-((2-(4-((3-(2- hydroxyethyl)-5- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 165 Casein kinase II subunit alpha [2-329] 0.390 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644570&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915172 490946902 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365070 C[C@@H](COCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)Oc1nc2cc(ccc2c2cnccc12)C(O)=O InChI=1S/C28H27ClF3N3O5/c1-17(16-38-11-3-2-9-33-14-18-4-7-25(23(29)12-18)40-28(30,31)32)39-26-21-8-10-34-15-22(21)20-6-5-19(27(36)37)13-24(20)35-26/h4-8,10,12-13,15,17,33H,2-3,9,11,14,16H2,1H3,(H,36,37)/t17-/m0/s1 CAFIVVHIKSBSPE-KRWDZBQOSA-N 644571 (S)-5-((1-(4-((3-Chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)propan-2-yl)oxy)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 166 Casein kinase II subunit alpha [2-329] 0.485 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644571&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915135 490946903 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365072 C[C@@H](COCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)Oc1nc2cc(ccc2c2cnccc12)C(N)=O InChI=1S/C28H28ClF3N4O4/c1-17(16-38-11-3-2-9-34-14-18-4-7-25(23(29)12-18)40-28(30,31)32)39-27-21-8-10-35-15-22(21)20-6-5-19(26(33)37)13-24(20)36-27/h4-8,10,12-13,15,17,34H,2-3,9,11,14,16H2,1H3,(H2,33,37)/t17-/m0/s1 JWARDYDEHQOHAV-KRWDZBQOSA-N 644572 (S)-5-((1-(4-((3-Chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)propan-2-yl)oxy)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 167 Casein kinase II subunit alpha [2-329] 0.847 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644572&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915222 490946904 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365074 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(OC(F)(F)F)cc(c1)C(N)=O)c1ccncc21 InChI=1S/C28H29F3N6O4/c29-28(30,31)41-20-12-17(11-19(13-20)26(33)39)15-34-6-1-2-9-40-10-8-36-27-22-5-7-35-16-23(22)21-4-3-18(25(32)38)14-24(21)37-27/h3-5,7,11-14,16,34H,1-2,6,8-10,15H2,(H2,32,38)(H2,33,39)(H,36,37) BYUOTROFDJYVHI-UHFFFAOYSA-N 644573 5-((2-(4-((3- carbamoyl-5- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 168 Casein kinase II subunit alpha [2-329] 0.479 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644573&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915043 490946905 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365076 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(OC(F)(F)F)cc(c1)C(N)=O)c1ccncc21 InChI=1S/C28H28F3N5O5/c29-28(30,31)41-20-12-17(11-19(13-20)26(33)38)15-34-6-1-2-8-39-9-10-40-27-22-5-7-35-16-23(22)21-4-3-18(25(32)37)14-24(21)36-27/h3-5,7,11-14,16,34H,1-2,6,8-10,15H2,(H2,32,37)(H2,33,38) NETTZHRDGQCXRM-UHFFFAOYSA-N 644574 5-(2-(4-((3-Carbamoyl-5-(trifluoromethoxy)benzyl)amino)butoxy)ethoxy)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 169 Casein kinase II subunit alpha [2-329] 1.13 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644574&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914983 490946906 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365078 NC(=O)Cc1cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)cc(OC(F)(F)F)c1 InChI=1S/C29H31F3N6O4/c30-29(31,32)42-21-12-18(14-26(33)39)11-19(13-21)16-35-6-1-2-9-41-10-8-37-28-23-5-7-36-17-24(23)22-4-3-20(27(34)40)15-25(22)38-28/h3-5,7,11-13,15,17,35H,1-2,6,8-10,14,16H2,(H2,33,39)(H2,34,40)(H,37,38) UBUPBYVJHDFZSU-UHFFFAOYSA-N 644575 5-((2-(4-((3-(2-Amino-2-oxoethyl)-5-(trifluoromethoxy)benzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 170 Casein kinase II subunit alpha [2-329] 0.549 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644575&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915244 490946907 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365080 NC(=O)Cc1cc(CNCCCCOCCOc2nc3cc(ccc3c3cnccc23)C(N)=O)cc(OC(F)(F)F)c1 InChI=1S/C29H30F3N5O5/c30-29(31,32)42-21-12-18(14-26(33)38)11-19(13-21)16-35-6-1-2-8-40-9-10-41-28-23-5-7-36-17-24(23)22-4-3-20(27(34)39)15-25(22)37-28/h3-5,7,11-13,15,17,35H,1-2,6,8-10,14,16H2,(H2,33,38)(H2,34,39) SDKSLRSDCNLLCJ-UHFFFAOYSA-N 644576 5-(2-(4-((3-(2-Amino-2-oxoethyl)-5-(trifluoromethoxy)benzyl)amino)butoxy)ethoxy)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 171 Casein kinase II subunit alpha [2-329] 1.17 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644576&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915265 490946908 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365082 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(Cn3ccnc3)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C31H32F3N7O3/c32-31(33,34)44-24-14-21(13-22(15-24)19-41-10-8-38-20-41)17-36-6-1-2-11-43-12-9-39-30-26-5-7-37-18-27(26)25-4-3-23(29(35)42)16-28(25)40-30/h3-5,7-8,10,13-16,18,20,36H,1-2,6,9,11-12,17,19H2,(H2,35,42)(H,39,40) FZYDRVDEQBODTG-UHFFFAOYSA-N 644577 5-((2-(4-((3- ((1H-imidazol- 1-yl)methyl)-5- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 172 Casein kinase II subunit alpha [2-329] 0.265 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644577&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915187 490946909 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365084 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(Cc3ccoc3)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C32H32F3N5O4/c33-32(34,35)44-25-15-22(13-21-6-11-43-20-21)14-23(16-25)18-37-7-1-2-10-42-12-9-39-31-27-5-8-38-19-28(27)26-4-3-24(30(36)41)17-29(26)40-31/h3-6,8,11,14-17,19-20,37H,1-2,7,9-10,12-13,18H2,(H2,36,41)(H,39,40) JKZSWHYFSJQUBI-UHFFFAOYSA-N 644578 5-((2-(4-((3- (furan-3- ylmethyl)-5- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 173 Casein kinase II subunit alpha [2-329] 0.223 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644578&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915197 490946910 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365086 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(Cn3ccnc3)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C31H31F3N6O4/c32-31(33,34)44-24-14-21(13-22(15-24)19-40-9-8-38-20-40)17-36-6-1-2-10-42-11-12-43-30-26-5-7-37-18-27(26)25-4-3-23(29(35)41)16-28(25)39-30/h3-5,7-9,13-16,18,20,36H,1-2,6,10-12,17,19H2,(H2,35,41) XGSKLLNENBYNCQ-UHFFFAOYSA-N 644579 5-(2-(4-((3- ((1H-imidazol- 1-yl)methyl)-5- (trifluoromethoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine-8- carboxamide::US11866436, Example 174 Casein kinase II subunit alpha [2-329] 0.573 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644579&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914965 490946911 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365088 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(Cc3cn[nH]c3)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C31H32F3N7O3/c32-31(33,34)44-24-13-20(12-22-17-39-40-18-22)11-21(14-24)16-36-6-1-2-9-43-10-8-38-30-26-5-7-37-19-27(26)25-4-3-23(29(35)42)15-28(25)41-30/h3-5,7,11,13-15,17-19,36H,1-2,6,8-10,12,16H2,(H2,35,42)(H,38,41)(H,39,40) AYVLTTZAGWJFCV-UHFFFAOYSA-N 644580 5-((2-(4-((3-((1H-pyrazol-4-yl)methyl)-5-(trifluoromethoxy)benzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 175 Casein kinase II subunit alpha [2-329] 0.201 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644580&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915296 490946912 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365090 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(Cc3ccoc3)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C32H31F3N4O5/c33-32(34,35)44-25-15-22(13-21-6-10-42-20-21)14-23(16-25)18-37-7-1-2-9-41-11-12-43-31-27-5-8-38-19-28(27)26-4-3-24(30(36)40)17-29(26)39-31/h3-6,8,10,14-17,19-20,37H,1-2,7,9,11-13,18H2,(H2,36,40) PFQVXAZAEYOJAK-UHFFFAOYSA-N 644581 5-(2-(4-((3- (furan-3- ylmethyl)-5- (trifluoromethoxy) benzyl)amino) butoxy)ethoxy) benzo[c][2,6] naphthyridine-8- carboxamide::US11866436, Example 176 Casein kinase II subunit alpha [2-329] 0.492 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644581&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915160 490946913 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365092 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(Cc3cn[nH]c3)cc(OC(F)(F)F)c1)c1ccncc21 InChI=1S/C31H31F3N6O4/c32-31(33,34)44-24-13-20(12-22-17-38-39-18-22)11-21(14-24)16-36-6-1-2-8-42-9-10-43-30-26-5-7-37-19-27(26)25-4-3-23(29(35)41)15-28(25)40-30/h3-5,7,11,13-15,17-19,36H,1-2,6,8-10,12,16H2,(H2,35,41)(H,38,39) ZWIVTAZXGZQTLN-UHFFFAOYSA-N 644582 5-(2-(4-((3-((1H-pyrazol-4-yl)methyl)-5-(trifluoromethoxy)benzyl)amino)butoxy)ethoxy)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 177 Casein kinase II subunit alpha [2-329] 0.593 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644582&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915228 490946914 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365094 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(F)c(OC(F)(F)F)c(F)c1)c1ccncc21 InChI=1S/C27H25F5N4O4/c28-21-11-16(12-22(29)24(21)40-27(30,31)32)14-33-6-1-2-9-39-10-8-35-25-19-5-7-34-15-20(19)18-4-3-17(26(37)38)13-23(18)36-25/h3-5,7,11-13,15,33H,1-2,6,8-10,14H2,(H,35,36)(H,37,38) YGVTUORKHNWPJC-UHFFFAOYSA-N 644583 5-((2-(4- ((3,5- difluoro-4- (trifluoro- methoxy) benzyl)amino) butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 178 Casein kinase II subunit alpha [2-329] 0.236 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644583&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915208 490946915 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365096 C[C@H](COCCCCNCc1cc(F)c(OC(F)(F)F)c(F)c1)Oc1nc2cc(ccc2c2cnccc12)C(O)=O InChI=1S/C28H26F5N3O5/c1-16(40-26-20-6-8-35-14-21(20)19-5-4-18(27(37)38)12-24(19)36-26)15-39-9-3-2-7-34-13-17-10-22(29)25(23(30)11-17)41-28(31,32)33/h4-6,8,10-12,14,16,34H,2-3,7,9,13,15H2,1H3,(H,37,38)/t16-/m1/s1 OVPVHNVPZGYWDN-MRXNPFEDSA-N 644584 (R)-5-((1-(4-((3,5-difluoro-4-(trifluoromethoxy)benzyl)amino)butoxy)propan-2-yl)oxy)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 179 Casein kinase II subunit alpha [2-329] 0.494 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644584&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915177 490946916 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365098 C[C@H](COCCCCNCc1ccc(OC(F)(F)F)c(F)c1)Oc1nc2cc(ccc2c2cnccc12)C(O)=O InChI=1S/C28H27F4N3O5/c1-17(16-38-11-3-2-9-33-14-18-4-7-25(23(29)12-18)40-28(30,31)32)39-26-21-8-10-34-15-22(21)20-6-5-19(27(36)37)13-24(20)35-26/h4-8,10,12-13,15,17,33H,2-3,9,11,14,16H2,1H3,(H,36,37)/t17-/m1/s1 GYIWPHYGXVVJQR-QGZVFWFLSA-N 644585 (R)-5-((1-(4-((3-fluoro-4-(trifluoromethoxy)benzyl)amino)butoxy)propan-2-yl)oxy)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 180 Casein kinase II subunit alpha [2-329] 0.180 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644585&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915258 490946917 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365100 C[C@H](COCCCCNCc1ccc(OC(F)(F)F)c(F)c1)Nc1nc2cc(ccc2c2cnccc12)C(O)=O InChI=1S/C28H28F4N4O4/c1-17(16-39-11-3-2-9-33-14-18-4-7-25(23(29)12-18)40-28(30,31)32)35-26-21-8-10-34-15-22(21)20-6-5-19(27(37)38)13-24(20)36-26/h4-8,10,12-13,15,17,33H,2-3,9,11,14,16H2,1H3,(H,35,36)(H,37,38)/t17-/m1/s1 QCTKFZKNAAEORA-QGZVFWFLSA-N 644586 (R)-5-((1-(4-((3-fluoro-4-(trifluoromethoxy)benzyl)amino)butoxy)propan-2-yl)amino)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 181 Casein kinase II subunit alpha [2-329] 0.428 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644586&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915129 490946918 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365102 C[C@H](COCCCCNCc1cc(F)c(OC(F)(F)F)c(F)c1)Nc1nc2cc(ccc2c2cnccc12)C(O)=O InChI=1S/C28H27F5N4O4/c1-16(36-26-20-6-8-35-14-21(20)19-5-4-18(27(38)39)12-24(19)37-26)15-40-9-3-2-7-34-13-17-10-22(29)25(23(30)11-17)41-28(31,32)33/h4-6,8,10-12,14,16,34H,2-3,7,9,13,15H2,1H3,(H,36,37)(H,38,39)/t16-/m1/s1 OYICKRPKZVEBNG-MRXNPFEDSA-N 644587 (R)-5-((1-(4-((3,5-difluoro-4-(trifluoromethoxy)benzyl)amino)butoxy)propan-2-yl)amino)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 182 Casein kinase II subunit alpha [2-329] 0.569 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644587&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915041 490946919 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1365104 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(F)c(OC(F)(F)F)c(F)c1)c1ccncc21 InChI=1S/C27H25F5N4O4/c28-21-11-16(12-22(29)24(21)40-27(30,31)32)14-34-6-1-2-8-38-9-10-39-26-19-5-7-35-15-20(19)18-4-3-17(25(33)37)13-23(18)36-26/h3-5,7,11-13,15,34H,1-2,6,8-10,14H2,(H2,33,37) CGNREXRCNHMWFS-UHFFFAOYSA-N 644588 5-(2-(4-((3,5-Difluoro-4-(trifluoromethoxy)benzyl)amino)butoxy)ethoxy)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 183 Casein kinase II subunit alpha [2-329] 1.77 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644588&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915101 490946920 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364740 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC3CCC3)c(CO)c1)c1ccncc21 InChI=1S/C31H37N5O4/c32-30(38)22-7-8-25-27-19-34-12-10-26(27)31(36-28(25)17-22)35-13-15-39-14-2-1-11-33-18-21-6-9-29(23(16-21)20-37)40-24-4-3-5-24/h6-10,12,16-17,19,24,33,37H,1-5,11,13-15,18,20H2,(H2,32,38)(H,35,36) TXRNQNXTDJJHAB-UHFFFAOYSA-N 644407 5-((2-(4-((4-cyclobutoxy-3-(hydroxymethyl)benzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 1 Casein kinase II subunit alpha [2-329] 0.425 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644407&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915167 490946740 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364742 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(c(Cl)c1)-c1ccccc1)c1ccncc21 InChI=1S/C32H32ClN5O2/c33-29-18-22(8-10-25(29)23-6-2-1-3-7-23)20-35-13-4-5-16-40-17-15-37-32-27-12-14-36-21-28(27)26-11-9-24(31(34)39)19-30(26)38-32/h1-3,6-12,14,18-19,21,35H,4-5,13,15-17,20H2,(H2,34,39)(H,37,38) JXVHFVDLYKIXHT-UHFFFAOYSA-N 644408 5-((2-(4-(((2-Chloro-[1,1′-biphenyl]-4-yl)methyl)amino)butoxy)ethyl)amino)benzo[c][2,6] naphthyridine-8-carboxamide::US11866436, Example 2 Casein kinase II subunit alpha [2-329] 0.306 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644408&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915120 490946741 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364744 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)c1ccncc21 InChI=1S/C27H27ClF3N5O3/c28-22-13-17(3-6-24(22)39-27(29,30)31)15-33-8-1-2-11-38-12-10-35-26-20-7-9-34-16-21(20)19-5-4-18(25(32)37)14-23(19)36-26/h3-7,9,13-14,16,33H,1-2,8,10-12,15H2,(H2,32,37)(H,35,36) KFSMADUCMQUOPB-UHFFFAOYSA-N 644409 5-((2-(4-((3-chloro- 4-(trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine-8- carboxamide::US11866436, Example 3 Casein kinase II subunit alpha [2-329] 0.298 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644409&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915267 490946742 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364746 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cccc(Cl)c1)c1ccncc21 InChI=1S/C26H28ClN5O2/c27-20-5-3-4-18(14-20)16-29-9-1-2-12-34-13-11-31-26-22-8-10-30-17-23(22)21-7-6-19(25(28)33)15-24(21)32-26/h3-8,10,14-15,17,29H,1-2,9,11-13,16H2,(H2,28,33)(H,31,32) ZCLCMLMHEMDXAK-UHFFFAOYSA-N 644410 5-((2-(4-((3- chlorobenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 4 Casein kinase II subunit alpha [2-329] 1.16 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644410&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915269 490946743 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364748 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC(F)(F)F)c(c1)C#N)c1ccncc21 InChI=1S/C28H27F3N6O3/c29-28(30,31)40-25-6-3-18(13-20(25)15-32)16-34-8-1-2-11-39-12-10-36-27-22-7-9-35-17-23(22)21-5-4-19(26(33)38)14-24(21)37-27/h3-7,9,13-14,17,34H,1-2,8,10-12,16H2,(H2,33,38)(H,36,37) JERLKLPWPKWELB-UHFFFAOYSA-N 644411 5-((2-(4-((3- cyano-4- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 5 Casein kinase II subunit alpha [2-329] 1.72 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644411&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915090 490946744 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364750 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(c(Cl)c1)-c1ccccc1CO)c1ccncc21 InChI=1S/C33H34ClN5O3/c34-30-17-22(7-9-26(30)25-6-2-1-5-24(25)21-40)19-36-12-3-4-15-42-16-14-38-33-28-11-13-37-20-29(28)27-10-8-23(32(35)41)18-31(27)39-33/h1-2,5-11,13,17-18,20,36,40H,3-4,12,14-16,19,21H2,(H2,35,41)(H,38,39) GNYQNJNQFYUQRV-UHFFFAOYSA-N 644412 5-((2-(4-(((2- chloro-2'- (hydroxymethyl)- [1,1'-biphenyl]- 4-yl)methyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 6 Casein kinase II subunit alpha [2-329] 0.378 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644412&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 169018119 490946745 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364752 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC(F)(F)F)c(F)c1)c1ccncc21 InChI=1S/C27H27F4N5O3/c28-22-13-17(3-6-24(22)39-27(29,30)31)15-33-8-1-2-11-38-12-10-35-26-20-7-9-34-16-21(20)19-5-4-18(25(32)37)14-23(19)36-26/h3-7,9,13-14,16,33H,1-2,8,10-12,15H2,(H2,32,37)(H,35,36) VNAJSIZEQWWMNK-UHFFFAOYSA-N 644413 5-((2-(4-((3-fluoro-4- (trifluoromethoxy) benzyl)amino)butoxy) ethyl)amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 7 Casein kinase II subunit alpha [2-329] 0.586 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644413&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914982 490946746 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364754 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(c(Cl)c1)C(F)(F)F)c1ccncc21 InChI=1S/C27H27ClF3N5O2/c28-23-13-17(3-6-22(23)27(29,30)31)15-33-8-1-2-11-38-12-10-35-26-20-7-9-34-16-21(20)19-5-4-18(25(32)37)14-24(19)36-26/h3-7,9,13-14,16,33H,1-2,8,10-12,15H2,(H2,32,37)(H,35,36) BXPGHMIGIJEWJO-UHFFFAOYSA-N 644414 5-((2-(4-((3-chloro-4- (trifluoromethyl)benzyl) amino)butoxy)ethyl) amino)benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 8 Casein kinase II subunit alpha [2-329] 0.862 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644414&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914967 490946747 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364756 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(C3CC3)c(Cl)c1)c1ccncc21 InChI=1S/C29H32ClN5O2/c30-26-15-19(3-7-22(26)20-4-5-20)17-32-10-1-2-13-37-14-12-34-29-24-9-11-33-18-25(24)23-8-6-21(28(31)36)16-27(23)35-29/h3,6-9,11,15-16,18,20,32H,1-2,4-5,10,12-14,17H2,(H2,31,36)(H,34,35) VPCMAPSJWQZILZ-UHFFFAOYSA-N 644415 5-((2-(4-((3-chloro-4- cyclopropylbenzyl) amino)butoxy)ethyl) amino)benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 9 Casein kinase II subunit alpha [2-329] 0.568 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644415&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915010 490946748 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364758 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC3CCC3)c(Cl)c1)c1ccncc21 InChI=1S/C30H34ClN5O3/c31-26-16-20(6-9-28(26)39-22-4-3-5-22)18-33-11-1-2-14-38-15-13-35-30-24-10-12-34-19-25(24)23-8-7-21(29(32)37)17-27(23)36-30/h6-10,12,16-17,19,22,33H,1-5,11,13-15,18H2,(H2,32,37)(H,35,36) SRKWBNXTMZQFGN-UHFFFAOYSA-N 644416 5-((2-(4-((3-chloro-4- cyclobutoxybenzyl) amino)butoxy)ethyl) amino)benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 10 Casein kinase II subunit alpha [2-329] 0.372 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644416&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915078 490946749 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364760 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC3CCCC3)c(Cl)c1)c1ccncc21 InChI=1S/C31H36ClN5O3/c32-27-17-21(7-10-29(27)40-23-5-1-2-6-23)19-34-12-3-4-15-39-16-14-36-31-25-11-13-35-20-26(25)24-9-8-22(30(33)38)18-28(24)37-31/h7-11,13,17-18,20,23,34H,1-6,12,14-16,19H2,(H2,33,38)(H,36,37) YMHQJLDBABXRTR-UHFFFAOYSA-N 644417 5-((2-(4-((3-chloro-4- (cyclopentyloxy) benzyl)amino) butoxy)ethyl) amino)benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 11 Casein kinase II subunit alpha [2-329] 0.244 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644417&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915062 490946750 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364762 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC3CC3)c(Cl)c1)c1ccncc21 InChI=1S/C29H32ClN5O3/c30-25-15-19(3-8-27(25)38-21-5-6-21)17-32-10-1-2-13-37-14-12-34-29-23-9-11-33-18-24(23)22-7-4-20(28(31)36)16-26(22)35-29/h3-4,7-9,11,15-16,18,21,32H,1-2,5-6,10,12-14,17H2,(H2,31,36)(H,34,35) DOXJZOCIJLRFLH-UHFFFAOYSA-N 644418 5-((2-(4-((3-chloro-4- cyclopropoxybenzyl) amino)butoxy)ethyl) amino)benzo)[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 12::US11866436, Example 13 Casein kinase II subunit alpha [2-329] 0.481 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644418&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914961 490946751 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364764 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC3CC3)c(Cl)c1)c1ccncc21 InChI=1S/C29H32ClN5O3/c30-25-15-19(3-8-27(25)38-21-5-6-21)17-32-10-1-2-13-37-14-12-34-29-23-9-11-33-18-24(23)22-7-4-20(28(31)36)16-26(22)35-29/h3-4,7-9,11,15-16,18,21,32H,1-2,5-6,10,12-14,17H2,(H2,31,36)(H,34,35) DOXJZOCIJLRFLH-UHFFFAOYSA-N 644418 5-((2-(4-((3-chloro-4- cyclopropoxybenzyl) amino)butoxy)ethyl) amino)benzo)[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 12::US11866436, Example 13 Casein kinase II subunit alpha [2-329] 0.635 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644418&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914961 490946751 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364766 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cccc(CCO)c1)c1ccncc21 InChI=1S/C28H33N5O3/c29-27(35)22-6-7-23-25-19-31-11-8-24(25)28(33-26(23)17-22)32-12-15-36-14-2-1-10-30-18-21-5-3-4-20(16-21)9-13-34/h3-8,11,16-17,19,30,34H,1-2,9-10,12-15,18H2,(H2,29,35)(H,32,33) MMLPNBPWALBLMY-UHFFFAOYSA-N 644420 5-((2-(4-((3-(2- hydroxyethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 14 Casein kinase II subunit alpha [2-329] 9.93 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644420&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915023 490946752 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364768 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)c1ccncc21 InChI=1S/C27H26ClF3N4O4/c28-22-13-17(3-6-24(22)39-27(29,30)31)15-32-8-1-2-11-38-12-10-34-25-20-7-9-33-16-21(20)19-5-4-18(26(36)37)14-23(19)35-25/h3-7,9,13-14,16,32H,1-2,8,10-12,15H2,(H,34,35)(H,36,37) MEGVZXPQKGWUAG-UHFFFAOYSA-N 644421 5-((2-(4-((3-Chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 15 Casein kinase II subunit alpha [2-329] 0.382 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644421&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915034 490946753 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364770 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)c1ccncc21 InChI=1S/C27H26ClF3N4O4/c28-22-13-17(3-6-24(22)39-27(29,30)31)15-33-8-1-2-10-37-11-12-38-26-20-7-9-34-16-21(20)19-5-4-18(25(32)36)14-23(19)35-26/h3-7,9,13-14,16,33H,1-2,8,10-12,15H2,(H2,32,36) GXJZKOZQRLCJNH-UHFFFAOYSA-N 644422 5-(2-(4-((3-chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)ethoxy)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 16 Casein kinase II subunit alpha [2-329] 0.806 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644422&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915298 490946754 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364772 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cccc(Cl)c1)c1ccncc21 InChI=1S/C26H27ClN4O3/c27-20-5-3-4-18(14-20)16-29-9-1-2-11-33-12-13-34-26-22-8-10-30-17-23(22)21-7-6-19(25(28)32)15-24(21)31-26/h3-8,10,14-15,17,29H,1-2,9,11-13,16H2,(H2,28,32) DTBNAWPAMVKNGW-UHFFFAOYSA-N 644423 5-(2-(4-((3-chlorobenzyl)amino)butoxy)ethoxy)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 17 Casein kinase II subunit alpha [2-329] 2.94 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644423&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915306 490946755 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364774 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(C3CC3)c(c1)C#N)c1ccncc21 InChI=1S/C30H32N6O2/c31-17-23-15-20(3-7-24(23)21-4-5-21)18-33-10-1-2-13-38-14-12-35-30-26-9-11-34-19-27(26)25-8-6-22(29(32)37)16-28(25)36-30/h3,6-9,11,15-16,19,21,33H,1-2,4-5,10,12-14,18H2,(H2,32,37)(H,35,36) PEODZJCJQQSEBQ-UHFFFAOYSA-N 644424 5-((2-(4-((3- cyano-4- cyclopropylbenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 18 Casein kinase II subunit alpha [2-329] 1.01 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644424&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915271 490946756 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364776 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cccc(OCCO)c1)c1ccncc21 InChI=1S/C28H33N5O4/c29-27(35)21-6-7-23-25-19-31-10-8-24(25)28(33-26(23)17-21)32-11-14-36-13-2-1-9-30-18-20-4-3-5-22(16-20)37-15-12-34/h3-8,10,16-17,19,30,34H,1-2,9,11-15,18H2,(H2,29,35)(H,32,33) VLKSMSSWBKRQJM-UHFFFAOYSA-N 644425 5-((2-(4-((3-(2- hydroxyethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 19 Casein kinase II subunit alpha [2-329] 6.25 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644425&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915201 490946757 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364778 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC3CCC3)c(c1)C#N)c1ccncc21 InChI=1S/C31H34N6O3/c32-18-23-16-21(6-9-29(23)40-24-4-3-5-24)19-34-11-1-2-14-39-15-13-36-31-26-10-12-35-20-27(26)25-8-7-22(30(33)38)17-28(25)37-31/h6-10,12,16-17,20,24,34H,1-5,11,13-15,19H2,(H2,33,38)(H,36,37) PWHUGOZQQCNCHC-UHFFFAOYSA-N 644426 5-((2-(4-((3- cyano-4- cyclobutoxy- benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 20 Casein kinase II subunit alpha [2-329] 0.278 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644426&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915180 490946758 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364780 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cccc(CC#N)c1)c1ccncc21 InChI=1S/C28H30N6O2/c29-10-8-20-4-3-5-21(16-20)18-31-11-1-2-14-36-15-13-33-28-24-9-12-32-19-25(24)23-7-6-22(27(30)35)17-26(23)34-28/h3-7,9,12,16-17,19,31H,1-2,8,11,13-15,18H2,(H2,30,35)(H,33,34) LWJOKYODNCRKJE-UHFFFAOYSA-N 644427 5-((2-(4-((3- (cyanomethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 21 Casein kinase II subunit alpha [2-329] 1.74 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644427&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915021 490946759 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364782 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cccc(CO)c1)c1ccncc21 InChI=1S/C27H31N5O3/c28-26(34)21-6-7-22-24-17-30-10-8-23(24)27(32-25(22)15-21)31-11-13-35-12-2-1-9-29-16-19-4-3-5-20(14-19)18-33/h3-8,10,14-15,17,29,33H,1-2,9,11-13,16,18H2,(H2,28,34)(H,31,32) SENBIRDCDAUEDS-UHFFFAOYSA-N 644428 5-((2-(4-((3- (hydroxymethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 22 Casein kinase II subunit alpha [2-329] 15.6 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644428&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915028 490946760 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364784 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC(F)(F)F)c(CO)c1)c1ccncc21 InChI=1S/C28H30F3N5O4/c29-28(30,31)40-25-6-3-18(13-20(25)17-37)15-33-8-1-2-11-39-12-10-35-27-22-7-9-34-16-23(22)21-5-4-19(26(32)38)14-24(21)36-27/h3-7,9,13-14,16,33,37H,1-2,8,10-12,15,17H2,(H2,32,38)(H,35,36) XAHUHHVYQNIPGA-UHFFFAOYSA-N 644429 5-((2-(4-((3- (hydroxymethyl)-4- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 23 Casein kinase II subunit alpha [2-329] 1.18 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644429&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915051 490946761 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364786 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(Cl)c(OCCO)c1)c1ccncc21 InChI=1S/C28H32ClN5O4/c29-24-6-3-19(15-26(24)38-14-11-35)17-31-8-1-2-12-37-13-10-33-28-22-7-9-32-18-23(22)21-5-4-20(27(30)36)16-25(21)34-28/h3-7,9,15-16,18,31,35H,1-2,8,10-14,17H2,(H2,30,36)(H,33,34) ZKXNFYMYWVRXFY-UHFFFAOYSA-N 644430 5-((2-(4-((4- chloro-3-(2- hydroxyethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 24 Casein kinase II subunit alpha [2-329] 10.00 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644430&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915173 490946762 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364788 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC3CCC3)c(Cl)c1)c1ccncc21 InChI=1S/C30H33ClN4O4/c31-26-16-20(6-9-28(26)39-22-4-3-5-22)18-32-11-1-2-14-38-15-13-34-29-24-10-12-33-19-25(24)23-8-7-21(30(36)37)17-27(23)35-29/h6-10,12,16-17,19,22,32H,1-5,11,13-15,18H2,(H,34,35)(H,36,37) XBOHQXULVSSBPU-UHFFFAOYSA-N 644431 5-((2-(4-((3-Chloro-4-cyclobutoxybenzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 25 Casein kinase II subunit alpha [2-329] 0.366 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644431&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915274 490946763 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364790 OCCOc1cccc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(O)=O)c1 InChI=1S/C28H32N4O5/c33-12-15-37-22-5-3-4-20(16-22)18-29-9-1-2-13-36-14-11-31-27-24-8-10-30-19-25(24)23-7-6-21(28(34)35)17-26(23)32-27/h3-8,10,16-17,19,29,33H,1-2,9,11-15,18H2,(H,31,32)(H,34,35) XDTNBUUASJMQJU-UHFFFAOYSA-N 644432 5-((2-(4-((3-(2- hydroxyethoxy) benzyl)amino) butoxy)ethyl)amino) benzo[c][2,6] naphthyridine-8- carboxylic acid::US11866436, Example 26 Casein kinase II subunit alpha [2-329] 0.553 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644432&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915243 490946764 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364792 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cccc(CC#N)c1)c1ccncc21 InChI=1S/C28H29N5O3/c29-10-8-20-4-3-5-21(16-20)18-30-11-1-2-14-36-15-13-32-27-24-9-12-31-19-25(24)23-7-6-22(28(34)35)17-26(23)33-27/h3-7,9,12,16-17,19,30H,1-2,8,11,13-15,18H2,(H,32,33)(H,34,35) ZLDBGXKKPKKVSH-UHFFFAOYSA-N 644433 5-((2-(4-((3- (cyanomethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 27 Casein kinase II subunit alpha [2-329] 0.459 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644433&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915106 490946765 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364794 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC(F)(F)F)c(F)c1)c1ccncc21 InChI=1S/C27H26F4N4O4/c28-22-13-17(3-6-24(22)39-27(29,30)31)15-32-8-1-2-11-38-12-10-34-25-20-7-9-33-16-21(20)19-5-4-18(26(36)37)14-23(19)35-25/h3-7,9,13-14,16,32H,1-2,8,10-12,15H2,(H,34,35)(H,36,37) ICVZNFCMFZXHJG-UHFFFAOYSA-N 644434 5-((2-(4-((3- fluoro-4- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 28 Casein kinase II subunit alpha [2-329] 0.346 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644434&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915245 490946766 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364796 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(C3CC3)c(CO)c1)c1ccncc21 InChI=1S/C30H35N5O3/c31-29(37)22-6-8-25-27-18-33-11-9-26(27)30(35-28(25)16-22)34-12-14-38-13-2-1-10-32-17-20-3-7-24(21-4-5-21)23(15-20)19-36/h3,6-9,11,15-16,18,21,32,36H,1-2,4-5,10,12-14,17,19H2,(H2,31,37)(H,34,35) PLGOHXQIORLFDQ-UHFFFAOYSA-N 644435 5-((2-(4-((4- cyclopropyl-3- (hydroxymethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 29 Casein kinase II subunit alpha [2-329] 7.20 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644435&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915024 490946767 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364798 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cccc(Cl)c1)c1ccncc21 InChI=1S/C26H27ClN4O3/c27-20-5-3-4-18(14-20)16-28-9-1-2-12-34-13-11-30-25-22-8-10-29-17-23(22)21-7-6-19(26(32)33)15-24(21)31-25/h3-8,10,14-15,17,28H,1-2,9,11-13,16H2,(H,30,31)(H,32,33) KVFJYXRZONDRPG-UHFFFAOYSA-N 644436 5-((2-(4-((3- chlorobenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 30 Casein kinase II subunit alpha [2-329] 0.518 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644436&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915179 490946768 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364800 OCc1cc(Cl)cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(O)=O)c1 InChI=1S/C27H29ClN4O4/c28-21-12-18(11-19(13-21)17-33)15-29-6-1-2-9-36-10-8-31-26-23-5-7-30-16-24(23)22-4-3-20(27(34)35)14-25(22)32-26/h3-5,7,11-14,16,29,33H,1-2,6,8-10,15,17H2,(H,31,32)(H,34,35) YVGAYXYYCJPQMU-UHFFFAOYSA-N 644437 5-((2-(4-((3- chloro-5- (hydroxymethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 31 Casein kinase II subunit alpha [2-329] 0.676 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644437&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915239 490946769 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364802 OCCc1cccc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(O)=O)c1 InChI=1S/C28H32N4O4/c33-13-9-20-4-3-5-21(16-20)18-29-10-1-2-14-36-15-12-31-27-24-8-11-30-19-25(24)23-7-6-22(28(34)35)17-26(23)32-27/h3-8,11,16-17,19,29,33H,1-2,9-10,12-15,18H2,(H,31,32)(H,34,35) UHOYRLSIJQWYQD-UHFFFAOYSA-N 644438 5-((2-(4-((3-(2- hydroxyethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 32 Casein kinase II subunit alpha [2-329] 0.920 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644438&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915136 490946770 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364804 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(C3CC3)c(Cl)c1)c1ccncc21 InChI=1S/C29H31ClN4O3/c30-26-15-19(3-7-22(26)20-4-5-20)17-31-10-1-2-13-37-14-12-33-28-24-9-11-32-18-25(24)23-8-6-21(29(35)36)16-27(23)34-28/h3,6-9,11,15-16,18,20,31H,1-2,4-5,10,12-14,17H2,(H,33,34)(H,35,36) PEVDNKUCOHNRTA-UHFFFAOYSA-N 644439 5-((2-(4-((3-Chloro-4-cyclopropylbenzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 33 Casein kinase II subunit alpha [2-329] 0.221 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644439&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915163 490946771 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364806 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC3CC3)c(Cl)c1)c1ccncc21 InChI=1S/C29H31ClN4O4/c30-25-15-19(3-8-27(25)38-21-5-6-21)17-31-10-1-2-13-37-14-12-33-28-23-9-11-32-18-24(23)22-7-4-20(29(35)36)16-26(22)34-28/h3-4,7-9,11,15-16,18,21,31H,1-2,5-6,10,12-14,17H2,(H,33,34)(H,35,36) BKBQCPCLHUADAX-UHFFFAOYSA-N 644440 5-((2-(4-((3-chloro-4- cyclopropoxybenzyl) amino)butoxy)ethyl) amino)benzo[c][2,6] naphthyridine-8- carboxylic acid::US11866436, Example 34 Casein kinase II subunit alpha [2-329] 0.248 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644440&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915149 490946772 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364808 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC(F)(F)F)c(OCCO)c1)c1ccncc21 InChI=1S/C29H32F3N5O5/c30-29(31,32)42-25-6-3-19(15-26(25)41-14-11-38)17-34-8-1-2-12-40-13-10-36-28-22-7-9-35-18-23(22)21-5-4-20(27(33)39)16-24(21)37-28/h3-7,9,15-16,18,34,38H,1-2,8,10-14,17H2,(H2,33,39)(H,36,37) BDXLFWRYNWEKIJ-UHFFFAOYSA-N 644441 5-((2-(4-((3-(2- hydroxyethoxy)-4- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 35 Casein kinase II subunit alpha [2-329] 3.02 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644441&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915219 490946773 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364810 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC3CCC3)c(OCCO)c1)c1ccncc21 InChI=1S/C32H39N5O5/c33-31(39)23-7-8-25-27-21-35-12-10-26(27)32(37-28(25)19-23)36-13-16-40-15-2-1-11-34-20-22-6-9-29(42-24-4-3-5-24)30(18-22)41-17-14-38/h6-10,12,18-19,21,24,34,38H,1-5,11,13-17,20H2,(H2,33,39)(H,36,37) JAZIYDSJLZUATD-UHFFFAOYSA-N 644442 5-((2-(4-((4- cyclobutoxy-3-(2- hydroxyethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 36 Casein kinase II subunit alpha [2-329] 0.820 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644442&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 169018113 490946774 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364812 OCc1cccc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(O)=O)c1 InChI=1S/C27H30N4O4/c32-18-20-5-3-4-19(14-20)16-28-9-1-2-12-35-13-11-30-26-23-8-10-29-17-24(23)22-7-6-21(27(33)34)15-25(22)31-26/h3-8,10,14-15,17,28,32H,1-2,9,11-13,16,18H2,(H,30,31)(H,33,34) RPAZCKZIZMEAIN-UHFFFAOYSA-N 644443 5-((2-(4-((3- (hydroxymethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 37 Casein kinase II subunit alpha [2-329] 0.436 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644443&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915047 490946775 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364814 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(c(OCCO)c1)C(F)(F)F)c1ccncc21 InChI=1S/C29H32F3N5O4/c30-29(31,32)24-6-3-19(15-26(24)41-14-11-38)17-34-8-1-2-12-40-13-10-36-28-22-7-9-35-18-23(22)21-5-4-20(27(33)39)16-25(21)37-28/h3-7,9,15-16,18,34,38H,1-2,8,10-14,17H2,(H2,33,39)(H,36,37) YBXDQHWBBSNETQ-UHFFFAOYSA-N 644444 5-((2-(4-((3-(2- hydroxyethoxy)- 4-(trifluoromethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 38 Casein kinase II subunit alpha [2-329] 9.46 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644444&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915118 490946776 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364816 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(C3CC3)c(c1)C#N)c1ccncc21 InChI=1S/C30H31N5O3/c31-17-23-15-20(3-7-24(23)21-4-5-21)18-32-10-1-2-13-38-14-12-34-29-26-9-11-33-19-27(26)25-8-6-22(30(36)37)16-28(25)35-29/h3,6-9,11,15-16,19,21,32H,1-2,4-5,10,12-14,18H2,(H,34,35)(H,36,37) UYTQWUKVIAOCJI-UHFFFAOYSA-N 644445 5-((2-(4-((3-cyano-4- cyclopropylbenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 39 Casein kinase II subunit alpha [2-329] 0.197 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644445&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915052 490946777 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364818 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(Cl)cc(CC#N)c1)c1ccncc21 InChI=1S/C28H29ClN6O2/c29-22-14-19(5-7-30)13-20(15-22)17-32-8-1-2-11-37-12-10-34-28-24-6-9-33-18-25(24)23-4-3-21(27(31)36)16-26(23)35-28/h3-4,6,9,13-16,18,32H,1-2,5,8,10-12,17H2,(H2,31,36)(H,34,35) BYOFCPSWTJCYNJ-UHFFFAOYSA-N 644446 5-((2-(4-((3-Chloro-5-(cyanomethyl)benzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 40 Casein kinase II subunit alpha [2-329] 0.403 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644446&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915121 490946778 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364820 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC3CCC3)c(c1)C#N)c1ccncc21 InChI=1S/C31H33N5O4/c32-18-23-16-21(6-9-29(23)40-24-4-3-5-24)19-33-11-1-2-14-39-15-13-35-30-26-10-12-34-20-27(26)25-8-7-22(31(37)38)17-28(25)36-30/h6-10,12,16-17,20,24,33H,1-5,11,13-15,19H2,(H,35,36)(H,37,38) MFWFIUOCHGFKKK-UHFFFAOYSA-N 644447 5-((2-(4-((3-cyano-4- cyclobutoxybenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 41 Casein kinase II subunit alpha [2-329] 0.145 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644447&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915292 490946779 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364822 OC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(Cl)cc(CC#N)c1)c1ccncc21 InChI=1S/C28H28ClN5O3/c29-22-14-19(5-7-30)13-20(15-22)17-31-8-1-2-11-37-12-10-33-27-24-6-9-32-18-25(24)23-4-3-21(28(35)36)16-26(23)34-27/h3-4,6,9,13-16,18,31H,1-2,5,8,10-12,17H2,(H,33,34)(H,35,36) NTDKLKYQUXISQG-UHFFFAOYSA-N 644448 5-((2-(4-((3-chloro- 5-(cyanomethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 42 Casein kinase II subunit alpha [2-329] 0.203 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644448&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914997 490946780 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364824 NCc1cc(Cl)cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)c1 InChI=1S/C27H31ClN6O2/c28-21-12-18(15-29)11-19(13-21)16-31-6-1-2-9-36-10-8-33-27-23-5-7-32-17-24(23)22-4-3-20(26(30)35)14-25(22)34-27/h3-5,7,11-14,17,31H,1-2,6,8-10,15-16,29H2,(H2,30,35)(H,33,34) LMLCQJNTDFFXBL-UHFFFAOYSA-N 644449 5-((2-(4-((3-(Aminomethyl)-5-chlorobenzyl)amino)butoxy)ethyl)amino)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 43 Casein kinase II subunit alpha [2-329] 5.71 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644449&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915175 490946781 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364826 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(Cl)cc(CC#N)c1)c1ccncc21 InChI=1S/C28H28ClN5O3/c29-22-14-19(5-7-30)13-20(15-22)17-32-8-1-2-10-36-11-12-37-28-24-6-9-33-18-25(24)23-4-3-21(27(31)35)16-26(23)34-28/h3-4,6,9,13-16,18,32H,1-2,5,8,10-12,17H2,(H2,31,35) NZIRTWSQGCVBRE-UHFFFAOYSA-N 644450 5-(2-(4-((3-Chloro-5-(cyanomethyl)benzyl)amino)butoxy)ethoxy)benzo[c][2,6]naphthyridine-8-carboxamide::US11866436, Example 44 Casein kinase II subunit alpha [2-329] 0.833 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644450&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915053 490946782 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364828 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1ccc(OC3CCC3)c(Cl)c1)c1ccncc21 InChI=1S/C30H33ClN4O4/c31-26-16-20(6-9-28(26)39-22-4-3-5-22)18-33-11-1-2-13-37-14-15-38-30-24-10-12-34-19-25(24)23-8-7-21(29(32)36)17-27(23)35-30/h6-10,12,16-17,19,22,33H,1-5,11,13-15,18H2,(H2,32,36) KXXOSVXRQOSRGY-UHFFFAOYSA-N 644451 5-(2-(4-((3- chloro-4- cyclobutoxy benzyl)amino) butoxy) ethoxy)benzo [c][2,6] naphthyridine-8- carboxamide::US11866436, Example 45 Casein kinase II subunit alpha [2-329] 0.760 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644451&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915241 490946783 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364830 OC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)c1ccncc21 InChI=1S/C27H25ClF3N3O5/c28-22-13-17(3-6-24(22)39-27(29,30)31)15-32-8-1-2-10-37-11-12-38-25-20-7-9-33-16-21(20)19-5-4-18(26(35)36)14-23(19)34-25/h3-7,9,13-14,16,32H,1-2,8,10-12,15H2,(H,35,36) ZXBOCEMSOANKPH-UHFFFAOYSA-N 644452 5-(2-(4-((3-Chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)ethoxy)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 46 Casein kinase II subunit alpha [2-329] 0.404 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644452&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915212 490946784 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364832 Cc1cc(CO)cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)c1 InChI=1S/C28H33N5O3/c1-19-12-20(14-21(13-19)18-34)16-30-7-2-3-10-36-11-9-32-28-24-6-8-31-17-25(24)23-5-4-22(27(29)35)15-26(23)33-28/h4-6,8,12-15,17,30,34H,2-3,7,9-11,16,18H2,1H3,(H2,29,35)(H,32,33) GQCAWHLYBCYTDM-UHFFFAOYSA-N 644453 5-((2-(4-((3- (hydroxymethyl)- 5-methylbenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 47 Casein kinase II subunit alpha [2-329] 3.08 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644453&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915268 490946785 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364834 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CO)cc(c1)C(F)(F)F)c1ccncc21 InChI=1S/C28H30F3N5O3/c29-28(30,31)21-12-18(11-19(13-21)17-37)15-33-6-1-2-9-39-10-8-35-27-23-5-7-34-16-24(23)22-4-3-20(26(32)38)14-25(22)36-27/h3-5,7,11-14,16,33,37H,1-2,6,8-10,15,17H2,(H2,32,38)(H,35,36) PSQFBYYCAIHWKL-UHFFFAOYSA-N 644454 5-((2-(4-((3- (hydroxymethyl)- 5-(trifluoromethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 48 Casein kinase II subunit alpha [2-329] 0.704 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644454&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915262 490946786 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364836 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(Cl)c(CO)c1)c1ccncc21 InChI=1S/C27H30ClN5O3/c28-24-6-3-18(13-20(24)17-34)15-30-8-1-2-11-36-12-10-32-27-22-7-9-31-16-23(22)21-5-4-19(26(29)35)14-25(21)33-27/h3-7,9,13-14,16,30,34H,1-2,8,10-12,15,17H2,(H2,29,35)(H,32,33) CHEAAIPINNRRKM-UHFFFAOYSA-N 644455 5-((2-(4-((4-chloro- 3-(hydroxymethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 49 Casein kinase II subunit alpha [2-329] 7.87 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644455&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915283 490946787 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364838 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1ccc(OC(F)(F)F)c(F)c1)c1ccncc21 InChI=1S/C27H26F4N4O4/c28-22-13-17(3-6-24(22)39-27(29,30)31)15-33-8-1-2-10-37-11-12-38-26-20-7-9-34-16-21(20)19-5-4-18(25(32)36)14-23(19)35-26/h3-7,9,13-14,16,33H,1-2,8,10-12,15H2,(H2,32,36) DTWCVKKTOYUKED-UHFFFAOYSA-N 644456 5-(2-(4-((3- fluoro-4-(trifluoromethoxy)benzyl)amino)butoxy)ethoxy)benzo[c][2, 6]naphthyridine-8-carboxamide::US11866436, Example 50 Casein kinase II subunit alpha [2-329] 1.31 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644456&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915279 490946788 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364840 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1ccc(C3CC3)c(c1)C#N)c1ccncc21 InChI=1S/C30H31N5O3/c31-17-23-15-20(3-7-24(23)21-4-5-21)18-33-10-1-2-12-37-13-14-38-30-26-9-11-34-19-27(26)25-8-6-22(29(32)36)16-28(25)35-30/h3,6-9,11,15-16,19,21,33H,1-2,4-5,10,12-14,18H2,(H2,32,36) CKDCFGNOHLPEKW-UHFFFAOYSA-N 644457 5-(2-(4-((3- cyano-4- cyclopropyl benzyl)amino) butoxy)ethoxy) benzo [c][2,6]naph- thyridine-8- carboxamide::US11866436, Example 51 Casein kinase II subunit alpha [2-329] 2.39 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644457&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914998 490946789 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364842 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1ccc(OC3CCC3)c(CO)c1)c1ccncc21 InChI=1S/C31H36N4O5/c32-30(37)22-7-8-25-27-19-34-12-10-26(27)31(35-28(25)17-22)39-15-14-38-13-2-1-11-33-18-21-6-9-29(23(16-21)20-36)40-24-4-3-5-24/h6-10,12,16-17,19,24,33,36H,1-5,11,13-15,18,20H2,(H2,32,37) RWVTZXUGRIUFJI-UHFFFAOYSA-N 644458 5-(2-(4-((4- cyclobutoxy- 3- (hydroxy- methyl)benzyl) amino)butoxy) ethoxy) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 52 Casein kinase II subunit alpha [2-329] 1.28 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644458&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164914964 490946790 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364844 NC(=O)c1ccc2c(c1)nc(OCCOCCCCNCc1cc(Cl)cc(CO)c1)c1ccncc21 InChI=1S/C27H29ClN4O4/c28-21-12-18(11-19(13-21)17-33)15-30-6-1-2-8-35-9-10-36-27-23-5-7-31-16-24(23)22-4-3-20(26(29)34)14-25(22)32-27/h3-5,7,11-14,16,30,33H,1-2,6,8-10,15,17H2,(H2,29,34) UZERBHWLKRWETL-UHFFFAOYSA-N 644459 5-(2-(4-((3- chloro-5- (hydroxy- methyl)benzyl) amino)butoxy) ethoxy) benzo[c][2,6] naphthyridine- 8- carboxamide::US11866436, Example 53 Casein kinase II subunit alpha [2-329] 1.16 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644459&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915139 490946791 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364846 OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1ccc(OC(F)(F)F)c(Cl)c1)c1ccncc21 InChI=1S/C28H26ClF3N4O4/c29-23-11-17(3-6-25(23)40-28(30,31)32)13-33-8-1-2-10-39-19-15-36(16-19)26-21-7-9-34-14-22(21)20-5-4-18(27(37)38)12-24(20)35-26/h3-7,9,11-12,14,19,33H,1-2,8,10,13,15-16H2,(H,37,38) KHQBJGWNPXLJQL-UHFFFAOYSA-N 644460 5-(3-(4-((3-Chloro-4-(trifluoromethoxy)benzyl)amino)butoxy)azetidin-1-yl)benzo[c][2,6]naphthyridine-8-carboxylic Acid::US11866436, Example 54 Casein kinase II subunit alpha [2-329] 0.688 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644460&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915217 490946792 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364848 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(F)cc(CO)c1)c1ccncc21 InChI=1S/C27H30FN5O3/c28-21-12-18(11-19(13-21)17-34)15-30-6-1-2-9-36-10-8-32-27-23-5-7-31-16-24(23)22-4-3-20(26(29)35)14-25(22)33-27/h3-5,7,11-14,16,30,34H,1-2,6,8-10,15,17H2,(H2,29,35)(H,32,33) NQBZANYXIXJZEH-UHFFFAOYSA-N 644461 5-((2-(4-((3-fluoro- 5-(hydroxymethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 55 Casein kinase II subunit alpha [2-329] 1.67 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644461&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915031 490946793 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364850 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CC#N)cc(c1)C(F)(F)F)c1ccncc21 InChI=1S/C29H29F3N6O2/c30-29(31,32)22-14-19(5-7-33)13-20(15-22)17-35-8-1-2-11-40-12-10-37-28-24-6-9-36-18-25(24)23-4-3-21(27(34)39)16-26(23)38-28/h3-4,6,9,13-16,18,35H,1-2,5,8,10-12,17H2,(H2,34,39)(H,37,38) OHEVVEJVQNXGHF-UHFFFAOYSA-N 644462 5-((2-(4-((3- (cyanomethyl)-5- (trifluoromethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 56 Casein kinase II subunit alpha [2-329] 0.427 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644462&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915004 490946794 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364852 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(F)cc(CC#N)c1)c1ccncc21 InChI=1S/C28H29FN6O2/c29-22-14-19(5-7-30)13-20(15-22)17-32-8-1-2-11-37-12-10-34-28-24-6-9-33-18-25(24)23-4-3-21(27(31)36)16-26(23)35-28/h3-4,6,9,13-16,18,32H,1-2,5,8,10-12,17H2,(H2,31,36)(H,34,35) YPQDLCCUCGHLEA-UHFFFAOYSA-N 644463 5-((2-(4-((3- (cyanomethyl)- 5-fluorobenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 57 Casein kinase II subunit alpha [2-329] 0.665 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644463&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915116 490946795 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364854 Cc1cc(CNCCCCOCCNc2nc3cc(ccc3c3cnccc23)C(N)=O)cc(CC#N)c1 InChI=1S/C29H32N6O2/c1-20-14-21(6-8-30)16-22(15-20)18-32-9-2-3-12-37-13-11-34-29-25-7-10-33-19-26(25)24-5-4-23(28(31)36)17-27(24)35-29/h4-5,7,10,14-17,19,32H,2-3,6,9,11-13,18H2,1H3,(H2,31,36)(H,34,35) KEJZNRXUODJMCY-UHFFFAOYSA-N 644464 5-((2-(4-((3- (cyanomethyl)- 5-methylbenzyl) amino)butoxy) ethyl)amino) benzo[c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 58 Casein kinase II subunit alpha [2-329] 0.638 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644464&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915057 490946796 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 1364856 NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(CC#N)ccc1Cl)c1ccncc21 InChI=1S/C28H29ClN6O2/c29-25-6-3-19(7-9-30)15-21(25)17-32-10-1-2-13-37-14-12-34-28-23-8-11-33-18-24(23)22-5-4-20(27(31)36)16-26(22)35-28/h3-6,8,11,15-16,18,32H,1-2,7,10,12-14,17H2,(H2,31,36)(H,34,35) JYCTXGSXDULZTJ-UHFFFAOYSA-N 644465 5-((2-(4-((2-chloro- 5-(cyanomethyl) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 59 Casein kinase II subunit alpha [2-329] 8.92 US Patent 10.7270/Q2WM1JKH US11866436 Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Cambridge Enterprise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=644465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1520&target=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=644465&enzyme=Casein+kinase+II+subunit+alpha+%5B2-329%5D&column=ki&startPg=0&Increment=50&submit=Search 164915284 490946797 1 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK