BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 32819 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 LXBIFEVIBLOUGU-JGWLITMVSA-N 18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US9181184, 1::dNM Lysosomal acid glucosylceramidase Homo sapiens 79000 240000 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DNJ 1DIE,1DOG,1I75,1OIM,2J77,2JKE,2PWD,3GBE,3GXT 29435 46518429 44369 CHEMBL307429 4642 C16843 ZINC03794714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32820 CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1 AAKDPDFZMNYDLR-XZBKPIIZSA-N 18353 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine-3,4,5-triol::CHEMBL75971::N-Methyl-DNJ::US9181184, 2 Lysosomal acid glucosylceramidase Homo sapiens 150000 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18353&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 92381 46518430 CHEMBL75971 ZINC03795332 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32821 CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C9H19NO4/c1-2-3-10-4-7(12)9(14)8(13)6(10)5-11/h6-9,11-14H,2-5H2,1H3/t6-,7+,8-,9-/m1/s1 DUKKBXHYYSHSAI-BZNPZCIMSA-N 18354 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-propylpiperidine-3,4,5-triol::N-Propyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 700000 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18354&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9815644 46518431 ZINC14967754 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32822 CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 UQRORFVVSGFNRO-UTINFBMNSA-N 18355 (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol::CHEMBL1029::MIGLUSTAT::N-Butyl-DNJ::US9181184, 5 Lysosomal acid glucosylceramidase Homo sapiens 116000 270000 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18355&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NBV 5IEF,2V3D 51634 46518432 50381 CHEMBL1029 DB00419 4841 ZINC03794711 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32823 CCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C12H25NO4/c1-2-3-4-5-6-13-7-10(15)12(17)11(16)9(13)8-14/h9-12,14-17H,2-8H2,1H3/t9-,10+,11-,12-/m1/s1 KRNOSIJCJVCXKU-WRWGMCAJSA-N 18356 (2R,3R,4R,5S)-1-hexyl-2-(hydroxymethyl)piperidine-3,4,5-triol::N-Hexyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 5500 13000 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18356&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 12766473 46518433 ZINC03799255 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32824 CCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C14H29NO4/c1-2-3-4-5-6-7-8-15-9-12(17)14(19)13(18)11(15)10-16/h11-14,16-19H,2-10H2,1H3/t11-,12+,13-,14-/m1/s1 VGSQNAQYXKTCLP-XJFOESAGSA-N 18357 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-3,4,5-triol::N-Octyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 420 820 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18357&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9882040 46518434 ZINC14967758 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32825 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 300 660 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32826 C[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C7H15NO4/c1-3-5(10)7(12)6(11)4(2-9)8-3/h3-12H,2H2,1H3/t3-,4-,5+,6-,7-/m1/s1 ZEWFPWKROPWRKE-XUUWZHRGSA-N 18359 (2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-methylpiperidine-3,4,5-triol::CHEMBL503021::alpha-1-C-Methyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 900000 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18359&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10921056 46518436 CHEMBL503021 ZINC14967762 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32827 CCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C9H19NO4/c1-2-3-5-7(12)9(14)8(13)6(4-11)10-5/h5-14H,2-4H2,1H3/t5-,6-,7+,8-,9-/m1/s1 WUPMYSMCQJMDRE-SYHAXYEDSA-N 18360 (2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-propylpiperidine-3,4,5-triol::alpha-1-C-Propyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 400000 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18360&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10932614 46518437 ZINC14967766 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32828 CCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C10H21NO4/c1-2-3-4-6-8(13)10(15)9(14)7(5-12)11-6/h6-15H,2-5H2,1H3/t6-,7-,8+,9-,10-/m1/s1 ZSNFEMNRWFDMNU-HOTMZDKISA-N 18361 (2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidine-3,4,5-triol::alpha-1-C-Butyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 110000 100000 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18361&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11009466 46518438 ZINC14967770 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32829 CCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C12H25NO4/c1-2-3-4-5-6-8-10(15)12(17)11(16)9(7-14)13-8/h8-17H,2-7H2,1H3/t8-,9-,10+,11-,12-/m1/s1 CNCWFVJLRHKDJX-RMPHRYRLSA-N 18362 (2R,3S,4R,5R,6R)-2-hexyl-6-(hydroxymethyl)piperidine-3,4,5-triol::alpha-1-C-Hexyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 2300 4200 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18362&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23647981 46518439 ZINC14967774 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32830 CCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C14H29NO4/c1-2-3-4-5-6-7-8-10-12(17)14(19)13(18)11(9-16)15-10/h10-19H,2-9H2,1H3/t10-,11-,12+,13-,14-/m1/s1 IIHXPVAHXKBRBL-RKQHYHRCSA-N 18363 (2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-octylpiperidine-3,4,5-triol::CO-DNJ::alpha-1-C-Octyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 280 500 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18363&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23647982 46518440 ZINC14967777 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32831 CCCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-11-13(18)15(20)14(19)12(10-17)16-11/h11-20H,2-10H2,1H3/t11-,12-,13+,14-,15-/m1/s1 PMSTUSHNMMAWCI-UXXRCYHCSA-N 18364 (2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-nonylpiperidine-3,4,5-triol::CN-DNJ::US9181184, 32::alpha-1-C-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 200 270 5.5 37.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.08.003 10.7270/Q2BZ649B 16919960 aid1797728 Yu, L; Ikeda, K; Kato, A; Adachi, I; Godin, G; Compain, P; Martin, O; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18364&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11150434 46518441 ZINC14967781 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32846 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)N1CCCC(=O)NC12CC3CC(CC(C3)C1)C2 InChI=1S/C20H34N2O5/c23-10-15-18(26)19(27)16(11-24)22(15)3-1-2-17(25)21-20-7-12-4-13(8-20)6-14(5-12)9-20/h12-16,18-19,23-24,26-27H,1-11H2,(H,21,25)/t12?,13?,14?,15-,16+,18-,19-,20?/m1/s1 FKAZMCXZKPHPIL-CYLNEKRHSA-N 18367 2,5-anhydro-2,5-imino-D-glucitol based compound, 1::N-(adamantan-1-yl)-4-[(2S,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)pyrrolidin-1-yl]butanamide Lysosomal acid glucosylceramidase Homo sapiens 507000 5 37.00 C Curated from the literature by BindingDB 10.1021/jm060677i 10.7270/Q2765CMC 17201413 aid1797729 Yu, Z; Sawkar, AR; Whalen, LJ; Wong, CH; Kelly, JW The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18367&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16100284 46518443 ZINC14967785 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32847 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)N1CCCCC(=O)NC12CC3CC(CC(C3)C1)C2 InChI=1S/C21H36N2O5/c24-11-16-19(27)20(28)17(12-25)23(16)4-2-1-3-18(26)22-21-8-13-5-14(9-21)7-15(6-13)10-21/h13-17,19-20,24-25,27-28H,1-12H2,(H,22,26)/t13?,14?,15?,16-,17+,19-,20-,21?/m1/s1 ZFCATLYSHYBNHN-AKBIMTTGSA-N 18368 2,5-anhydro-2,5-imino-D-glucitol based compound, 2::N-(adamantan-1-yl)-5-[(2S,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)pyrrolidin-1-yl]pentanamide Lysosomal acid glucosylceramidase Homo sapiens 393000 5 37.00 C Curated from the literature by BindingDB 10.1021/jm060677i 10.7270/Q2765CMC 17201413 aid1797729 Yu, Z; Sawkar, AR; Whalen, LJ; Wong, CH; Kelly, JW The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18368&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16100287 46518444 ZINC14967788 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32848 OC[C@H]1CN(CCCC(=O)NC23CC4CC(CC(C4)C2)C3)C[C@@H](O)[C@@H]1O InChI=1S/C20H34N2O4/c23-12-16-10-22(11-17(24)19(16)26)3-1-2-18(25)21-20-7-13-4-14(8-20)6-15(5-13)9-20/h13-17,19,23-24,26H,1-12H2,(H,21,25)/t13?,14?,15?,16-,17-,19-,20?/m1/s1 SOTQIIBUGHONKZ-WEUZRQAKSA-N 18369 N-(adamantan-1-yl)-4-[(3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)piperidin-1-yl]butanamide::isofagomine-based compound, 3 Lysosomal acid glucosylceramidase Homo sapiens 18000 5 37.00 C Curated from the literature by BindingDB 10.1021/jm060677i 10.7270/Q2765CMC 17201413 aid1797729 Yu, Z; Sawkar, AR; Whalen, LJ; Wong, CH; Kelly, JW The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18369&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16100285 46518445 ZINC14967791 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32849 OC[C@H]1CN(CCCCC(=O)NC23CC4CC(CC(C4)C2)C3)C[C@@H](O)[C@@H]1O InChI=1S/C21H36N2O4/c24-13-17-11-23(12-18(25)20(17)27)4-2-1-3-19(26)22-21-8-14-5-15(9-21)7-16(6-14)10-21/h14-18,20,24-25,27H,1-13H2,(H,22,26)/t14?,15?,16?,17-,18-,20-,21?/m1/s1 LYKNIHQMNRSKTH-JNEOLXESSA-N 18370 N-(adamantan-1-yl)-5-[(3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)piperidin-1-yl]pentanamide::isofagomine-based compound, 4 Lysosomal acid glucosylceramidase Homo sapiens 11000 5 37.00 C Curated from the literature by BindingDB 10.1021/jm060677i 10.7270/Q2765CMC 17201413 aid1797729 Yu, Z; Sawkar, AR; Whalen, LJ; Wong, CH; Kelly, JW The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18370&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16046245 46518446 ZINC14967795 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32850 OC[C@H]1CN(CCCCCC(=O)NC23CC4CC(CC(C4)C2)C3)C[C@@H](O)[C@@H]1O InChI=1S/C22H38N2O4/c25-14-18-12-24(13-19(26)21(18)28)5-3-1-2-4-20(27)23-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-19,21,25-26,28H,1-14H2,(H,23,27)/t15?,16?,17?,18-,19-,21-,22?/m1/s1 LQTZUNLDYXOQAC-FEXWWOSASA-N 18371 N-(adamantan-1-yl)-6-[(3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)piperidin-1-yl]hexanamide::isofagomine-based compound, 5 Lysosomal acid glucosylceramidase Homo sapiens 94000 5 37.00 C Curated from the literature by BindingDB 10.1021/jm060677i 10.7270/Q2765CMC 17201413 aid1797729 Yu, Z; Sawkar, AR; Whalen, LJ; Wong, CH; Kelly, JW The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18371&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16100286 46518447 ZINC14967799 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32907 Cc1cc(nc2ccc(NC(=O)C3CCCCC3)cc12)N1CCOCC1 InChI=1S/C21H27N3O2/c1-15-13-20(24-9-11-26-12-10-24)23-19-8-7-17(14-18(15)19)22-21(25)16-5-3-2-4-6-16/h7-8,13-14,16H,2-6,9-12H2,1H3,(H,22,25) BXVNPOBNVRBOOV-UHFFFAOYSA-N 18428 Aminoquinoline compound, 1::N-[4-methyl-2-(morpholin-4-yl)quinolin-6-yl]cyclohexanecarboxamide::NCGC00092410 Lysosomal acid glucosylceramidase Homo sapiens 21 31 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18428&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 5067281 46518503 ZINC03649803 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32908 CC1CCC(CC1)C(=O)Nc1ccc2nc(cc(C)c2c1)N1CCOCC1 InChI=1S/C22H29N3O2/c1-15-3-5-17(6-4-15)22(26)23-18-7-8-20-19(14-18)16(2)13-21(24-20)25-9-11-27-12-10-25/h7-8,13-15,17H,3-6,9-12H2,1-2H3,(H,23,26) COHPEUUUDGXEPG-UHFFFAOYSA-N 18430 4-methyl-N-[4-methyl-2-(morpholin-4-yl)quinolin-6-yl]cyclohexane-1-carboxamide::Aminoquinoline compound, 8::NCGC00045406 Lysosomal acid glucosylceramidase Homo sapiens 56 63 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18430&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3237927 46518504 ZINC03649839 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32909 CCCC1CCC(CC1)C(=O)Nc1ccc2nc(cc(C)c2c1)N1CCOCC1 InChI=1S/C24H33N3O2/c1-3-4-18-5-7-19(8-6-18)24(28)25-20-9-10-22-21(16-20)17(2)15-23(26-22)27-11-13-29-14-12-27/h9-10,15-16,18-19H,3-8,11-14H2,1-2H3,(H,25,28) OUDZANWEQJRFFQ-UHFFFAOYSA-N 18431 Aminoquinoline compound, 16::N-[4-methyl-2-(morpholin-4-yl)quinolin-6-yl]-4-propylcyclohexane-1-carboxamide Lysosomal acid glucosylceramidase Homo sapiens 55 133 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18431&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16759188 46518505 ZINC04563123 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32910 Cc1cc(nc2ccc(NC(=O)C3CC3)cc12)N1CCOCC1 InChI=1S/C18H21N3O2/c1-12-10-17(21-6-8-23-9-7-21)20-16-5-4-14(11-15(12)16)19-18(22)13-2-3-13/h4-5,10-11,13H,2-3,6-9H2,1H3,(H,19,22) PGJIKOYRDPOIMG-UHFFFAOYSA-N 18432 Aminoquinoline compound, 17::N-[4-methyl-2-(morpholin-4-yl)quinolin-6-yl]cyclopropanecarboxamide Lysosomal acid glucosylceramidase Homo sapiens 121 183 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18432&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16003777 46518506 ZINC08584253 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32911 CC1CCC(CC1)C(=O)Nc1ccc2nc(cc(C)c2c1)N1CCC(C)CC1 InChI=1S/C24H33N3O/c1-16-4-6-19(7-5-16)24(28)25-20-8-9-22-21(15-20)18(3)14-23(26-22)27-12-10-17(2)11-13-27/h8-9,14-17,19H,4-7,10-13H2,1-3H3,(H,25,28) LPXVCPVAKUZWGD-UHFFFAOYSA-N 18433 4-methyl-N-[4-methyl-2-(4-methylpiperidin-1-yl)quinolin-6-yl]cyclohexane-1-carboxamide::Aminoquinoline compound, 18 Lysosomal acid glucosylceramidase Homo sapiens 120 268 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18433&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 15999877 46518507 ZINC03894499 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32912 CC1CCC(CC1)C(=O)Nc1ccc2nc(cc(C)c2c1)N1CCCCC1 InChI=1S/C23H31N3O/c1-16-6-8-18(9-7-16)23(27)24-19-10-11-21-20(15-19)17(2)14-22(25-21)26-12-4-3-5-13-26/h10-11,14-16,18H,3-9,12-13H2,1-2H3,(H,24,27) RPWUBFVSFLXRCB-UHFFFAOYSA-N 18434 4-methyl-N-[4-methyl-2-(piperidin-1-yl)quinolin-6-yl]cyclohexane-1-carboxamide::Aminoquinoline compound, 19 Lysosomal acid glucosylceramidase Homo sapiens 184 452 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18434&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16002169 46518508 ZINC03648819 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32913 CCN(CC)c1cc(C)c2cc(NC(=O)C3CCC(C)CC3)ccc2n1 InChI=1S/C22H31N3O/c1-5-25(6-2)21-13-16(4)19-14-18(11-12-20(19)24-21)23-22(26)17-9-7-15(3)8-10-17/h11-15,17H,5-10H2,1-4H3,(H,23,26) PHNMAUWYEMWSDZ-UHFFFAOYSA-N 18435 Aminoquinoline compound, 20::N-[2-(diethylamino)-4-methylquinolin-6-yl]-4-methylcyclohexane-1-carboxamide Lysosomal acid glucosylceramidase Homo sapiens 514 1060 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18435&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16759189 46518509 ZINC03894450 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32914 CC1CCC(CC1)C(=O)Nc1ccc2nc(cc(C)c2c1)N1CCN(CC1)c1ncccn1 InChI=1S/C26H32N6O/c1-18-4-6-20(7-5-18)25(33)29-21-8-9-23-22(17-21)19(2)16-24(30-23)31-12-14-32(15-13-31)26-27-10-3-11-28-26/h3,8-11,16-18,20H,4-7,12-15H2,1-2H3,(H,29,33) GDSJFNUFUQXAIP-UHFFFAOYSA-N 18436 4-methyl-N-{4-methyl-2-[4-(pyrimidin-2-yl)piperazin-1-yl]quinolin-6-yl}cyclohexane-1-carboxamide::Aminoquinoline compound, 21 Lysosomal acid glucosylceramidase Homo sapiens 975 2450 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18436&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4244680 46518510 ZINC03650178 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32915 CC1CCC(CC1)C(=O)Nc1ccc2nc(Nc3cccc(Cl)c3)cc(C)c2c1 InChI=1S/C24H26ClN3O/c1-15-6-8-17(9-7-15)24(29)27-20-10-11-22-21(14-20)16(2)12-23(28-22)26-19-5-3-4-18(25)13-19/h3-5,10-15,17H,6-9H2,1-2H3,(H,26,28)(H,27,29) MVXXUSSYNJCXBF-UHFFFAOYSA-N 18437 Aminoquinoline compound, 22::N-{2-[(3-chlorophenyl)amino]-4-methylquinolin-6-yl}-4-methylcyclohexane-1-carboxamide Lysosomal acid glucosylceramidase Homo sapiens 122000 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18437&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16759190 46518511 ZINC06899663 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32916 CCc1nnc(NC(=O)c2ccc(NS(=O)(=O)c3ccccc3)cc2)s1 InChI=1S/C17H16N4O3S2/c1-2-15-19-20-17(25-15)18-16(22)12-8-10-13(11-9-12)21-26(23,24)14-6-4-3-5-7-14/h3-11,21H,2H2,1H3,(H,18,20,22) YMGXUJCEBOCIIT-UHFFFAOYSA-N 18438 4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamide::NCGC00060210::Sulfonamide analogue, 2 Lysosomal acid glucosylceramidase Homo sapiens 52 103 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18438&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2210290 46518512 ZINC06267373 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32917 Cc1cc(NC(=O)c2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2)no1 InChI=1S/C18H17N3O4S/c1-12-3-9-16(10-4-12)26(23,24)21-15-7-5-14(6-8-15)18(22)19-17-11-13(2)25-20-17/h3-11,21H,1-2H3,(H,19,20,22) NPAUELDNSYIBKW-UHFFFAOYSA-N 18439 N-(5-methyl-1,2-oxazol-3-yl)-4-[(4-methylbenzene)sulfonamido]benzamide::NCGC00058635::Sulfonamide analogue, 10 Lysosomal acid glucosylceramidase Homo sapiens 102 168 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18439&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1300581 46518513 ZINC01124348 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32918 CCCCNC(=O)c1ccc(NS(=O)(=O)c2ccccc2)cc1 InChI=1S/C17H20N2O3S/c1-2-3-13-18-17(20)14-9-11-15(12-10-14)19-23(21,22)16-7-5-4-6-8-16/h4-12,19H,2-3,13H2,1H3,(H,18,20) KAKHSUSGOXHWSK-UHFFFAOYSA-N 18440 4-benzenesulfonamido-N-butylbenzamide::Sulfonamide analogue, 11 Lysosomal acid glucosylceramidase Homo sapiens 7150 24600 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18440&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2224401 46518514 ZINC06244051 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32919 CCc1nnc(NC(=O)c2ccc(cc2)N(C)S(=O)(=O)c2ccccc2)s1 InChI=1S/C18H18N4O3S2/c1-3-16-20-21-18(26-16)19-17(23)13-9-11-14(12-10-13)22(2)27(24,25)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3,(H,19,21,23) MPDJPMXCUKNYCN-UHFFFAOYSA-N 18441 4-[benzene(methyl)sulfonamido]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamide::Sulfonamide analogue, 12 Lysosomal acid glucosylceramidase Homo sapiens 8440 2960 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18441&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1309961 46518515 ZINC01135954 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32920 CN(c1ccc(cc1)C(=O)Nc1cc(C)on1)S(=O)(=O)c1ccccc1 InChI=1S/C18H17N3O4S/c1-13-12-17(20-25-13)19-18(22)14-8-10-15(11-9-14)21(2)26(23,24)16-6-4-3-5-7-16/h3-12H,1-2H3,(H,19,20,22) RBQWPZZOSRJEKA-UHFFFAOYSA-N 18442 4-[benzene(methyl)sulfonamido]-N-(5-methyl-1,2-oxazol-3-yl)benzamide::Sulfonamide analogue, 13 Lysosomal acid glucosylceramidase Homo sapiens 19200 25200 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18442&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1310191 46518516 ZINC01136262 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32921 Clc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C(=O)Nc1nccs1 InChI=1S/C16H12ClN3O3S2/c17-12-3-7-14(8-4-12)25(22,23)20-13-5-1-11(2-6-13)15(21)19-16-18-9-10-24-16/h1-10,20H,(H,18,19,21) SFYMNLHZBPJJCB-UHFFFAOYSA-N 18443 4-[(4-chlorobenzene)sulfonamido]-N-(1,3-thiazol-2-yl)benzamide::Sulfonamide analogue, 23 Lysosomal acid glucosylceramidase Homo sapiens 556 1290 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18443&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1336667 46518517 ZINC01170762 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32922 CN(c1ccc(cc1)C(=O)Nc1nccs1)S(=O)(=O)c1ccccc1 InChI=1S/C17H15N3O3S2/c1-20(25(22,23)15-5-3-2-4-6-15)14-9-7-13(8-10-14)16(21)19-17-18-11-12-24-17/h2-12H,1H3,(H,18,19,21) LJZYYSIPPKMYER-UHFFFAOYSA-N 18444 4-[benzene(methyl)sulfonamido]-N-(1,3-thiazol-2-yl)benzamide::Sulfonamide analogue, 24::cid_1309992 Lysosomal acid glucosylceramidase Homo sapiens 23400 34400 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18444&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1309992 46518518 ZINC01135999 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32923 O=C(Nc1ccccc1)c1ccc(NS(=O)(=O)c2ccccc2)cc1 InChI=1S/C19H16N2O3S/c22-19(20-16-7-3-1-4-8-16)15-11-13-17(14-12-15)21-25(23,24)18-9-5-2-6-10-18/h1-14,21H,(H,20,22) IGYOTQOUZCVQGH-UHFFFAOYSA-N 18445 4-benzenesulfonamido-N-phenylbenzamide::Sulfonamide analogue, 25 Lysosomal acid glucosylceramidase Homo sapiens 13400 6460 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18445&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1362627 46518519 ZINC01205976 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32924 O=C(NCc1ccccc1)c1ccc(NS(=O)(=O)c2ccccc2)cc1 InChI=1S/C20H18N2O3S/c23-20(21-15-16-7-3-1-4-8-16)17-11-13-18(14-12-17)22-26(24,25)19-9-5-2-6-10-19/h1-14,22H,15H2,(H,21,23) VOKGLVVIZQMQNF-UHFFFAOYSA-N 18446 4-benzenesulfonamido-N-benzylbenzamide::Sulfonamide analogue, 26 Lysosomal acid glucosylceramidase Homo sapiens 50600 >100000 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18446&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1241968 46518520 ZINC01049409 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32925 COc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCC1 InChI=1S/C16H21ClN6O2/c1-25-13-5-4-11(17)10-12(13)19-15-20-14(18-6-9-24)21-16(22-15)23-7-2-3-8-23/h4-5,10,24H,2-3,6-9H2,1H3,(H2,18,19,20,21,22) AQYDNGDNBIIYOX-UHFFFAOYSA-N 18447 2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::NCGC00029010::Triazine compound, 3::triazine scaffold, 1 Lysosomal acid glucosylceramidase Homo sapiens 320 430 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18447&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 650378 46518521 ZINC04400045 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32926 Cc1cccc(Nc2nc(NCCO)nc(n2)N2CCCC2)c1 InChI=1S/C16H22N6O/c1-12-5-4-6-13(11-12)18-15-19-14(17-7-10-23)20-16(21-15)22-8-2-3-9-22/h4-6,11,23H,2-3,7-10H2,1H3,(H2,17,18,19,20,21) DSLSXSSYABXXSB-UHFFFAOYSA-N 18448 2-({4-[(3-methylphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::Triazine compound, 27::triazine scaffold, 26 Lysosomal acid glucosylceramidase Homo sapiens 2780 4310 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18448&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3146158 46518522 ZINC03625134 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32927 OCCNc1nc(Nc2ccc(Cl)cc2)nc(n1)N1CCCC1 InChI=1S/C15H19ClN6O/c16-11-3-5-12(6-4-11)18-14-19-13(17-7-10-23)20-15(21-14)22-8-1-2-9-22/h3-6,23H,1-2,7-10H2,(H2,17,18,19,20,21) XDVVBLXWYYYPSQ-UHFFFAOYSA-N 18449 2-({4-[(4-chlorophenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::Triazine compound, 28::triazine scaffold, 30 Lysosomal acid glucosylceramidase Homo sapiens 4230 7730 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18449&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2055451 46518523 ZINC02479533 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32928 Cc1cccc(Nc2nc(NCCO)nc(n2)N2CCOCC2)c1 InChI=1S/C16H22N6O2/c1-12-3-2-4-13(11-12)18-15-19-14(17-5-8-23)20-16(21-15)22-6-9-24-10-7-22/h2-4,11,23H,5-10H2,1H3,(H2,17,18,19,20,21) HWSDEDHTXCICDP-UHFFFAOYSA-N 18450 2-({4-[(3-methylphenyl)amino]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::Triazine compound, 29 Lysosomal acid glucosylceramidase Homo sapiens 47700 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18450&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3141863 46518524 ZINC05007269 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32929 OCCNc1nc(Nc2ccc(Cl)cc2)nc(n1)N1CCOCC1 InChI=1S/C15H19ClN6O2/c16-11-1-3-12(4-2-11)18-14-19-13(17-5-8-23)20-15(21-14)22-6-9-24-10-7-22/h1-4,23H,5-10H2,(H2,17,18,19,20,21) RLTOZUBSQJGNAU-UHFFFAOYSA-N 18451 2-({4-[(4-chlorophenyl)amino]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::Triazine compound, 30 Lysosomal acid glucosylceramidase Homo sapiens 46500 5.9 21.00 C Curated from the literature by BindingDB 10.1073/pnas.0705637104 10.7270/Q2V1232M 17670938 aid1797733 Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18451&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3141864 46518525 ZINC02924883 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32930 COc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCC1 InChI=1S/C16H21ClN6O2/c1-25-13-5-4-11(17)10-12(13)19-15-20-14(18-6-9-24)21-16(22-15)23-7-2-3-8-23/h4-5,10,24H,2-3,6-9H2,1H3,(H2,18,19,20,21,22) AQYDNGDNBIIYOX-UHFFFAOYSA-N 18447 2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::NCGC00029010::Triazine compound, 3::triazine scaffold, 1 Lysosomal acid glucosylceramidase Homo sapiens 700 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18447&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 650378 46518521 ZINC04400045 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32931 CCCCNc1nc(Nc2cc(Cl)ccc2OC)nc(n1)N1CCCC1 InChI=1S/C18H25ClN6O/c1-3-4-9-20-16-22-17(24-18(23-16)25-10-5-6-11-25)21-14-12-13(19)7-8-15(14)26-2/h7-8,12H,3-6,9-11H2,1-2H3,(H2,20,21,22,23,24) WFRPIZTYTLAABQ-UHFFFAOYSA-N 18452 2-N-butyl-4-N-(5-chloro-2-methoxyphenyl)-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamine::triazine scaffold, 7 Lysosomal acid glucosylceramidase Homo sapiens 7770 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18452&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648009 46518526 ZINC14968024 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32932 COc1ccccc1Nc1nc(NCC(C)O)nc(n1)N1CCCC1 InChI=1S/C17H24N6O2/c1-12(24)11-18-15-20-16(19-13-7-3-4-8-14(13)25-2)22-17(21-15)23-9-5-6-10-23/h3-4,7-8,12,24H,5-6,9-11H2,1-2H3,(H2,18,19,20,21,22) LEFTURAFKSDISD-UHFFFAOYSA-N 18453 1-({4-[(2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)propan-2-ol::triazine scaffold, 12 Lysosomal acid glucosylceramidase Homo sapiens 20700 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18453&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648010 46518527 ZINC14968032 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32933 COc1ccccc1Nc1nc(NCC(O)Cc2ccccc2)nc(n1)N1CCCC1 InChI=1S/C23H28N6O2/c1-31-20-12-6-5-11-19(20)25-22-26-21(27-23(28-22)29-13-7-8-14-29)24-16-18(30)15-17-9-3-2-4-10-17/h2-6,9-12,18,30H,7-8,13-16H2,1H3,(H2,24,25,26,27,28) YLPUAACXXUUVQP-UHFFFAOYSA-N 18454 1-({4-[(2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)-3-phenylpropan-2-ol::triazine scaffold, 13 Lysosomal acid glucosylceramidase Homo sapiens 6800 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18454&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648011 46518528 ZINC14968039 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32934 COc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCOCC1 InChI=1S/C16H21ClN6O3/c1-25-13-3-2-11(17)10-12(13)19-15-20-14(18-4-7-24)21-16(22-15)23-5-8-26-9-6-23/h2-3,10,24H,4-9H2,1H3,(H2,18,19,20,21,22) PUICQVMUQPJIFY-UHFFFAOYSA-N 18455 2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 17 Lysosomal acid glucosylceramidase Homo sapiens 12130 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18455&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3146886 46518529 ZINC05027565 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32935 COc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCCC1 InChI=1S/C17H23ClN6O2/c1-26-14-6-5-12(18)11-13(14)20-16-21-15(19-7-10-25)22-17(23-16)24-8-3-2-4-9-24/h5-6,11,25H,2-4,7-10H2,1H3,(H2,19,20,21,22,23) ZMPSLQHVIXWVTO-UHFFFAOYSA-N 18456 2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(piperidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::cid_23648012::triazine scaffold, 19 Lysosomal acid glucosylceramidase Homo sapiens 31100 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18456&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648012 46518530 ZINC12726133 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32936 CCCCNc1nc(NCCO)nc(Nc2ccccc2OC)n1 InChI=1S/C16H24N6O2/c1-3-4-9-17-14-20-15(18-10-11-23)22-16(21-14)19-12-7-5-6-8-13(12)24-2/h5-8,23H,3-4,9-11H2,1-2H3,(H3,17,18,19,20,21,22) DWTQAMUCUCTLIA-UHFFFAOYSA-N 18457 2-{[4-(butylamino)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino}ethan-1-ol::triazine scaffold, 21 Lysosomal acid glucosylceramidase Homo sapiens 6100 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18457&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648013 46518531 ZINC14968044 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32937 COc1ccccc1Nc1nc(NCCO)nc(NCc2ccccc2)n1 InChI=1S/C19H22N6O2/c1-27-16-10-6-5-9-15(16)22-19-24-17(20-11-12-26)23-18(25-19)21-13-14-7-3-2-4-8-14/h2-10,26H,11-13H2,1H3,(H3,20,21,22,23,24,25) DTQBPPDWCDHMOI-UHFFFAOYSA-N 18458 2-{[4-(benzylamino)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino}ethan-1-ol::triazine scaffold, 22 Lysosomal acid glucosylceramidase Homo sapiens 18800 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18458&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648014 46518532 ZINC14968047 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32938 COc1ccccc1Nc1nc(NCCO)nc(n1)N1CCC(F)(F)C1 InChI=1S/C16H20F2N6O2/c1-26-12-5-3-2-4-11(12)20-14-21-13(19-7-9-25)22-15(23-14)24-8-6-16(17,18)10-24/h2-5,25H,6-10H2,1H3,(H2,19,20,21,22,23) BBXZEECKMNPTIO-UHFFFAOYSA-N 18459 2-{[4-(3,3-difluoropyrrolidin-1-yl)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino}ethan-1-ol::triazine scaffold, 23 Lysosomal acid glucosylceramidase Homo sapiens 7750 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18459&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648015 46518533 ZINC14968050 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32939 COc1ccccc1Nc1nc(NCCO)nc(n1)N1CCC1 InChI=1S/C15H20N6O2/c1-23-12-6-3-2-5-11(12)17-14-18-13(16-7-10-22)19-15(20-14)21-8-4-9-21/h2-3,5-6,22H,4,7-10H2,1H3,(H2,16,17,18,19,20) XOSQDTKJROFJAM-UHFFFAOYSA-N 18460 2-{[4-(azetidin-1-yl)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino}ethan-1-ol::triazine scaffold, 24 Lysosomal acid glucosylceramidase Homo sapiens 2310 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18460&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648016 46518534 ZINC14968054 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32940 Cc1ccccc1Nc1nc(NCCO)nc(n1)N1CCCC1 InChI=1S/C16H22N6O/c1-12-6-2-3-7-13(12)18-15-19-14(17-8-11-23)20-16(21-15)22-9-4-5-10-22/h2-3,6-7,23H,4-5,8-11H2,1H3,(H2,17,18,19,20,21) KKJWZAHKIMVCSB-UHFFFAOYSA-N 18461 2-({4-[(2-methylphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 25 Lysosomal acid glucosylceramidase Homo sapiens 3940 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18461&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648017 46518535 ZINC14968058 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32942 Cc1ccc(Nc2nc(NCCO)nc(n2)N2CCCC2)cc1 InChI=1S/C16H22N6O/c1-12-4-6-13(7-5-12)18-15-19-14(17-8-11-23)20-16(21-15)22-9-2-3-10-22/h4-7,23H,2-3,8-11H2,1H3,(H2,17,18,19,20,21) YLHGSJGDPZGZRM-UHFFFAOYSA-N 18462 2-({4-[(4-methylphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 27 Lysosomal acid glucosylceramidase Homo sapiens 10040 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18462&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648018 46518536 ZINC12509046 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32943 OCCNc1nc(Nc2ccccc2Cl)nc(n1)N1CCCC1 InChI=1S/C15H19ClN6O/c16-11-5-1-2-6-12(11)18-14-19-13(17-7-10-23)20-15(21-14)22-8-3-4-9-22/h1-2,5-6,23H,3-4,7-10H2,(H2,17,18,19,20,21) GQGYXQXENCTJDT-UHFFFAOYSA-N 18463 2-({4-[(2-chlorophenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 28 Lysosomal acid glucosylceramidase Homo sapiens 28970 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18463&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648019 46518537 ZINC12726129 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32944 OCCNc1nc(Nc2cccc(Cl)c2)nc(n1)N1CCCC1 InChI=1S/C15H19ClN6O/c16-11-4-3-5-12(10-11)18-14-19-13(17-6-9-23)20-15(21-14)22-7-1-2-8-22/h3-5,10,23H,1-2,6-9H2,(H2,17,18,19,20,21) YGWBHVPEPQIPHJ-UHFFFAOYSA-N 18464 2-({4-[(3-chlorophenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 29 Lysosomal acid glucosylceramidase Homo sapiens 6690 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18464&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648020 46518538 ZINC14968062 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32945 OCCNc1nc(Nc2ccc(Cl)cc2)nc(n1)N1CCCC1 InChI=1S/C15H19ClN6O/c16-11-3-5-12(6-4-11)18-14-19-13(17-7-10-23)20-15(21-14)22-8-1-2-9-22/h3-6,23H,1-2,7-10H2,(H2,17,18,19,20,21) XDVVBLXWYYYPSQ-UHFFFAOYSA-N 18449 2-({4-[(4-chlorophenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::Triazine compound, 28::triazine scaffold, 30 Lysosomal acid glucosylceramidase Homo sapiens 6340 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18449&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2055451 46518523 ZINC02479533 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32946 COc1ccccc1Nc1nc(NCCO)nc(n1)N1CCCC1 InChI=1S/C16H22N6O2/c1-24-13-7-3-2-6-12(13)18-15-19-14(17-8-11-23)20-16(21-15)22-9-4-5-10-22/h2-3,6-7,23H,4-5,8-11H2,1H3,(H2,17,18,19,20,21) SZSULZUPSWDMKP-UHFFFAOYSA-N 18465 2-({4-[(2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 31 Lysosomal acid glucosylceramidase Homo sapiens 1080 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18465&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648021 46518539 ZINC12509042 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32947 COc1cccc(Nc2nc(NCCO)nc(n2)N2CCCC2)c1 InChI=1S/C16H22N6O2/c1-24-13-6-4-5-12(11-13)18-15-19-14(17-7-10-23)20-16(21-15)22-8-2-3-9-22/h4-6,11,23H,2-3,7-10H2,1H3,(H2,17,18,19,20,21) ZWMFEPYFXMGRTF-UHFFFAOYSA-N 18466 2-({4-[(3-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 32 Lysosomal acid glucosylceramidase Homo sapiens 8250 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18466&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648022 46518540 ZINC12509036 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32948 COc1ccc(Nc2nc(NCCO)nc(n2)N2CCCC2)cc1 InChI=1S/C16H22N6O2/c1-24-13-6-4-12(5-7-13)18-15-19-14(17-8-11-23)20-16(21-15)22-9-2-3-10-22/h4-7,23H,2-3,8-11H2,1H3,(H2,17,18,19,20,21) QDGWCTLLQIUYEH-UHFFFAOYSA-N 18467 2-({4-[(4-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 33 Lysosomal acid glucosylceramidase Homo sapiens 8800 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18467&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648023 46518541 ZINC12509029 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32949 OCCNc1nc(Nc2ccccc2O)nc(n1)N1CCCC1 InChI=1S/C15H20N6O2/c22-10-7-16-13-18-14(17-11-5-1-2-6-12(11)23)20-15(19-13)21-8-3-4-9-21/h1-2,5-6,22-23H,3-4,7-10H2,(H2,16,17,18,19,20) HPGFONOOSSVFJJ-UHFFFAOYSA-N 18468 2-({4-[(2-hydroxyethyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)phenol::triazine scaffold, 34 Lysosomal acid glucosylceramidase Homo sapiens 2000 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18468&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648024 46518542 ZINC12509019 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32950 CCOc1ccccc1Nc1nc(NCCO)nc(n1)N1CCCC1 InChI=1S/C17H24N6O2/c1-2-25-14-8-4-3-7-13(14)19-16-20-15(18-9-12-24)21-17(22-16)23-10-5-6-11-23/h3-4,7-8,24H,2,5-6,9-12H2,1H3,(H2,18,19,20,21,22) BKIZPCXJZRNQDH-UHFFFAOYSA-N 18469 2-({4-[(2-ethoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 35 Lysosomal acid glucosylceramidase Homo sapiens 770 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18469&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648025 46518543 ZINC14968066 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32951 OCCNc1nc(Nc2ccccc2Oc2ccccc2)nc(n1)N1CCCC1 InChI=1S/C21H24N6O2/c28-15-12-22-19-24-20(26-21(25-19)27-13-6-7-14-27)23-17-10-4-5-11-18(17)29-16-8-2-1-3-9-16/h1-5,8-11,28H,6-7,12-15H2,(H2,22,23,24,25,26) SOJHGFJRAQRFOT-UHFFFAOYSA-N 18470 2-({4-[(2-phenoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 36 Lysosomal acid glucosylceramidase Homo sapiens 21670 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18470&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648026 46518544 ZINC12509011 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32952 CC(C)(C)Oc1ccccc1Nc1nc(NCCO)nc(n1)N1CCCC1 InChI=1S/C19H28N6O2/c1-19(2,3)27-15-9-5-4-8-14(15)21-17-22-16(20-10-13-26)23-18(24-17)25-11-6-7-12-25/h4-5,8-9,26H,6-7,10-13H2,1-3H3,(H2,20,21,22,23,24) YLYZGVPSUIZOCY-UHFFFAOYSA-N 18471 2-[(4-{[2-(tert-butoxy)phenyl]amino}-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]ethan-1-ol::triazine scaffold, 37 Lysosomal acid glucosylceramidase Homo sapiens 330 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18471&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17757274 46518545 ZINC13829544 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32953 OCCNc1nc(Nc2ccccc2OCc2ccccc2)nc(n1)N1CCCC1 InChI=1S/C22H26N6O2/c29-15-12-23-20-25-21(27-22(26-20)28-13-6-7-14-28)24-18-10-4-5-11-19(18)30-16-17-8-2-1-3-9-17/h1-5,8-11,29H,6-7,12-16H2,(H2,23,24,25,26,27) VXLLFCPIBDPYFW-UHFFFAOYSA-N 18472 2-[(4-{[2-(benzyloxy)phenyl]amino}-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]ethan-1-ol::triazine scaffold, 38 Lysosomal acid glucosylceramidase Homo sapiens 31400 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18472&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648027 46518546 ZINC14968070 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32954 OCCNc1nc(Nc2ccccc2OC(F)(F)F)nc(n1)N1CCCC1 InChI=1S/C16H19F3N6O2/c17-16(18,19)27-12-6-2-1-5-11(12)21-14-22-13(20-7-10-26)23-15(24-14)25-8-3-4-9-25/h1-2,5-6,26H,3-4,7-10H2,(H2,20,21,22,23,24) DHTBCMKUVOXAGA-UHFFFAOYSA-N 18473 2-{[4-(pyrrolidin-1-yl)-6-{[2-(trifluoromethoxy)phenyl]amino}-1,3,5-triazin-2-yl]amino}ethan-1-ol::triazine scaffold, 39 Lysosomal acid glucosylceramidase Homo sapiens 3340 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18473&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648028 46518547 ZINC12509004 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32955 CSc1ccccc1Nc1nc(NCCO)nc(n1)N1CCCC1 InChI=1S/C16H22N6OS/c1-24-13-7-3-2-6-12(13)18-15-19-14(17-8-11-23)20-16(21-15)22-9-4-5-10-22/h2-3,6-7,23H,4-5,8-11H2,1H3,(H2,17,18,19,20,21) LOVNEHZOSOGCRZ-UHFFFAOYSA-N 18474 2-[(4-{[2-(methylsulfanyl)phenyl]amino}-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]ethan-1-ol::triazine scaffold, 40 Lysosomal acid glucosylceramidase Homo sapiens 2390 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18474&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648029 46518548 ZINC14968074 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32956 COc1ccc(OC)c(Nc2nc(NCCO)nc(n2)N2CCCC2)c1 InChI=1S/C17H24N6O3/c1-25-12-5-6-14(26-2)13(11-12)19-16-20-15(18-7-10-24)21-17(22-16)23-8-3-4-9-23/h5-6,11,24H,3-4,7-10H2,1-2H3,(H2,18,19,20,21,22) BDVNDOKOCNTPFX-UHFFFAOYSA-N 18475 2-({4-[(2,5-dimethoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 41 Lysosomal acid glucosylceramidase Homo sapiens 1530 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18475&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648030 46518549 ZINC14968078 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32957 COc1ccc(Nc2nc(NCCO)nc(n2)N2CCCC2)c(OC)c1 InChI=1S/C17H24N6O3/c1-25-12-5-6-13(14(11-12)26-2)19-16-20-15(18-7-10-24)21-17(22-16)23-8-3-4-9-23/h5-6,11,24H,3-4,7-10H2,1-2H3,(H2,18,19,20,21,22) BIMNJVGNERQUJO-UHFFFAOYSA-N 18476 2-({4-[(2,4-dimethoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 42 Lysosomal acid glucosylceramidase Homo sapiens 4900 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18476&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648031 46518550 ZINC14968082 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32958 COc1ccc(cc1Nc1nc(NCCO)nc(n1)N1CCCC1)C(F)(F)F InChI=1S/C17H21F3N6O2/c1-28-13-5-4-11(17(18,19)20)10-12(13)22-15-23-14(21-6-9-27)24-16(25-15)26-7-2-3-8-26/h4-5,10,27H,2-3,6-9H2,1H3,(H2,21,22,23,24,25) QMCHISMLXLNWOA-UHFFFAOYSA-N 18477 2-[(4-{[2-methoxy-5-(trifluoromethyl)phenyl]amino}-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]ethan-1-ol::triazine scaffold, 43 Lysosomal acid glucosylceramidase Homo sapiens 2650 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18477&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648032 46518551 ZINC14968087 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32959 COc1ccc(cc1Nc1nc(NCCO)nc(n1)N1CCCC1)-c1ccccc1 InChI=1S/C22H26N6O2/c1-30-19-10-9-17(16-7-3-2-4-8-16)15-18(19)24-21-25-20(23-11-14-29)26-22(27-21)28-12-5-6-13-28/h2-4,7-10,15,29H,5-6,11-14H2,1H3,(H2,23,24,25,26,27) YKXOTVVZUFEPMC-UHFFFAOYSA-N 18478 2-({4-[(2-methoxy-5-phenylphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 44 Lysosomal acid glucosylceramidase Homo sapiens 2220 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18478&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648033 46518552 ZINC14968091 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32960 OCCNc1nc(Nc2cc(Cl)ccc2O)nc(n1)N1CCCC1 InChI=1S/C15H19ClN6O2/c16-10-3-4-12(24)11(9-10)18-14-19-13(17-5-8-23)20-15(21-14)22-6-1-2-7-22/h3-4,9,23-24H,1-2,5-8H2,(H2,17,18,19,20,21) YVHUOXWQVUSZKG-UHFFFAOYSA-N 18479 4-chloro-2-({4-[(2-hydroxyethyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)phenol::triazine scaffold, 48 Lysosomal acid glucosylceramidase Homo sapiens 730 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18479&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648034 46518553 ZINC14968095 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32961 OCCNc1nc(Nc2cc(ccc2O)-c2ccccc2)nc(n1)N1CCCC1 InChI=1S/C21H24N6O2/c28-13-10-22-19-24-20(26-21(25-19)27-11-4-5-12-27)23-17-14-16(8-9-18(17)29)15-6-2-1-3-7-15/h1-3,6-9,14,28-29H,4-5,10-13H2,(H2,22,23,24,25,26) FEQNEXSELHWMTI-UHFFFAOYSA-N 18480 2-({4-[(2-hydroxyethyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)-4-phenylphenol::triazine scaffold, 49 Lysosomal acid glucosylceramidase Homo sapiens 370 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18480&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648035 46518554 ZINC14968099 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32962 CCOc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCC1 InChI=1S/C17H23ClN6O2/c1-2-26-14-6-5-12(18)11-13(14)20-16-21-15(19-7-10-25)22-17(23-16)24-8-3-4-9-24/h5-6,11,25H,2-4,7-10H2,1H3,(H2,19,20,21,22,23) QBTRNSWZTVNAIG-UHFFFAOYSA-N 18481 2-({4-[(5-chloro-2-ethoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::triazine scaffold, 50 Lysosomal acid glucosylceramidase Homo sapiens 960 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18481&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648036 46518555 ZINC12726121 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32963 CC(C)Oc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCC1 InChI=1S/C18H25ClN6O2/c1-12(2)27-15-6-5-13(19)11-14(15)21-17-22-16(20-7-10-26)23-18(24-17)25-8-3-4-9-25/h5-6,11-12,26H,3-4,7-10H2,1-2H3,(H2,20,21,22,23,24) IYWLOUCQMHQNNE-UHFFFAOYSA-N 18482 2-[(4-{[5-chloro-2-(propan-2-yloxy)phenyl]amino}-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]ethan-1-ol::cid_23648037::triazine scaffold, 51 Lysosomal acid glucosylceramidase Homo sapiens 3440 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18482&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648037 46518556 ZINC12726118 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32964 CC(C)(C)Oc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCC1 InChI=1S/C19H27ClN6O2/c1-19(2,3)28-15-7-6-13(20)12-14(15)22-17-23-16(21-8-11-27)24-18(25-17)26-9-4-5-10-26/h6-7,12,27H,4-5,8-11H2,1-3H3,(H2,21,22,23,24,25) SEVHBJITORTPFI-UHFFFAOYSA-N 18483 2-[(4-{[2-(tert-butoxy)-5-chlorophenyl]amino}-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl)amino]ethan-1-ol::triazine scaffold, 52 Lysosomal acid glucosylceramidase Homo sapiens 1040 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18483&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23648038 46518557 ZINC14968104 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32965 OCCNc1nc(Nc2ccccc2)nc(n1)N1CCCC1 InChI=1S/C15H20N6O/c22-11-8-16-13-18-14(17-12-6-2-1-3-7-12)20-15(19-13)21-9-4-5-10-21/h1-3,6-7,22H,4-5,8-11H2,(H2,16,17,18,19,20) NYKSPDHLZGHYMP-UHFFFAOYSA-N 18484 2-{[4-(phenylamino)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl]amino}ethan-1-ol::triazine scaffold, 53 Lysosomal acid glucosylceramidase Homo sapiens 16470 Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18484&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4767568 46518558 ZINC08436198 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 32941 Cc1cccc(Nc2nc(NCCO)nc(n2)N2CCCC2)c1 InChI=1S/C16H22N6O/c1-12-5-4-6-13(11-12)18-15-19-14(17-7-10-23)20-16(21-15)22-8-2-3-9-22/h4-6,11,23H,2-3,7-10H2,1H3,(H2,17,18,19,20,21) DSLSXSSYABXXSB-UHFFFAOYSA-N 18448 2-({4-[(3-methylphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::Triazine compound, 27::triazine scaffold, 26 Lysosomal acid glucosylceramidase Homo sapiens 6190 5.9 21.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.08.050 10.7270/Q2Q81BBW 17827006 aid1797734 Huang, W; Zheng, W; Urban, DJ; Inglese, J; Sidransky, E; Austin, CP; Thomas, CJ NIH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18448&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3146158 46518522 ZINC03625134 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 64467 CC1=CC(C)=[N+]2C1=C(CCCCc1cn(C[C@H]3[C@H]4O[C@H]4[C@H](O)[C@@H](O)[C@@H]3O)nn1)c1c(C)cc(C)n1[B-]2(F)F InChI=1S/C26H34BF2N5O4/c1-13-9-15(3)33-20(13)18(21-14(2)10-16(4)34(21)27(33,28)29)8-6-5-7-17-11-32(31-30-17)12-19-22(35)23(36)24(37)26-25(19)38-26/h9-11,19,22-26,35-37H,5-8,12H2,1-4H3/t19-,22-,23+,24-,25-,26+/m1/s1 IZGBBUJVVVRRFK-DQTYAKANSA-N 36514 CID46912122::MDW933, 5 Lysosomal acid glucosylceramidase Homo sapiens 7 1.24 5.2 37.00 C Curated from the literature by BindingDB 10.1038/nchembio.466 10.7270/Q2FX77ST 21079602 aid1799421 Witte, MD; Kallemeijn, WW; Aten, J; Li, KY; Strijland, A; Donker-Koopman, WE; van den Nieuwendijk, AM; Bleijlevens, B; Kramer, G; Florea, BI; Hooibrink, B; Hollak, CE; Ottenhoff, R; Boot, RG; van der Marel, GA; Overkleeft, HS; Aerts, JM Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36514&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46912122 117644100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 64468 COc1ccc(cc1)C1=[N+]2C(C=C1)=C(CCCCc1cn(C[C@H]3[C@H]4O[C@H]4[C@H](O)[C@@H](O)[C@@H]3O)nn1)c1ccc(-c3ccc(OC)cc3)n1[B-]2(F)F InChI=1S/C36H38BF2N5O6/c1-48-24-11-7-21(8-12-24)28-15-17-30-26(31-18-16-29(44(31)37(38,39)43(28)30)22-9-13-25(49-2)14-10-22)6-4-3-5-23-19-42(41-40-23)20-27-32(45)33(46)34(47)36-35(27)50-36/h7-19,27,32-36,45-47H,3-6,20H2,1-2H3/t27-,32-,33+,34-,35-,36+/m1/s1 OWVDUFOFLDIMAR-SVBJHREWSA-N 36515 CID46912120::MDW941, 6 Lysosomal acid glucosylceramidase Homo sapiens 8 1.94 5.2 37.00 C Curated from the literature by BindingDB 10.1038/nchembio.466 10.7270/Q2FX77ST 21079602 aid1799421 Witte, MD; Kallemeijn, WW; Aten, J; Li, KY; Strijland, A; Donker-Koopman, WE; van den Nieuwendijk, AM; Bleijlevens, B; Kramer, G; Florea, BI; Hooibrink, B; Hollak, CE; Ottenhoff, R; Boot, RG; van der Marel, GA; Overkleeft, HS; Aerts, JM Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36515&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46912120 117644101 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 64469 OC[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C7H12O5/c8-1-2-3(9)4(10)5(11)7-6(2)12-7/h2-11H,1H2/t2-,3-,4+,5-,6-,7+/m1/s1 YQLWKYQDOQEWRD-GEGSFZHJSA-N 36512 CID164227::Cylcophellitol, 3 Lysosomal acid glucosylceramidase Homo sapiens 152 1.5e+2 5.2 37.00 C Curated from the literature by BindingDB 10.1038/nchembio.466 10.7270/Q2FX77ST 21079602 aid1799421 Witte, MD; Kallemeijn, WW; Aten, J; Li, KY; Strijland, A; Donker-Koopman, WE; van den Nieuwendijk, AM; Bleijlevens, B; Kramer, G; Florea, BI; Hooibrink, B; Hollak, CE; Ottenhoff, R; Boot, RG; van der Marel, GA; Overkleeft, HS; Aerts, JM Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36512&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 164227 117644098 ZINC05131881 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 64470 O[C@H]1[C@@H]2O[C@@H]2[C@H](CN=[N+]=[N-])[C@@H](O)[C@@H]1O InChI=1S/C7H11N3O4/c8-10-9-1-2-3(11)4(12)5(13)7-6(2)14-7/h2-7,11-13H,1H2/t2-,3-,4+,5-,6-,7+/m1/s1 ZESQJCJZDKDCAM-GEGSFZHJSA-N 36513 CID46912128::KY170, 4::US9056847, Azido-cyclophellitol Lysosomal acid glucosylceramidase Homo sapiens 44 1.2e+2 5.2 37.00 C Curated from the literature by BindingDB 10.1038/nchembio.466 10.7270/Q2FX77ST 21079602 aid1799421 Witte, MD; Kallemeijn, WW; Aten, J; Li, KY; Strijland, A; Donker-Koopman, WE; van den Nieuwendijk, AM; Bleijlevens, B; Kramer, G; Florea, BI; Hooibrink, B; Hollak, CE; Ottenhoff, R; Boot, RG; van der Marel, GA; Overkleeft, HS; Aerts, JM Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36513&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46912128 117644099 ZINC34116219 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 64471 O[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/m0/s1 ZHMWOVGZCINIHW-FTYOSCRSSA-N 50078114 (1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,3,4,5-tetraol::CHEMBL291020::Conduritol B Epoxide::Conduritol B Epoxide, 2::US9056847, Conduritol B- epoxide Lysosomal acid glucosylceramidase Homo sapiens 5.3e+4 9.49e+3 5.2 37.00 C Curated from the literature by BindingDB 10.1038/nchembio.466 10.7270/Q2FX77ST 21079602 aid1799421 Witte, MD; Kallemeijn, WW; Aten, J; Li, KY; Strijland, A; Donker-Koopman, WE; van den Nieuwendijk, AM; Bleijlevens, B; Kramer, G; Florea, BI; Hooibrink, B; Hollak, CE; Ottenhoff, R; Boot, RG; van der Marel, GA; Overkleeft, HS; Aerts, JM Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078114&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 119054 103970749 67235 CHEMBL291020 ZINC17995199 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79126 Cc1nc2sccn2c1-c1csc(Nc2cc(C)ccn2)n1 InChI=1S/C15H13N5S2/c1-9-3-4-16-12(7-9)19-14-18-11(8-22-14)13-10(2)17-15-20(13)5-6-21-15/h3-8H,1-2H3,(H,16,18,19) IFAWIELOCTZGNZ-UHFFFAOYSA-N 32259 4-(6-methyl-5-imidazo[2,1-b]thiazolyl)-N-(4-methyl-2-pyridinyl)-2-thiazolamine::4-(6-methylimidazo[2,1-b][1,3]thiazol-5-yl)-N-(4-methylpyridin-2-yl)-1,3-thiazol-2-amine::MLS000034327::SMR000010233::[4-(6-Methyl-imidazo[2,1-b]thiazol-5-yl)-thiazol-2-yl]-(4-methyl-pyridin-2-yl)-amine::[4-(6-methylimidazo[2,1-b]thiazol-5-yl)thiazol-2-yl]-(4-methyl-2-pyridyl)amine::cid_644740 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32259&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 644740 252615705 ZINC04135704 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79127 CCc1ccc(NC(=O)Cn2c(SC)nc3ccccc23)cc1 InChI=1S/C18H19N3OS/c1-3-13-8-10-14(11-9-13)19-17(22)12-21-16-7-5-4-6-15(16)20-18(21)23-2/h4-11H,3,12H2,1-2H3,(H,19,22) YVTQQBUMRYYLDL-UHFFFAOYSA-N 30999 MLS000031858::N-(4-Ethyl-phenyl)-2-(2-methylsulfanyl-benzoimidazol-1-yl)-acetamide::N-(4-ethylphenyl)-2-(2-methylsulfanylbenzimidazol-1-yl)acetamide::N-(4-ethylphenyl)-2-(2-methylsulfanylbenzimidazol-1-yl)ethanamide::N-(4-ethylphenyl)-2-[2-(methylthio)-1-benzimidazolyl]acetamide::N-(4-ethylphenyl)-2-[2-(methylthio)benzimidazol-1-yl]acetamide::SMR000012737::cid_644926 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30999&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 644926 252615252 ZINC00060903 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79128 CC(C)Oc1cccc(c1)C(=O)Nc1ccccc1N1CCOCC1 InChI=1S/C20H24N2O3/c1-15(2)25-17-7-5-6-16(14-17)20(23)21-18-8-3-4-9-19(18)22-10-12-24-13-11-22/h3-9,14-15H,10-13H2,1-2H3,(H,21,23) QIYQYDQXTZZCIX-UHFFFAOYSA-N 42265 3-Isopropoxy-N-(2-morpholin-4-yl-phenyl)-benzamide::3-isopropoxy-N-(2-morpholinophenyl)benzamide::MLS000034308::N-(2-morpholin-4-ylphenyl)-3-propan-2-yloxy-benzamide::N-(2-morpholin-4-ylphenyl)-3-propan-2-yloxybenzamide::N-[2-(4-morpholinyl)phenyl]-3-propan-2-yloxybenzamide::SMR000013217::cid_645057 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42265&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 645057 252622970 ZINC00792185 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79129 OC(COCC1CCC=CC1)Cn1cnc2ccccc12 InChI=1S/C17H22N2O2/c20-15(12-21-11-14-6-2-1-3-7-14)10-19-13-18-16-8-4-5-9-17(16)19/h1-2,4-5,8-9,13-15,20H,3,6-7,10-12H2 UEBKCGDQDVQRRE-UHFFFAOYSA-N 42266 1-(1-benzimidazolyl)-3-(1-cyclohex-3-enylmethoxy)-2-propanol::1-(benzimidazol-1-yl)-3-(cyclohex-3-en-1-ylmethoxy)propan-2-ol::1-Benzoimidazol-1-yl-3-(cyclohex-3-enylmethoxy)-propan-2-ol::MLS000076198::SMR000010409::cid_645134 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42266&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 645134 252622971 ZINC00180990 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79130 COCCNC(=O)C(N(CC=C)C(=O)Cn1nnc2ccccc12)c1ccc(OC)cc1OC InChI=1S/C24H29N5O5/c1-5-13-28(22(30)16-29-20-9-7-6-8-19(20)26-27-29)23(24(31)25-12-14-32-2)18-11-10-17(33-3)15-21(18)34-4/h5-11,15,23H,1,12-14,16H2,2-4H3,(H,25,31) UPDGKKWDZRYOHL-UHFFFAOYSA-N 42267 2-[2-(benzotriazol-1-yl)ethanoyl-prop-2-enyl-amino]-2-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)ethanamide::2-[Allyl-(2-benzotriazol-1-yl-acetyl)-amino]-2-(2,4-dimethoxy-phenyl)-N-(2-methoxy-ethyl)-acetamide::2-[[2-(1-benzotriazolyl)-1-oxoethyl]-prop-2-enylamino]-2-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)acetamide::2-[[2-(benzotriazol-1-yl)acetyl]-prop-2-enylamino]-2-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)acetamide::2-[allyl-[2-(benzotriazol-1-yl)acetyl]amino]-2-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)acetamide::MLS000031807::SMR000005235::cid_645363 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42267&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 645363 252622972 ZINC06552061 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79131 O=C(NCc1ccco1)c1ccc(cc1)S(=O)(=O)NCC1CCCO1 InChI=1S/C17H20N2O5S/c20-17(18-11-14-3-1-9-23-14)13-5-7-16(8-6-13)25(21,22)19-12-15-4-2-10-24-15/h1,3,5-9,15,19H,2,4,10-12H2,(H,18,20) MCSIIFVISAGUFS-UHFFFAOYSA-N 40567 MLS000076175::N-(2-furanylmethyl)-4-(2-oxolanylmethylsulfamoyl)benzamide::N-(2-furfuryl)-4-(tetrahydrofurfurylsulfamoyl)benzamide::N-(furan-2-ylmethyl)-4-(oxolan-2-ylmethylsulfamoyl)benzamide::N-Furan-2-ylmethyl-4-[(tetrahydro-furan-2-ylmethyl)-sulfamoyl]-benzamide::SMR000003926::cid_645494 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40567&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 645494 252621388 ZINC01324797 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79132 CCOc1ccccc1-n1c(SCC(N)=O)nnc1-c1ccc(O)cc1 InChI=1S/C18H18N4O3S/c1-2-25-15-6-4-3-5-14(15)22-17(12-7-9-13(23)10-8-12)20-21-18(22)26-11-16(19)24/h3-10,23H,2,11H2,1H3,(H2,19,24) NVWVYZVBCXOXMA-UHFFFAOYSA-N 42268 2-[4-(2-Ethoxy-phenyl)-5-(4-hydroxy-phenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-acetamide::2-[[4-(2-ethoxyphenyl)-5-(4-oxidanylidenecyclohexa-2,5-dien-1-ylidene)-1H-1,2,4-triazol-3-yl]sulfanyl]ethanamide::2-[[4-(2-ethoxyphenyl)-5-(4-oxo-1-cyclohexa-2,5-dienylidene)-1H-1,2,4-triazol-3-yl]thio]acetamide::2-[[4-(2-ethoxyphenyl)-5-(4-oxocyclohexa-2,5-dien-1-ylidene)-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide::2-[[5-(4-ketocyclohexa-2,5-dien-1-ylidene)-4-o-phenetyl-1H-1,2,4-triazol-3-yl]thio]acetamide::MLS000031819::SMR000002769::cid_5447470 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42268&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 5447470 252622973 ZINC96243310 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79133 Fc1ccc2[nH]c3nc(SCC(=O)OCc4ccccc4)nnc3c2c1 InChI=1S/C18H13FN4O2S/c19-12-6-7-14-13(8-12)16-17(20-14)21-18(23-22-16)26-10-15(24)25-9-11-4-2-1-3-5-11/h1-8H,9-10H2,(H,20,21,23) OWABXZDBNZGBHE-UHFFFAOYSA-N 42269 (8-Fluoro-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)-acetic acid benzyl ester::(phenylmethyl) 2-[(8-fluoranyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]ethanoate::2-[(8-fluoro-5H-[1,2,4]triazin[5,6-b]indol-3-yl)thio]acetic acid benzyl ester::2-[(8-fluoro-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio]acetic acid (phenylmethyl) ester::MLS000072691::SMR000001812::benzyl 2-[(8-fluoro-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetate::cid_6398898 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42269&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 6398898 252622974 ZINC01221409 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79134 CC(CS(=O)(=O)c1cccc2cccnc12)N1CCCCC1 InChI=1S/C17H22N2O2S/c1-14(19-11-3-2-4-12-19)13-22(20,21)16-9-5-7-15-8-6-10-18-17(15)16/h5-10,14H,2-4,11-13H2,1H3 DNDGLAABZUMJHF-UHFFFAOYSA-N 42270 8-(2-Piperidin-1-yl-propane-1-sulfonyl)-quinoline::8-(2-piperidin-1-ylpropylsulfonyl)quinoline::8-(2-piperidinopropylsulfonyl)quinoline::8-[2-(1-piperidinyl)propylsulfonyl]quinoline::MLS000029906::SMR000012923::cid_646121 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42270&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 646121 252622975 ZINC04704590 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79135 Cc1nc(C)c(s1)-c1csc(NCc2ccco2)n1 InChI=1S/C13H13N3OS2/c1-8-12(19-9(2)15-8)11-7-18-13(16-11)14-6-10-4-3-5-17-10/h3-5,7H,6H2,1-2H3,(H,14,16) RWSCDFSCSDPGCF-UHFFFAOYSA-N 42271 (2',4'-Dimethyl-[4,5']bithiazolyl-2-yl)-furan-2-ylmethyl-amine::4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-(furan-2-ylmethyl)-1,3-thiazol-2-amine::4-(2,4-dimethyl-5-thiazolyl)-N-(2-furanylmethyl)-2-thiazolamine::MLS000034305::SMR000011632::[4-(2,4-dimethylthiazol-5-yl)thiazol-2-yl]-(2-furfuryl)amine::cid_646758 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42271&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 646758 252622976 ZINC00190350 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79136 CCOC(=O)COc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C18H16N2O4/c1-2-22-16(21)12-23-15-10-8-14(9-11-15)18-20-19-17(24-18)13-6-4-3-5-7-13/h3-11H,2,12H2,1H3 BZAQOWWLZDSWSH-UHFFFAOYSA-N 42272 2-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy]acetic acid ethyl ester::MLS000031798::SMR000002388::[4-(5-Phenyl-[1,3,4]oxadiazol-2-yl)-phenoxy]-acetic acid ethyl ester::cid_647355::ethyl 2-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy]acetate::ethyl 2-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy]ethanoate Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42272&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 647355 252622977 ZINC00417645 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79137 CC(OC(=O)c1nsc(Cl)c1Cl)C(=O)NCc1cccs1 InChI=1S/C12H10Cl2N2O3S2/c1-6(11(17)15-5-7-3-2-4-20-7)19-12(18)9-8(13)10(14)21-16-9/h2-4,6H,5H2,1H3,(H,15,17) CKTHRALBLNYWDD-UHFFFAOYSA-N 42273 4,5-Dichloro-isothiazole-3-carboxylic acid 1-[(thiophen-2-ylmethyl)-carbamoyl]-ethyl ester::4,5-dichloro-3-isothiazolecarboxylic acid [1-oxo-1-(thiophen-2-ylmethylamino)propan-2-yl] ester::4,5-dichloroisothiazole-3-carboxylic acid [2-keto-1-methyl-2-(2-thenylamino)ethyl] ester::MLS000073961::SMR000006588::[1-oxidanylidene-1-(thiophen-2-ylmethylamino)propan-2-yl] 4,5-bis(chloranyl)-1,2-thiazole-3-carboxylate::[1-oxo-1-(thiophen-2-ylmethylamino)propan-2-yl] 4,5-dichloro-1,2-thiazole-3-carboxylate::cid_647824 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42273&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 647824 252622978 ZINC01381289 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79138 COc1ccc(cc1)S(=O)(=O)NCC(=O)N(CC(=O)NCC1CCCO1)c1ccccc1C InChI=1S/C23H29N3O6S/c1-17-6-3-4-8-21(17)26(16-22(27)24-14-19-7-5-13-32-19)23(28)15-25-33(29,30)20-11-9-18(31-2)10-12-20/h3-4,6,8-12,19,25H,5,7,13-16H2,1-2H3,(H,24,27) FYANNMRFPSTTNG-UHFFFAOYSA-N 42274 2-(4-Methoxy-benzenesulfonylamino)-N-{[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-methyl}-N-o-tolyl-acetamide::2-[(4-methoxyphenyl)sulfonylamino]-N-(2-methylphenyl)-N-[2-oxidanylidene-2-(oxolan-2-ylmethylamino)ethyl]ethanamide::2-[(4-methoxyphenyl)sulfonylamino]-N-(2-methylphenyl)-N-[2-oxo-2-(2-oxolanylmethylamino)ethyl]acetamide::2-[(4-methoxyphenyl)sulfonylamino]-N-(2-methylphenyl)-N-[2-oxo-2-(oxolan-2-ylmethylamino)ethyl]acetamide::MLS000031838::N-[2-keto-2-(tetrahydrofurfurylamino)ethyl]-2-[(4-methoxyphenyl)sulfonylamino]-N-(o-tolyl)acetamide::SMR000004757::cid_648647 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42274&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 648647 252622979 ZINC04410761 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79139 COCCCNC(=O)Cn1cc(C(=O)C2CC2)c2ccccc12 InChI=1S/C18H22N2O3/c1-23-10-4-9-19-17(21)12-20-11-15(18(22)13-7-8-13)14-5-2-3-6-16(14)20/h2-3,5-6,11,13H,4,7-10,12H2,1H3,(H,19,21) XLXYRBAJDVPLEG-UHFFFAOYSA-N 42275 2-(3-Cyclopropanecarbonyl-indol-1-yl)-N-(3-methoxy-propyl)-acetamide::2-(3-cyclopropylcarbonylindol-1-yl)-N-(3-methoxypropyl)ethanamide::2-[3-(cyclopropanecarbonyl)indol-1-yl]-N-(3-methoxypropyl)acetamide::2-[3-[cyclopropyl(oxo)methyl]-1-indolyl]-N-(3-methoxypropyl)acetamide::MLS000033991::SMR000014346::cid_648985 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42275&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 648985 252622980 ZINC03648645 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79140 CC(C)CCn1nnnc1C(N1CCC(CC1)C(N)=O)c1ccccc1 InChI=1S/C19H28N6O/c1-14(2)8-13-25-19(21-22-23-25)17(15-6-4-3-5-7-15)24-11-9-16(10-12-24)18(20)26/h3-7,14,16-17H,8-13H2,1-2H3,(H2,20,26) GNLIJWXOLAWIKS-UHFFFAOYSA-N 42276 1-[(1-isoamyltetrazol-5-yl)-phenyl-methyl]isonipecotamide::1-[[1-(3-methylbutyl)-1,2,3,4-tetrazol-5-yl]-phenyl-methyl]piperidine-4-carboxamide::1-[[1-(3-methylbutyl)-5-tetrazolyl]-phenylmethyl]-4-piperidinecarboxamide::1-[[1-(3-methylbutyl)tetrazol-5-yl]-phenylmethyl]piperidine-4-carboxamide::1-{[1-(3-Methyl-butyl)-1H-tetrazol-5-yl]-phenyl-methyl}-piperidine-4-carboxylic acid amide::MLS000074035::SMR000005065::cid_648991 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42276&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 648991 252622981 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79141 O=C(CNC(=O)c1cccs1)N(C(C(=O)NC1CCCC1)c1ccco1)c1cccnc1 InChI=1S/C23H24N4O4S/c28-20(15-25-22(29)19-10-5-13-32-19)27(17-8-3-11-24-14-17)21(18-9-4-12-31-18)23(30)26-16-6-1-2-7-16/h3-5,8-14,16,21H,1-2,6-7,15H2,(H,25,29)(H,26,30) RTWIGDSKZRVAPH-UHFFFAOYSA-N 42277 MLS000072166::N-[2-[[2-(cyclopentylamino)-1-(2-furanyl)-2-oxoethyl]-(3-pyridinyl)amino]-2-oxoethyl]-2-thiophenecarboxamide::N-[2-[[2-(cyclopentylamino)-1-(2-furyl)-2-keto-ethyl]-(3-pyridyl)amino]-2-keto-ethyl]thiophene-2-carboxamide::N-[2-[[2-(cyclopentylamino)-1-(furan-2-yl)-2-oxidanylidene-ethyl]-pyridin-3-yl-amino]-2-oxidanylidene-ethyl]thiophene-2-carboxamide::N-[2-[[2-(cyclopentylamino)-1-(furan-2-yl)-2-oxoethyl]-pyridin-3-ylamino]-2-oxoethyl]thiophene-2-carboxamide::SMR000005156::Thiophene-2-carboxylic acid {[(cyclopentylcarbamoyl-furan-2-yl-methyl)-pyridin-3-yl-carbamoyl]-methyl}-amide::cid_649544 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42277&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 649544 252622982 ZINC04093238 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79142 CC(=O)Nc1cccc(NC(=O)C2CCCN2C(=O)Nc2ccc(C)cc2)c1 InChI=1S/C21H24N4O3/c1-14-8-10-16(11-9-14)24-21(28)25-12-4-7-19(25)20(27)23-18-6-3-5-17(13-18)22-15(2)26/h3,5-6,8-11,13,19H,4,7,12H2,1-2H3,(H,22,26)(H,23,27)(H,24,28) VARDJHYZPHXUPT-UHFFFAOYSA-N 42278 2-N-(3-acetamidophenyl)-1-N-(4-methylphenyl)pyrrolidine-1,2-dicarboxamide::MLS000035054::N'-(3-acetamidophenyl)-N-(p-tolyl)pyrrolidine-1,2-dicarboxamide::N2-(3-acetamidophenyl)-N1-(4-methylphenyl)pyrrolidine-1,2-dicarboxamide::Pyrrolidine-1,2-dicarboxylic acid 2-[(3-acetylamino-phenyl)-amide] 1-p-tolylamide::SMR000006393::cid_650709 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42278&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 650709 252622983 ZINC01379731 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79143 CCN1CCN(CC1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C19H21N5/c1-2-23-10-12-24(13-11-23)19-16-7-3-4-8-17(16)21-18(22-19)15-6-5-9-20-14-15/h3-9,14H,2,10-13H2,1H3 JGJMAGYJXPIPPW-UHFFFAOYSA-N 42279 4-(4-Ethyl-piperazin-1-yl)-2-pyridin-3-yl-quinazoline::4-(4-ethyl-1-piperazinyl)-2-(3-pyridinyl)quinazoline;hydrochloride::4-(4-ethylpiperazin-1-yl)-2-pyridin-3-yl-quinazoline;hydrochloride::4-(4-ethylpiperazin-1-yl)-2-pyridin-3-ylquinazoline;hydrochloride::4-(4-ethylpiperazino)-2-(3-pyridyl)quinazoline;hydrochloride::MLS000069125::SMR000011754::cid_6603177 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42279&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 650923 252622984 ZINC00038303 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79144 Cc1ccc(C)c(c1)C(=O)C1C(N(CCCn2ccnc2)C(=O)C1=O)c1ccncc1 InChI=1S/C24H24N4O3/c1-16-4-5-17(2)19(14-16)22(29)20-21(18-6-8-25-9-7-18)28(24(31)23(20)30)12-3-11-27-13-10-26-15-27/h4-10,13-15,20-21H,3,11-12H2,1-2H3 VLKYCYREEVDMMP-UHFFFAOYSA-N 37614 (4E)-4-[(2,5-dimethylphenyl)-hydroxy-methylene]-1-(3-imidazol-1-ylpropyl)-5-(4-pyridyl)pyrrolidine-2,3-quinone::(4E)-4-[(2,5-dimethylphenyl)-hydroxymethylidene]-1-(3-imidazol-1-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione::(4E)-4-[(2,5-dimethylphenyl)-hydroxymethylidene]-1-[3-(1-imidazolyl)propyl]-5-pyridin-4-ylpyrrolidine-2,3-dione::(4E)-4-[(2,5-dimethylphenyl)-oxidanyl-methylidene]-1-(3-imidazol-1-ylpropyl)-5-pyridin-4-yl-pyrrolidine-2,3-dione::4-(2,5-Dimethyl-benzoyl)-3-hydroxy-1-(3-imidazol-1-yl-propyl)-5-pyridin-4-yl-1,5-dihydro-pyrrol-2-one::MLS000033888::SMR000013600::cid_5769015 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37614&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 91896287 252618583 ZINC04093039 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79145 Cc1nonc1NC(=O)CSc1nc2cc(Cl)ccc2c2CCCCc12 InChI=1S/C18H17ClN4O2S/c1-10-17(23-25-22-10)21-16(24)9-26-18-14-5-3-2-4-12(14)13-7-6-11(19)8-15(13)20-18/h6-8H,2-5,9H2,1H3,(H,21,23,24) KZJUVEPDMFXBJC-UHFFFAOYSA-N 42280 2-(3-Chloro-7,8,9,10-tetrahydro-phenanthridin-6-ylsulfanyl)-N-(4-methyl-furazan-3-yl)-acetamide::2-[(3-chloranyl-7,8,9,10-tetrahydrophenanthridin-6-yl)sulfanyl]-N-(4-methyl-1,2,5-oxadiazol-3-yl)ethanamide::2-[(3-chloro-7,8,9,10-tetrahydrophenanthridin-6-yl)sulfanyl]-N-(4-methyl-1,2,5-oxadiazol-3-yl)acetamide::2-[(3-chloro-7,8,9,10-tetrahydrophenanthridin-6-yl)thio]-N-(4-methyl-1,2,5-oxadiazol-3-yl)acetamide::2-[(3-chloro-7,8,9,10-tetrahydrophenanthridin-6-yl)thio]-N-(4-methylfurazan-3-yl)acetamide::MLS000033382::SMR000007247::cid_650995 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42280&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 650995 252622985 ZINC04093031 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79146 COc1ccc(CNC(=O)CN(CC2CCCO2)C(=O)CNS(=O)(=O)c2ccc(C)cc2)cc1 InChI=1S/C24H31N3O6S/c1-18-5-11-22(12-6-18)34(30,31)26-15-24(29)27(16-21-4-3-13-33-21)17-23(28)25-14-19-7-9-20(32-2)10-8-19/h5-12,21,26H,3-4,13-17H2,1-2H3,(H,25,28) UPKJQTGLLWJNOC-UHFFFAOYSA-N 42281 MLS000031928::N-[(4-Methoxy-benzylcarbamoyl)-methyl]-N-(tetrahydro-furan-2-ylmethyl)-2-(toluene-4-sulfonylamino)-acetamide::N-[2-[(4-methoxyphenyl)methylamino]-2-oxidanylidene-ethyl]-2-[(4-methylphenyl)sulfonylamino]-N-(oxolan-2-ylmethyl)ethanamide::N-[2-[(4-methoxyphenyl)methylamino]-2-oxoethyl]-2-[(4-methylphenyl)sulfonylamino]-N-(2-oxolanylmethyl)acetamide::N-[2-[(4-methoxyphenyl)methylamino]-2-oxoethyl]-2-[(4-methylphenyl)sulfonylamino]-N-(oxolan-2-ylmethyl)acetamide::N-[2-keto-2-(p-anisylamino)ethyl]-N-(tetrahydrofurfuryl)-2-(tosylamino)acetamide::SMR000004744::cid_651872 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42281&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 651872 252622986 ZINC04388693 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79147 CCN1CCN(CC1)C(c1nnnn1C(C)(C)C)c1ccc(OC)c(OC)c1 InChI=1S/C20H32N6O2/c1-7-24-10-12-25(13-11-24)18(19-21-22-23-26(19)20(2,3)4)15-8-9-16(27-5)17(14-15)28-6/h8-9,14,18H,7,10-13H2,1-6H3 RWPDRRSKJTUEDJ-UHFFFAOYSA-N 42282 1-[(1-tert-Butyl-1H-tetrazol-5-yl)-(3,4-dimethoxy-phenyl)-methyl]-4-ethyl-piperazine::1-[(1-tert-butyl-1,2,3,4-tetrazol-5-yl)-(3,4-dimethoxyphenyl)methyl]-4-ethyl-piperazine;hydrochloride::1-[(1-tert-butyl-5-tetrazolyl)-(3,4-dimethoxyphenyl)methyl]-4-ethylpiperazine;hydrochloride::1-[(1-tert-butyltetrazol-5-yl)-(3,4-dimethoxyphenyl)methyl]-4-ethyl-piperazine;hydrochloride::1-[(1-tert-butyltetrazol-5-yl)-(3,4-dimethoxyphenyl)methyl]-4-ethylpiperazine;hydrochloride::MLS000029938::SMR000004877::cid_6602654 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42282&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 652163 252622987 ZINC19527981 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79148 CC(C)(C)NC(=O)CSc1nncn1NCc1ccccc1 InChI=1S/C15H21N5OS/c1-15(2,3)18-13(21)10-22-14-19-16-11-20(14)17-9-12-7-5-4-6-8-12/h4-8,11,17H,9-10H2,1-3H3,(H,18,21) HTYMZKCBFICSDS-UHFFFAOYSA-N 42283 2-(4-Benzylamino-4H-[1,2,4]triazol-3-ylsulfanyl)-N-tert-butyl-acetamide::2-[[4-(benzylamino)-1,2,4-triazol-3-yl]sulfanyl]-N-tert-butylacetamide::2-[[4-(benzylamino)-1,2,4-triazol-3-yl]thio]-N-tert-butyl-acetamide::MLS000034273::N-tert-butyl-2-[[4-[(phenylmethyl)amino]-1,2,4-triazol-3-yl]sulfanyl]ethanamide::N-tert-butyl-2-[[4-[(phenylmethyl)amino]-1,2,4-triazol-3-yl]thio]acetamide::SMR000014148::cid_653197 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42283&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 653197 252622988 ZINC00359928 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79149 O=C(OCCN1CCCCC1)c1cc2ccccc2o1 InChI=1S/C16H19NO3/c18-16(19-11-10-17-8-4-1-5-9-17)15-12-13-6-2-3-7-14(13)20-15/h2-3,6-7,12H,1,4-5,8-11H2 RQFJVHRHAIKAOP-UHFFFAOYSA-N 42284 2-benzofurancarboxylic acid 2-(1-piperidinyl)ethyl ester;hydrochloride::2-piperidin-1-ylethyl 1-benzofuran-2-carboxylate;hydrochloride::Benzofuran-2-carboxylic acid 2-piperidin-1-yl-ethyl ester::MLS000076177::SMR000014395::cid_6603492::coumarilic acid 2-piperidinoethyl ester;hydrochloride Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42284&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 653261 252622989 ZINC00808179 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79150 COCCCn1c(SCC(=O)OC2CCCCC2)nnc1-c1ccco1 InChI=1S/C18H25N3O4S/c1-23-11-6-10-21-17(15-9-5-12-24-15)19-20-18(21)26-13-16(22)25-14-7-3-2-4-8-14/h5,9,12,14H,2-4,6-8,10-11,13H2,1H3 OTNSMZRSMCHOSW-UHFFFAOYSA-N 42285 2-[[5-(2-furanyl)-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]thio]acetic acid cyclohexyl ester::2-[[5-(2-furyl)-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]thio]acetic acid cyclohexyl ester::MLS000031830::SMR000002841::[5-Furan-2-yl-4-(3-methoxy-propyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid cyclohexyl ester::cid_653294::cyclohexyl 2-[[5-(furan-2-yl)-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanyl]acetate::cyclohexyl 2-[[5-(furan-2-yl)-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]sulfanyl]ethanoate Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42285&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 653294 252622990 ZINC04161426 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79151 COc1ccc(OC)c(Nc2nc(cs2)-c2sc(N)nc2C)c1 InChI=1S/C15H16N4O2S2/c1-8-13(23-14(16)17-8)11-7-22-15(19-11)18-10-6-9(20-2)4-5-12(10)21-3/h4-7H,1-3H3,(H2,16,17)(H,18,19) HRKHVNBKAKFINO-UHFFFAOYSA-N 42286 5-[2-(2,5-dimethoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-amine::5-[2-(2,5-dimethoxyanilino)-4-thiazolyl]-4-methyl-2-thiazolamine::5-[2-[(2,5-dimethoxyphenyl)amino]-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-amine::MLS000034309::N*2*-(2,5-Dimethoxy-phenyl)-4'-methyl-[4,5']bithiazolyl-2,2'-diamine::SMR000011634::[4-(2-amino-4-methyl-thiazol-5-yl)thiazol-2-yl]-(2,5-dimethoxyphenyl)amine::cid_654122 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42286&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 654122 252622991 ZINC00190506 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79152 CC(C)CC(N1CCN(CC1)C1CCCC1)c1nnnn1CC1CCCO1 InChI=1S/C20H36N6O/c1-16(2)14-19(20-21-22-23-26(20)15-18-8-5-13-27-18)25-11-9-24(10-12-25)17-6-3-4-7-17/h16-19H,3-15H2,1-2H3 WXHLEJHCXOGUNW-UHFFFAOYSA-N 42287 1-Cyclopentyl-4-{3-methyl-1-[1-(tetrahydro-furan-2-ylmethyl)-1H-tetrazol-5-yl]-butyl}-piperazine::1-cyclopentyl-4-[3-methyl-1-[1-(2-oxolanylmethyl)-5-tetrazolyl]butyl]piperazine;hydrochloride::1-cyclopentyl-4-[3-methyl-1-[1-(oxolan-2-ylmethyl)-1,2,3,4-tetrazol-5-yl]butyl]piperazine;hydrochloride::1-cyclopentyl-4-[3-methyl-1-[1-(oxolan-2-ylmethyl)tetrazol-5-yl]butyl]piperazine;hydrochloride::1-cyclopentyl-4-[3-methyl-1-[1-(tetrahydrofurfuryl)tetrazol-5-yl]butyl]piperazine;hydrochloride::MLS000029931::SMR000004939::cid_6602653 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42287&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 654137 252622992 ZINC19446825 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79153 Cc1cc(no1)-c1nnc(SCc2cccnc2)o1 InChI=1S/C12H10N4O2S/c1-8-5-10(16-18-8)11-14-15-12(17-11)19-7-9-3-2-4-13-6-9/h2-6H,7H2,1H3 AFWBCYBFYTVGGP-UHFFFAOYSA-N 42288 2-(5-methyl-1,2-oxazol-3-yl)-5-(pyridin-3-ylmethylsulfanyl)-1,3,4-oxadiazole::2-(5-methyl-3-isoxazolyl)-5-(3-pyridinylmethylthio)-1,3,4-oxadiazole::2-(5-methylisoxazol-3-yl)-5-(3-pyridylmethylthio)-1,3,4-oxadiazole::3-[5-(5-Methyl-isoxazol-3-yl)-[1,3,4]oxadiazol-2-ylsulfanylmethyl]-pyridine::MLS000075236::SMR000008271::cid_654305 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42288&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 654305 252622993 ZINC01337594 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79154 COc1ccc(CN(Cc2cc3cccc(C)c3[nH]c2=O)C(=O)N(C)C)cc1 InChI=1S/C22H25N3O3/c1-15-6-5-7-17-12-18(21(26)23-20(15)17)14-25(22(27)24(2)3)13-16-8-10-19(28-4)11-9-16/h5-12H,13-14H2,1-4H3,(H,23,26) LQKMOHMFSKCWFP-UHFFFAOYSA-N 42289 1-(4-Methoxy-benzyl)-3,3-dimethyl-1-(8-methyl-2-oxo-1,2-dihydro-quinolin-3-ylmethyl)-urea::1-[(2-keto-8-methyl-1H-quinolin-3-yl)methyl]-3,3-dimethyl-1-p-anisyl-urea::1-[(4-methoxyphenyl)methyl]-3,3-dimethyl-1-[(8-methyl-2-oxidanylidene-1H-quinolin-3-yl)methyl]urea::1-[(4-methoxyphenyl)methyl]-3,3-dimethyl-1-[(8-methyl-2-oxo-1H-quinolin-3-yl)methyl]urea::MLS000074000::SMR000006092::cid_654410 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42289&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 654410 252622994 ZINC08617355 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79155 COc1ccc(cc1OC)S(=O)(=O)N(CC(=O)NCC1CCCO1)c1ccccc1 InChI=1S/C21H26N2O6S/c1-27-19-11-10-18(13-20(19)28-2)30(25,26)23(16-7-4-3-5-8-16)15-21(24)22-14-17-9-6-12-29-17/h3-5,7-8,10-11,13,17H,6,9,12,14-15H2,1-2H3,(H,22,24) FUKOMMHZEZJDOZ-UHFFFAOYSA-N 42290 2-(N-(3,4-dimethoxyphenyl)sulfonylanilino)-N-(2-oxolanylmethyl)acetamide::2-(N-(3,4-dimethoxyphenyl)sulfonylanilino)-N-(oxolan-2-ylmethyl)acetamide::2-(N-(3,4-dimethoxyphenyl)sulfonylanilino)-N-(tetrahydrofurfuryl)acetamide::2-[(3,4-Dimethoxy-benzenesulfonyl)-phenyl-amino]-N-(tetrahydro-furan-2-ylmethyl)-acetamide::2-[(3,4-dimethoxyphenyl)sulfonyl-phenyl-amino]-N-(oxolan-2-ylmethyl)ethanamide::MLS000033872::SMR000013914::cid_654500 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42290&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 654500 252622995 ZINC00665663 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79156 Oc1cc(Cc2ccccc2)c(O)n1-c1ccc(Cl)cn1 InChI=1S/C16H13ClN2O2/c17-13-6-7-14(18-10-13)19-15(20)9-12(16(19)21)8-11-4-2-1-3-5-11/h1-7,9-10,20-21H,8H2 PLDDAWOYOFHFGH-UHFFFAOYSA-N 42291 1-(5-chloranylpyridin-2-yl)-3-(phenylmethyl)pyrrolidine-2,5-dione::1-(5-chloro-2-pyridinyl)-3-(phenylmethyl)pyrrolidine-2,5-dione::3-Benzyl-1-(5-chloro-pyridin-2-yl)-pyrrolidine-2,5-dione::3-benzyl-1-(5-chloro-2-pyridyl)pyrrolidine-2,5-quinone::3-benzyl-1-(5-chloropyridin-2-yl)pyrrolidine-2,5-dione::MLS000074762::SMR000013026::cid_654927 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42291&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 91896530 252622996 ZINC85819470 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79157 CC(C)(C)NC(=O)CSc1nnc(-c2ccco2)n1Cc1ccco1 InChI=1S/C17H20N4O3S/c1-17(2,3)18-14(22)11-25-16-20-19-15(13-7-5-9-24-13)21(16)10-12-6-4-8-23-12/h4-9H,10-11H2,1-3H3,(H,18,22) TVPPOVOXHDIISQ-UHFFFAOYSA-N 42292 MLS000031848::N-tert-Butyl-2-(5-furan-2-yl-4-furan-2-ylmethyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetamide::N-tert-butyl-2-[[4-(2-furfuryl)-5-(2-furyl)-1,2,4-triazol-3-yl]thio]acetamide::N-tert-butyl-2-[[5-(2-furanyl)-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]thio]acetamide::N-tert-butyl-2-[[5-(furan-2-yl)-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide::N-tert-butyl-2-[[5-(furan-2-yl)-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanamide::SMR000002849::cid_655446 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42292&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 655446 252622997 ZINC00905299 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79158 Cc1ccn2cc(nc2c1)C(=O)Nc1ccccc1N1CCOCC1 InChI=1S/C19H20N4O2/c1-14-6-7-23-13-16(20-18(23)12-14)19(24)21-15-4-2-3-5-17(15)22-8-10-25-11-9-22/h2-7,12-13H,8-11H2,1H3,(H,21,24) OYNLSGVTEPQTEY-UHFFFAOYSA-N 42293 7-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid (2-morpholin-4-yl-phenyl)-amide::7-methyl-N-(2-morpholin-4-ylphenyl)imidazo[1,2-a]pyridine-2-carboxamide::7-methyl-N-(2-morpholinophenyl)imidazo[1,2-a]pyridine-2-carboxamide::7-methyl-N-[2-(4-morpholinyl)phenyl]-2-imidazo[1,2-a]pyridinecarboxamide::MLS000026853::SMR000003262::cid_655585 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42293&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 655585 252622998 ZINC00415707 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79159 CCOC(=O)C1(Cc2ccc(O)cc2)NC(C2C1C(=O)N(C)C2=O)c1ccccc1F InChI=1S/C23H23FN2O5/c1-3-31-22(30)23(12-13-8-10-14(27)11-9-13)18-17(20(28)26(2)21(18)29)19(25-23)15-6-4-5-7-16(15)24/h4-11,17-19,25,27H,3,12H2,1-2H3 CLJUXOSYNIMXSO-UHFFFAOYSA-N 42294 1-(2-fluorophenyl)-3-(4-hydroxybenzyl)-4,6-diketo-5-methyl-1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3-carboxylic acid ethyl ester::1-(2-fluorophenyl)-3-[(4-hydroxyphenyl)methyl]-5-methyl-4,6-dioxo-1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3-carboxylic acid ethyl ester::3-(2-Fluoro-phenyl)-1-(4-hydroxy-benzyl)-5-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid ethyl ester::MLS000075228::SMR000006165::cid_656054::ethyl 1-(2-fluorophenyl)-3-[(4-hydroxyphenyl)methyl]-5-methyl-4,6-bis(oxidanylidene)-1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3-carboxylate::ethyl 1-(2-fluorophenyl)-3-[(4-hydroxyphenyl)methyl]-5-methyl-4,6-dioxo-1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3-carboxylate Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42294&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 656054 252622999 ZINC20150422 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79160 Cc1cc(C)cc(c1)N1CCN(CC1)C(=O)N1CCOCC1 InChI=1S/C17H25N3O2/c1-14-11-15(2)13-16(12-14)18-3-5-19(6-4-18)17(21)20-7-9-22-10-8-20/h11-13H,3-10H2,1-2H3 LNMNXZAVKYHJKL-UHFFFAOYSA-N 42295 MLS000034000::SMR000013789::[4-(3,5-Dimethyl-phenyl)-piperazin-1-yl]-morpholin-4-yl-methanone::[4-(3,5-dimethylphenyl)-1-piperazinyl]-(4-morpholinyl)methanone::[4-(3,5-dimethylphenyl)piperazin-1-yl]-morpholin-4-yl-methanone::[4-(3,5-dimethylphenyl)piperazin-1-yl]-morpholin-4-ylmethanone::[4-(3,5-dimethylphenyl)piperazino]-morpholino-methanone::cid_656229 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42295&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 656229 252623000 ZINC02709708 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79161 CCCCNC(=O)C1CCCN1C(=O)Nc1cccc(OC)c1 InChI=1S/C17H25N3O3/c1-3-4-10-18-16(21)15-9-6-11-20(15)17(22)19-13-7-5-8-14(12-13)23-2/h5,7-8,12,15H,3-4,6,9-11H2,1-2H3,(H,18,21)(H,19,22) QUPOBSOOZUZGRS-UHFFFAOYSA-N 42296 2-N-butyl-1-N-(3-methoxyphenyl)pyrrolidine-1,2-dicarboxamide::MLS000073932::N'-butyl-N-(3-methoxyphenyl)pyrrolidine-1,2-dicarboxamide::N2-butyl-N1-(3-methoxyphenyl)pyrrolidine-1,2-dicarboxamide::Pyrrolidine-1,2-dicarboxylic acid 2-butylamide 1-[(3-methoxy-phenyl)-amide]::SMR000006402::cid_656350 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42296&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 656350 252623001 ZINC04340467 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79162 Clc1ccccc1Cn1cnc2c(C#N)c3CCCCCn3c2c1=O InChI=1S/C19H17ClN4O/c20-15-7-4-3-6-13(15)11-23-12-22-17-14(10-21)16-8-2-1-5-9-24(16)18(17)19(23)25/h3-4,6-7,12H,1-2,5,8-9,11H2 BLKOYZFXPHZLKO-UHFFFAOYSA-N 42297 3-(2-chlorobenzyl)-4-keto-7,8,9,10-tetrahydro-6H-pyrimido[3,4]pyrrol[3,5-a]azepine-11-carbonitrile::3-[(2-chlorophenyl)methyl]-4-oxidanylidene-7,8,9,10-tetrahydro-6H-pyrimido[3,4]pyrrolo[3,5-a]azepine-11-carbonitrile::3-[(2-chlorophenyl)methyl]-4-oxo-7,8,9,10-tetrahydro-6H-pyrimido[3,4]pyrrolo[3,5-a]azepine-11-carbonitrile::MLS000038239::SMR000038693::cid_657822 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42297&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 657822 252623002 ZINC02256982 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79163 COC(=O)CN1C(=O)C2(OCCCO2)c2cc(Br)ccc12 InChI=1S/C14H14BrNO5/c1-19-12(17)8-16-11-4-3-9(15)7-10(11)14(13(16)18)20-5-2-6-21-14/h3-4,7H,2,5-6,8H2,1H3 MOBXWXRBAONHFS-UHFFFAOYSA-N 42298 2-(5'-bromo-2'-keto-spiro[1,3-dioxane-2,3'-indoline]-1'-yl)acetic acid methyl ester::2-(5'-bromo-2'-oxo-1'-spiro[1,3-dioxane-2,3'-indole]yl)acetic acid methyl ester::MLS000038210::SMR000036812::cid_658905::methyl 2-(5'-bromanyl-2'-oxidanylidene-spiro[1,3-dioxane-2,3'-indole]-1'-yl)ethanoate::methyl 2-(5'-bromo-2'-oxospiro[1,3-dioxane-2,3'-indole]-1'-yl)acetate Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42298&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 658905 252623003 ZINC03213416 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79164 C=CCn1c(n[nH]c1=S)-c1c[nH]c2ccccc12 InChI=1S/C13H12N4S/c1-2-7-17-12(15-16-13(17)18)10-8-14-11-6-4-3-5-9(10)11/h2-6,8,14H,1,7H2,(H,16,18) QYIMBZCZTCHWIH-UHFFFAOYSA-N 42299 (5Z)-4-allyl-5-indol-3-ylidene-1,2,4-triazolidine-3-thione::(5Z)-5-(3-indolylidene)-4-prop-2-enyl-1,2,4-triazolidine-3-thione::(5Z)-5-indol-3-ylidene-4-prop-2-enyl-1,2,4-triazolidine-3-thione::MLS000038259::SMR000034158::cid_5389222 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42299&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 5389222 252623004 ZINC17820210 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79165 CCC(C)NC(=O)c1c(N)n(CC2CCCO2)c2nc3ccccc3nc12 InChI=1S/C20H25N5O2/c1-3-12(2)22-20(26)16-17-19(24-15-9-5-4-8-14(15)23-17)25(18(16)21)11-13-7-6-10-27-13/h4-5,8-9,12-13H,3,6-7,10-11,21H2,1-2H3,(H,22,26) DNZJXEJASNLKKF-UHFFFAOYSA-N 30762 2-amino-N-butan-2-yl-1-(2-oxolanylmethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxamide::2-amino-N-butan-2-yl-1-(oxolan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-N-sec-butyl-1-(tetrahydrofurfuryl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-azanyl-N-butan-2-yl-1-(oxolan-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::MLS000040979::SMR000042875::cid_662288 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30762&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 662288 252615017 ZINC02265112 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79166 CC(C)Cn1c(N)c(C(=O)NCc2cccs2)c2nc3ccccc3nc12 InChI=1S/C20H21N5OS/c1-12(2)11-25-18(21)16(20(26)22-10-13-6-5-9-27-13)17-19(25)24-15-8-4-3-7-14(15)23-17/h3-9,12H,10-11,21H2,1-2H3,(H,22,26) QMIQLZBURIQOHA-UHFFFAOYSA-N 30765 2-amino-1-(2-methylpropyl)-N-(thiophen-2-ylmethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxamide::2-amino-1-(2-methylpropyl)-N-(thiophen-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-1-isobutyl-N-(2-thenyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-azanyl-1-(2-methylpropyl)-N-(thiophen-2-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::MLS000040877::SMR000043082::cid_662466 Lysosomal acid glucosylceramidase Homo sapiens 2490 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30765&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 662466 252615020 ZINC02397366 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79167 Cc1ccccc1OCC(=O)N(Cc1cccs1)C1CCS(=O)(=O)C1 InChI=1S/C18H21NO4S2/c1-14-5-2-3-7-17(14)23-12-18(20)19(11-16-6-4-9-24-16)15-8-10-25(21,22)13-15/h2-7,9,15H,8,10-13H2,1H3 QBMMXPBKICXZMV-UHFFFAOYSA-N 42300 MLS000042121::N-(1,1-diketothiolan-3-yl)-2-(2-methylphenoxy)-N-(2-thenyl)acetamide::N-(1,1-dioxo-3-thiolanyl)-2-(2-methylphenoxy)-N-(thiophen-2-ylmethyl)acetamide::N-(1,1-dioxothiolan-3-yl)-2-(2-methylphenoxy)-N-(thiophen-2-ylmethyl)acetamide::N-[1,1-bis(oxidanylidene)thiolan-3-yl]-2-(2-methylphenoxy)-N-(thiophen-2-ylmethyl)ethanamide::SMR000043236::cid_662623 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42300&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 662623 252623005 ZINC04313124 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79168 CC(C)OC(=O)CSc1nnc(-c2cccnc2)n1N InChI=1S/C12H15N5O2S/c1-8(2)19-10(18)7-20-12-16-15-11(17(12)13)9-4-3-5-14-6-9/h3-6,8H,7,13H2,1-2H3 WHSZCOMPIJHMGX-UHFFFAOYSA-N 42301 2-[[4-amino-5-(3-pyridinyl)-1,2,4-triazol-3-yl]thio]acetic acid propan-2-yl ester::2-[[4-amino-5-(3-pyridyl)-1,2,4-triazol-3-yl]thio]acetic acid isopropyl ester::MLS000039495::SMR000038059::cid_663179::propan-2-yl 2-[(4-amino-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetate::propan-2-yl 2-[(4-azanyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]ethanoate Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42301&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 663179 252623006 ZINC00531800 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79169 Cc1nc(SCC(=O)Nc2ccc3OCCOc3c2)c2oc3ccccc3c2n1 InChI=1S/C21H17N3O4S/c1-12-22-19-14-4-2-3-5-15(14)28-20(19)21(23-12)29-11-18(25)24-13-6-7-16-17(10-13)27-9-8-26-16/h2-7,10H,8-9,11H2,1H3,(H,24,25) FQBQPWNRPZORNL-UHFFFAOYSA-N 42302 MLS000041013::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(2-methyl-4-benzofuro[3,2-d]pyrimidinyl)thio]acetamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(2-methyl-[1]benzofuro[3,2-d]pyrimidin-4-yl)sulfanyl]acetamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(2-methyl-[1]benzofuro[3,2-d]pyrimidin-4-yl)sulfanyl]ethanamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(2-methylbenzofuro[3,2-d]pyrimidin-4-yl)thio]acetamide::SMR000044439::cid_663539 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42302&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 663539 252623007 ZINC02406761 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79170 Fc1cccc(NC(=O)CSc2ncnc3c4ccccc4oc23)c1 InChI=1S/C18H12FN3O2S/c19-11-4-3-5-12(8-11)22-15(23)9-25-18-17-16(20-10-21-18)13-6-1-2-7-14(13)24-17/h1-8,10H,9H2,(H,22,23) RJJVVEZXWHAYPD-UHFFFAOYSA-N 42303 2-(4-benzofuro[3,2-d]pyrimidinylthio)-N-(3-fluorophenyl)acetamide::2-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-fluorophenyl)acetamide::2-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-N-(3-fluorophenyl)ethanamide::2-(benzofuro[3,2-d]pyrimidin-4-ylthio)-N-(3-fluorophenyl)acetamide::MLS000039473::SMR000035236::cid_663542 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42303&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 663542 252623008 ZINC02406269 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79171 COc1ccc(cc1)S(=O)(=O)C(C#N)c1nc2ccccc2nc1N1CCCCC1 InChI=1S/C22H22N4O3S/c1-29-16-9-11-17(12-10-16)30(27,28)20(15-23)21-22(26-13-5-2-6-14-26)25-19-8-4-3-7-18(19)24-21/h3-4,7-12,20H,2,5-6,13-14H2,1H3 FSKSVPYYRDWVDD-UHFFFAOYSA-N 42304 2-(4-methoxyphenyl)sulfonyl-2-(3-piperidin-1-ylquinoxalin-2-yl)acetonitrile::2-(4-methoxyphenyl)sulfonyl-2-(3-piperidin-1-ylquinoxalin-2-yl)ethanenitrile::2-(4-methoxyphenyl)sulfonyl-2-(3-piperidinoquinoxalin-2-yl)acetonitrile::2-(4-methoxyphenyl)sulfonyl-2-[3-(1-piperidinyl)-2-quinoxalinyl]acetonitrile::MLS000040987::SMR000045024::cid_664159 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42304&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 664159 252623009 ZINC02343678 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79172 CCC(C)n1cnc2n(Cc3ccc4OCOc4c3)c3nc4ccccc4nc3c2c1=O InChI=1S/C24H21N5O3/c1-3-14(2)29-12-25-22-20(24(29)30)21-23(27-17-7-5-4-6-16(17)26-21)28(22)11-15-8-9-18-19(10-15)32-13-31-18/h4-10,12,14H,3,11,13H2,1-2H3 QXTXPYIICNLTBY-UHFFFAOYSA-N 42305 MLS000041040::SMR000045696::cid_664650 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42305&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 664650 242053018 ZINC02427265 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79173 Cc1cc(C)nc(Sc2nc(C)nc3c4ccccc4oc23)n1 InChI=1S/C17H14N4OS/c1-9-8-10(2)19-17(18-9)23-16-15-14(20-11(3)21-16)12-6-4-5-7-13(12)22-15/h4-8H,1-3H3 CICQPJKIXQLROH-UHFFFAOYSA-N 42306 4-(4,6-dimethylpyrimidin-2-yl)sulfanyl-2-methyl-[1]benzofuro[3,2-d]pyrimidine::4-[(4,6-dimethyl-2-pyrimidinyl)thio]-2-methylbenzofuro[3,2-d]pyrimidine::4-[(4,6-dimethylpyrimidin-2-yl)thio]-2-methyl-benzofuro[3,2-d]pyrimidine::MLS000082663::SMR000046175::cid_665080 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42306&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 665080 252623010 ZINC02454122 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79174 CCOc1ccc(cc1OCC)-c1noc(n1)-c1ccncc1 InChI=1S/C17H17N3O3/c1-3-21-14-6-5-13(11-15(14)22-4-2)16-19-17(23-20-16)12-7-9-18-10-8-12/h5-11H,3-4H2,1-2H3 SDQKDGIXTOSJJL-UHFFFAOYSA-N 36953 3-(3,4-diethoxyphenyl)-5-(4-pyridyl)-1,2,4-oxadiazole::3-(3,4-diethoxyphenyl)-5-pyridin-4-yl-1,2,4-oxadiazole::MLS000042464::SMR000047734::US10544136, Compound 257::cid_666359 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36953&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 666359 252617925 ZINC02218737 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79175 C(Sc1nnc(-c2ccco2)n1Cc1ccccc1)c1nc2ccccc2s1 InChI=1S/C21H16N4OS2/c1-2-7-15(8-3-1)13-25-20(17-10-6-12-26-17)23-24-21(25)27-14-19-22-16-9-4-5-11-18(16)28-19/h1-12H,13-14H2 CXJQOMGZPJXBQP-UHFFFAOYSA-N 42307 2-[[4-benzyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-benzothiazole::2-[[5-(furan-2-yl)-4-(phenylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-1,3-benzothiazole::2-[[[4-benzyl-5-(2-furyl)-1,2,4-triazol-3-yl]thio]methyl]-1,3-benzothiazole::2-[[[5-(2-furanyl)-4-(phenylmethyl)-1,2,4-triazol-3-yl]thio]methyl]-1,3-benzothiazole::MLS000096502::SMR000062307::cid_2386422 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42307&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2386422 252623011 ZINC03270112 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79176 CCCc1cc(=O)[nH]c(SCC(=O)CSc2nc(CCC)cc(=O)[nH]2)n1 InChI=1S/C17H22N4O3S2/c1-3-5-11-7-14(23)20-16(18-11)25-9-13(22)10-26-17-19-12(6-4-2)8-15(24)21-17/h7-8H,3-6,9-10H2,1-2H3,(H,18,20,23)(H,19,21,24) RAFHALUWXUJNGM-UHFFFAOYSA-N 42308 2-[2-oxidanylidene-3-[(4-oxidanylidene-6-propyl-1H-pyrimidin-2-yl)sulfanyl]propyl]sulfanyl-6-propyl-1H-pyrimidin-4-one::2-[2-oxo-3-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)sulfanyl]propyl]sulfanyl-6-propyl-1H-pyrimidin-4-one::2-[[2-keto-3-[(4-keto-6-propyl-1H-pyrimidin-2-yl)thio]propyl]thio]-6-propyl-1H-pyrimidin-4-one::2-[[2-oxo-3-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)thio]propyl]thio]-6-propyl-1H-pyrimidin-4-one::MLS000057786::SMR000061797::cid_2402619 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42308&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2402619 252623012 ZINC18169259 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79177 Cc1ccc(C)n1-c1ccc(cc1)C(=O)NCC1CCCO1 InChI=1S/C18H22N2O2/c1-13-5-6-14(2)20(13)16-9-7-15(8-10-16)18(21)19-12-17-4-3-11-22-17/h5-10,17H,3-4,11-12H2,1-2H3,(H,19,21) DHEPPVNJDMMDEU-UHFFFAOYSA-N 42309 4-(2,5-dimethyl-1-pyrrolyl)-N-(2-oxolanylmethyl)benzamide::4-(2,5-dimethylpyrrol-1-yl)-N-(oxolan-2-ylmethyl)benzamide::4-(2,5-dimethylpyrrol-1-yl)-N-(tetrahydrofurfuryl)benzamide::MLS000057684::SMR000067790::cid_2998371 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42309&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2998371 252623013 ZINC00194156 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79178 CCCCOc1nc2ccccc2nc1C(C#N)S(=O)(=O)c1ccccc1 InChI=1S/C20H19N3O3S/c1-2-3-13-26-20-19(22-16-11-7-8-12-17(16)23-20)18(14-21)27(24,25)15-9-5-4-6-10-15/h4-12,18H,2-3,13H2,1H3 IBDCCLWQMGOTKO-UHFFFAOYSA-N 41312 2-(3-butoxyquinoxalin-2-yl)-2-(phenylsulfonyl)ethanenitrile::2-(benzenesulfonyl)-2-(3-butoxy-2-quinoxalinyl)acetonitrile::2-(benzenesulfonyl)-2-(3-butoxyquinoxalin-2-yl)acetonitrile::2-besyl-2-(3-butoxyquinoxalin-2-yl)acetonitrile::MLS000048714::SMR000060258::cid_2998732 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41312&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2998732 252622081 ZINC03137167 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79179 CN(CC1COc2ccccc2O1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4O2/c1-27(14-17-15-28-20-10-4-5-11-21(20)29-17)23-18-8-2-3-9-19(18)25-22(26-23)16-7-6-12-24-13-16/h2-13,17H,14-15H2,1H3 JFOVNJQCUHRYOI-UHFFFAOYSA-N 42310 2,3-dihydro-1,4-benzodioxin-3-ylmethyl-methyl-[2-(3-pyridyl)quinazolin-4-yl]amine::MLS000058502::N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-N-methyl-2-(3-pyridinyl)-4-quinazolinamine::N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-N-methyl-2-pyridin-3-yl-quinazolin-4-amine::N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-N-methyl-2-pyridin-3-ylquinazolin-4-amine::SMR000068089::US10167270, Example 3::cid_2999577 Lysosomal acid glucosylceramidase Homo sapiens 2649 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42310&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2999577 252623014 ZINC03408467 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79180 COc1ccc2N(C(C)=O)S(=O)(=O)c3ccccc3-c2c1 InChI=1S/C15H13NO4S/c1-10(17)16-14-8-7-11(20-2)9-13(14)12-5-3-4-6-15(12)21(16,18)19/h3-9H,1-2H3 QWHQYEJDFKFBFC-UHFFFAOYSA-N 38381 1-(5,5-diketo-9-methoxy-benzo[c][1,2]benzothiazin-6-yl)ethanone::1-(9-methoxy-5,5-dioxo-6-benzo[c][1,2]benzothiazinyl)ethanone::1-(9-methoxy-5,5-dioxobenzo[c][1,2]benzothiazin-6-yl)ethanone::1-[9-methoxy-5,5-bis(oxidanylidene)benzo[c][1,2]benzothiazin-6-yl]ethanone::MLS000048564::SMR000060465::cid_2314340 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=38381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=38381&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2314340 252619293 ZINC03179179 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79181 Cc1ccc(cc1)C(N1CCCC1)C(=O)NC1CCCCC1 InChI=1S/C19H28N2O/c1-15-9-11-16(12-10-15)18(21-13-5-6-14-21)19(22)20-17-7-3-2-4-8-17/h9-12,17-18H,2-8,13-14H2,1H3,(H,20,22) IWLNQHMTSAKSQU-UHFFFAOYSA-N 42311 MLS000044160::N-cyclohexyl-2-(4-methylphenyl)-2-(1-pyrrolidinyl)acetamide::N-cyclohexyl-2-(4-methylphenyl)-2-pyrrolidin-1-yl-ethanamide::N-cyclohexyl-2-(4-methylphenyl)-2-pyrrolidin-1-ylacetamide::N-cyclohexyl-2-(p-tolyl)-2-pyrrolidino-acetamide::SMR000021944::cid_3235603 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42311&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3235603 252623015 ZINC58012621 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79182 Cc1nonc1NC(=O)OCCN1CCOC1=O InChI=1S/C9H12N4O5/c1-6-7(12-18-11-6)10-8(14)16-4-2-13-3-5-17-9(13)15/h2-5H2,1H3,(H,10,12,14) QZOGRYWPHNETAH-UHFFFAOYSA-N 42312 2-(2-oxidanylidene-1,3-oxazolidin-3-yl)ethyl N-(4-methyl-1,2,5-oxadiazol-3-yl)carbamate::2-(2-oxo-1,3-oxazolidin-3-yl)ethyl 4-methyl-1,2,5-oxadiazol-3-ylcarbamate::2-(2-oxo-1,3-oxazolidin-3-yl)ethyl N-(4-methyl-1,2,5-oxadiazol-3-yl)carbamate::MLS000087752::N-(4-methyl-1,2,5-oxadiazol-3-yl)carbamic acid 2-(2-oxo-3-oxazolidinyl)ethyl ester::N-(4-methylfurazan-3-yl)carbamic acid 2-(2-ketooxazolidin-3-yl)ethyl ester::SMR000023973::cid_3235724 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42312&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3235724 252623016 ZINC03169274 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79183 COc1ccc(CNC(=O)CCCNS(=O)(=O)c2cccc3nonc23)cc1 InChI=1S/C18H20N4O5S/c1-26-14-9-7-13(8-10-14)12-19-17(23)6-3-11-20-28(24,25)16-5-2-4-15-18(16)22-27-21-15/h2,4-5,7-10,20H,3,6,11-12H2,1H3,(H,19,23) IQDOVHXGXXVXLW-UHFFFAOYSA-N 42313 4-(2,1,3-benzoxadiazol-4-ylsulfonylamino)-N-[(4-methoxyphenyl)methyl]butanamide::4-(benzofurazan-4-ylsulfonylamino)-N-p-anisyl-butyramide::4-[(2,1,3-benzoxadiazol-4-ylsulfonyl)amino]-N-(4-methoxybenzyl)butanamide::MLS000044389::SMR000022166::cid_3235729 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42313&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3235729 252623017 ZINC03665276 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79184 CN(C)c1ccc(cc1)-c1nc2ccccc2n1C InChI=1S/C16H17N3/c1-18(2)13-10-8-12(9-11-13)16-17-14-6-4-5-7-15(14)19(16)3/h4-11H,1-3H3 UPHHTAKTKIWBHH-UHFFFAOYSA-N 38084 MLS000089904::N,N-dimethyl-4-(1-methyl-2-benzimidazolyl)aniline::N,N-dimethyl-4-(1-methylbenzimidazol-2-yl)aniline::N,N-dimethyl-N-[4-(1-methyl-1H-benzimidazol-2-yl)phenyl]amine::SMR000024522::cid_744236::dimethyl-[4-(1-methylbenzimidazol-2-yl)phenyl]amine Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=38084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=38084&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 744236 252619035 ZINC00184673 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79185 Brc1ccc(cc1)S(=O)(=O)CCC(=O)N1CCN(Cc2ccccc2)CC1 InChI=1S/C20H23BrN2O3S/c21-18-6-8-19(9-7-18)27(25,26)15-10-20(24)23-13-11-22(12-14-23)16-17-4-2-1-3-5-17/h1-9H,10-16H2 GPEYEMBWUWQEQE-UHFFFAOYSA-N 42314 1-(4-benzylpiperazin-1-yl)-3-(4-bromophenyl)sulfonylpropan-1-one::1-(4-benzylpiperazino)-3-brosyl-propan-1-one::1-benzyl-4-{3-[(4-bromophenyl)sulfonyl]propanoyl}piperazine::3-(4-bromophenyl)sulfonyl-1-[4-(phenylmethyl)-1-piperazinyl]-1-propanone::3-(4-bromophenyl)sulfonyl-1-[4-(phenylmethyl)piperazin-1-yl]propan-1-one::MLS000047531::SMR000033542::cid_3235946 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42314&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3235946 252623018 ZINC20768524 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79186 CC1=Nc2nc(nn2C(C1C(N)=O)c1cccs1)-c1cccc(C)c1 InChI=1S/C18H17N5OS/c1-10-5-3-6-12(9-10)17-21-18-20-11(2)14(16(19)24)15(23(18)22-17)13-7-4-8-25-13/h3-9,14-15H,1-2H3,(H2,19,24) KJOBGLWATYZABS-UHFFFAOYSA-N 42315 5-methyl-2-(3-methylphenyl)-7-thien-2-yl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide::5-methyl-2-(3-methylphenyl)-7-thiophen-2-yl-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide::5-methyl-2-(m-tolyl)-7-(2-thienyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide::MLS000043149::SMR000019576::cid_5771278 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42315&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 75843670 252623019 ZINC13123752 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79187 COC(=O)c1cn(NC(=O)c2ccncc2)c(=O)c2ccccc12 InChI=1S/C17H13N3O4/c1-24-17(23)14-10-20(16(22)13-5-3-2-4-12(13)14)19-15(21)11-6-8-18-9-7-11/h2-10H,1H3,(H,19,21) HWFOIJNQCSTWFJ-UHFFFAOYSA-N 42316 1-oxo-2-[[oxo(pyridin-4-yl)methyl]amino]-4-isoquinolinecarboxylic acid methyl ester::2-isonicotinamido-1-keto-isoquinoline-4-carboxylic acid methyl ester::MLS000044460::SMR000022237::cid_3236069::methyl 1-oxidanylidene-2-(pyridin-4-ylcarbonylamino)isoquinoline-4-carboxylate::methyl 1-oxo-2-(pyridine-4-carbonylamino)isoquinoline-4-carboxylate::methyl 2-(isonicotinoylamino)-1-oxo-1,2-dihydroisoquinoline-4-carboxylate Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42316&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3236069 252623020 ZINC00213023 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79188 CC1CCCCN1C(=O)CSc1nc2cc3OCOc3cc2c(=O)n1Cc1ccc2OCOc2c1 InChI=1S/C25H25N3O6S/c1-15-4-2-3-7-27(15)23(29)12-35-25-26-18-10-22-21(33-14-34-22)9-17(18)24(30)28(25)11-16-5-6-19-20(8-16)32-13-31-19/h5-6,8-10,15H,2-4,7,11-14H2,1H3 SUORGWHDGSHGDV-UHFFFAOYSA-N 42317 6-[[2-keto-2-(2-methylpiperidino)ethyl]thio]-7-piperonyl-[1,3]dioxolo[4,5-g]quinazolin-8-one::7-(1,3-benzodioxol-5-ylmethyl)-6-[2-(2-methylpiperidin-1-yl)-2-oxidanylidene-ethyl]sulfanyl-[1,3]dioxolo[4,5-g]quinazolin-8-one::7-(1,3-benzodioxol-5-ylmethyl)-6-[2-(2-methylpiperidin-1-yl)-2-oxoethyl]sulfanyl-[1,3]dioxolo[4,5-g]quinazolin-8-one::7-(1,3-benzodioxol-5-ylmethyl)-6-[[2-(2-methyl-1-piperidinyl)-2-oxoethyl]thio]-[1,3]dioxolo[4,5-g]quinazolin-8-one::7-(1,3-benzodioxol-5-ylmethyl)-6-{[2-(2-methylpiperidin-1-yl)-2-oxoethyl]thio}[1,3]dioxolo[4,5-g]quinazolin-8(7H)-one::MLS000095409::SMR000030963::cid_3236102 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42317&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3236102 252623021 ZINC04142490 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79189 CCN1CCN(CCCNC(=O)c2cc3cc4ccc(OC)cc4nc3o2)CC1 InChI=1S/C22H28N4O3/c1-3-25-9-11-26(12-10-25)8-4-7-23-21(27)20-14-17-13-16-5-6-18(28-2)15-19(16)24-22(17)29-20/h5-6,13-15H,3-4,7-12H2,1-2H3,(H,23,27) NBLIKKSFJBCIBN-UHFFFAOYSA-N 42318 MLS000091920::N-[3-(4-ethyl-1-piperazinyl)propyl]-7-methoxy-2-furo[2,3-b]quinolinecarboxamide::N-[3-(4-ethylpiperazin-1-yl)propyl]-7-methoxy-furo[2,3-b]quinoline-2-carboxamide::N-[3-(4-ethylpiperazin-1-yl)propyl]-7-methoxyfuro[2,3-b]quinoline-2-carboxamide::N-[3-(4-ethylpiperazino)propyl]-7-methoxy-furo[2,3-b]quinoline-2-carboxamide::SMR000026444::cid_3236194 Lysosomal acid glucosylceramidase Homo sapiens 15890 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42318&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3236194 252623022 ZINC20210089 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79190 COc1cc2c(cn(C)c(=O)c2cc1OC)C(=O)NCCCN1CCN(CC1)c1cccc(Cl)c1 InChI=1S/C26H31ClN4O4/c1-29-17-22(20-15-23(34-2)24(35-3)16-21(20)26(29)33)25(32)28-8-5-9-30-10-12-31(13-11-30)19-7-4-6-18(27)14-19/h4,6-7,14-17H,5,8-13H2,1-3H3,(H,28,32) KHBDOWSBWWBBSN-UHFFFAOYSA-N 42319 MLS000044596::N-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-6,7-dimethoxy-2-methyl-1-oxo-4-isoquinolinecarboxamide::N-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-6,7-dimethoxy-2-methyl-1-oxidanylidene-isoquinoline-4-carboxamide::N-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-6,7-dimethoxy-2-methyl-1-oxoisoquinoline-4-carboxamide::N-[3-[4-(3-chlorophenyl)piperazino]propyl]-1-keto-6,7-dimethoxy-2-methyl-isoquinoline-4-carboxamide::N-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-6,7-dimethoxy-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide::SMR000022541::cid_3236581 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42319&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3236581 252623023 ZINC04057597 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79191 CCOc1ccccc1CNS(=O)(=O)c1ccc2[nH]c(=O)sc2c1 InChI=1S/C16H16N2O4S2/c1-2-22-14-6-4-3-5-11(14)10-17-24(20,21)12-7-8-13-15(9-12)23-16(19)18-13/h3-9,17H,2,10H2,1H3,(H,18,19) SHMPGIRVFRFQBK-UHFFFAOYSA-N 42320 MLS000090517::N-(2-ethoxybenzyl)-2-keto-3H-1,3-benzothiazole-6-sulfonamide::N-(2-ethoxybenzyl)-2-oxo-2,3-dihydro-1,3-benzothiazole-6-sulfonamide::N-[(2-ethoxyphenyl)methyl]-2-oxidanylidene-3H-1,3-benzothiazole-6-sulfonamide::N-[(2-ethoxyphenyl)methyl]-2-oxo-3H-1,3-benzothiazole-6-sulfonamide::SMR000025121::cid_3236973 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42320&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3236973 252623024 ZINC06498225 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79192 COc1cccc(c1)N1C(=O)Nc2ccccc2C1(O)C(=O)NCc1ccc2OCOc2c1 InChI=1S/C24H21N3O6/c1-31-17-6-4-5-16(12-17)27-23(29)26-19-8-3-2-7-18(19)24(27,30)22(28)25-13-15-9-10-20-21(11-15)33-14-32-20/h2-12,30H,13-14H2,1H3,(H,25,28)(H,26,29) JATGXQNRXIMVFM-UHFFFAOYSA-N 42321 4-hydroxy-2-keto-3-(3-methoxyphenyl)-N-piperonyl-1H-quinazoline-4-carboxamide::MLS000044406::N-(1,3-benzodioxol-5-ylmethyl)-3-(3-methoxyphenyl)-4-oxidanyl-2-oxidanylidene-1H-quinazoline-4-carboxamide::N-(1,3-benzodioxol-5-ylmethyl)-4-hydroxy-3-(3-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydroquinazoline-4-carboxamide::N-(1,3-benzodioxol-5-ylmethyl)-4-hydroxy-3-(3-methoxyphenyl)-2-oxo-1H-quinazoline-4-carboxamide::SMR000022183::cid_3237045 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42321&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3237045 252623025 ZINC03665894 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79193 Cc1ccccc1NC(=O)Nc1cccs1 InChI=1S/C12H12N2OS/c1-9-5-2-3-6-10(9)13-12(15)14-11-7-4-8-16-11/h2-8H,1H3,(H2,13,14,15) RMWRICZCLIVQNF-UHFFFAOYSA-N 42322 1-(2-methylphenyl)-3-thiophen-2-yl-urea::1-(2-methylphenyl)-3-thiophen-2-ylurea::1-(o-tolyl)-3-(2-thienyl)urea::MLS000093630::N-(2-methylphenyl)-N'-thien-2-ylurea::SMR000029248::cid_3237082 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42322&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3237082 252623026 ZINC04111642 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79194 CC(=O)c1ccc2Sc3ccccc3Nc2c1 InChI=1S/C14H11NOS/c1-9(16)10-6-7-14-12(8-10)15-11-4-2-3-5-13(11)17-14/h2-8,15H,1H3 JWGBOHJGWOPYCL-UHFFFAOYSA-N 42323 1-(10H-phenothiazin-2-yl)ethanone::MLS000047624::SMR000033635::cid_81131 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42323&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 81131 252623027 ZINC00119687 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79195 OC(=O)c1ccc2C(=O)OC(c2c1)c1ccccc1 InChI=1S/C15H10O4/c16-14(17)10-6-7-11-12(8-10)13(19-15(11)18)9-4-2-1-3-5-9/h1-8,13H,(H,16,17) LDNVHPNRWHQLFG-UHFFFAOYSA-N 42324 1-keto-3-phenyl-phthalan-5-carboxylic acid::1-oxidanylidene-3-phenyl-3H-2-benzofuran-5-carboxylic acid::1-oxo-3-phenyl-1,3-dihydro-2-benzofuran-5-carboxylic acid::1-oxo-3-phenyl-3H-2-benzofuran-5-carboxylic acid::1-oxo-3-phenyl-3H-isobenzofuran-5-carboxylic acid::MLS000085193::SMR000019733::cid_3237238 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42324&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3237238 252623028 ZINC00204793 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79196 CC1=Nc2nnnn2C(C1C(=O)Nc1cccnc1)c1ccncc1 InChI=1S/C16H14N8O/c1-10-13(15(25)20-12-3-2-6-18-9-12)14(11-4-7-17-8-5-11)24-16(19-10)21-22-23-24/h2-9,13-14H,1H3,(H,20,25) QGQAVEGTYWNIPM-UHFFFAOYSA-N 42325 5-methyl-N-(3-pyridinyl)-7-pyridin-4-yl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide::5-methyl-N-(3-pyridyl)-7-(4-pyridyl)-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide::5-methyl-N-pyridin-3-yl-7-pyridin-4-yl-1,7-dihydro-[1,2,3,4]tetrazolo[1,5-a]pyrimidine-6-carboxamide::5-methyl-N-pyridin-3-yl-7-pyridin-4-yl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide::5-methyl-N-pyridin-3-yl-7-pyridin-4-yl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide::MLS000085171::SMR000019711::cid_5771319 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42325&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 91896531 252623029 ZINC13123694 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79197 CCN(CC)c1nc2cc(OC)ccc2cc1C#N InChI=1S/C15H17N3O/c1-4-18(5-2)15-12(10-16)8-11-6-7-13(19-3)9-14(11)17-15/h6-9H,4-5H2,1-3H3 MZVWXJBRVLHBPD-UHFFFAOYSA-N 42326 2-(diethylamino)-7-methoxy-3-quinolinecarbonitrile::2-(diethylamino)-7-methoxy-quinoline-3-carbonitrile::2-(diethylamino)-7-methoxyquinoline-3-carbonitrile::MLS000086235::SMR000021744::cid_3237518 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42326&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3237518 252623030 ZINC19801417 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79198 COCc1nnc(NC(=O)c2ccc(cc2)S(=O)(=O)N(C)C2CCCCC2)o1 InChI=1S/C18H24N4O5S/c1-22(14-6-4-3-5-7-14)28(24,25)15-10-8-13(9-11-15)17(23)19-18-21-20-16(27-18)12-26-2/h8-11,14H,3-7,12H2,1-2H3,(H,19,21,23) XJSRTQUZHVMKGP-UHFFFAOYSA-N 42327 4-[cyclohexyl(methyl)sulfamoyl]-N-[5-(methoxymethyl)-1,3,4-oxadiazol-2-yl]benzamide::4-{[cyclohexyl(methyl)amino]sulfonyl}-N-[5-(methoxymethyl)-1,3,4-oxadiazol-2-yl]benzamide::MLS000086355::SMR000021857::cid_2051224 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42327&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2051224 252623031 ZINC02457004 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79199 CN(CC(=O)Nc1nc2c(C)cccc2s1)S(=O)(=O)c1cccs1 InChI=1S/C15H15N3O3S3/c1-10-5-3-6-11-14(10)17-15(23-11)16-12(19)9-18(2)24(20,21)13-7-4-8-22-13/h3-8H,9H2,1-2H3,(H,16,17,19) OHLVECCCMAOXAY-UHFFFAOYSA-N 42328 MLS000090570::N-(4-methyl-1,3-benzothiazol-2-yl)-2-[methyl(2-thienylsulfonyl)amino]acetamide::N-(4-methyl-1,3-benzothiazol-2-yl)-2-[methyl(thiophen-2-ylsulfonyl)amino]acetamide::N-(4-methyl-1,3-benzothiazol-2-yl)-2-[methyl(thiophen-2-ylsulfonyl)amino]ethanamide::N~2~-methyl-N~1~-(4-methyl-1,3-benzothiazol-2-yl)-N~2~-(thien-2-ylsulfonyl)glycinamide::SMR000025174::cid_3238093 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42328&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3238093 252623032 ZINC04104167 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79200 O=C(CCCn1c(=S)[nH]c2cc3OCOc3cc2c1=O)N1CCN(CC1)c1ncccn1 InChI=1S/C21H22N6O4S/c28-18(25-7-9-26(10-8-25)20-22-4-2-5-23-20)3-1-6-27-19(29)14-11-16-17(31-13-30-16)12-15(14)24-21(27)32/h2,4-5,11-12H,1,3,6-10,13H2,(H,24,32) NBKXNQXSPSYIFA-UHFFFAOYSA-N 42329 7-[4-keto-4-[4-(2-pyrimidyl)piperazino]butyl]-6-thioxo-5H-[1,3]dioxolo[4,5-g]quinazolin-8-one::7-[4-oxidanylidene-4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-6-sulfanylidene-5H-[1,3]dioxolo[4,5-g]quinazolin-8-one::7-[4-oxo-4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-6-sulfanylidene-5H-[1,3]dioxolo[4,5-g]quinazolin-8-one::7-[4-oxo-4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-6-thioxo-6,7-dihydro[1,3]dioxolo[4,5-g]quinazolin-8(5H)-one::7-[4-oxo-4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-6-sulfanylidene-5H-[1,3]dioxolo[4,5-g]quinazolin-8-one::MLS000095372::SMR000030926::cid_3238158 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42329&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3238158 252623033 ZINC02975285 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79201 COC(=O)CN1CCN(C(=O)c2ccc(F)cc2)c2ccccc2C1 InChI=1S/C19H19FN2O3/c1-25-18(23)13-21-10-11-22(17-5-3-2-4-15(17)12-21)19(24)14-6-8-16(20)9-7-14/h2-9H,10-13H2,1H3 AKAHDSWAKABNAX-UHFFFAOYSA-N 42330 2-[1-(4-fluorobenzoyl)-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetic acid methyl ester::2-[1-[(4-fluorophenyl)-oxomethyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetic acid methyl ester::MLS000047188::SMR000033199::cid_3238205::methyl 2-[1-(4-fluorobenzoyl)-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetate::methyl 2-[1-(4-fluorophenyl)carbonyl-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]ethanoate::methyl [1-(4-fluorobenzoyl)-1,2,3,5-tetrahydro-4H-1,4-benzodiazepin-4-yl]acetate Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42330&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3238205 252623034 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79202 CN(C)CCCNC(=O)C1(O)N(C(=O)Nc2ccc(Br)cc12)c1ccc(C)c(C)c1 InChI=1S/C22H27BrN4O3/c1-14-6-8-17(12-15(14)2)27-21(29)25-19-9-7-16(23)13-18(19)22(27,30)20(28)24-10-5-11-26(3)4/h6-9,12-13,30H,5,10-11H2,1-4H3,(H,24,28)(H,25,29) UNVZFPAVCQIWCI-UHFFFAOYSA-N 42331 6-bromanyl-N-[3-(dimethylamino)propyl]-3-(3,4-dimethylphenyl)-4-oxidanyl-2-oxidanylidene-1H-quinazoline-4-carboxamide::6-bromo-N-[3-(dimethylamino)propyl]-3-(3,4-dimethylphenyl)-4-hydroxy-2-keto-1H-quinazoline-4-carboxamide::6-bromo-N-[3-(dimethylamino)propyl]-3-(3,4-dimethylphenyl)-4-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazoline-4-carboxamide::6-bromo-N-[3-(dimethylamino)propyl]-3-(3,4-dimethylphenyl)-4-hydroxy-2-oxo-1H-quinazoline-4-carboxamide::MLS000044427::SMR000022204::cid_3238244 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42331&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3238244 252623035 ZINC03670626 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79203 Cc1ccc(cc1)-n1c2nc3ccccn3c(=O)c2cc(C#N)c1=O InChI=1S/C19H12N4O2/c1-12-5-7-14(8-6-12)23-17-15(10-13(11-20)18(23)24)19(25)22-9-3-2-4-16(22)21-17/h2-10H,1H3 GZLZCHMVYKPCEN-UHFFFAOYSA-N 30856 1-(4-methylphenyl)-2,5-bis(oxidanylidene)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carbonitrile::1-(4-methylphenyl)-2,5-dioxo-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carbonitrile::1-(4-methylphenyl)-2,5-dioxo-3-dipyrido[1,2-d:3',4'-f]pyrimidinecarbonitrile::1-(4-methylphenyl)-2,5-dioxodipyrido[1,2-d:3',4'-f]pyrimidine-3-carbonitrile::2,5-diketo-1-(p-tolyl)dipyrido[1,2-d:3',4'-f]pyrimidine-3-carbonitrile::MLS000094257::SMR000029847::cid_3238489 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30856&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3238489 252615111 ZINC04102065 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79204 CCOC(=O)C1CCN(CC1)C(=O)c1ccc(NC(=O)C2CCCO2)cc1 InChI=1S/C20H26N2O5/c1-2-26-20(25)15-9-11-22(12-10-15)19(24)14-5-7-16(8-6-14)21-18(23)17-4-3-13-27-17/h5-8,15,17H,2-4,9-13H2,1H3,(H,21,23) XHTRLCPNADNBMI-UHFFFAOYSA-N 42332 1-[4-(tetrahydrofuran-2-carbonylamino)benzoyl]isonipecotic acid ethyl ester::1-[oxo-[4-[[oxo(2-oxolanyl)methyl]amino]phenyl]methyl]-4-piperidinecarboxylic acid ethyl ester::MLS000086690::SMR000022730::cid_3238537::ethyl 1-[4-(oxolan-2-ylcarbonylamino)phenyl]carbonylpiperidine-4-carboxylate::ethyl 1-[4-(oxolane-2-carbonylamino)benzoyl]piperidine-4-carboxylate::ethyl 1-{4-[(tetrahydrofuran-2-ylcarbonyl)amino]benzoyl}piperidine-4-carboxylate Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42332&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3238537 252623036 ZINC03906280 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79205 CCOC(=O)NC(CC(O)=O)c1ccc(OCC)cc1 InChI=1S/C14H19NO5/c1-3-19-11-7-5-10(6-8-11)12(9-13(16)17)15-14(18)20-4-2/h5-8,12H,3-4,9H2,1-2H3,(H,15,18)(H,16,17) OCTNDBSGMSWZKY-UHFFFAOYSA-N 42333 3-(carbethoxyamino)-3-p-phenetyl-propionic acid::3-(ethoxycarbonylamino)-3-(4-ethoxyphenyl)propanoic acid::3-[(ethoxycarbonyl)amino]-3-(4-ethoxyphenyl)propanoic acid::MLS000087735::SMR000023956::cid_3238651 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42333&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3238651 252623037 ZINC04101959 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544544 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 8.20 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544545 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 1.70 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544546 CCCC1(CCC)NC[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C12H25NO3/c1-3-5-12(6-4-2)9(8-14)11(16)10(15)7-13-12/h9-11,13-16H,3-8H2,1-2H3/t9-,10-,11-/m1/s1 GZJQITPDATVFSD-GMTAPVOTSA-N 285817 US10081601, Example 1.2::US9796680, Example Table2.2 Lysosomal acid glucosylceramidase Homo sapiens 1400 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285817&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197601 378169454 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544547 CC1(C)NC[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C8H17NO3/c1-8(2)5(4-10)7(12)6(11)3-9-8/h5-7,9-12H,3-4H2,1-2H3/t5-,6-,7-/m1/s1 VQHFRRBJUIUVOE-FSDSQADBSA-N 285818 US10081601, Example 1.3::US9796680, Example Table2.3 Lysosomal acid glucosylceramidase Homo sapiens 222 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285818&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197651 378169455 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544548 C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C8H15NO2/c1-5-7(11)6(10)4-9-8(5)2-3-8/h5-7,9-11H,2-4H2,1H3/t5-,6-,7-/m1/s1 SNBKQXWAMBQGSA-FSDSQADBSA-N 285819 (6R,7R,8S)-8-methyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 1::US9796680, Example 1 Lysosomal acid glucosylceramidase Homo sapiens 3.70 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285819&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197630 378169456 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544549 C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C8H15NO2/c1-5-7(11)6(10)4-9-8(5)2-3-8/h5-7,9-11H,2-4H2,1H3/t5-,6-,7-/m1/s1 SNBKQXWAMBQGSA-FSDSQADBSA-N 285819 (6R,7R,8S)-8-methyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 1::US9796680, Example 1 Lysosomal acid glucosylceramidase Homo sapiens 2.60 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285819&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197630 378169456 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544550 OC[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C8H15NO3/c10-4-5-7(12)6(11)3-9-8(5)1-2-8/h5-7,9-12H,1-4H2/t5-,6-,7-/m1/s1 UVWFVBWKBBONDJ-FSDSQADBSA-N 285820 (6R,7R,8R)-8-(hydroxymethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 2::US9796680, Example 2 Lysosomal acid glucosylceramidase Homo sapiens 13.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285820&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197685 378169457 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79206 COc1ccc(NC(=O)CN2CCN(CC2)S(=O)(=O)c2ccc(cc2)C(C)C)cc1OC InChI=1S/C23H31N3O5S/c1-17(2)18-5-8-20(9-6-18)32(28,29)26-13-11-25(12-14-26)16-23(27)24-19-7-10-21(30-3)22(15-19)31-4/h5-10,15,17H,11-14,16H2,1-4H3,(H,24,27) CQOVPDOZPIPSDJ-UHFFFAOYSA-N 42334 MLS000047486::N-(3,4-dimethoxyphenyl)-2-(4-p-cumenylsulfonylpiperazino)acetamide::N-(3,4-dimethoxyphenyl)-2-[4-(4-propan-2-ylphenyl)sulfonyl-1-piperazinyl]acetamide::N-(3,4-dimethoxyphenyl)-2-[4-(4-propan-2-ylphenyl)sulfonylpiperazin-1-yl]acetamide::N-(3,4-dimethoxyphenyl)-2-[4-(4-propan-2-ylphenyl)sulfonylpiperazin-1-yl]ethanamide::N-(3,4-dimethoxyphenyl)-2-{4-[(4-isopropylphenyl)sulfonyl]piperazin-1-yl}acetamide::SMR000033497::cid_3238707 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42334&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3238707 252623038 ZINC36227792 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79207 CC(=O)N1C(CSC1c1cccc(C)c1)C(O)=O InChI=1S/C13H15NO3S/c1-8-4-3-5-10(6-8)12-14(9(2)15)11(7-18-12)13(16)17/h3-6,11-12H,7H2,1-2H3,(H,16,17) NSPMXKUWUQZFIF-UHFFFAOYSA-N 42335 3-acetyl-2-(3-methylphenyl)-1,3-thiazolidine-4-carboxylic acid::3-acetyl-2-(3-methylphenyl)-4-thiazolidinecarboxylic acid::3-acetyl-2-(m-tolyl)thiazolidine-4-carboxylic acid::3-ethanoyl-2-(3-methylphenyl)-1,3-thiazolidine-4-carboxylic acid::MLS000043420::SMR000020237::cid_3238943 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42335&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3238943 252623039 ZINC00355969 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79208 Brc1ccc(s1)C1=Nn2c(SC1)nnc2-c1cccnc1 InChI=1S/C13H8BrN5S2/c14-11-4-3-10(21-11)9-7-20-13-17-16-12(19(13)18-9)8-2-1-5-15-6-8/h1-6H,7H2 BWZYOZQETLHLMP-UHFFFAOYSA-N 42336 6-(5-bromanylthiophen-2-yl)-3-pyridin-3-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine;hydrobromide::6-(5-bromo-2-thienyl)-3-(3-pyridyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine;hydrobromide::6-(5-bromo-2-thiophenyl)-3-(3-pyridinyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine;hydrobromide::6-(5-bromothien-2-yl)-3-pyridin-3-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine::6-(5-bromothiophen-2-yl)-3-pyridin-3-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine;hydrobromide::MLS000048032::SMR000034015::cid_6603309 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42336&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3239128 252623040 ZINC04101591 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79209 Cc1ccc(C)c(NC(=O)C2CC(O)CN2C(=O)OC(C)(C)C)c1 InChI=1S/C18H26N2O4/c1-11-6-7-12(2)14(8-11)19-16(22)15-9-13(21)10-20(15)17(23)24-18(3,4)5/h6-8,13,15,21H,9-10H2,1-5H3,(H,19,22) FJGOWWXNOCFPSG-UHFFFAOYSA-N 42337 2-[(2,5-dimethylanilino)-oxomethyl]-4-hydroxy-1-pyrrolidinecarboxylic acid tert-butyl ester::2-[(2,5-dimethylphenyl)carbamoyl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester::MLS000090354::SMR000024964::cid_3239315::tert-butyl 2-[(2,5-dimethylphenyl)carbamoyl]-4-hydroxypyrrolidine-1-carboxylate::tert-butyl 2-[(2,5-dimethylphenyl)carbamoyl]-4-oxidanyl-pyrrolidine-1-carboxylate::tert-butyl 2-{[(2,5-dimethylphenyl)amino]carbonyl}-4-hydroxypyrrolidine-1-carboxylate Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42337&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3239315 252623041 ZINC00076647 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79210 Nc1nonc1-c1noc(CCCCCN2C(=O)c3ccccc3C2=O)n1 InChI=1S/C17H16N6O4/c18-14-13(20-27-21-14)15-19-12(26-22-15)8-2-1-5-9-23-16(24)10-6-3-4-7-11(10)17(23)25/h3-4,6-7H,1-2,5,8-9H2,(H2,18,21) YVJQRFCHXFATAO-UHFFFAOYSA-N 42338 2-[5-[3-(4-amino-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazol-5-yl]pentyl]isoindole-1,3-dione::2-[5-[3-(4-aminofurazan-3-yl)-1,2,4-oxadiazol-5-yl]pentyl]isoindoline-1,3-quinone::2-[5-[3-(4-azanyl-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazol-5-yl]pentyl]isoindole-1,3-dione::2-{5-[3-(4-amino-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazol-5-yl]pentyl}-1H-isoindole-1,3(2H)-dione::MLS000043807::SMR000021018::cid_594800 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42338&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 594800 252623042 ZINC03672510 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79211 Cc1c(C)c(=O)oc2c(C)c3oc4CCCCc4c3cc12 InChI=1S/C18H18O3/c1-9-10(2)18(19)21-16-11(3)17-14(8-13(9)16)12-6-4-5-7-15(12)20-17/h8H,4-7H2,1-3H3 YVOWKUKCANOWJK-UHFFFAOYSA-N 42339 3,4,11-trimethyl-6,7,8,9-tetrahydro-2H-[1]benzofuro[3,2-g]chromen-2-one::3,4,11-trimethyl-6,7,8,9-tetrahydro-[1]benzofuro[3,2-g]chromen-2-one::3,4,11-trimethyl-6,7,8,9-tetrahydrobenzofuro[3,2-g][1]benzopyran-2-one::3,4,11-trimethyl-6,7,8,9-tetrahydrobenzofuro[3,2-g]chromen-2-one::MLS000085206::SMR000019746::cid_707674 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42339&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 707674 252623043 ZINC00095150 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79212 CC(=O)N1CCc2cc(ccc12)S(=O)(=O)CCC(=O)N1CCN(CC1)C(=O)c1ccco1 InChI=1S/C22H25N3O6S/c1-16(26)25-8-6-17-15-18(4-5-19(17)25)32(29,30)14-7-21(27)23-9-11-24(12-10-23)22(28)20-3-2-13-31-20/h2-5,13,15H,6-12,14H2,1H3 JDBUMMXRGNSSDY-UHFFFAOYSA-N 42340 1-acetyl-5-({3-[4-(2-furoyl)piperazin-1-yl]-3-oxopropyl}sulfonyl)indoline::3-(1-acetylindolin-5-yl)sulfonyl-1-[4-(2-furoyl)piperazino]propan-1-one::3-[(1-acetyl-2,3-dihydroindol-5-yl)sulfonyl]-1-[4-(furan-2-carbonyl)piperazin-1-yl]propan-1-one::3-[(1-acetyl-2,3-dihydroindol-5-yl)sulfonyl]-1-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-1-propanone::3-[(1-ethanoyl-2,3-dihydroindol-5-yl)sulfonyl]-1-[4-(furan-2-ylcarbonyl)piperazin-1-yl]propan-1-one::MLS000091757::SMR000026304::cid_3239861 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42340&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3239861 252623044 ZINC04101010 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79213 CCC(Sc1nc(C)cc(=O)[nH]1)C(=O)Nc1nc2CCCCc2s1 InChI=1S/C16H20N4O2S2/c1-3-11(23-15-17-9(2)8-13(21)19-15)14(22)20-16-18-10-6-4-5-7-12(10)24-16/h8,11H,3-7H2,1-2H3,(H,17,19,21)(H,18,20,22) JTDWUZNQNOVCKN-UHFFFAOYSA-N 42341 2-[(4-keto-6-methyl-1H-pyrimidin-2-yl)thio]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)butyramide::2-[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]-N-4,5,6,7-tetrahydro-1,3-benzothiazol-2-ylbutanamide::2-[(6-methyl-4-oxidanylidene-1H-pyrimidin-2-yl)sulfanyl]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)butanamide::2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)butanamide::2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)thio]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)butanamide::MLS000085222::SMR000019762::cid_3240030 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42341&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3240030 252623045 ZINC18193247 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79214 CC1CCCCN1CCNS(=O)(=O)c1cc(Br)cc2CCN(C(C)=O)c12 InChI=1S/C18H26BrN3O3S/c1-13-5-3-4-8-21(13)10-7-20-26(24,25)17-12-16(19)11-15-6-9-22(14(2)23)18(15)17/h11-13,20H,3-10H2,1-2H3 YRWVSIJBSXXHIG-UHFFFAOYSA-N 42342 1-acetyl-5-bromo-N-[2-(2-methyl-1-piperidinyl)ethyl]-2,3-dihydroindole-7-sulfonamide::1-acetyl-5-bromo-N-[2-(2-methylpiperidin-1-yl)ethyl]-2,3-dihydroindole-7-sulfonamide::1-acetyl-5-bromo-N-[2-(2-methylpiperidin-1-yl)ethyl]indoline-7-sulfonamide::1-acetyl-5-bromo-N-[2-(2-methylpiperidino)ethyl]indoline-7-sulfonamide::5-bromanyl-1-ethanoyl-N-[2-(2-methylpiperidin-1-yl)ethyl]-2,3-dihydroindole-7-sulfonamide::MLS000086264::SMR000021773::cid_3240048 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42342&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3240048 252623046 ZINC02457164 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79215 CCN(CC)CCCNC(=O)c1cc(on1)-c1cccc(Cl)c1 InChI=1S/C17H22ClN3O2/c1-3-21(4-2)10-6-9-19-17(22)15-12-16(23-20-15)13-7-5-8-14(18)11-13/h5,7-8,11-12H,3-4,6,9-10H2,1-2H3,(H,19,22) RAOGOTKLNJUKFF-UHFFFAOYSA-N 42343 5-(3-chlorophenyl)-N-[3-(diethylamino)propyl]-1,2-oxazole-3-carboxamide::5-(3-chlorophenyl)-N-[3-(diethylamino)propyl]-3-isoxazolecarboxamide::5-(3-chlorophenyl)-N-[3-(diethylamino)propyl]isoxazole-3-carboxamide::MLS000087167::SMR000023390::cid_3240493 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42343&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3240493 252623047 ZINC03908240 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79216 O=S(=O)(NCc1csc(n1)-c1cccnc1)c1ccc2OCCOc2c1 InChI=1S/C17H15N3O4S2/c21-26(22,14-3-4-15-16(8-14)24-7-6-23-15)19-10-13-11-25-17(20-13)12-2-1-5-18-9-12/h1-5,8-9,11,19H,6-7,10H2 DNFASSXKWVVUKK-UHFFFAOYSA-N 42344 MLS000094169::N-[(2-pyridin-3-yl-1,3-thiazol-4-yl)methyl]-2,3-dihydro-1,4-benzodioxine-6-sulfonamide::N-[[2-(3-pyridinyl)-4-thiazolyl]methyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide::N-[[2-(3-pyridyl)thiazol-4-yl]methyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide::SMR000029769::cid_3240548 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42344&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3240548 252623048 ZINC04099491 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79217 COc1cccc(c1)-c1cc(nc(NCc2ccco2)n1)C(F)(F)F InChI=1S/C17H14F3N3O2/c1-24-12-5-2-4-11(8-12)14-9-15(17(18,19)20)23-16(22-14)21-10-13-6-3-7-25-13/h2-9H,10H2,1H3,(H,21,22,23) HFTRAKLGQHUFCD-UHFFFAOYSA-N 42345 2-furfuryl-[4-(3-methoxyphenyl)-6-(trifluoromethyl)pyrimidin-2-yl]amine::MLS000044549::N-(2-furanylmethyl)-4-(3-methoxyphenyl)-6-(trifluoromethyl)-2-pyrimidinamine::N-(2-furylmethyl)-4-(3-methoxyphenyl)-6-(trifluoromethyl)pyrimidin-2-amine::N-(furan-2-ylmethyl)-4-(3-methoxyphenyl)-6-(trifluoromethyl)pyrimidin-2-amine::SMR000022326::cid_2989085 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42345&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2989085 252623049 ZINC02458855 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79218 CN(CC(=O)Nc1ccc(F)c(F)c1)S(=O)(=O)c1cccc2nsnc12 InChI=1S/C15H12F2N4O3S2/c1-21(8-14(22)18-9-5-6-10(16)11(17)7-9)26(23,24)13-4-2-3-12-15(13)20-25-19-12/h2-7H,8H2,1H3,(H,18,22) FXHPOKRVZPKWCI-UHFFFAOYSA-N 42346 2-[2,1,3-benzothiadiazol-4-ylsulfonyl(methyl)amino]-N-(3,4-difluorophenyl)acetamide::2-[2,1,3-benzothiadiazol-4-ylsulfonyl(methyl)amino]-N-[3,4-bis(fluoranyl)phenyl]ethanamide::MLS000045379::N-(3,4-difluorophenyl)-2-[methyl(piazthiol-4-ylsulfonyl)amino]acetamide::N~2~-(2,1,3-benzothiadiazol-4-ylsulfonyl)-N~1~-(3,4-difluorophenyl)-N~2~-methylglycinamide::SMR000027158::cid_3240958 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42346&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3240958 252623050 ZINC04437003 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79219 CC1(C)CC(=O)N(CC(O)=O)c2ccccc2S1 InChI=1S/C13H15NO3S/c1-13(2)7-11(15)14(8-12(16)17)9-5-3-4-6-10(9)18-13/h3-6H,7-8H2,1-2H3,(H,16,17) AKBNVAXNPUUJJF-UHFFFAOYSA-N 42347 (2,2-dimethyl-4-oxo-3,4-dihydro-1,5-benzothiazepin-5(2H)-yl)acetic acid::2-(2,2-dimethyl-4-oxidanylidene-3H-1,5-benzothiazepin-5-yl)ethanoic acid::2-(2,2-dimethyl-4-oxo-3H-1,5-benzothiazepin-5-yl)acetic acid::2-(4-keto-2,2-dimethyl-3H-1,5-benzothiazepin-5-yl)acetic acid::MLS000045978::SMR000031587::cid_2728645 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42347&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2728645 252623051 ZINC04173818 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79220 O=C(CCS(=O)(=O)c1cccc2nonc12)N1CCCc2ccccc12 InChI=1S/C18H17N3O4S/c22-17(21-11-4-6-13-5-1-2-8-15(13)21)10-12-26(23,24)16-9-3-7-14-18(16)20-25-19-14/h1-3,5,7-9H,4,6,10-12H2 HNQOFOMKBWSKLP-UHFFFAOYSA-N 42348 1-[3-(2,1,3-benzoxadiazol-4-ylsulfonyl)propanoyl]-1,2,3,4-tetrahydroquinoline::3-(2,1,3-benzoxadiazol-4-ylsulfonyl)-1-(3,4-dihydro-2H-quinolin-1-yl)-1-propanone::3-(2,1,3-benzoxadiazol-4-ylsulfonyl)-1-(3,4-dihydro-2H-quinolin-1-yl)propan-1-one::3-benzofurazan-4-ylsulfonyl-1-(3,4-dihydro-2H-quinolin-1-yl)propan-1-one::MLS000044347::SMR000022124::cid_3241325 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42348&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3241325 252623052 ZINC03665123 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79221 ONC(=N)c1nc(nc(n1)N1CCCCC1)N1CCCCC1 InChI=1S/C14H23N7O/c15-11(19-22)12-16-13(20-7-3-1-4-8-20)18-14(17-12)21-9-5-2-6-10-21/h22H,1-10H2,(H2,15,19) DJTPXVULNONQRD-UHFFFAOYSA-N 42349 (E)-[4,6-bis(1-piperidinyl)-1H-1,3,5-triazin-2-ylidene]-nitrosomethanamine::(E)-[4,6-di(piperidin-1-yl)-1H-1,3,5-triazin-2-ylidene]-nitroso-methanamine::(E)-[4,6-di(piperidin-1-yl)-1H-1,3,5-triazin-2-ylidene]-nitrosomethanamine::MLS000044066::N'-hydroxy-4,6-dipiperidin-1-yl-1,3,5-triazine-2-carboximidamide::SMR000021477::[(E)-(4,6-dipiperidino-1H-s-triazin-2-ylidene)-nitroso-methyl]amine::cid_6245349 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42349&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 5771411 252623053 ZINC61862935 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79222 CC(N=O)c1ccc2c(c1)n(C)c1ccccc21 InChI=1S/C15H14N2O/c1-10(16-18)11-7-8-13-12-5-3-4-6-14(12)17(2)15(13)9-11/h3-10H,1-2H3 UBTRXBCRDWVRER-UHFFFAOYSA-N 42350 (1E)-1-(9-methyl-9H-carbazol-2-yl)ethanone oxime::1-(9-methyl-2-carbazolyl)ethanone oxime::1-(9-methylcarbazol-2-yl)ethanone oxime::MLS000085180::N-[1-(9-methylcarbazol-2-yl)ethylidene]hydroxylamine::SMR000019720::cid_752835 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42350&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 91896532 252623054 ZINC12377847 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79223 Cc1cccn2c1nc(NCCO)c(C=Nc1ccc(Cl)cc1)c2=O InChI=1S/C18H17ClN4O2/c1-12-3-2-9-23-17(12)22-16(20-8-10-24)15(18(23)25)11-21-14-6-4-13(19)5-7-14/h2-7,9,11,20,24H,8,10H2,1H3 GBOOMRLVNXMOQM-UHFFFAOYSA-N 42351 (3E)-3-[(4-chloroanilino)methylene]-2-(2-hydroxyethylimino)-9-methyl-pyrido[1,2-a]pyrimidin-4-one::(3E)-3-[(4-chloroanilino)methylidene]-2-(2-hydroxyethylimino)-9-methyl-4-pyrido[1,2-a]pyrimidinone::(3E)-3-[(4-chloroanilino)methylidene]-2-(2-hydroxyethylimino)-9-methylpyrido[1,2-a]pyrimidin-4-one::(3E)-3-[[(4-chlorophenyl)amino]methylidene]-2-(2-hydroxyethylimino)-9-methyl-pyrido[1,2-a]pyrimidin-4-one::MLS000087761::SMR000015746::cid_5310466 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 5310466 252623055 ZINC18140246 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79224 Cc1ccccc1CS(=O)(=O)Cc1ccc(o1)C(=O)NCc1ccco1 InChI=1S/C19H19NO5S/c1-14-5-2-3-6-15(14)12-26(22,23)13-17-8-9-18(25-17)19(21)20-11-16-7-4-10-24-16/h2-10H,11-13H2,1H3,(H,20,21) ALVHKHRIFNKTMS-UHFFFAOYSA-N 42352 MLS000046419::N-(2-furanylmethyl)-5-[(2-methylphenyl)methylsulfonylmethyl]-2-furancarboxamide::N-(2-furfuryl)-5-[(2-methylbenzyl)sulfonylmethyl]-2-furamide::N-(2-furylmethyl)-5-{[(2-methylbenzyl)sulfonyl]methyl}-2-furamide::N-(furan-2-ylmethyl)-5-[(2-methylphenyl)methylsulfonylmethyl]furan-2-carboxamide::SMR000032430::cid_3242263 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42352&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3242263 252623056 ZINC03006086 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79225 CC(C)n1c2c([nH]c1=S)n(C)c(=O)[nH]c2=O InChI=1S/C9H12N4O2S/c1-4(2)13-5-6(10-9(13)16)12(3)8(15)11-7(5)14/h4H,1-3H3,(H,10,16)(H,11,14,15) BIPXEDYGKRHJHF-UHFFFAOYSA-N 42353 3-methyl-7-propan-2-yl-8-sulfanylidene-9H-purine-2,6-dione::7-isopropyl-3-methyl-8-thioxo-3,7,8,9-tetrahydro-1H-purine-2,6-dione::7-isopropyl-3-methyl-8-thioxo-9H-purine-2,6-quinone::MLS000087713::SMR000082834::cid_840403 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42353&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 840403 252623057 ZINC00381248 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79226 CN(c1cc(C)ccc1C)S(=O)(=O)c1cccc2nsnc12 InChI=1S/C15H15N3O2S2/c1-10-7-8-11(2)13(9-10)18(3)22(19,20)14-6-4-5-12-15(14)17-21-16-12/h4-9H,1-3H3 PLEKKJCSEZQOQM-UHFFFAOYSA-N 42354 MLS000044440::N-(2,5-dimethylphenyl)-N-methyl-2,1,3-benzothiadiazole-4-sulfonamide::N-(2,5-dimethylphenyl)-N-methyl-piazthiole-4-sulfonamide::SMR000022217::cid_3242355 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42354&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3242355 252623058 ZINC00212998 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79227 O=C(CCNS(=O)(=O)c1cccc2nsnc12)NC1CCN(Cc2ccccc2)CC1 InChI=1S/C21H25N5O3S2/c27-20(23-17-10-13-26(14-11-17)15-16-5-2-1-3-6-16)9-12-22-31(28,29)19-8-4-7-18-21(19)25-30-24-18/h1-8,17,22H,9-15H2,(H,23,27) IJLHTKMSXQEBQG-UHFFFAOYSA-N 42355 3-(2,1,3-benzothiadiazol-4-ylsulfonylamino)-N-(1-benzylpiperidin-4-yl)propanamide::3-(2,1,3-benzothiadiazol-4-ylsulfonylamino)-N-[1-(phenylmethyl)-4-piperidinyl]propanamide::3-(2,1,3-benzothiadiazol-4-ylsulfonylamino)-N-[1-(phenylmethyl)piperidin-4-yl]propanamide::MLS000044398::N-(1-benzyl-4-piperidyl)-3-(piazthiol-4-ylsulfonylamino)propionamide::N~3~-(2,1,3-benzothiadiazol-4-ylsulfonyl)-N~1~-(1-benzylpiperidin-4-yl)-beta-alaninamide::SMR000022175::cid_3242583 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42355&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3242583 252623059 ZINC04077347 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79228 FC(F)(F)c1ccc(N2CCOCC2)c(Nc2nc3ccccc3n3cnnc23)c1 InChI=1S/C20H17F3N6O/c21-20(22,23)13-5-6-16(28-7-9-30-10-8-28)15(11-13)26-18-19-27-24-12-29(19)17-4-2-1-3-14(17)25-18/h1-6,11-12H,7-10H2,(H,25,26) XJFJINZMGHGLPK-UHFFFAOYSA-N 35402 MLS000093276::N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine::N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine::N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-a]quinoxalin-4-amine::SMR000028898::[2-morpholino-5-(trifluoromethyl)phenyl]-([1,2,4]triazolo[4,3-a]quinoxalin-4-yl)amine::cid_3242631 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35402&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3242631 252617670 ZINC04056497 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79229 Cc1ccc(cc1)S(=O)(=O)Nc1cc(ccc1N1CCCCC1)C(O)=O InChI=1S/C19H22N2O4S/c1-14-5-8-16(9-6-14)26(24,25)20-17-13-15(19(22)23)7-10-18(17)21-11-3-2-4-12-21/h5-10,13,20H,2-4,11-12H2,1H3,(H,22,23) OFMWCZQKDYLGRA-UHFFFAOYSA-N 42356 3-[(4-methylphenyl)sulfonylamino]-4-(1-piperidinyl)benzoic acid::3-[(4-methylphenyl)sulfonylamino]-4-piperidin-1-yl-benzoic acid::3-[(4-methylphenyl)sulfonylamino]-4-piperidin-1-ylbenzoic acid::3-{[(4-methylphenyl)sulfonyl]amino}-4-piperidin-1-ylbenzoic acid::4-piperidino-3-(tosylamino)benzoic acid::MLS000095997::SMR000031545::cid_3242990 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42356&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3242990 252623060 ZINC03028958 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79230 Clc1ccc(NC(=O)NCCCn2ccnc2)cc1 InChI=1S/C13H15ClN4O/c14-11-2-4-12(5-3-11)17-13(19)16-6-1-8-18-9-7-15-10-18/h2-5,7,9-10H,1,6,8H2,(H2,16,17,19) SNQYQRBZLIAPFA-UHFFFAOYSA-N 42357 1-(4-chlorophenyl)-3-(3-imidazol-1-ylpropyl)urea::1-(4-chlorophenyl)-3-[3-(1-imidazolyl)propyl]urea::MLS000087712::N-(4-chlorophenyl)-N'-[3-(1H-imidazol-1-yl)propyl]urea::SMR000023933::cid_2804810 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42357&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2804810 252623061 ZINC02478420 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79231 CC(C)C(NC(=O)C1CCC(C)CC1)C(=O)NCCCN1CCOCC1 InChI=1S/C20H37N3O3/c1-15(2)18(22-19(24)17-7-5-16(3)6-8-17)20(25)21-9-4-10-23-11-13-26-14-12-23/h15-18H,4-14H2,1-3H3,(H,21,25)(H,22,24) DUKYVKPIHXPZSU-UHFFFAOYSA-N 42358 4-methyl-N-[2-methyl-1-(3-morpholinopropylcarbamoyl)propyl]cyclohexanecarboxamide::4-methyl-N-[3-methyl-1-(3-morpholin-4-ylpropylamino)-1-oxidanylidene-butan-2-yl]cyclohexane-1-carboxamide::4-methyl-N-[3-methyl-1-(3-morpholin-4-ylpropylamino)-1-oxobutan-2-yl]cyclohexane-1-carboxamide::4-methyl-N-[3-methyl-1-[3-(4-morpholinyl)propylamino]-1-oxobutan-2-yl]-1-cyclohexanecarboxamide::MLS000095025::SMR000030576::cid_3243058 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3243058 252623062 ZINC19900225 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79232 COc1cccc(NC(=O)C2C3OC4(C=C3)C2C(=O)N(C(C)C)C4C(=O)NC2CCCCC2C)c1 InChI=1S/C27H35N3O5/c1-15(2)30-23(25(32)29-19-11-6-5-8-16(19)3)27-13-12-20(35-27)21(22(27)26(30)33)24(31)28-17-9-7-10-18(14-17)34-4/h7,9-10,12-16,19-23H,5-6,8,11H2,1-4H3,(H,28,31)(H,29,32) RZFCFNKCEHOXSQ-UHFFFAOYSA-N 42359 2-isopropyl-N~7~-(3-methoxyphenyl)-N~3~-(2-methylcyclohexyl)-1-oxo-1,2,3,6,7,7a-hexahydro-3a,6-epoxyisoindole-3,7-dicarboxamide::MLS000086274::SMR000021783::cid_3243229 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42359&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3243229 242053019 ZINC04035801 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79233 Cc1cccn2c1nc1n(C)c(cc1c2=O)C(=O)NCCCn1ccnc1 InChI=1S/C19H20N6O2/c1-13-5-3-9-25-16(13)22-17-14(19(25)27)11-15(23(17)2)18(26)21-6-4-8-24-10-7-20-12-24/h3,5,7,9-12H,4,6,8H2,1-2H3,(H,21,26) RBIMOCNCXCOONR-UHFFFAOYSA-N 42360 MLS000094491::N-[3-(1H-imidazol-1-yl)propyl]-1,9-dimethyl-4-oxo-1,4-dihydropyrido[1,2-a]pyrrolo[2,3-d]pyrimidine-2-carboxamide::SMR000030051::cid_3243418 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42360&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3243418 242053020 ZINC02917311 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79234 CCOC(=O)c1ccc(NC(=O)CSc2nc(O)c(CC)c(=O)[nH]2)cc1 InChI=1S/C17H19N3O5S/c1-3-12-14(22)19-17(20-15(12)23)26-9-13(21)18-11-7-5-10(6-8-11)16(24)25-4-2/h5-8H,3-4,9H2,1-2H3,(H,18,21)(H2,19,20,22,23) LISVZTXIASWGBH-UHFFFAOYSA-N 42361 4-[[2-[(5-ethyl-4,6-diketo-1H-pyrimidin-2-yl)thio]acetyl]amino]benzoic acid ethyl ester::4-[[2-[(5-ethyl-4,6-dioxo-1H-pyrimidin-2-yl)thio]-1-oxoethyl]amino]benzoic acid ethyl ester::MLS000085233::SMR000019773::cid_3243465::ethyl 4-({[(5-ethyl-4,6-dioxo-1,4,5,6-tetrahydropyrimidin-2-yl)thio]acetyl}amino)benzoate::ethyl 4-[2-[[5-ethyl-4,6-bis(oxidanylidene)-1H-pyrimidin-2-yl]sulfanyl]ethanoylamino]benzoate::ethyl 4-[[2-[(5-ethyl-4,6-dioxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]amino]benzoate Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42361&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16469660 252623063 ZINC09907701 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79235 CCCCN(C)C(=O)CCCCn1c(=O)[nH]c2cc(OCC)c(OCC)cc2c1=O InChI=1S/C22H33N3O5/c1-5-8-12-24(4)20(26)11-9-10-13-25-21(27)16-14-18(29-6-2)19(30-7-3)15-17(16)23-22(25)28/h14-15H,5-13H2,1-4H3,(H,23,28) YRSQJPGULPLBJK-UHFFFAOYSA-N 42362 MLS000094696::N-butyl-5-(6,7-diethoxy-2,4-diketo-1H-quinazolin-3-yl)-N-methyl-valeramide::N-butyl-5-(6,7-diethoxy-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-methylpentanamide::N-butyl-5-(6,7-diethoxy-2,4-dioxo-1H-quinazolin-3-yl)-N-methylpentanamide::N-butyl-5-[6,7-diethoxy-2,4-bis(oxidanylidene)-1H-quinazolin-3-yl]-N-methyl-pentanamide::SMR000030249::cid_3243769 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42362&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3243769 252623064 ZINC04003775 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79236 CCOC(=O)N1CCN(CC1)C(=O)c1ccc2c(c1)[nH]c(=S)n(Cc1ccccc1)c2=O InChI=1S/C23H24N4O4S/c1-2-31-23(30)26-12-10-25(11-13-26)20(28)17-8-9-18-19(14-17)24-22(32)27(21(18)29)15-16-6-4-3-5-7-16/h3-9,14H,2,10-13,15H2,1H3,(H,24,32) HYBXAFNJZDBIEH-UHFFFAOYSA-N 42363 4-(3-benzyl-4-keto-2-thioxo-1H-quinazoline-7-carbonyl)piperazine-1-carboxylic acid ethyl ester::4-[oxo-[4-oxo-3-(phenylmethyl)-2-sulfanylidene-1H-quinazolin-7-yl]methyl]-1-piperazinecarboxylic acid ethyl ester::MLS000044077::SMR000021488::cid_3243888::ethyl 4-(3-benzyl-4-oxo-2-sulfanylidene-1H-quinazoline-7-carbonyl)piperazine-1-carboxylate::ethyl 4-[(3-benzyl-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazolin-7-yl)carbonyl]piperazine-1-carboxylate::ethyl 4-[[4-oxidanylidene-3-(phenylmethyl)-2-sulfanylidene-1H-quinazolin-7-yl]carbonyl]piperazine-1-carboxylate Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42363&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3243888 252623065 ZINC04003767 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79237 COc1cccc2cc(NC(=O)C3CCCCC3)c(=O)oc12 InChI=1S/C17H19NO4/c1-21-14-9-5-8-12-10-13(17(20)22-15(12)14)18-16(19)11-6-3-2-4-7-11/h5,8-11H,2-4,6-7H2,1H3,(H,18,19) WVUQUXZEAUCRBK-UHFFFAOYSA-N 42364 MLS000087724::N-(2-keto-8-methoxy-chromen-3-yl)cyclohexanecarboxamide::N-(8-methoxy-2-oxidanylidene-chromen-3-yl)cyclohexanecarboxamide::N-(8-methoxy-2-oxo-1-benzopyran-3-yl)cyclohexanecarboxamide::N-(8-methoxy-2-oxo-2H-chromen-3-yl)cyclohexanecarboxamide::N-(8-methoxy-2-oxochromen-3-yl)cyclohexanecarboxamide::SMR000023945::cid_3244097 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42364&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3244097 252623066 ZINC00381537 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79238 CCCCN(CC)S(=O)(=O)c1ccc(cc1)C(=O)Nc1nnc(CSC)o1 InChI=1S/C17H24N4O4S2/c1-4-6-11-21(5-2)27(23,24)14-9-7-13(8-10-14)16(22)18-17-20-19-15(25-17)12-26-3/h7-10H,4-6,11-12H2,1-3H3,(H,18,20,22) ZDFGBFFUUMQLKE-UHFFFAOYSA-N 42365 4-[butyl(ethyl)sulfamoyl]-N-[5-(methylsulfanylmethyl)-1,3,4-oxadiazol-2-yl]benzamide::4-[butyl(ethyl)sulfamoyl]-N-[5-[(methylthio)methyl]-1,3,4-oxadiazol-2-yl]benzamide::4-{[butyl(ethyl)amino]sulfonyl}-N-{5-[(methylthio)methyl]-1,3,4-oxadiazol-2-yl}benzamide::MLS000086360::SMR000021862::cid_2155641 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42365&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2155641 252623067 ZINC02720219 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79239 O=C(NCCCN1CCCC1=O)c1ccc2c(c1)[nH]c(=S)n(Cc1ccco1)c2=O InChI=1S/C21H22N4O4S/c26-18-5-1-9-24(18)10-3-8-22-19(27)14-6-7-16-17(12-14)23-21(30)25(20(16)28)13-15-4-2-11-29-15/h2,4,6-7,11-12H,1,3,5,8-10,13H2,(H,22,27)(H,23,30) DVGXHXCVIQKHOH-UHFFFAOYSA-N 42366 3-(2-furanylmethyl)-4-oxo-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-2-sulfanylidene-1H-quinazoline-7-carboxamide::3-(2-furfuryl)-4-keto-N-[3-(2-ketopyrrolidino)propyl]-2-thioxo-1H-quinazoline-7-carboxamide::3-(2-furylmethyl)-4-oxo-N-[3-(2-oxopyrrolidin-1-yl)propyl]-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide::3-(furan-2-ylmethyl)-4-oxidanylidene-N-[3-(2-oxidanylidenepyrrolidin-1-yl)propyl]-2-sulfanylidene-1H-quinazoline-7-carboxamide::3-(furan-2-ylmethyl)-4-oxo-N-[3-(2-oxopyrrolidin-1-yl)propyl]-2-sulfanylidene-1H-quinazoline-7-carboxamide::MLS000044087::SMR000021498::cid_3244211 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42366&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3244211 252623068 ZINC03631875 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79240 Cn1c(nc2ccccc12)C(C#N)C(=O)c1ccc(cc1)S(=O)(=O)N1CCCCC1 InChI=1S/C22H22N4O3S/c1-25-20-8-4-3-7-19(20)24-22(25)18(15-23)21(27)16-9-11-17(12-10-16)30(28,29)26-13-5-2-6-14-26/h3-4,7-12,18H,2,5-6,13-14H2,1H3 VGTHFJOPFAKNJC-UHFFFAOYSA-N 42367 (2E)-2-(1-methyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-3-oxo-3-[4-(piperidin-1-ylsulfonyl)phenyl]propanenitrile::(2E)-2-(3-methyl-1H-benzimidazol-2-ylidene)-3-oxidanylidene-3-(4-piperidin-1-ylsulfonylphenyl)propanenitrile::(2E)-2-(3-methyl-1H-benzimidazol-2-ylidene)-3-oxo-3-(4-piperidin-1-ylsulfonylphenyl)propanenitrile::(2E)-2-(3-methyl-1H-benzimidazol-2-ylidene)-3-oxo-3-[4-(1-piperidinylsulfonyl)phenyl]propanenitrile::(2E)-3-keto-2-(3-methyl-1H-benzimidazol-2-ylidene)-3-(4-piperidinosulfonylphenyl)propionitrile::MLS000087762::SMR000023982::cid_5771470 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42367&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 24156856 252623069 ZINC13123503 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79241 Cc1cc2ccccc2c(=O)n1CC(=O)NCC(=O)N1CCN(CC1)c1ccccc1 InChI=1S/C24H26N4O3/c1-18-15-19-7-5-6-10-21(19)24(31)28(18)17-22(29)25-16-23(30)27-13-11-26(12-14-27)20-8-3-2-4-9-20/h2-10,15H,11-14,16-17H2,1H3,(H,25,29) KTPSKHJLDGYFCP-UHFFFAOYSA-N 42368 2-(1-keto-3-methyl-2-isoquinolyl)-N-[2-keto-2-(4-phenylpiperazino)ethyl]acetamide::2-(3-methyl-1-oxidanylidene-isoquinolin-2-yl)-N-[2-oxidanylidene-2-(4-phenylpiperazin-1-yl)ethyl]ethanamide::2-(3-methyl-1-oxo-2-isoquinolinyl)-N-[2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]acetamide::2-(3-methyl-1-oxoisoquinolin-2-yl)-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]acetamide::MLS000095015::SMR000030566::cid_3244436 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42368&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3244436 252623070 ZINC03620306 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79242 CCOCCCn1c2nc3c(C)cccn3c(=O)c2cc(C(=O)NCCN2CCOCC2)c1=N InChI=1S/C24H32N6O4/c1-3-33-13-5-9-29-20(25)18(23(31)26-7-10-28-11-14-34-15-12-28)16-19-22(29)27-21-17(2)6-4-8-30(21)24(19)32/h4,6,8,16,25H,3,5,7,9-15H2,1-2H3,(H,26,31) FAGACOLOZVLICA-UHFFFAOYSA-N 42369 1-(3-ethoxypropyl)-2-imino-10-methyl-N-(2-morpholin-4-ylethyl)-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide::1-(3-ethoxypropyl)-2-imino-10-methyl-N-(2-morpholin-4-ylethyl)-5-oxodipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::1-(3-ethoxypropyl)-2-imino-10-methyl-N-[2-(4-morpholinyl)ethyl]-5-oxo-3-dipyrido[3,4-c:1',2'-f]pyrimidinecarboxamide::1-(3-ethoxypropyl)-2-imino-5-keto-10-methyl-N-(2-morpholinoethyl)dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::2-azanylidene-1-(3-ethoxypropyl)-10-methyl-N-(2-morpholin-4-ylethyl)-5-oxidanylidene-dipyrido[3,4-c:1',2'-f]pyrimidine-3-carboxamide::MLS000085141::SMR000019681::cid_3244697 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42369&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3244697 252623071 ZINC24117351 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79243 CCOc1ccc(c2cccnc12)S(=O)(=O)NCC1CCCO1 InChI=1S/C16H20N2O4S/c1-2-21-14-7-8-15(13-6-3-9-17-16(13)14)23(19,20)18-11-12-5-4-10-22-12/h3,6-9,12,18H,2,4-5,10-11H2,1H3 HCPHVOHKWUYTAO-UHFFFAOYSA-N 42370 8-ethoxy-N-(2-oxolanylmethyl)-5-quinolinesulfonamide::8-ethoxy-N-(oxolan-2-ylmethyl)quinoline-5-sulfonamide::8-ethoxy-N-(tetrahydrofuran-2-ylmethyl)quinoline-5-sulfonamide::8-ethoxy-N-(tetrahydrofurfuryl)quinoline-5-sulfonamide::MLS000086052::SMR000021580::cid_3244767 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42370&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3244767 252623072 ZINC00211232 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79244 CCOc1ccccc1C1C(C(=O)Nc2ccccc2OC)C(C)=Nc2nnnn12 InChI=1S/C21H22N6O3/c1-4-30-16-11-7-5-9-14(16)19-18(13(2)22-21-24-25-26-27(19)21)20(28)23-15-10-6-8-12-17(15)29-3/h5-12,18-19H,4H2,1-3H3,(H,23,28) WLHXMSIXHBKGDB-UHFFFAOYSA-N 42371 7-(2-ethoxyphenyl)-N-(2-methoxyphenyl)-5-methyl-1,7-dihydro-[1,2,3,4]tetrazolo[1,5-a]pyrimidine-6-carboxamide::7-(2-ethoxyphenyl)-N-(2-methoxyphenyl)-5-methyl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide::7-(2-ethoxyphenyl)-N-(2-methoxyphenyl)-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide::MLS000090530::N-(2-methoxyphenyl)-5-methyl-7-o-phenetyl-1,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide::SMR000025134::cid_5711795 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42371&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 91896533 252623073 ZINC13125217 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79245 OC1(N(C(=O)Nc2ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)NC1CC1 InChI=1S/C18H15Cl2N3O3/c19-13-8-7-11(9-14(13)20)23-17(25)22-15-4-2-1-3-12(15)18(23,26)16(24)21-10-5-6-10/h1-4,7-10,26H,5-6H2,(H,21,24)(H,22,25) JKXNEWQEOGIYSJ-UHFFFAOYSA-N 42372 MLS000044409::N-cyclopropyl-3-(3,4-dichlorophenyl)-4-hydroxy-2-keto-1H-quinazoline-4-carboxamide::N-cyclopropyl-3-(3,4-dichlorophenyl)-4-hydroxy-2-oxo-1,2,3,4-tetrahydroquinazoline-4-carboxamide::N-cyclopropyl-3-(3,4-dichlorophenyl)-4-hydroxy-2-oxo-1H-quinazoline-4-carboxamide::N-cyclopropyl-3-(3,4-dichlorophenyl)-4-oxidanyl-2-oxidanylidene-1H-quinazoline-4-carboxamide::SMR000022186::cid_3245305 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42372&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3245305 252623074 ZINC03665934 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79246 CCCCN(CC)CCCNC(=O)c1cc2cc3ccc(OC)cc3nc2o1 InChI=1S/C22H29N3O3/c1-4-6-11-25(5-2)12-7-10-23-21(26)20-14-17-13-16-8-9-18(27-3)15-19(16)24-22(17)28-20/h8-9,13-15H,4-7,10-12H2,1-3H3,(H,23,26) ANBKKASGIKXMKZ-UHFFFAOYSA-N 42373 MLS000091923::N-[3-[butyl(ethyl)amino]propyl]-7-methoxy-2-furo[2,3-b]quinolinecarboxamide::N-[3-[butyl(ethyl)amino]propyl]-7-methoxy-furo[2,3-b]quinoline-2-carboxamide::N-[3-[butyl(ethyl)amino]propyl]-7-methoxyfuro[2,3-b]quinoline-2-carboxamide::N-{3-[butyl(ethyl)amino]propyl}-7-methoxyfuro[2,3-b]quinoline-2-carboxamide::SMR000026447::cid_3245431 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42373&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3245431 252623075 ZINC03959239 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79247 CCOC(=O)CN1C(=O)CSc2ccccc12 InChI=1S/C12H13NO3S/c1-2-16-12(15)7-13-9-5-3-4-6-10(9)17-8-11(13)14/h3-6H,2,7-8H2,1H3 SVCWFHUVHSQFAD-UHFFFAOYSA-N 42374 2-(3-keto-1,4-benzothiazin-4-yl)acetic acid ethyl ester::2-(3-oxo-1,4-benzothiazin-4-yl)acetic acid ethyl ester::MLS000095979::SMR000031527::cid_3245459::ethyl (3-oxo-2,3-dihydro-4H-1,4-benzothiazin-4-yl)acetate::ethyl 2-(3-oxidanylidene-1,4-benzothiazin-4-yl)ethanoate::ethyl 2-(3-oxo-1,4-benzothiazin-4-yl)acetate Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42374&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3245459 252623076 ZINC00259613 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79248 Oc1cc(=O)[nH]c(=O)n1-c1ccc2OCOc2c1 InChI=1S/C11H8N2O5/c14-9-4-10(15)13(11(16)12-9)6-1-2-7-8(3-6)18-5-17-7/h1-4,15H,5H2,(H,12,14,16) ZINZWUGEQBZXBA-UHFFFAOYSA-N 42375 1-(1,3-benzodioxol-5-yl)-1,3-diazinane-2,4,6-trione::1-(1,3-benzodioxol-5-yl)-2,4,6(1H,3H,5H)-pyrimidinetrione::1-(1,3-benzodioxol-5-yl)barbituric acid::MLS000061984::SMR000070845::cid_2275254 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42375&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1526963 252623077 ZINC06059312 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79249 Cc1c(Cl)cccc1N(CC(O)=O)S(C)(=O)=O InChI=1S/C10H12ClNO4S/c1-7-8(11)4-3-5-9(7)12(6-10(13)14)17(2,15)16/h3-5H,6H2,1-2H3,(H,13,14) GVGVHTCXGXVEFM-UHFFFAOYSA-N 42376 2-(3-chloro-2-methyl-N-methylsulfonylanilino)acetic acid::2-(3-chloro-N-mesyl-2-methyl-anilino)acetic acid::2-[(3-chloranyl-2-methyl-phenyl)-methylsulfonyl-amino]ethanoic acid::MLS000061924::N-(3-chloro-2-methylphenyl)-N-(methylsulfonyl)glycine::SMR000070785::cid_846773 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42376&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 846773 252623078 ZINC00379845 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79250 Cc1ccc(C)c(OCCCC(=O)NCC=C)c1 InChI=1S/C15H21NO2/c1-4-9-16-15(17)6-5-10-18-14-11-12(2)7-8-13(14)3/h4,7-8,11H,1,5-6,9-10H2,2-3H3,(H,16,17) STYCGUFAPQLLLC-UHFFFAOYSA-N 42377 4-(2,5-dimethylphenoxy)-N-prop-2-enyl-butanamide::4-(2,5-dimethylphenoxy)-N-prop-2-enylbutanamide::MLS000088694::N-allyl-4-(2,5-dimethylphenoxy)butanamide::N-allyl-4-(2,5-dimethylphenoxy)butyramide::SMR000072710::cid_1570484 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42377&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1570484 252623079 ZINC01779954 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79251 COCc1cc(C)nc(NC2CCCCC2)c1C#N InChI=1S/C15H21N3O/c1-11-8-12(10-19-2)14(9-16)15(17-11)18-13-6-4-3-5-7-13/h8,13H,3-7,10H2,1-2H3,(H,17,18) QJWCTDCYFSLQAW-UHFFFAOYSA-N 42378 2-(cyclohexylamino)-4-(methoxymethyl)-6-methyl-3-pyridinecarbonitrile::2-(cyclohexylamino)-4-(methoxymethyl)-6-methyl-nicotinonitrile::2-(cyclohexylamino)-4-(methoxymethyl)-6-methyl-pyridine-3-carbonitrile::2-(cyclohexylamino)-4-(methoxymethyl)-6-methylnicotinonitrile::2-(cyclohexylamino)-4-(methoxymethyl)-6-methylpyridine-3-carbonitrile::MLS000061968::SMR000070829::cid_886683 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42378&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 886683 252623080 ZINC19794951 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79252 Cc1cc(NC(=O)CSc2nc3ccccc3[nH]2)no1 InChI=1S/C13H12N4O2S/c1-8-6-11(17-19-8)16-12(18)7-20-13-14-9-4-2-3-5-10(9)15-13/h2-6H,7H2,1H3,(H,14,15)(H,16,17,18) ALVRSIIVBMUCBC-UHFFFAOYSA-N 42379 2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-methyl-1,2-oxazol-3-yl)acetamide::2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-methyl-1,2-oxazol-3-yl)ethanamide::2-(1H-benzimidazol-2-ylthio)-N-(5-methyl-3-isoxazolyl)acetamide::2-(1H-benzimidazol-2-ylthio)-N-(5-methylisoxazol-3-yl)acetamide::MLS000061908::SMR000070767::cid_684683 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42379&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 684683 252623081 ZINC00051367 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79253 Cc1cc2c(C)cc(=O)oc2c2CCCNc12 InChI=1S/C14H15NO2/c1-8-7-12(16)17-14-10-4-3-5-15-13(10)9(2)6-11(8)14/h6-7,15H,3-5H2,1-2H3 HNBLXGUKCHVXSO-UHFFFAOYSA-N 42380 4,6-dimethyl-7,8,9,10-tetrahydro-2H-pyrano[2,3-f]quinolin-2-one::4,6-dimethyl-7,8,9,10-tetrahydropyrano[2,3-f]quinolin-2-one::MLS000059234::SMR000069698::cid_760021 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42380&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 760021 252623082 ZINC37858711 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79254 COc1ccc(cc1)-c1c2CCCc2nc2sc(C(=O)Nc3cc(C)on3)c(N)c12 InChI=1S/C22H20N4O3S/c1-11-10-16(26-29-11)25-21(27)20-19(23)18-17(12-6-8-13(28-2)9-7-12)14-4-3-5-15(14)24-22(18)30-20/h6-10H,3-5,23H2,1-2H3,(H,25,26,27) BEDLVVKLVDDSHO-UHFFFAOYSA-N 38438 3-amino-4-(4-methoxyphenyl)-N-(5-methyl-3-isoxazolyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide::MLS000050717::SMR000078193::cid_1201903 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=38438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=38438&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1201903 242052945 ZINC00968939 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79255 S=c1[nH]nc(Cc2ccccc2)n1Cc1ccco1 InChI=1S/C14H13N3OS/c19-14-16-15-13(9-11-5-2-1-3-6-11)17(14)10-12-7-4-8-18-12/h1-8H,9-10H2,(H,16,19) KXLVXORPOHNALY-UHFFFAOYSA-N 42381 3-benzyl-4-(2-furfuryl)-1H-1,2,4-triazole-5-thione::3-benzyl-4-(furan-2-ylmethyl)-1H-1,2,4-triazole-5-thione::4-(2-furanylmethyl)-3-(phenylmethyl)-1H-1,2,4-triazole-5-thione::4-(furan-2-ylmethyl)-3-(phenylmethyl)-1H-1,2,4-triazole-5-thione::5-benzyl-4-(2-furylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione::MLS000088730::SMR000072751::cid_891086 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42381&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 891086 252623083 ZINC06492416 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79256 Clc1cccc(CN2CC3CC(C2)c2cccc(=O)n2C3)c1Cl InChI=1S/C18H18Cl2N2O/c19-15-4-1-3-13(18(15)20)10-21-8-12-7-14(11-21)16-5-2-6-17(23)22(16)9-12/h1-6,12,14H,7-11H2 QEEIYTFWZSCOSS-UHFFFAOYSA-N 42382 11-(2,3-dichlorobenzyl)-7,11-diazatricyclo[7.3.1.0~2,7~]trideca-2,4-dien-6-one::MLS000061638::SMR000069969::cid_2857421 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42382&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2857421 242053021 ZINC19732686 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79257 COC(=O)c1sc(NC(=O)c2csc3CCCCc23)nc1C InChI=1S/C15H16N2O3S2/c1-8-12(14(19)20-2)22-15(16-8)17-13(18)10-7-21-11-6-4-3-5-9(10)11/h7H,3-6H2,1-2H3,(H,16,17,18) OILVDCAEQZNVRB-UHFFFAOYSA-N 42383 4-methyl-2-(4,5,6,7-tetrahydrobenzothiophene-3-carbonylamino)thiazole-5-carboxylic acid methyl ester::4-methyl-2-[[oxo(4,5,6,7-tetrahydro-1-benzothiophen-3-yl)methyl]amino]-5-thiazolecarboxylic acid methyl ester::MLS000065667::SMR000080317::cid_1245230::methyl 4-methyl-2-(4,5,6,7-tetrahydro-1-benzothiophen-3-ylcarbonylamino)-1,3-thiazole-5-carboxylate::methyl 4-methyl-2-(4,5,6,7-tetrahydro-1-benzothiophene-3-carbonylamino)-1,3-thiazole-5-carboxylate::methyl 4-methyl-2-[(4,5,6,7-tetrahydro-1-benzothien-3-ylcarbonyl)amino]-1,3-thiazole-5-carboxylate Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42383&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1245230 252623084 ZINC01053604 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79258 OC(=O)c1cccnc1SCCc1ccccc1 InChI=1S/C14H13NO2S/c16-14(17)12-7-4-9-15-13(12)18-10-8-11-5-2-1-3-6-11/h1-7,9H,8,10H2,(H,16,17) UZERZZRWECLIKE-UHFFFAOYSA-N 42384 2-(2-phenylethylsulfanyl)pyridine-3-carboxylic acid::2-(2-phenylethylthio)-3-pyridinecarboxylic acid::2-(phenethylthio)nicotinic acid::2-[(2-phenylethyl)thio]nicotinic acid::MLS000088004::SMR000072200::cid_888706 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42384&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 888706 252623085 ZINC00462764 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79259 CCn1c(SCC(=O)N2CCN(CC2)c2ccccc2)nnc1-c1cc2cc(Cl)ccc2o1 InChI=1S/C24H24ClN5O2S/c1-2-30-23(21-15-17-14-18(25)8-9-20(17)32-21)26-27-24(30)33-16-22(31)29-12-10-28(11-13-29)19-6-4-3-5-7-19/h3-9,14-15H,2,10-13,16H2,1H3 XHJCGKGBOXIPKJ-UHFFFAOYSA-N 42385 1-({[5-(5-chloro-1-benzofuran-2-yl)-4-ethyl-4H-1,2,4-triazol-3-yl]thio}acetyl)-4-phenylpiperazine::2-[[5-(5-chloranyl-1-benzofuran-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-phenylpiperazin-1-yl)ethanone::2-[[5-(5-chloro-1-benzofuran-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-phenylpiperazin-1-yl)ethanone::2-[[5-(5-chloro-2-benzofuranyl)-4-ethyl-1,2,4-triazol-3-yl]thio]-1-(4-phenyl-1-piperazinyl)ethanone::2-[[5-(5-chlorobenzofuran-2-yl)-4-ethyl-1,2,4-triazol-3-yl]thio]-1-(4-phenylpiperazino)ethanone::MLS000050220::SMR000077364::cid_2958440 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42385&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2958440 252623086 ZINC04058306 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79260 COc1ccc(Cc2nnc(SCC(=O)c3ccc(OC)cc3)o2)cc1 InChI=1S/C19H18N2O4S/c1-23-15-7-3-13(4-8-15)11-18-20-21-19(25-18)26-12-17(22)14-5-9-16(24-2)10-6-14/h3-10H,11-12H2,1-2H3 KHJHWKRZUOKNDJ-UHFFFAOYSA-N 42386 1-(4-methoxyphenyl)-2-[(5-p-anisyl-1,3,4-oxadiazol-2-yl)thio]ethanone::1-(4-methoxyphenyl)-2-[[5-[(4-methoxyphenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone::1-(4-methoxyphenyl)-2-[[5-[(4-methoxyphenyl)methyl]-1,3,4-oxadiazol-2-yl]thio]ethanone::2-{[5-(4-methoxybenzyl)-1,3,4-oxadiazol-2-yl]thio}-1-(4-methoxyphenyl)ethanone::MLS000051909::SMR000081060::cid_1076534 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42386&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1076534 252623087 ZINC00786021 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79261 Clc1cccc(NC(=O)Nc2ccc(CC#N)cc2)c1 InChI=1S/C15H12ClN3O/c16-12-2-1-3-14(10-12)19-15(20)18-13-6-4-11(5-7-13)8-9-17/h1-7,10H,8H2,(H2,18,19,20) FWYABNDIBQSDPB-UHFFFAOYSA-N 39489 1-(3-chlorophenyl)-3-[4-(cyanomethyl)phenyl]urea::MLS000100114::N-(3-chlorophenyl)-N'-[4-(cyanomethyl)phenyl]urea::SMR000081894::cid_1255527 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39489&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1255527 252620381 C04116 ZINC01066489 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79262 CCOC(=O)c1oc2c(C)c(O)ccc2c(=O)c1-c1nncn1-c1ccccc1 InChI=1S/C21H17N3O5/c1-3-28-21(27)19-16(17(26)14-9-10-15(25)12(2)18(14)29-19)20-23-22-11-24(20)13-7-5-4-6-8-13/h4-11,25H,3H2,1-2H3 CMKBGPWAWMYNPK-UHFFFAOYSA-N 42387 7-hydroxy-4-keto-8-methyl-3-(4-phenyl-1,2,4-triazol-3-yl)chromene-2-carboxylic acid ethyl ester::7-hydroxy-8-methyl-4-oxo-3-(4-phenyl-1,2,4-triazol-3-yl)-1-benzopyran-2-carboxylic acid ethyl ester::MLS000049887::SMR000076942::cid_5649178::ethyl 7-hydroxy-8-methyl-4-oxo-3-(4-phenyl-1,2,4-triazol-3-yl)chromene-2-carboxylate::ethyl 7-hydroxy-8-methyl-4-oxo-3-(4-phenyl-4H-1,2,4-triazol-3-yl)-4H-chromene-2-carboxylate::ethyl 8-methyl-7-oxidanyl-4-oxidanylidene-3-(4-phenyl-1,2,4-triazol-3-yl)chromene-2-carboxylate Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42387&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 5649178 252623088 ZINC04058594 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79263 O=C(CN1C(=O)c2ccccc2S1(=O)=O)NCCSC1CCCCC1 InChI=1S/C17H22N2O4S2/c20-16(18-10-11-24-13-6-2-1-3-7-13)12-19-17(21)14-8-4-5-9-15(14)25(19,22)23/h4-5,8-9,13H,1-3,6-7,10-12H2,(H,18,20) QRPPXKLQXGOYPG-UHFFFAOYSA-N 42388 MLS000254533::N-(2-cyclohexylsulfanylethyl)-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetamide::N-(2-cyclohexylsulfanylethyl)-2-[1,1,3-tris(oxidanylidene)-1,2-benzothiazol-2-yl]ethanamide::N-[2-(cyclohexylthio)ethyl]-2-(1,1,3-triketo-1,2-benzothiazol-2-yl)acetamide::N-[2-(cyclohexylthio)ethyl]-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetamide::N-[2-(cyclohexylthio)ethyl]-2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)acetamide::SMR000074801::cid_1994454 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42388&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1994454 252623089 ZINC02395683 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79264 CCOC(=O)N1CCC2(CC1)C(C#N)C(=N)Oc1c2c(C)nn1-c1cccc(Cl)c1 InChI=1S/C21H22ClN5O3/c1-3-29-20(28)26-9-7-21(8-10-26)16(12-23)18(24)30-19-17(21)13(2)25-27(19)15-6-4-5-14(22)11-15/h4-6,11,16,24H,3,7-10H2,1-2H3 UCLBLMBJMLGDCA-UHFFFAOYSA-N 42389 6'-amino-1'-(3-chlorophenyl)-5'-cyano-3'-methyl-1-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]carboxylic acid ethyl ester::6'-amino-1'-(3-chlorophenyl)-5'-cyano-3'-methyl-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-1-carboxylic acid ethyl ester::MLS000050713::SMR000078187::cid_2962025::ethyl 6'-amino-1'-(3-chlorophenyl)-5'-cyano-3'-methyl-1H,1'H-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-1-carboxylate::ethyl 6'-amino-1'-(3-chlorophenyl)-5'-cyano-3'-methylspiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-1-carboxylate::ethyl 6'-azanyl-1'-(3-chlorophenyl)-5'-cyano-3'-methyl-spiro[piperidine-4,4'-pyrano[2,3-c]pyrazole]-1-carboxylate Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42389&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 91896534 252623090 ZINC04196426 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79265 Cc1cc(C)cc(c1)N1CC(CC1=O)C(O)=O InChI=1S/C13H15NO3/c1-8-3-9(2)5-11(4-8)14-7-10(13(16)17)6-12(14)15/h3-5,10H,6-7H2,1-2H3,(H,16,17) ZVYUEYJQRCOJDI-UHFFFAOYSA-N 42390 1-(3,5-dimethylphenyl)-5-keto-pyrrolidine-3-carboxylic acid::1-(3,5-dimethylphenyl)-5-oxidanylidene-pyrrolidine-3-carboxylic acid::1-(3,5-dimethylphenyl)-5-oxo-3-pyrrolidinecarboxylic acid::1-(3,5-dimethylphenyl)-5-oxopyrrolidine-3-carboxylic acid::MLS000066230::SMR000079860::cid_2741834 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42390&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2741834 252623091 ZINC00112614 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79266 [O-]N1C2CCCCC2[N+](=O)C=C1c1ccc(Oc2ccccc2)cc1 InChI=1S/C20H20N2O3/c23-21-14-20(22(24)19-9-5-4-8-18(19)21)15-10-12-17(13-11-15)25-16-6-2-1-3-7-16/h1-3,6-7,10-14,18-19H,4-5,8-9H2 QUQPREFMDUPVMG-UHFFFAOYSA-N 40469 2-(4-phenoxyphenyl)-4a,5,6,7,8,8a-hexahydroquinoxaline 1,4-dioxide::4-oxidanidyl-3-(4-phenoxyphenyl)-4a,5,6,7,8,8a-hexahydroquinoxalin-1-ium 1-oxide::4-oxido-3-(4-phenoxyphenyl)-4a,5,6,7,8,8a-hexahydroquinoxalin-1-ium 1-oxide::MLS000051260::SMR000079265::cid_2966106 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40469&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2966106 252621294 ZINC13153067 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79267 CCn1c(CCNC(=O)c2ccc(Cl)cc2)nnc1SCC(=O)NC1CCCC1 InChI=1S/C20H26ClN5O2S/c1-2-26-17(11-12-22-19(28)14-7-9-15(21)10-8-14)24-25-20(26)29-13-18(27)23-16-5-3-4-6-16/h7-10,16H,2-6,11-13H2,1H3,(H,22,28)(H,23,27) RYVQRYUXUQZUPT-UHFFFAOYSA-N 42391 4-chloranyl-N-[2-[5-[2-(cyclopentylamino)-2-oxidanylidene-ethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]ethyl]benzamide::4-chloro-N-[2-(5-{[2-(cyclopentylamino)-2-oxoethyl]thio}-4-ethyl-4H-1,2,4-triazol-3-yl)ethyl]benzamide::4-chloro-N-[2-[5-[2-(cyclopentylamino)-2-oxoethyl]sulfanyl-4-ethyl-1,2,4-triazol-3-yl]ethyl]benzamide::4-chloro-N-[2-[5-[[2-(cyclopentylamino)-2-keto-ethyl]thio]-4-ethyl-1,2,4-triazol-3-yl]ethyl]benzamide::4-chloro-N-[2-[5-[[2-(cyclopentylamino)-2-oxoethyl]thio]-4-ethyl-1,2,4-triazol-3-yl]ethyl]benzamide::MLS000050352::SMR000077613::cid_2959770 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42391&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2959770 252623092 ZINC04196556 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79268 COc1ccc(cc1OC)C(=O)n1nc(nc1N)-c1ccccc1 InChI=1S/C17H16N4O3/c1-23-13-9-8-12(10-14(13)24-2)16(22)21-17(18)19-15(20-21)11-6-4-3-5-7-11/h3-10H,1-2H3,(H2,18,19,20) KJFHJZMOFADPOP-UHFFFAOYSA-N 33437 (5-amino-3-phenyl-1,2,4-triazol-1-yl)-(3,4-dimethoxyphenyl)methanone::(5-azanyl-3-phenyl-1,2,4-triazol-1-yl)-(3,4-dimethoxyphenyl)methanone::1-(3,4-dimethoxybenzoyl)-3-phenyl-1H-1,2,4-triazol-5-amine::MLS000099650::SMR000074479::cid_975107 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=33437&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 975107 252616345 ZINC00616457 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79269 COC(=O)c1cn(C(=O)c2cccs2)c2ccccc12 InChI=1S/C15H11NO3S/c1-19-15(18)11-9-16(12-6-3-2-5-10(11)12)14(17)13-7-4-8-20-13/h2-9H,1H3 MUEWTXJMZDEHDX-UHFFFAOYSA-N 42392 1-(2-thenoyl)indole-3-carboxylic acid methyl ester::1-[oxo(thiophen-2-yl)methyl]-3-indolecarboxylic acid methyl ester::MLS000061941::SMR000070802::cid_702931::methyl 1-(2-thienylcarbonyl)-1H-indole-3-carboxylate::methyl 1-(thiophene-2-carbonyl)indole-3-carboxylate::methyl 1-thiophen-2-ylcarbonylindole-3-carboxylate Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42392&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 702931 252623093 ZINC00085390 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79270 CC(=O)c1ccc(NC(=O)CSCCO)cc1 InChI=1S/C12H15NO3S/c1-9(15)10-2-4-11(5-3-10)13-12(16)8-17-7-6-14/h2-5,14H,6-8H2,1H3,(H,13,16) PXGXPOMBCLKALX-UHFFFAOYSA-N 42393 MLS000088702::N-(4-acetylphenyl)-2-(2-hydroxyethylsulfanyl)acetamide::N-(4-acetylphenyl)-2-(2-hydroxyethylthio)acetamide::N-(4-acetylphenyl)-2-[(2-hydroxyethyl)thio]acetamide::N-(4-ethanoylphenyl)-2-(2-hydroxyethylsulfanyl)ethanamide::SMR000072719::cid_2190575 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42393&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2190575 252623094 ZINC02833224 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79271 CCOC(=O)c1c(C)n(C)c2ccc(OC(C)C(=O)OC)cc12 InChI=1S/C17H21NO5/c1-6-22-17(20)15-10(2)18(4)14-8-7-12(9-13(14)15)23-11(3)16(19)21-5/h7-9,11H,6H2,1-5H3 XRVSJLSOULINGX-UHFFFAOYSA-N 42394 5-(1-methoxy-1-oxopropan-2-yl)oxy-1,2-dimethyl-3-indolecarboxylic acid ethyl ester::5-(2-keto-2-methoxy-1-methyl-ethoxy)-1,2-dimethyl-indole-3-carboxylic acid ethyl ester::MLS000061959::SMR000070820::cid_2892134::ethyl 5-(1-methoxy-1-oxidanylidene-propan-2-yl)oxy-1,2-dimethyl-indole-3-carboxylate::ethyl 5-(1-methoxy-1-oxopropan-2-yl)oxy-1,2-dimethylindole-3-carboxylate::ethyl 5-(2-methoxy-1-methyl-2-oxoethoxy)-1,2-dimethyl-1H-indole-3-carboxylate Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42394&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2892134 252623095 ZINC00096591 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79272 Cn1c(Cc2ccccc2)nnc1SCC(=O)Nc1ccccc1N1CCOCC1 InChI=1S/C22H25N5O2S/c1-26-20(15-17-7-3-2-4-8-17)24-25-22(26)30-16-21(28)23-18-9-5-6-10-19(18)27-11-13-29-14-12-27/h2-10H,11-16H2,1H3,(H,23,28) PUFRVAXJGCICDW-UHFFFAOYSA-N 42395 2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-morpholin-4-ylphenyl)acetamide::2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)thio]-N-(2-morpholinophenyl)acetamide::2-[(5-benzyl-4-methyl-4H-1,2,4-triazol-3-yl)thio]-N-[2-(4-morpholinyl)phenyl]acetamide::2-[[4-methyl-5-(phenylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-morpholin-4-ylphenyl)ethanamide::2-[[4-methyl-5-(phenylmethyl)-1,2,4-triazol-3-yl]thio]-N-[2-(4-morpholinyl)phenyl]acetamide::MLS000097365::SMR000076001::cid_1088664 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42395&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1088664 252623096 ZINC00807412 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544551 OC[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C8H15NO3/c10-4-5-7(12)6(11)3-9-8(5)1-2-8/h5-7,9-12H,1-4H2/t5-,6-,7-/m1/s1 UVWFVBWKBBONDJ-FSDSQADBSA-N 285820 (6R,7R,8R)-8-(hydroxymethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 2::US9796680, Example 2 Lysosomal acid glucosylceramidase Homo sapiens 7.00 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285820&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197685 378169457 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544552 O[C@@H]1CNC2(CC2)[C@H](CF)[C@H]1O InChI=1S/C8H14FNO2/c9-3-5-7(12)6(11)4-10-8(5)1-2-8/h5-7,10-12H,1-4H2/t5-,6-,7-/m1/s1 MFUFEXHORIKDTD-FSDSQADBSA-N 285821 (6R,7R,8S)-8-(fluoromethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 3::US9796680, Example 3 Lysosomal acid glucosylceramidase Homo sapiens 6.20 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285821&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 91810852 378169458 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544553 O[C@@H]1CNC2(CC2)[C@H](CF)[C@H]1O InChI=1S/C8H14FNO2/c9-3-5-7(12)6(11)4-10-8(5)1-2-8/h5-7,10-12H,1-4H2/t5-,6-,7-/m1/s1 MFUFEXHORIKDTD-FSDSQADBSA-N 285821 (6R,7R,8S)-8-(fluoromethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 3::US9796680, Example 3 Lysosomal acid glucosylceramidase Homo sapiens 2.10 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285821&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 91810852 378169458 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544554 O[C@@H]1CNC2(CC2)[C@H](C(F)F)[C@H]1O InChI=1S/C8H13F2NO2/c9-7(10)5-6(13)4(12)3-11-8(5)1-2-8/h4-7,11-13H,1-3H2/t4-,5+,6+/m1/s1 HNWFXDPDLGNHIM-SRQIZXRXSA-N 285822 (6R,7R,8S)-8-(difluoromethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 4::US9796680, Example 4 Lysosomal acid glucosylceramidase Homo sapiens 6.50 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285822&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197634 378169459 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544555 O[C@@H]1CNC2(CC2)[C@H](C(F)F)[C@H]1O InChI=1S/C8H13F2NO2/c9-7(10)5-6(13)4(12)3-11-8(5)1-2-8/h4-7,11-13H,1-3H2/t4-,5+,6+/m1/s1 HNWFXDPDLGNHIM-SRQIZXRXSA-N 285822 (6R,7R,8S)-8-(difluoromethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 4::US9796680, Example 4 Lysosomal acid glucosylceramidase Homo sapiens 8.00 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285822&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197634 378169459 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544556 O[C@@H]1CNC2(CC2)[C@H](CCl)[C@H]1O InChI=1S/C8H14ClNO2/c9-3-5-7(12)6(11)4-10-8(5)1-2-8/h5-7,10-12H,1-4H2/t5-,6-,7-/m1/s1 PJBIJTLFOHTQLS-FSDSQADBSA-N 285823 (6R,7R,8S)-8-(chloromethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 5::US9796680, Example 5 Lysosomal acid glucosylceramidase Homo sapiens 7.40 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285823&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197606 378169460 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544557 COC[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C9H17NO3/c1-13-5-6-8(12)7(11)4-10-9(6)2-3-9/h6-8,10-12H,2-5H2,1H3/t6-,7-,8-/m1/s1 UREIBDHTHIOCAG-BWZBUEFSSA-N 285824 (6R,7R,8R)-8-(methoxymethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 6::US9796680, Example 6 Lysosomal acid glucosylceramidase Homo sapiens 7.50 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285824&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197605 378169461 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544558 CO[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C8H15NO3/c1-12-7-6(11)5(10)4-9-8(7)2-3-8/h5-7,9-11H,2-4H2,1H3/t5-,6+,7-/m1/s1 TYUVSEJCCYQRRS-DSYKOEDSSA-N 285825 (6R,7S,8S)-8-methoxy-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 7::US9796680, Example 7 Lysosomal acid glucosylceramidase Homo sapiens 32.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285825&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197644 378169462 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544559 O[C@@H]1CNC2(CC2)[C@H](C#N)[C@H]1O InChI=1S/C8H12N2O2/c9-3-5-7(12)6(11)4-10-8(5)1-2-8/h5-7,10-12H,1-2,4H2/t5-,6-,7-/m1/s1 WOKVFVFSTFFEDJ-FSDSQADBSA-N 285826 (6R,7R,8R)-6,7-dihydroxy-4-azaspiro[2.5]octane-8-carbonitrile::US10081601, Example 8::US9796680, Example 8 Lysosomal acid glucosylceramidase Homo sapiens 75.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285826&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197607 378169463 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544560 O[C@@H]1CNC2(CC2)[C@@H]([C@H]1O)C(O)=O InChI=1S/C8H13NO4/c10-4-3-9-8(1-2-8)5(6(4)11)7(12)13/h4-6,9-11H,1-3H2,(H,12,13)/t4-,5+,6+/m1/s1 JOBWNRYDTOZDMC-SRQIZXRXSA-N 285827 (6R,7R,8S)-6,7-dihydroxy-4-azaspiro[2.5]octane-8-carboxylic acid::US10081601, Example 9::US9796680, Example 9 Lysosomal acid glucosylceramidase Homo sapiens 507 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285827&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197645 378169464 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544561 CNC(=O)[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C9H16N2O3/c1-10-8(14)6-7(13)5(12)4-11-9(6)2-3-9/h5-7,11-13H,2-4H2,1H3,(H,10,14)/t5-,6+,7+/m1/s1 JIXJUDKLYVZZEK-VQVTYTSYSA-N 285828 (6R,7R,8S)-6,7-dihydroxy-N-methyl-4-azaspiro[2.5]octane-8-carboxamide::US10081601, Example 10::US9796680, Example 10 Lysosomal acid glucosylceramidase Homo sapiens 264 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285828&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197617 378169465 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544562 O[C@@H]1CNC2(CC2)[C@@H]([C@H]1O)C(=O)NC1CC1 InChI=1S/C11H18N2O3/c14-7-5-12-11(3-4-11)8(9(7)15)10(16)13-6-1-2-6/h6-9,12,14-15H,1-5H2,(H,13,16)/t7-,8+,9+/m1/s1 OZMBWHOGRHGGHS-VGMNWLOBSA-N 285829 (6R,7R,8S)—N-cyclopropyl-6,7-dihydroxy-4-azaspiro[2.5]octane-8-carboxamide::US10081601, Example 11::US9796680, Example 11 Lysosomal acid glucosylceramidase Homo sapiens 462 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285829&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197783 378169466 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544563 CC[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C9H17NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h6-8,10-12H,2-5H2,1H3/t6-,7-,8-/m1/s1 LYPUWEGFMHAGTQ-BWZBUEFSSA-N 285830 (6R,7R,8S)-8-ethyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 12::US9796680, Example 12 Lysosomal acid glucosylceramidase Homo sapiens 6.30 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285830&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197652 378169467 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79273 CCN(CC)S(=O)(=O)c1ccc(NC(=O)CN(c2cccc(F)c2)S(C)(=O)=O)cc1 InChI=1S/C19H24FN3O5S2/c1-4-22(5-2)30(27,28)18-11-9-16(10-12-18)21-19(24)14-23(29(3,25)26)17-8-6-7-15(20)13-17/h6-13H,4-5,14H2,1-3H3,(H,21,24) NXUPZMKZPIKYFD-UHFFFAOYSA-N 42396 MLS000050546::N-[4-(diethylsulfamoyl)phenyl]-2-(3-fluoro-N-mesyl-anilino)acetamide::N-[4-(diethylsulfamoyl)phenyl]-2-(3-fluoro-N-methylsulfonylanilino)acetamide::N-[4-(diethylsulfamoyl)phenyl]-2-[(3-fluorophenyl)-methylsulfonyl-amino]ethanamide::N~1~-{4-[(diethylamino)sulfonyl]phenyl}-N~2~-(3-fluorophenyl)-N~2~-(methylsulfonyl)glycinamide::SMR000076501::cid_1295669 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42396&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1295669 252623097 ZINC01118490 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79274 Cc1oc(cc1COc1ccccc1)C(=O)Nc1ccc(O)cc1 InChI=1S/C19H17NO4/c1-13-14(12-23-17-5-3-2-4-6-17)11-18(24-13)19(22)20-15-7-9-16(21)10-8-15/h2-11,21H,12H2,1H3,(H,20,22) ZJFWEPODJBPURP-UHFFFAOYSA-N 42397 MLS000066799::N-(4-hydroxyphenyl)-5-methyl-4-(phenoxymethyl)-2-furamide::N-(4-hydroxyphenyl)-5-methyl-4-(phenoxymethyl)-2-furancarboxamide::N-(4-hydroxyphenyl)-5-methyl-4-(phenoxymethyl)furan-2-carboxamide::SMR000070408::cid_877453 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42397&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 877453 252623098 ZINC00446427 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79275 O=C(CN1CCOCC1)N1CCN(C1)S(=O)(=O)c1ccccc1 InChI=1S/C15H21N3O4S/c19-15(12-16-8-10-22-11-9-16)17-6-7-18(13-17)23(20,21)14-4-2-1-3-5-14/h1-5H,6-13H2 QAXBAVPFXQUSCT-UHFFFAOYSA-N 42398 1-(3-besylimidazolidin-1-yl)-2-morpholino-ethanone::1-[3-(benzenesulfonyl)-1-imidazolidinyl]-2-(4-morpholinyl)ethanone::1-[3-(benzenesulfonyl)imidazolidin-1-yl]-2-morpholin-4-ylethanone::2-morpholin-4-yl-1-[3-(phenylsulfonyl)imidazolidin-1-yl]ethanone::4-{2-oxo-2-[3-(phenylsulfonyl)-1-imidazolidinyl]ethyl}morpholine::MLS000088741::SMR000072764::cid_747981 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42398&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 747981 252623099 ZINC19373655 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79276 CCCCSc1nnc(o1)-c1ccc(C)cc1 InChI=1S/C13H16N2OS/c1-3-4-9-17-13-15-14-12(16-13)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3 JPAWHIGGTVOTJC-UHFFFAOYSA-N 42399 2-(butylthio)-5-(4-methylphenyl)-1,3,4-oxadiazole::2-(butylthio)-5-(p-tolyl)-1,3,4-oxadiazole::2-butylsulfanyl-5-(4-methylphenyl)-1,3,4-oxadiazole::MLS000063529::SMR000072528::cid_2188596 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42399&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2188596 252623100 ZINC02830346 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79277 C\N=C1\SC(CC(=O)Nc2cccc(c2)C(F)(F)F)C(=O)N1C InChI=1S/C14H14F3N3O2S/c1-18-13-20(2)12(22)10(23-13)7-11(21)19-9-5-3-4-8(6-9)14(15,16)17/h3-6,10H,7H2,1-2H3,(H,19,21)/b18-13+ RQNSMEBTBJWQAR-QGOAFFKASA-N 42400 2-(3-methyl-2-methylimino-4-oxidanylidene-1,3-thiazolidin-5-yl)-N-[3-(trifluoromethyl)phenyl]ethanamide::2-(3-methyl-2-methylimino-4-oxo-1,3-thiazolidin-5-yl)-N-[3-(trifluoromethyl)phenyl]acetamide::2-(3-methyl-2-methylimino-4-oxo-5-thiazolidinyl)-N-[3-(trifluoromethyl)phenyl]acetamide::2-(4-keto-3-methyl-2-methylimino-thiazolidin-5-yl)-N-[3-(trifluoromethyl)phenyl]acetamide::2-[3-methyl-2-(methylimino)-4-oxo-1,3-thiazolidin-5-yl]-N-[3-(trifluoromethyl)phenyl]acetamide::MLS000088602::SMR000072592::cid_2939431 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42400&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2939431 252623101 ZINC13153490 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79278 Cc1cc(NS(=O)(=O)c2ccc(NC(=O)CCN3C(=O)c4ccccc4C3=O)cc2)no1 InChI=1S/C21H18N4O6S/c1-13-12-18(23-31-13)24-32(29,30)15-8-6-14(7-9-15)22-19(26)10-11-25-20(27)16-4-2-3-5-17(16)21(25)28/h2-9,12H,10-11H2,1H3,(H,22,26)(H,23,24) LIQPVKLDLTXVJS-UHFFFAOYSA-N 42401 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(4-{[(5-methyl-3-isoxazolyl)amino]sulfonyl}phenyl)propanamide::3-(1,3-dioxo-2-isoindolyl)-N-[4-[(5-methyl-3-isoxazolyl)sulfamoyl]phenyl]propanamide::3-(1,3-dioxoisoindol-2-yl)-N-[4-[(5-methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]propanamide::3-[1,3-bis(oxidanylidene)isoindol-2-yl]-N-[4-[(5-methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]propanamide::MLS000050270::N-[4-[(5-methylisoxazol-3-yl)sulfamoyl]phenyl]-3-phthalimido-propionamide::SMR000077451::cid_2213836 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42401&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2213836 252623102 ZINC02860654 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79279 Cc1ccc2N[C@@H]([C@@H]3CCO[C@@H]3c2c1)c1ccncc1 InChI=1S/C17H18N2O/c1-11-2-3-15-14(10-11)17-13(6-9-20-17)16(19-15)12-4-7-18-8-5-12/h2-5,7-8,10,13,16-17,19H,6,9H2,1H3/t13-,16+,17-/m0/s1 YZFLWQYXBOQANK-XKQJLSEDSA-N 42402 (3aS,4S,9bS)-8-methyl-4-(4-pyridyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline::(3aS,4S,9bS)-8-methyl-4-pyridin-4-yl-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline::MLS000115006::SMR000092269::cid_5308449 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42402&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 5308449 252623103 ZINC04004247 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79280 C=CCSC1=N\C(=C/c2ccsc2)C(=O)S1 InChI=1S/C11H9NOS3/c1-2-4-15-11-12-9(10(13)16-11)6-8-3-5-14-7-8/h2-3,5-7H,1,4H2/b9-6- SZTGXTIRCQBOKL-TWGQIWQCSA-N 42403 (4Z)-2-(allylthio)-4-(3-thenylidene)-2-thiazolin-5-one::(4Z)-2-(prop-2-enylthio)-4-(3-thiophenylmethylidene)-5-thiazolone::(4Z)-2-prop-2-enylsulfanyl-4-(thiophen-3-ylmethylidene)-1,3-thiazol-5-one::MLS000113177::SMR000109083::cid_2299642 Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42403&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2299642 252623104 ZINC04845378 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79281 COc1ccc(cc1OC)C(=O)N1CCC(CC1)C(=O)Nc1cccc(C)c1 InChI=1S/C22H26N2O4/c1-15-5-4-6-18(13-15)23-21(25)16-9-11-24(12-10-16)22(26)17-7-8-19(27-2)20(14-17)28-3/h4-8,13-14,16H,9-12H2,1-3H3,(H,23,25) DFMCOYJIVZURGA-UHFFFAOYSA-N 42404 1-(3,4-dimethoxybenzoyl)-N-(3-methylphenyl)piperidine-4-carboxamide::1-(3,4-dimethoxyphenyl)carbonyl-N-(3-methylphenyl)piperidine-4-carboxamide::1-[(3,4-dimethoxyphenyl)-oxomethyl]-N-(3-methylphenyl)-4-piperidinecarboxamide::MLS000112720::N-(m-tolyl)-1-veratroyl-isonipecotamide::SMR000108630::cid_1327311 Lysosomal acid glucosylceramidase Homo sapiens >10000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42404&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1327311 252623105 ZINC01158197 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79282 O=S(=O)(NC1C(N2CCNCC2)c2cccc3cccc1c23)c1ccccc1 InChI=1S/C22H23N3O2S/c26-28(27,17-8-2-1-3-9-17)24-21-18-10-4-6-16-7-5-11-19(20(16)18)22(21)25-14-12-23-13-15-25/h1-11,21-24H,12-15H2 DFHHBGRWPZJXGB-UHFFFAOYSA-N 42405 MLS000110376::N-(2-piperazin-1-yl-1,2-dihydroacenaphthylen-1-yl)benzenesulfonamide::N-(2-piperazinoacenaphthen-1-yl)benzenesulfonamide::N-[2-(1-piperazinyl)-1,2-dihydroacenaphthylen-1-yl]benzenesulfonamide::SMR000106306::cid_2898054 Lysosomal acid glucosylceramidase Homo sapiens 1665 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42405&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2898054 252623106 ZINC19810997 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 79283 COC(=O)c1cn(nc1-c1cccnc1)-c1ccccc1 InChI=1S/C16H13N3O2/c1-21-16(20)14-11-19(13-7-3-2-4-8-13)18-15(14)12-6-5-9-17-10-12/h2-11H,1H3 FHRFYYRLSIONME-UHFFFAOYSA-N 42406 1-phenyl-3-(3-pyridinyl)-4-pyrazolecarboxylic acid methyl ester::1-phenyl-3-(3-pyridyl)pyrazole-4-carboxylic acid methyl ester::MLS000110650::SMR000106579::cid_752167::methyl 1-phenyl-3-pyridin-3-yl-pyrazole-4-carboxylate::methyl 1-phenyl-3-pyridin-3-ylpyrazole-4-carboxylate Lysosomal acid glucosylceramidase Homo sapiens >50000 PubChem 10.7270/Q23J3BC8 aid1268 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42406&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 752167 252623107 ZINC00203002 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 169703 Cc1ccc(Sc2cccc3nc(N)nc(N)c23)cc1 InChI=1S/C15H14N4S/c1-9-5-7-10(8-6-9)20-12-4-2-3-11-13(12)14(16)19-15(17)18-11/h2-8H,1H3,(H4,16,17,18,19) UOJFGEAPSYQDIP-UHFFFAOYSA-N 18046 5-((4-methylphenyl)thio)-quinazoline 2,4-diamine, 1::5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE::5-[(4-methylphenyl)sulfanyl]quinazoline-2,4-diamine::5-[(4-methylphenyl)sulfanyl]quinazoline-2,4-diamine, 2c::CHEMBL83547::GW578 Lysosomal acid glucosylceramidase Homo sapiens 7.8e+3 5.5 37.00 C Curated from the literature by BindingDB 10.1002/cbic.200800304 10.7270/Q2JQ0ZJK 18972510 aid1799623 Tropak, MB; Kornhaber, GJ; Rigat, BA; Maegawa, GH; Buttner, JD; Blanchard, JE; Murphy, C; Tuske, SJ; Coales, SJ; Hamuro, Y; Brown, ED; Mahuran, DJ Research Institute, Hospital for Sick Children http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18046&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search TQ4 1IA2 446245 46518162 CHEMBL83547 DB04306 ZINC00172633 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 169704 Nc1nc(N)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C8H7N5O2/c9-7-5-3-4(13(14)15)1-2-6(5)11-8(10)12-7/h1-3H,(H4,9,10,11,12) YZMJNZRTRWPJFY-UHFFFAOYSA-N 84608 2,4-diamino-6-nitro-quinazoline, 1a Lysosomal acid glucosylceramidase Homo sapiens 6.1e+4 5.5 37.00 C Curated from the literature by BindingDB 10.1002/cbic.200800304 10.7270/Q2JQ0ZJK 18972510 aid1799623 Tropak, MB; Kornhaber, GJ; Rigat, BA; Maegawa, GH; Buttner, JD; Blanchard, JE; Murphy, C; Tuske, SJ; Coales, SJ; Hamuro, Y; Brown, ED; Mahuran, DJ Research Institute, Hospital for Sick Children http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84608&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 252163 136350708 ZINC04243021 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 169705 CCOc1ccc2c(N)nc(N)nc2c1OCC InChI=1S/C12H16N4O2/c1-3-17-8-6-5-7-9(10(8)18-4-2)15-12(14)16-11(7)13/h5-6H,3-4H2,1-2H3,(H4,13,14,15,16) BDSMCJIJTNSCNV-UHFFFAOYSA-N 84609 7,8-diethoxy-quinazoline 2,4-diamine, 1b Lysosomal acid glucosylceramidase Homo sapiens 2.2e+4 5.5 37.00 C Curated from the literature by BindingDB 10.1002/cbic.200800304 10.7270/Q2JQ0ZJK 18972510 aid1799623 Tropak, MB; Kornhaber, GJ; Rigat, BA; Maegawa, GH; Buttner, JD; Blanchard, JE; Murphy, C; Tuske, SJ; Coales, SJ; Hamuro, Y; Brown, ED; Mahuran, DJ Research Institute, Hospital for Sick Children http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84609&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4643925 136350709 ZINC00406010 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 169706 Clc1cc(Cl)cc(Oc2ccc(o2)C(=O)Nc2ccncc2)c1 InChI=1S/C16H10Cl2N2O3/c17-10-7-11(18)9-13(8-10)22-15-2-1-14(23-15)16(21)20-12-3-5-19-6-4-12/h1-9H,(H,19,20,21) FRDJJGSXDLUKPF-UHFFFAOYSA-N 84610 5-(3,5-dichlorophenoxy)-N-(4-pyrdinyl)-2- furamide, 2 Lysosomal acid glucosylceramidase Homo sapiens 4.7e+3 5.5 37.00 C Curated from the literature by BindingDB 10.1002/cbic.200800304 10.7270/Q2JQ0ZJK 18972510 aid1799623 Tropak, MB; Kornhaber, GJ; Rigat, BA; Maegawa, GH; Buttner, JD; Blanchard, JE; Murphy, C; Tuske, SJ; Coales, SJ; Hamuro, Y; Brown, ED; Mahuran, DJ Research Institute, Hospital for Sick Children http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84610&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2810641 136350710 ZINC00146244 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 169707 Cc1ccccc1C(=O)Nc1ccncc1 InChI=1S/C13H12N2O/c1-10-4-2-3-5-12(10)13(16)15-11-6-8-14-9-7-11/h2-9H,1H3,(H,14,15,16) IPNZONAZPKLNST-UHFFFAOYSA-N 84611 2-methyl-N-pyridin-4-yl-benzamide, 2a Lysosomal acid glucosylceramidase Homo sapiens 8.0e+4 5.5 37.00 C Curated from the literature by BindingDB 10.1002/cbic.200800304 10.7270/Q2JQ0ZJK 18972510 aid1799623 Tropak, MB; Kornhaber, GJ; Rigat, BA; Maegawa, GH; Buttner, JD; Blanchard, JE; Murphy, C; Tuske, SJ; Coales, SJ; Hamuro, Y; Brown, ED; Mahuran, DJ Research Institute, Hospital for Sick Children http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84611&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4250390 136350711 ZINC00406453 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 169708 CC(C)(C)C(=O)Nc1ccncc1 InChI=1S/C10H14N2O/c1-10(2,3)9(13)12-8-4-6-11-7-5-8/h4-7H,1-3H3,(H,11,12,13) JCMMVFHXRDNILC-UHFFFAOYSA-N 84612 2,2-dimethyl-N-(4-pyridinyl)propanamide, 2b Lysosomal acid glucosylceramidase Homo sapiens >4.00e+5 5.5 37.00 C Curated from the literature by BindingDB 10.1002/cbic.200800304 10.7270/Q2JQ0ZJK 18972510 aid1799623 Tropak, MB; Kornhaber, GJ; Rigat, BA; Maegawa, GH; Buttner, JD; Blanchard, JE; Murphy, C; Tuske, SJ; Coales, SJ; Hamuro, Y; Brown, ED; Mahuran, DJ Research Institute, Hospital for Sick Children http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84612&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 427059 136350712 ZINC00161808 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 174644 OCC1CNCC(O)C1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2 QPYJXFZUIJOGNX-UHFFFAOYSA-N 50075408 5-(hydroxymethyl)piperidine-3,4-diol::CHEMBL345129::Isofagomine derivative, 3 Lysosomal acid glucosylceramidase Homo sapiens 23 5.5 Curated from the literature by BindingDB 10.1002/cbic.201100332 10.7270/Q2WD3Z3W 21751327 aid1799647 Hill, T; Tropak, MB; Mahuran, D; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075408&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search GIF 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 4452693 103968508 CHEMBL345129 ZINC06361564 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 174645 CCCC1NCC(O)C(O)C1CO InChI=1S/C9H19NO3/c1-2-3-7-6(5-11)9(13)8(12)4-10-7/h6-13H,2-5H2,1H3 DTUBZWJLYNQNGD-UHFFFAOYSA-N 85131 Isofagomine derivative, 6 Lysosomal acid glucosylceramidase Homo sapiens 610 5.5 Curated from the literature by BindingDB 10.1002/cbic.201100332 10.7270/Q2WD3Z3W 21751327 aid1799647 Hill, T; Tropak, MB; Mahuran, D; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85131&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57340001 136351231 ZINC87722652 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 174646 CCCC1(CCC)NCC(O)C(O)C1CO InChI=1S/C12H25NO3/c1-3-5-12(6-4-2)9(8-14)11(16)10(15)7-13-12/h9-11,13-16H,3-8H2,1-2H3 GZJQITPDATVFSD-UHFFFAOYSA-N 85132 Isofagomine derivative, 8 Lysosomal acid glucosylceramidase Homo sapiens 600 5.5 Curated from the literature by BindingDB 10.1002/cbic.201100332 10.7270/Q2WD3Z3W 21751327 aid1799647 Hill, T; Tropak, MB; Mahuran, D; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85132&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57340002 136351232 ZINC89456074 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 174647 OCCCC1NCC(O)C(O)C1CO InChI=1S/C9H19NO4/c11-3-1-2-7-6(5-12)9(14)8(13)4-10-7/h6-14H,1-5H2 ONRQATVXGSHIBI-UHFFFAOYSA-N 85133 Isofagomine derivative, 10 Lysosomal acid glucosylceramidase Homo sapiens 100 5.5 Curated from the literature by BindingDB 10.1002/cbic.201100332 10.7270/Q2WD3Z3W 21751327 aid1799647 Hill, T; Tropak, MB; Mahuran, D; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85133&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57340003 136351233 ZINC87722662 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 174648 CCCCCCCCCC1NCC(O)C(O)C1CO InChI=1S/C15H31NO3/c1-2-3-4-5-6-7-8-9-13-12(11-17)15(19)14(18)10-16-13/h12-19H,2-11H2,1H3 FAUJNJKIHJSYDO-UHFFFAOYSA-N 85134 Isofagomine derivative, 7 Lysosomal acid glucosylceramidase Homo sapiens 0.2 5.5 Curated from the literature by BindingDB 10.1002/cbic.201100332 10.7270/Q2WD3Z3W 21751327 aid1799647 Hill, T; Tropak, MB; Mahuran, D; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85134&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57340004 136351234 ZINC89456084 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 174649 OCC1CNCC(O)C1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2 QPYJXFZUIJOGNX-UHFFFAOYSA-N 50075408 5-(hydroxymethyl)piperidine-3,4-diol::CHEMBL345129::Isofagomine derivative, 3 Lysosomal acid glucosylceramidase Homo sapiens 5 7 Curated from the literature by BindingDB 10.1002/cbic.201100332 10.7270/Q2WD3Z3W 21751327 aid1799647 Hill, T; Tropak, MB; Mahuran, D; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075408&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search GIF 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 4452693 103968508 CHEMBL345129 ZINC06361564 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 174650 CCCC1NCC(O)C(O)C1CO InChI=1S/C9H19NO3/c1-2-3-7-6(5-11)9(13)8(12)4-10-7/h6-13H,2-5H2,1H3 DTUBZWJLYNQNGD-UHFFFAOYSA-N 85131 Isofagomine derivative, 6 Lysosomal acid glucosylceramidase Homo sapiens 210 7 Curated from the literature by BindingDB 10.1002/cbic.201100332 10.7270/Q2WD3Z3W 21751327 aid1799647 Hill, T; Tropak, MB; Mahuran, D; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85131&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57340001 136351231 ZINC87722652 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 174651 CCCC1(CCC)NCC(O)C(O)C1CO InChI=1S/C12H25NO3/c1-3-5-12(6-4-2)9(8-14)11(16)10(15)7-13-12/h9-11,13-16H,3-8H2,1-2H3 GZJQITPDATVFSD-UHFFFAOYSA-N 85132 Isofagomine derivative, 8 Lysosomal acid glucosylceramidase Homo sapiens 1400 7 Curated from the literature by BindingDB 10.1002/cbic.201100332 10.7270/Q2WD3Z3W 21751327 aid1799647 Hill, T; Tropak, MB; Mahuran, D; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85132&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57340002 136351232 ZINC89456074 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 174652 OCCCC1NCC(O)C(O)C1CO InChI=1S/C9H19NO4/c11-3-1-2-7-6(5-12)9(14)8(13)4-10-7/h6-14H,1-5H2 ONRQATVXGSHIBI-UHFFFAOYSA-N 85133 Isofagomine derivative, 10 Lysosomal acid glucosylceramidase Homo sapiens 110 7 Curated from the literature by BindingDB 10.1002/cbic.201100332 10.7270/Q2WD3Z3W 21751327 aid1799647 Hill, T; Tropak, MB; Mahuran, D; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85133&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57340003 136351233 ZINC87722662 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 174653 CCCCCCCCCC1NCC(O)C(O)C1CO InChI=1S/C15H31NO3/c1-2-3-4-5-6-7-8-9-13-12(11-17)15(19)14(18)10-16-13/h12-19H,2-11H2,1H3 FAUJNJKIHJSYDO-UHFFFAOYSA-N 85134 Isofagomine derivative, 7 Lysosomal acid glucosylceramidase Homo sapiens 0.07 7 Curated from the literature by BindingDB 10.1002/cbic.201100332 10.7270/Q2WD3Z3W 21751327 aid1799647 Hill, T; Tropak, MB; Mahuran, D; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85134&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57340004 136351234 ZINC89456084 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 198710 CC[C@@H](F)C1CNC[C@@H](O)[C@@H]1O InChI=1S/C8H16FNO2/c1-2-6(9)5-3-10-4-7(11)8(5)12/h5-8,10-12H,2-4H2,1H3/t5?,6-,7-,8-/m1/s1 JJOAXUOFRVBCHL-UIYHXYAWSA-N 47182 US8604206, (3R,4R,5S)-5-((R)-1-fluoropropyl)-piperidine-3,4-diol hydrochloride Lysosomal acid glucosylceramidase Homo sapiens 121 291 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47182&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 91824849 252148188 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 198711 CC[C@@H](F)C1CNC[C@@H](O)[C@@H]1O InChI=1S/C8H16FNO2/c1-2-6(9)5-3-10-4-7(11)8(5)12/h5-8,10-12H,2-4H2,1H3/t5?,6-,7-,8-/m1/s1 JJOAXUOFRVBCHL-UIYHXYAWSA-N 47182 US8604206, (3R,4R,5S)-5-((R)-1-fluoropropyl)-piperidine-3,4-diol hydrochloride Lysosomal acid glucosylceramidase Homo sapiens 31 60 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47182&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 91824849 252148188 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 201862 COc1ccc(cc1)C1=[N+]2C(C=C1)=C(CCCCc1cn(C[C@H]3[C@H]4O[C@H]4[C@H](O)[C@@H](O)[C@@H]3O)nn1)c1ccc(-c3ccc(OC)cc3)n1[B-]2(F)F InChI=1S/C36H38BF2N5O6/c1-48-24-11-7-21(8-12-24)28-15-17-30-26(31-18-16-29(44(31)37(38,39)43(28)30)22-9-13-25(49-2)14-10-22)6-4-3-5-23-19-42(41-40-23)20-27-32(45)33(46)34(47)36-35(27)50-36/h7-19,27,32-36,45-47H,3-6,20H2,1-2H3/t27-,32-,33+,34-,35-,36+/m1/s1 OWVDUFOFLDIMAR-SVBJHREWSA-N 60418 US9056847, Fluorophore 2-cyclophellitol Lysosomal acid glucosylceramidase Homo sapiens 1.56 5.2 US Patent 10.7270/Q2CV4GG7 aid1801319 US9056847 Aerts, JM; Overkleeft, HS ACADEMISCH MEDISCH CENTRUM BIJ UNIVERSITEIT VAN AMSTERDAM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60418&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3229223 14723317 ZINC26438884 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228401 OCC1C(O)C(O)C(O)c2nccn12 InChI=1S/C8H12N2O4/c11-3-4-5(12)6(13)7(14)8-9-1-2-10(4)8/h1-2,4-7,11-14H,3H2 RZRDQZQPTISYKY-UHFFFAOYSA-N 108215 5-(hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2- a]pyridine-6,7,8-triol (Compound 1) Lysosomal acid glucosylceramidase Homo sapiens 79.2 7 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108215&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search MVL 4AYQ,6FAR,6F90,2VMF,3D4Y,4RE2,2WZS,6F92,6RQK,4CD8,4CD5,6T7G,7NSN 69323450 186525085 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228402 OCC1C(O)C(O)C(O)c2nc(CCc3ccccc3)cn12 InChI=1S/C16H20N2O4/c19-9-12-13(20)14(21)15(22)16-17-11(8-18(12)16)7-6-10-4-2-1-3-5-10/h1-5,8,12-15,19-22H,6-7,9H2 MLRMIFDEZCZOAE-UHFFFAOYSA-N 108216 5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- imidazo[1,2-a]pyridine-6,7,8-triol (Compound 2) Lysosomal acid glucosylceramidase Homo sapiens 2.04 7 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108216&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 72796957 186525086 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228403 CC(C)(C)CCc1cn2C(CO)C(O)C(O)C(O)c2n1 InChI=1S/C14H24N2O4/c1-14(2,3)5-4-8-6-16-9(7-17)10(18)11(19)12(20)13(16)15-8/h6,9-12,17-20H,4-5,7H2,1-3H3 CFJPBGQYMKXSJT-UHFFFAOYSA-N 108217 2-(3,3-dimethylbutyl)-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 3) Lysosomal acid glucosylceramidase Homo sapiens 4.26 7 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108217&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67206574 186525087 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228404 CCCCCCCCc1cn2C(CO)C(O)C(O)C(O)c2n1 InChI=1S/C16H28N2O4/c1-2-3-4-5-6-7-8-11-9-18-12(10-19)13(20)14(21)15(22)16(18)17-11/h9,12-15,19-22H,2-8,10H2,1H3 OMVDIWMZQBJVFN-UHFFFAOYSA-N 108218 5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2- a]pyridine-6,7,8-triol (Compound 4) Lysosomal acid glucosylceramidase Homo sapiens 5.05 7 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108218&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 72974915 186525088 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228405 Cc1ccc(CCCc2cn3C(CO)C(O)C(O)C(O)c3n2)cc1 InChI=1S/C18H24N2O4/c1-11-5-7-12(8-6-11)3-2-4-13-9-20-14(10-21)15(22)16(23)17(24)18(20)19-13/h5-9,14-17,21-24H,2-4,10H2,1H3 FETSBCRHESSCQO-UHFFFAOYSA-N 108219 5-(hydroxymethyl)-2-[3-(4-methylphenyl)propyl]- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 5) Lysosomal acid glucosylceramidase Homo sapiens 4.73 7 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108219&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982385 186525089 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228406 COc1ccc(CCCc2cn3C(CO)C(O)C(O)C(O)c3n2)cc1 InChI=1S/C18H24N2O5/c1-25-13-7-5-11(6-8-13)3-2-4-12-9-20-14(10-21)15(22)16(23)17(24)18(20)19-12/h5-9,14-17,21-24H,2-4,10H2,1H3 CEEPDUGFKXBMCP-UHFFFAOYSA-N 108220 5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 6) Lysosomal acid glucosylceramidase Homo sapiens 3.62 7 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108220&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982386 186525090 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228407 OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(cc3)-c3ccccc3)cn12 InChI=1S/C23H26N2O4/c26-14-19-20(27)21(28)22(29)23-24-18(13-25(19)23)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h1-3,6-7,9-13,19-22,26-29H,4-5,8,14H2 JYUBGYMPVKAJEH-UHFFFAOYSA-N 108221 5-(hydroxymethyl)-2-[3-(4-phenylphenyl)propyl]- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 7) Lysosomal acid glucosylceramidase Homo sapiens 5.11 7 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108221&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982387 186525091 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228408 OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(cc3)C3CCCCC3)cn12 InChI=1S/C23H32N2O4/c26-14-19-20(27)21(28)22(29)23-24-18(13-25(19)23)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h9-13,16,19-22,26-29H,1-8,14H2 KACLQPKKHWDLNL-UHFFFAOYSA-N 108222 2-[3-(4-cyclohexylphenyl)propyl]-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 8) Lysosomal acid glucosylceramidase Homo sapiens 7.80 7 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108222&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982388 186525092 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228409 OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(F)cc3)cn12 InChI=1S/C17H21FN2O4/c18-11-6-4-10(5-7-11)2-1-3-12-8-20-13(9-21)14(22)15(23)16(24)17(20)19-12/h4-8,13-16,21-24H,1-3,9H2 GTFOIXYCSJUOKQ-UHFFFAOYSA-N 108223 2-[3-(4-fluorophenyl)propyl]-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 9) Lysosomal acid glucosylceramidase Homo sapiens 4.75 7 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108223&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982389 186525093 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228410 OCC1C(O)C(O)C(O)c2nc(CCCC(=O)Nc3ccccc3)cn12 InChI=1S/C18H23N3O5/c22-10-13-15(24)16(25)17(26)18-20-12(9-21(13)18)7-4-8-14(23)19-11-5-2-1-3-6-11/h1-3,5-6,9,13,15-17,22,24-26H,4,7-8,10H2,(H,19,23) NFCRLBOYIVLLLQ-UHFFFAOYSA-N 108224 N-phenyl-4-[6,7,8-trihydroxy-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridin-2-yl]butanamide (Compound 10) Lysosomal acid glucosylceramidase Homo sapiens 7.67 7 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108224&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982390 186525094 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228411 CC(C)(CCCc1cn2C(CO)C(O)C(O)C(O)c2n1)C(=O)Nc1ccccc1 InChI=1S/C21H29N3O5/c1-21(2,20(29)23-13-7-4-3-5-8-13)10-6-9-14-11-24-15(12-25)16(26)17(27)18(28)19(24)22-14/h3-5,7-8,11,15-18,25-28H,6,9-10,12H2,1-2H3,(H,23,29) BJVGBJYNQFORDI-UHFFFAOYSA-N 108225 2,2-dimethyl-N-phenyl-5-[6,7,8-trihydroxy-5- (hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyridin-2- yl]pentanamide (Compound 11) Lysosomal acid glucosylceramidase Homo sapiens 11.5 7 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108225&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982391 186525095 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228412 CCCCCCCCCN1CC(O)C(O)C(O)C1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3 FTSCEGKYKXESFF-UHFFFAOYSA-N 50156357 2-Hydroxymethyl-1-nonyl-piperidine-3,4,5-triol::CHEMBL187158::NN-DNJ Lysosomal acid glucosylceramidase Homo sapiens 668 7 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156357&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 3272526 104043509 CHEMBL187158 ZINC36338459 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228413 OCC1C(O)C(O)C(O)c2nccn12 InChI=1S/C8H12N2O4/c11-3-4-5(12)6(13)7(14)8-9-1-2-10(4)8/h1-2,4-7,11-14H,3H2 RZRDQZQPTISYKY-UHFFFAOYSA-N 108215 5-(hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2- a]pyridine-6,7,8-triol (Compound 1) Lysosomal acid glucosylceramidase Homo sapiens 91.6 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108215&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search MVL 4AYQ,6FAR,6F90,2VMF,3D4Y,4RE2,2WZS,6F92,6RQK,4CD8,4CD5,6T7G,7NSN 69323450 186525085 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228414 OCC1C(O)C(O)C(O)c2nc(CCc3ccccc3)cn12 InChI=1S/C16H20N2O4/c19-9-12-13(20)14(21)15(22)16-17-11(8-18(12)16)7-6-10-4-2-1-3-5-10/h1-5,8,12-15,19-22H,6-7,9H2 MLRMIFDEZCZOAE-UHFFFAOYSA-N 108216 5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- imidazo[1,2-a]pyridine-6,7,8-triol (Compound 2) Lysosomal acid glucosylceramidase Homo sapiens 3.71 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108216&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 72796957 186525086 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228415 CC(C)(C)CCc1cn2C(CO)C(O)C(O)C(O)c2n1 InChI=1S/C14H24N2O4/c1-14(2,3)5-4-8-6-16-9(7-17)10(18)11(19)12(20)13(16)15-8/h6,9-12,17-20H,4-5,7H2,1-3H3 CFJPBGQYMKXSJT-UHFFFAOYSA-N 108217 2-(3,3-dimethylbutyl)-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 3) Lysosomal acid glucosylceramidase Homo sapiens 5.34 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108217&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67206574 186525087 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228416 CCCCCCCCc1cn2C(CO)C(O)C(O)C(O)c2n1 InChI=1S/C16H28N2O4/c1-2-3-4-5-6-7-8-11-9-18-12(10-19)13(20)14(21)15(22)16(18)17-11/h9,12-15,19-22H,2-8,10H2,1H3 OMVDIWMZQBJVFN-UHFFFAOYSA-N 108218 5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2- a]pyridine-6,7,8-triol (Compound 4) Lysosomal acid glucosylceramidase Homo sapiens 8.39 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108218&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 72974915 186525088 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228417 Cc1ccc(CCCc2cn3C(CO)C(O)C(O)C(O)c3n2)cc1 InChI=1S/C18H24N2O4/c1-11-5-7-12(8-6-11)3-2-4-13-9-20-14(10-21)15(22)16(23)17(24)18(20)19-13/h5-9,14-17,21-24H,2-4,10H2,1H3 FETSBCRHESSCQO-UHFFFAOYSA-N 108219 5-(hydroxymethyl)-2-[3-(4-methylphenyl)propyl]- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 5) Lysosomal acid glucosylceramidase Homo sapiens 5.44 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108219&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982385 186525089 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228418 COc1ccc(CCCc2cn3C(CO)C(O)C(O)C(O)c3n2)cc1 InChI=1S/C18H24N2O5/c1-25-13-7-5-11(6-8-13)3-2-4-12-9-20-14(10-21)15(22)16(23)17(24)18(20)19-12/h5-9,14-17,21-24H,2-4,10H2,1H3 CEEPDUGFKXBMCP-UHFFFAOYSA-N 108220 5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 6) Lysosomal acid glucosylceramidase Homo sapiens 2.97 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108220&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982386 186525090 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228419 OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(cc3)-c3ccccc3)cn12 InChI=1S/C23H26N2O4/c26-14-19-20(27)21(28)22(29)23-24-18(13-25(19)23)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h1-3,6-7,9-13,19-22,26-29H,4-5,8,14H2 JYUBGYMPVKAJEH-UHFFFAOYSA-N 108221 5-(hydroxymethyl)-2-[3-(4-phenylphenyl)propyl]- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 7) Lysosomal acid glucosylceramidase Homo sapiens 5.27 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108221&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982387 186525091 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228420 OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(cc3)C3CCCCC3)cn12 InChI=1S/C23H32N2O4/c26-14-19-20(27)21(28)22(29)23-24-18(13-25(19)23)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h9-13,16,19-22,26-29H,1-8,14H2 KACLQPKKHWDLNL-UHFFFAOYSA-N 108222 2-[3-(4-cyclohexylphenyl)propyl]-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 8) Lysosomal acid glucosylceramidase Homo sapiens 8.42 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108222&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982388 186525092 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228421 OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(F)cc3)cn12 InChI=1S/C17H21FN2O4/c18-11-6-4-10(5-7-11)2-1-3-12-8-20-13(9-21)14(22)15(23)16(24)17(20)19-12/h4-8,13-16,21-24H,1-3,9H2 GTFOIXYCSJUOKQ-UHFFFAOYSA-N 108223 2-[3-(4-fluorophenyl)propyl]-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 9) Lysosomal acid glucosylceramidase Homo sapiens 6.23 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108223&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982389 186525093 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228422 OCC1C(O)C(O)C(O)c2nc(CCCC(=O)Nc3ccccc3)cn12 InChI=1S/C18H23N3O5/c22-10-13-15(24)16(25)17(26)18-20-12(9-21(13)18)7-4-8-14(23)19-11-5-2-1-3-6-11/h1-3,5-6,9,13,15-17,22,24-26H,4,7-8,10H2,(H,19,23) NFCRLBOYIVLLLQ-UHFFFAOYSA-N 108224 N-phenyl-4-[6,7,8-trihydroxy-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridin-2-yl]butanamide (Compound 10) Lysosomal acid glucosylceramidase Homo sapiens 6.96 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108224&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982390 186525094 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228423 CC(C)(CCCc1cn2C(CO)C(O)C(O)C(O)c2n1)C(=O)Nc1ccccc1 InChI=1S/C21H29N3O5/c1-21(2,20(29)23-13-7-4-3-5-8-13)10-6-9-14-11-24-15(12-25)16(26)17(27)18(28)19(24)22-14/h3-5,7-8,11,15-18,25-28H,6,9-10,12H2,1-2H3,(H,23,29) BJVGBJYNQFORDI-UHFFFAOYSA-N 108225 2,2-dimethyl-N-phenyl-5-[6,7,8-trihydroxy-5- (hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyridin-2- yl]pentanamide (Compound 11) Lysosomal acid glucosylceramidase Homo sapiens 12.0 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108225&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982391 186525095 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228424 CCCCCCCCCN1CC(O)C(O)C(O)C1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3 FTSCEGKYKXESFF-UHFFFAOYSA-N 50156357 2-Hydroxymethyl-1-nonyl-piperidine-3,4,5-triol::CHEMBL187158::NN-DNJ Lysosomal acid glucosylceramidase Homo sapiens 979 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800217 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156357&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 3272526 104043509 CHEMBL187158 ZINC36338459 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228425 OCC1C(O)C(O)C(O)c2nccn12 InChI=1S/C8H12N2O4/c11-3-4-5(12)6(13)7(14)8-9-1-2-10(4)8/h1-2,4-7,11-14H,3H2 RZRDQZQPTISYKY-UHFFFAOYSA-N 108215 5-(hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2- a]pyridine-6,7,8-triol (Compound 1) Lysosomal acid glucosylceramidase Homo sapiens 33.1 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800219 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108215&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search MVL 4AYQ,6FAR,6F90,2VMF,3D4Y,4RE2,2WZS,6F92,6RQK,4CD8,4CD5,6T7G,7NSN 69323450 186525085 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228426 OCC1C(O)C(O)C(O)c2nc(CCc3ccccc3)cn12 InChI=1S/C16H20N2O4/c19-9-12-13(20)14(21)15(22)16-17-11(8-18(12)16)7-6-10-4-2-1-3-5-10/h1-5,8,12-15,19-22H,6-7,9H2 MLRMIFDEZCZOAE-UHFFFAOYSA-N 108216 5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- imidazo[1,2-a]pyridine-6,7,8-triol (Compound 2) Lysosomal acid glucosylceramidase Homo sapiens 3.19 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800219 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108216&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 72796957 186525086 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228427 CC(C)(C)CCc1cn2C(CO)C(O)C(O)C(O)c2n1 InChI=1S/C14H24N2O4/c1-14(2,3)5-4-8-6-16-9(7-17)10(18)11(19)12(20)13(16)15-8/h6,9-12,17-20H,4-5,7H2,1-3H3 CFJPBGQYMKXSJT-UHFFFAOYSA-N 108217 2-(3,3-dimethylbutyl)-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 3) Lysosomal acid glucosylceramidase Homo sapiens 5.34 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800219 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108217&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67206574 186525087 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228428 CCCCCCCCc1cn2C(CO)C(O)C(O)C(O)c2n1 InChI=1S/C16H28N2O4/c1-2-3-4-5-6-7-8-11-9-18-12(10-19)13(20)14(21)15(22)16(18)17-11/h9,12-15,19-22H,2-8,10H2,1H3 OMVDIWMZQBJVFN-UHFFFAOYSA-N 108218 5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2- a]pyridine-6,7,8-triol (Compound 4) Lysosomal acid glucosylceramidase Homo sapiens 5.38 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800219 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108218&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 72974915 186525088 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228429 Cc1ccc(CCCc2cn3C(CO)C(O)C(O)C(O)c3n2)cc1 InChI=1S/C18H24N2O4/c1-11-5-7-12(8-6-11)3-2-4-13-9-20-14(10-21)15(22)16(23)17(24)18(20)19-13/h5-9,14-17,21-24H,2-4,10H2,1H3 FETSBCRHESSCQO-UHFFFAOYSA-N 108219 5-(hydroxymethyl)-2-[3-(4-methylphenyl)propyl]- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 5) Lysosomal acid glucosylceramidase Homo sapiens 1.46 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800219 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108219&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982385 186525089 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228430 COc1ccc(CCCc2cn3C(CO)C(O)C(O)C(O)c3n2)cc1 InChI=1S/C18H24N2O5/c1-25-13-7-5-11(6-8-13)3-2-4-12-9-20-14(10-21)15(22)16(23)17(24)18(20)19-12/h5-9,14-17,21-24H,2-4,10H2,1H3 CEEPDUGFKXBMCP-UHFFFAOYSA-N 108220 5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 6) Lysosomal acid glucosylceramidase Homo sapiens 1.17 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800219 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108220&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982386 186525090 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228431 OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(cc3)-c3ccccc3)cn12 InChI=1S/C23H26N2O4/c26-14-19-20(27)21(28)22(29)23-24-18(13-25(19)23)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h1-3,6-7,9-13,19-22,26-29H,4-5,8,14H2 JYUBGYMPVKAJEH-UHFFFAOYSA-N 108221 5-(hydroxymethyl)-2-[3-(4-phenylphenyl)propyl]- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 7) Lysosomal acid glucosylceramidase Homo sapiens 3.62 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800219 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108221&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982387 186525091 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228432 OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(cc3)C3CCCCC3)cn12 InChI=1S/C23H32N2O4/c26-14-19-20(27)21(28)22(29)23-24-18(13-25(19)23)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h9-13,16,19-22,26-29H,1-8,14H2 KACLQPKKHWDLNL-UHFFFAOYSA-N 108222 2-[3-(4-cyclohexylphenyl)propyl]-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 8) Lysosomal acid glucosylceramidase Homo sapiens 1.93 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800219 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108222&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982388 186525092 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228433 OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(F)cc3)cn12 InChI=1S/C17H21FN2O4/c18-11-6-4-10(5-7-11)2-1-3-12-8-20-13(9-21)14(22)15(23)16(24)17(20)19-12/h4-8,13-16,21-24H,1-3,9H2 GTFOIXYCSJUOKQ-UHFFFAOYSA-N 108223 2-[3-(4-fluorophenyl)propyl]-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 9) Lysosomal acid glucosylceramidase Homo sapiens 3.48 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800219 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108223&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982389 186525093 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228434 OCC1C(O)C(O)C(O)c2nc(CCCC(=O)Nc3ccccc3)cn12 InChI=1S/C18H23N3O5/c22-10-13-15(24)16(25)17(26)18-20-12(9-21(13)18)7-4-8-14(23)19-11-5-2-1-3-6-11/h1-3,5-6,9,13,15-17,22,24-26H,4,7-8,10H2,(H,19,23) NFCRLBOYIVLLLQ-UHFFFAOYSA-N 108224 N-phenyl-4-[6,7,8-trihydroxy-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridin-2-yl]butanamide (Compound 10) Lysosomal acid glucosylceramidase Homo sapiens 4.18 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800219 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108224&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982390 186525094 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228435 CC(C)(CCCc1cn2C(CO)C(O)C(O)C(O)c2n1)C(=O)Nc1ccccc1 InChI=1S/C21H29N3O5/c1-21(2,20(29)23-13-7-4-3-5-8-13)10-6-9-14-11-24-15(12-25)16(26)17(27)18(28)19(24)22-14/h3-5,7-8,11,15-18,25-28H,6,9-10,12H2,1-2H3,(H,23,29) BJVGBJYNQFORDI-UHFFFAOYSA-N 108225 2,2-dimethyl-N-phenyl-5-[6,7,8-trihydroxy-5- (hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyridin-2- yl]pentanamide (Compound 11) Lysosomal acid glucosylceramidase Homo sapiens 18.9 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800219 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108225&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 74982391 186525095 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228436 CCCCCCCCCN1CC(O)C(O)C(O)C1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3 FTSCEGKYKXESFF-UHFFFAOYSA-N 50156357 2-Hydroxymethyl-1-nonyl-piperidine-3,4,5-triol::CHEMBL187158::NN-DNJ Lysosomal acid glucosylceramidase Homo sapiens 488 5.2 Curated from the literature by BindingDB 10.1002/cbic.201300197 10.7270/Q2NS0SHP 23775891 aid1800219 Li, Z; Li, T; Dai, S; Xie, X; Ma, X; Zhao, W; Zhang, W; Li, J; Wang, PG Nankai University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156357&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 3272526 104043509 CHEMBL187158 ZINC36338459 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228724 CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C7H14FNO2/c1-4(8)5-2-9-3-6(10)7(5)11/h4-7,9-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1 ADGVYUWMIQUOME-UVSCYPECSA-N 108418 US8604206, 13::US8604206, 14 Lysosomal acid glucosylceramidase Homo sapiens 49.8 94.6 5.2 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108418&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51050004 186525288 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228725 CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1 YEZMDJVWNQIFDP-UVSCYPECSA-N 108419 US8604206, 10::US8604206, 9 Lysosomal acid glucosylceramidase Homo sapiens 44 107 5.2 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108419&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51356185 186525289 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228726 CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1 YEZMDJVWNQIFDP-UVSCYPECSA-N 108419 US8604206, 10::US8604206, 9 Lysosomal acid glucosylceramidase Homo sapiens 142 343 5.2 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108419&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51356185 186525289 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228727 CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C7H14FNO2/c1-4(8)5-2-9-3-6(10)7(5)11/h4-7,9-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1 ADGVYUWMIQUOME-UVSCYPECSA-N 108418 US8604206, 13::US8604206, 14 Lysosomal acid glucosylceramidase Homo sapiens 16 38 5.2 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108418&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51050004 186525288 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228728 O[C@@H]1CNC[C@H](Cc2ccccc2)[C@H]1O InChI=1S/C12H17NO2/c14-11-8-13-7-10(12(11)15)6-9-4-2-1-3-5-9/h1-5,10-15H,6-8H2/t10-,11+,12+/m0/s1 WUEAMJOBFYKMLP-QJPTWQEYSA-N 108422 US8604206, (3R,4R,5S)-5-benzyl-piperidine-3,4-diol Lysosomal acid glucosylceramidase Homo sapiens 273 659 5.2 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108422&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51356184 186525292 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228729 O[C@@H]([C@H]1CNC[C@@H](O)[C@@H]1O)c1ccccc1 InChI=1S/C12H17NO3/c14-10-7-13-6-9(12(10)16)11(15)8-4-2-1-3-5-8/h1-5,9-16H,6-7H2/t9-,10-,11-,12-/m1/s1 AQILKYRWFPWHAA-DDHJBXDOSA-N 108423 US8604206, (3R,4R,5R)-5((S)-hydroxy(phenyl)methyl)-piperidine-3,4-diol Lysosomal acid glucosylceramidase Homo sapiens 1.36e+3 3290 5.2 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108423&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 71073983 186525293 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228730 CC(C)(O)[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C8H17NO3/c1-8(2,12)5-3-9-4-6(10)7(5)11/h5-7,9-12H,3-4H2,1-2H3/t5-,6+,7+/m0/s1 PVGDVTWSNAIFDH-RRKCRQDMSA-N 108424 US8604206, (3R,4R,5S)-5(2-hydroxypropan-2-yl)piperidine-3,4-diol Lysosomal acid glucosylceramidase Homo sapiens 97 234 5.2 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108424&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51356190 186525294 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228731 O[C@@H]1CNC[C@H](C(F)F)[C@H]1O InChI=1S/C6H11F2NO2/c7-6(8)3-1-9-2-4(10)5(3)11/h3-6,9-11H,1-2H2/t3-,4+,5+/m0/s1 QSMPJEGWIQSKCL-VPENINKCSA-N 108417 US8604206, 6 Lysosomal acid glucosylceramidase Homo sapiens 3.06 5.8 7 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108417&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51049977 186525287 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228732 CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C7H14FNO2/c1-4(8)5-2-9-3-6(10)7(5)11/h4-7,9-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1 ADGVYUWMIQUOME-UVSCYPECSA-N 108418 US8604206, 13::US8604206, 14 Lysosomal acid glucosylceramidase Homo sapiens 0.9 17.1 7 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108418&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51050004 186525288 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228733 CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1 YEZMDJVWNQIFDP-UVSCYPECSA-N 108419 US8604206, 10::US8604206, 9 Lysosomal acid glucosylceramidase Homo sapiens 10 20 7 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108419&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51356185 186525289 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228734 CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1 YEZMDJVWNQIFDP-UVSCYPECSA-N 108419 US8604206, 10::US8604206, 9 Lysosomal acid glucosylceramidase Homo sapiens 35 66 7 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108419&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51356185 186525289 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228735 CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C7H14FNO2/c1-4(8)5-2-9-3-6(10)7(5)11/h4-7,9-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1 ADGVYUWMIQUOME-UVSCYPECSA-N 108418 US8604206, 13::US8604206, 14 Lysosomal acid glucosylceramidase Homo sapiens 4 7 7 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108418&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51050004 186525288 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228736 O[C@@H]1CNC[C@H](Cc2ccccc2)[C@H]1O InChI=1S/C12H17NO2/c14-11-8-13-7-10(12(11)15)6-9-4-2-1-3-5-9/h1-5,10-15H,6-8H2/t10-,11+,12+/m0/s1 WUEAMJOBFYKMLP-QJPTWQEYSA-N 108422 US8604206, (3R,4R,5S)-5-benzyl-piperidine-3,4-diol Lysosomal acid glucosylceramidase Homo sapiens 67 127 7 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108422&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51356184 186525292 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228737 O[C@@H]([C@H]1CNC[C@@H](O)[C@@H]1O)c1ccccc1 InChI=1S/C12H17NO3/c14-10-7-13-6-9(12(10)16)11(15)8-4-2-1-3-5-8/h1-5,9-16H,6-7H2/t9-,10-,11-,12-/m1/s1 AQILKYRWFPWHAA-DDHJBXDOSA-N 108423 US8604206, (3R,4R,5R)-5((S)-hydroxy(phenyl)methyl)-piperidine-3,4-diol Lysosomal acid glucosylceramidase Homo sapiens 8.9 17 7 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108423&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 71073983 186525293 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228738 CC(C)(O)[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C8H17NO3/c1-8(2,12)5-3-9-4-6(10)7(5)11/h5-7,9-12H,3-4H2,1-2H3/t5-,6+,7+/m0/s1 PVGDVTWSNAIFDH-RRKCRQDMSA-N 108424 US8604206, (3R,4R,5S)-5(2-hydroxypropan-2-yl)piperidine-3,4-diol Lysosomal acid glucosylceramidase Homo sapiens 15 29 7 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108424&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51356190 186525294 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 228739 O[C@@H]1CNC[C@H](C(F)F)[C@H]1O InChI=1S/C6H11F2NO2/c7-6(8)3-1-9-2-4(10)5(3)11/h3-6,9-11H,1-2H2/t3-,4+,5+/m0/s1 QSMPJEGWIQSKCL-VPENINKCSA-N 108417 US8604206, 6 Lysosomal acid glucosylceramidase Homo sapiens 13.6 25.9 5.2 US Patent 10.7270/Q2MS3RDR aid1800226 US8604206 Boyd, R; Lee, G; Rybczynski, P Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108417&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51049977 186525287 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 305514 O[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/m0/s1 ZHMWOVGZCINIHW-FTYOSCRSSA-N 50078114 (1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,3,4,5-tetraol::CHEMBL291020::Conduritol B Epoxide::Conduritol B Epoxide, 2::US9056847, Conduritol B- epoxide Lysosomal acid glucosylceramidase Homo sapiens 7726 12000 5.2 US Patent 10.7270/Q2CV4GG7 aid1801319 US9056847 Aerts, JM; Overkleeft, HS ACADEMISCH MEDISCH CENTRUM BIJ UNIVERSITEIT VAN AMSTERDAM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078114&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 119054 103970749 67235 CHEMBL291020 ZINC17995199 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 305515 O[C@H]1[C@@H]2O[C@@H]2[C@H](CN=[N+]=[N-])[C@@H](O)[C@@H]1O InChI=1S/C7H11N3O4/c8-10-9-1-2-3(11)4(12)5(13)7-6(2)14-7/h2-7,11-13H,1H2/t2-,3-,4+,5-,6-,7+/m1/s1 ZESQJCJZDKDCAM-GEGSFZHJSA-N 36513 CID46912128::KY170, 4::US9056847, Azido-cyclophellitol Lysosomal acid glucosylceramidase Homo sapiens 83 150 5.2 US Patent 10.7270/Q2CV4GG7 aid1801319 US9056847 Aerts, JM; Overkleeft, HS ACADEMISCH MEDISCH CENTRUM BIJ UNIVERSITEIT VAN AMSTERDAM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36513&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46912128 117644099 ZINC34116219 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 305516 CC1=CC(C)=[N+]2C1=C(CCCCc1cn(C[C@H]3[C@H]4O[C@H]4[C@H](O)[C@@H](O)[C@@H]3O)nn1)c1c(C)cc(C)n1[B-]2(F)F InChI=1S/C26H34BF2N5O4/c1-13-9-15(3)33-20(13)18(21-14(2)10-16(4)34(21)27(33,28)29)8-6-5-7-17-11-32(31-30-17)12-19-22(35)23(36)24(37)26-25(19)38-26/h9-11,19,22-26,35-37H,5-8,12H2,1-4H3/t19-,22-,23+,24-,25-,26+/m1/s1 IZGBBUJVVVRRFK-DQTYAKANSA-N 162702 US9056847, Fluorophore 1-cyclophellitol Lysosomal acid glucosylceramidase Homo sapiens 0.95 2 5.2 US Patent 10.7270/Q2CV4GG7 aid1801319 US9056847 Aerts, JM; Overkleeft, HS ACADEMISCH MEDISCH CENTRUM BIJ UNIVERSITEIT VAN AMSTERDAM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=162702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=162702&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46912122 310304642 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415409 CCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1 InChI=1S/C9H19NO3/c1-2-3-10-4-7(6-11)9(13)8(12)5-10/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1 VURPXSSEBVGWQX-IWSPIJDZSA-N 238197 US9402837, 1 Lysosomal acid glucosylceramidase Homo sapiens 14840 35810 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238197&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67509469 340131597 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415410 CCCCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1 InChI=1S/C11H23NO3/c1-2-3-4-5-12-6-9(8-13)11(15)10(14)7-12/h9-11,13-15H,2-8H2,1H3/t9-,10-,11-/m1/s1 HQRWMZVXYSGFQJ-GMTAPVOTSA-N 238198 US9402837, 2 Lysosomal acid glucosylceramidase Homo sapiens 406060 979900 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238198&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67508445 340131598 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415411 CCCCCCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1 InChI=1S/C13H27NO3/c1-2-3-4-5-6-7-14-8-11(10-15)13(17)12(16)9-14/h11-13,15-17H,2-10H2,1H3/t11-,12-,13-/m1/s1 FQBCZWBBRFJEFK-JHJVBQTASA-N 238199 US9402837, 3 Lysosomal acid glucosylceramidase Homo sapiens 17280 41700 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238199&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67509603 340131599 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415412 CC(C)=CCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1 InChI=1S/C11H21NO3/c1-8(2)3-4-12-5-9(7-13)11(15)10(14)6-12/h3,9-11,13-15H,4-7H2,1-2H3/t9-,10-,11-/m1/s1 PQAUOIYEPRBRRD-GMTAPVOTSA-N 238200 US9402837, 4 Lysosomal acid glucosylceramidase Homo sapiens 1660 4000 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238200&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67509498 340131600 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415413 COCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1 InChI=1S/C9H19NO4/c1-14-3-2-10-4-7(6-11)9(13)8(12)5-10/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1 ZZQPMCUSRPWYPE-IWSPIJDZSA-N 238201 US9402837, 5 Lysosomal acid glucosylceramidase Homo sapiens 2480 5990 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238201&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67510210 340131601 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415414 OC[C@H]1CN(Cc2ccccc2)C[C@@H](O)[C@@H]1O InChI=1S/C13H19NO3/c15-9-11-7-14(8-12(16)13(11)17)6-10-4-2-1-3-5-10/h1-5,11-13,15-17H,6-9H2/t11-,12-,13-/m1/s1 SGPVIQCAOCSXHN-JHJVBQTASA-N 238202 US9402837, 6 Lysosomal acid glucosylceramidase Homo sapiens 82990 200270 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238202&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 54304602 340131602 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415415 Cc1ccccc1CN1C[C@@H](O)[C@H](O)[C@@H](CO)C1 InChI=1S/C14H21NO3/c1-10-4-2-3-5-11(10)6-15-7-12(9-16)14(18)13(17)8-15/h2-5,12-14,16-18H,6-9H2,1H3/t12-,13-,14-/m1/s1 FBYMXLLBYHENBK-MGPQQGTHSA-N 238203 US9402837, 7 Lysosomal acid glucosylceramidase Homo sapiens 28790 69470 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238203&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67508866 340131603 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415416 Cc1cccc(CN2C[C@@H](O)[C@H](O)[C@@H](CO)C2)c1 InChI=1S/C14H21NO3/c1-10-3-2-4-11(5-10)6-15-7-12(9-16)14(18)13(17)8-15/h2-5,12-14,16-18H,6-9H2,1H3/t12-,13-,14-/m1/s1 KKYOXNWQRVZXFR-MGPQQGTHSA-N 238204 US9402837, 8 Lysosomal acid glucosylceramidase Homo sapiens 5260 12700 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238204&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67510038 340131604 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415417 Cc1ccc(CN2C[C@@H](O)[C@H](O)[C@@H](CO)C2)cc1 InChI=1S/C14H21NO3/c1-10-2-4-11(5-3-10)6-15-7-12(9-16)14(18)13(17)8-15/h2-5,12-14,16-18H,6-9H2,1H3/t12-,13-,14-/m1/s1 RYIRWESPUZPXRZ-MGPQQGTHSA-N 238205 US9402837, 9 Lysosomal acid glucosylceramidase Homo sapiens 53720 129630 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238205&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67509108 340131605 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415418 OC[C@H]1CN(Cc2ccc(F)cc2)C[C@@H](O)[C@@H]1O InChI=1S/C13H18FNO3/c14-11-3-1-9(2-4-11)5-15-6-10(8-16)13(18)12(17)7-15/h1-4,10,12-13,16-18H,5-8H2/t10-,12-,13-/m1/s1 IJAGUXHRYPNJAM-RAIGVLPGSA-N 238206 US9402837, 10 Lysosomal acid glucosylceramidase Homo sapiens 111800 269800 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238206&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67510634 340131606 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415419 Nc1ccc(CN2C[C@@H](O)[C@H](O)[C@@H](CO)C2)cc1 InChI=1S/C13H20N2O3/c14-11-3-1-9(2-4-11)5-15-6-10(8-16)13(18)12(17)7-15/h1-4,10,12-13,16-18H,5-8,14H2/t10-,12-,13-/m1/s1 LVUCVLGHEJMJMX-RAIGVLPGSA-N 238207 US9402837, 12 Lysosomal acid glucosylceramidase Homo sapiens 3880 9360 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238207&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67509514 340131607 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415420 OC[C@H]1CN(CCc2ccccc2)C[C@@H](O)[C@@H]1O InChI=1S/C14H21NO3/c16-10-12-8-15(9-13(17)14(12)18)7-6-11-4-2-1-3-5-11/h1-5,12-14,16-18H,6-10H2/t12-,13-,14-/m1/s1 YHOKUSQHIOHUDJ-MGPQQGTHSA-N 238208 US9402837, 13 Lysosomal acid glucosylceramidase Homo sapiens 3110 7500 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238208&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67510856 340131608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415421 OC[C@H]1CN(CC2CCOCC2)C[C@@H](O)[C@@H]1O InChI=1S/C12H23NO4/c14-8-10-6-13(7-11(15)12(10)16)5-9-1-3-17-4-2-9/h9-12,14-16H,1-8H2/t10-,11-,12-/m1/s1 CQVRHCPRHKKMJS-IJLUTSLNSA-N 238209 US9402837, 15 Lysosomal acid glucosylceramidase Homo sapiens 20390 49220 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238209&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67509903 340131609 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415422 OC[C@H]1CN(CC2CCNCC2)C[C@@H](O)[C@@H]1O InChI=1S/C12H24N2O3/c15-8-10-6-14(7-11(16)12(10)17)5-9-1-3-13-4-2-9/h9-13,15-17H,1-8H2/t10-,11-,12-/m1/s1 RYBXNLJWPSALOR-IJLUTSLNSA-N 238210 US9402837, 16 Lysosomal acid glucosylceramidase Homo sapiens 440 1070 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238210&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67509922 340131610 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415423 OC[C@H]1CN(Cc2ccco2)C[C@@H](O)[C@@H]1O InChI=1S/C11H17NO4/c13-7-8-4-12(6-10(14)11(8)15)5-9-2-1-3-16-9/h1-3,8,10-11,13-15H,4-7H2/t8-,10-,11-/m1/s1 AYTXWKIAYUJDTC-FBIMIBRVSA-N 238211 US9402837, 17 Lysosomal acid glucosylceramidase Homo sapiens 116390 280070 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238211&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67509777 340131611 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415424 OC[C@H]1CN(Cc2cccs2)C[C@@H](O)[C@@H]1O InChI=1S/C11H17NO3S/c13-7-8-4-12(6-10(14)11(8)15)5-9-2-1-3-16-9/h1-3,8,10-11,13-15H,4-7H2/t8-,10-,11-/m1/s1 KCZNVTQEXHDTJB-FBIMIBRVSA-N 238216 US9402837, 18 Lysosomal acid glucosylceramidase Homo sapiens 11420 27550 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238216&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67510329 340131616 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415425 OC[C@H]1CN(Cc2ccncc2)C[C@@H](O)[C@@H]1O InChI=1S/C12H18N2O3/c15-8-10-6-14(7-11(16)12(10)17)5-9-1-3-13-4-2-9/h1-4,10-12,15-17H,5-8H2/t10-,11-,12-/m1/s1 HEUKMGNKIWGRQK-IJLUTSLNSA-N 238212 US9402837, 19 Lysosomal acid glucosylceramidase Homo sapiens 8020 19350 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238212&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67508833 340131612 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415426 OC[C@H]1CN(CC2CCCC2)C[C@@H](O)[C@@H]1O InChI=1S/C12H23NO3/c14-8-10-6-13(7-11(15)12(10)16)5-9-3-1-2-4-9/h9-12,14-16H,1-8H2/t10-,11-,12-/m1/s1 GTLQXRMLXLQXBJ-IJLUTSLNSA-N 238213 US9402837, 23 Lysosomal acid glucosylceramidase Homo sapiens 6480 15630 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238213&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67510415 340131613 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415427 CC(C)CCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1 InChI=1S/C12H25NO3/c1-9(2)4-3-5-13-6-10(8-14)12(16)11(15)7-13/h9-12,14-16H,3-8H2,1-2H3/t10-,11-,12-/m1/s1 BMZCRDKQUUDUMG-IJLUTSLNSA-N 238214 US9402837, 24 Lysosomal acid glucosylceramidase Homo sapiens 880 2130 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238214&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67509458 340131614 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 415428 OC[C@H]1CN(Cc2ccc(cc2)[N+]([O-])=O)C[C@@H](O)[C@@H]1O InChI=1S/C13H18N2O5/c16-8-10-6-14(7-12(17)13(10)18)5-9-1-3-11(4-2-9)15(19)20/h1-4,10,12-13,16-18H,5-8H2/t10-,12-,13-/m1/s1 PUVBDYZJWIEJKE-RAIGVLPGSA-N 238215 US9402837, 25 Lysosomal acid glucosylceramidase Homo sapiens 18630 44960 4.5 US Patent 10.7270/Q2MS3RPB aid1803175 US9402837 Wustman, BA Amicus Therapeutics, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238215&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 67509941 340131615 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50005066 CO[C@@H]1O[C@@H](CO)[C@@H](Oc2cccnc2S[C@@H]2[C@H](CO)O[C@@H](OC)[C@@H](O)[C@H]2O)[C@H](O)[C@@H]1O InChI=1S/C19H29NO11S/c1-27-18-13(25)11(23)15(9(6-21)30-18)29-8-4-3-5-20-17(8)32-16-10(7-22)31-19(28-2)14(26)12(16)24/h3-5,9-16,18-19,21-26H,6-7H2,1-2H3/t9-,10-,11+,12+,13-,14-,15+,16+,18+,19+/m0/s1 HROKSROBZYCPMH-QJSXMGQDSA-N 50421365 CHEMBL2303777 Lysosomal acid glucosylceramidase Homo sapiens 5500000 ChEMBL 10.1016/0960-894X(95)00111-6 10.7270/Q22B8Z09 Knapp, S; Dong, Y; Rupitz, K; Withers, SG TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50421365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50421365&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 71717833 164150240 CHEMBL2303777 ZINC95564577 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003203 OCC12OC(Nc3ccccc3)=NC1C(O)C(O)C2O InChI=1S/C13H16N2O5/c16-6-13-10(8(17)9(18)11(13)19)15-12(20-13)14-7-4-2-1-3-5-7/h1-5,8-11,16-19H,6H2,(H,14,15) PSFQMRKUJZUIRS-UHFFFAOYSA-N 50283602 6a-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol::CHEMBL86772 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283602&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 21479008 104125259 CHEMBL86772 ZINC36323414 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003207 NC1C(O)C(O)C(O)C1O InChI=1S/C5H11NO4/c6-1-2(7)4(9)5(10)3(1)8/h1-5,7-10H,6H2 LZCRRHQKPAEPKL-UHFFFAOYSA-N 50283600 5-Amino-cyclopentane-1,2,3,4-tetraol::CHEMBL87120 Lysosomal acid glucosylceramidase Homo sapiens 7780 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283600&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search AOL 2F7Q 13880378 104125257 CHEMBL87120 ZINC34173977 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003208 OC1C(O)C2OC(Nc3ccccc3)=NC2C1O InChI=1S/C12H14N2O4/c15-8-7-11(10(17)9(8)16)18-12(14-7)13-6-4-2-1-3-5-6/h1-5,7-11,15-17H,(H,13,14) KKMTTWOORXFHAR-UHFFFAOYSA-N 50283601 2-Phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol::CHEMBL86865 Lysosomal acid glucosylceramidase Homo sapiens 2160 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283601&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44322665 104125258 CHEMBL86865 ZINC36323399 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003212 OCC1C(O)C(O)C2OC(Nc3ccccc3)=NC12 InChI=1S/C13H16N2O4/c16-6-8-9-12(11(18)10(8)17)19-13(15-9)14-7-4-2-1-3-5-7/h1-5,8-12,16-18H,6H2,(H,14,15) HVHMVEURTGZSLQ-UHFFFAOYSA-N 50283603 4-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-5,6-diol::CHEMBL313375 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283603&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44322890 104125260 CHEMBL313375 ZINC40688978 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003213 OCC1(O)C(O)C(O)C2N=C(Nc3ccccc3)OC12 InChI=1S/C13H16N2O5/c16-6-13(19)10(18)9(17)8-11(13)20-12(15-8)14-7-4-2-1-3-5-7/h1-5,8-11,16-19H,6H2,(H,14,15) WWMAKEJMUWTUCR-UHFFFAOYSA-N 50283604 6-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol::CHEMBL88408 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283604&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44322630 104125261 CHEMBL88408 ZINC40457102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003226 NC1C(O)C(O)C(O)C1(O)CO InChI=1S/C6H13NO5/c7-4-2(9)3(10)5(11)6(4,12)1-8/h2-5,8-12H,1,7H2 FFHSAAAKCQFNFB-UHFFFAOYSA-N 50283598 5-Amino-1-hydroxymethyl-cyclopentane-1,2,3,4-tetraol::CHEMBL88413 Lysosomal acid glucosylceramidase Homo sapiens 29300 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283598&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9815399 104125255 CHEMBL88413 ZINC40457127 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50001473 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 LXBIFEVIBLOUGU-JGWLITMVSA-N 18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US9181184, 1::dNM Lysosomal acid glucosylceramidase Homo sapiens 300000 5 ChEMBL 10.1016/S0960-894X(00)80648-4 10.7270/Q2TH8MKB Berger, A; Dax, K; Gradnig, G; Grassberger, V; Stütz, AE; Ungerank, M; Legler, G; Bause, E TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DNJ 1DIE,1DOG,1I75,1OIM,2J77,2JKE,2PWD,3GBE,3GXT 29435 46518429 44369 CHEMBL307429 4642 C16843 ZINC03794714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50001477 O[C@H]1CN[C@H](CF)[C@@H](O)[C@@H]1O InChI=1S/C6H12FNO3/c7-1-3-5(10)6(11)4(9)2-8-3/h3-6,8-11H,1-2H2/t3-,4+,5-,6-/m1/s1 GRCJBMPQQMMCPE-JGWLITMVSA-N 50280030 (2S,3R,4R,5S)-2-Fluoromethyl-piperidine-3,4,5-triol::CHEMBL111326 Lysosomal acid glucosylceramidase Homo sapiens 600000 5 ChEMBL 10.1016/S0960-894X(00)80648-4 10.7270/Q2TH8MKB Berger, A; Dax, K; Gradnig, G; Grassberger, V; Stütz, AE; Ungerank, M; Legler, G; Bause, E TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280030&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11116404 104121734 CHEMBL111326 ZINC13687199 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50001474 OC1CCN2C[C@H](O)[C@@H](O)[C@H](O)C12 InChI=1S/C8H15NO4/c10-4-1-2-9-3-5(11)7(12)8(13)6(4)9/h4-8,10-13H,1-3H2/t4?,5-,6?,7+,8+/m0/s1 JDVVGAQPNNXQDW-SHIRPBDBSA-N 50280031 (6S,7R,8R)-Octahydro-indolizine-1,6,7,8-tetraol::CHEMBL421040 Lysosomal acid glucosylceramidase Homo sapiens 900 5 ChEMBL 10.1016/S0960-894X(00)80648-4 10.7270/Q2TH8MKB Berger, A; Dax, K; Gradnig, G; Grassberger, V; Stütz, AE; Ungerank, M; Legler, G; Bause, E TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280031&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44338548 104121735 73400 CHEMBL421040 ZINC36323445 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50001475 CCC(O)[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C8H17NO4/c1-2-4(10)6-8(13)7(12)5(11)3-9-6/h4-13H,2-3H2,1H3/t4?,5-,6+,7+,8+/m0/s1 BBVGWVBGOXTUDE-XUQKIGAKSA-N 50280029 (2R,3R,4R,5S)-2-(1-Hydroxy-propyl)-piperidine-3,4,5-triol::CHEMBL108656 Lysosomal acid glucosylceramidase Homo sapiens 42000 5 ChEMBL 10.1016/S0960-894X(00)80648-4 10.7270/Q2TH8MKB Berger, A; Dax, K; Gradnig, G; Grassberger, V; Stütz, AE; Ungerank, M; Legler, G; Bause, E TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280029&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44338547 104121733 CHEMBL108656 ZINC26953433 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50462932 OC1CCN2C[C@H](O)[C@@H](O)[C@H](O)C12 InChI=1S/C8H15NO4/c10-4-1-2-9-3-5(11)7(12)8(13)6(4)9/h4-8,10-13H,1-3H2/t4?,5-,6?,7+,8+/m0/s1 JDVVGAQPNNXQDW-SHIRPBDBSA-N 50280031 (6S,7R,8R)-Octahydro-indolizine-1,6,7,8-tetraol::CHEMBL421040 Lysosomal acid glucosylceramidase Homo sapiens 1500 5 ChEMBL 10.1016/S0960-894X(00)80648-4 10.7270/Q2TH8MKB Berger, A; Dax, K; Gradnig, G; Grassberger, V; Stütz, AE; Ungerank, M; Legler, G; Bause, E TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280031&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44338548 104121735 73400 CHEMBL421040 ZINC36323445 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50462934 CCC(O)[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C8H17NO4/c1-2-4(10)6-8(13)7(12)5(11)3-9-6/h4-13H,2-3H2,1H3/t4?,5-,6+,7+,8+/m0/s1 BBVGWVBGOXTUDE-XUQKIGAKSA-N 50280029 (2R,3R,4R,5S)-2-(1-Hydroxy-propyl)-piperidine-3,4,5-triol::CHEMBL108656 Lysosomal acid glucosylceramidase Homo sapiens 630000 5 ChEMBL 10.1016/S0960-894X(00)80648-4 10.7270/Q2TH8MKB Berger, A; Dax, K; Gradnig, G; Grassberger, V; Stütz, AE; Ungerank, M; Legler, G; Bause, E TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280029&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44338547 104121733 CHEMBL108656 ZINC26953433 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50006086 O[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ RMCNETIHECSPMZ-SCDXWVJYSA-N 50182798 (3R,4r,5S)-piperidine-3,4,5-triol::1,5-Dideoxy-1,5-imino-D-xylitol::CHEMBL110830::PIPERIDINE-3,4,5-TRIOL Lysosomal acid glucosylceramidase Homo sapiens 8800 ChEMBL 10.1016/0960-894X(96)00068-6 10.7270/Q2ZS2WHG Igarashi, Y; Ichikawa, M; Ichikawa, Y TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182798&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search XDN 1V0K,1FH7,1V0M 445612 104067413 CHEMBL110830 ZINC14658010 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544564 CCC[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C10H19NO2/c1-2-3-7-9(13)8(12)6-11-10(7)4-5-10/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1 FDKSMHXBSQZVST-IWSPIJDZSA-N 285831 (6R,7R,8S)-8-propyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 13::US9796680, Example 13 Lysosomal acid glucosylceramidase Homo sapiens 15.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285831&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197720 378169468 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544565 O[C@@H]1CNC2(CC2)[C@H](CCF)[C@H]1O InChI=1S/C9H16FNO2/c10-4-1-6-8(13)7(12)5-11-9(6)2-3-9/h6-8,11-13H,1-5H2/t6-,7-,8-/m1/s1 MVUMUMOZSPIRQJ-BWZBUEFSSA-N 285832 (6R,7R,8S)-8-(2-fluoroethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 14::US9796680, Example 14 Lysosomal acid glucosylceramidase Homo sapiens 27.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285832&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197680 378169469 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544566 O[C@@H]1CNC2(CC2)[C@H](CC(F)F)[C@H]1O InChI=1S/C9H15F2NO2/c10-7(11)3-5-8(14)6(13)4-12-9(5)1-2-9/h5-8,12-14H,1-4H2/t5-,6-,8-/m1/s1 QAWQTKDITYMSEA-ATRFCDNQSA-N 285833 (6R,7R,8S)-8-(2,2-difluoroethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 15 Lysosomal acid glucosylceramidase Homo sapiens 56.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285833&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197683 378169470 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544567 O[C@@H]1CNC2(CC2)[C@H](C=C)[C@H]1O InChI=1S/C9H15NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h2,6-8,10-12H,1,3-5H2/t6-,7-,8-/m1/s1 JNIYJHDOBMNALK-BWZBUEFSSA-N 285834 (6R,7R,8S)-8-vinyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 16::US9796680, Example 16 Lysosomal acid glucosylceramidase Homo sapiens 6.80 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285834&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197774 378169471 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50080468 O[C@H]1[C@H]2CC[C@](O)(N2)[C@@H](O)[C@@H]1O InChI=1S/C7H13NO4/c9-4-3-1-2-7(12,8-3)6(11)5(4)10/h3-6,8-12H,1-2H2/t3-,4+,5-,6+,7-/m1/s1 FXFBVZOJVHCEDO-IBISWUOJSA-N 36389 8-Aza-bicyclo[3.2.1]octane-1,2,3,4-tetraol, 14::CID124434 Lysosomal acid glucosylceramidase Homo sapiens 5100 ChEMBL 10.1016/j.bmc.2014.02.057 10.7270/Q24X599T 24657053 Kato, A; Nakagome, I; Nakagawa, S; Koike, Y; Nash, RJ; Adachi, I; Hirono, S University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36389&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search CGB 2CBV,4IIE 124434 117643975 DB04658 ZINC12504453 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50080476 O[C@@H]1C[C@H]2CC[C@](O)(N2)[C@H]1O InChI=1S/C7H13NO3/c9-5-3-4-1-2-7(11,8-4)6(5)10/h4-6,8-11H,1-3H2/t4-,5-,6+,7-/m1/s1 XOCBOVUINUHZJA-MVIOUDGNSA-N 50002856 CHEMBL3233942 Lysosomal acid glucosylceramidase Homo sapiens 16000 ChEMBL 10.1016/j.bmc.2014.02.057 10.7270/Q24X599T 24657053 Kato, A; Nakagome, I; Nakagawa, S; Koike, Y; Nash, RJ; Adachi, I; Hirono, S University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50002856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50002856&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 183073 242056253 CHEMBL3233942 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50080487 O[C@H]1[C@H]2CC[C@](O)(N2)[C@H](O)[C@@H]1O InChI=1S/C7H13NO4/c9-4-3-1-2-7(12,8-3)6(11)5(4)10/h3-6,8-12H,1-2H2/t3-,4+,5-,6-,7-/m1/s1 FXFBVZOJVHCEDO-IECVIRLLSA-N 50002857 CHEMBL3233944 Lysosomal acid glucosylceramidase Homo sapiens 616000 ChEMBL 10.1016/j.bmc.2014.02.057 10.7270/Q24X599T 24657053 Kato, A; Nakagome, I; Nakagawa, S; Koike, Y; Nash, RJ; Adachi, I; Hirono, S University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50002857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50002857&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10313337 242056254 CHEMBL3233944 C10851 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50080488 O[C@@H]1[C@H]2CC[C@](O)(N2)[C@@H](O)[C@@H]1O InChI=1S/C7H13NO4/c9-4-3-1-2-7(12,8-3)6(11)5(4)10/h3-6,8-12H,1-2H2/t3-,4-,5-,6+,7-/m1/s1 FXFBVZOJVHCEDO-BNWJMWRWSA-N 50002909 CHEMBL3233945 Lysosomal acid glucosylceramidase Homo sapiens 175000 ChEMBL 10.1016/j.bmc.2014.02.057 10.7270/Q24X599T 24657053 Kato, A; Nakagome, I; Nakagawa, S; Koike, Y; Nash, RJ; Adachi, I; Hirono, S University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50002909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50002909&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10559162 242056305 CHEMBL3233945 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50080493 O[C@H]1[C@H]2CC[C@](O)(N2)[C@@H](O)[C@@H]1O InChI=1S/C7H13NO4/c9-4-3-1-2-7(12,8-3)6(11)5(4)10/h3-6,8-12H,1-2H2/t3-,4+,5-,6+,7-/m1/s1 FXFBVZOJVHCEDO-IBISWUOJSA-N 36389 8-Aza-bicyclo[3.2.1]octane-1,2,3,4-tetraol, 14::CID124434 Lysosomal acid glucosylceramidase Homo sapiens 3800 ChEMBL 10.1016/j.bmc.2014.02.057 10.7270/Q24X599T 24657053 Kato, A; Nakagome, I; Nakagawa, S; Koike, Y; Nash, RJ; Adachi, I; Hirono, S University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36389&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search CGB 2CBV,4IIE 124434 117643975 DB04658 ZINC12504453 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50080494 O[C@@H]1C[C@H]2CC[C@](O)(N2)[C@H]1O InChI=1S/C7H13NO3/c9-5-3-4-1-2-7(11,8-4)6(5)10/h4-6,8-11H,1-3H2/t4-,5-,6+,7-/m1/s1 XOCBOVUINUHZJA-MVIOUDGNSA-N 50002856 CHEMBL3233942 Lysosomal acid glucosylceramidase Homo sapiens 6300 ChEMBL 10.1016/j.bmc.2014.02.057 10.7270/Q24X599T 24657053 Kato, A; Nakagome, I; Nakagawa, S; Koike, Y; Nash, RJ; Adachi, I; Hirono, S University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50002856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50002856&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 183073 242056253 CHEMBL3233942 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50080495 O[C@H]1[C@H]2CC[C@](O)(N2)[C@H](O)[C@@H]1O InChI=1S/C7H13NO4/c9-4-3-1-2-7(12,8-3)6(11)5(4)10/h3-6,8-12H,1-2H2/t3-,4+,5-,6-,7-/m1/s1 FXFBVZOJVHCEDO-IECVIRLLSA-N 50002857 CHEMBL3233944 Lysosomal acid glucosylceramidase Homo sapiens 199000 ChEMBL 10.1016/j.bmc.2014.02.057 10.7270/Q24X599T 24657053 Kato, A; Nakagome, I; Nakagawa, S; Koike, Y; Nash, RJ; Adachi, I; Hirono, S University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50002857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50002857&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10313337 242056254 CHEMBL3233944 C10851 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50080499 O[C@@H]1[C@H]2CC[C@](O)(N2)[C@@H](O)[C@@H]1O InChI=1S/C7H13NO4/c9-4-3-1-2-7(12,8-3)6(11)5(4)10/h3-6,8-12H,1-2H2/t3-,4-,5-,6+,7-/m1/s1 FXFBVZOJVHCEDO-BNWJMWRWSA-N 50002909 CHEMBL3233945 Lysosomal acid glucosylceramidase Homo sapiens 98000 ChEMBL 10.1016/j.bmc.2014.02.057 10.7270/Q24X599T 24657053 Kato, A; Nakagome, I; Nakagawa, S; Koike, Y; Nash, RJ; Adachi, I; Hirono, S University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50002909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50002909&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10559162 242056305 CHEMBL3233945 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50102128 O[C@@H]1CN[C@H](CCCCCOCC23CC4CC(CC(C4)C2)C3)[C@H](O)[C@H]1O InChI=1S/C21H37NO4/c23-18-12-22-17(19(24)20(18)25)4-2-1-3-5-26-13-21-9-14-6-15(10-21)8-16(7-14)11-21/h14-20,22-25H,1-13H2/t14?,15?,16?,17-,18-,19+,20+,21?/m1/s1 DSUJWPNNYYUONL-WJYXQZPZSA-N 50018014 CHEMBL3289676 Lysosomal acid glucosylceramidase Homo sapiens 1.000000 ChEMBL 10.1016/j.bmcl.2014.03.069 10.7270/Q2RV0Q8B 24803362 Zoidl, M; Müller, B; Torvisco, A; Tysoe, C; Benazza, M; Siriwardena, A; Withers, SG; Wrodnigg, TM Technical University Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018014&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 45379774 103929190 CHEMBL3289676 ZINC96179030 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50102129 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 LXBIFEVIBLOUGU-JGWLITMVSA-N 18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US9181184, 1::dNM Lysosomal acid glucosylceramidase Homo sapiens 79000 ChEMBL 10.1016/j.bmcl.2014.03.069 10.7270/Q2RV0Q8B 24803362 Zoidl, M; Müller, B; Torvisco, A; Tysoe, C; Benazza, M; Siriwardena, A; Withers, SG; Wrodnigg, TM Technical University Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DNJ 1DIE,1DOG,1I75,1OIM,2J77,2JKE,2PWD,3GBE,3GXT 29435 46518429 44369 CHEMBL307429 4642 C16843 ZINC03794714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50102130 O[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ RMCNETIHECSPMZ-SCDXWVJYSA-N 50182798 (3R,4r,5S)-piperidine-3,4,5-triol::1,5-Dideoxy-1,5-imino-D-xylitol::CHEMBL110830::PIPERIDINE-3,4,5-TRIOL Lysosomal acid glucosylceramidase Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2014.03.069 10.7270/Q2RV0Q8B 24803362 Zoidl, M; Müller, B; Torvisco, A; Tysoe, C; Benazza, M; Siriwardena, A; Withers, SG; Wrodnigg, TM Technical University Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182798&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search XDN 1V0K,1FH7,1V0M 445612 104067413 CHEMBL110830 ZINC14658010 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50102131 O[C@@H]1CN[C@H](C#N)[C@H](O)[C@H]1O InChI=1S/C6H10N2O3/c7-1-3-5(10)6(11)4(9)2-8-3/h3-6,8-11H,2H2/t3-,4-,5+,6+/m1/s1 KOTKTRIZKDUYEA-ZXXMMSQZSA-N 50018016 CHEMBL3289677 Lysosomal acid glucosylceramidase Homo sapiens 34000 ChEMBL 10.1016/j.bmcl.2014.03.069 10.7270/Q2RV0Q8B 24803362 Zoidl, M; Müller, B; Torvisco, A; Tysoe, C; Benazza, M; Siriwardena, A; Withers, SG; Wrodnigg, TM Technical University Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018016&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 86298573 103929192 CHEMBL3289677 ZINC96179034 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50102132 OC[C@H]1N[C@H](C#N)[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C7H12N2O4/c8-1-3-5(11)7(13)6(12)4(2-10)9-3/h3-7,9-13H,2H2/t3-,4-,5+,6-,7-/m1/s1 WPLCPOIAQLRTDR-XUUWZHRGSA-N 50018017 CHEMBL3289678 Lysosomal acid glucosylceramidase Homo sapiens 716000 ChEMBL 10.1016/j.bmcl.2014.03.069 10.7270/Q2RV0Q8B 24803362 Zoidl, M; Müller, B; Torvisco, A; Tysoe, C; Benazza, M; Siriwardena, A; Withers, SG; Wrodnigg, TM Technical University Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018017&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 12852767 103929193 CHEMBL3289678 ZINC96179038 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50102133 CN(C)c1cccc2c(cccc12)S(=O)(=O)NC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C18H25N3O5S/c1-21(2)14-7-3-6-12-11(14)5-4-8-16(12)27(25,26)20-9-13-17(23)18(24)15(22)10-19-13/h3-8,13,15,17-20,22-24H,9-10H2,1-2H3/t13-,15-,17+,18+/m1/s1 BIZLZAFYXUTUMV-WCZJQEMASA-N 50018018 CHEMBL3289679 Lysosomal acid glucosylceramidase Homo sapiens 7.5 ChEMBL 10.1016/j.bmcl.2014.03.069 10.7270/Q2RV0Q8B 24803362 Zoidl, M; Müller, B; Torvisco, A; Tysoe, C; Benazza, M; Siriwardena, A; Withers, SG; Wrodnigg, TM Technical University Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018018&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 86298574 103929194 29067 CHEMBL3289679 ZINC96179040 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50102139 CCCCCCCCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C14H29NO3/c1-2-3-4-5-6-7-8-9-11-13(17)14(18)12(16)10-15-11/h11-18H,2-10H2,1H3/t11-,12-,13+,14+/m1/s1 WVYPOMDXOXCTJU-MQYQWHSLSA-N 50315250 (2R,3S,4S,5R)-2-nonylpiperidine-3,4,5-triol::CHEMBL1091214 Lysosomal acid glucosylceramidase Homo sapiens 2.2 ChEMBL 10.1016/j.bmcl.2014.03.069 10.7270/Q2RV0Q8B 24803362 Zoidl, M; Müller, B; Torvisco, A; Tysoe, C; Benazza, M; Siriwardena, A; Withers, SG; Wrodnigg, TM Technical University Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315250&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11988371 104149611 CHEMBL1091214 ZINC43151637 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50181199 CN(C)c1cccc2c(cccc12)S(=O)(=O)NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O InChI=1S/C18H25N3O5S/c1-21(2)15-7-3-6-12-11(15)5-4-8-16(12)27(25,26)19-9-13-17(23)18(24)14(10-22)20-13/h3-8,13-14,17-20,22-24H,9-10H2,1-2H3/t13-,14-,17?,18+/m1/s1 YQDDYECBODRLCI-HSADMQBASA-N 50100426 5-Dimethylamino-naphthalene-1-sulfonic acid ((3S,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-pyrrolidin-2-ylmethyl)-amide::CHEMBL3349996 Lysosomal acid glucosylceramidase Homo sapiens 2.4 ChEMBL 10.1016/s0960-894x(01)00209-8 10.7270/Q2JQ1097 11392550 Hermetter, A; Scholze, H; Stutz, AE; Withers, SG; Wrodnigg, TM Institut für Biochemie der Technischen Universität Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100426&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118718695 103997201 CHEMBL3349996CHEMBL280973 ZINC28763783 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50181202 CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCO InChI=1S/C14H18N2O3S/c1-16(2)13-7-3-6-12-11(13)5-4-8-14(12)20(18,19)15-9-10-17/h3-8,15,17H,9-10H2,1-2H3 OLNUFXNRCJFBMZ-UHFFFAOYSA-N 50100427 5-Dimethylamino-naphthalene-1-sulfonic acid (2-hydroxy-ethyl)-amide::CHEMBL27943 Lysosomal acid glucosylceramidase Homo sapiens 500 ChEMBL 10.1016/s0960-894x(01)00209-8 10.7270/Q2JQ1097 11392550 Hermetter, A; Scholze, H; Stutz, AE; Withers, SG; Wrodnigg, TM Institut für Biochemie der Technischen Universität Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100427&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 12910720 103997202 CHEMBL27943 ZINC28763011 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50181203 CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCC(=O)NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O InChI=1S/C24H36N4O6S/c1-28(2)20-10-6-9-17-16(20)8-7-11-21(17)35(33,34)26-13-5-3-4-12-22(30)25-14-18-23(31)24(32)19(15-29)27-18/h6-11,18-19,23-24,26-27,29,31-32H,3-5,12-15H2,1-2H3,(H,25,30)/t18-,19-,23?,24+/m1/s1 BPGCXGNVVKXISM-RJXMBQSPSA-N 50100428 6-(5-Dimethylamino-naphthalene-1-sulfonylamino)-hexanoic acid ((3S,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-pyrrolidin-2-ylmethyl)-amide::CHEMBL3349997 Lysosomal acid glucosylceramidase Homo sapiens 2.1 ChEMBL 10.1016/s0960-894x(01)00209-8 10.7270/Q2JQ1097 11392550 Hermetter, A; Scholze, H; Stutz, AE; Withers, SG; Wrodnigg, TM Institut für Biochemie der Technischen Universität Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100428&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118718696 103997203 CHEMBL3349997CHEMBL27760 ZINC28763511 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50178163 OC[C@H]1N[C@H](CNC(=O)c2cccc3ccccc23)[C@@H](O)[C@H]1O InChI=1S/C17H20N2O4/c20-9-14-16(22)15(21)13(19-14)8-18-17(23)12-7-3-5-10-4-1-2-6-11(10)12/h1-7,13-16,19-22H,8-9H2,(H,18,23)/t13-,14-,15?,16+/m1/s1 PTVOZHMLKATFRC-GXRBRPDZSA-N 50099003 CHEMBL3350093::Naphthalene-1-carboxylic acid ((3S,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-pyrrolidin-2-ylmethyl)-amide Lysosomal acid glucosylceramidase Homo sapiens 550 ChEMBL 10.1016/s0960-894x(01)00126-3 10.7270/Q2222T12 11327590 Wrodnigg, TM; Withers, SG; Stutz, AE Technische Universität Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099003&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118718746 103995934 CHEMBL3350093CHEMBL407994 ZINC26005184 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50178164 CCCCCCCCCCCC(=O)NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O InChI=1S/C18H36N2O4/c1-2-3-4-5-6-7-8-9-10-11-16(22)19-12-14-17(23)18(24)15(13-21)20-14/h14-15,17-18,20-21,23-24H,2-13H2,1H3,(H,19,22)/t14-,15-,17?,18+/m1/s1 DTRSDZHNDHKQMW-PXVWFRPOSA-N 50099005 CHEMBL3350087::Dodecanoic acid ((3S,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-pyrrolidin-2-ylmethyl)-amide Lysosomal acid glucosylceramidase Homo sapiens 100 ChEMBL 10.1016/s0960-894x(01)00126-3 10.7270/Q2222T12 11327590 Wrodnigg, TM; Withers, SG; Stutz, AE Technische Universität Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099005&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118718742 103995936 CHEMBL3350087CHEMBL10219 ZINC36323381 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50178165 CCN(CC)c1ccc2cc(C(=O)NC[C@H]3N[C@H](CO)[C@H](O)[C@@H]3O)c(=O)oc2c1 InChI=1S/C20H27N3O6/c1-3-23(4-2)12-6-5-11-7-13(20(28)29-16(11)8-12)19(27)21-9-14-17(25)18(26)15(10-24)22-14/h5-8,14-15,17-18,22,24-26H,3-4,9-10H2,1-2H3,(H,21,27)/t14-,15-,17?,18+/m1/s1 IITRDZNECDODIZ-PXVWFRPOSA-N 50099006 7-Diethylamino-2-oxo-2H-chromene-3-carboxylic acid ((R)-(3R,5S)-3,4-dihydroxy-5-hydroxymethyl-pyrrolidin-2-ylmethyl)-amide::CHEMBL3350092 Lysosomal acid glucosylceramidase Homo sapiens 1.2 ChEMBL 10.1016/s0960-894x(01)00126-3 10.7270/Q2222T12 11327590 Wrodnigg, TM; Withers, SG; Stutz, AE Technische Universität Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099006&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118718745 103995937 CHEMBL3350092CHEMBL10131 ZINC26005317 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50178166 OC[C@H]1N[C@@H](CNC(=O)CCc2ccccc2)[C@@H](O)[C@H]1O InChI=1S/C15H22N2O4/c18-9-12-15(21)14(20)11(17-12)8-16-13(19)7-6-10-4-2-1-3-5-10/h1-5,11-12,14-15,17-18,20-21H,6-9H2,(H,16,19)/t11-,12+,14?,15-/m0/s1 XXVVDFLXGRVOFK-KNUOEEMSSA-N 50099004 CHEMBL3350088::N-((3S,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-pyrrolidin-2-ylmethyl)-3-phenyl-propionamide Lysosomal acid glucosylceramidase Homo sapiens 150 ChEMBL 10.1016/s0960-894x(01)00126-3 10.7270/Q2222T12 11327590 Wrodnigg, TM; Withers, SG; Stutz, AE Technische Universität Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099004&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118718743 103995935 CHEMBL3350088CHEMBL274669 ZINC26006349 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50178167 OC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5+,6?/m1/s1 PFYHYHZGDNWFIF-VRPWFDPXSA-N 50099008 (2R,3S,4S)-2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol::CHEMBL469844 Lysosomal acid glucosylceramidase Homo sapiens 200 ChEMBL 10.1016/s0960-894x(01)00126-3 10.7270/Q2222T12 11327590 Wrodnigg, TM; Withers, SG; Stutz, AE Technische Universität Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099008&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10261406 103995939 CHEMBL469844CHEMBL10437 ZINC05766623 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50178168 NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O InChI=1S/C6H14N2O3/c7-1-3-5(10)6(11)4(2-9)8-3/h3-6,8-11H,1-2,7H2/t3-,4-,5?,6+/m1/s1 NJOZFAFEQVQFJI-CERMHHMHSA-N 50099009 (3S,4S,5R)-2-Aminomethyl-5-hydroxymethyl-pyrrolidine-3,4-diol::BDBM50204612::CHEMBL3350086 Lysosomal acid glucosylceramidase Homo sapiens 25 ChEMBL 10.1016/s0960-894x(01)00126-3 10.7270/Q2222T12 11327590 Wrodnigg, TM; Withers, SG; Stutz, AE Technische Universität Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099009&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 12103488 103995940 CHEMBL9745CHEMBL3350086 ZINC26003639 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50178169 OC[C@H]1N[C@H](CNS(=O)(=O)c2cccc3ccccc23)[C@@H](O)[C@H]1O InChI=1S/C16H20N2O5S/c19-9-13-16(21)15(20)12(18-13)8-17-24(22,23)14-7-3-5-10-4-1-2-6-11(10)14/h1-7,12-13,15-21H,8-9H2/t12-,13-,15?,16+/m1/s1 FYXOYENTWNJLGI-IGUCELINSA-N 50099007 CHEMBL3350089::Naphthalene-1-sulfonic acid ((R)-(3R,5S)-3,4-dihydroxy-5-hydroxymethyl-pyrrolidin-2-ylmethyl)-amide Lysosomal acid glucosylceramidase Homo sapiens 100 ChEMBL 10.1016/s0960-894x(01)00126-3 10.7270/Q2222T12 11327590 Wrodnigg, TM; Withers, SG; Stutz, AE Technische Universität Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099007&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118718744 103995938 CHEMBL3350089CHEMBL10478 ZINC26010655 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239091 Cc1ccccc1-c1ccc(COCCCCCN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1 InChI=1S/C25H35NO5/c1-18-7-3-4-8-21(18)20-11-9-19(10-12-20)17-31-14-6-2-5-13-26-15-23(28)25(30)24(29)22(26)16-27/h3-4,7-12,22-25,27-30H,2,5-6,13-17H2,1H3/t22-,23+,24-,25-/m1/s1 VZJFARCTRJANNN-ZFFYZDHPSA-N 50028221 CHEMBL3354041 Lysosomal acid glucosylceramidase Homo sapiens 70 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028221&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719903 313065418 CHEMBL3354041 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239097 COc1ccc(cc1)-c1ccc(COCCCCCN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1 InChI=1S/C25H35NO6/c1-31-21-11-9-20(10-12-21)19-7-5-18(6-8-19)17-32-14-4-2-3-13-26-15-23(28)25(30)24(29)22(26)16-27/h5-12,22-25,27-30H,2-4,13-17H2,1H3/t22-,23+,24-,25-/m1/s1 BSXLSTWHMGWCHH-ZFFYZDHPSA-N 50028222 CHEMBL3354042 Lysosomal acid glucosylceramidase Homo sapiens 2500 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028222&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719904 313065419 CHEMBL3354042 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239116 COc1cccc(c1)-c1ccc(COCCCCCN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1 InChI=1S/C25H35NO6/c1-31-21-7-5-6-20(14-21)19-10-8-18(9-11-19)17-32-13-4-2-3-12-26-15-23(28)25(30)24(29)22(26)16-27/h5-11,14,22-25,27-30H,2-4,12-13,15-17H2,1H3/t22-,23+,24-,25-/m1/s1 KSCBNPOXGKLPEB-ZFFYZDHPSA-N 50028223 CHEMBL3354043 Lysosomal acid glucosylceramidase Homo sapiens 2500 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028223&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411147 312528534 CHEMBL3354043 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239132 COc1ccccc1-c1ccc(COCCCCCN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1 InChI=1S/C25H35NO6/c1-31-23-8-4-3-7-20(23)19-11-9-18(10-12-19)17-32-14-6-2-5-13-26-15-22(28)25(30)24(29)21(26)16-27/h3-4,7-12,21-22,24-25,27-30H,2,5-6,13-17H2,1H3/t21-,22+,24-,25-/m1/s1 XEZREDYRCTYQGC-PEISPCAHSA-N 50028224 CHEMBL3354044 Lysosomal acid glucosylceramidase Homo sapiens 600 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028224&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411135 103937560 CHEMBL3354044 ZINC27559777 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239139 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccc(cc1)C#N InChI=1S/C25H32N2O5/c26-14-18-4-8-20(9-5-18)21-10-6-19(7-11-21)17-32-13-3-1-2-12-27-15-23(29)25(31)24(30)22(27)16-28/h4-11,22-25,28-31H,1-3,12-13,15-17H2/t22-,23+,24-,25-/m1/s1 CHMJMOCFEUVONE-ZFFYZDHPSA-N 50028225 CHEMBL3354045 Lysosomal acid glucosylceramidase Homo sapiens 350 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028225&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719905 103937561 CHEMBL3354045 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239150 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1cccc(c1)C#N InChI=1S/C25H32N2O5/c26-14-19-5-4-6-21(13-19)20-9-7-18(8-10-20)17-32-12-3-1-2-11-27-15-23(29)25(31)24(30)22(27)16-28/h4-10,13,22-25,28-31H,1-3,11-12,15-17H2/t22-,23+,24-,25-/m1/s1 PASBETRJWMRBPP-ZFFYZDHPSA-N 50028226 CHEMBL3354046 Lysosomal acid glucosylceramidase Homo sapiens 700 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028226&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719906 103937562 CHEMBL3354046 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239161 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccccc1C#N InChI=1S/C25H32N2O5/c26-14-20-6-2-3-7-21(20)19-10-8-18(9-11-19)17-32-13-5-1-4-12-27-15-23(29)25(31)24(30)22(27)16-28/h2-3,6-11,22-25,28-31H,1,4-5,12-13,15-17H2/t22-,23+,24-,25-/m1/s1 UPTPKEASQZRVIR-ZFFYZDHPSA-N 50028228 CHEMBL3354047 Lysosomal acid glucosylceramidase Homo sapiens 600 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028228&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411136 313065420 CHEMBL3354047 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239164 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccc(F)cc1 InChI=1S/C24H32FNO5/c25-20-10-8-19(9-11-20)18-6-4-17(5-7-18)16-31-13-3-1-2-12-26-14-22(28)24(30)23(29)21(26)15-27/h4-11,21-24,27-30H,1-3,12-16H2/t21-,22+,23-,24-/m1/s1 PGOGHEZNHFQKSP-UEQSERJNSA-N 50028229 CHEMBL3354048 Lysosomal acid glucosylceramidase Homo sapiens 400 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028229&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719907 313065421 CHEMBL3354048 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239167 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1cccc(F)c1 InChI=1S/C24H32FNO5/c25-20-6-4-5-19(13-20)18-9-7-17(8-10-18)16-31-12-3-1-2-11-26-14-22(28)24(30)23(29)21(26)15-27/h4-10,13,21-24,27-30H,1-3,11-12,14-16H2/t21-,22+,23-,24-/m1/s1 VYGIZBXHTDCYFB-UEQSERJNSA-N 50028230 CHEMBL3354049 Lysosomal acid glucosylceramidase Homo sapiens 250 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028230&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719908 313065422 CHEMBL3354049 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239174 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccccc1F InChI=1S/C24H32FNO5/c25-20-7-3-2-6-19(20)18-10-8-17(9-11-18)16-31-13-5-1-4-12-26-14-22(28)24(30)23(29)21(26)15-27/h2-3,6-11,21-24,27-30H,1,4-5,12-16H2/t21-,22+,23-,24-/m1/s1 UTSWRZLFROEVIR-UEQSERJNSA-N 50028231 CHEMBL3354050 Lysosomal acid glucosylceramidase Homo sapiens 600 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028231&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719909 313065423 CHEMBL3354050 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239177 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccc(Cl)cc1 InChI=1S/C24H32ClNO5/c25-20-10-8-19(9-11-20)18-6-4-17(5-7-18)16-31-13-3-1-2-12-26-14-22(28)24(30)23(29)21(26)15-27/h4-11,21-24,27-30H,1-3,12-16H2/t21-,22+,23-,24-/m1/s1 WHMRDWKWVDYZNI-UEQSERJNSA-N 50028232 CHEMBL3354051 Lysosomal acid glucosylceramidase Homo sapiens 500 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028232&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719910 313065424 CHEMBL3354051 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239180 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccc(cc1)C(F)(F)F InChI=1S/C25H32F3NO5/c26-25(27,28)20-10-8-19(9-11-20)18-6-4-17(5-7-18)16-34-13-3-1-2-12-29-14-22(31)24(33)23(32)21(29)15-30/h4-11,21-24,30-33H,1-3,12-16H2/t21-,22+,23-,24-/m1/s1 OKDRGJWUVVWQBR-UEQSERJNSA-N 50028233 CHEMBL3354052 Lysosomal acid glucosylceramidase Homo sapiens 800 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028233&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719911 313065425 CHEMBL3354052 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239183 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C26H31F6NO5/c27-25(28,29)19-10-18(11-20(12-19)26(30,31)32)17-6-4-16(5-7-17)15-38-9-3-1-2-8-33-13-22(35)24(37)23(36)21(33)14-34/h4-7,10-12,21-24,34-37H,1-3,8-9,13-15H2/t21-,22+,23-,24-/m1/s1 QNRQAUQEJQHXSC-UEQSERJNSA-N 50028234 CHEMBL3354053 Lysosomal acid glucosylceramidase Homo sapiens 800 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028234&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719912 313065426 CHEMBL3354053 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239186 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccc2OCOc2c1 InChI=1S/C25H33NO7/c27-14-20-24(29)25(30)21(28)13-26(20)10-2-1-3-11-31-15-17-4-6-18(7-5-17)19-8-9-22-23(12-19)33-16-32-22/h4-9,12,20-21,24-25,27-30H,1-3,10-11,13-16H2/t20-,21+,24-,25-/m1/s1 CJZGTRIZBSILBI-RRJCBXKSSA-N 50028235 CHEMBL3354054 Lysosomal acid glucosylceramidase Homo sapiens 500 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028235&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719913 313065427 CHEMBL3354054 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239189 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccc2OCCOc2c1 InChI=1S/C26H35NO7/c28-16-21-25(30)26(31)22(29)15-27(21)10-2-1-3-11-32-17-18-4-6-19(7-5-18)20-8-9-23-24(14-20)34-13-12-33-23/h4-9,14,21-22,25-26,28-31H,1-3,10-13,15-17H2/t21-,22+,25-,26-/m1/s1 GMGNEDCNRHODKX-USXZWKKNSA-N 50028236 CHEMBL3354055 Lysosomal acid glucosylceramidase Homo sapiens 250 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028236&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719914 313065428 CHEMBL3354055 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239192 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccc2OCCCOc2c1 InChI=1S/C27H37NO7/c29-17-22-26(31)27(32)23(30)16-28(22)11-2-1-3-12-33-18-19-5-7-20(8-6-19)21-9-10-24-25(15-21)35-14-4-13-34-24/h5-10,15,22-23,26-27,29-32H,1-4,11-14,16-18H2/t22-,23+,26-,27-/m1/s1 FGUXCOMLHUOVQN-QGNCETNGSA-N 50028237 CHEMBL3354056 Lysosomal acid glucosylceramidase Homo sapiens 3000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028237&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search KG5 6RRW 118719915 313065429 CHEMBL3354056 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239195 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccncc1 InChI=1S/C23H32N2O5/c26-15-20-22(28)23(29)21(27)14-25(20)12-2-1-3-13-30-16-17-4-6-18(7-5-17)19-8-10-24-11-9-19/h4-11,20-23,26-29H,1-3,12-16H2/t20-,21+,22-,23-/m1/s1 UREFFIFWVQKFRH-KAOXLYBCSA-N 50028238 CHEMBL3354057 Lysosomal acid glucosylceramidase Homo sapiens 2000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028238&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719916 313065430 CHEMBL3354057 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239198 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1cccnc1 InChI=1S/C23H32N2O5/c26-15-20-22(28)23(29)21(27)14-25(20)11-2-1-3-12-30-16-17-6-8-18(9-7-17)19-5-4-10-24-13-19/h4-10,13,20-23,26-29H,1-3,11-12,14-16H2/t20-,21+,22-,23-/m1/s1 AMLQENSKNMNTMM-KAOXLYBCSA-N 50028239 CHEMBL3354058 Lysosomal acid glucosylceramidase Homo sapiens 3000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028239&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411079 313065431 CHEMBL3354058 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239201 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1cncnc1 InChI=1S/C22H31N3O5/c26-13-19-21(28)22(29)20(27)12-25(19)8-2-1-3-9-30-14-16-4-6-17(7-5-16)18-10-23-15-24-11-18/h4-7,10-11,15,19-22,26-29H,1-3,8-9,12-14H2/t19-,20+,21-,22-/m1/s1 ZHWSUXPSLGCZQT-CIAFKFPVSA-N 50028240 CHEMBL3354059 Lysosomal acid glucosylceramidase Homo sapiens 10000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028240&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719917 313065432 CHEMBL3354059 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239204 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccnc(F)c1 InChI=1S/C23H31FN2O5/c24-21-12-18(8-9-25-21)17-6-4-16(5-7-17)15-31-11-3-1-2-10-26-13-20(28)23(30)22(29)19(26)14-27/h4-9,12,19-20,22-23,27-30H,1-3,10-11,13-15H2/t19-,20+,22-,23-/m1/s1 JTKFISWXXXQDSQ-IRMYBRCSSA-N 50028241 CHEMBL3354060 Lysosomal acid glucosylceramidase Homo sapiens 2000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028241&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411081 313065433 CHEMBL3354060 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239207 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccc(F)nc1 InChI=1S/C23H31FN2O5/c24-21-9-8-18(12-25-21)17-6-4-16(5-7-17)15-31-11-3-1-2-10-26-13-20(28)23(30)22(29)19(26)14-27/h4-9,12,19-20,22-23,27-30H,1-3,10-11,13-15H2/t19-,20+,22-,23-/m1/s1 DEQNMNQGJBQUJM-IRMYBRCSSA-N 50028242 CHEMBL3354061 Lysosomal acid glucosylceramidase Homo sapiens 3000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028242&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719918 313065434 CHEMBL3354061 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239210 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccccc1-c1ccccc1 InChI=1S/C24H33NO5/c26-16-21-23(28)24(29)22(27)15-25(21)13-7-2-8-14-30-17-19-11-5-6-12-20(19)18-9-3-1-4-10-18/h1,3-6,9-12,21-24,26-29H,2,7-8,13-17H2/t21-,22+,23-,24-/m1/s1 MDUCWMYLNVPTNV-UEQSERJNSA-N 50028243 CHEMBL3354062 Lysosomal acid glucosylceramidase Homo sapiens 1250 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028243&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411076 313065435 CHEMBL3354062 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239216 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1cccc(c1)-c1ccccc1 InChI=1S/C24H33NO5/c26-16-21-23(28)24(29)22(27)15-25(21)12-5-2-6-13-30-17-18-8-7-11-20(14-18)19-9-3-1-4-10-19/h1,3-4,7-11,14,21-24,26-29H,2,5-6,12-13,15-17H2/t21-,22+,23-,24-/m1/s1 JWYVFZRNNGAAIG-UEQSERJNSA-N 50028173 CHEMBL3354063 Lysosomal acid glucosylceramidase Homo sapiens 300 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028173&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719919 103937541 CHEMBL3354063 ZINC27749101 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239219 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1C(F)(F)F)-c1ccccc1 InChI=1S/C25H32F3NO5/c26-25(27,28)20-13-18(17-7-3-1-4-8-17)9-10-19(20)16-34-12-6-2-5-11-29-14-22(31)24(33)23(32)21(29)15-30/h1,3-4,7-10,13,21-24,30-33H,2,5-6,11-12,14-16H2/t21-,22+,23-,24-/m1/s1 DWHQKLOFYPHDRY-UEQSERJNSA-N 50028181 CHEMBL3354626 Lysosomal acid glucosylceramidase Homo sapiens 200 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028181&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411071 313065397 CHEMBL3354626 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239225 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2ccccc2)c(c1)C(F)(F)F InChI=1S/C25H32F3NO5/c26-25(27,28)20-13-17(9-10-19(20)18-7-3-1-4-8-18)16-34-12-6-2-5-11-29-14-22(31)24(33)23(32)21(29)15-30/h1,3-4,7-10,13,21-24,30-33H,2,5-6,11-12,14-16H2/t21-,22+,23-,24-/m1/s1 JORKMVPNKKKNIS-UEQSERJNSA-N 50028244 CHEMBL3354627 Lysosomal acid glucosylceramidase Homo sapiens 100 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028244&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411068 103937564 CHEMBL3354627 ZINC04824610 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239231 C[C@H](OCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO)c1ccc(cc1)-c1ccccc1 InChI=1S/C25H35NO5/c1-18(19-10-12-21(13-11-19)20-8-4-2-5-9-20)31-15-7-3-6-14-26-16-23(28)25(30)24(29)22(26)17-27/h2,4-5,8-13,18,22-25,27-30H,3,6-7,14-17H2,1H3/t18-,22-,23-,24+,25+/m0/s1 DKPSDLOOZAIQNL-ZIVGMFRUSA-N 50028248 CHEMBL3354628 Lysosomal acid glucosylceramidase Homo sapiens 10000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028248&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118720304 313065436 CHEMBL3354628 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239237 C[C@@H](OCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO)c1ccc(cc1)-c1ccccc1 InChI=1S/C25H35NO5/c1-18(19-10-12-21(13-11-19)20-8-4-2-5-9-20)31-15-7-3-6-14-26-16-23(28)25(30)24(29)22(26)17-27/h2,4-5,8-13,18,22-25,27-30H,3,6-7,14-17H2,1H3/t18-,22+,23+,24-,25-/m1/s1 DKPSDLOOZAIQNL-XUAKBXRPSA-N 50028249 CHEMBL3354629 Lysosomal acid glucosylceramidase Homo sapiens 10000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028249&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118720305 313065437 CHEMBL3354629 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239243 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccccc1-c1ccccc1 InChI=1S/C24H33NO5/c26-16-21-23(28)24(29)22(27)15-25(21)13-7-2-8-14-30-17-19-11-5-6-12-20(19)18-9-3-1-4-10-18/h1,3-6,9-12,21-24,26-29H,2,7-8,13-17H2/t21-,22-,23+,24+/m0/s1 MDUCWMYLNVPTNV-CJRSTVEYSA-N 50028250 CHEMBL3354630 Lysosomal acid glucosylceramidase Homo sapiens 15000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028250&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411153 313065438 CHEMBL3354630 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239249 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1cccc(c1)-c1ccccc1 InChI=1S/C24H33NO5/c26-16-21-23(28)24(29)22(27)15-25(21)12-5-2-6-13-30-17-18-8-7-11-20(14-18)19-9-3-1-4-10-19/h1,3-4,7-11,14,21-24,26-29H,2,5-6,12-13,15-17H2/t21-,22-,23+,24+/m0/s1 JWYVFZRNNGAAIG-CJRSTVEYSA-N 50028251 CHEMBL3354631 Lysosomal acid glucosylceramidase Homo sapiens 20000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028251&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118720306 313065439 CHEMBL3354631 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239255 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CC(F)(F)CCCOCc1ccc(cc1)-c1ccccc1 InChI=1S/C24H31F2NO5/c25-24(26,16-27-13-21(29)23(31)22(30)20(27)14-28)11-4-12-32-15-17-7-9-19(10-8-17)18-5-2-1-3-6-18/h1-3,5-10,20-23,28-31H,4,11-16H2/t20-,21-,22+,23+/m0/s1 BMDCVDRGQXCITF-MYDTUXCISA-N 50028252 CHEMBL3354632 Lysosomal acid glucosylceramidase Homo sapiens 500000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028252&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118720307 313065440 CHEMBL3354632 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239261 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCC(F)(F)COCc1ccc(cc1)-c1ccccc1 InChI=1S/C24H31F2NO5/c25-24(26,11-4-12-27-13-21(29)23(31)22(30)20(27)14-28)16-32-15-17-7-9-19(10-8-17)18-5-2-1-3-6-18/h1-3,5-10,20-23,28-31H,4,11-16H2/t20-,21-,22+,23+/m0/s1 MGIKPOPLRLHKKL-MYDTUXCISA-N 50028253 CHEMBL3354633 Lysosomal acid glucosylceramidase Homo sapiens 12500 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028253&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118720308 313065441 CHEMBL3354633 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239267 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1C(F)(F)F)-c1ccccc1 InChI=1S/C25H32F3NO5/c26-25(27,28)20-13-18(17-7-3-1-4-8-17)9-10-19(20)16-34-12-6-2-5-11-29-14-22(31)24(33)23(32)21(29)15-30/h1,3-4,7-10,13,21-24,30-33H,2,5-6,11-12,14-16H2/t21-,22-,23+,24+/m0/s1 DWHQKLOFYPHDRY-CJRSTVEYSA-N 50028254 CHEMBL3354634 Lysosomal acid glucosylceramidase Homo sapiens 5000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028254&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411108 313065442 CHEMBL3354634 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239273 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2ccccc2)c(c1)C(F)(F)F InChI=1S/C25H32F3NO5/c26-25(27,28)20-13-17(9-10-19(20)18-7-3-1-4-8-18)16-34-12-6-2-5-11-29-14-22(31)24(33)23(32)21(29)15-30/h1,3-4,7-10,13,21-24,30-33H,2,5-6,11-12,14-16H2/t21-,22-,23+,24+/m0/s1 JORKMVPNKKKNIS-CJRSTVEYSA-N 50028255 CHEMBL3354635 Lysosomal acid glucosylceramidase Homo sapiens 6000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028255&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411149 313065443 CHEMBL3354635 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239279 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1F)-c1ccccc1 InChI=1S/C24H32FNO5/c25-20-13-18(17-7-3-1-4-8-17)9-10-19(20)16-31-12-6-2-5-11-26-14-22(28)24(30)23(29)21(26)15-27/h1,3-4,7-10,13,21-24,27-30H,2,5-6,11-12,14-16H2/t21-,22-,23+,24+/m0/s1 DWCDYYDNUCIAGD-CJRSTVEYSA-N 50028256 CHEMBL3354636 Lysosomal acid glucosylceramidase Homo sapiens 8000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028256&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411069 313065444 CHEMBL3354636 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239285 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(c(F)c1)-c1ccccc1 InChI=1S/C24H32FNO5/c25-20-13-17(9-10-19(20)18-7-3-1-4-8-18)16-31-12-6-2-5-11-26-14-22(28)24(30)23(29)21(26)15-27/h1,3-4,7-10,13,21-24,27-30H,2,5-6,11-12,14-16H2/t21-,22-,23+,24+/m0/s1 IRIRASPSMMWZOM-CJRSTVEYSA-N 50028257 CHEMBL3354637 Lysosomal acid glucosylceramidase Homo sapiens 6000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028257&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 101882900 313065445 CHEMBL3354637 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239293 CCCCN1C[C@H](O)[C@@H](O)[C@@H](O)[C@H]1CO InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9+,10-/m1/s1 UQRORFVVSGFNRO-XFWSIPNHSA-N 50312528 CHEMBL1086997::N-Butyl-D-galacto-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 320000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 501391 104146889 CHEMBL1086997 ZINC13719785 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239296 OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2 InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20+,21-,22?/m1/s1 XVYLNHVEAOOEGI-BDEFQLHKSA-N 50312529 CHEMBL1088158::N-[5-(Adamantan-1-yl-methoxy)-pentyl]-D-galacto-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 200 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312529&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44820249 104146890 CHEMBL1088158 ZINC49089776 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239299 OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccccc1 InChI=1S/C24H33NO5/c26-16-21-23(28)24(29)22(27)15-25(21)13-5-2-6-14-30-17-18-9-11-20(12-10-18)19-7-3-1-4-8-19/h1,3-4,7-12,21-24,26-29H,2,5-6,13-17H2/t21-,22+,23+,24-/m1/s1 IYBACZJBAZUVGN-NAVOZUGXSA-N 50028258 CHEMBL3354638 Lysosomal acid glucosylceramidase Homo sapiens 200000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028258&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411065 313065446 CHEMBL3354638 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239301 CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 UQRORFVVSGFNRO-UTINFBMNSA-N 18355 (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol::CHEMBL1029::MIGLUSTAT::N-Butyl-DNJ::US9181184, 5 Lysosomal acid glucosylceramidase Homo sapiens 400000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18355&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NBV 5IEF,2V3D 51634 46518432 50381 CHEMBL1029 DB00419 4841 ZINC03794711 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239305 CC(C)=CCC\C(C)=C\CC\C(C)=C\CCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C27H49NO5/c1-21(2)11-8-12-22(3)13-9-14-23(4)15-10-18-33-17-7-5-6-16-28-19-25(30)27(32)26(31)24(28)20-29/h11,13,15,24-27,29-32H,5-10,12,14,16-20H2,1-4H3/b22-13+,23-15+/t24-,25-,26+,27+/m0/s1 NPVJKFWTZRIYHO-ROSHKRJISA-N 50028259 CHEMBL3354033 Lysosomal acid glucosylceramidase Homo sapiens 50000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028259&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719897 313065447 CHEMBL3354033 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239308 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccccc1 InChI=1S/C18H29NO5/c20-12-15-17(22)18(23)16(21)11-19(15)9-5-2-6-10-24-13-14-7-3-1-4-8-14/h1,3-4,7-8,15-18,20-23H,2,5-6,9-13H2/t15-,16-,17+,18+/m0/s1 JLJXOROVAFNSCP-WNRNVDISSA-N 50028260 CHEMBL3354034 Lysosomal acid glucosylceramidase Homo sapiens 10000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028260&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719898 313065448 CHEMBL3354034 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238870 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cn1)-c1ccccc1 InChI=1S/C23H32N2O5/c26-15-20-22(28)23(29)21(27)14-25(20)11-5-2-6-12-30-16-19-10-9-18(13-24-19)17-7-3-1-4-8-17/h1,3-4,7-10,13,20-23,26-29H,2,5-6,11-12,14-16H2/t20-,21+,22-,23-/m1/s1 BGTJHDMTRWMJKT-KAOXLYBCSA-N 50028174 CHEMBL3354064 Lysosomal acid glucosylceramidase Homo sapiens 1500 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028174&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411080 313065390 CHEMBL3354064 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238873 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CC(F)(F)CCCOCc1ccc(cc1)-c1ccccc1 InChI=1S/C24H31F2NO5/c25-24(26,16-27-13-21(29)23(31)22(30)20(27)14-28)11-4-12-32-15-17-7-9-19(10-8-17)18-5-2-1-3-6-18/h1-3,5-10,20-23,28-31H,4,11-16H2/t20-,21+,22-,23-/m1/s1 BMDCVDRGQXCITF-KAOXLYBCSA-N 50028175 CHEMBL3354620 Lysosomal acid glucosylceramidase Homo sapiens 125 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028175&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411077 313065391 CHEMBL3354620 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238879 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCC(F)(F)COCc1ccc(cc1)-c1ccccc1 InChI=1S/C24H31F2NO5/c25-24(26,11-4-12-27-13-21(29)23(31)22(30)20(27)14-28)16-32-15-17-7-9-19(10-8-17)18-5-2-1-3-6-18/h1-3,5-10,20-23,28-31H,4,11-16H2/t20-,21+,22-,23-/m1/s1 MGIKPOPLRLHKKL-KAOXLYBCSA-N 50028176 CHEMBL3354621 Lysosomal acid glucosylceramidase Homo sapiens 300 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028176&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 101882899 313065392 CHEMBL3354621 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238885 C[C@H](OCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccc(cc1)-c1ccccc1 InChI=1S/C25H35NO5/c1-18(19-10-12-21(13-11-19)20-8-4-2-5-9-20)31-15-7-3-6-14-26-16-23(28)25(30)24(29)22(26)17-27/h2,4-5,8-13,18,22-25,27-30H,3,6-7,14-17H2,1H3/t18-,22+,23-,24+,25+/m0/s1 DKPSDLOOZAIQNL-YHZCLNAOSA-N 50028177 CHEMBL3354622 Lysosomal acid glucosylceramidase Homo sapiens 400000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028177&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118720302 313065393 CHEMBL3354622 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238891 C[C@@H](OCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccc(cc1)-c1ccccc1 InChI=1S/C25H35NO5/c1-18(19-10-12-21(13-11-19)20-8-4-2-5-9-20)31-15-7-3-6-14-26-16-23(28)25(30)24(29)22(26)17-27/h2,4-5,8-13,18,22-25,27-30H,3,6-7,14-17H2,1H3/t18-,22-,23+,24-,25-/m1/s1 DKPSDLOOZAIQNL-GOZZSVHWSA-N 50028178 CHEMBL3354623 Lysosomal acid glucosylceramidase Homo sapiens 300 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028178&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118720303 313065394 CHEMBL3354623 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238897 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1F)-c1ccccc1 InChI=1S/C24H32FNO5/c25-20-13-18(17-7-3-1-4-8-17)9-10-19(20)16-31-12-6-2-5-11-26-14-22(28)24(30)23(29)21(26)15-27/h1,3-4,7-10,13,21-24,27-30H,2,5-6,11-12,14-16H2/t21-,22+,23-,24-/m1/s1 DWCDYYDNUCIAGD-UEQSERJNSA-N 50028179 CHEMBL3354624 Lysosomal acid glucosylceramidase Homo sapiens 250 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028179&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411072 313065395 CHEMBL3354624 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238903 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(c(F)c1)-c1ccccc1 InChI=1S/C24H32FNO5/c25-20-13-17(9-10-19(20)18-7-3-1-4-8-18)16-31-12-6-2-5-11-26-14-22(28)24(30)23(29)21(26)15-27/h1,3-4,7-10,13,21-24,27-30H,2,5-6,11-12,14-16H2/t21-,22+,23-,24-/m1/s1 IRIRASPSMMWZOM-UEQSERJNSA-N 50028180 CHEMBL3354625 Lysosomal acid glucosylceramidase Homo sapiens 200 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028180&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411074 313065396 CHEMBL3354625 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238911 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2 InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20-,21-,22?/m1/s1 XVYLNHVEAOOEGI-FAIWKWDXSA-N 50299749 (2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]-2-hydroxymethyl-piperidine-3,4,5-triol::CHEMBL574645::N-adamantanemethyloxypentyl-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 100 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299749&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9822159 104141278 CHEMBL574645 ZINC33989734 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238922 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2 InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1 XVYLNHVEAOOEGI-CURLCGPBSA-N 50312527 CHEMBL1086996::N-[5-(Adamantan-1-yl-methoxy)-pentyl]-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 2000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312527&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11258014 104146888 CHEMBL1086996 ZINC49054534 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238928 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC1CCCCC1 InChI=1S/C18H35NO5/c20-12-15-17(22)18(23)16(21)11-19(15)9-5-2-6-10-24-13-14-7-3-1-4-8-14/h14-18,20-23H,1-13H2/t15-,16+,17-,18-/m1/s1 VVGPBWJARARNSE-XMTFNYHQSA-N 50028182 CHEMBL3354014 Lysosomal acid glucosylceramidase Homo sapiens 1500 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028182&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719880 313065398 CHEMBL3354014 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238931 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCC(=O)NC12CC3CC(CC(C3)C1)C2 InChI=1S/C22H38N2O5/c25-13-17-20(28)21(29)18(26)12-24(17)5-3-1-2-4-19(27)23-22-9-14-6-15(10-22)8-16(7-14)11-22/h14-18,20-21,25-26,28-29H,1-13H2,(H,23,27)/t14?,15?,16?,17-,18+,20-,21-,22?/m1/s1 XWORIPUWULNBFL-NYHIWRMDSA-N 50028183 CHEMBL2170199 Lysosomal acid glucosylceramidase Homo sapiens 500 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028183&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10093000 313065399 CHEMBL2170199 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238958 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCC\C=C/C12CC3CC(CC(C3)C1)C2 InChI=1S/C22H37NO4/c24-14-18-20(26)21(27)19(25)13-23(18)6-4-2-1-3-5-22-10-15-7-16(11-22)9-17(8-15)12-22/h3,5,15-21,24-27H,1-2,4,6-14H2/b5-3-/t15?,16?,17?,18-,19+,20-,21-,22?/m1/s1 NGXJLNWOFGXCDY-PJLPYOADSA-N 50028184 CHEMBL3354015 Lysosomal acid glucosylceramidase Homo sapiens 500 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028184&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719881 313065400 CHEMBL3354015 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238961 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCOCC12CC3CC(CC(C3)C1)C2 InChI=1S/C23H41NO5/c25-14-19-21(27)22(28)20(26)13-24(19)5-3-1-2-4-6-29-15-23-10-16-7-17(11-23)9-18(8-16)12-23/h16-22,25-28H,1-15H2/t16?,17?,18?,19-,20+,21-,22-,23?/m1/s1 HBNZOGWTAOYFRQ-AEYPVHQJSA-N 50028185 CHEMBL3354016 Lysosomal acid glucosylceramidase Homo sapiens 200 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028185&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719882 313065401 CHEMBL3354016 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238963 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCC12CC3CC(CC(C3)C1)C2 InChI=1S/C22H39NO4/c24-14-18-20(26)21(27)19(25)13-23(18)6-4-2-1-3-5-22-10-15-7-16(11-22)9-17(8-15)12-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20-,21-,22?/m1/s1 ZIOJXWDAAUVOFR-FAIWKWDXSA-N 50028186 CHEMBL3354017 Lysosomal acid glucosylceramidase Homo sapiens 60 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028186&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57784577 312528533 CHEMBL3354017 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238966 CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C38H67NO5/c1-25(2)10-9-11-26(3)30-14-15-31-29-13-12-27-22-28(16-18-37(27,4)32(29)17-19-38(30,31)5)44-21-8-6-7-20-39-23-34(41)36(43)35(42)33(39)24-40/h12,25-26,28-36,40-43H,6-11,13-24H2,1-5H3/t26-,28+,29+,30-,31+,32+,33-,34+,35-,36-,37+,38-/m1/s1 RONFUEZMVTVAJF-VDJXWZONSA-N 50028187 CHEMBL3354018 Lysosomal acid glucosylceramidase Homo sapiens 500 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028187&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719883 313065402 CHEMBL3354018 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238969 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC1C2CC3CC(C2)CC1C3 InChI=1S/C22H39NO5/c24-12-19-21(26)22(27)20(25)11-23(19)4-2-1-3-5-28-13-18-16-7-14-6-15(9-16)10-17(18)8-14/h14-22,24-27H,1-13H2/t14?,15?,16?,17?,18?,19-,20+,21-,22-/m1/s1 BXIWEAVNUFIVND-MYHHCFDCSA-N 50028188 CHEMBL3354019 Lysosomal acid glucosylceramidase Homo sapiens 400 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028188&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719884 313065403 CHEMBL3354019 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238971 CC(C)=CCC\C(C)=C\CC\C(C)=C\CCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C27H49NO5/c1-21(2)11-8-12-22(3)13-9-14-23(4)15-10-18-33-17-7-5-6-16-28-19-25(30)27(32)26(31)24(28)20-29/h11,13,15,24-27,29-32H,5-10,12,14,16-20H2,1-4H3/b22-13+,23-15+/t24-,25+,26-,27-/m1/s1 NPVJKFWTZRIYHO-IUTRHFFQSA-N 50028189 CHEMBL3354020 Lysosomal acid glucosylceramidase Homo sapiens 2500 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028189&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719885 313065404 CHEMBL3354020 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238974 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccccc1 InChI=1S/C18H29NO5/c20-12-15-17(22)18(23)16(21)11-19(15)9-5-2-6-10-24-13-14-7-3-1-4-8-14/h1,3-4,7-8,15-18,20-23H,2,5-6,9-13H2/t15-,16+,17-,18-/m1/s1 JLJXOROVAFNSCP-XMTFNYHQSA-N 50028203 CHEMBL3354021 Lysosomal acid glucosylceramidase Homo sapiens 300 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028203&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719886 103937555 CHEMBL3354021 ZINC27207501 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238977 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc2ccccc2c1 InChI=1S/C22H31NO5/c24-14-19-21(26)22(27)20(25)13-23(19)10-4-1-5-11-28-15-16-8-9-17-6-2-3-7-18(17)12-16/h2-3,6-9,12,19-22,24-27H,1,4-5,10-11,13-15H2/t19-,20+,21-,22-/m1/s1 RTNFUFFWGXVOPY-CIAFKFPVSA-N 50028204 CHEMBL3354022 Lysosomal acid glucosylceramidase Homo sapiens 1000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028204&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719887 103937556 CHEMBL3354022 ZINC27207471 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238979 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1cc2ccccc2c2ccccc12 InChI=1S/C26H33NO5/c28-16-23-25(30)26(31)24(29)15-27(23)12-6-1-7-13-32-17-19-14-18-8-2-3-9-20(18)22-11-5-4-10-21(19)22/h2-5,8-11,14,23-26,28-31H,1,6-7,12-13,15-17H2/t23-,24+,25-,26-/m1/s1 ULWVXKHMHFFLQL-XDZVQPMWSA-N 50028205 CHEMBL3354023 Lysosomal acid glucosylceramidase Homo sapiens 10000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028205&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719888 103937557 CHEMBL3354023 ZINC27197797 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238982 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc2ccc3cccc4ccc1c2c34 InChI=1S/C28H33NO5/c30-16-23-27(32)28(33)24(31)15-29(23)13-2-1-3-14-34-17-21-10-9-20-8-7-18-5-4-6-19-11-12-22(21)26(20)25(18)19/h4-12,23-24,27-28,30-33H,1-3,13-17H2/t23-,24+,27-,28-/m1/s1 IMYBJLKJUZUZCD-WKWYISCVSA-N 50028206 CHEMBL3354024 Lysosomal acid glucosylceramidase Homo sapiens 500 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028206&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719889 103937558 CHEMBL3354024 ZINC27207652 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238985 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccccc1 InChI=1S/C24H33NO5/c26-16-21-23(28)24(29)22(27)15-25(21)13-5-2-6-14-30-17-18-9-11-20(12-10-18)19-7-3-1-4-8-19/h1,3-4,7-12,21-24,26-29H,2,5-6,13-17H2/t21-,22+,23-,24-/m1/s1 IYBACZJBAZUVGN-UEQSERJNSA-N 50028207 CHEMBL3354025 Lysosomal acid glucosylceramidase Homo sapiens 400 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028207&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411073 103937559 CHEMBL3354025 ZINC27195745 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238991 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC1CCCCC1 InChI=1S/C18H35NO5/c20-12-15-17(22)18(23)16(21)11-19(15)9-5-2-6-10-24-13-14-7-3-1-4-8-14/h14-18,20-23H,1-13H2/t15-,16-,17+,18+/m0/s1 VVGPBWJARARNSE-WNRNVDISSA-N 50028208 CHEMBL3354026 Lysosomal acid glucosylceramidase Homo sapiens 60000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028208&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719890 313065405 CHEMBL3354026 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50238994 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCC(=O)NC12CC3CC(CC(C3)C1)C2 InChI=1S/C22H38N2O5/c25-13-17-20(28)21(29)18(26)12-24(17)5-3-1-2-4-19(27)23-22-9-14-6-15(10-22)8-16(7-14)11-22/h14-18,20-21,25-26,28-29H,1-13H2,(H,23,27)/t14?,15?,16?,17-,18-,20+,21+,22?/m0/s1 XWORIPUWULNBFL-ZCRDLLLKSA-N 50028209 CHEMBL3354027 Lysosomal acid glucosylceramidase Homo sapiens 40000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028209&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719891 313065406 CHEMBL3354027 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239003 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCC\C=C/C12CC3CC(CC(C3)C1)C2 InChI=1S/C22H37NO4/c24-14-18-20(26)21(27)19(25)13-23(18)6-4-2-1-3-5-22-10-15-7-16(11-22)9-17(8-15)12-22/h3,5,15-21,24-27H,1-2,4,6-14H2/b5-3-/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1 NGXJLNWOFGXCDY-PESFBCEBSA-N 50028210 CHEMBL3354028 Lysosomal acid glucosylceramidase Homo sapiens 12000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028210&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719892 313065407 CHEMBL3354028 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239016 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCOCC12CC3CC(CC(C3)C1)C2 InChI=1S/C23H41NO5/c25-14-19-21(27)22(28)20(26)13-24(19)5-3-1-2-4-6-29-15-23-10-16-7-17(11-23)9-18(8-16)12-23/h16-22,25-28H,1-15H2/t16?,17?,18?,19-,20-,21+,22+,23?/m0/s1 HBNZOGWTAOYFRQ-ZHBFDKFYSA-N 50028211 CHEMBL3354029 Lysosomal acid glucosylceramidase Homo sapiens 5000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028211&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719893 313065408 CHEMBL3354029 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239019 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCC12CC3CC(CC(C3)C1)C2 InChI=1S/C22H39NO4/c24-14-18-20(26)21(27)19(25)13-23(18)6-4-2-1-3-5-22-10-15-7-16(11-22)9-17(8-15)12-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1 ZIOJXWDAAUVOFR-CURLCGPBSA-N 50028212 CHEMBL3354030 Lysosomal acid glucosylceramidase Homo sapiens 25000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028212&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719894 313065409 CHEMBL3354030 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239025 CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C38H67NO5/c1-25(2)10-9-11-26(3)30-14-15-31-29-13-12-27-22-28(16-18-37(27,4)32(29)17-19-38(30,31)5)44-21-8-6-7-20-39-23-34(41)36(43)35(42)33(39)24-40/h12,25-26,28-36,40-43H,6-11,13-24H2,1-5H3/t26-,28+,29+,30-,31+,32+,33+,34+,35-,36-,37+,38-/m1/s1 RONFUEZMVTVAJF-VGNYGVJBSA-N 50028213 CHEMBL3354031 Lysosomal acid glucosylceramidase Homo sapiens 15000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028213&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719895 313065410 CHEMBL3354031 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239034 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC1C2CC3CC(C2)CC1C3 InChI=1S/C22H39NO5/c24-12-19-21(26)22(27)20(25)11-23(19)4-2-1-3-5-28-13-18-16-7-14-6-15(9-16)10-17(18)8-14/h14-22,24-27H,1-13H2/t14?,15?,16?,17?,18?,19-,20-,21+,22+/m0/s1 BXIWEAVNUFIVND-JOJQPZRSSA-N 50028214 CHEMBL3354032 Lysosomal acid glucosylceramidase Homo sapiens 10000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028214&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719896 313065411 CHEMBL3354032 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239041 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc2ccccc2c1 InChI=1S/C22H31NO5/c24-14-19-21(26)22(27)20(25)13-23(19)10-4-1-5-11-28-15-16-8-9-17-6-2-3-7-18(17)12-16/h2-3,6-9,12,19-22,24-27H,1,4-5,10-11,13-15H2/t19-,20-,21+,22+/m0/s1 RTNFUFFWGXVOPY-FNAHDJPLSA-N 50028215 CHEMBL3354035 Lysosomal acid glucosylceramidase Homo sapiens 50000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028215&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719899 313065412 CHEMBL3354035 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239045 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1cc2ccccc2c2ccccc12 InChI=1S/C26H33NO5/c28-16-23-25(30)26(31)24(29)15-27(23)12-6-1-7-13-32-17-19-14-18-8-2-3-9-20(18)22-11-5-4-10-21(19)22/h2-5,8-11,14,23-26,28-31H,1,6-7,12-13,15-17H2/t23-,24-,25+,26+/m0/s1 ULWVXKHMHFFLQL-QEGGNFSNSA-N 50028216 CHEMBL3354036 Lysosomal acid glucosylceramidase Homo sapiens 600000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028216&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719900 313065413 CHEMBL3354036 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239050 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc2ccc3cccc4ccc1c2c34 InChI=1S/C28H33NO5/c30-16-23-27(32)28(33)24(31)15-29(23)13-2-1-3-14-34-17-21-10-9-20-8-7-18-5-4-6-19-11-12-22(21)26(20)25(18)19/h4-12,23-24,27-28,30-33H,1-3,13-17H2/t23-,24-,27+,28+/m0/s1 IMYBJLKJUZUZCD-KBJUPQRZSA-N 50028217 CHEMBL3354037 Lysosomal acid glucosylceramidase Homo sapiens 15000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028217&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719901 313065414 CHEMBL3354037 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239055 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(cc1)-c1ccccc1 InChI=1S/C24H33NO5/c26-16-21-23(28)24(29)22(27)15-25(21)13-5-2-6-14-30-17-18-9-11-20(12-10-18)19-7-3-1-4-8-19/h1,3-4,7-12,21-24,26-29H,2,5-6,13-17H2/t21-,22-,23+,24+/m0/s1 IYBACZJBAZUVGN-CJRSTVEYSA-N 50028218 CHEMBL3354038 Lysosomal acid glucosylceramidase Homo sapiens 20000 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028218&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411070 313065415 CHEMBL3354038 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239075 Cc1ccc(cc1)-c1ccc(COCCCCCN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1 InChI=1S/C25H35NO5/c1-18-5-9-20(10-6-18)21-11-7-19(8-12-21)17-31-14-4-2-3-13-26-15-23(28)25(30)24(29)22(26)16-27/h5-12,22-25,27-30H,2-4,13-17H2,1H3/t22-,23+,24-,25-/m1/s1 YMWWYTOTURKGDE-ZFFYZDHPSA-N 50028219 CHEMBL3354039 Lysosomal acid glucosylceramidase Homo sapiens 250 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028219&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719902 313065416 CHEMBL3354039 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50239086 Cc1cccc(c1)-c1ccc(COCCCCCN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1 InChI=1S/C25H35NO5/c1-18-6-5-7-21(14-18)20-10-8-19(9-11-20)17-31-13-4-2-3-12-26-15-23(28)25(30)24(29)22(26)16-27/h5-11,14,22-25,27-30H,2-4,12-13,15-17H2,1H3/t22-,23+,24-,25-/m1/s1 GBGOUGJOHMBDPJ-ZFFYZDHPSA-N 50028220 CHEMBL3354040 Lysosomal acid glucosylceramidase Homo sapiens 250 ChEMBL 10.1021/jm501181z 10.7270/Q20003PT 25250725 Ghisaidoobe, AT; van den Berg, RJ; Butt, SS; Strijland, A; Donker-Koopman, WE; Scheij, S; van den Nieuwendijk, AM; Koomen, GJ; van Loevezijn, A; Leemhuis, M; Wennekes, T; van der Stelt, M; van der Marel, GA; van Boeckel, CA; Aerts, JM; Overkleeft, HS Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028220&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118411140 313065417 CHEMBL3354040 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50272215 OCC(O)CCCCC(O)CC(O)CCC[C@@H](O)[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C18H37NO8/c20-9-13(24)5-2-1-4-11(22)8-12(23)6-3-7-15(25)16-18(27)17(26)14(10-21)19-16/h11-27H,1-10H2/t11?,12?,13?,14-,15-,16-,17-,18-/m1/s1 ABLRAGJKLQYRRX-LXHJOMHSSA-N 50242067 CHEMBL469435::alpha-1-C-(1,10,13-Trihydroxytridecyl)-1,4-dideoxy-1,4-imino-D-arabinitol Lysosomal acid glucosylceramidase Homo sapiens 970000 ChEMBL 10.1021/np0499721 10.7270/Q2Q52PD8 15165148 Asano, N; Ikeda, K; Kasahara, M; Arai, Y; Kizu, H Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242067&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11773821 104098939 CHEMBL469435 ZINC36424755 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50370657 COC(=O)CCCCCCCCCCCCCCCSC1=N[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O1 InChI=1S/C24H43NO7S/c1-30-19(27)15-13-11-9-7-5-3-2-4-6-8-10-12-14-16-33-24-25-23-22(32-24)21(29)20(28)18(17-26)31-23/h18,20-23,26,28-29H,2-17H2,1H3/t18-,20-,21+,22-,23+/m1/s1 SMENMHUXWSBEAT-IFPLKCGESA-N 50101402 CHEMBL3393927 Lysosomal acid glucosylceramidase Homo sapiens 33000 7 ChEMBL 10.1016/j.ejmech.2014.11.002 10.7270/Q2H996ZT 25461326 Castilla, J; Rísquez, R; Higaki, K; Nanba, E; Ohno, K; Suzuki, Y; Díaz, Y; Ortiz Mellet, C; García Fernández, JM; Castillón, S Universitat Rovira i Virgili http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101402&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118725788 318490818 CHEMBL3393927 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50370658 OC[C@H]1O[C@@H]2N=C(O[C@@H]2[C@@H](O)[C@@H]1O)SCCCCCCCCCCCCCCCCI InChI=1S/C23H42INO5S/c24-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-31-23-25-22-21(30-23)20(28)19(27)18(17-26)29-22/h18-22,26-28H,1-17H2/t18-,19-,20+,21-,22+/m1/s1 KRVOPWUJYRUGHK-BDHVOXNPSA-N 50101401 CHEMBL3393928 Lysosomal acid glucosylceramidase Homo sapiens 230000 7 ChEMBL 10.1016/j.ejmech.2014.11.002 10.7270/Q2H996ZT 25461326 Castilla, J; Rísquez, R; Higaki, K; Nanba, E; Ohno, K; Suzuki, Y; Díaz, Y; Ortiz Mellet, C; García Fernández, JM; Castillón, S Universitat Rovira i Virgili http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101401&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118725789 318490817 CHEMBL3393928 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50370659 OC[C@H]1O[C@@H]2N=C(O[C@@H]2[C@@H](O)[C@@H]1O)SCCCCCCCCCCCCCCCCF InChI=1S/C23H42FNO5S/c24-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-31-23-25-22-21(30-23)20(28)19(27)18(17-26)29-22/h18-22,26-28H,1-17H2/t18-,19-,20+,21-,22+/m1/s1 CROBGKVKJCOLFO-BDHVOXNPSA-N 50101398 CHEMBL3393930 Lysosomal acid glucosylceramidase Homo sapiens 3900 7 ChEMBL 10.1016/j.ejmech.2014.11.002 10.7270/Q2H996ZT 25461326 Castilla, J; Rísquez, R; Higaki, K; Nanba, E; Ohno, K; Suzuki, Y; Díaz, Y; Ortiz Mellet, C; García Fernández, JM; Castillón, S Universitat Rovira i Virgili http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101398&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118725791 318490814 CHEMBL3393930 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50370660 OC[C@H]1O[C@@H]2N=C(O[C@@H]2[C@@H](O)[C@@H]1O)SCCCCCCCCCCCCCCCC(O)=O InChI=1S/C23H41NO7S/c25-16-17-19(28)20(29)21-22(30-17)24-23(31-21)32-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-18(26)27/h17,19-22,25,28-29H,1-16H2,(H,26,27)/t17-,19-,20+,21-,22+/m1/s1 AVIPPTCISHRDPY-VOFPXKNKSA-N 50101403 CHEMBL3393932 Lysosomal acid glucosylceramidase Homo sapiens 420000 7 ChEMBL 10.1016/j.ejmech.2014.11.002 10.7270/Q2H996ZT 25461326 Castilla, J; Rísquez, R; Higaki, K; Nanba, E; Ohno, K; Suzuki, Y; Díaz, Y; Ortiz Mellet, C; García Fernández, JM; Castillón, S Universitat Rovira i Virgili http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101403&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118725793 318490819 CHEMBL3393932 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50370661 COC(=O)CCCCCCCCCCCCCCCSC1=N[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O1 InChI=1S/C24H43NO7S/c1-30-19(27)15-13-11-9-7-5-3-2-4-6-8-10-12-14-16-33-24-25-23-22(32-24)21(29)20(28)18(17-26)31-23/h18,20-23,26,28-29H,2-17H2,1H3/t18-,20-,21+,22-,23+/m1/s1 SMENMHUXWSBEAT-IFPLKCGESA-N 50101402 CHEMBL3393927 Lysosomal acid glucosylceramidase Homo sapiens 300000 5.5 ChEMBL 10.1016/j.ejmech.2014.11.002 10.7270/Q2H996ZT 25461326 Castilla, J; Rísquez, R; Higaki, K; Nanba, E; Ohno, K; Suzuki, Y; Díaz, Y; Ortiz Mellet, C; García Fernández, JM; Castillón, S Universitat Rovira i Virgili http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101402&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118725788 318490818 CHEMBL3393927 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50370662 OC[C@H]1O[C@@H]2N=C(O[C@@H]2[C@@H](O)[C@@H]1O)SCCCCCCCCCCCCCCCCI InChI=1S/C23H42INO5S/c24-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-31-23-25-22-21(30-23)20(28)19(27)18(17-26)29-22/h18-22,26-28H,1-17H2/t18-,19-,20+,21-,22+/m1/s1 KRVOPWUJYRUGHK-BDHVOXNPSA-N 50101401 CHEMBL3393928 Lysosomal acid glucosylceramidase Homo sapiens >1000000 5.5 ChEMBL 10.1016/j.ejmech.2014.11.002 10.7270/Q2H996ZT 25461326 Castilla, J; Rísquez, R; Higaki, K; Nanba, E; Ohno, K; Suzuki, Y; Díaz, Y; Ortiz Mellet, C; García Fernández, JM; Castillón, S Universitat Rovira i Virgili http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101401&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118725789 318490817 CHEMBL3393928 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50370663 OC[C@H]1O[C@@H]2N=C(O[C@@H]2[C@@H](O)[C@@H]1O)SCCCCCCCCCCCCCCCCF InChI=1S/C23H42FNO5S/c24-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-31-23-25-22-21(30-23)20(28)19(27)18(17-26)29-22/h18-22,26-28H,1-17H2/t18-,19-,20+,21-,22+/m1/s1 CROBGKVKJCOLFO-BDHVOXNPSA-N 50101398 CHEMBL3393930 Lysosomal acid glucosylceramidase Homo sapiens 27000 5.5 ChEMBL 10.1016/j.ejmech.2014.11.002 10.7270/Q2H996ZT 25461326 Castilla, J; Rísquez, R; Higaki, K; Nanba, E; Ohno, K; Suzuki, Y; Díaz, Y; Ortiz Mellet, C; García Fernández, JM; Castillón, S Universitat Rovira i Virgili http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101398&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118725791 318490814 CHEMBL3393930 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50370664 OC[C@H]1O[C@@H]2N=C(O[C@@H]2[C@@H](O)[C@@H]1O)SCCCCCCCCCCCCCCCC(O)=O InChI=1S/C23H41NO7S/c25-16-17-19(28)20(29)21-22(30-17)24-23(31-21)32-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-18(26)27/h17,19-22,25,28-29H,1-16H2,(H,26,27)/t17-,19-,20+,21-,22+/m1/s1 AVIPPTCISHRDPY-VOFPXKNKSA-N 50101403 CHEMBL3393932 Lysosomal acid glucosylceramidase Homo sapiens >1000000 5.5 ChEMBL 10.1016/j.ejmech.2014.11.002 10.7270/Q2H996ZT 25461326 Castilla, J; Rísquez, R; Higaki, K; Nanba, E; Ohno, K; Suzuki, Y; Díaz, Y; Ortiz Mellet, C; García Fernández, JM; Castillón, S Universitat Rovira i Virgili http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101403&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118725793 318490819 CHEMBL3393932 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50462926 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 LXBIFEVIBLOUGU-JGWLITMVSA-N 18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US9181184, 1::dNM Lysosomal acid glucosylceramidase Homo sapiens 300000 5 ChEMBL 10.1016/S0960-894X(00)80648-4 10.7270/Q2TH8MKB Berger, A; Dax, K; Gradnig, G; Grassberger, V; Stütz, AE; Ungerank, M; Legler, G; Bause, E TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DNJ 1DIE,1DOG,1I75,1OIM,2J77,2JKE,2PWD,3GBE,3GXT 29435 46518429 44369 CHEMBL307429 4642 C16843 ZINC03794714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50462931 C[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5-,6-/m1/s1 VYOCYWDJTQRZLC-JGWLITMVSA-N 50280032 (2R,3R,4R,5S)-2-Methyl-piperidine-3,4,5-triol::1,6-dideoxynojirimycin::CHEMBL324632 Lysosomal acid glucosylceramidase Homo sapiens 780000 5 ChEMBL 10.1016/S0960-894X(00)80648-4 10.7270/Q2TH8MKB Berger, A; Dax, K; Gradnig, G; Grassberger, V; Stütz, AE; Ungerank, M; Legler, G; Bause, E TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280032&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10351835 104121736 CHEMBL324632 ZINC13687194 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50462933 O[C@H]1CN[C@H](CF)[C@@H](O)[C@@H]1O InChI=1S/C6H12FNO3/c7-1-3-5(10)6(11)4(9)2-8-3/h3-6,8-11H,1-2H2/t3-,4+,5-,6-/m1/s1 GRCJBMPQQMMCPE-JGWLITMVSA-N 50280030 (2S,3R,4R,5S)-2-Fluoromethyl-piperidine-3,4,5-triol::CHEMBL111326 Lysosomal acid glucosylceramidase Homo sapiens 380000 5 ChEMBL 10.1016/S0960-894X(00)80648-4 10.7270/Q2TH8MKB Berger, A; Dax, K; Gradnig, G; Grassberger, V; Stütz, AE; Ungerank, M; Legler, G; Bause, E TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280030&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11116404 104121734 CHEMBL111326 ZINC13687199 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50480602 OC1CNCC(=C)C1O InChI=1S/C6H11NO2/c1-4-2-7-3-5(8)6(4)9/h5-9H,1-3H2 WALZSKJCFVSNCO-UHFFFAOYSA-N 50288854 5-Methylene-piperidine-3,4-diol::CHEMBL150938 Lysosomal acid glucosylceramidase Homo sapiens >1000000 ChEMBL 10.1016/0960-894X(96)00068-6 10.7270/Q2ZS2WHG Igarashi, Y; Ichikawa, M; Ichikawa, Y TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50288854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50288854&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44367875 104130425 CHEMBL150938 ZINC27628026 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50480626 CC1CNC[C@H](O)C1O InChI=1S/C6H13NO2/c1-4-2-7-3-5(8)6(4)9/h4-9H,2-3H2,1H3/t4?,5-,6?/m0/s1 WPRCMXASRHJGNG-XRVVJQKQSA-N 50104412 (S)-5-Methyl-piperidine-3,4-diol::CHEMBL86305 Lysosomal acid glucosylceramidase Homo sapiens 500000 ChEMBL 10.1016/0960-894X(96)00068-6 10.7270/Q2ZS2WHG Igarashi, Y; Ichikawa, M; Ichikawa, Y TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50104412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50104412&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44319486 104000351 CHEMBL86305 ZINC26574714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50480628 CCCCN1CC(O)C(O)C(O)C1 InChI=1S/C9H19NO3/c1-2-3-4-10-5-7(11)9(13)8(12)6-10/h7-9,11-13H,2-6H2,1H3 HEYWGMZXBVJFJO-UHFFFAOYSA-N 50288855 1-Butyl-piperidine-3,4,5-triol::CHEMBL152232 Lysosomal acid glucosylceramidase Homo sapiens 530000 ChEMBL 10.1016/0960-894X(96)00068-6 10.7270/Q2ZS2WHG Igarashi, Y; Ichikawa, M; Ichikawa, Y TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50288855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50288855&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44368239 104130426 CHEMBL152232 ZINC27643723 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50480631 COC1CNCC(O)C1O InChI=1S/C6H13NO3/c1-10-5-3-7-2-4(8)6(5)9/h4-9H,2-3H2,1H3 CMFIEBJULIYBDQ-UHFFFAOYSA-N 50288852 5-Methoxy-piperidine-3,4-diol::CHEMBL414447 Lysosomal acid glucosylceramidase Homo sapiens >1000000 ChEMBL 10.1016/0960-894X(96)00068-6 10.7270/Q2ZS2WHG Igarashi, Y; Ichikawa, M; Ichikawa, Y TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50288852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50288852&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44368232 104130423 CHEMBL414447 ZINC27644670 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50480634 CCCCN1CC(C)C(O)C(O)C1 InChI=1S/C10H21NO2/c1-3-4-5-11-6-8(2)10(13)9(12)7-11/h8-10,12-13H,3-7H2,1-2H3 JKZOTXGKCQKAFC-UHFFFAOYSA-N 50288853 1-Butyl-5-methyl-piperidine-3,4-diol::CHEMBL356023 Lysosomal acid glucosylceramidase Homo sapiens 80000 ChEMBL 10.1016/0960-894X(96)00068-6 10.7270/Q2ZS2WHG Igarashi, Y; Ichikawa, M; Ichikawa, Y TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50288853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50288853&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44368231 104130424 CHEMBL356023 ZINC40741441 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50476464 COC1OC(CO)C(Sc2nc(C)ccc2O)C(O)C1O InChI=1S/C13H19NO6S/c1-6-3-4-7(16)12(14-6)21-11-8(5-15)20-13(19-2)10(18)9(11)17/h3-4,8-11,13,15-18H,5H2,1-2H3 OKIMKIWJSJNMRK-UHFFFAOYSA-N 50286727 6-Hydroxymethyl-5-(3-hydroxy-6-methyl-pyridin-2-ylsulfanyl)-2-methoxy-tetrahydro-pyran-3,4-diol::CHEMBL348752 Lysosomal acid glucosylceramidase Homo sapiens 4500000 ChEMBL 10.1016/0960-894X(95)00111-6 10.7270/Q22B8Z09 Knapp, S; Dong, Y; Rupitz, K; Withers, SG TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286727&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44378065 104128298 CHEMBL348752 ZINC40720030 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50476465 COC1OC(CO)C(Sc2nc(CO)ccc2O)C(O)C1O InChI=1S/C13H19NO7S/c1-20-13-10(19)9(18)11(8(5-16)21-13)22-12-7(17)3-2-6(4-15)14-12/h2-3,8-11,13,15-19H,4-5H2,1H3 VQVMRFOLWDGUTA-UHFFFAOYSA-N 50286728 5-(3-Hydroxy-6-hydroxymethyl-pyridin-2-ylsulfanyl)-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4-diol::CHEMBL164780 Lysosomal acid glucosylceramidase Homo sapiens 4000000 ChEMBL 10.1016/0960-894X(95)00111-6 10.7270/Q22B8Z09 Knapp, S; Dong, Y; Rupitz, K; Withers, SG TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286728&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44378051 104128299 CHEMBL164780 ZINC40514734 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50476466 COC1OC(CO)C(Sc2ncccc2O)C(O)C1O InChI=1S/C12H17NO6S/c1-18-12-9(17)8(16)10(7(5-14)19-12)20-11-6(15)3-2-4-13-11/h2-4,7-10,12,14-17H,5H2,1H3 WXFTVOSJVZFZEV-UHFFFAOYSA-N 50286729 6-Hydroxymethyl-5-(3-hydroxy-pyridin-2-ylsulfanyl)-2-methoxy-tetrahydro-pyran-3,4-diol::CHEMBL165565 Lysosomal acid glucosylceramidase Homo sapiens 800000 ChEMBL 10.1016/0960-894X(95)00111-6 10.7270/Q22B8Z09 Knapp, S; Dong, Y; Rupitz, K; Withers, SG TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286729&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44377797 104128300 CHEMBL165565 ZINC40519583 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50476467 COC1OC(CO)C(Sc2nc(CN(C)C)ccc2O)C(O)C1O InChI=1S/C15H24N2O6S/c1-17(2)6-8-4-5-9(19)14(16-8)24-13-10(7-18)23-15(22-3)12(21)11(13)20/h4-5,10-13,15,18-21H,6-7H2,1-3H3 VGGJSXAGNQPFGC-UHFFFAOYSA-N 50286730 5-(6-Dimethylaminomethyl-3-hydroxy-pyridin-2-ylsulfanyl)-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4-diol::CHEMBL164849 Lysosomal acid glucosylceramidase Homo sapiens 20000000 ChEMBL 10.1016/0960-894X(95)00111-6 10.7270/Q22B8Z09 Knapp, S; Dong, Y; Rupitz, K; Withers, SG TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286730&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44377856 104128301 CHEMBL164849 ZINC40514749 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50476469 COC1OC(CO)C(Sc2ccccn2)C(O)C1O InChI=1S/C12H17NO5S/c1-17-12-10(16)9(15)11(7(6-14)18-12)19-8-4-2-3-5-13-8/h2-5,7,9-12,14-16H,6H2,1H3 YCATXUWYPZPSFW-UHFFFAOYSA-N 50286732 6-Hydroxymethyl-2-methoxy-5-(pyridin-2-ylsulfanyl)-tetrahydro-pyran-3,4-diol::CHEMBL165680 Lysosomal acid glucosylceramidase Homo sapiens 8000000 ChEMBL 10.1016/0960-894X(95)00111-6 10.7270/Q22B8Z09 Knapp, S; Dong, Y; Rupitz, K; Withers, SG TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50286732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50286732&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44377855 104128303 CHEMBL165680 ZINC40519595 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50476966 O[C@H]1CNC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-3-1-7-2-4(9)6(11)5(3)10/h3-11H,1-2H2/t3-,4-,5+,6+/m0/s1 MRFFNLOQLBWKPJ-UNTFVMJOSA-N 50287006 Azepane-3,4,5,6-tetraol::CHEMBL13922 Lysosomal acid glucosylceramidase Homo sapiens 12800 ChEMBL 10.1016/0960-894X(96)00183-7 10.7270/Q2M32VQR Qian, X; Morís-Varas, F; Wong, CH TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50287006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50287006&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3RK 3RIL 10080697 104128577 CHEMBL13922 ZINC13479100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50554354 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 LXBIFEVIBLOUGU-JGWLITMVSA-N 18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US9181184, 1::dNM Lysosomal acid glucosylceramidase Homo sapiens 506000 ChEMBL 10.1016/j.bmc.2009.10.060 10.7270/Q2ZC82ZH 19931460 van Scherpenzeel, M; van den Berg, RJ; Donker-Koopman, WE; Liskamp, RM; Aerts, JM; Overkleeft, HS; Pieters, RJ Utrecht University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DNJ 1DIE,1DOG,1I75,1OIM,2J77,2JKE,2PWD,3GBE,3GXT 29435 46518429 44369 CHEMBL307429 4642 C16843 ZINC03794714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50554355 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCNC(=O)c1ccc(cc1)C(=O)c1ccc(OCC#C)cc1 InChI=1S/C26H30N2O7/c1-2-14-35-20-10-8-18(9-11-20)23(31)17-4-6-19(7-5-17)26(34)27-12-3-13-28-15-22(30)25(33)24(32)21(28)16-29/h1,4-11,21-22,24-25,29-30,32-33H,3,12-16H2,(H,27,34)/t21-,22+,24-,25-/m1/s1 ISWDTKRAKJESLP-PEISPCAHSA-N 50308672 CHEMBL590070::N-(Propylamide-benzophenone)-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 350 ChEMBL 10.1016/j.bmc.2009.10.060 10.7270/Q2ZC82ZH 19931460 van Scherpenzeel, M; van den Berg, RJ; Donker-Koopman, WE; Liskamp, RM; Aerts, JM; Overkleeft, HS; Pieters, RJ Utrecht University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308672&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46229704 104163033 CHEMBL590070 ZINC45337622 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50554356 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCNC(=O)CCC(=O)c1ccc(OCC#C)cc1 InChI=1S/C22H30N2O7/c1-2-12-31-16-6-4-15(5-7-16)18(26)8-9-20(28)23-10-3-11-24-13-19(27)22(30)21(29)17(24)14-25/h1,4-7,17,19,21-22,25,27,29-30H,3,8-14H2,(H,23,28)/t17-,19+,21-,22-/m1/s1 AAWCULUAQOJFJX-HGIWEUDGSA-N 50308673 CHEMBL589341::N-(Propylamide-acetophenone)-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 1650 ChEMBL 10.1016/j.bmc.2009.10.060 10.7270/Q2ZC82ZH 19931460 van Scherpenzeel, M; van den Berg, RJ; Donker-Koopman, WE; Liskamp, RM; Aerts, JM; Overkleeft, HS; Pieters, RJ Utrecht University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308673&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46229705 104163034 CHEMBL589341 ZINC45337070 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50569720 CCCCCCCCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C14H29NO3/c1-2-3-4-5-6-7-8-9-11-13(17)14(18)12(16)10-15-11/h11-18H,2-10H2,1H3/t11-,12-,13+,14+/m1/s1 WVYPOMDXOXCTJU-MQYQWHSLSA-N 50315250 (2R,3S,4S,5R)-2-nonylpiperidine-3,4,5-triol::CHEMBL1091214 Lysosomal acid glucosylceramidase Homo sapiens 2.2 ChEMBL 10.1016/j.bmc.2010.02.027 10.7270/Q24F1QVM 20231099 Schonemann, W; Gallienne, E; Compain, P; Ikeda, K; Asano, N; Martin, OR Universit£ d'Orl£ans & CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315250&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11988371 104149611 CHEMBL1091214 ZINC43151637 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50569721 CCC[C@H]1N[C@@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C9H19NO4/c1-2-3-5-7(12)9(14)8(13)6(4-11)10-5/h5-14H,2-4H2,1H3/t5-,6+,7+,8-,9-/m1/s1 WUPMYSMCQJMDRE-QMGXLNLGSA-N 50315251 (2S,3R,4R,5S,6S)-2-(hydroxymethyl)-6-propylpiperidine-3,4,5-triol::CHEMBL1089183 Lysosomal acid glucosylceramidase Homo sapiens 487000 ChEMBL 10.1016/j.bmc.2010.02.027 10.7270/Q24F1QVM 20231099 Schonemann, W; Gallienne, E; Compain, P; Ikeda, K; Asano, N; Martin, OR Universit£ d'Orl£ans & CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315251&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10352906 104149612 CHEMBL1089183 ZINC38585478 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50569722 CCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C9H19NO4/c1-2-3-5-7(12)9(14)8(13)6(4-11)10-5/h5-14H,2-4H2,1H3/t5-,6-,7+,8-,9-/m1/s1 WUPMYSMCQJMDRE-SYHAXYEDSA-N 18360 (2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-propylpiperidine-3,4,5-triol::alpha-1-C-Propyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 400000 ChEMBL 10.1016/j.bmc.2010.02.027 10.7270/Q24F1QVM 20231099 Schonemann, W; Gallienne, E; Compain, P; Ikeda, K; Asano, N; Martin, OR Universit£ d'Orl£ans & CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18360&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10932614 46518437 ZINC14967766 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50569723 CCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C8H17NO3/c1-2-3-5-7(11)8(12)6(10)4-9-5/h5-12H,2-4H2,1H3/t5-,6-,7+,8+/m1/s1 JFOGNLDWQBZRQJ-NGJRWZKOSA-N 50315252 (2R,3S,4S,5R)-2-propylpiperidine-3,4,5-triol::CHEMBL1089185 Lysosomal acid glucosylceramidase Homo sapiens 560 ChEMBL 10.1016/j.bmc.2010.02.027 10.7270/Q24F1QVM 20231099 Schonemann, W; Gallienne, E; Compain, P; Ikeda, K; Asano, N; Martin, OR Universit£ d'Orl£ans & CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315252&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46884602 104149613 CHEMBL1089185 ZINC49067388 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50569724 CCCC[C@H]1N[C@@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C10H21NO4/c1-2-3-4-6-8(13)10(15)9(14)7(5-12)11-6/h6-15H,2-5H2,1H3/t6-,7+,8+,9-,10-/m1/s1 ZSNFEMNRWFDMNU-SOYHJAILSA-N 50315253 (2S,3S,4R,5R,6S)-2-butyl-6-(hydroxymethyl)piperidine-3,4,5-triol::CHEMBL1088891 Lysosomal acid glucosylceramidase Homo sapiens 147000 ChEMBL 10.1016/j.bmc.2010.02.027 10.7270/Q24F1QVM 20231099 Schonemann, W; Gallienne, E; Compain, P; Ikeda, K; Asano, N; Martin, OR Universit£ d'Orl£ans & CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315253&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46884603 104149614 CHEMBL1088891 ZINC49067828 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50569725 CCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C10H21NO4/c1-2-3-4-6-8(13)10(15)9(14)7(5-12)11-6/h6-15H,2-5H2,1H3/t6-,7-,8+,9-,10-/m1/s1 ZSNFEMNRWFDMNU-HOTMZDKISA-N 18361 (2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidine-3,4,5-triol::alpha-1-C-Butyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 100000 ChEMBL 10.1016/j.bmc.2010.02.027 10.7270/Q24F1QVM 20231099 Schonemann, W; Gallienne, E; Compain, P; Ikeda, K; Asano, N; Martin, OR Universit£ d'Orl£ans & CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18361&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11009466 46518438 ZINC14967770 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50569726 CCCCCC[C@H]1N[C@@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C12H25NO4/c1-2-3-4-5-6-8-10(15)12(17)11(16)9(7-14)13-8/h8-17H,2-7H2,1H3/t8-,9+,10+,11-,12-/m1/s1 CNCWFVJLRHKDJX-YBXAARCKSA-N 50315254 (2R,3S,4R,5R,6S)-2-hexyl-6-(hydroxymethyl)piperidine-3,4,5-triol::CHEMBL1089194 Lysosomal acid glucosylceramidase Homo sapiens 43000 ChEMBL 10.1016/j.bmc.2010.02.027 10.7270/Q24F1QVM 20231099 Schonemann, W; Gallienne, E; Compain, P; Ikeda, K; Asano, N; Martin, OR Universit£ d'Orl£ans & CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315254&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46884604 104149615 CHEMBL1089194 ZINC49112176 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50569727 CCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C12H25NO4/c1-2-3-4-5-6-8-10(15)12(17)11(16)9(7-14)13-8/h8-17H,2-7H2,1H3/t8-,9-,10+,11-,12-/m1/s1 CNCWFVJLRHKDJX-RMPHRYRLSA-N 18362 (2R,3S,4R,5R,6R)-2-hexyl-6-(hydroxymethyl)piperidine-3,4,5-triol::alpha-1-C-Hexyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 4200 ChEMBL 10.1016/j.bmc.2010.02.027 10.7270/Q24F1QVM 20231099 Schonemann, W; Gallienne, E; Compain, P; Ikeda, K; Asano, N; Martin, OR Universit£ d'Orl£ans & CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18362&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23647981 46518439 ZINC14967774 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50569728 CCCCCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C11H23NO3/c1-2-3-4-5-6-8-10(14)11(15)9(13)7-12-8/h8-15H,2-7H2,1H3/t8-,9-,10+,11+/m1/s1 JVCIUBNETYXXOR-ZNSHCXBVSA-N 50315255 (2R,3S,4S,5R)-2-hexylpiperidine-3,4,5-triol::CHEMBL1090540 Lysosomal acid glucosylceramidase Homo sapiens 19 ChEMBL 10.1016/j.bmc.2010.02.027 10.7270/Q24F1QVM 20231099 Schonemann, W; Gallienne, E; Compain, P; Ikeda, K; Asano, N; Martin, OR Universit£ d'Orl£ans & CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315255&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46866608 104149616 CHEMBL1090540 ZINC49070593 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50591780 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 59 ChEMBL 10.1038/nchembio850 10.7270/Q2639PX9 17187079 Lieberman, RL; Wustman, BA; Huertas, P; Powe, AC; Pine, CW; Khanna, R; Schlossmacher, MG; Ringe, D; Petsko, GA Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50624744 O[C@H]1[C@H]2CC[C@](O)(N2)[C@@H](O)[C@@H]1O InChI=1S/C7H13NO4/c9-4-3-1-2-7(12,8-3)6(11)5(4)10/h3-6,8-12H,1-2H2/t3-,4+,5-,6+,7-/m1/s1 FXFBVZOJVHCEDO-IBISWUOJSA-N 36389 8-Aza-bicyclo[3.2.1]octane-1,2,3,4-tetraol, 14::CID124434 Lysosomal acid glucosylceramidase Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2010.12.106 10.7270/Q279450G 21292481 Rasmussen, TS; Allman, S; Twigg, G; Butters, TD; Jensen, HH Aarhus University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36389&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search CGB 2CBV,4IIE 124434 117643975 DB04658 ZINC12504453 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50624745 OC[C@H]1[C@H]2CC[C@](O)(N2)[C@@H](O)[C@@H]1O InChI=1S/C8H15NO4/c10-3-4-5-1-2-8(13,9-5)7(12)6(4)11/h4-7,9-13H,1-3H2/t4-,5+,6+,7-,8+/m0/s1 NLSPHUUFXPUPJJ-FMGWEMOISA-N 50337386 CHEMBL1682493::Noeurostegine Lysosomal acid glucosylceramidase Homo sapiens 400 ChEMBL 10.1016/j.bmcl.2010.12.106 10.7270/Q279450G 21292481 Rasmussen, TS; Allman, S; Twigg, G; Butters, TD; Jensen, HH Aarhus University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50337386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50337386&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 45102053 125087488 CHEMBL1682493 ZINC66100686 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50624746 CCCCN1[C@@H]2CC[C@@]1(O)[C@@H](O)[C@H](O)[C@H]2CO InChI=1S/C12H23NO4/c1-2-3-6-13-9-4-5-12(13,17)11(16)10(15)8(9)7-14/h8-11,14-17H,2-7H2,1H3/t8-,9+,10+,11-,12+/m0/s1 QWJDIYVWDIRBLX-MTVMDMGHSA-N 50337387 (1R,2S,3R,4R,5R)-8-butyl-4-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-1,2,3-triol::CHEMBL1682494 Lysosomal acid glucosylceramidase Homo sapiens 100000 ChEMBL 10.1016/j.bmcl.2010.12.106 10.7270/Q279450G 21292481 Rasmussen, TS; Allman, S; Twigg, G; Butters, TD; Jensen, HH Aarhus University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50337387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50337387&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53317039 125087489 CHEMBL1682494 ZINC66100694 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50624747 CCCCCCCCCN1[C@@H]2CC[C@@]1(O)[C@@H](O)[C@H](O)[C@H]2CO InChI=1S/C17H33NO4/c1-2-3-4-5-6-7-8-11-18-14-9-10-17(18,22)16(21)15(20)13(14)12-19/h13-16,19-22H,2-12H2,1H3/t13-,14+,15+,16-,17+/m0/s1 JKMIBPLGAZFHHV-JZAWBGDQSA-N 50337388 (1R,2S,3R,4R,5R)-4-(hydroxymethyl)-8-nonyl-8-azabicyclo[3.2.1]octane-1,2,3-triol::CHEMBL1682495 Lysosomal acid glucosylceramidase Homo sapiens 60000 ChEMBL 10.1016/j.bmcl.2010.12.106 10.7270/Q279450G 21292481 Rasmussen, TS; Allman, S; Twigg, G; Butters, TD; Jensen, HH Aarhus University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50337388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50337388&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53323661 125087490 CHEMBL1682495 ZINC66078641 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619447 OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2 InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19-,20+,21+,22?/m0/s1 XVYLNHVEAOOEGI-CURLCGPBSA-N 50312527 CHEMBL1086996::N-[5-(Adamantan-1-yl-methoxy)-pentyl]-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 2000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312527&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11258014 104146888 CHEMBL1086996 ZINC49054534 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619448 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2 InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15?,16?,17?,18-,19+,20-,21-,22?/m1/s1 XVYLNHVEAOOEGI-FAIWKWDXSA-N 50299749 (2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]-2-hydroxymethyl-piperidine-3,4,5-triol::CHEMBL574645::N-adamantanemethyloxypentyl-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 200 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299749&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9822159 104141278 CHEMBL574645 ZINC33989734 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619449 CCCCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C20H41NO5/c1-2-3-4-5-6-7-10-13-26-14-11-8-9-12-21-15-18(23)20(25)19(24)17(21)16-22/h17-20,22-25H,2-16H2,1H3/t17-,18-,19+,20+/m0/s1 SXPLUAKSZJTQBC-VNTMZGSJSA-N 50335381 CHEMBL1651639::N-Nonoxypentyl-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 12000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335381&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 51346766 125085483 CHEMBL1651639 ZINC66156758 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619450 CCCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C19H39NO5/c1-2-3-4-5-6-9-12-25-13-10-7-8-11-20-14-17(22)19(24)18(23)16(20)15-21/h16-19,21-24H,2-15H2,1H3/t16-,17-,18+,19+/m0/s1 ZDHLSZPFRBINKG-INDMIFKZSA-N 50335382 CHEMBL1651638::N-Octoxypentyl-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 15000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335382&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53325720 125085484 CHEMBL1651638 ZINC66066008 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619451 CCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C18H37NO5/c1-2-3-4-5-8-11-24-12-9-6-7-10-19-13-16(21)18(23)17(22)15(19)14-20/h15-18,20-23H,2-14H2,1H3/t15-,16-,17+,18+/m0/s1 QKGFRVNZERLSSG-WNRNVDISSA-N 50335383 CHEMBL1651637::N-Heptoxypentyl-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 40000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335383&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53317798 125085485 CHEMBL1651637 ZINC66066007 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619452 CCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C17H35NO5/c1-2-3-4-7-10-23-11-8-5-6-9-18-12-15(20)17(22)16(21)14(18)13-19/h14-17,19-22H,2-13H2,1H3/t14-,15-,16+,17+/m0/s1 RCXJPSZNTHETPE-MWDXBVQZSA-N 50335384 CHEMBL1651636::N-Hexoxypentyl-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 95000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335384&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53319115 125085486 CHEMBL1651636 ZINC66102295 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619453 CCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C16H33NO5/c1-2-3-6-9-22-10-7-4-5-8-17-11-14(19)16(21)15(20)13(17)12-18/h13-16,18-21H,2-12H2,1H3/t13-,14-,15+,16+/m0/s1 LLUQYJRYJAPGMA-CAOSSQGBSA-N 50335385 CHEMBL1651635::N-Pentoxypentyl-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 100000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335385&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53324417 125085487 CHEMBL1651635 ZINC66103718 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619454 CCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C15H31NO5/c1-2-3-8-21-9-6-4-5-7-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13-,14+,15+/m0/s1 YMYODBBUEFCWGO-BYNSBNAKSA-N 50335386 CHEMBL1651634::N-Butoxypentyl-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens >1000000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335386&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53320433 125085488 CHEMBL1651634 ZINC66103715 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619455 CCCCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C20H41NO5/c1-2-3-4-5-6-7-10-13-26-14-11-8-9-12-21-15-18(23)20(25)19(24)17(21)16-22/h17-20,22-25H,2-16H2,1H3/t17-,18+,19-,20-/m1/s1 SXPLUAKSZJTQBC-IYWMVGAKSA-N 50335387 CHEMBL1651633::N-Nonoxypentyl-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 500 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335387&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53319114 125085489 CHEMBL1651633 ZINC66103712 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619456 CCCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C19H39NO5/c1-2-3-4-5-6-9-12-25-13-10-7-8-11-20-14-17(22)19(24)18(23)16(20)15-21/h16-19,21-24H,2-15H2,1H3/t16-,17+,18-,19-/m1/s1 ZDHLSZPFRBINKG-FCGDIQPGSA-N 50335388 CHEMBL1651632::N-Octoxypentyl-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 500 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335388&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53323068 125085490 CHEMBL1651632 ZINC66102968 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619457 CCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C18H37NO5/c1-2-3-4-5-8-11-24-12-9-6-7-10-19-13-16(21)18(23)17(22)15(19)14-20/h15-18,20-23H,2-14H2,1H3/t15-,16+,17-,18-/m1/s1 QKGFRVNZERLSSG-XMTFNYHQSA-N 50335389 CHEMBL1651631::N-Heptoxypentyl-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 1750 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335389&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53317797 125085491 CHEMBL1651631 ZINC66102966 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619458 CCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C17H35NO5/c1-2-3-4-7-10-23-11-8-5-6-9-18-12-15(20)17(22)16(21)14(18)13-19/h14-17,19-22H,2-13H2,1H3/t14-,15+,16-,17-/m1/s1 RCXJPSZNTHETPE-YYIAUSFCSA-N 50335390 CHEMBL1651630::N-Hexoxypentyl-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 205000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335390&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53321623 125085492 CHEMBL1651630 ZINC66102963 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619459 CCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C16H33NO5/c1-2-3-6-9-22-10-7-4-5-8-17-11-14(19)16(21)15(20)13(17)12-18/h13-16,18-21H,2-12H2,1H3/t13-,14+,15-,16-/m1/s1 LLUQYJRYJAPGMA-QKPAOTATSA-N 50335391 CHEMBL1651629::N-Pentoxypentyl-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 705000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335391&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53323067 125085493 CHEMBL1651629 ZINC66102961 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619460 CCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO5/c1-2-3-8-21-9-6-4-5-7-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 YMYODBBUEFCWGO-LXTVHRRPSA-N 50335392 CHEMBL1651628::N-Butoxypentyl-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 30000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335392&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53325719 125085494 CHEMBL1651628 ZINC66066530 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619461 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13-,14+,15+/m0/s1 FTSCEGKYKXESFF-BYNSBNAKSA-N 50335393 CHEMBL1651627::N-Nonyl-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 50000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335393&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 25010362 125085495 CHEMBL1651627 ZINC66156319 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619462 CCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C14H29NO4/c1-2-3-4-5-6-7-8-15-9-12(17)14(19)13(18)11(15)10-16/h11-14,16-19H,2-10H2,1H3/t11-,12-,13+,14+/m0/s1 VGSQNAQYXKTCLP-IGQOVBAYSA-N 50335394 CHEMBL1651626::N-Octyl-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 25000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335394&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53320432 125085496 CHEMBL1651626 ZINC66066529 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619463 CCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C13H27NO4/c1-2-3-4-5-6-7-14-8-11(16)13(18)12(17)10(14)9-15/h10-13,15-18H,2-9H2,1H3/t10-,11-,12+,13+/m0/s1 MBQCNYZEYQQTEE-WUHRBBMRSA-N 50335395 CHEMBL1651555::N-Heptyl-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 700000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335395&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 25010186 125085497 CHEMBL1651555 ZINC66099903 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619464 CCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C12H25NO4/c1-2-3-4-5-6-13-7-10(15)12(17)11(16)9(13)8-14/h9-12,14-17H,2-8H2,1H3/t9-,10-,11+,12+/m0/s1 KRNOSIJCJVCXKU-NNYUYHANSA-N 50335396 CHEMBL1651554::N-Hexyl-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens >1000000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335396&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53323483 125085498 CHEMBL1651554 ZINC66102799 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619465 CCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C11H23NO4/c1-2-3-4-5-12-6-9(14)11(16)10(15)8(12)7-13/h8-11,13-16H,2-7H2,1H3/t8-,9-,10+,11+/m0/s1 HCZQIIVHWYFIPW-UKKRHICBSA-N 50335397 CHEMBL1651553::N-Pentyl-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens >1000000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335397&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9859470 125085499 CHEMBL1651553 ZINC03979739 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619466 CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8-,9+,10+/m0/s1 UQRORFVVSGFNRO-AXTSPUMRSA-N 50312526 CHEMBL1076754::N-Butyl-L-ido-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens >1000000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312526&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23622616 104146887 CHEMBL1076754 ZINC03957104 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619467 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 1500 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619468 CCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C14H29NO4/c1-2-3-4-5-6-7-8-15-9-12(17)14(19)13(18)11(15)10-16/h11-14,16-19H,2-10H2,1H3/t11-,12+,13-,14-/m1/s1 VGSQNAQYXKTCLP-XJFOESAGSA-N 18357 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-octylpiperidine-3,4,5-triol::N-Octyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 4000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18357&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9882040 46518434 ZINC14967758 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619469 CCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C13H27NO4/c1-2-3-4-5-6-7-14-8-11(16)13(18)12(17)10(14)9-15/h10-13,15-18H,2-9H2,1H3/t10-,11+,12-,13-/m1/s1 MBQCNYZEYQQTEE-YVECIDJPSA-N 50335398 CHEMBL1651551::N-Heptyl-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 18500 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335398&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9881659 125085500 CHEMBL1651551 ZINC66104602 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619470 CCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C12H25NO4/c1-2-3-4-5-6-13-7-10(15)12(17)11(16)9(13)8-14/h9-12,14-17H,2-8H2,1H3/t9-,10+,11-,12-/m1/s1 KRNOSIJCJVCXKU-WRWGMCAJSA-N 18356 (2R,3R,4R,5S)-1-hexyl-2-(hydroxymethyl)piperidine-3,4,5-triol::N-Hexyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 80000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18356&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 12766473 46518433 ZINC03799255 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619471 CCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C11H23NO4/c1-2-3-4-5-12-6-9(14)11(16)10(15)8(12)7-13/h8-11,13-16H,2-7H2,1H3/t8-,9+,10-,11-/m1/s1 HCZQIIVHWYFIPW-LMLFDSFASA-N 50335399 CHEMBL1651549::N-Pentyl-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 500000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335399&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 129374 125085501 CHEMBL1651549 ZINC03799253 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50619472 CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 UQRORFVVSGFNRO-UTINFBMNSA-N 18355 (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol::CHEMBL1029::MIGLUSTAT::N-Butyl-DNJ::US9181184, 5 Lysosomal acid glucosylceramidase Homo sapiens 400000 ChEMBL 10.1021/ml100192b 10.7270/Q21C1X5H 24900289 Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18355&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NBV 5IEF,2V3D 51634 46518432 50381 CHEMBL1029 DB00419 4841 ZINC03794711 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633589 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(Cc3cc4nsnc4cc3Cl)nn2)[C@@H](O)[C@@H]1O InChI=1S/C16H19ClN6O5S/c17-8-2-10-9(20-29-21-10)1-6(8)4-23-5-7(19-22-23)3-18-11-12(24)14(26)16(28)15(27)13(11)25/h1-2,5,11-16,18,24-28H,3-4H2/t11-,12-,13+,14+,15-,16- QYBZABWHQBHWPJ-KUNQJQEJSA-N 50341319 CHEMBL1766477::rel-(1R,2S,4R,5S)-6-((1-((6-chlorobenzo[c][1,2,5]thiadiazol-5-yl)methyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 17300 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341319&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937613 131344255 CHEMBL1766477 ZINC71318840 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633590 Cn1nnc2ccc(Cn3cc(CN[C@@H]4[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]4O)nn3)cc12 InChI=1S/C17H23N7O5/c1-23-11-4-8(2-3-10(11)20-21-23)6-24-7-9(19-22-24)5-18-12-13(25)15(27)17(29)16(28)14(12)26/h2-4,7,12-18,25-29H,5-6H2,1H3/t12-,13-,14+,15+,16-,17- VRTDGOGVAXEUAJ-ZDVFKUJDSA-N 50341320 CHEMBL1766478::rel-(1R,2S,4R,5S)-6-((1-((1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)methyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 114000 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341320&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937710 131344256 CHEMBL1766478 ZINC71316911 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633591 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCCCCOCc3ccccc3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C21H32N4O6/c26-17-16(18(27)20(29)21(30)19(17)28)22-11-15-12-25(24-23-15)9-5-2-6-10-31-13-14-7-3-1-4-8-14/h1,3-4,7-8,12,16-22,26-30H,2,5-6,9-11,13H2/t16-,17-,18+,19+,20-,21- WIYNAKZHFFTQNX-XLGNRPJKSA-N 50341321 CHEMBL1766479::rel-(1R,2S,4R,5S)-6-((1-(5-(benzyloxy)pentyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 10000 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341321&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937711 131344257 CHEMBL1766479 ZINC71329869 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633592 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCCC3CCCCC3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C18H32N4O5/c23-14-13(15(24)17(26)18(27)16(14)25)19-9-12-10-22(21-20-12)8-4-7-11-5-2-1-3-6-11/h10-11,13-19,23-27H,1-9H2/t13-,14-,15+,16+,17-,18- ZYYUJDXQOUDDSU-WKTMMLQWSA-N 50341322 CHEMBL1766480::rel-(1R,2S,4R,5S)-6-((1-(3-cyclohexylpropyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 4320 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341322&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937712 131344258 CHEMBL1766480 ZINC71296352 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633593 CC(C)(CO)Cn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C14H26N4O6/c1-14(2,6-19)5-18-4-7(16-17-18)3-15-8-9(20)11(22)13(24)12(23)10(8)21/h4,8-13,15,19-24H,3,5-6H2,1-2H3/t8-,9-,10+,11+,12-,13- RNUJUZPJWPDFQT-XESFAPMISA-N 50341323 CHEMBL1766481::rel-(1R,2S,4R,5S)-6-((1-(3-hydroxy-2,2-dimethylpropyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 134000 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341323&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937713 131344259 CHEMBL1766481 ZINC71329862 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633594 CCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C17H32N4O5/c1-2-3-4-5-6-7-8-21-10-11(19-20-21)9-18-12-13(22)15(24)17(26)16(25)14(12)23/h10,12-18,22-26H,2-9H2,1H3/t12-,13-,14+,15+,16-,17- GOWXONIFDQHALJ-ZDVFKUJDSA-N 50318559 (1R,2S,3r,4R,5S,6s)-6-[(1-Octyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085392 Lysosomal acid glucosylceramidase Homo sapiens 2250 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318559&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867661 104152920 CHEMBL1085392 ZINC49777326 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633595 CCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O5/c1-2-3-4-5-6-7-8-9-10-23-12-13(21-22-23)11-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- DCJWZIGHKBTFDW-OXHPVDPFSA-N 50318562 (1R,2S,3r,4R,5S,6s)-6-[(1-Decyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1082596 Lysosomal acid glucosylceramidase Homo sapiens 150 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318562&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867529 104152923 CHEMBL1082596 ZINC49777498 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633596 CCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C20H38N4O5/c1-2-3-4-5-6-7-8-9-10-11-24-13-14(22-23-24)12-21-15-16(25)18(27)20(29)19(28)17(15)26/h13,15-21,25-29H,2-12H2,1H3/t15-,16-,17+,18+,19-,20- YKRCVGFYAOXFRY-VYEXIYEWSA-N 50341324 CHEMBL1766482::rel-(1R,2S,4R,5S)-6-[[1-Undecyl-1H-1,2,3-triazol-4-yl]methylamino]-cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 60 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341324&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937714 131344260 CHEMBL1766482 ZINC71329517 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633597 COCCCOCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C16H30N4O7/c1-26-5-3-7-27-6-2-4-20-9-10(18-19-20)8-17-11-12(21)14(23)16(25)15(24)13(11)22/h9,11-17,21-25H,2-8H2,1H3/t11-,12-,13+,14+,15-,16- SCCCAZMSTIEGBM-KUNQJQEJSA-N 50341325 CHEMBL1766483::rel-(1R,2S,4R,5S)-6-((1-(3-(3-methoxypropoxy)propyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 466000 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341325&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937715 131344261 CHEMBL1766483 ZINC71316533 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633598 CCCCOCCCOCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O7/c1-2-3-7-29-9-5-10-30-8-4-6-23-12-13(21-22-23)11-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- SRGZSGUOKHANIR-OXHPVDPFSA-N 50341326 CHEMBL1766484::rel-(1R,2S,4R,5S)-6-((1-(3-(3-butoxypropoxy)propyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 181000 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341326&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937812 131344262 CHEMBL1766484 ZINC71317997 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633599 CSCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C13H24N4O5S/c1-23-4-2-3-17-6-7(15-16-17)5-14-8-9(18)11(20)13(22)12(21)10(8)19/h6,8-14,18-22H,2-5H2,1H3/t8-,9-,10+,11+,12-,13- OPHMVEZMBSDQII-XESFAPMISA-N 50341327 CHEMBL1766485::rel-(1R,2S,4R,5S)-6-((1-(3-(methylthio)propyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 44500 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341327&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937813 131344263 CHEMBL1766485 ZINC71329809 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633600 COCCCOCCCOCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O8/c1-29-6-3-8-31-10-4-9-30-7-2-5-23-12-13(21-22-23)11-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- SZWVNPAKKHSJAT-OXHPVDPFSA-N 50341328 CHEMBL1766486::rel-(1R,2S,4R,5S)-6-((1-(3-(3-(3-methoxypropoxy)propoxy)propyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 453000 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341328&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937814 131344264 CHEMBL1766486 ZINC71316885 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633601 CC(C)(C)OCCCOCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O7/c1-19(2,3)30-9-5-8-29-7-4-6-23-11-12(21-22-23)10-20-13-14(24)16(26)18(28)17(27)15(13)25/h11,13-18,20,24-28H,4-10H2,1-3H3/t13-,14-,15+,16+,17-,18- KNRZAGKAQTYBFX-WKTMMLQWSA-N 50341329 CHEMBL1766487::rel-(1R,2S,4R,5S)-6-((1-(3-(3-tert-butoxypropoxy)propyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 325000 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341329&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937815 131344265 CHEMBL1766487 ZINC71297120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633602 OCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C16H30N4O6/c21-7-5-3-1-2-4-6-20-9-10(18-19-20)8-17-11-12(22)14(24)16(26)15(25)13(11)23/h9,11-17,21-26H,1-8H2/t11-,12-,13+,14+,15-,16- BDSNJLULQHPZHE-KUNQJQEJSA-N 50341330 CHEMBL1766488::rel-(1R,2S,4R,5S)-6-((1-(7-hydroxyheptyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 5800 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341330&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937816 131344266 CHEMBL1766488 ZINC71316237 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633603 OCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O6/c24-10-8-6-4-2-1-3-5-7-9-23-12-13(21-22-23)11-20-14-15(25)17(27)19(29)18(28)16(14)26/h12,14-20,24-29H,1-11H2/t14-,15-,16+,17+,18-,19- JZEYDOMKWQQKCY-OXHPVDPFSA-N 50341331 CHEMBL1766489::rel-(1R,2S,4R,5S)-6-[[1-(10-Hydroxydecyl)-1H-1,2,3-triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 2190 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341331&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937817 131344267 CHEMBL1766489 ZINC71315843 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633604 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(Cc3cc(OCc4ccccc4)cc(OCc4ccccc4)c3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C30H34N4O7/c35-26-25(27(36)29(38)30(39)28(26)37)31-14-22-16-34(33-32-22)15-21-11-23(40-17-19-7-3-1-4-8-19)13-24(12-21)41-18-20-9-5-2-6-10-20/h1-13,16,25-31,35-39H,14-15,17-18H2/t25-,26-,27+,28+,29-,30- OIFZDLBPIABAJR-YCHSXSCJSA-N 50341332 CHEMBL1766350::rel-(1R,2S,4R,5S)-6-[(1-(3,5-Bis(benzyloxy)benzyl)-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 60 7.4 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341332&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937504 131344268 CHEMBL1766350 ZINC71329143 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633605 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCC(c3ccccc3)c3ccccc3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C24H30N4O5/c29-20-19(21(30)23(32)24(33)22(20)31)25-13-17-14-28(27-26-17)12-11-18(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,14,18-25,29-33H,11-13H2/t19-,20-,21+,22+,23-,24- HADXDSKDVGEUKQ-QJJHVYBSSA-N 50341333 CHEMBL1766470::rel-(1R,2S,4R,5S)-6-[[1-(3,3-Diphenylpropyl)-1H-1,2,3-triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 1800 7.4 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341333&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937507 131344269 CHEMBL1766470 ZINC71317982 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633606 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CC34CC5CC(CC(C5)C3)C4)nn2)[C@@H](O)[C@@H]1O InChI=1S/C20H32N4O5/c25-15-14(16(26)18(28)19(29)17(15)27)21-7-13-8-24(23-22-13)9-20-4-10-1-11(5-20)3-12(2-10)6-20/h8,10-12,14-19,21,25-29H,1-7,9H2/t10?,11?,12?,14-,15-,16+,17+,18-,19-,20? WUOWYKPGZRQBCX-ULOZQBBYSA-N 50341334 CHEMBL1766473::rel-(1R,2S,4R,5S)-6-[(1-Adamantyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 1900 7.4 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341334&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937609 131344270 CHEMBL1766473 ZINC71329516 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633607 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCCCC3CCCCC3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C19H34N4O5/c24-15-14(16(25)18(27)19(28)17(15)26)20-10-13-11-23(22-21-13)9-5-4-8-12-6-2-1-3-7-12/h11-12,14-20,24-28H,1-10H2/t14-,15-,16+,17+,18-,19- SCLOQUUDNGPMRM-OXHPVDPFSA-N 50341335 CHEMBL1766474::rel-(1R,2S,4R,5S)-6-[[1-(4-Cyclohexylbutyl)-1H-1,2,3-triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 300 7.4 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341335&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937610 131344271 CHEMBL1766474 ZINC71296365 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633608 CCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C20H38N4O5/c1-2-3-4-5-6-7-8-9-10-11-24-13-14(22-23-24)12-21-15-16(25)18(27)20(29)19(28)17(15)26/h13,15-21,25-29H,2-12H2,1H3/t15-,16-,17+,18+,19-,20- YKRCVGFYAOXFRY-VYEXIYEWSA-N 50341324 CHEMBL1766482::rel-(1R,2S,4R,5S)-6-[[1-Undecyl-1H-1,2,3-triazol-4-yl]methylamino]-cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 100 7.4 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341324&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937714 131344260 CHEMBL1766482 ZINC71329517 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633609 OCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O6/c24-10-8-6-4-2-1-3-5-7-9-23-12-13(21-22-23)11-20-14-15(25)17(27)19(29)18(28)16(14)26/h12,14-20,24-29H,1-11H2/t14-,15-,16+,17+,18-,19- JZEYDOMKWQQKCY-OXHPVDPFSA-N 50341331 CHEMBL1766489::rel-(1R,2S,4R,5S)-6-[[1-(10-Hydroxydecyl)-1H-1,2,3-triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 1300 7.4 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341331&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937817 131344267 CHEMBL1766489 ZINC71315843 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633610 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 300 7.4 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633611 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(Cc3cc(OCc4ccccc4)cc(OCc4ccccc4)c3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C30H34N4O7/c35-26-25(27(36)29(38)30(39)28(26)37)31-14-22-16-34(33-32-22)15-21-11-23(40-17-19-7-3-1-4-8-19)13-24(12-21)41-18-20-9-5-2-6-10-20/h1-13,16,25-31,35-39H,14-15,17-18H2/t25-,26-,27+,28+,29-,30- OIFZDLBPIABAJR-YCHSXSCJSA-N 50341332 CHEMBL1766350::rel-(1R,2S,4R,5S)-6-[(1-(3,5-Bis(benzyloxy)benzyl)-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 50 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341332&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937504 131344268 CHEMBL1766350 ZINC71329143 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633612 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCC(c3ccccc3)c3ccccc3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C24H30N4O5/c29-20-19(21(30)23(32)24(33)22(20)31)25-13-17-14-28(27-26-17)12-11-18(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,14,18-25,29-33H,11-13H2/t19-,20-,21+,22+,23-,24- HADXDSKDVGEUKQ-QJJHVYBSSA-N 50341333 CHEMBL1766470::rel-(1R,2S,4R,5S)-6-[[1-(3,3-Diphenylpropyl)-1H-1,2,3-triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 770 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341333&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937507 131344269 CHEMBL1766470 ZINC71317982 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633613 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CC34CC5CC(CC(C5)C3)C4)nn2)[C@@H](O)[C@@H]1O InChI=1S/C20H32N4O5/c25-15-14(16(26)18(28)19(29)17(15)27)21-7-13-8-24(23-22-13)9-20-4-10-1-11(5-20)3-12(2-10)6-20/h8,10-12,14-19,21,25-29H,1-7,9H2/t10?,11?,12?,14-,15-,16+,17+,18-,19-,20? WUOWYKPGZRQBCX-ULOZQBBYSA-N 50341334 CHEMBL1766473::rel-(1R,2S,4R,5S)-6-[(1-Adamantyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 1050 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341334&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937609 131344270 CHEMBL1766473 ZINC71329516 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633614 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCCCC3CCCCC3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C19H34N4O5/c24-15-14(16(25)18(27)19(28)17(15)26)20-10-13-11-23(22-21-13)9-5-4-8-12-6-2-1-3-7-12/h11-12,14-20,24-28H,1-10H2/t14-,15-,16+,17+,18-,19- SCLOQUUDNGPMRM-OXHPVDPFSA-N 50341335 CHEMBL1766474::rel-(1R,2S,4R,5S)-6-[[1-(4-Cyclohexylbutyl)-1H-1,2,3-triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 290 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341335&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937610 131344271 CHEMBL1766474 ZINC71296365 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633615 CCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C20H38N4O5/c1-2-3-4-5-6-7-8-9-10-11-24-13-14(22-23-24)12-21-15-16(25)18(27)20(29)19(28)17(15)26/h13,15-21,25-29H,2-12H2,1H3/t15-,16-,17+,18+,19-,20- YKRCVGFYAOXFRY-VYEXIYEWSA-N 50341324 CHEMBL1766482::rel-(1R,2S,4R,5S)-6-[[1-Undecyl-1H-1,2,3-triazol-4-yl]methylamino]-cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 50 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341324&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937714 131344260 CHEMBL1766482 ZINC71329517 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633616 OCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O6/c24-10-8-6-4-2-1-3-5-7-9-23-12-13(21-22-23)11-20-14-15(25)17(27)19(29)18(28)16(14)26/h12,14-20,24-29H,1-11H2/t14-,15-,16+,17+,18-,19- JZEYDOMKWQQKCY-OXHPVDPFSA-N 50341331 CHEMBL1766489::rel-(1R,2S,4R,5S)-6-[[1-(10-Hydroxydecyl)-1H-1,2,3-triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 890 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341331&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937817 131344267 CHEMBL1766489 ZINC71315843 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633617 CCCCCCCCCCN[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C16H33NO5/c1-2-3-4-5-6-7-8-9-10-17-11-12(18)14(20)16(22)15(21)13(11)19/h11-22H,2-10H2,1H3/t11-,12-,13+,14+,15-,16- VRJPTDKBAXVMJT-KUNQJQEJSA-N 50318560 CHEMBL1083795::N-decylaminocyclitol Lysosomal acid glucosylceramidase Homo sapiens 300 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318560&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46889930 104152921 CHEMBL1083795 ZINC49777251 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633618 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 300 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633659 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(Cc3cc(OCc4ccccc4)cc(OCc4ccccc4)c3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C30H34N4O7/c35-26-25(27(36)29(38)30(39)28(26)37)31-14-22-16-34(33-32-22)15-21-11-23(40-17-19-7-3-1-4-8-19)13-24(12-21)41-18-20-9-5-2-6-10-20/h1-13,16,25-31,35-39H,14-15,17-18H2/t25-,26-,27+,28+,29-,30- OIFZDLBPIABAJR-YCHSXSCJSA-N 50341332 CHEMBL1766350::rel-(1R,2S,4R,5S)-6-[(1-(3,5-Bis(benzyloxy)benzyl)-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 50 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341332&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937504 131344268 CHEMBL1766350 ZINC71329143 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633660 CCCCc1ncc(Cn2cc(CN[C@@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]3O)nn2)[nH]1 InChI=1S/C17H28N6O5/c1-2-3-4-11-18-5-9(20-11)7-23-8-10(21-22-23)6-19-12-13(24)15(26)17(28)16(27)14(12)25/h5,8,12-17,19,24-28H,2-4,6-7H2,1H3,(H,18,20)/t12-,13-,14+,15+,16-,17- IOWWGXCMPZJMHX-ZDVFKUJDSA-N 50341336 CHEMBL1766468::rel-(1R,2S,4R,5S,)-6-((1-((2-butyl-1H-imidazol-4-yl)methyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 237000 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341336&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937505 131344272 CHEMBL1766468 ZINC71296780 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633661 CN1CCN(Cc2cccc(Cn3cc(CN[C@@H]4[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]4O)nn3)c2)CC1 InChI=1S/C22H34N6O5/c1-26-5-7-27(8-6-26)11-14-3-2-4-15(9-14)12-28-13-16(24-25-28)10-23-17-18(29)20(31)22(33)21(32)19(17)30/h2-4,9,13,17-23,29-33H,5-8,10-12H2,1H3/t17-,18-,19+,20+,21-,22- LJMWPJJAQQTWES-RGHYKDJOSA-N 50341337 CHEMBL1766469::rel-(1R,2S,4R,5S,)-6-((1-(3-((4-methylpiperazin-1-yl)methyl)benzyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 66500 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341337&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937506 131344273 CHEMBL1766469 ZINC71329046 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633662 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCC(c3ccccc3)c3ccccc3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C24H30N4O5/c29-20-19(21(30)23(32)24(33)22(20)31)25-13-17-14-28(27-26-17)12-11-18(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,14,18-25,29-33H,11-13H2/t19-,20-,21+,22+,23-,24- HADXDSKDVGEUKQ-QJJHVYBSSA-N 50341333 CHEMBL1766470::rel-(1R,2S,4R,5S)-6-[[1-(3,3-Diphenylpropyl)-1H-1,2,3-triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 1500 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341333&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937507 131344269 CHEMBL1766470 ZINC71317982 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633663 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(Cc3cccc(I)c3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C16H21IN4O5/c17-9-3-1-2-8(4-9)6-21-7-10(19-20-21)5-18-11-12(22)14(24)16(26)15(25)13(11)23/h1-4,7,11-16,18,22-26H,5-6H2/t11-,12-,13+,14+,15-,16- ACRQOJFYZMSWME-KUNQJQEJSA-N 50341338 CHEMBL1766471::rel-(1R,2S,4R,5S)-6-((1-(3-iodobenzyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 10300 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341338&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937508 131344274 CHEMBL1766471 ZINC71297117 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633664 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCCc3nc4ccc(cc4[nH]3)C(F)(F)F)nn2)[C@@H](O)[C@@H]1O InChI=1S/C20H25F3N6O5/c21-20(22,23)9-3-4-11-12(6-9)26-13(25-11)2-1-5-29-8-10(27-28-29)7-24-14-15(30)17(32)19(34)18(33)16(14)31/h3-4,6,8,14-19,24,30-34H,1-2,5,7H2,(H,25,26)/t14-,15-,16+,17+,18-,19- LWCMKJLHTFFFAH-OXHPVDPFSA-N 50341339 CHEMBL1766472::rel-(1R,2S,4R,5S)-6-((1-(3-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)propyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 12200 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341339&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937608 131344275 CHEMBL1766472 ZINC71330329 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633665 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CC34CC5CC(CC(C5)C3)C4)nn2)[C@@H](O)[C@@H]1O InChI=1S/C20H32N4O5/c25-15-14(16(26)18(28)19(29)17(15)27)21-7-13-8-24(23-22-13)9-20-4-10-1-11(5-20)3-12(2-10)6-20/h8,10-12,14-19,21,25-29H,1-7,9H2/t10?,11?,12?,14-,15-,16+,17+,18-,19-,20? WUOWYKPGZRQBCX-ULOZQBBYSA-N 50341334 CHEMBL1766473::rel-(1R,2S,4R,5S)-6-[(1-Adamantyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 2200 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341334&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937609 131344270 CHEMBL1766473 ZINC71329516 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633666 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCCCC3CCCCC3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C19H34N4O5/c24-15-14(16(25)18(27)19(28)17(15)26)20-10-13-11-23(22-21-13)9-5-4-8-12-6-2-1-3-7-12/h11-12,14-20,24-28H,1-10H2/t14-,15-,16+,17+,18-,19- SCLOQUUDNGPMRM-OXHPVDPFSA-N 50341335 CHEMBL1766474::rel-(1R,2S,4R,5S)-6-[[1-(4-Cyclohexylbutyl)-1H-1,2,3-triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 1500 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341335&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937610 131344271 CHEMBL1766474 ZINC71296365 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633667 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(nn2)C2CSCCCSC2)[C@@H](O)[C@@H]1O InChI=1S/C15H26N4O5S2/c20-11-10(12(21)14(23)15(24)13(11)22)16-4-8-5-19(18-17-8)9-6-25-2-1-3-26-7-9/h5,9-16,20-24H,1-4,6-7H2/t10-,11-,12+,13+,14-,15- LBOWUIJJPWMMIC-JYBHGSPCSA-N 50341340 CHEMBL1766475::rel-(1R,2S,4R,5S)-6-((1-(1,5-dithiocan-3-yl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 35900 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341340&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937611 131344276 CHEMBL1766475 ZINC71296797 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50633668 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(Cc3ccc(CN4CCCCC4)cc3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C22H33N5O5/c28-18-17(19(29)21(31)22(32)20(18)30)23-10-16-13-27(25-24-16)12-15-6-4-14(5-7-15)11-26-8-2-1-3-9-26/h4-7,13,17-23,28-32H,1-3,8-12H2/t17-,18-,19+,20+,21-,22- CIFFLNMIFGLRPG-RGHYKDJOSA-N 50341341 CHEMBL1766476::rel-(1R,2S,4R,5S)-6-((1-(4-(piperidin-1-ylmethyl)benzyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol Lysosomal acid glucosylceramidase Homo sapiens 30900 5.2 ChEMBL 10.1021/jm101204u 10.7270/Q24F1R18 21370884 Diaz, L; Casas, J; Bujons, J; Llebaria, A; Delgado, A Spanish National Research Council (Consejo Superior de Investigaciones Cienti£?ficas) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341341&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52937612 131344277 CHEMBL1766476 ZINC71316530 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50660661 OCCN1CCOCC1 InChI=1S/C6H13NO2/c8-4-1-7-2-5-9-6-3-7/h8H,1-6H2 KKFDCBRMNNSAAW-UHFFFAOYSA-N 50353062 CHEMBL1821739 Lysosomal acid glucosylceramidase Homo sapiens 620000 ChEMBL 10.1016/j.bmc.2011.07.019 10.7270/Q2QZ2BB5 21862336 Burland, PA; Osborn, HM; Turkson, A University of Reading http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50353062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50353062&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 61163 136359748 67144 CHEMBL1821739 ZINC19230121 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50660662 OCCC(O)CN1CCOCC1 InChI=1S/C8H17NO3/c10-4-1-8(11)7-9-2-5-12-6-3-9/h8,10-11H,1-7H2 CFOHHMITBKLUEM-UHFFFAOYSA-N 50353063 CHEMBL1822915 Lysosomal acid glucosylceramidase Homo sapiens 640000 ChEMBL 10.1016/j.bmc.2011.07.019 10.7270/Q2QZ2BB5 21862336 Burland, PA; Osborn, HM; Turkson, A University of Reading http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50353063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50353063&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 56679802 136359749 CHEMBL1822915 ZINC72179547 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50655067 OC[C@H]1CNC[C@@H](O)[C@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6+/m1/s1 QPYJXFZUIJOGNX-PBXRRBTRSA-N 50350758 CHEMBL1818433 Lysosomal acid glucosylceramidase Homo sapiens 54000 ChEMBL 10.1016/j.bmc.2011.04.011 10.7270/Q2BC3ZWW 21546253 Kato, A; Miyauchi, S; Kato, N; Nash, RJ; Yoshimura, Y; Nakagome, I; Hirono, S; Takahata, H; Adachi, I University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350758&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search GIF 4UFH,5T9G,5T99,4CU7 10240946 136357444 CHEMBL1818433 ZINC06361525 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50655084 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 63 ChEMBL 10.1016/j.bmc.2011.04.011 10.7270/Q2BC3ZWW 21546253 Kato, A; Miyauchi, S; Kato, N; Nash, RJ; Yoshimura, Y; Nakagome, I; Hirono, S; Takahata, H; Adachi, I University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50655089 OC[C@@H]1CNC[C@H](O)[C@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m0/s1 QPYJXFZUIJOGNX-ZLUOBGJFSA-N 50263043 CHEMBL501385::L-Isofagomine Lysosomal acid glucosylceramidase Homo sapiens 8700 ChEMBL 10.1016/j.bmc.2011.04.011 10.7270/Q2BC3ZWW 21546253 Kato, A; Miyauchi, S; Kato, N; Nash, RJ; Yoshimura, Y; Nakagome, I; Hirono, S; Takahata, H; Adachi, I University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263043&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44578588 104111538 CHEMBL501385 ZINC01484929 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50655092 OC[C@H]1CNC[C@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5+,6-/m1/s1 QPYJXFZUIJOGNX-NGJCXOISSA-N 50350761 CHEMBL1818321 Lysosomal acid glucosylceramidase Homo sapiens 113000 ChEMBL 10.1016/j.bmc.2011.04.011 10.7270/Q2BC3ZWW 21546253 Kato, A; Miyauchi, S; Kato, N; Nash, RJ; Yoshimura, Y; Nakagome, I; Hirono, S; Takahata, H; Adachi, I University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350761&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10844524 136357447 CHEMBL1818321 ZINC12504403 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729997 OC[C@@H]1CN[C@@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C7H15NO4/c9-2-4-1-8-5(3-10)7(12)6(4)11/h4-12H,1-3H2 QOCWZLBXKJTSDM-UHFFFAOYSA-N 50075409 2,5-Bis-hydroxymethyl-piperidine-3,4-diol::CHEMBL3350915 Lysosomal acid glucosylceramidase Homo sapiens 66000 ChEMBL 10.1016/s0960-894x(99)00042-6 10.7270/Q2V40VQH 10098675 Schuster, M Technische Universit£t Berlin http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075409&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719204 103968509 CHEMBL3350915CHEMBL157578 ZINC40511558 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729998 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 LXBIFEVIBLOUGU-JGWLITMVSA-N 18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US9181184, 1::dNM Lysosomal acid glucosylceramidase Homo sapiens 47000 ChEMBL 10.1016/s0960-894x(99)00042-6 10.7270/Q2V40VQH 10098675 Schuster, M Technische Universit£t Berlin http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DNJ 1DIE,1DOG,1I75,1OIM,2J77,2JKE,2PWD,3GBE,3GXT 29435 46518429 44369 CHEMBL307429 4642 C16843 ZINC03794714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730001 C[C@@H]1NC[C@@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C7H15NO3/c1-4-6(10)7(11)5(3-9)2-8-4/h4-11H,2-3H2,1H3 NZPKJUPKMZLFQP-UHFFFAOYSA-N 50075410 5-Hydroxymethyl-2-methyl-piperidine-3,4-diol::CHEMBL3350914 Lysosomal acid glucosylceramidase Homo sapiens 2100 ChEMBL 10.1016/s0960-894x(99)00042-6 10.7270/Q2V40VQH 10098675 Schuster, M Technische Universit£t Berlin http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50075410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50075410&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118719203 103968510 CHEMBL3350914CHEMBL347184 ZINC36323523 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50728542 OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H10O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-5,7-10H,1H2/t2-,3-,4+,5-/m1/s1 PHOQVHQSTUBQQK-SQOUGZDYSA-N 50366565 GLUCONOLACTONE Lysosomal acid glucosylceramidase Homo sapiens 30000 ChEMBL 10.1016/s0960-894x(98)00031-6 10.7270/Q2PN9642 9871687 Therisod, H; Letourneux, Y; Therisod, M S.E.S.N.A.B., Pole Sciences et Technologie, Universit� de La Rochelle. therisod@icmo.u-psud.fr http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366565&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search LGC 3EQO,1E6X,5XXM,7D6B,2E40,4ZLG,3VIF,3AZZ,4ZOB,2W39,2VWG,4YNU,7VKF 7027 160845667 16217 DB04564 C02692 ZINC02539702 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50728547 OCC1OC(=NOC(=O)Nc2ccccc2)C(O)C(O)C1O InChI=1S/C13H16N2O7/c16-6-8-9(17)10(18)11(19)12(21-8)15-22-13(20)14-7-4-2-1-3-5-7/h1-5,8-11,16-19H,6H2,(H,14,20) GPIOBIZYEXDBSE-UHFFFAOYSA-N 50070029 (2Z)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one O-(anilinocarbonyl)oxime::CHEMBL62552 Lysosomal acid glucosylceramidase Homo sapiens 2500 ChEMBL 10.1016/s0960-894x(98)00031-6 10.7270/Q2PN9642 9871687 Therisod, H; Letourneux, Y; Therisod, M S.E.S.N.A.B., Pole Sciences et Technologie, Universit� de La Rochelle. therisod@icmo.u-psud.fr http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50070029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50070029&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3262578 103963977 CHEMBL62552 ZINC36323394 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730383 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 LXBIFEVIBLOUGU-JGWLITMVSA-N 18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US9181184, 1::dNM Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DNJ 1DIE,1DOG,1I75,1OIM,2J77,2JKE,2PWD,3GBE,3GXT 29435 46518429 44369 CHEMBL307429 4642 C16843 ZINC03794714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730384 O=C1N(CCCc2ccccc2)C(=O)c2ccccc12 InChI=1S/C17H15NO2/c19-16-14-10-4-5-11-15(14)17(20)18(16)12-6-9-13-7-2-1-3-8-13/h1-5,7-8,10-11H,6,9,12H2 VGFCDPFVPQOZJV-UHFFFAOYSA-N 50088669 2-(3-Phenyl-propyl)-isoindole-1,3-dione::CHEMBL11322 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088669&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 7663529 103987546 CHEMBL11322 ZINC05398049 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730385 O=C1N(Cc2ccccc2)C(=O)c2ccccc12 InChI=1S/C15H11NO2/c17-14-12-8-4-5-9-13(12)15(18)16(14)10-11-6-2-1-3-7-11/h1-9H,10H2 WITXFYCLPDFRNM-UHFFFAOYSA-N 50088671 2-Benzyl-isoindole-1,3-dione::2-benzylisoindoline-1,3-dione::CHEMBL416887 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088671&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 75059 103987548 CHEMBL416887 C14263 ZINC00096893 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730390 O=C1N(CCc2ccccc2)C(=O)c2ccccc12 InChI=1S/C16H13NO2/c18-15-13-8-4-5-9-14(13)16(19)17(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2 MBYLNRRTUYQZAW-UHFFFAOYSA-N 50088674 2-Phenethyl-isoindole-1,3-dione::2-phenethylisoindoline-1,3-dione::CHEMBL11452 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088674&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 348641 103987551 CHEMBL11452 ZINC00246806 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730392 Nc1cccc2C(=O)N(C(=O)c12)c1ccccc1 InChI=1S/C14H10N2O2/c15-11-8-4-7-10-12(11)14(18)16(13(10)17)9-5-2-1-3-6-9/h1-8H,15H2 IYNXMRJUAJBGGM-UHFFFAOYSA-N 31709 4-amino-2-phenyl-isoindoline-1,3-quinone::4-amino-2-phenylisoindole-1,3-dione::4-azanyl-2-phenyl-isoindole-1,3-dione::CHEMBL269410::MLS000104009::SMR000015725::cid_3448473 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31709&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3448473 252615405 CHEMBL269410 ZINC00241267 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730393 Clc1c2C(=O)N(CCCCc3ccccc3)C(=O)c2c(Cl)c(Cl)c1Cl InChI=1S/C18H13Cl4NO2/c19-13-11-12(14(20)16(22)15(13)21)18(25)23(17(11)24)9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2 GFCXRTRECNWYEP-UHFFFAOYSA-N 50088675 4,5,6,7-Tetrachloro-2-(4-phenyl-butyl)-isoindole-1,3-dione::4,5,6,7-tetrachloro-2-(4-phenylbutyl)isoindoline-1,3-dione::CHEMBL275285 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088675&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10319782 103987552 CHEMBL275285 ZINC26022764 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730394 [O-][N+](=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccccc1 InChI=1S/C14H8N2O4/c17-13-11-7-6-10(16(19)20)8-12(11)14(18)15(13)9-4-2-1-3-5-9/h1-8H HNNCFMUZZXJQLR-UHFFFAOYSA-N 50088676 5-Nitro-2-phenyl-isoindole-1,3-dione::CHEMBL273605 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088676&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 762600 103987553 CHEMBL273605 ZINC00235609 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730395 Clc1c2C(=O)N(CCCc3ccccc3)C(=O)c2c(Cl)c(Cl)c1Cl InChI=1S/C17H11Cl4NO2/c18-12-10-11(13(19)15(21)14(12)20)17(24)22(16(10)23)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2 OJTQZQWNFPOOPW-UHFFFAOYSA-N 50088677 4,5,6,7-Tetrachloro-2-(3-phenyl-propyl)-isoindole-1,3-dione::4,5,6,7-tetrachloro-2-(3-phenylpropyl)isoindoline-1,3-dione::CHEMBL11216 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088677&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10739903 103987554 CHEMBL11216 ZINC26022511 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730400 Nc1ccc2C(=O)N(C(=O)c2c1)c1ccccc1 InChI=1S/C14H10N2O2/c15-9-6-7-11-12(8-9)14(18)16(13(11)17)10-4-2-1-3-5-10/h1-8H,15H2 NCBAEHTXQVTURB-UHFFFAOYSA-N 50088681 5-Amino-2-phenyl-isoindole-1,3-dione::CHEMBL11477 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088681&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 787204 103987558 CHEMBL11477 ZINC00285195 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730401 Oc1cccc2C(=O)N(C(=O)c12)c1ccccc1 InChI=1S/C14H9NO3/c16-11-8-4-7-10-12(11)14(18)15(13(10)17)9-5-2-1-3-6-9/h1-8,16H CXPJSDRRKGBSPZ-UHFFFAOYSA-N 50088680 4-Hydroxy-2-phenyl-isoindole-1,3-dione::CHEMBL11566 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088680&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10752481 103987557 CHEMBL11566 ZINC26020844 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730404 O=C1N(C(=O)c2ccccc12)c1ccccc1 InChI=1S/C14H9NO2/c16-13-11-8-4-5-9-12(11)14(17)15(13)10-6-2-1-3-7-10/h1-9H MFUPLJQNEXUUDW-UHFFFAOYSA-N 50088679 2-Phenyl-isoindole-1,3-dione::2-phenyl-1H-isoindole-1,3(2H)-dione::2-phenylisoindoline-1,3-dione::CHEMBL9020::N-Phenylphtalimide Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088679&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 68215 103987556 CHEMBL9020 ZINC00133969 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730406 Clc1c2C(=O)N(Cc3ccccc3)C(=O)c2c(Cl)c(Cl)c1Cl InChI=1S/C15H7Cl4NO2/c16-10-8-9(11(17)13(19)12(10)18)15(22)20(14(8)21)6-7-4-2-1-3-5-7/h1-5H,6H2 MQFQHWBPMPPVNJ-UHFFFAOYSA-N 50088678 2-Benzyl-4,5,6,7-tetrachloro-isoindole-1,3-dione::2-benzyl-4,5,6,7-tetrachloroisoindoline-1,3-dione::CHEMBL11516 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088678&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 983732 103987555 CHEMBL11516 ZINC00630019 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730407 Oc1ccc2C(=O)N(C(=O)c2c1)c1ccccc1 InChI=1S/C14H9NO3/c16-10-6-7-11-12(8-10)14(18)15(13(11)17)9-4-2-1-3-5-9/h1-8,16H HCUAWJNHCZEMJS-UHFFFAOYSA-N 50088673 5-Hydroxy-2-phenyl-isoindole-1,3-dione::5-hydroxy-2-phenylisoindoline-1,3-dione::CHEMBL276030 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088673&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10823890 103987550 CHEMBL276030 ZINC26020837 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730408 Clc1c2C(=O)N(CCc3ccccc3)C(=O)c2c(Cl)c(Cl)c1Cl InChI=1S/C16H9Cl4NO2/c17-11-9-10(12(18)14(20)13(11)19)16(23)21(15(9)22)7-6-8-4-2-1-3-5-8/h1-5H,6-7H2 OLHDFCBCGYRAKY-UHFFFAOYSA-N 50088670 4,5,6,7-Tetrachloro-2-phenethyl-isoindole-1,3-dione::4,5,6,7-tetrachloro-2-phenethylisoindoline-1,3-dione::CHEMBL11766 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088670&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10385642 103987547 CHEMBL11766 ZINC26024080 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730409 Clc1c2C(=O)N(CCCCCCc3ccccc3)C(=O)c2c(Cl)c(Cl)c1Cl InChI=1S/C20H17Cl4NO2/c21-15-13-14(16(22)18(24)17(15)23)20(27)25(19(13)26)11-7-2-1-4-8-12-9-5-3-6-10-12/h3,5-6,9-10H,1-2,4,7-8,11H2 JDROLWMPHLZOJX-UHFFFAOYSA-N 50088672 4,5,6,7-Tetrachloro-2-(6-phenyl-hexyl)-isoindole-1,3-dione::CHEMBL275509 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088672&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44267363 103987549 CHEMBL275509 ZINC26022384 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730411 [O-][N+](=O)c1cccc2C(=O)N(C(=O)c12)c1ccccc1 InChI=1S/C14H8N2O4/c17-13-10-7-4-8-11(16(19)20)12(10)14(18)15(13)9-5-2-1-3-6-9/h1-8H OMOHDUGKQSTKSR-UHFFFAOYSA-N 50088682 4-Nitro-2-phenyl-isoindole-1,3-dione::CHEMBL11614::cid_272783 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088682&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 272783 103987559 CHEMBL11614 ZINC00262369 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50730415 Clc1c2C(=O)N(CCCCCc3ccccc3)C(=O)c2c(Cl)c(Cl)c1Cl InChI=1S/C19H15Cl4NO2/c20-14-12-13(15(21)17(23)16(14)22)19(26)24(18(12)25)10-6-2-5-9-11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9-10H2 WGJQRZJWAYSTCK-UHFFFAOYSA-N 50088683 4,5,6,7-Tetrachloro-2-(5-phenyl-pentyl)-isoindole-1,3-dione::4,5,6,7-tetrachloro-2-(5-phenylpentyl)isoindoline-1,3-dione::CHEMBL276643 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1016/s0960-894x(00)00161-x 10.7270/Q25D8SCS 10843222 Sou, S; Mayumi, S; Takahashi, H; Yamasaki, R; Kadoya, S; Sodeoka, M; Hashimoto, Y University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088683&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10788794 103987560 CHEMBL276643 ZINC26023848 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50724274 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 LXBIFEVIBLOUGU-JGWLITMVSA-N 18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US9181184, 1::dNM Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DNJ 1DIE,1DOG,1I75,1OIM,2J77,2JKE,2PWD,3GBE,3GXT 29435 46518429 44369 CHEMBL307429 4642 C16843 ZINC03794714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50724299 OCC1(O)C(O)C(O)C2(CO)OCC(Nc3ccccc3)=NC12 InChI=1S/C15H20N2O6/c18-7-14(22)11(20)12(21)15(8-19)13(14)17-10(6-23-15)16-9-4-2-1-3-5-9/h1-5,11-13,18-22H,6-8H2,(H,16,17) VCQTVMUCIZQHEV-UHFFFAOYSA-N 50283599 5,7a-Bis-hydroxymethyl-3-phenylamino-2,4a,5,6,7,7a-hexahydro-cyclopenta[1,4]oxazine-5,6,7-triol::CHEMBL314403 Lysosomal acid glucosylceramidase Homo sapiens 211000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283599&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44322883 104125256 CHEMBL314403 ZINC40689069 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50722941 C[C@H]1OC[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C6H12O4/c1-3-5(8)6(9)4(7)2-10-3/h3-9H,2H2,1H3/t3-,4+,5+,6-/m1/s1 KBVSUNBCTPQWJL-DPYQTVNSSA-N 50279838 (2R,3R,4R,5S)-2-Methyl-tetrahydro-pyran-3,4,5-triol::CHEMBL346964 Lysosomal acid glucosylceramidase Homo sapiens 42000000 ChEMBL 10.1016/S0960-894X(01)81044-1 10.7270/Q26W9BKM Field, RA; Haines, AH; Chrystal, EJ TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279838&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search FCA 1H86,1H84,1H83,1H82,1H81,7ABP,2HCZ,3CAH,1B5Q,1APB,1J86,1B37,6DB6,5KZW,5KZX,4DWC,3N31,1EX1,1ABF 11744779 104121542 CHEMBL346964 ZINC15284661 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544568 O[C@@H]1CNC2(CC2)[C@H](C=C)[C@H]1O InChI=1S/C9H15NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h2,6-8,10-12H,1,3-5H2/t6-,7-,8-/m1/s1 JNIYJHDOBMNALK-BWZBUEFSSA-N 285834 (6R,7R,8S)-8-vinyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 16::US9796680, Example 16 Lysosomal acid glucosylceramidase Homo sapiens 7.60 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285834&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197774 378169471 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50872859 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 LXBIFEVIBLOUGU-JGWLITMVSA-N 18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US9181184, 1::dNM Lysosomal acid glucosylceramidase Homo sapiens 240000 ChEMBL 10.1016/j.bmc.2008.06.026 10.7270/Q27D2W2B 18595718 Kuriyama, C; Kamiyama, O; Ikeda, K; Sanae, F; Kato, A; Adachi, I; Imahori, T; Takahata, H; Okamoto, T; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DNJ 1DIE,1DOG,1I75,1OIM,2J77,2JKE,2PWD,3GBE,3GXT 29435 46518429 44369 CHEMBL307429 4642 C16843 ZINC03794714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50872860 OC[C@@H]1CNC[C@H](O)[C@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m0/s1 QPYJXFZUIJOGNX-ZLUOBGJFSA-N 50263043 CHEMBL501385::L-Isofagomine Lysosomal acid glucosylceramidase Homo sapiens 9000 ChEMBL 10.1016/j.bmc.2008.06.026 10.7270/Q27D2W2B 18595718 Kuriyama, C; Kamiyama, O; Ikeda, K; Sanae, F; Kato, A; Adachi, I; Imahori, T; Takahata, H; Okamoto, T; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263043&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44578588 104111538 CHEMBL501385 ZINC01484929 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50872861 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 60 ChEMBL 10.1016/j.bmc.2008.06.026 10.7270/Q27D2W2B 18595718 Kuriyama, C; Kamiyama, O; Ikeda, K; Sanae, F; Kato, A; Adachi, I; Imahori, T; Takahata, H; Okamoto, T; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50872862 O[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ RMCNETIHECSPMZ-SCDXWVJYSA-N 50182798 (3R,4r,5S)-piperidine-3,4,5-triol::1,5-Dideoxy-1,5-imino-D-xylitol::CHEMBL110830::PIPERIDINE-3,4,5-TRIOL Lysosomal acid glucosylceramidase Homo sapiens 2300 ChEMBL 10.1016/j.bmc.2008.06.026 10.7270/Q27D2W2B 18595718 Kuriyama, C; Kamiyama, O; Ikeda, K; Sanae, F; Kato, A; Adachi, I; Imahori, T; Takahata, H; Okamoto, T; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182798&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search XDN 1V0K,1FH7,1V0M 445612 104067413 CHEMBL110830 ZINC14658010 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50872863 OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1 IBAQFPQHRJAVAV-ULAWRXDQSA-N 50242271 (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol::(2R,3R,4R,5S)-1-ethoxy-2-(hydroxymethyl)piperidine-3,4,5-triol::BAY-M-1099::CHEMBL1561::Glyset::MIGLITOL::N-Hydroxyethyl-1-deoxynojirimycin::cid_441314 Lysosomal acid glucosylceramidase Homo sapiens 84000 ChEMBL 10.1016/j.bmc.2008.06.026 10.7270/Q27D2W2B 18595718 Kuriyama, C; Kamiyama, O; Ikeda, K; Sanae, F; Kato, A; Adachi, I; Imahori, T; Takahata, H; Okamoto, T; Asano, N Hokuriku University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242271&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search MIG 3L4W,6CA3,6CA1,5NN6 441314 104099012 CHEMBL1561 DB00491 4842 C07708 ZINC04097426 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913049 CCCCCCCCCCCn1cc(CCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C21H40N4O5/c1-2-3-4-5-6-7-8-9-10-13-25-14-15(23-24-25)11-12-22-16-17(26)19(28)21(30)20(29)18(16)27/h14,16-22,26-30H,2-13H2,1H3/t16-,17-,18+,19+,20-,21- HDMAMPJZZMETIV-XLGNRPJKSA-N 50318555 (1R,2S,3r,4R,5S,6s)-6-[2-(1-Undecyl-1H-1,2,3-triazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085633 Lysosomal acid glucosylceramidase Homo sapiens 4900 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318555&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867664 104152916 CHEMBL1085633 ZINC49793634 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913050 CCCCCCCCCCn1cc(CCCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C21H40N4O5/c1-2-3-4-5-6-7-8-9-13-25-14-15(23-24-25)11-10-12-22-16-17(26)19(28)21(30)20(29)18(16)27/h14,16-22,26-30H,2-13H2,1H3/t16-,17-,18+,19+,20-,21- WESSLVVPBLSCJX-XLGNRPJKSA-N 50318557 (1R,2S,3r,4R,5S,6s)-6-(3-(1-decyl-1H-1,2,3-triazol-4-yl)propylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1083794 Lysosomal acid glucosylceramidase Homo sapiens 3500 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318557&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867950 104152918 CHEMBL1083794 ZINC49777055 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913051 CCCOCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C18H34N4O6/c1-2-8-28-9-6-4-3-5-7-22-11-12(20-21-22)10-19-13-14(23)16(25)18(27)17(26)15(13)24/h11,13-19,23-27H,2-10H2,1H3/t13-,14-,15+,16+,17-,18- FLUOEQUIGPEGGG-WKTMMLQWSA-N 50318558 (1R,2S,3r,4R,5S,6s)-6-((1-(6-propoxyhexyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1086533 Lysosomal acid glucosylceramidase Homo sapiens 2400 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318558&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867532 104152919 CHEMBL1086533 ZINC49049727 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913052 CCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C17H32N4O5/c1-2-3-4-5-6-7-8-21-10-11(19-20-21)9-18-12-13(22)15(24)17(26)16(25)14(12)23/h10,12-18,22-26H,2-9H2,1H3/t12-,13-,14+,15+,16-,17- GOWXONIFDQHALJ-ZDVFKUJDSA-N 50318559 (1R,2S,3r,4R,5S,6s)-6-[(1-Octyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085392 Lysosomal acid glucosylceramidase Homo sapiens 1800 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318559&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867661 104152920 CHEMBL1085392 ZINC49777326 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913053 CCCCCCCCCCN[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C16H33NO5/c1-2-3-4-5-6-7-8-9-10-17-11-12(18)14(20)16(22)15(21)13(11)19/h11-22H,2-10H2,1H3/t11-,12-,13+,14+,15-,16- VRJPTDKBAXVMJT-KUNQJQEJSA-N 50318560 CHEMBL1083795::N-decylaminocyclitol Lysosomal acid glucosylceramidase Homo sapiens 1800 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318560&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46889930 104152921 CHEMBL1083795 ZINC49777251 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913054 CCCCCCCCCCn1cc(CCCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C21H40N4O5/c1-2-3-4-5-6-7-8-9-13-25-14-15(23-24-25)11-10-12-22-16-17(26)19(28)21(30)20(29)18(16)27/h14,16-22,26-30H,2-13H2,1H3/t16-,17-,18+,19+,20-,21- WESSLVVPBLSCJX-XLGNRPJKSA-N 50318557 (1R,2S,3r,4R,5S,6s)-6-(3-(1-decyl-1H-1,2,3-triazol-4-yl)propylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1083794 Lysosomal acid glucosylceramidase Homo sapiens 1200 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318557&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867950 104152918 CHEMBL1083794 ZINC49777055 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913055 CCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C17H32N4O5/c1-2-3-4-5-6-7-8-21-10-11(19-20-21)9-18-12-13(22)15(24)17(26)16(25)14(12)23/h10,12-18,22-26H,2-9H2,1H3/t12-,13-,14+,15+,16-,17- GOWXONIFDQHALJ-ZDVFKUJDSA-N 50318559 (1R,2S,3r,4R,5S,6s)-6-[(1-Octyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085392 Lysosomal acid glucosylceramidase Homo sapiens 1100 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318559&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867661 104152920 CHEMBL1085392 ZINC49777326 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913056 CCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C17H32N4O5/c1-2-3-4-5-6-7-8-21-10-11(19-20-21)9-18-12-13(22)15(24)17(26)16(25)14(12)23/h10,12-18,22-26H,2-9H2,1H3/t12-,13-,14+,15+,16-,17- GOWXONIFDQHALJ-ZDVFKUJDSA-N 50318559 (1R,2S,3r,4R,5S,6s)-6-[(1-Octyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085392 Lysosomal acid glucosylceramidase Homo sapiens 1000 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318559&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867661 104152920 CHEMBL1085392 ZINC49777326 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913057 CCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C18H34N4O5/c1-2-3-4-5-6-7-8-9-22-11-12(20-21-22)10-19-13-14(23)16(25)18(27)17(26)15(13)24/h11,13-19,23-27H,2-10H2,1H3/t13-,14-,15+,16+,17-,18- HXLITFAGQOAVKE-WKTMMLQWSA-N 50318561 (1R,2S,3r,4R,5S,6s)-6-[(1-Nonyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085393 Lysosomal acid glucosylceramidase Homo sapiens 330 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318561&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867528 104152922 CHEMBL1085393 ZINC49777327 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913058 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 300 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913059 CCCCCCCCCCN[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C16H33NO5/c1-2-3-4-5-6-7-8-9-10-17-11-12(18)14(20)16(22)15(21)13(11)19/h11-22H,2-10H2,1H3/t11-,12-,13+,14+,15-,16- VRJPTDKBAXVMJT-KUNQJQEJSA-N 50318560 CHEMBL1083795::N-decylaminocyclitol Lysosomal acid glucosylceramidase Homo sapiens 300 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318560&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46889930 104152921 CHEMBL1083795 ZINC49777251 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913060 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 300 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913061 CCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C18H34N4O5/c1-2-3-4-5-6-7-8-9-22-11-12(20-21-22)10-19-13-14(23)16(25)18(27)17(26)15(13)24/h11,13-19,23-27H,2-10H2,1H3/t13-,14-,15+,16+,17-,18- HXLITFAGQOAVKE-WKTMMLQWSA-N 50318561 (1R,2S,3r,4R,5S,6s)-6-[(1-Nonyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085393 Lysosomal acid glucosylceramidase Homo sapiens 200 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318561&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867528 104152922 CHEMBL1085393 ZINC49777327 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913062 CCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C18H34N4O5/c1-2-3-4-5-6-7-8-9-22-11-12(20-21-22)10-19-13-14(23)16(25)18(27)17(26)15(13)24/h11,13-19,23-27H,2-10H2,1H3/t13-,14-,15+,16+,17-,18- HXLITFAGQOAVKE-WKTMMLQWSA-N 50318561 (1R,2S,3r,4R,5S,6s)-6-[(1-Nonyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085393 Lysosomal acid glucosylceramidase Homo sapiens 200 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318561&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867528 104152922 CHEMBL1085393 ZINC49777327 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913063 CCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O5/c1-2-3-4-5-6-7-8-9-10-23-12-13(21-22-23)11-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- DCJWZIGHKBTFDW-OXHPVDPFSA-N 50318562 (1R,2S,3r,4R,5S,6s)-6-[(1-Decyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1082596 Lysosomal acid glucosylceramidase Homo sapiens 100 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318562&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867529 104152923 CHEMBL1082596 ZINC49777498 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913064 CCCCCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C23H44N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-27-16-17(25-26-27)15-24-18-19(28)21(30)23(32)22(31)20(18)29/h16,18-24,28-32H,2-15H2,1H3/t18-,19-,20+,21+,22-,23- NQJWAXBXRCRIRR-FPDSAVIVSA-N 50318563 (1R,2S,3r,4R,5S,6s)-6-[(1-Tetradecyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1086532 Lysosomal acid glucosylceramidase Homo sapiens 100 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318563&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867531 104152924 CHEMBL1086532 ZINC49777660 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913065 CCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O5/c1-2-3-4-5-6-7-8-9-10-23-12-13(21-22-23)11-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- DCJWZIGHKBTFDW-OXHPVDPFSA-N 50318562 (1R,2S,3r,4R,5S,6s)-6-[(1-Decyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1082596 Lysosomal acid glucosylceramidase Homo sapiens 90 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318562&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867529 104152923 CHEMBL1082596 ZINC49777498 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913066 CCCCCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C23H44N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-27-16-17(25-26-27)15-24-18-19(28)21(30)23(32)22(31)20(18)29/h16,18-24,28-32H,2-15H2,1H3/t18-,19-,20+,21+,22-,23- NQJWAXBXRCRIRR-FPDSAVIVSA-N 50318563 (1R,2S,3r,4R,5S,6s)-6-[(1-Tetradecyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1086532 Lysosomal acid glucosylceramidase Homo sapiens 90 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318563&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867531 104152924 CHEMBL1086532 ZINC49777660 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913067 CCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O5/c1-2-3-4-5-6-7-8-9-10-23-12-13(21-22-23)11-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- DCJWZIGHKBTFDW-OXHPVDPFSA-N 50318562 (1R,2S,3r,4R,5S,6s)-6-[(1-Decyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1082596 Lysosomal acid glucosylceramidase Homo sapiens 90 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318562&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867529 104152923 CHEMBL1082596 ZINC49777498 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913068 CCCCCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C23H44N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-27-16-17(25-26-27)15-24-18-19(28)21(30)23(32)22(31)20(18)29/h16,18-24,28-32H,2-15H2,1H3/t18-,19-,20+,21+,22-,23- NQJWAXBXRCRIRR-FPDSAVIVSA-N 50318563 (1R,2S,3r,4R,5S,6s)-6-[(1-Tetradecyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1086532 Lysosomal acid glucosylceramidase Homo sapiens 80 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318563&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867531 104152924 CHEMBL1086532 ZINC49777660 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913069 CCCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C21H40N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-25-14-15(23-24-25)13-22-16-17(26)19(28)21(30)20(29)18(16)27/h14,16-22,26-30H,2-13H2,1H3/t16-,17-,18+,19+,20-,21- BNEBWGRZFSZRAG-XLGNRPJKSA-N 50318564 (1R,2S,3r,4R,5S,6s)-6-((1-dodecyl-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1084109 Lysosomal acid glucosylceramidase Homo sapiens 60 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318564&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867530 104152925 CHEMBL1084109 ZINC49775755 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913070 CCCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C21H40N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-25-14-15(23-24-25)13-22-16-17(26)19(28)21(30)20(29)18(16)27/h14,16-22,26-30H,2-13H2,1H3/t16-,17-,18+,19+,20-,21- BNEBWGRZFSZRAG-XLGNRPJKSA-N 50318564 (1R,2S,3r,4R,5S,6s)-6-((1-dodecyl-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1084109 Lysosomal acid glucosylceramidase Homo sapiens 60 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318564&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867530 104152925 CHEMBL1084109 ZINC49775755 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913071 CCCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C21H40N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-25-14-15(23-24-25)13-22-16-17(26)19(28)21(30)20(29)18(16)27/h14,16-22,26-30H,2-13H2,1H3/t16-,17-,18+,19+,20-,21- BNEBWGRZFSZRAG-XLGNRPJKSA-N 50318564 (1R,2S,3r,4R,5S,6s)-6-((1-dodecyl-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1084109 Lysosomal acid glucosylceramidase Homo sapiens 30 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318564&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867530 104152925 CHEMBL1084109 ZINC49775755 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913072 CCCCCCn1cc(CCCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C17H32N4O5/c1-2-3-4-5-9-21-10-11(19-20-21)7-6-8-18-12-13(22)15(24)17(26)16(25)14(12)23/h10,12-18,22-26H,2-9H2,1H3/t12-,13-,14+,15+,16-,17- SPFGFLKJRLUZKI-ZDVFKUJDSA-N 50318550 (1R,2S,3r,4R,5S,6s)-6-(3-(1-hexyl-1H-1,2,3-triazol-4-yl)propylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085859 Lysosomal acid glucosylceramidase Homo sapiens 257000 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318550&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867665 104152911 CHEMBL1085859 ZINC49048734 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913073 CCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C13H24N4O5/c1-2-3-4-17-6-7(15-16-17)5-14-8-9(18)11(20)13(22)12(21)10(8)19/h6,8-14,18-22H,2-5H2,1H3/t8-,9-,10+,11+,12-,13- NQRJFRVZMYWOAY-XESFAPMISA-N 50318551 (1R,2S,3r,4R,5S,6s)-6-[(1-Butyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085391 Lysosomal acid glucosylceramidase Homo sapiens 178000 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318551&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867403 104152912 CHEMBL1085391 ZINC49109651 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913074 CCCCCCCCn1cc(CCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C18H34N4O5/c1-2-3-4-5-6-7-10-22-11-12(20-21-22)8-9-19-13-14(23)16(25)18(27)17(26)15(13)24/h11,13-19,23-27H,2-10H2,1H3/t13-,14-,15+,16+,17-,18- DDVJOAOFJIEZRH-WKTMMLQWSA-N 50318552 (1R,2S,3r,4R,5S,6s)-6-[2-(1-Octyl-1H-1,2,3-triazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085631 Lysosomal acid glucosylceramidase Homo sapiens 167000 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318552&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867662 104152913 CHEMBL1085631 ZINC49777202 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913075 CCCCCCCCn1cc(CCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C18H34N4O5/c1-2-3-4-5-6-7-10-22-11-12(20-21-22)8-9-19-13-14(23)16(25)18(27)17(26)15(13)24/h11,13-19,23-27H,2-10H2,1H3/t13-,14-,15+,16+,17-,18- DDVJOAOFJIEZRH-WKTMMLQWSA-N 50318552 (1R,2S,3r,4R,5S,6s)-6-[2-(1-Octyl-1H-1,2,3-triazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085631 Lysosomal acid glucosylceramidase Homo sapiens 55900 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318552&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867662 104152913 CHEMBL1085631 ZINC49777202 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913076 CCCCCCCCCn1cc(CCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O5/c1-2-3-4-5-6-7-8-11-23-12-13(21-22-23)9-10-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- GJHJPNQJJDDGMK-OXHPVDPFSA-N 50318553 (1R,2S,3r,4R,5S,6s)-6-[2-(1-Nonyl-1H-1,2,3-triazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085632 Lysosomal acid glucosylceramidase Homo sapiens 44700 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318553&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867663 104152914 CHEMBL1085632 ZINC49777203 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913077 CCCCCCn1cc(CCCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C17H32N4O5/c1-2-3-4-5-9-21-10-11(19-20-21)7-6-8-18-12-13(22)15(24)17(26)16(25)14(12)23/h10,12-18,22-26H,2-9H2,1H3/t12-,13-,14+,15+,16-,17- SPFGFLKJRLUZKI-ZDVFKUJDSA-N 50318550 (1R,2S,3r,4R,5S,6s)-6-(3-(1-hexyl-1H-1,2,3-triazol-4-yl)propylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085859 Lysosomal acid glucosylceramidase Homo sapiens 44600 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318550&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867665 104152911 CHEMBL1085859 ZINC49048734 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913078 CCCCCCCCn1cc(CCCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O5/c1-2-3-4-5-6-7-11-23-12-13(21-22-23)9-8-10-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- WNRYFPGBHSMMSQ-OXHPVDPFSA-N 50318554 (1R,2S,3r,4R,5S,6s)-6-(3-(1-octyl-1H-1,2,3-triazol-4-yl)propylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085130 Lysosomal acid glucosylceramidase Homo sapiens 35400 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318554&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867666 104152915 CHEMBL1085130 ZINC49793241 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913079 CCCCCCCCCCCn1cc(CCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C21H40N4O5/c1-2-3-4-5-6-7-8-9-10-13-25-14-15(23-24-25)11-12-22-16-17(26)19(28)21(30)20(29)18(16)27/h14,16-22,26-30H,2-13H2,1H3/t16-,17-,18+,19+,20-,21- HDMAMPJZZMETIV-XLGNRPJKSA-N 50318555 (1R,2S,3r,4R,5S,6s)-6-[2-(1-Undecyl-1H-1,2,3-triazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085633 Lysosomal acid glucosylceramidase Homo sapiens 25400 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318555&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867664 104152916 CHEMBL1085633 ZINC49793634 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913080 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCc3ccccc3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C17H24N4O5/c22-13-12(14(23)16(25)17(26)15(13)24)18-8-11-9-21(20-19-11)7-6-10-4-2-1-3-5-10/h1-5,9,12-18,22-26H,6-8H2/t12-,13-,14+,15+,16-,17- YAYXNORBGXQXFG-ZDVFKUJDSA-N 50318556 (1R,2S,3r,4R,5S,6s)-6-[(1-Phenethyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1082491 Lysosomal acid glucosylceramidase Homo sapiens 25000 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318556&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867533 104152917 CHEMBL1082491 ZINC49034581 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913081 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 660 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913082 CCCCCCCCCCCn1cc(CCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C21H40N4O5/c1-2-3-4-5-6-7-8-9-10-13-25-14-15(23-24-25)11-12-22-16-17(26)19(28)21(30)20(29)18(16)27/h14,16-22,26-30H,2-13H2,1H3/t16-,17-,18+,19+,20-,21- HDMAMPJZZMETIV-XLGNRPJKSA-N 50318555 (1R,2S,3r,4R,5S,6s)-6-[2-(1-Undecyl-1H-1,2,3-triazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085633 Lysosomal acid glucosylceramidase Homo sapiens 20200 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318555&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867664 104152916 CHEMBL1085633 ZINC49793634 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913083 CCCCCCCCn1cc(CCCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O5/c1-2-3-4-5-6-7-11-23-12-13(21-22-23)9-8-10-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- WNRYFPGBHSMMSQ-OXHPVDPFSA-N 50318554 (1R,2S,3r,4R,5S,6s)-6-(3-(1-octyl-1H-1,2,3-triazol-4-yl)propylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085130 Lysosomal acid glucosylceramidase Homo sapiens 19900 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318554&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867666 104152915 CHEMBL1085130 ZINC49793241 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913084 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCc3ccccc3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C17H24N4O5/c22-13-12(14(23)16(25)17(26)15(13)24)18-8-11-9-21(20-19-11)7-6-10-4-2-1-3-5-10/h1-5,9,12-18,22-26H,6-8H2/t12-,13-,14+,15+,16-,17- YAYXNORBGXQXFG-ZDVFKUJDSA-N 50318556 (1R,2S,3r,4R,5S,6s)-6-[(1-Phenethyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1082491 Lysosomal acid glucosylceramidase Homo sapiens 19100 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318556&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867533 104152917 CHEMBL1082491 ZINC49034581 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913085 CCCCCCCCn1cc(CCCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O5/c1-2-3-4-5-6-7-11-23-12-13(21-22-23)9-8-10-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- WNRYFPGBHSMMSQ-OXHPVDPFSA-N 50318554 (1R,2S,3r,4R,5S,6s)-6-(3-(1-octyl-1H-1,2,3-triazol-4-yl)propylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085130 Lysosomal acid glucosylceramidase Homo sapiens 18200 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318554&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867666 104152915 CHEMBL1085130 ZINC49793241 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913086 CCCCCCCCCn1cc(CCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O5/c1-2-3-4-5-6-7-8-11-23-12-13(21-22-23)9-10-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- GJHJPNQJJDDGMK-OXHPVDPFSA-N 50318553 (1R,2S,3r,4R,5S,6s)-6-[2-(1-Nonyl-1H-1,2,3-triazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085632 Lysosomal acid glucosylceramidase Homo sapiens 11000 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318553&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867663 104152914 CHEMBL1085632 ZINC49777203 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913087 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCc3ccccc3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C17H24N4O5/c22-13-12(14(23)16(25)17(26)15(13)24)18-8-11-9-21(20-19-11)7-6-10-4-2-1-3-5-10/h1-5,9,12-18,22-26H,6-8H2/t12-,13-,14+,15+,16-,17- YAYXNORBGXQXFG-ZDVFKUJDSA-N 50318556 (1R,2S,3r,4R,5S,6s)-6-[(1-Phenethyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1082491 Lysosomal acid glucosylceramidase Homo sapiens 10800 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318556&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867533 104152917 CHEMBL1082491 ZINC49034581 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913088 CCCCCCCCCCn1cc(CCCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C21H40N4O5/c1-2-3-4-5-6-7-8-9-13-25-14-15(23-24-25)11-10-12-22-16-17(26)19(28)21(30)20(29)18(16)27/h14,16-22,26-30H,2-13H2,1H3/t16-,17-,18+,19+,20-,21- WESSLVVPBLSCJX-XLGNRPJKSA-N 50318557 (1R,2S,3r,4R,5S,6s)-6-(3-(1-decyl-1H-1,2,3-triazol-4-yl)propylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1083794 Lysosomal acid glucosylceramidase Homo sapiens 7600 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318557&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867950 104152918 CHEMBL1083794 ZINC49777055 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913089 CCCOCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C18H34N4O6/c1-2-8-28-9-6-4-3-5-7-22-11-12(20-21-22)10-19-13-14(23)16(25)18(27)17(26)15(13)24/h11,13-19,23-27H,2-10H2,1H3/t13-,14-,15+,16+,17-,18- FLUOEQUIGPEGGG-WKTMMLQWSA-N 50318558 (1R,2S,3r,4R,5S,6s)-6-((1-(6-propoxyhexyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1086533 Lysosomal acid glucosylceramidase Homo sapiens 7400 5.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318558&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867532 104152919 CHEMBL1086533 ZINC49049727 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50913090 CCCOCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C18H34N4O6/c1-2-8-28-9-6-4-3-5-7-22-11-12(20-21-22)10-19-13-14(23)16(25)18(27)17(26)15(13)24/h11,13-19,23-27H,2-10H2,1H3/t13-,14-,15+,16+,17-,18- FLUOEQUIGPEGGG-WKTMMLQWSA-N 50318558 (1R,2S,3r,4R,5S,6s)-6-((1-(6-propoxyhexyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1086533 Lysosomal acid glucosylceramidase Homo sapiens 6200 7.4 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318558&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867532 104152919 CHEMBL1086533 ZINC49049727 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934423 CC(C)SCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C10H21NO3S/c1-6(2)15-4-3-7-9(13)10(14)8(12)5-11-7/h6-14H,3-5H2,1-2H3/t7-,8-,9+,10+/m1/s1 OBXCPOAUASMRSK-IMSYWVGJSA-N 50383314 CHEMBL2029774 Lysosomal acid glucosylceramidase Homo sapiens 76 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383314&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341118 160862397 CHEMBL2029774 ZINC84652672 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934425 O[C@@H]1CN[C@H](CCSCCCC(=O)N2CCOCC2)[C@H](O)[C@H]1O InChI=1S/C15H28N2O5S/c18-12-10-16-11(14(20)15(12)21)3-9-23-8-1-2-13(19)17-4-6-22-7-5-17/h11-12,14-16,18,20-21H,1-10H2/t11-,12-,14+,15+/m1/s1 XPCYBGWWHFUSLQ-UXOAXIEHSA-N 50383316 CHEMBL2029785 Lysosomal acid glucosylceramidase Homo sapiens 450 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383316&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341105 160862399 CHEMBL2029785 ZINC84740933 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934426 CCN(CC)C(=O)CCCSCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H30N2O4S/c1-3-17(4-2)13(19)6-5-8-22-9-7-11-14(20)15(21)12(18)10-16-11/h11-12,14-16,18,20-21H,3-10H2,1-2H3/t11-,12-,14+,15+/m1/s1 QYWWGYAMBGMLKP-UXOAXIEHSA-N 50383317 CHEMBL2029784 Lysosomal acid glucosylceramidase Homo sapiens 250 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383317&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341493 160862400 CHEMBL2029784 ZINC84671221 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934427 O[C@@H]1CN[C@H](CCSCC(=O)NCc2ccccc2)[C@H](O)[C@H]1O InChI=1S/C16H24N2O4S/c19-13-9-17-12(15(21)16(13)22)6-7-23-10-14(20)18-8-11-4-2-1-3-5-11/h1-5,12-13,15-17,19,21-22H,6-10H2,(H,18,20)/t12-,13-,15+,16+/m1/s1 FFXWOHFMEBTOFU-VDERGJSUSA-N 50383318 CHEMBL2029783 Lysosomal acid glucosylceramidase Homo sapiens 30 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383318&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341315 160862401 CHEMBL2029783 ZINC84687648 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934428 O[C@@H]1CN[C@H](CCSCCNC(=O)Nc2ccccc2)[C@H](O)[C@H]1O InChI=1S/C16H25N3O4S/c20-13-10-18-12(14(21)15(13)22)6-8-24-9-7-17-16(23)19-11-4-2-1-3-5-11/h1-5,12-15,18,20-22H,6-10H2,(H2,17,19,23)/t12-,13-,14+,15+/m1/s1 JSCAOTSHQFRXCZ-KBXIAJHMSA-N 50383319 CHEMBL2029782 Lysosomal acid glucosylceramidase Homo sapiens 12 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383319&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341313 160862402 CHEMBL2029782 ZINC84652866 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934429 CCCC(=O)NCCSCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C13H26N2O4S/c1-2-3-11(17)14-5-7-20-6-4-9-12(18)13(19)10(16)8-15-9/h9-10,12-13,15-16,18-19H,2-8H2,1H3,(H,14,17)/t9-,10-,12+,13+/m1/s1 MEIROJRVZLYBNR-AAXDQBDMSA-N 50383320 CHEMBL2029781 Lysosomal acid glucosylceramidase Homo sapiens 200 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383320&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341311 160862403 CHEMBL2029781 ZINC84732927 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934430 O[C@@H]1CN[C@H](CCSCCc2ccccc2)[C@H](O)[C@H]1O InChI=1S/C15H23NO3S/c17-13-10-16-12(14(18)15(13)19)7-9-20-8-6-11-4-2-1-3-5-11/h1-5,12-19H,6-10H2/t12-,13-,14+,15+/m1/s1 DRTZJXVKUAQCDX-KBXIAJHMSA-N 50383321 CHEMBL2029780 Lysosomal acid glucosylceramidase Homo sapiens 3 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383321&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341309 160862404 CHEMBL2029780 ZINC84731934 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934431 O[C@@H]1CN[C@H](CCSCc2ccccc2)[C@H](O)[C@H]1O InChI=1S/C14H21NO3S/c16-12-8-15-11(13(17)14(12)18)6-7-19-9-10-4-2-1-3-5-10/h1-5,11-18H,6-9H2/t11-,12-,13+,14+/m1/s1 UMFLVFDRLSSIHM-MQYQWHSLSA-N 50383322 CHEMBL2029779 Lysosomal acid glucosylceramidase Homo sapiens 19 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383322&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341307 160862405 CHEMBL2029779 ZINC84731743 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934432 O[C@@H]1CN[C@H](CCSC2CCCCC2)[C@H](O)[C@H]1O InChI=1S/C13H25NO3S/c15-11-8-14-10(12(16)13(11)17)6-7-18-9-4-2-1-3-5-9/h9-17H,1-8H2/t10-,11-,12+,13+/m1/s1 JTPGQSQEPALNOF-NDBYEHHHSA-N 50383323 CHEMBL2029778 Lysosomal acid glucosylceramidase Homo sapiens 4 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383323&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341305 160862406 CHEMBL2029778 ZINC84652661 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934433 O[C@@H]1CN[C@H](CCSC2CCCC2)[C@H](O)[C@H]1O InChI=1S/C12H23NO3S/c14-10-7-13-9(11(15)12(10)16)5-6-17-8-3-1-2-4-8/h8-16H,1-7H2/t9-,10-,11+,12+/m1/s1 CIANZELPEJCTIX-WYUUTHIRSA-N 50383324 CHEMBL2029777 Lysosomal acid glucosylceramidase Homo sapiens 6 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383324&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341303 160862407 CHEMBL2029777 ZINC84731746 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934434 CC(C)CCSCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C12H25NO3S/c1-8(2)3-5-17-6-4-9-11(15)12(16)10(14)7-13-9/h8-16H,3-7H2,1-2H3/t9-,10-,11+,12+/m1/s1 VHDOPSHUIBFVME-WYUUTHIRSA-N 50383325 CHEMBL2029776 Lysosomal acid glucosylceramidase Homo sapiens 4.4 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383325&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341301 160862408 CHEMBL2029776 ZINC84740274 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934435 CC(C)(C)SCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C11H23NO3S/c1-11(2,3)16-5-4-7-9(14)10(15)8(13)6-12-7/h7-10,12-15H,4-6H2,1-3H3/t7-,8-,9+,10+/m1/s1 CNBLYVDBIFJWSJ-IMSYWVGJSA-N 50383326 CHEMBL2029775 Lysosomal acid glucosylceramidase Homo sapiens 29 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383326&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341120 160862409 CHEMBL2029775 ZINC84671279 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934436 CCCCCCCCSCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO3S/c1-2-3-4-5-6-7-9-20-10-8-12-14(18)15(19)13(17)11-16-12/h12-19H,2-11H2,1H3/t12-,13-,14+,15+/m1/s1 SHDFSZYRVCBUSH-KBXIAJHMSA-N 50383315 CHEMBL2029773 Lysosomal acid glucosylceramidase Homo sapiens 0.4 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383315&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341116 160862398 CHEMBL2029773 ZINC84668759 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934437 CCCCCCSCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C13H27NO3S/c1-2-3-4-5-7-18-8-6-10-12(16)13(17)11(15)9-14-10/h10-17H,2-9H2,1H3/t10-,11-,12+,13+/m1/s1 IQBVMIFZGTVLIH-NDBYEHHHSA-N 50383327 CHEMBL2029772 Lysosomal acid glucosylceramidase Homo sapiens 1.8 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383327&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341114 160862410 CHEMBL2029772 ZINC84671208 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934438 CCCCSCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C11H23NO3S/c1-2-3-5-16-6-4-8-10(14)11(15)9(13)7-12-8/h8-15H,2-7H2,1H3/t8-,9-,10+,11+/m1/s1 XNFZUXIQHILACT-ZNSHCXBVSA-N 50383328 CHEMBL2029771 Lysosomal acid glucosylceramidase Homo sapiens 18 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383328&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341112 160862411 CHEMBL2029771 ZINC84652311 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934439 CCSCC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C9H19NO3S/c1-2-14-4-3-6-8(12)9(13)7(11)5-10-6/h6-13H,2-5H2,1H3/t6-,7-,8+,9+/m1/s1 QYTGIBXRLUXTHV-HXFLIBJXSA-N 50383329 CHEMBL2029770 Lysosomal acid glucosylceramidase Homo sapiens 180 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383329&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341110 160862412 CHEMBL2029770 ZINC84652830 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934440 CC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C7H15NO3/c1-2-4-6(10)7(11)5(9)3-8-4/h4-11H,2-3H2,1H3/t4-,5-,6+,7+/m1/s1 KNOLQTVRSJRSAM-JWXFUTCRSA-N 50383330 CHEMBL2029769 Lysosomal acid glucosylceramidase Homo sapiens 1100 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383330&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 14752275 160862413 CHEMBL2029769 ZINC84652836 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934441 O[C@@H]1CN[C@H](C=C)[C@H](O)[C@H]1O InChI=1S/C7H13NO3/c1-2-4-6(10)7(11)5(9)3-8-4/h2,4-11H,1,3H2/t4-,5-,6+,7+/m1/s1 XUWJGWVDBHLQOD-JWXFUTCRSA-N 50383331 CHEMBL2029768 Lysosomal acid glucosylceramidase Homo sapiens 2700 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50383331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50383331&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57341107 160862414 CHEMBL2029768 ZINC84668758 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50934442 O[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ RMCNETIHECSPMZ-SCDXWVJYSA-N 50182798 (3R,4r,5S)-piperidine-3,4,5-triol::1,5-Dideoxy-1,5-imino-D-xylitol::CHEMBL110830::PIPERIDINE-3,4,5-TRIOL Lysosomal acid glucosylceramidase Homo sapiens 2800 5 ChEMBL 10.1021/jm201633y 10.7270/Q2639QSX 22360565 Goddard-Borger, ED; Tropak, MB; Yonekawa, S; Tysoe, C; Mahuran, DJ; Withers, SG University of British Columbia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182798&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search XDN 1V0K,1FH7,1V0M 445612 104067413 CHEMBL110830 ZINC14658010 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924514 CCCCCCCCCN1[C@H]2[C@H]([C@H](O)[C@@H](O)[C@H](O)[C@H]2O)N(CCCCCCCCC)C1=O InChI=1S/C25H48N2O5/c1-3-5-7-9-11-13-15-17-26-19-20(22(29)24(31)23(30)21(19)28)27(25(26)32)18-16-14-12-10-8-6-4-2/h19-24,28-31H,3-18H2,1-2H3/t19-,20+,21-,22-,23+,24+/m0/s1 VMWMAUABGMKKID-JGQJCFNXSA-N 50379101 CHEMBL2012656 Lysosomal acid glucosylceramidase Homo sapiens 700 5.2 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379101&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 70683209 160858184 CHEMBL2012656 ZINC84603854 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924515 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1NCCCCCCCCC InChI=1S/C24H50N2O4/c1-3-5-7-9-11-13-15-17-25-19-20(22(28)24(30)23(29)21(19)27)26-18-16-14-12-10-8-6-4-2/h19-30H,3-18H2,1-2H3/t19-,20+,21-,22-,23+,24+/m0/s1 OMNVCNBMHSVFPS-JGQJCFNXSA-N 50379102 CHEMBL2012655 Lysosomal acid glucosylceramidase Homo sapiens 26 5.2 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379102&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53475227 160858185 CHEMBL2012655 ZINC84604176 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924516 CCCCCCCCCN[C@@H]1[C@H](N)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H32N2O4/c1-2-3-4-5-6-7-8-9-17-11-10(16)12(18)14(20)15(21)13(11)19/h10-15,17-21H,2-9,16H2,1H3/t10-,11+,12-,13-,14+,15+/m0/s1 OECZZIOVEAKTMH-PMKSJIGOSA-N 50379103 CHEMBL2012654 Lysosomal acid glucosylceramidase Homo sapiens 170 5.2 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379103&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 70693698 160858186 CHEMBL2012654 ZINC84604174 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924517 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 660 5.2 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924518 CCCCCCCCCO[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OCCCCCCCCC InChI=1S/C24H48O6/c1-3-5-7-9-11-13-15-17-29-23-21(27)19(25)20(26)22(28)24(23)30-18-16-14-12-10-8-6-4-2/h19-28H,3-18H2,1-2H3/t19-,20-,21+,22+,23-,24+/m0/s1 FKYONDAKOXLCSE-WQRAYAPSSA-N 50379104 CHEMBL2012659 Lysosomal acid glucosylceramidase Homo sapiens 144000 5.2 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379104&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 70681086 160858187 CHEMBL2012659 ZINC84602344 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924519 N[C@H]1[C@@H](N)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C6H14N2O4/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6,9-12H,7-8H2/t1-,2+,3-,4-,5+,6+/m0/s1 JICPMANWIOEPKV-UZAAGFTCSA-N 50379105 CHEMBL2012657 Lysosomal acid glucosylceramidase Homo sapiens 53400 5.2 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379105&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 12724420 160858188 CHEMBL2012657 ZINC84615300 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924520 CCCCCCCCCN1[C@H]2[C@H]([C@H](O)[C@@H](O)[C@H](O)[C@H]2O)N(CCCCCCCCC)C1=O InChI=1S/C25H48N2O5/c1-3-5-7-9-11-13-15-17-26-19-20(22(29)24(31)23(30)21(19)28)27(25(26)32)18-16-14-12-10-8-6-4-2/h19-24,28-31H,3-18H2,1-2H3/t19-,20+,21-,22-,23+,24+/m0/s1 VMWMAUABGMKKID-JGQJCFNXSA-N 50379101 CHEMBL2012656 Lysosomal acid glucosylceramidase Homo sapiens 1610 5.2 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379101&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 70683209 160858184 CHEMBL2012656 ZINC84603854 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924521 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1NCCCCCCCCC InChI=1S/C24H50N2O4/c1-3-5-7-9-11-13-15-17-25-19-20(22(28)24(30)23(29)21(19)27)26-18-16-14-12-10-8-6-4-2/h19-30H,3-18H2,1-2H3/t19-,20+,21-,22-,23+,24+/m0/s1 OMNVCNBMHSVFPS-JGQJCFNXSA-N 50379102 CHEMBL2012655 Lysosomal acid glucosylceramidase Homo sapiens 90 5.2 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379102&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53475227 160858185 CHEMBL2012655 ZINC84604176 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924522 CCCCCCCCCN[C@@H]1[C@H](N)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H32N2O4/c1-2-3-4-5-6-7-8-9-17-11-10(16)12(18)14(20)15(21)13(11)19/h10-15,17-21H,2-9,16H2,1H3/t10-,11+,12-,13-,14+,15+/m0/s1 OECZZIOVEAKTMH-PMKSJIGOSA-N 50379103 CHEMBL2012654 Lysosomal acid glucosylceramidase Homo sapiens 640 5.2 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379103&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 70693698 160858186 CHEMBL2012654 ZINC84604174 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924523 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 300 7 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924524 N[C@H]1[C@@H](N)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C6H14N2O4/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6,9-12H,7-8H2/t1-,2+,3-,4-,5+,6+/m0/s1 JICPMANWIOEPKV-UZAAGFTCSA-N 50379105 CHEMBL2012657 Lysosomal acid glucosylceramidase Homo sapiens 44400 7 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379105&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 12724420 160858188 CHEMBL2012657 ZINC84615300 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924525 CCCCCCCCCN1[C@H]2[C@H]([C@H](O)[C@@H](O)[C@H](O)[C@H]2O)N(CCCCCCCCC)C1=O InChI=1S/C25H48N2O5/c1-3-5-7-9-11-13-15-17-26-19-20(22(29)24(31)23(30)21(19)28)27(25(26)32)18-16-14-12-10-8-6-4-2/h19-24,28-31H,3-18H2,1-2H3/t19-,20+,21-,22-,23+,24+/m0/s1 VMWMAUABGMKKID-JGQJCFNXSA-N 50379101 CHEMBL2012656 Lysosomal acid glucosylceramidase Homo sapiens 1210 7 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379101&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 70683209 160858184 CHEMBL2012656 ZINC84603854 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924526 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1NCCCCCCCCC InChI=1S/C24H50N2O4/c1-3-5-7-9-11-13-15-17-25-19-20(22(28)24(30)23(29)21(19)27)26-18-16-14-12-10-8-6-4-2/h19-30H,3-18H2,1-2H3/t19-,20+,21-,22-,23+,24+/m0/s1 OMNVCNBMHSVFPS-JGQJCFNXSA-N 50379102 CHEMBL2012655 Lysosomal acid glucosylceramidase Homo sapiens 56 7 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379102&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53475227 160858185 CHEMBL2012655 ZINC84604176 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924527 CCCCCCCCCN[C@@H]1[C@H](N)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H32N2O4/c1-2-3-4-5-6-7-8-9-17-11-10(16)12(18)14(20)15(21)13(11)19/h10-15,17-21H,2-9,16H2,1H3/t10-,11+,12-,13-,14+,15+/m0/s1 OECZZIOVEAKTMH-PMKSJIGOSA-N 50379103 CHEMBL2012654 Lysosomal acid glucosylceramidase Homo sapiens 81 7 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379103&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 70693698 160858186 CHEMBL2012654 ZINC84604174 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924528 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 300 5.2 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50924529 CCCCCCCCCO[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OCCCCCCCCC InChI=1S/C24H48O6/c1-3-5-7-9-11-13-15-17-29-23-21(27)19(25)20(26)22(28)24(23)30-18-16-14-12-10-8-6-4-2/h19-28H,3-18H2,1-2H3/t19-,20-,21+,22+,23-,24+/m0/s1 FKYONDAKOXLCSE-WQRAYAPSSA-N 50379104 CHEMBL2012659 Lysosomal acid glucosylceramidase Homo sapiens 49300 7 ChEMBL 10.1021/ml200098j 10.7270/Q2R78G6C 24900357 Trapero, A; Llebaria, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50379104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50379104&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 70681086 160858187 CHEMBL2012659 ZINC84602344 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962406 CCCCCCCCCO[C@H]1[C@@H](N)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-21-15-10(16)11(17)12(18)13(19)14(15)20/h10-15,17-20H,2-9,16H2,1H3/t10-,11-,12+,13-,14+,15-/m0/s1 WKAQFLWIVFXKDW-UJOWSUJOSA-N 50394824 CHEMBL2164232 Lysosomal acid glucosylceramidase Homo sapiens 130 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394824&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522159 163343848 CHEMBL2164232 ZINC95552063 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962407 CCCCCCCCCO[C@H]1[C@@H](N)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-21-15-10(16)11(17)12(18)13(19)14(15)20/h10-15,17-20H,2-9,16H2,1H3/t10-,11-,12+,13-,14+,15-/m0/s1 WKAQFLWIVFXKDW-UJOWSUJOSA-N 50394824 CHEMBL2164232 Lysosomal acid glucosylceramidase Homo sapiens 130 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394824&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522159 163343848 CHEMBL2164232 ZINC95552063 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962408 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OC InChI=1S/C16H33NO5/c1-3-4-5-6-7-8-9-10-17-11-12(18)13(19)14(20)15(21)16(11)22-2/h11-21H,3-10H2,1-2H3/t11-,12-,13+,14-,15+,16-/m0/s1 XIVQQGYSZPSBSE-KLOLGFOXSA-N 50394825 CHEMBL2164230 Lysosomal acid glucosylceramidase Homo sapiens 130 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394825&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522155 163343849 CHEMBL2164230 ZINC95556445 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962409 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OC InChI=1S/C16H33NO5/c1-3-4-5-6-7-8-9-10-17-11-12(18)13(19)14(20)15(21)16(11)22-2/h11-21H,3-10H2,1-2H3/t11-,12-,13+,14-,15+,16-/m0/s1 XIVQQGYSZPSBSE-KLOLGFOXSA-N 50394825 CHEMBL2164230 Lysosomal acid glucosylceramidase Homo sapiens 130 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394825&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522155 163343849 CHEMBL2164230 ZINC95556445 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962410 CCCCCCCCCO[C@H]1[C@@H](N)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-21-15-10(16)11(17)12(18)13(19)14(15)20/h10-15,17-20H,2-9,16H2,1H3/t10-,11-,12+,13-,14+,15-/m0/s1 WKAQFLWIVFXKDW-UJOWSUJOSA-N 50394824 CHEMBL2164232 Lysosomal acid glucosylceramidase Homo sapiens 120 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394824&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522159 163343848 CHEMBL2164232 ZINC95552063 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962411 CCCCCCCCCO[C@H]1[C@@H](N)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-21-15-10(16)11(17)12(18)13(19)14(15)20/h10-15,17-20H,2-9,16H2,1H3/t10-,11-,12+,13-,14+,15-/m0/s1 WKAQFLWIVFXKDW-UJOWSUJOSA-N 50394824 CHEMBL2164232 Lysosomal acid glucosylceramidase Homo sapiens 120 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394824&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522159 163343848 CHEMBL2164232 ZINC95552063 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962412 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11-,12-,13+,14-,15-/m0/s1 VZSLDWKNYXFVNT-SOAFEQHCSA-N 50394826 CHEMBL2164227 Lysosomal acid glucosylceramidase Homo sapiens 80 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394826&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522149 163343850 CHEMBL2164227 ZINC95552175 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962413 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11-,12-,13+,14-,15-/m0/s1 VZSLDWKNYXFVNT-SOAFEQHCSA-N 50394826 CHEMBL2164227 Lysosomal acid glucosylceramidase Homo sapiens 80 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394826&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522149 163343850 CHEMBL2164227 ZINC95552175 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962414 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OC InChI=1S/C16H33NO5/c1-3-4-5-6-7-8-9-10-17-11-12(18)13(19)14(20)15(21)16(11)22-2/h11-21H,3-10H2,1-2H3/t11-,12-,13+,14-,15+,16-/m0/s1 XIVQQGYSZPSBSE-KLOLGFOXSA-N 50394825 CHEMBL2164230 Lysosomal acid glucosylceramidase Homo sapiens 53 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394825&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522155 163343849 CHEMBL2164230 ZINC95556445 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962415 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OC InChI=1S/C16H33NO5/c1-3-4-5-6-7-8-9-10-17-11-12(18)13(19)14(20)15(21)16(11)22-2/h11-21H,3-10H2,1-2H3/t11-,12-,13+,14-,15+,16-/m0/s1 XIVQQGYSZPSBSE-KLOLGFOXSA-N 50394825 CHEMBL2164230 Lysosomal acid glucosylceramidase Homo sapiens 53 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394825&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522155 163343849 CHEMBL2164230 ZINC95556445 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962416 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11-,12-,13+,14-,15-/m0/s1 VZSLDWKNYXFVNT-SOAFEQHCSA-N 50394826 CHEMBL2164227 Lysosomal acid glucosylceramidase Homo sapiens 32 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394826&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522149 163343850 CHEMBL2164227 ZINC95552175 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962417 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11-,12-,13+,14-,15-/m0/s1 VZSLDWKNYXFVNT-SOAFEQHCSA-N 50394826 CHEMBL2164227 Lysosomal acid glucosylceramidase Homo sapiens 32 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394826&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522149 163343850 CHEMBL2164227 ZINC95552175 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962418 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11-,12-,13+,14-,15-/m0/s1 VZSLDWKNYXFVNT-SOAFEQHCSA-N 50394826 CHEMBL2164227 Lysosomal acid glucosylceramidase Homo sapiens 25 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394826&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522149 163343850 CHEMBL2164227 ZINC95552175 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962419 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11-,12-,13+,14-,15-/m0/s1 VZSLDWKNYXFVNT-SOAFEQHCSA-N 50394826 CHEMBL2164227 Lysosomal acid glucosylceramidase Homo sapiens 25 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394826&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522149 163343850 CHEMBL2164227 ZINC95552175 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962420 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OC InChI=1S/C16H33NO5/c1-3-4-5-6-7-8-9-10-17-11-12(18)13(19)14(20)15(21)16(11)22-2/h11-21H,3-10H2,1-2H3/t11-,12-,13+,14-,15+,16-/m0/s1 XIVQQGYSZPSBSE-KLOLGFOXSA-N 50394825 CHEMBL2164230 Lysosomal acid glucosylceramidase Homo sapiens 19 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394825&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522155 163343849 CHEMBL2164230 ZINC95556445 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962421 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OC InChI=1S/C16H33NO5/c1-3-4-5-6-7-8-9-10-17-11-12(18)13(19)14(20)15(21)16(11)22-2/h11-21H,3-10H2,1-2H3/t11-,12-,13+,14-,15+,16-/m0/s1 XIVQQGYSZPSBSE-KLOLGFOXSA-N 50394825 CHEMBL2164230 Lysosomal acid glucosylceramidase Homo sapiens 19 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394825&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522155 163343849 CHEMBL2164230 ZINC95556445 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962422 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24-/m0/s1 FCGZSNKVXACTQQ-FHWMYVSESA-N 50394827 CHEMBL2164231 Lysosomal acid glucosylceramidase Homo sapiens 5 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394827&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522157 163343851 CHEMBL2164231 ZINC95552456 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962423 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24-/m0/s1 FCGZSNKVXACTQQ-FHWMYVSESA-N 50394827 CHEMBL2164231 Lysosomal acid glucosylceramidase Homo sapiens 5 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394827&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522157 163343851 CHEMBL2164231 ZINC95552456 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962424 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24-/m0/s1 FCGZSNKVXACTQQ-FHWMYVSESA-N 50394827 CHEMBL2164231 Lysosomal acid glucosylceramidase Homo sapiens 4 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394827&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522157 163343851 CHEMBL2164231 ZINC95552456 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962425 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24-/m0/s1 FCGZSNKVXACTQQ-FHWMYVSESA-N 50394827 CHEMBL2164231 Lysosomal acid glucosylceramidase Homo sapiens 4 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394827&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522157 163343851 CHEMBL2164231 ZINC95552456 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962426 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24-/m0/s1 FCGZSNKVXACTQQ-FHWMYVSESA-N 50394827 CHEMBL2164231 Lysosomal acid glucosylceramidase Homo sapiens 1 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394827&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522157 163343851 CHEMBL2164231 ZINC95552456 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962427 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24-/m0/s1 FCGZSNKVXACTQQ-FHWMYVSESA-N 50394827 CHEMBL2164231 Lysosomal acid glucosylceramidase Homo sapiens 1 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394827&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522157 163343851 CHEMBL2164231 ZINC95552456 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962428 CCCCCCCCCN[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11-,12+,13+,14-,15- VZSLDWKNYXFVNT-JYBHGSPCSA-N 50394828 CHEMBL2163840 Lysosomal acid glucosylceramidase Homo sapiens 3900 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394828&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522037 163343852 CHEMBL2163840 ZINC95552573 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962429 CCCCCCCCCN[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11-,12+,13+,14-,15- VZSLDWKNYXFVNT-JYBHGSPCSA-N 50394828 CHEMBL2163840 Lysosomal acid glucosylceramidase Homo sapiens 3900 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394828&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522037 163343852 CHEMBL2163840 ZINC95552573 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962430 CCCCCCCCCN[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11-,12+,13+,14-,15- VZSLDWKNYXFVNT-JYBHGSPCSA-N 50394828 CHEMBL2163840 Lysosomal acid glucosylceramidase Homo sapiens 1900 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394828&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522037 163343852 CHEMBL2163840 ZINC95552573 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962431 CCCCCCCCCN[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11-,12+,13+,14-,15- VZSLDWKNYXFVNT-JYBHGSPCSA-N 50394828 CHEMBL2163840 Lysosomal acid glucosylceramidase Homo sapiens 1900 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394828&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522037 163343852 CHEMBL2163840 ZINC95552573 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962432 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 660 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962433 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 660 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962434 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 300 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962435 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 300 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962436 CCCCCCCCCN[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11+,12-,13-,14+,15+ VZSLDWKNYXFVNT-ADUPDYIFSA-N 50394829 CHEMBL2163841 Lysosomal acid glucosylceramidase Homo sapiens 52600 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394829&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522037 163343853 CHEMBL2163841 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962437 CCCCCCCCCN[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11+,12-,13-,14+,15+ VZSLDWKNYXFVNT-ADUPDYIFSA-N 50394829 CHEMBL2163841 Lysosomal acid glucosylceramidase Homo sapiens 52600 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394829&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522037 163343853 CHEMBL2163841 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962438 CCCCCCCCCN[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11+,12-,13-,14+,15+ VZSLDWKNYXFVNT-ADUPDYIFSA-N 50394829 CHEMBL2163841 Lysosomal acid glucosylceramidase Homo sapiens 24900 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394829&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522037 163343853 CHEMBL2163841 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962439 CCCCCCCCCN[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11+,12-,13-,14+,15+ VZSLDWKNYXFVNT-ADUPDYIFSA-N 50394829 CHEMBL2163841 Lysosomal acid glucosylceramidase Homo sapiens 24900 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394829&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522037 163343853 CHEMBL2163841 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962440 CCCCCCCCCN[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11+,12-,13-,14+,15+ VZSLDWKNYXFVNT-ADUPDYIFSA-N 50394829 CHEMBL2163841 Lysosomal acid glucosylceramidase Homo sapiens 17900 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394829&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522037 163343853 CHEMBL2163841 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962441 CCCCCCCCCN[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11+,12-,13-,14+,15+ VZSLDWKNYXFVNT-ADUPDYIFSA-N 50394829 CHEMBL2163841 Lysosomal acid glucosylceramidase Homo sapiens 17900 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394829&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522037 163343853 CHEMBL2163841 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962442 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC InChI=1S/C16H33NO5/c1-3-4-5-6-7-8-9-10-17-11-12(18)13(19)14(20)15(21)16(11)22-2/h11-21H,3-10H2,1-2H3/t11-,12-,13+,14-,15+,16+/m0/s1 XIVQQGYSZPSBSE-RWHKXBQASA-N 50394830 CHEMBL2164228 Lysosomal acid glucosylceramidase Homo sapiens 4400 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394830&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522151 163343854 CHEMBL2164228 ZINC95556011 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962443 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC InChI=1S/C16H33NO5/c1-3-4-5-6-7-8-9-10-17-11-12(18)13(19)14(20)15(21)16(11)22-2/h11-21H,3-10H2,1-2H3/t11-,12-,13+,14-,15+,16+/m0/s1 XIVQQGYSZPSBSE-RWHKXBQASA-N 50394830 CHEMBL2164228 Lysosomal acid glucosylceramidase Homo sapiens 4400 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394830&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522151 163343854 CHEMBL2164228 ZINC95556011 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962444 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24-/m0/s1 FCGZSNKVXACTQQ-FHWMYVSESA-N 50394827 CHEMBL2164231 Lysosomal acid glucosylceramidase Homo sapiens 4.3 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394827&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522157 163343851 CHEMBL2164231 ZINC95552456 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962445 CCCCCCCCCN(CCCCCCCCC)[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25(18-16-14-12-10-8-6-4-2)19-20(26)22(28)24(30)23(29)21(19)27/h19-24,26-30H,3-18H2,1-2H3/t19-,20-,21-,22+,23-,24-/m0/s1 SLEYSFCYPAGQCC-WMGXJHCHSA-N 50394831 CHEMBL2164233 Lysosomal acid glucosylceramidase Homo sapiens 1720 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394831&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522161 163343855 CHEMBL2164233 ZINC95556390 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962446 CCCCCCCCCN(CCCCCCCCC)[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25(18-16-14-12-10-8-6-4-2)19-20(26)22(28)24(30)23(29)21(19)27/h19-24,26-30H,3-18H2,1-2H3/t19-,20-,21-,22+,23-,24-/m0/s1 SLEYSFCYPAGQCC-WMGXJHCHSA-N 50394831 CHEMBL2164233 Lysosomal acid glucosylceramidase Homo sapiens 1720 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394831&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522161 163343855 CHEMBL2164233 ZINC95556390 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962447 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC InChI=1S/C16H33NO5/c1-3-4-5-6-7-8-9-10-17-11-12(18)13(19)14(20)15(21)16(11)22-2/h11-21H,3-10H2,1-2H3/t11-,12-,13+,14-,15+,16+/m0/s1 XIVQQGYSZPSBSE-RWHKXBQASA-N 50394830 CHEMBL2164228 Lysosomal acid glucosylceramidase Homo sapiens 1580 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394830&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522151 163343854 CHEMBL2164228 ZINC95556011 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962448 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC InChI=1S/C16H33NO5/c1-3-4-5-6-7-8-9-10-17-11-12(18)13(19)14(20)15(21)16(11)22-2/h11-21H,3-10H2,1-2H3/t11-,12-,13+,14-,15+,16+/m0/s1 XIVQQGYSZPSBSE-RWHKXBQASA-N 50394830 CHEMBL2164228 Lysosomal acid glucosylceramidase Homo sapiens 1580 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394830&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522151 163343854 CHEMBL2164228 ZINC95556011 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962449 CCCCCCCCCN(CCCCCCCCC)[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25(18-16-14-12-10-8-6-4-2)19-20(26)22(28)24(30)23(29)21(19)27/h19-24,26-30H,3-18H2,1-2H3/t19-,20-,21-,22+,23-,24-/m0/s1 SLEYSFCYPAGQCC-WMGXJHCHSA-N 50394831 CHEMBL2164233 Lysosomal acid glucosylceramidase Homo sapiens 820 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394831&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522161 163343855 CHEMBL2164233 ZINC95556390 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962450 CCCCCCCCCN(CCCCCCCCC)[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25(18-16-14-12-10-8-6-4-2)19-20(26)22(28)24(30)23(29)21(19)27/h19-24,26-30H,3-18H2,1-2H3/t19-,20-,21-,22+,23-,24-/m0/s1 SLEYSFCYPAGQCC-WMGXJHCHSA-N 50394831 CHEMBL2164233 Lysosomal acid glucosylceramidase Homo sapiens 820 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394831&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522161 163343855 CHEMBL2164233 ZINC95556390 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962451 CCCCCCCCCN[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11-,12+,13+,14-,15- VZSLDWKNYXFVNT-JYBHGSPCSA-N 50394828 CHEMBL2163840 Lysosomal acid glucosylceramidase Homo sapiens 780 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394828&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522037 163343852 CHEMBL2163840 ZINC95552573 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962452 CCCCCCCCCN[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-16-10-11(17)13(19)15(21)14(20)12(10)18/h10-21H,2-9H2,1H3/t10-,11-,12+,13+,14-,15- VZSLDWKNYXFVNT-JYBHGSPCSA-N 50394828 CHEMBL2163840 Lysosomal acid glucosylceramidase Homo sapiens 780 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394828&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522037 163343852 CHEMBL2163840 ZINC95552573 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962453 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC InChI=1S/C16H33NO5/c1-3-4-5-6-7-8-9-10-17-11-12(18)13(19)14(20)15(21)16(11)22-2/h11-21H,3-10H2,1-2H3/t11-,12-,13+,14-,15+,16+/m0/s1 XIVQQGYSZPSBSE-RWHKXBQASA-N 50394830 CHEMBL2164228 Lysosomal acid glucosylceramidase Homo sapiens 670 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394830&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522151 163343854 CHEMBL2164228 ZINC95556011 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962454 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24+/m0/s1 FCGZSNKVXACTQQ-FSDTYVLISA-N 50394823 CHEMBL2164229 Lysosomal acid glucosylceramidase Homo sapiens 670 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394823&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522153 163343847 CHEMBL2164229 ZINC95554985 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962405 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24+/m0/s1 FCGZSNKVXACTQQ-FSDTYVLISA-N 50394823 CHEMBL2164229 Lysosomal acid glucosylceramidase Homo sapiens 170 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394823&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522153 163343847 CHEMBL2164229 ZINC95554985 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962455 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC InChI=1S/C16H33NO5/c1-3-4-5-6-7-8-9-10-17-11-12(18)13(19)14(20)15(21)16(11)22-2/h11-21H,3-10H2,1-2H3/t11-,12-,13+,14-,15+,16+/m0/s1 XIVQQGYSZPSBSE-RWHKXBQASA-N 50394830 CHEMBL2164228 Lysosomal acid glucosylceramidase Homo sapiens 670 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394830&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522151 163343854 CHEMBL2164228 ZINC95556011 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962456 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24+/m0/s1 FCGZSNKVXACTQQ-FSDTYVLISA-N 50394823 CHEMBL2164229 Lysosomal acid glucosylceramidase Homo sapiens 670 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394823&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522153 163343847 CHEMBL2164229 ZINC95554985 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962457 CCCCCCCCCN(CCCCCCCCC)[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25(18-16-14-12-10-8-6-4-2)19-20(26)22(28)24(30)23(29)21(19)27/h19-24,26-30H,3-18H2,1-2H3/t19-,20-,21-,22+,23-,24-/m0/s1 SLEYSFCYPAGQCC-WMGXJHCHSA-N 50394831 CHEMBL2164233 Lysosomal acid glucosylceramidase Homo sapiens 530 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394831&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522161 163343855 CHEMBL2164233 ZINC95556390 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962458 CCCCCCCCCN(CCCCCCCCC)[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25(18-16-14-12-10-8-6-4-2)19-20(26)22(28)24(30)23(29)21(19)27/h19-24,26-30H,3-18H2,1-2H3/t19-,20-,21-,22+,23-,24-/m0/s1 SLEYSFCYPAGQCC-WMGXJHCHSA-N 50394831 CHEMBL2164233 Lysosomal acid glucosylceramidase Homo sapiens 530 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394831&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522161 163343855 CHEMBL2164233 ZINC95556390 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962459 CCCCCCCCCO[C@H]1[C@@H](N)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-21-15-10(16)11(17)12(18)13(19)14(15)20/h10-15,17-20H,2-9,16H2,1H3/t10-,11-,12+,13-,14+,15-/m0/s1 WKAQFLWIVFXKDW-UJOWSUJOSA-N 50394824 CHEMBL2164232 Lysosomal acid glucosylceramidase Homo sapiens 450 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394824&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522159 163343848 CHEMBL2164232 ZINC95552063 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962460 CCCCCCCCCO[C@H]1[C@@H](N)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C15H31NO5/c1-2-3-4-5-6-7-8-9-21-15-10(16)11(17)12(18)13(19)14(15)20/h10-15,17-20H,2-9,16H2,1H3/t10-,11-,12+,13-,14+,15-/m0/s1 WKAQFLWIVFXKDW-UJOWSUJOSA-N 50394824 CHEMBL2164232 Lysosomal acid glucosylceramidase Homo sapiens 450 5.2 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394824&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522159 163343848 CHEMBL2164232 ZINC95552063 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962461 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 300 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962462 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 300 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962463 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24+/m0/s1 FCGZSNKVXACTQQ-FSDTYVLISA-N 50394823 CHEMBL2164229 Lysosomal acid glucosylceramidase Homo sapiens 280 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394823&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522153 163343847 CHEMBL2164229 ZINC95554985 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962464 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24+/m0/s1 FCGZSNKVXACTQQ-FSDTYVLISA-N 50394823 CHEMBL2164229 Lysosomal acid glucosylceramidase Homo sapiens 280 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394823&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522153 163343847 CHEMBL2164229 ZINC95554985 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50962465 CCCCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OCCCCCCCCC InChI=1S/C24H49NO5/c1-3-5-7-9-11-13-15-17-25-19-20(26)21(27)22(28)23(29)24(19)30-18-16-14-12-10-8-6-4-2/h19-29H,3-18H2,1-2H3/t19-,20-,21+,22-,23+,24+/m0/s1 FCGZSNKVXACTQQ-FSDTYVLISA-N 50394823 CHEMBL2164229 Lysosomal acid glucosylceramidase Homo sapiens 170 7 ChEMBL 10.1021/jm300342q 10.7270/Q2GQ6ZV8 22512696 Trapero, A; Gonzalez-Bulnes, P; Butters, TD; Llebaria, A Institut de Qu£mica Avan£ada de Catalunya (IQAC-CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394823&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 57522153 163343847 CHEMBL2164229 ZINC95554985 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50966075 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 30 ChEMBL 10.1021/jm300063b 10.7270/Q2H70GZ1 22646221 Patnaik, S; Zheng, W; Choi, JH; Motabar, O; Southall, N; Westbroek, W; Lea, WA; Velayati, A; Goldin, E; Sidransky, E; Leister, W; Marugan, JJ National Center for Advancing Translation Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50966076 Clc1ccc(CN(CCCNC(=S)NCCCc2cnc[nH]2)c2ccc(Br)cn2)cc1Cl InChI=1S/C22H25BrCl2N6S/c23-17-5-7-21(29-12-17)31(14-16-4-6-19(24)20(25)11-16)10-2-9-28-22(32)27-8-1-3-18-13-26-15-30-18/h4-7,11-13,15H,1-3,8-10,14H2,(H,26,30)(H2,27,28,32) UREJDUPKGMFJRU-UHFFFAOYSA-N 50068039 1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[3-(1H-imidazol-4-yl)-propyl]-thiourea::CHEMBL103769 Lysosomal acid glucosylceramidase Homo sapiens 360 ChEMBL 10.1021/jm300063b 10.7270/Q2H70GZ1 22646221 Patnaik, S; Zheng, W; Choi, JH; Motabar, O; Southall, N; Westbroek, W; Lea, WA; Velayati, A; Goldin, E; Sidransky, E; Leister, W; Marugan, JJ National Center for Advancing Translation Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50068039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50068039&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9893924 103962405 CHEMBL103769 ZINC26815863 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50966077 O=S(=O)(N1CCN(CC1)c1nc(nc2ccccc12)-c1cccs1)c1ccc2ccccc2c1 InChI=1S/C26H22N4O2S2/c31-34(32,21-12-11-19-6-1-2-7-20(19)18-21)30-15-13-29(14-16-30)26-22-8-3-4-9-23(22)27-25(28-26)24-10-5-17-33-24/h1-12,17-18H,13-16H2 WQARUVRGOHJYJX-UHFFFAOYSA-N 50396168 CHEMBL1361379 Lysosomal acid glucosylceramidase Homo sapiens 280 ChEMBL 10.1021/jm300063b 10.7270/Q2H70GZ1 22646221 Patnaik, S; Zheng, W; Choi, JH; Motabar, O; Southall, N; Westbroek, W; Lea, WA; Velayati, A; Goldin, E; Sidransky, E; Leister, W; Marugan, JJ National Center for Advancing Translation Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396168&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 40225210 163345192 CHEMBL1361379 ZINC33010830 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50966078 CCc1nnc(NC(=O)c2ccc(NS(=O)(=O)c3ccccc3)cc2)s1 InChI=1S/C17H16N4O3S2/c1-2-15-19-20-17(25-15)18-16(22)12-8-10-13(11-9-12)21-26(23,24)14-6-4-3-5-7-14/h3-11,21H,2H2,1H3,(H,18,20,22) YMGXUJCEBOCIIT-UHFFFAOYSA-N 18438 4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamide::NCGC00060210::Sulfonamide analogue, 2 Lysosomal acid glucosylceramidase Homo sapiens 3200 ChEMBL 10.1021/jm300063b 10.7270/Q2H70GZ1 22646221 Patnaik, S; Zheng, W; Choi, JH; Motabar, O; Southall, N; Westbroek, W; Lea, WA; Velayati, A; Goldin, E; Sidransky, E; Leister, W; Marugan, JJ National Center for Advancing Translation Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18438&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2210290 46518512 ZINC06267373 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50966079 Cc1cc(nc2ccc(NC(=O)C3CCCCC3)cc12)N1CCOCC1 InChI=1S/C21H27N3O2/c1-15-13-20(24-9-11-26-12-10-24)23-19-8-7-17(14-18(15)19)22-21(25)16-5-3-2-4-6-16/h7-8,13-14,16H,2-6,9-12H2,1H3,(H,22,25) BXVNPOBNVRBOOV-UHFFFAOYSA-N 18428 Aminoquinoline compound, 1::N-[4-methyl-2-(morpholin-4-yl)quinolin-6-yl]cyclohexanecarboxamide::NCGC00092410 Lysosomal acid glucosylceramidase Homo sapiens 2200 ChEMBL 10.1021/jm300063b 10.7270/Q2H70GZ1 22646221 Patnaik, S; Zheng, W; Choi, JH; Motabar, O; Southall, N; Westbroek, W; Lea, WA; Velayati, A; Goldin, E; Sidransky, E; Leister, W; Marugan, JJ National Center for Advancing Translation Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18428&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 5067281 46518503 ZINC03649803 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50966080 COc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCC1 InChI=1S/C16H21ClN6O2/c1-25-13-5-4-11(17)10-12(13)19-15-20-14(18-6-9-24)21-16(22-15)23-7-2-3-8-23/h4-5,10,24H,2-3,6-9H2,1H3,(H2,18,19,20,21,22) AQYDNGDNBIIYOX-UHFFFAOYSA-N 18447 2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::NCGC00029010::Triazine compound, 3::triazine scaffold, 1 Lysosomal acid glucosylceramidase Homo sapiens 7900 ChEMBL 10.1021/jm300063b 10.7270/Q2H70GZ1 22646221 Patnaik, S; Zheng, W; Choi, JH; Motabar, O; Southall, N; Westbroek, W; Lea, WA; Velayati, A; Goldin, E; Sidransky, E; Leister, W; Marugan, JJ National Center for Advancing Translation Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18447&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 650378 46518521 ZINC04400045 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50966081 Clc1ccc(CN(CCCNC(=S)NCCCc2cnc[nH]2)c2ccc(Br)cn2)cc1Cl InChI=1S/C22H25BrCl2N6S/c23-17-5-7-21(29-12-17)31(14-16-4-6-19(24)20(25)11-16)10-2-9-28-22(32)27-8-1-3-18-13-26-15-30-18/h4-7,11-13,15H,1-3,8-10,14H2,(H,26,30)(H2,27,28,32) UREJDUPKGMFJRU-UHFFFAOYSA-N 50068039 1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)-amino]-propyl}-3-[3-(1H-imidazol-4-yl)-propyl]-thiourea::CHEMBL103769 Lysosomal acid glucosylceramidase Homo sapiens 710 ChEMBL 10.1021/jm300063b 10.7270/Q2H70GZ1 22646221 Patnaik, S; Zheng, W; Choi, JH; Motabar, O; Southall, N; Westbroek, W; Lea, WA; Velayati, A; Goldin, E; Sidransky, E; Leister, W; Marugan, JJ National Center for Advancing Translation Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50068039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50068039&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9893924 103962405 CHEMBL103769 ZINC26815863 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50966082 O=S(=O)(N1CCN(CC1)c1nc(nc2ccccc12)-c1cccs1)c1ccc2ccccc2c1 InChI=1S/C26H22N4O2S2/c31-34(32,21-12-11-19-6-1-2-7-20(19)18-21)30-15-13-29(14-16-30)26-22-8-3-4-9-23(22)27-25(28-26)24-10-5-17-33-24/h1-12,17-18H,13-16H2 WQARUVRGOHJYJX-UHFFFAOYSA-N 50396168 CHEMBL1361379 Lysosomal acid glucosylceramidase Homo sapiens 8900 ChEMBL 10.1021/jm300063b 10.7270/Q2H70GZ1 22646221 Patnaik, S; Zheng, W; Choi, JH; Motabar, O; Southall, N; Westbroek, W; Lea, WA; Velayati, A; Goldin, E; Sidransky, E; Leister, W; Marugan, JJ National Center for Advancing Translation Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50396168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50396168&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 40225210 163345192 CHEMBL1361379 ZINC33010830 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50966083 CCc1nnc(NC(=O)c2ccc(NS(=O)(=O)c3ccccc3)cc2)s1 InChI=1S/C17H16N4O3S2/c1-2-15-19-20-17(25-15)18-16(22)12-8-10-13(11-9-12)21-26(23,24)14-6-4-3-5-7-14/h3-11,21H,2H2,1H3,(H,18,20,22) YMGXUJCEBOCIIT-UHFFFAOYSA-N 18438 4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamide::NCGC00060210::Sulfonamide analogue, 2 Lysosomal acid glucosylceramidase Homo sapiens 100 ChEMBL 10.1021/jm300063b 10.7270/Q2H70GZ1 22646221 Patnaik, S; Zheng, W; Choi, JH; Motabar, O; Southall, N; Westbroek, W; Lea, WA; Velayati, A; Goldin, E; Sidransky, E; Leister, W; Marugan, JJ National Center for Advancing Translation Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18438&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2210290 46518512 ZINC06267373 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50966084 Cc1cc(nc2ccc(NC(=O)C3CCCCC3)cc12)N1CCOCC1 InChI=1S/C21H27N3O2/c1-15-13-20(24-9-11-26-12-10-24)23-19-8-7-17(14-18(15)19)22-21(25)16-5-3-2-4-6-16/h7-8,13-14,16H,2-6,9-12H2,1H3,(H,22,25) BXVNPOBNVRBOOV-UHFFFAOYSA-N 18428 Aminoquinoline compound, 1::N-[4-methyl-2-(morpholin-4-yl)quinolin-6-yl]cyclohexanecarboxamide::NCGC00092410 Lysosomal acid glucosylceramidase Homo sapiens 30 ChEMBL 10.1021/jm300063b 10.7270/Q2H70GZ1 22646221 Patnaik, S; Zheng, W; Choi, JH; Motabar, O; Southall, N; Westbroek, W; Lea, WA; Velayati, A; Goldin, E; Sidransky, E; Leister, W; Marugan, JJ National Center for Advancing Translation Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18428&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 5067281 46518503 ZINC03649803 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50966085 COc1ccc(Cl)cc1Nc1nc(NCCO)nc(n1)N1CCCC1 InChI=1S/C16H21ClN6O2/c1-25-13-5-4-11(17)10-12(13)19-15-20-14(18-6-9-24)21-16(22-15)23-7-2-3-8-23/h4-5,10,24H,2-3,6-9H2,1H3,(H2,18,19,20,21,22) AQYDNGDNBIIYOX-UHFFFAOYSA-N 18447 2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-yl}amino)ethan-1-ol::NCGC00029010::Triazine compound, 3::triazine scaffold, 1 Lysosomal acid glucosylceramidase Homo sapiens 400 ChEMBL 10.1021/jm300063b 10.7270/Q2H70GZ1 22646221 Patnaik, S; Zheng, W; Choi, JH; Motabar, O; Southall, N; Westbroek, W; Lea, WA; Velayati, A; Goldin, E; Sidransky, E; Leister, W; Marugan, JJ National Center for Advancing Translation Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18447&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 650378 46518521 ZINC04400045 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50964051 Nc1c(Br)cc(Br)cc1CN[C@H]1CC[C@H](O)CC1 InChI=1S/C13H18Br2N2O/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10/h5-6,10-11,17-18H,1-4,7,16H2/t10-,11- JBDGDEWWOUBZPM-XYPYZODXSA-N 50395322 AMBROXOL Lysosomal acid glucosylceramidase Homo sapiens 4100 ChEMBL 10.1021/jm3006178 10.7270/Q2R212GM 22762530 Castilla, J; Risquez, R; Cruz, D; Higaki, K; Nanba, E; Ohno, K; Suzuki, Y; Diaz, Y; Ortiz Mellet, C; Garcia Fernandez, JM; Castillon, S Universitat Rovira i Virgili http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50395322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50395322&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2132 163344346 ZINC00587613 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50964052 OCCCCCCCCCCCCCCCCSC1=N[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O1 InChI=1S/C23H43NO6S/c25-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-31-23-24-22-21(30-23)20(28)19(27)18(17-26)29-22/h18-22,25-28H,1-17H2/t18-,19-,20+,21-,22+/m1/s1 VGMIDHGCFLZJGW-BDHVOXNPSA-N 50395323 CHEMBL2164031 Lysosomal acid glucosylceramidase Homo sapiens 11400 ChEMBL 10.1021/jm3006178 10.7270/Q2R212GM 22762530 Castilla, J; Risquez, R; Cruz, D; Higaki, K; Nanba, E; Ohno, K; Suzuki, Y; Diaz, Y; Ortiz Mellet, C; Garcia Fernandez, JM; Castillon, S Universitat Rovira i Virgili http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50395323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50395323&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 60200911 163344347 CHEMBL2164031 ZINC95553685 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544569 O[C@@H]1CNC2(CC2)[C@H](\C=C/F)[C@H]1O InChI=1S/C9H14FNO2/c10-4-1-6-8(13)7(12)5-11-9(6)2-3-9/h1,4,6-8,11-13H,2-3,5H2/b4-1-/t6-,7-,8-/m1/s1 OMLFGBKTKHVSQF-XZFIUINESA-N 285835 (6R,7R,8S)-8-((Z)-2-fluorovinyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 17::US9796680, Example 17 Lysosomal acid glucosylceramidase Homo sapiens 36.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285835&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197675 378169472 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50974595 CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 UQRORFVVSGFNRO-UTINFBMNSA-N 18355 (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol::CHEMBL1029::MIGLUSTAT::N-Butyl-DNJ::US9181184, 5 Lysosomal acid glucosylceramidase Homo sapiens 399000 ChEMBL 10.1021/jm301304e 10.7270/Q2K35VTX 23106358 Kato, A; Hayashi, E; Miyauchi, S; Adachi, I; Imahori, T; Natori, Y; Yoshimura, Y; Nash, RJ; Shimaoka, H; Nakagome, I; Koseki, J; Hirono, S; Takahata, H University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18355&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NBV 5IEF,2V3D 51634 46518432 50381 CHEMBL1029 DB00419 4841 ZINC03794711 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50974596 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 LXBIFEVIBLOUGU-JGWLITMVSA-N 18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US9181184, 1::dNM Lysosomal acid glucosylceramidase Homo sapiens 195000 ChEMBL 10.1021/jm301304e 10.7270/Q2K35VTX 23106358 Kato, A; Hayashi, E; Miyauchi, S; Adachi, I; Imahori, T; Natori, Y; Yoshimura, Y; Nash, RJ; Shimaoka, H; Nakagome, I; Koseki, J; Hirono, S; Takahata, H University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DNJ 1DIE,1DOG,1I75,1OIM,2J77,2JKE,2PWD,3GBE,3GXT 29435 46518429 44369 CHEMBL307429 4642 C16843 ZINC03794714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50974597 CCCC[C@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C10H21NO4/c1-2-3-4-6-8(13)10(15)9(14)7(5-12)11-6/h6-15H,2-5H2,1H3/t6-,7-,8+,9-,10-/m1/s1 ZSNFEMNRWFDMNU-HOTMZDKISA-N 18361 (2R,3S,4R,5R,6R)-2-butyl-6-(hydroxymethyl)piperidine-3,4,5-triol::alpha-1-C-Butyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 70000 ChEMBL 10.1021/jm301304e 10.7270/Q2K35VTX 23106358 Kato, A; Hayashi, E; Miyauchi, S; Adachi, I; Imahori, T; Natori, Y; Yoshimura, Y; Nash, RJ; Shimaoka, H; Nakagome, I; Koseki, J; Hirono, S; Takahata, H University of Toyama http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18361&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11009466 46518438 ZINC14967770 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010698 CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 UQRORFVVSGFNRO-UTINFBMNSA-N 18355 (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol::CHEMBL1029::MIGLUSTAT::N-Butyl-DNJ::US9181184, 5 Lysosomal acid glucosylceramidase Homo sapiens 259000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18355&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NBV 5IEF,2V3D 51634 46518432 50381 CHEMBL1029 DB00419 4841 ZINC03794711 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010699 CC(=O)N[C@H]1CN(CCCCCCO)C(=O)[C@H](O)[C@@H]1O InChI=1S/C13H24N2O5/c1-9(17)14-10-8-15(6-4-2-3-5-7-16)13(20)12(19)11(10)18/h10-12,16,18-19H,2-8H2,1H3,(H,14,17)/t10-,11+,12+/m0/s1 IDBGAAOAJFHYIS-QJPTWQEYSA-N 50413895 CHEMBL526183 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413895&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566037 163362919 CHEMBL526183 ZINC40977595 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010700 OCCCCCCN1C[C@@H](O)[C@@H](O)[C@@H](O)C1=O InChI=1S/C11H21NO5/c13-6-4-2-1-3-5-12-7-8(14)9(15)10(16)11(12)17/h8-10,13-16H,1-7H2/t8-,9-,10-/m1/s1 CYBLNFUNMQDVCN-OPRDCNLKSA-N 50413896 CHEMBL491745 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413896&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566036 163362920 CHEMBL491745 ZINC40949641 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010701 O[C@@H]1CN(Cc2ccccc2)C(=O)[C@@H](O)[C@@H]1O InChI=1S/C12H15NO4/c14-9-7-13(12(17)11(16)10(9)15)6-8-4-2-1-3-5-8/h1-5,9-11,14-16H,6-7H2/t9-,10-,11+/m1/s1 MECCYBVTZNHJMA-MXWKQRLJSA-N 50413897 CHEMBL490661 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413897&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566014 163362921 CHEMBL490661 ZINC45506588 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010702 OCCCCCCN1C[C@@H](O)[C@@H](O)[C@H](O)C1=O InChI=1S/C11H21NO5/c13-6-4-2-1-3-5-12-7-8(14)9(15)10(16)11(12)17/h8-10,13-16H,1-7H2/t8-,9-,10+/m1/s1 CYBLNFUNMQDVCN-BBBLOLIVSA-N 50413898 CHEMBL448517 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413898&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44138545 163362922 CHEMBL448517 ZINC40834031 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010703 OCCN1C[C@@H](O)[C@@H](O)[C@H](O)C1=O InChI=1S/C7H13NO5/c9-2-1-8-3-4(10)5(11)6(12)7(8)13/h4-6,9-12H,1-3H2/t4-,5-,6+/m1/s1 MBGGPRYWVLDPIW-PBXRRBTRSA-N 50413899 CHEMBL499827 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413899&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566015 163362923 CHEMBL499827 ZINC40827678 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010704 CCCCCCCCN1C[C@@H](O)C(O)[C@H](O)C1 InChI=1S/C13H27NO3/c1-2-3-4-5-6-7-8-14-9-11(15)13(17)12(16)10-14/h11-13,15-17H,2-10H2,1H3/t11-,12-/m1/s1 PCHZTBUOIUSSAT-VXGBXAGGSA-N 50413900 CHEMBL490751 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413900&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566056 163362924 CHEMBL490751 ZINC49878641 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010705 OCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)C1=O InChI=1S/C11H21NO5/c13-6-4-2-1-3-5-12-7-8(14)9(15)10(16)11(12)17/h8-10,13-16H,1-7H2/t8-,9+,10-/m0/s1 CYBLNFUNMQDVCN-AEJSXWLSSA-N 50413901 CHEMBL491915 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413901&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44140485 163362925 CHEMBL491915 ZINC40949901 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010706 CCCCCCCCCCN1C[C@@H](O)[C@@H](O)C1=O InChI=1S/C14H27NO3/c1-2-3-4-5-6-7-8-9-10-15-11-12(16)13(17)14(15)18/h12-13,16-17H,2-11H2,1H3/t12-,13-/m1/s1 AKGADVWJSWIGAE-CHWSQXEVSA-N 50413902 CHEMBL491744 Lysosomal acid glucosylceramidase Homo sapiens 285000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413902&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566035 163362926 CHEMBL491744 ZINC49878504 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010707 O[C@@H]1CNC(=O)[C@@H](O)[C@@H]1O InChI=1S/C5H9NO4/c7-2-1-6-5(10)4(9)3(2)8/h2-4,7-9H,1H2,(H,6,10)/t2-,3-,4+/m1/s1 RRRFLTNCMKVVNJ-JJYYJPOSSA-N 50413903 CHEMBL491731 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413903&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11062529 163362927 52910 CHEMBL491731 ZINC34621688 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010708 CCCCCCCCN1C[C@@H](O)[C@@H](O)[C@H](O)C1=O InChI=1S/C13H25NO4/c1-2-3-4-5-6-7-8-14-9-10(15)11(16)12(17)13(14)18/h10-12,15-17H,2-9H2,1H3/t10-,11-,12+/m1/s1 ARSDMUNVPUHCFJ-UTUOFQBUSA-N 50413904 CHEMBL491718 Lysosomal acid glucosylceramidase Homo sapiens 175000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413904&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566012 163362928 CHEMBL491718 ZINC49878161 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010709 CCCCN1C[C@@H](O)[C@@H](O)[C@H](O)C1=O InChI=1S/C9H17NO4/c1-2-3-4-10-5-6(11)7(12)8(13)9(10)14/h6-8,11-13H,2-5H2,1H3/t6-,7-,8+/m1/s1 ARXCYPVZALWGFA-PRJMDXOYSA-N 50413905 CHEMBL490714 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413905&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566013 163362929 CHEMBL490714 ZINC45506193 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010710 CCCCCCCCCCN1C[C@H](NC(C)=O)[C@@H](O)[C@@H](O)C1=O InChI=1S/C17H32N2O4/c1-3-4-5-6-7-8-9-10-11-19-12-14(18-13(2)20)15(21)16(22)17(19)23/h14-16,21-22H,3-12H2,1-2H3,(H,18,20)/t14-,15+,16+/m0/s1 ATCKRHPFXUGRBI-ARFHVFGLSA-N 50413906 CHEMBL491743 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413906&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566034 163362930 CHEMBL491743 ZINC49878473 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010711 CCCCCCCCCCN1C[C@@H](O)[C@@H](O)[C@@H](O)C1=O InChI=1S/C15H29NO4/c1-2-3-4-5-6-7-8-9-10-16-11-12(17)13(18)14(19)15(16)20/h12-14,17-19H,2-11H2,1H3/t12-,13-,14-/m1/s1 AJVIZOMIDNOVIX-MGPQQGTHSA-N 50413907 CHEMBL486065 Lysosomal acid glucosylceramidase Homo sapiens 463000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413907&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566033 163362931 CHEMBL486065 ZINC49877680 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010712 CCCN(CCC)CCN1C[C@@H](O)[C@@H](O)[C@H](O)C1=O InChI=1S/C13H26N2O4/c1-3-5-14(6-4-2)7-8-15-9-10(16)11(17)12(18)13(15)19/h10-12,16-18H,3-9H2,1-2H3/t10-,11-,12+/m1/s1 DFPDVHRQVFBIIV-UTUOFQBUSA-N 50413908 CHEMBL488314 Lysosomal acid glucosylceramidase Homo sapiens 253000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413908&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566018 163362932 CHEMBL488314 ZINC40423138 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010713 CCCOCCCCCCN1C[C@@H](O)[C@@H](O)[C@H](O)C1=O InChI=1S/C14H27NO5/c1-2-8-20-9-6-4-3-5-7-15-10-11(16)12(17)13(18)14(15)19/h11-13,16-18H,2-10H2,1H3/t11-,12-,13+/m1/s1 FIFMTBYAVBDNBK-UPJWGTAASA-N 50413909 CHEMBL490715 Lysosomal acid glucosylceramidase Homo sapiens 127000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413909&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566016 163362933 CHEMBL490715 ZINC45506596 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010714 CCCCCCCCCN1C[C@@H](O)[C@@H](O)[C@H](O)C1=O InChI=1S/C14H27NO4/c1-2-3-4-5-6-7-8-9-15-10-11(16)12(17)13(18)14(15)19/h11-13,16-18H,2-10H2,1H3/t11-,12-,13+/m1/s1 HQKWSTDXENDNQF-UPJWGTAASA-N 50413910 CHEMBL444504 Lysosomal acid glucosylceramidase Homo sapiens 102000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413910&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44565995 163362934 CHEMBL444504 ZINC44305909 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010715 CCCCCCCCCCN1C[C@@H](O)[C@@H](O)[C@H](O)C1=O InChI=1S/C15H29NO4/c1-2-3-4-5-6-7-8-9-10-16-11-12(17)13(18)14(19)15(16)20/h12-14,17-19H,2-11H2,1H3/t12-,13-,14+/m1/s1 AJVIZOMIDNOVIX-MCIONIFRSA-N 50413911 CHEMBL449940 Lysosomal acid glucosylceramidase Homo sapiens 46000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413911&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44138544 163362935 CHEMBL449940 ZINC44351003 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010716 OCCCCCCN1C[C@@H](O)[C@@H](O)C1=O InChI=1S/C10H19NO4/c12-6-4-2-1-3-5-11-7-8(13)9(14)10(11)15/h8-9,12-14H,1-7H2/t8-,9-/m1/s1 CEFJNGWQZPZGOX-RKDXNWHRSA-N 50413912 CHEMBL470943 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413912&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566055 163362936 CHEMBL470943 ZINC40950385 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010717 CCCOCCN1C[C@@H](O)[C@@H](O)[C@H](O)C1=O InChI=1S/C10H19NO5/c1-2-4-16-5-3-11-6-7(12)8(13)9(14)10(11)15/h7-9,12-14H,2-6H2,1H3/t7-,8-,9+/m1/s1 LHFCYNOLAKSFMB-HLTSFMKQSA-N 50413913 CHEMBL490716 Lysosomal acid glucosylceramidase Homo sapiens >500000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413913&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44566017 163362937 CHEMBL490716 ZINC45506599 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51010718 CCCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)C1=O InChI=1S/C15H29NO4/c1-2-3-4-5-6-7-8-9-10-16-11-12(17)13(18)14(19)15(16)20/h12-14,17-19H,2-11H2,1H3/t12-,13+,14-/m0/s1 AJVIZOMIDNOVIX-MJBXVCDLSA-N 50413914 CHEMBL492080 Lysosomal acid glucosylceramidase Homo sapiens 295000 ChEMBL 10.1021/jm801506m 10.7270/Q26W9CBW 19397268 Wang, GN; Reinkensmeier, G; Zhang, SW; Zhou, J; Zhang, LR; Zhang, LH; Butters, TD; Ye, XS Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50413914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50413914&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44140356 163362938 CHEMBL492080 ZINC49878479 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522260 C1Cc2ccccc2C[C@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m0/s1 NNXTWWKGCDOEQE-IBGZPJMESA-N 50196514 CHEMBL3950881::US10167270, Example 00159 Lysosomal acid glucosylceramidase Homo sapiens 8.7 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196514&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168030 375977471 CHEMBL3950881 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522261 C(Cc1ccccn1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H17N5/c1-2-9-18-17(8-1)20(23-13-10-16-7-3-4-12-22-16)25-19(24-18)15-6-5-11-21-14-15/h1-9,11-12,14H,10,13H2,(H,23,24,25) XDSFFKXQUALAPV-UHFFFAOYSA-N 50196515 CHEMBL3913022::US10167270, Compound 8f Lysosomal acid glucosylceramidase Homo sapiens 1400 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196515&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9282942 375977472 CHEMBL3913022 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522262 C1CCC(C1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C18H18N4/c1-2-8-14(7-1)20-18-15-9-3-4-10-16(15)21-17(22-18)13-6-5-11-19-12-13/h3-6,9-12,14H,1-2,7-8H2,(H,20,21,22) WRPPYAYLCGHEDY-UHFFFAOYSA-N 50196516 CHEMBL3968279::US10167270, Compound 7c Lysosomal acid glucosylceramidase Homo sapiens 720 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196516&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17391397 375977473 CHEMBL3968279 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522263 FC1(F)CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C19H18F2N4/c20-19(21)9-7-14(8-10-19)23-18-15-5-1-2-6-16(15)24-17(25-18)13-4-3-11-22-12-13/h1-6,11-12,14H,7-10H2,(H,23,24,25) GQSVORBZXSEUJW-UHFFFAOYSA-N 50196517 CHEMBL3980248::US10167270, Compound 6f Lysosomal acid glucosylceramidase Homo sapiens 234 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196517&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168022 375977474 CHEMBL3980248 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522264 C1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C19H20N4/c1-2-8-15(9-3-1)21-19-16-10-4-5-11-17(16)22-18(23-19)14-7-6-12-20-13-14/h4-7,10-13,15H,1-3,8-9H2,(H,21,22,23) VTJDAALCLRKSIX-UHFFFAOYSA-N 50196518 CHEMBL3920301::US10167270, Compound 4 Lysosomal acid glucosylceramidase Homo sapiens 177 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196518&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 873720 375977475 CHEMBL3920301 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522265 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccs1 InChI=1S/C21H17N3S/c1-2-7-15-13-16(12-14(15)6-1)22-20-17-8-3-4-9-18(17)23-21(24-20)19-10-5-11-25-19/h1-11,16H,12-13H2,(H,22,23,24) YIFJXSPQCBCHCI-UHFFFAOYSA-N 50196519 CHEMBL3930102::US10167270, Example 00163::US10501435, Compound 11f Lysosomal acid glucosylceramidase Homo sapiens 8.2 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196519&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168091 375977476 CHEMBL3930102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522266 C1Cc2ccccc2C[C@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m0/s1 NNXTWWKGCDOEQE-IBGZPJMESA-N 50196514 CHEMBL3950881::US10167270, Example 00159 Lysosomal acid glucosylceramidase Homo sapiens 17 7 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196514&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168030 375977471 CHEMBL3950881 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522267 C1CC(C1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C17H16N4/c1-2-9-15-14(8-1)17(19-13-6-3-7-13)21-16(20-15)12-5-4-10-18-11-12/h1-2,4-5,8-11,13H,3,6-7H2,(H,19,20,21) WBKIOFACQKHWCN-UHFFFAOYSA-N 50196520 CHEMBL3944808::US10167270, Compound 7d Lysosomal acid glucosylceramidase Homo sapiens 2840 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196520&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168092 375977477 CHEMBL3944808 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522268 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C23H19N3/c1-2-8-16(9-3-1)22-25-21-13-7-6-12-20(21)23(26-22)24-19-14-17-10-4-5-11-18(17)15-19/h1-13,19H,14-15H2,(H,24,25,26) DCLFPHIXBNDNBF-UHFFFAOYSA-N 50196521 CHEMBL3939100::US10167270, Example 00162::US10501435, Compound 11d Lysosomal acid glucosylceramidase Homo sapiens 11 5 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196521&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168420 375977478 CHEMBL3939100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522269 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccncc1 InChI=1S/C22H18N4/c1-2-6-17-14-18(13-16(17)5-1)24-22-19-7-3-4-8-20(19)25-21(26-22)15-9-11-23-12-10-15/h1-12,18H,13-14H2,(H,24,25,26) CXXZGJGTXABPOP-UHFFFAOYSA-N 50196522 CHEMBL3957610::US10167270, Compound 11e Lysosomal acid glucosylceramidase Homo sapiens 168 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196522&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134154906 375977479 CHEMBL3957610 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522270 C(Cc1cccnc1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H17N5/c1-2-8-18-17(7-1)20(23-12-9-15-5-3-10-21-13-15)25-19(24-18)16-6-4-11-22-14-16/h1-8,10-11,13-14H,9,12H2,(H,23,24,25) UKYOLERGWNZMQS-UHFFFAOYSA-N 50196523 CHEMBL3914158::US10167270, Compound 8g Lysosomal acid glucosylceramidase Homo sapiens 4290 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196523&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 31408646 375977480 CHEMBL3914158 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522271 Cc1ccc(cn1)-c1nc(NC2Cc3ccccc3C2)c2ccccc2n1 InChI=1S/C23H20N4/c1-15-10-11-18(14-24-15)22-26-21-9-5-4-8-20(21)23(27-22)25-19-12-16-6-2-3-7-17(16)13-19/h2-11,14,19H,12-13H2,1H3,(H,25,26,27) SNPORVMVKFFDMI-UHFFFAOYSA-N 50196524 CHEMBL3968646::US10167270, Compound 11c Lysosomal acid glucosylceramidase Homo sapiens 29 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196524&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134150037 375977481 CHEMBL3968646 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522272 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccs1 InChI=1S/C21H17N3S/c1-2-7-15-13-16(12-14(15)6-1)22-20-17-8-3-4-9-18(17)23-21(24-20)19-10-5-11-25-19/h1-11,16H,12-13H2,(H,22,23,24) YIFJXSPQCBCHCI-UHFFFAOYSA-N 50196519 CHEMBL3930102::US10167270, Example 00163::US10501435, Compound 11f Lysosomal acid glucosylceramidase Homo sapiens 13 7 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196519&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168091 375977476 CHEMBL3930102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522273 C1C2CC3CC1CC(C2)(C3)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H24N4/c1-2-6-20-19(5-1)22(26-21(25-20)18-4-3-7-24-14-18)27-23-11-15-8-16(12-23)10-17(9-15)13-23/h1-7,14-17H,8-13H2,(H,25,26,27) LEWAHVWACBZCDA-UHFFFAOYSA-N 50196525 CHEMBL3908863::US10167270, Compound 7f Lysosomal acid glucosylceramidase Homo sapiens 926 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196525&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168100 375977482 CHEMBL3908863 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522274 C1Oc2ccccc2CC1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4O/c1-4-10-20-15(6-1)12-17(14-27-20)24-22-18-8-2-3-9-19(18)25-21(26-22)16-7-5-11-23-13-16/h1-11,13,17H,12,14H2,(H,24,25,26) NMYSKFXCEWTIDV-UHFFFAOYSA-N 50196526 CHEMBL3941104 Lysosomal acid glucosylceramidase Homo sapiens 35 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196526&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134146186 375977483 CHEMBL3941104 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522275 C1Cc2ccccc2C1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-8-17-15(6-1)11-12-20(17)25-22-18-9-3-4-10-19(18)24-21(26-22)16-7-5-13-23-14-16/h1-10,13-14,20H,11-12H2,(H,24,25,26) NHFIHEPUGCTNFM-UHFFFAOYSA-N 50196527 CHEMBL3970658::US10167270, Compound 9e Lysosomal acid glucosylceramidase Homo sapiens 821 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196527&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17518657 375977484 CHEMBL3970658 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522276 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-7-16-13-18(12-15(16)6-1)24-22-19-9-3-4-10-20(19)25-21(26-22)17-8-5-11-23-14-17/h1-11,14,18H,12-13H2,(H,24,25,26) XXCCBJLQMRHXKM-UHFFFAOYSA-N 50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c Lysosomal acid glucosylceramidase Homo sapiens 8.3 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168025 375977485 CHEMBL3923120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522277 C(Cc1ccccc1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H18N4/c1-2-7-16(8-3-1)12-14-23-21-18-10-4-5-11-19(18)24-20(25-21)17-9-6-13-22-15-17/h1-11,13,15H,12,14H2,(H,23,24,25) UWQNTLVHUVARDK-UHFFFAOYSA-N 50033286 CHEMBL544818::Phenethyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine; dihydrochloride::US10167270, Compound 8c Lysosomal acid glucosylceramidase Homo sapiens 97 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033286&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 874599 103941603 CHEMBL544818 ZINC00442667 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522278 C(Nc1nc(nc2ccccc12)-c1cccnc1)c1ccccc1 InChI=1S/C20H16N4/c1-2-7-15(8-3-1)13-22-20-17-10-4-5-11-18(17)23-19(24-20)16-9-6-12-21-14-16/h1-12,14H,13H2,(H,22,23,24) AELMNLIYFALJIR-UHFFFAOYSA-N 50033284 Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine::CHEMBL119841::US10167270, Compound 8b::cid_667555 Lysosomal acid glucosylceramidase Homo sapiens 5770 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033284&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 667555 103941601 CHEMBL119841 ZINC00005903 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522279 C1CC1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C16H14N4/c1-2-6-14-13(5-1)16(18-12-7-8-12)20-15(19-14)11-4-3-9-17-10-11/h1-6,9-10,12H,7-8H2,(H,18,19,20) ZYMFUDCVHZLPBA-UHFFFAOYSA-N 50196529 CHEMBL3979185::US10167270, Compound 7e Lysosomal acid glucosylceramidase Homo sapiens 28070 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196529&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 8080175 375977486 CHEMBL3979185 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522280 C1CCCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-2-4-10-16(9-3-1)22-20-17-11-5-6-12-18(17)23-19(24-20)15-8-7-13-21-14-15/h5-8,11-14,16H,1-4,9-10H2,(H,22,23,24) REYRWOJVPIEDER-UHFFFAOYSA-N 50196530 CHEMBL3974789::US10167270, Compound 7b Lysosomal acid glucosylceramidase Homo sapiens 42 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196530&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2456688 375977487 CHEMBL3974789 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522281 C1CCCC(CCC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-2-4-10-17(11-5-3-1)23-21-18-12-6-7-13-19(18)24-20(25-21)16-9-8-14-22-15-16/h6-9,12-15,17H,1-5,10-11H2,(H,23,24,25) KPHDEGYZCGJLCL-UHFFFAOYSA-N 50196531 CHEMBL3964444::US10167270, Compound 7a Lysosomal acid glucosylceramidase Homo sapiens 27 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196531&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17546054 375977488 CHEMBL3964444 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522282 CC(C)N1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H25N5/c1-15(2)26-12-9-17(10-13-26)23-21-18-7-3-4-8-19(18)24-20(25-21)16-6-5-11-22-14-16/h3-8,11,14-15,17H,9-10,12-13H2,1-2H3,(H,23,24,25) ZAMRXVJIXGJERV-UHFFFAOYSA-N 50196532 CHEMBL3912910::US10167270, Compound 6j Lysosomal acid glucosylceramidase Homo sapiens 33210 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196532&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16355345 375977489 CHEMBL3912910 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522283 CC1(C)CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-21(2)11-9-16(10-12-21)23-20-17-7-3-4-8-18(17)24-19(25-20)15-6-5-13-22-14-15/h3-8,13-14,16H,9-12H2,1-2H3,(H,23,24,25) HSPJNLGHEQYSQA-UHFFFAOYSA-N 50196533 CHEMBL3894465::US10167270, Compound 6e Lysosomal acid glucosylceramidase Homo sapiens 431 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196533&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168446 375977490 CHEMBL3894465 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522284 C[C@H]1CC[C@@H](CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-14-8-10-16(11-9-14)22-20-17-6-2-3-7-18(17)23-19(24-20)15-5-4-12-21-13-15/h2-7,12-14,16H,8-11H2,1H3,(H,22,23,24)/t14-,16- ZIBKSPGRIZLUEF-KOMQPUFPSA-N 50196534 CHEMBL3956777 Lysosomal acid glucosylceramidase Homo sapiens 20 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196534&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4965949 375977491 CHEMBL3956777 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522285 CC1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-14-8-10-16(11-9-14)22-20-17-6-2-3-7-18(17)23-19(24-20)15-5-4-12-21-13-15/h2-7,12-14,16H,8-11H2,1H3,(H,22,23,24) ZIBKSPGRIZLUEF-UHFFFAOYSA-N 50196535 CHEMBL3948124::US10167270, Compound 6a Lysosomal acid glucosylceramidase Homo sapiens 56 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196535&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4965949 375977492 CHEMBL3948124 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522286 Cc1ccncc1-c1nc(NC2Cc3ccccc3C2)c2ccccc2n1 InChI=1S/C23H20N4/c1-15-10-11-24-14-20(15)23-26-21-9-5-4-8-19(21)22(27-23)25-18-12-16-6-2-3-7-17(16)13-18/h2-11,14,18H,12-13H2,1H3,(H,25,26,27) IZELJCTXEFPJGK-UHFFFAOYSA-N 50196536 CHEMBL3906252::US10167270, Compound 11a Lysosomal acid glucosylceramidase Homo sapiens 122 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196536&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134134697 375977493 CHEMBL3906252 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522287 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C23H19N3/c1-2-8-16(9-3-1)22-25-21-13-7-6-12-20(21)23(26-22)24-19-14-17-10-4-5-11-18(17)15-19/h1-13,19H,14-15H2,(H,24,25,26) DCLFPHIXBNDNBF-UHFFFAOYSA-N 50196521 CHEMBL3939100::US10167270, Example 00162::US10501435, Compound 11d Lysosomal acid glucosylceramidase Homo sapiens 6.5 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196521&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168420 375977478 CHEMBL3939100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522288 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccco1 InChI=1S/C21H17N3O/c1-2-7-15-13-16(12-14(15)6-1)22-20-17-8-3-4-9-18(17)23-21(24-20)19-10-5-11-25-19/h1-11,16H,12-13H2,(H,22,23,24) NZSRNECXKGBZCA-UHFFFAOYSA-N 50196610 CHEMBL3956552::US10167270, Compound 11h Lysosomal acid glucosylceramidase Homo sapiens 21 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196610&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134143870 104078326 CHEMBL3956552 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522289 C1Cc2ccccc2C[C@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m0/s1 NNXTWWKGCDOEQE-IBGZPJMESA-N 50196514 CHEMBL3950881::US10167270, Example 00159 Lysosomal acid glucosylceramidase Homo sapiens 22 5 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196514&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168030 375977471 CHEMBL3950881 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522290 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 30 5 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522291 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 19 7 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522292 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C23H19N3/c1-2-8-16(9-3-1)22-25-21-13-7-6-12-20(21)23(26-22)24-19-14-17-10-4-5-11-18(17)15-19/h1-13,19H,14-15H2,(H,24,25,26) DCLFPHIXBNDNBF-UHFFFAOYSA-N 50196521 CHEMBL3939100::US10167270, Example 00162::US10501435, Compound 11d Lysosomal acid glucosylceramidase Homo sapiens 9.4 7 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196521&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168420 375977478 CHEMBL3939100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522293 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccsc1 InChI=1S/C21H17N3S/c1-2-6-15-12-17(11-14(15)5-1)22-21-18-7-3-4-8-19(18)23-20(24-21)16-9-10-25-13-16/h1-10,13,17H,11-12H2,(H,22,23,24) JCDASFBLAYXAIQ-UHFFFAOYSA-N 50196623 CHEMBL3976182::US10167270, Example 00164::US10501435, Compound 11g Lysosomal acid glucosylceramidase Homo sapiens 6.6 7 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196623&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168348 375977495 CHEMBL3976182 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522294 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccsc1 InChI=1S/C21H17N3S/c1-2-6-15-12-17(11-14(15)5-1)22-21-18-7-3-4-8-19(18)23-20(24-21)16-9-10-25-13-16/h1-10,13,17H,11-12H2,(H,22,23,24) JCDASFBLAYXAIQ-UHFFFAOYSA-N 50196623 CHEMBL3976182::US10167270, Example 00164::US10501435, Compound 11g Lysosomal acid glucosylceramidase Homo sapiens 8.9 5 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196623&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168348 375977495 CHEMBL3976182 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522295 C(Nc1nc(nc2ccccc12)-c1cccnc1)C1CCCCC1 InChI=1S/C20H22N4/c1-2-7-15(8-3-1)13-22-20-17-10-4-5-11-18(17)23-19(24-20)16-9-6-12-21-14-16/h4-6,9-12,14-15H,1-3,7-8,13H2,(H,22,23,24) VADSISQHMHUCOP-UHFFFAOYSA-N 50196624 CHEMBL3963682::US10167270, Compound 7h Lysosomal acid glucosylceramidase Homo sapiens 405 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196624&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 21808535 375977496 CHEMBL3963682 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522296 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 9.9 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522297 C(N1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1)c1ccccc1 InChI=1S/C25H25N5/c1-2-7-19(8-3-1)18-30-15-12-21(13-16-30)27-25-22-10-4-5-11-23(22)28-24(29-25)20-9-6-14-26-17-20/h1-11,14,17,21H,12-13,15-16,18H2,(H,27,28,29) FPSNRFFFQDOELT-UHFFFAOYSA-N 50196625 CHEMBL1405704::US10167270, Compound 6k Lysosomal acid glucosylceramidase Homo sapiens 36070 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196625&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4882879 375977497 CHEMBL1405704 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522298 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-7-16-13-18(12-15(16)6-1)24-22-19-9-3-4-10-20(19)25-21(26-22)17-8-5-11-23-14-17/h1-11,14,18H,12-13H2,(H,24,25,26) XXCCBJLQMRHXKM-UHFFFAOYSA-N 50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c Lysosomal acid glucosylceramidase Homo sapiens 26 5 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168025 375977485 CHEMBL3923120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522299 C(CCc1ccccc1)CNc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H22N4/c1-2-9-18(10-3-1)11-6-7-16-25-23-20-13-4-5-14-21(20)26-22(27-23)19-12-8-15-24-17-19/h1-5,8-10,12-15,17H,6-7,11,16H2,(H,25,26,27) LXPSTEYVBFGHEM-UHFFFAOYSA-N 50196626 CHEMBL3972062::US10167270, Compound 8e Lysosomal acid glucosylceramidase Homo sapiens 1280 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196626&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168418 375977498 CHEMBL3972062 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522300 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccs1 InChI=1S/C21H17N3S/c1-2-7-15-13-16(12-14(15)6-1)22-20-17-8-3-4-9-18(17)23-21(24-20)19-10-5-11-25-19/h1-11,16H,12-13H2,(H,22,23,24) YIFJXSPQCBCHCI-UHFFFAOYSA-N 50196519 CHEMBL3930102::US10167270, Example 00163::US10501435, Compound 11f Lysosomal acid glucosylceramidase Homo sapiens 14 5 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196519&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168091 375977476 CHEMBL3930102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522301 CCC1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-2-15-9-11-17(12-10-15)23-21-18-7-3-4-8-19(18)24-20(25-21)16-6-5-13-22-14-16/h3-8,13-15,17H,2,9-12H2,1H3,(H,23,24,25) NSUPJZHPKLIZHG-UHFFFAOYSA-N 50196627 CHEMBL3929224::US10167270, Compound 6b Lysosomal acid glucosylceramidase Homo sapiens 126 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196627&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168443 375977499 CHEMBL3929224 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522302 C1CC(Nc2nc(nc3ccccc23)-c2cccnc2)c2ccccc2C1 InChI=1S/C23H20N4/c1-2-10-18-16(7-1)8-5-13-20(18)26-23-19-11-3-4-12-21(19)25-22(27-23)17-9-6-14-24-15-17/h1-4,6-7,9-12,14-15,20H,5,8,13H2,(H,25,26,27) XGFDEYBZTPSJCH-UHFFFAOYSA-N 50196628 CHEMBL3932095::US10167270, Compound 9d Lysosomal acid glucosylceramidase Homo sapiens 872 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196628&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168445 375977500 CHEMBL3932095 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522303 C(CNc1nc(nc2ccccc12)-c1cccnc1)Cc1ccccc1 InChI=1S/C22H20N4/c1-2-8-17(9-3-1)10-6-15-24-22-19-12-4-5-13-20(19)25-21(26-22)18-11-7-14-23-16-18/h1-5,7-9,11-14,16H,6,10,15H2,(H,24,25,26) KNPAHIAFSKZRIB-UHFFFAOYSA-N 50196630 CHEMBL3942452::US10167270, Compound 8d Lysosomal acid glucosylceramidase Homo sapiens 1530 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196630&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168417 375977501 CHEMBL3942452 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522304 C(CC1CCCCC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-2-7-16(8-3-1)12-14-23-21-18-10-4-5-11-19(18)24-20(25-21)17-9-6-13-22-15-17/h4-6,9-11,13,15-16H,1-3,7-8,12,14H2,(H,23,24,25) HDBYPZURDNCVJI-UHFFFAOYSA-N 50196631 CHEMBL3898722::US10167270, Compound 7i Lysosomal acid glucosylceramidase Homo sapiens 857 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196631&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168444 375977502 CHEMBL3898722 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522305 C1COCC(C1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C18H18N4O/c1-2-8-16-15(7-1)18(20-14-6-4-10-23-12-14)22-17(21-16)13-5-3-9-19-11-13/h1-3,5,7-9,11,14H,4,6,10,12H2,(H,20,21,22) NSTBSEQCWALGQL-UHFFFAOYSA-N 50196632 CHEMBL3921895::US10167270, Compound 6h Lysosomal acid glucosylceramidase Homo sapiens 891 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196632&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168199 375977503 CHEMBL3921895 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522307 Cc1cncc(c1)-c1nc(NC2Cc3ccccc3C2)c2ccccc2n1 InChI=1S/C23H20N4/c1-15-10-18(14-24-13-15)22-26-21-9-5-4-8-20(21)23(27-22)25-19-11-16-6-2-3-7-17(16)12-19/h2-10,13-14,19H,11-12H2,1H3,(H,25,26,27) SKNLOHJCCVGXLC-UHFFFAOYSA-N 50196634 CHEMBL3976949::US10167270, Compound 11b Lysosomal acid glucosylceramidase Homo sapiens 13 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196634&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134152584 375977505 CHEMBL3976949 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522308 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccsc1 InChI=1S/C21H17N3S/c1-2-6-15-12-17(11-14(15)5-1)22-21-18-7-3-4-8-19(18)23-20(24-21)16-9-10-25-13-16/h1-10,13,17H,11-12H2,(H,22,23,24) JCDASFBLAYXAIQ-UHFFFAOYSA-N 50196623 CHEMBL3976182::US10167270, Example 00164::US10501435, Compound 11g Lysosomal acid glucosylceramidase Homo sapiens 5.2 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196623&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168348 375977495 CHEMBL3976182 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522306 COC1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4O/c1-25-16-10-8-15(9-11-16)22-20-17-6-2-3-7-18(17)23-19(24-20)14-5-4-12-21-13-14/h2-7,12-13,15-16H,8-11H2,1H3,(H,22,23,24) KHUIQQWXJGLXHU-UHFFFAOYSA-N 50196633 CHEMBL3965871::US10167270, Compound 6d Lysosomal acid glucosylceramidase Homo sapiens 251 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196633&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168347 375977504 CHEMBL3965871 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522309 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-7-16-13-18(12-15(16)6-1)24-22-19-9-3-4-10-20(19)25-21(26-22)17-8-5-11-23-14-17/h1-11,14,18H,12-13H2,(H,24,25,26) XXCCBJLQMRHXKM-UHFFFAOYSA-N 50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c Lysosomal acid glucosylceramidase Homo sapiens 13 7 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168025 375977485 CHEMBL3923120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50522310 C1CC2CC1CC2Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H20N4/c1-2-6-17-16(5-1)20(23-18-11-13-7-8-14(18)10-13)24-19(22-17)15-4-3-9-21-12-15/h1-6,9,12-14,18H,7-8,10-11H2,(H,22,23,24) FPKKVYLMXWIWLV-UHFFFAOYSA-N 50196635 CHEMBL3970989::US10167270, Compound 7g Lysosomal acid glucosylceramidase Homo sapiens 282 5.9 ChEMBL 10.1021/acs.jmedchem.6b00930 10.7270/Q2QF8VV6 27598312 Zheng, J; Chen, L; Schwake, M; Silverman, RB; Krainc, D Northwestern University Feinberg School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196635&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168197 375977506 CHEMBL3970989 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523751 CCCCCCCC\N=C1\SC[C@@H]2[C@@H](O)[C@H](O)CCN12 InChI=1S/C15H28N2O2S/c1-2-3-4-5-6-7-9-16-15-17-10-8-13(18)14(19)12(17)11-20-15/h12-14,18-19H,2-11H2,1H3/b16-15+/t12-,13-,14-/m1/s1 YRQXRMFWPPJGMS-JRCSOJPKSA-N 50197866 CHEMBL3937138 Lysosomal acid glucosylceramidase Homo sapiens 115000 5 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197866&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134149179 375978045 CHEMBL3937138 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523752 CCCCCCCC\N=C1\SC[C@@H]2[C@H](O)[C@H](O)CN12 InChI=1S/C14H26N2O2S/c1-2-3-4-5-6-7-8-15-14-16-9-12(17)13(18)11(16)10-19-14/h11-13,17-18H,2-10H2,1H3/b15-14+/t11-,12-,13+/m1/s1 UZNSOHBBKVVYLF-QHRPLHADSA-N 50197867 CHEMBL3980439 Lysosomal acid glucosylceramidase Homo sapiens 76000 5 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197867&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134157313 375978046 CHEMBL3980439 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523753 CCCCCCCCNC(=S)N1CC[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H30N2O3S/c1-2-3-4-5-6-7-9-16-15(21)17-10-8-13(19)14(20)12(17)11-18/h12-14,18-20H,2-11H2,1H3,(H,16,21)/t12-,13-,14-/m1/s1 VPTZLDMPPSATRC-MGPQQGTHSA-N 50197868 CHEMBL3931823 Lysosomal acid glucosylceramidase Homo sapiens >1000000 7 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197868&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134138587 375978047 CHEMBL3931823 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523754 OCCCCCCCCCCCCCCCC\N=C1\SC[C@@H]2[C@@H](O)[C@H](O)CCN12 InChI=1S/C23H44N2O3S/c26-18-14-12-10-8-6-4-2-1-3-5-7-9-11-13-16-24-23-25-17-15-21(27)22(28)20(25)19-29-23/h20-22,26-28H,1-19H2/b24-23+/t20-,21-,22-/m1/s1 DUZVOQYLKHKGJO-MKTIXIMESA-N 50197869 CHEMBL3909220 Lysosomal acid glucosylceramidase Homo sapiens 6800 7 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197869&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134131863 375978048 CHEMBL3909220 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523755 CCCCCCCC\N=C1\SC[C@H]2[C@H](O)[C@@H](O)CN12 InChI=1S/C14H26N2O2S/c1-2-3-4-5-6-7-8-15-14-16-9-12(17)13(18)11(16)10-19-14/h11-13,17-18H,2-10H2,1H3/b15-14+/t11-,12-,13-/m0/s1 UZNSOHBBKVVYLF-VEBXKOBCSA-N 50197870 CHEMBL3950752 Lysosomal acid glucosylceramidase Homo sapiens 8600 7 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197870&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134148190 375978049 CHEMBL3950752 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523756 OCCCCCCCCCCCCCCCC\N=C1\SC[C@H]2[C@H](O)[C@@H](O)CN12 InChI=1S/C22H42N2O3S/c25-16-14-12-10-8-6-4-2-1-3-5-7-9-11-13-15-23-22-24-17-20(26)21(27)19(24)18-28-22/h19-21,25-27H,1-18H2/b23-22+/t19-,20-,21-/m0/s1 FAQKUJNDGVUWBQ-HASDJUPYSA-N 50197871 CHEMBL3979715 Lysosomal acid glucosylceramidase Homo sapiens 4100 7 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197871&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134152833 375978050 CHEMBL3979715 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523757 OCCCCCCCCCCCCCCCC\N=C1\SC[C@@H]2[C@@H](O)[C@H](O)CCN12 InChI=1S/C23H44N2O3S/c26-18-14-12-10-8-6-4-2-1-3-5-7-9-11-13-16-24-23-25-17-15-21(27)22(28)20(25)19-29-23/h20-22,26-28H,1-19H2/b24-23+/t20-,21-,22-/m1/s1 DUZVOQYLKHKGJO-MKTIXIMESA-N 50197869 CHEMBL3909220 Lysosomal acid glucosylceramidase Homo sapiens 56000 5 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197869&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134131863 375978048 CHEMBL3909220 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523758 CCCCCCCCNC(=S)N1C[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C14H28N2O3S/c1-2-3-4-5-6-7-8-15-14(20)16-9-12(18)13(19)11(16)10-17/h11-13,17-19H,2-10H2,1H3,(H,15,20)/t11-,12-,13-/m1/s1 WJSUEMDFGRFGCQ-JHJVBQTASA-N 50197872 CHEMBL3953477 Lysosomal acid glucosylceramidase Homo sapiens >1000000 5 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197872&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134144115 375978051 CHEMBL3953477 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523759 OCCCCCCCCCCCCCCCC\N=C1\SC[C@@H]2[C@H](O)[C@H](O)CN12 InChI=1S/C22H42N2O3S/c25-16-14-12-10-8-6-4-2-1-3-5-7-9-11-13-15-23-22-24-17-20(26)21(27)19(24)18-28-22/h19-21,25-27H,1-18H2/b23-22+/t19-,20-,21+/m1/s1 FAQKUJNDGVUWBQ-ALXWBHHPSA-N 50197873 CHEMBL3974420 Lysosomal acid glucosylceramidase Homo sapiens 55000 5 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197873&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134154157 375978052 CHEMBL3974420 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523760 CCCCCCCCNC(=S)N1C[C@H](O)[C@@H](O)[C@@H]1CO InChI=1S/C14H28N2O3S/c1-2-3-4-5-6-7-8-15-14(20)16-9-12(18)13(19)11(16)10-17/h11-13,17-19H,2-10H2,1H3,(H,15,20)/t11-,12-,13-/m0/s1 WJSUEMDFGRFGCQ-AVGNSLFASA-N 50197874 CHEMBL3933048 Lysosomal acid glucosylceramidase Homo sapiens 645000 5 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197874&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134137830 375978053 CHEMBL3933048 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523761 OCCCCCCCCCCCCCCCC\N=C1\SC[C@H]2[C@H](O)[C@@H](O)CN12 InChI=1S/C22H42N2O3S/c25-16-14-12-10-8-6-4-2-1-3-5-7-9-11-13-15-23-22-24-17-20(26)21(27)19(24)18-28-22/h19-21,25-27H,1-18H2/b23-22+/t19-,20-,21-/m0/s1 FAQKUJNDGVUWBQ-HASDJUPYSA-N 50197871 CHEMBL3979715 Lysosomal acid glucosylceramidase Homo sapiens 40000 5 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197871&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134152833 375978050 CHEMBL3979715 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523762 CCCCCCCCNC(=S)N1C[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C14H28N2O3S/c1-2-3-4-5-6-7-8-15-14(20)16-9-12(18)13(19)11(16)10-17/h11-13,17-19H,2-10H2,1H3,(H,15,20)/t11-,12-,13-/m1/s1 WJSUEMDFGRFGCQ-JHJVBQTASA-N 50197872 CHEMBL3953477 Lysosomal acid glucosylceramidase Homo sapiens 788000 7 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197872&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134144115 375978051 CHEMBL3953477 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523765 CCCCCCCC\N=C1\SC[C@@H]2[C@@H](O)[C@H](O)CCN12 InChI=1S/C15H28N2O2S/c1-2-3-4-5-6-7-9-16-15-17-10-8-13(18)14(19)12(17)11-20-15/h12-14,18-19H,2-11H2,1H3/b16-15+/t12-,13-,14-/m1/s1 YRQXRMFWPPJGMS-JRCSOJPKSA-N 50197866 CHEMBL3937138 Lysosomal acid glucosylceramidase Homo sapiens 12400 7 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197866&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134149179 375978045 CHEMBL3937138 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523766 OCCCCCCCCCCCCCCCC\N=C1\SC[C@@H]2[C@H](O)[C@H](O)CN12 InChI=1S/C22H42N2O3S/c25-16-14-12-10-8-6-4-2-1-3-5-7-9-11-13-15-23-22-24-17-20(26)21(27)19(24)18-28-22/h19-21,25-27H,1-18H2/b23-22+/t19-,20-,21+/m1/s1 FAQKUJNDGVUWBQ-ALXWBHHPSA-N 50197873 CHEMBL3974420 Lysosomal acid glucosylceramidase Homo sapiens 4900 7 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197873&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134154157 375978052 CHEMBL3974420 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523767 CCCCCCCCNC(=S)N1CC[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H30N2O3S/c1-2-3-4-5-6-7-9-16-15(21)17-10-8-13(19)14(20)12(17)11-18/h12-14,18-20H,2-11H2,1H3,(H,16,21)/t12-,13-,14-/m1/s1 VPTZLDMPPSATRC-MGPQQGTHSA-N 50197868 CHEMBL3931823 Lysosomal acid glucosylceramidase Homo sapiens >1000000 5 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197868&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134138587 375978047 CHEMBL3931823 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523768 CCCCCCCC\N=C1\SC[C@H]2[C@H](O)[C@@H](O)CN12 InChI=1S/C14H26N2O2S/c1-2-3-4-5-6-7-8-15-14-16-9-12(17)13(18)11(16)10-19-14/h11-13,17-18H,2-10H2,1H3/b15-14+/t11-,12-,13-/m0/s1 UZNSOHBBKVVYLF-VEBXKOBCSA-N 50197870 CHEMBL3950752 Lysosomal acid glucosylceramidase Homo sapiens 92000 5 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197870&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134148190 375978049 CHEMBL3950752 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523769 CCCCCCCC\N=C1\SC[C@@H]2[C@H](O)[C@H](O)CN12 InChI=1S/C14H26N2O2S/c1-2-3-4-5-6-7-8-15-14-16-9-12(17)13(18)11(16)10-19-14/h11-13,17-18H,2-10H2,1H3/b15-14+/t11-,12-,13+/m1/s1 UZNSOHBBKVVYLF-QHRPLHADSA-N 50197867 CHEMBL3980439 Lysosomal acid glucosylceramidase Homo sapiens 7300 7 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197867&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134157313 375978046 CHEMBL3980439 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50523770 CCCCCCCCNC(=S)N1C[C@H](O)[C@@H](O)[C@@H]1CO InChI=1S/C14H28N2O3S/c1-2-3-4-5-6-7-8-15-14(20)16-9-12(18)13(19)11(16)10-17/h11-13,17-19H,2-10H2,1H3,(H,15,20)/t11-,12-,13-/m0/s1 WJSUEMDFGRFGCQ-AVGNSLFASA-N 50197874 CHEMBL3933048 Lysosomal acid glucosylceramidase Homo sapiens 121000 7 ChEMBL 10.1016/j.ejmech.2015.08.038 10.7270/Q2FT8P07 26361824 Mena-Barragán, T; García-Moreno, MI; Nanba, E; Higaki, K; Concia, AL; Clapés, P; García Fernández, JM; Ortiz Mellet, C University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197874&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134137830 375978053 CHEMBL3933048 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015734 O[C@H]1[C@H](O)[C@@H](O)[C@H](NCc2cn(CCc3ccccc3)nn2)[C@@H](O)[C@@H]1O InChI=1S/C17H24N4O5/c22-13-12(14(23)16(25)17(26)15(13)24)18-8-11-9-21(20-19-11)7-6-10-4-2-1-3-5-10/h1-5,9,12-18,22-26H,6-8H2/t12-,13-,14+,15+,16-,17- YAYXNORBGXQXFG-ZDVFKUJDSA-N 50318556 (1R,2S,3r,4R,5S,6s)-6-[(1-Phenethyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1082491 Lysosomal acid glucosylceramidase Homo sapiens 10715.19 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318556&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867533 104152917 CHEMBL1082491 ZINC49034581 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015735 CCCOCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C18H34N4O6/c1-2-8-28-9-6-4-3-5-7-22-11-12(20-21-22)10-19-13-14(23)16(25)18(27)17(26)15(13)24/h11,13-19,23-27H,2-10H2,1H3/t13-,14-,15+,16+,17-,18- FLUOEQUIGPEGGG-WKTMMLQWSA-N 50318558 (1R,2S,3r,4R,5S,6s)-6-((1-(6-propoxyhexyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1086533 Lysosomal acid glucosylceramidase Homo sapiens 13803.84 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318558&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867532 104152919 CHEMBL1086533 ZINC49049727 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015736 CCCCCCCCCCCn1cc(CCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C21H40N4O5/c1-2-3-4-5-6-7-8-9-10-13-25-14-15(23-24-25)11-12-22-16-17(26)19(28)21(30)20(29)18(16)27/h14,16-22,26-30H,2-13H2,1H3/t16-,17-,18+,19+,20-,21- HDMAMPJZZMETIV-XLGNRPJKSA-N 50318555 (1R,2S,3r,4R,5S,6s)-6-[2-(1-Undecyl-1H-1,2,3-triazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085633 Lysosomal acid glucosylceramidase Homo sapiens 25703.96 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318555&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867664 104152916 CHEMBL1085633 ZINC49793634 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015737 CCCCCCCCn1cc(CCCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O5/c1-2-3-4-5-6-7-11-23-12-13(21-22-23)9-8-10-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- WNRYFPGBHSMMSQ-OXHPVDPFSA-N 50318554 (1R,2S,3r,4R,5S,6s)-6-(3-(1-octyl-1H-1,2,3-triazol-4-yl)propylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085130 Lysosomal acid glucosylceramidase Homo sapiens 35481.34 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318554&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867666 104152915 CHEMBL1085130 ZINC49793241 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015738 CCCCCCCCCn1cc(CCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O5/c1-2-3-4-5-6-7-8-11-23-12-13(21-22-23)9-10-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- GJHJPNQJJDDGMK-OXHPVDPFSA-N 50318553 (1R,2S,3r,4R,5S,6s)-6-[2-(1-Nonyl-1H-1,2,3-triazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085632 Lysosomal acid glucosylceramidase Homo sapiens 44668.36 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318553&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867663 104152914 CHEMBL1085632 ZINC49777203 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015739 CCCCCCCCn1cc(CCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C18H34N4O5/c1-2-3-4-5-6-7-10-22-11-12(20-21-22)8-9-19-13-14(23)16(25)18(27)17(26)15(13)24/h11,13-19,23-27H,2-10H2,1H3/t13-,14-,15+,16+,17-,18- DDVJOAOFJIEZRH-WKTMMLQWSA-N 50318552 (1R,2S,3r,4R,5S,6s)-6-[2-(1-Octyl-1H-1,2,3-triazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085631 Lysosomal acid glucosylceramidase Homo sapiens 165958.69 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318552&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867662 104152913 CHEMBL1085631 ZINC49777202 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015740 CCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C13H24N4O5/c1-2-3-4-17-6-7(15-16-17)5-14-8-9(18)11(20)13(22)12(21)10(8)19/h6,8-14,18-22H,2-5H2,1H3/t8-,9-,10+,11+,12-,13- NQRJFRVZMYWOAY-XESFAPMISA-N 50318551 (1R,2S,3r,4R,5S,6s)-6-[(1-Butyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085391 Lysosomal acid glucosylceramidase Homo sapiens 177827.94 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318551&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867403 104152912 CHEMBL1085391 ZINC49109651 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015741 CCCCCCn1cc(CCCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C17H32N4O5/c1-2-3-4-5-9-21-10-11(19-20-21)7-6-8-18-12-13(22)15(24)17(26)16(25)14(12)23/h10,12-18,22-26H,2-9H2,1H3/t12-,13-,14+,15+,16-,17- SPFGFLKJRLUZKI-ZDVFKUJDSA-N 50318550 (1R,2S,3r,4R,5S,6s)-6-(3-(1-hexyl-1H-1,2,3-triazol-4-yl)propylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085859 Lysosomal acid glucosylceramidase Homo sapiens 257039.58 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318550&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867665 104152911 CHEMBL1085859 ZINC49048734 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015742 CCCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C21H40N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-25-14-15(23-24-25)13-22-16-17(26)19(28)21(30)20(29)18(16)27/h14,16-22,26-30H,2-13H2,1H3/t16-,17-,18+,19+,20-,21- BNEBWGRZFSZRAG-XLGNRPJKSA-N 50318564 (1R,2S,3r,4R,5S,6s)-6-((1-dodecyl-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1084109 Lysosomal acid glucosylceramidase Homo sapiens 30.2 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318564&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867530 104152925 CHEMBL1084109 ZINC49775755 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015743 CCCCCCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C23H44N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-27-16-17(25-26-27)15-24-18-19(28)21(30)23(32)22(31)20(18)29/h16,18-24,28-32H,2-15H2,1H3/t18-,19-,20+,21+,22-,23- NQJWAXBXRCRIRR-FPDSAVIVSA-N 50318563 (1R,2S,3r,4R,5S,6s)-6-[(1-Tetradecyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1086532 Lysosomal acid glucosylceramidase Homo sapiens 89.13 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318563&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867531 104152924 CHEMBL1086532 ZINC49777660 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015744 CCCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C19H36N4O5/c1-2-3-4-5-6-7-8-9-10-23-12-13(21-22-23)11-20-14-15(24)17(26)19(28)18(27)16(14)25/h12,14-20,24-28H,2-11H2,1H3/t14-,15-,16+,17+,18-,19- DCJWZIGHKBTFDW-OXHPVDPFSA-N 50318562 (1R,2S,3r,4R,5S,6s)-6-[(1-Decyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1082596 Lysosomal acid glucosylceramidase Homo sapiens 93.33 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318562&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867529 104152923 CHEMBL1082596 ZINC49777498 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015745 CCCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C18H34N4O5/c1-2-3-4-5-6-7-8-9-22-11-12(20-21-22)10-19-13-14(23)16(25)18(27)17(26)15(13)24/h11,13-19,23-27H,2-10H2,1H3/t13-,14-,15+,16+,17-,18- HXLITFAGQOAVKE-WKTMMLQWSA-N 50318561 (1R,2S,3r,4R,5S,6s)-6-[(1-Nonyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085393 Lysosomal acid glucosylceramidase Homo sapiens 223.87 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318561&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867528 104152922 CHEMBL1085393 ZINC49777327 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015746 CCCCCCCCn1cc(CN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C17H32N4O5/c1-2-3-4-5-6-7-8-21-10-11(19-20-21)9-18-12-13(22)15(24)17(26)16(25)14(12)23/h10,12-18,22-26H,2-9H2,1H3/t12-,13-,14+,15+,16-,17- GOWXONIFDQHALJ-ZDVFKUJDSA-N 50318559 (1R,2S,3r,4R,5S,6s)-6-[(1-Octyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol::CHEMBL1085392 Lysosomal acid glucosylceramidase Homo sapiens 1047.13 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318559&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867661 104152920 CHEMBL1085392 ZINC49777326 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51015747 CCCCCCCCCCn1cc(CCCN[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]2O)nn1 InChI=1S/C21H40N4O5/c1-2-3-4-5-6-7-8-9-13-25-14-15(23-24-25)11-10-12-22-16-17(26)19(28)21(30)20(29)18(16)27/h14,16-22,26-30H,2-13H2,1H3/t16-,17-,18+,19+,20-,21- WESSLVVPBLSCJX-XLGNRPJKSA-N 50318557 (1R,2S,3r,4R,5S,6s)-6-(3-(1-decyl-1H-1,2,3-triazol-4-yl)propylamino)cyclohexane-1,2,3,4,5-pentaol::CHEMBL1083794 Lysosomal acid glucosylceramidase Homo sapiens 3467.37 ChEMBL 10.1021/jm100198t 10.7270/Q2VH5PS1 20557054 Diaz, L; Bujons, J; Casas, J; Llebaria, A; Delgado, A Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318557&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 46867950 104152918 CHEMBL1083794 ZINC49777055 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51073110 COc1ccc2CCC(CC(=O)NCCCCN3C[C@H](O)[C@@H](O)[C@H](O)[C@H]3CO)c2c1 InChI=1S/C22H34N2O6/c1-30-16-7-6-14-4-5-15(17(14)11-16)10-20(27)23-8-2-3-9-24-12-19(26)22(29)21(28)18(24)13-25/h6-7,11,15,18-19,21-22,25-26,28-29H,2-5,8-10,12-13H2,1H3,(H,23,27)/t15?,18-,19+,21-,22-/m1/s1 XABGQJPIXOCGOY-PNEFNFSBSA-N 50438748 CHEMBL2414879 Lysosomal acid glucosylceramidase Homo sapiens 1100 ChEMBL 10.1016/j.bmc.2013.06.054 10.7270/Q2XG9SJX 23880081 Cheng, WC; Weng, CY; Yun, WY; Chang, SY; Lin, YC; Tsai, FJ; Huang, FY; Chen, YR Genomics Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50438748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50438748&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 71770658 175451065 CHEMBL2414879 ZINC96282605 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51073111 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)N1CCCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1 InChI=1S/C31H38N2O5/c34-21-26-29(37)30(38)27(22-35)33(26)19-11-10-18-32-28(36)20-31(23-12-4-1-5-13-23,24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-9,12-17,26-27,29-30,34-35,37-38H,10-11,18-22H2,(H,32,36)/t26-,27-,29-,30-/m1/s1 BGVTUNXMBJSZRS-XQQPTAJKSA-N 50438749 CHEMBL2414888 Lysosomal acid glucosylceramidase Homo sapiens 4100 ChEMBL 10.1016/j.bmc.2013.06.054 10.7270/Q2XG9SJX 23880081 Cheng, WC; Weng, CY; Yun, WY; Chang, SY; Lin, YC; Tsai, FJ; Huang, FY; Chen, YR Genomics Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50438749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50438749&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 71770782 175451066 CHEMBL2414888 ZINC96282606 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51073112 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 1300 ChEMBL 10.1016/j.bmc.2013.06.054 10.7270/Q2XG9SJX 23880081 Cheng, WC; Weng, CY; Yun, WY; Chang, SY; Lin, YC; Tsai, FJ; Huang, FY; Chen, YR Genomics Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51073113 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCNC(=O)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C20H26F6N2O5/c21-19(22,23)12-5-11(6-13(8-12)20(24,25)26)7-16(31)27-3-1-2-4-28-9-15(30)18(33)17(32)14(28)10-29/h5-6,8,14-15,17-18,29-30,32-33H,1-4,7,9-10H2,(H,27,31)/t14-,15+,17-,18-/m1/s1 YDYYFEGGTZWTEO-CYGHRXIMSA-N 50438750 CHEMBL2414884 Lysosomal acid glucosylceramidase Homo sapiens 71 ChEMBL 10.1016/j.bmc.2013.06.054 10.7270/Q2XG9SJX 23880081 Cheng, WC; Weng, CY; Yun, WY; Chang, SY; Lin, YC; Tsai, FJ; Huang, FY; Chen, YR Genomics Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50438750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50438750&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 71770663 175451067 CHEMBL2414884 ZINC96282607 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51073114 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCNC(=O)COc1ccc(Cl)c(Cl)c1 InChI=1S/C18H26Cl2N2O6/c19-12-4-3-11(7-13(12)20)28-10-16(25)21-5-1-2-6-22-8-15(24)18(27)17(26)14(22)9-23/h3-4,7,14-15,17-18,23-24,26-27H,1-2,5-6,8-10H2,(H,21,25)/t14-,15+,17-,18-/m1/s1 PACMVUIFERIFEK-CYGHRXIMSA-N 50438751 CHEMBL2414883 Lysosomal acid glucosylceramidase Homo sapiens 3200 ChEMBL 10.1016/j.bmc.2013.06.054 10.7270/Q2XG9SJX 23880081 Cheng, WC; Weng, CY; Yun, WY; Chang, SY; Lin, YC; Tsai, FJ; Huang, FY; Chen, YR Genomics Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50438751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50438751&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 71770662 175451068 CHEMBL2414883 ZINC96282608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51073115 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1 InChI=1S/C31H38N2O5/c34-22-26-29(37)30(38)27(35)21-33(26)19-11-10-18-32-28(36)20-31(23-12-4-1-5-13-23,24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-9,12-17,26-27,29-30,34-35,37-38H,10-11,18-22H2,(H,32,36)/t26-,27+,29-,30-/m1/s1 QDXHUVWMIIQUEJ-RGTFROLJSA-N 50438752 CHEMBL2414882 Lysosomal acid glucosylceramidase Homo sapiens 400 ChEMBL 10.1016/j.bmc.2013.06.054 10.7270/Q2XG9SJX 23880081 Cheng, WC; Weng, CY; Yun, WY; Chang, SY; Lin, YC; Tsai, FJ; Huang, FY; Chen, YR Genomics Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50438752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50438752&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 71770661 175451069 CHEMBL2414882 ZINC96282609 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51073116 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCNC(=O)C1CCc2ccccc2C1 InChI=1S/C21H32N2O5/c24-13-17-19(26)20(27)18(25)12-23(17)10-4-3-9-22-21(28)16-8-7-14-5-1-2-6-15(14)11-16/h1-2,5-6,16-20,24-27H,3-4,7-13H2,(H,22,28)/t16?,17-,18+,19-,20-/m1/s1 SYQRNTJYAAQKGH-DGDSNLKDSA-N 50438753 CHEMBL2414881 Lysosomal acid glucosylceramidase Homo sapiens 1000 ChEMBL 10.1016/j.bmc.2013.06.054 10.7270/Q2XG9SJX 23880081 Cheng, WC; Weng, CY; Yun, WY; Chang, SY; Lin, YC; Tsai, FJ; Huang, FY; Chen, YR Genomics Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50438753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50438753&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 71770660 175451070 CHEMBL2414881 ZINC96282611 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51073117 OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCNC(=O)CC1c2ccccc2-c2ccccc12 InChI=1S/C25H32N2O5/c28-15-21-24(31)25(32)22(29)14-27(21)12-6-5-11-26-23(30)13-20-18-9-3-1-7-16(18)17-8-2-4-10-19(17)20/h1-4,7-10,20-22,24-25,28-29,31-32H,5-6,11-15H2,(H,26,30)/t21-,22+,24-,25-/m1/s1 SSALNGJMPHAYKJ-PEISPCAHSA-N 50438754 CHEMBL2414880 Lysosomal acid glucosylceramidase Homo sapiens 400 ChEMBL 10.1016/j.bmc.2013.06.054 10.7270/Q2XG9SJX 23880081 Cheng, WC; Weng, CY; Yun, WY; Chang, SY; Lin, YC; Tsai, FJ; Huang, FY; Chen, YR Genomics Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50438754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50438754&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 71770659 175451071 CHEMBL2414880 ZINC96282612 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50181200 OC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6+/m1/s1 PFYHYHZGDNWFIF-KAZBKCHUSA-N 50241865 2,5-dideoxy-2,5-imino-D-altritol::2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine::CHEMBL469844 Lysosomal acid glucosylceramidase Homo sapiens 200 ChEMBL 10.1016/s0960-894x(01)00209-8 10.7270/Q2JQ1097 11392550 Hermetter, A; Scholze, H; Stutz, AE; Withers, SG; Wrodnigg, TM Institut für Biochemie der Technischen Universität Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241865&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10261406 104098882 CHEMBL469844 ZINC05766623 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50181201 NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O InChI=1S/C6H14N2O3/c7-1-3-5(10)6(11)4(2-9)8-3/h3-6,8-11H,1-2,7H2/t3-,4-,5?,6+/m1/s1 NJOZFAFEQVQFJI-CERMHHMHSA-N 50099009 (3S,4S,5R)-2-Aminomethyl-5-hydroxymethyl-pyrrolidine-3,4-diol::BDBM50204612::CHEMBL3350086 Lysosomal acid glucosylceramidase Homo sapiens 25 ChEMBL 10.1016/s0960-894x(01)00209-8 10.7270/Q2JQ1097 11392550 Hermetter, A; Scholze, H; Stutz, AE; Withers, SG; Wrodnigg, TM Institut für Biochemie der Technischen Universität Graz http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099009&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 12103488 103995940 CHEMBL9745CHEMBL3350086 ZINC26003639 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50577692 OC[C@@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5+,6+/m0/s1 QPYJXFZUIJOGNX-KVQBGUIXSA-N 50350757 CHEMBL1818432 Lysosomal acid glucosylceramidase Homo sapiens 110 ChEMBL 10.1016/s0960-894x(99)00042-6 10.7270/Q2V40VQH 10098675 Schuster, M Technische Universit£t Berlin http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350757&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10820691 136357443 CHEMBL1818432 ZINC06361564 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003209 OCC1C(O)C(O)C2OC(Nc3ccccc3)=NC12 InChI=1S/C13H16N2O4/c16-6-8-9-12(11(18)10(8)17)19-13(15-9)14-7-4-2-1-3-5-7/h1-5,8-12,16-18H,6H2,(H,14,15) HVHMVEURTGZSLQ-UHFFFAOYSA-N 50283603 4-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-5,6-diol::CHEMBL313375 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283603&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44322890 104125260 CHEMBL313375 ZINC40688978 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003216 OCC1(O)C(O)C(O)C2N=C(Nc3ccccc3)OC12 InChI=1S/C13H16N2O5/c16-6-13(19)10(18)9(17)8-11(13)20-12(15-8)14-7-4-2-1-3-5-7/h1-5,8-11,16-19H,6H2,(H,14,15) WWMAKEJMUWTUCR-UHFFFAOYSA-N 50283604 6-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol::CHEMBL88408 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283604&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44322630 104125261 CHEMBL88408 ZINC40457102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003217 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 LXBIFEVIBLOUGU-JGWLITMVSA-N 18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US9181184, 1::dNM Lysosomal acid glucosylceramidase Homo sapiens 118000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DNJ 1DIE,1DOG,1I75,1OIM,2J77,2JKE,2PWD,3GBE,3GXT 29435 46518429 44369 CHEMBL307429 4642 C16843 ZINC03794714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003218 OCC12OC(Nc3ccccc3)=NC1C(O)C(O)C2O InChI=1S/C13H16N2O5/c16-6-13-10(8(17)9(18)11(13)19)15-12(20-13)14-7-4-2-1-3-5-7/h1-5,8-11,16-19H,6H2,(H,14,15) PSFQMRKUJZUIRS-UHFFFAOYSA-N 50283602 6a-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol::CHEMBL86772 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283602&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 21479008 104125259 CHEMBL86772 ZINC36323414 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003219 OCC12OC(Nc3ccccc3)=NC1C(O)C(O)C2O InChI=1S/C13H16N2O5/c16-6-13-10(8(17)9(18)11(13)19)15-12(20-13)14-7-4-2-1-3-5-7/h1-5,8-11,16-19H,6H2,(H,14,15) PSFQMRKUJZUIRS-UHFFFAOYSA-N 50283602 6a-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol::CHEMBL86772 Lysosomal acid glucosylceramidase Homo sapiens 4890 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283602&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 21479008 104125259 CHEMBL86772 ZINC36323414 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003223 OCC12OC(Nc3ccccc3)=NC1C(O)C(O)C2O InChI=1S/C13H16N2O5/c16-6-13-10(8(17)9(18)11(13)19)15-12(20-13)14-7-4-2-1-3-5-7/h1-5,8-11,16-19H,6H2,(H,14,15) PSFQMRKUJZUIRS-UHFFFAOYSA-N 50283602 6a-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol::CHEMBL86772 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283602&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 21479008 104125259 CHEMBL86772 ZINC36323414 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50003230 NC1C(O)C(O)C(O)C1O InChI=1S/C5H11NO4/c6-1-2(7)4(9)5(10)3(1)8/h1-5,7-10H,6H2 LZCRRHQKPAEPKL-UHFFFAOYSA-N 50283600 5-Amino-cyclopentane-1,2,3,4-tetraol::CHEMBL87120 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283600&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search AOL 2F7Q 13880378 104125257 CHEMBL87120 ZINC34173977 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50561506 NC1C(O)C(O)C(O)C1O InChI=1S/C5H11NO4/c6-1-2(7)4(9)5(10)3(1)8/h1-5,7-10H,6H2 LZCRRHQKPAEPKL-UHFFFAOYSA-N 50283600 5-Amino-cyclopentane-1,2,3,4-tetraol::CHEMBL87120 Lysosomal acid glucosylceramidase Homo sapiens 7780 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283600&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search AOL 2F7Q 13880378 104125257 CHEMBL87120 ZINC34173977 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50561579 NC1C(O)C(O)C(O)C1(O)CO InChI=1S/C6H13NO5/c7-4-2(9)3(10)5(11)6(4,12)1-8/h2-5,8-12H,1,7H2 FFHSAAAKCQFNFB-UHFFFAOYSA-N 50283598 5-Amino-1-hydroxymethyl-cyclopentane-1,2,3,4-tetraol::CHEMBL88413 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283598&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9815399 104125255 CHEMBL88413 ZINC40457127 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50561595 NC1C(O)C(O)C(O)C1(O)CO InChI=1S/C6H13NO5/c7-4-2(9)3(10)5(11)6(4,12)1-8/h2-5,8-12H,1,7H2 FFHSAAAKCQFNFB-UHFFFAOYSA-N 50283598 5-Amino-1-hydroxymethyl-cyclopentane-1,2,3,4-tetraol::CHEMBL88413 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283598&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9815399 104125255 CHEMBL88413 ZINC40457127 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50561599 NC1C(O)C(O)C(O)C1O InChI=1S/C5H11NO4/c6-1-2(7)4(9)5(10)3(1)8/h1-5,7-10H,6H2 LZCRRHQKPAEPKL-UHFFFAOYSA-N 50283600 5-Amino-cyclopentane-1,2,3,4-tetraol::CHEMBL87120 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283600&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search AOL 2F7Q 13880378 104125257 CHEMBL87120 ZINC34173977 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50561600 NC1C(O)C(O)C(O)C1O InChI=1S/C5H11NO4/c6-1-2(7)4(9)5(10)3(1)8/h1-5,7-10H,6H2 LZCRRHQKPAEPKL-UHFFFAOYSA-N 50283600 5-Amino-cyclopentane-1,2,3,4-tetraol::CHEMBL87120 Lysosomal acid glucosylceramidase Homo sapiens 83800 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283600&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search AOL 2F7Q 13880378 104125257 CHEMBL87120 ZINC34173977 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50561603 NC1C(O)C(O)C(O)C1O InChI=1S/C5H11NO4/c6-1-2(7)4(9)5(10)3(1)8/h1-5,7-10H,6H2 LZCRRHQKPAEPKL-UHFFFAOYSA-N 50283600 5-Amino-cyclopentane-1,2,3,4-tetraol::CHEMBL87120 Lysosomal acid glucosylceramidase Homo sapiens 83800 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283600&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search AOL 2F7Q 13880378 104125257 CHEMBL87120 ZINC34173977 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50561604 OC1C(O)C2OC(Nc3ccccc3)=NC2C1O InChI=1S/C12H14N2O4/c15-8-7-11(10(17)9(8)16)18-12(14-7)13-6-4-2-1-3-5-6/h1-5,7-11,15-17H,(H,13,14) KKMTTWOORXFHAR-UHFFFAOYSA-N 50283601 2-Phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol::CHEMBL86865 Lysosomal acid glucosylceramidase Homo sapiens 2160 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283601&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44322665 104125258 CHEMBL86865 ZINC36323399 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50561611 OC1C(O)C2OC(Nc3ccccc3)=NC2C1O InChI=1S/C12H14N2O4/c15-8-7-11(10(17)9(8)16)18-12(14-7)13-6-4-2-1-3-5-6/h1-5,7-11,15-17H,(H,13,14) KKMTTWOORXFHAR-UHFFFAOYSA-N 50283601 2-Phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol::CHEMBL86865 Lysosomal acid glucosylceramidase Homo sapiens 6390 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283601&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44322665 104125258 CHEMBL86865 ZINC36323399 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50561654 OC1C(O)C2OC(Nc3ccccc3)=NC2C1O InChI=1S/C12H14N2O4/c15-8-7-11(10(17)9(8)16)18-12(14-7)13-6-4-2-1-3-5-6/h1-5,7-11,15-17H,(H,13,14) KKMTTWOORXFHAR-UHFFFAOYSA-N 50283601 2-Phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol::CHEMBL86865 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283601&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44322665 104125258 CHEMBL86865 ZINC36323399 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50561655 OC1C(O)C2OC(Nc3ccccc3)=NC2C1O InChI=1S/C12H14N2O4/c15-8-7-11(10(17)9(8)16)18-12(14-7)13-6-4-2-1-3-5-6/h1-5,7-11,15-17H,(H,13,14) KKMTTWOORXFHAR-UHFFFAOYSA-N 50283601 2-Phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol::CHEMBL86865 Lysosomal acid glucosylceramidase Homo sapiens 200 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283601&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44322665 104125258 CHEMBL86865 ZINC36323399 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50561657 OC1C(O)C2OC(Nc3ccccc3)=NC2C1O InChI=1S/C12H14N2O4/c15-8-7-11(10(17)9(8)16)18-12(14-7)13-6-4-2-1-3-5-6/h1-5,7-11,15-17H,(H,13,14) KKMTTWOORXFHAR-UHFFFAOYSA-N 50283601 2-Phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol::CHEMBL86865 Lysosomal acid glucosylceramidase Homo sapiens 200 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283601&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44322665 104125258 CHEMBL86865 ZINC36323399 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50561718 OCC1(O)C(O)C(O)C2(CO)OCC(Nc3ccccc3)=NC12 InChI=1S/C15H20N2O6/c18-7-14(22)11(20)12(21)15(8-19)13(14)17-10(6-23-15)16-9-4-2-1-3-5-9/h1-5,11-13,18-22H,6-8H2,(H,16,17) VCQTVMUCIZQHEV-UHFFFAOYSA-N 50283599 5,7a-Bis-hydroxymethyl-3-phenylamino-2,4a,5,6,7,7a-hexahydro-cyclopenta[1,4]oxazine-5,6,7-triol::CHEMBL314403 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1016/S0960-894X(01)80688-0 10.7270/Q21V5FFN Uchida, C; Kimura, H; Ogawa, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283599&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 44322883 104125256 CHEMBL314403 ZINC40689069 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544570 O[C@@H]1CNC2(CC2)[C@H](\C=C\F)[C@H]1O InChI=1S/C9H14FNO2/c10-4-1-6-8(13)7(12)5-11-9(6)2-3-9/h1,4,6-8,11-13H,2-3,5H2/b4-1+/t6-,7-,8-/m1/s1 OMLFGBKTKHVSQF-HIDXBHDTSA-N 285836 (6R,7R,8S)-8-((E)-2-fluorovinyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 18::US9796680, Example 18 Lysosomal acid glucosylceramidase Homo sapiens 20.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285836&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197668 378169473 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544571 O[C@@H]1CNC2(CC2)[C@H](C=C(F)F)[C@H]1O InChI=1S/C9H13F2NO2/c10-7(11)3-5-8(14)6(13)4-12-9(5)1-2-9/h3,5-6,8,12-14H,1-2,4H2/t5-,6-,8-/m1/s1 GYYKXPIHCCASMM-ATRFCDNQSA-N 285837 (6R,7R,8S)-8-(2,2-difluorovinyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 19::US9796680, Example 19 Lysosomal acid glucosylceramidase Homo sapiens 75.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285837&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197628 378169474 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544572 O[C@@H]1CNC2(CC2)[C@H](C#C)[C@H]1O InChI=1S/C9H13NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h1,6-8,10-12H,3-5H2/t6-,7-,8-/m1/s1 WZAZBGHAPRDLFW-BWZBUEFSSA-N 285838 (6R,7R,8S)-8-ethynyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 20::US9796680, Example 20 Lysosomal acid glucosylceramidase Homo sapiens 13.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285838&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197640 378169475 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544573 O[C@@H]1CNC2(CC2)[C@H](C#C)[C@H]1O InChI=1S/C9H13NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h1,6-8,10-12H,3-5H2/t6-,7-,8-/m1/s1 WZAZBGHAPRDLFW-BWZBUEFSSA-N 285838 (6R,7R,8S)-8-ethynyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 20::US9796680, Example 20 Lysosomal acid glucosylceramidase Homo sapiens 7.90 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285838&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197640 378169475 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544574 CC#C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C10H15NO2/c1-2-3-7-9(13)8(12)6-11-10(7)4-5-10/h7-9,11-13H,4-6H2,1H3/t7-,8-,9-/m1/s1 CFLYIQUIFBLZQN-IWSPIJDZSA-N 285839 (6R,7R,8S)-8-(prop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 21::US9796680, Example 21 Lysosomal acid glucosylceramidase Homo sapiens 9.70 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285839&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197611 378169476 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544575 CC#C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C10H15NO2/c1-2-3-7-9(13)8(12)6-11-10(7)4-5-10/h7-9,11-13H,4-6H2,1H3/t7-,8-,9-/m1/s1 CFLYIQUIFBLZQN-IWSPIJDZSA-N 285839 (6R,7R,8S)-8-(prop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 21::US9796680, Example 21 Lysosomal acid glucosylceramidase Homo sapiens 6.70 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285839&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197611 378169476 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544576 CCC#C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C11H17NO2/c1-2-3-4-8-10(14)9(13)7-12-11(8)5-6-11/h8-10,12-14H,2,5-7H2,1H3/t8-,9-,10-/m1/s1 RUUGSGCVICOVQG-OPRDCNLKSA-N 285840 (6R,7R,8S)-8-(but-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 22::US9796680, Example 22 Lysosomal acid glucosylceramidase Homo sapiens 2.40 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285840&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118199409 378169477 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544577 CCCC#C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C12H19NO2/c1-2-3-4-5-9-11(15)10(14)8-13-12(9)6-7-12/h9-11,13-15H,2-3,6-8H2,1H3/t9-,10-,11-/m1/s1 USECWGHCBFNPNA-GMTAPVOTSA-N 285841 (6R,7R,8S)-8-(pent-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 23::US9796680, Example 23 Lysosomal acid glucosylceramidase Homo sapiens 6.70 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285841&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197648 378169478 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544578 OCC#C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C10H15NO3/c12-5-1-2-7-9(14)8(13)6-11-10(7)3-4-10/h7-9,11-14H,3-6H2/t7-,8-,9-/m1/s1 JGTGAWSDCHTBRU-IWSPIJDZSA-N 285842 (6R,7R,8S)-8-(3-hydroxyprop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 24::US9796680, Example 24 Lysosomal acid glucosylceramidase Homo sapiens 17.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285842&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197658 378169479 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544579 O[C@@H]1CNC2(CC2)[C@H](C#CCF)[C@H]1O InChI=1S/C10H14FNO2/c11-5-1-2-7-9(14)8(13)6-12-10(7)3-4-10/h7-9,12-14H,3-6H2/t7-,8-,9-/m1/s1 VGBGTBVAHJMEJG-IWSPIJDZSA-N 285843 (6R,7R,8S)-8-(3-fluoroprop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 25::US9796680, Example 25 Lysosomal acid glucosylceramidase Homo sapiens 16.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285843&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197625 378169480 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544580 O[C@@H]1CNC2(CC2)[C@H](C#CCF)[C@H]1O InChI=1S/C10H14FNO2/c11-5-1-2-7-9(14)8(13)6-12-10(7)3-4-10/h7-9,12-14H,3-6H2/t7-,8-,9-/m1/s1 VGBGTBVAHJMEJG-IWSPIJDZSA-N 285843 (6R,7R,8S)-8-(3-fluoroprop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 25::US9796680, Example 25 Lysosomal acid glucosylceramidase Homo sapiens 15.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285843&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197625 378169480 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544581 O[C@@H]1CNC2(CC2)[C@H](C#CC(F)F)[C@H]1O InChI=1S/C10H13F2NO2/c11-8(12)2-1-6-9(15)7(14)5-13-10(6)3-4-10/h6-9,13-15H,3-5H2/t6-,7-,9-/m1/s1 ZTOJJKUWDSLXKW-ZXFLCMHBSA-N 285844 (6R,7R,8S)-8-(3,3-difluoroprop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 26::US9796680, Example 26 Lysosomal acid glucosylceramidase Homo sapiens 22.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285844&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197603 378169481 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544582 O[C@@H]1CNC2(CC2)[C@H](C#CC(F)F)[C@H]1O InChI=1S/C10H13F2NO2/c11-8(12)2-1-6-9(15)7(14)5-13-10(6)3-4-10/h6-9,13-15H,3-5H2/t6-,7-,9-/m1/s1 ZTOJJKUWDSLXKW-ZXFLCMHBSA-N 285844 (6R,7R,8S)-8-(3,3-difluoroprop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 26::US9796680, Example 26 Lysosomal acid glucosylceramidase Homo sapiens 17.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285844&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197603 378169481 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544583 O[C@@H]1CNC2(CC2)[C@H](C#CCCF)[C@H]1O InChI=1S/C11H16FNO2/c12-6-2-1-3-8-10(15)9(14)7-13-11(8)4-5-11/h8-10,13-15H,2,4-7H2/t8-,9-,10-/m1/s1 XHIYEWJIECDGPW-OPRDCNLKSA-N 285845 (6R,7R,8S)-8-(4-fluorobut-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 27::US9796680, Example 27 Lysosomal acid glucosylceramidase Homo sapiens 2.50 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285845&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118199314 378169482 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 544584 O[C@@H]1CNC2(CC2)[C@H](C#CCC(F)F)[C@H]1O InChI=1S/C11H15F2NO2/c12-9(13)3-1-2-7-10(16)8(15)6-14-11(7)4-5-11/h7-10,14-16H,3-6H2/t7-,8-,10-/m1/s1 NCVMRSPXAUZSMD-NQMVMOMDSA-N 285846 (6R,7R,8S)-8-(4,4-difluorobut-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 28::US9796680, Example 28 Lysosomal acid glucosylceramidase Homo sapiens 11.0 7 US Patent 10.7270/Q2S184JZ aid1795701 US10081601 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285846&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118199315 378169483 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605151 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-7-16-13-18(12-15(16)6-1)24-22-19-9-3-4-10-20(19)25-21(26-22)17-8-5-11-23-14-17/h1-11,14,18H,12-13H2,(H,24,25,26) XXCCBJLQMRHXKM-UHFFFAOYSA-N 50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c Lysosomal acid glucosylceramidase Homo sapiens 7.00 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168025 375977485 CHEMBL3923120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605152 CN(C1Cc2ccccc2C1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-27(19-13-16-7-2-3-8-17(16)14-19)23-20-10-4-5-11-21(20)25-22(26-23)18-9-6-12-24-15-18/h2-12,15,19H,13-14H2,1H3 PNUTXYDXSZENHX-UHFFFAOYSA-N 313224 US10167270, Example 2 Lysosomal acid glucosylceramidase Homo sapiens 2150 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313224&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168024 383540134 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605153 CN(CC1COc2ccccc2O1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4O2/c1-27(14-17-15-28-20-10-4-5-11-21(20)29-17)23-18-8-2-3-9-19(18)25-22(26-23)16-7-6-12-24-13-16/h2-13,17H,14-15H2,1H3 JFOVNJQCUHRYOI-UHFFFAOYSA-N 42310 2,3-dihydro-1,4-benzodioxin-3-ylmethyl-methyl-[2-(3-pyridyl)quinazolin-4-yl]amine::MLS000058502::N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-N-methyl-2-(3-pyridinyl)-4-quinazolinamine::N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-N-methyl-2-pyridin-3-yl-quinazolin-4-amine::N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-N-methyl-2-pyridin-3-ylquinazolin-4-amine::SMR000068089::US10167270, Example 3::cid_2999577 Lysosomal acid glucosylceramidase Homo sapiens 1780 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42310&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2999577 252623014 ZINC03408467 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605154 CN(Cc1ccccn1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H17N5/c1-25(14-16-8-4-5-12-22-16)20-17-9-2-3-10-18(17)23-19(24-20)15-7-6-11-21-13-15/h2-13H,14H2,1H3 OMHAHIVIVUSRTR-UHFFFAOYSA-N 313226 US10167270, Example 5 Lysosomal acid glucosylceramidase Homo sapiens 35480 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313226&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168410 383540136 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605155 CN(CC1COCCO1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C19H20N4O2/c1-23(12-15-13-24-9-10-25-15)19-16-6-2-3-7-17(16)21-18(22-19)14-5-4-8-20-11-14/h2-8,11,15H,9-10,12-13H2,1H3 GZDOILBJWUWGMX-UHFFFAOYSA-N 313227 US10167270, Example 6 Lysosomal acid glucosylceramidase Homo sapiens 11220 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313227&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168079 383540137 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605156 CN(Cc1cccnc1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H17N5/c1-25(14-15-6-4-10-21-12-15)20-17-8-2-3-9-18(17)23-19(24-20)16-7-5-11-22-13-16/h2-13H,14H2,1H3 HMIZYQLIFGQLPZ-UHFFFAOYSA-N 313228 US10167270, Example 7 Lysosomal acid glucosylceramidase Homo sapiens 12590 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313228&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168340 383540138 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605157 CN(Cc1ccncc1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H17N5/c1-25(14-15-8-11-21-12-9-15)20-17-6-2-3-7-18(17)23-19(24-20)16-5-4-10-22-13-16/h2-13H,14H2,1H3 VOCGUUQUHZQSBY-UHFFFAOYSA-N 313229 US10167270, Example 8 Lysosomal acid glucosylceramidase Homo sapiens 15850 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313229&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 37144315 383540139 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605158 CN(Cc1cnccn1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C19H16N6/c1-25(13-15-12-21-9-10-22-15)19-16-6-2-3-7-17(16)23-18(24-19)14-5-4-8-20-11-14/h2-12H,13H2,1H3 XVSUAPISUNJYAQ-UHFFFAOYSA-N 313230 US10167270, Example 9 Lysosomal acid glucosylceramidase Homo sapiens 14130 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313230&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168182 383540140 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605159 CN(Cc1cnc2ccccc2n1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H18N6/c1-29(15-17-14-25-20-10-4-5-11-21(20)26-17)23-18-8-2-3-9-19(18)27-22(28-23)16-7-6-12-24-13-16/h2-14H,15H2,1H3 OOEISRKKKNEDPE-UHFFFAOYSA-N 313231 US10167270, Example 10 Lysosomal acid glucosylceramidase Homo sapiens 890 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313231&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168411 383540141 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605160 CN(Cc1ccc2OCOc2c1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4O2/c1-26(13-15-8-9-19-20(11-15)28-14-27-19)22-17-6-2-3-7-18(17)24-21(25-22)16-5-4-10-23-12-16/h2-12H,13-14H2,1H3 KDTNSRXPGJKLNO-UHFFFAOYSA-N 313233 US10167270, Example 11 Lysosomal acid glucosylceramidase Homo sapiens 1000 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313233&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9396951 383540143 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605161 CN(Cc1ccc2CN(C)Cc2c1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C24H23N5/c1-28-15-19-10-9-17(12-20(19)16-28)14-29(2)24-21-7-3-4-8-22(21)26-23(27-24)18-6-5-11-25-13-18/h3-13H,14-16H2,1-2H3 ONRHOYFBYTXYIK-UHFFFAOYSA-N 313234 US10167270, Example 13 Lysosomal acid glucosylceramidase Homo sapiens 44670 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313234&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168183 383540144 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605162 CN(Cc1nc2ccccc2s1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H17N5S/c1-27(14-20-24-18-10-4-5-11-19(18)28-20)22-16-8-2-3-9-17(16)25-21(26-22)15-7-6-12-23-13-15/h2-13H,14H2,1H3 BSBIGOHUKILDHL-UHFFFAOYSA-N 313235 US10167270, Example 14 Lysosomal acid glucosylceramidase Homo sapiens 1120 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313235&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 8568031 383540145 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605163 CN(Cc1nc2ccccc2[nH]1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N6/c1-28(14-20-24-18-10-4-5-11-19(18)25-20)22-16-8-2-3-9-17(16)26-21(27-22)15-7-6-12-23-13-15/h2-13H,14H2,1H3,(H,24,25) YVYRTECTGBSHBB-UHFFFAOYSA-N 313236 US10167270, Example 15 Lysosomal acid glucosylceramidase Homo sapiens 8910 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313236&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168184 383540146 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605164 COc1ccccc1CN(C)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H20N4O/c1-26(15-17-8-3-6-12-20(17)27-2)22-18-10-4-5-11-19(18)24-21(25-22)16-9-7-13-23-14-16/h3-14H,15H2,1-2H3 LREIQWAKRVPUAT-UHFFFAOYSA-N 313237 US10167270, Example 16 Lysosomal acid glucosylceramidase Homo sapiens 3130 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313237&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17408248 383540147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605165 CN(Cc1ccc2ccccc2c1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C25H20N4/c1-29(17-18-12-13-19-7-2-3-8-20(19)15-18)25-22-10-4-5-11-23(22)27-24(28-25)21-9-6-14-26-16-21/h2-16H,17H2,1H3 CCDXJPISMIUJCN-UHFFFAOYSA-N 313238 US10167270, Example 17 Lysosomal acid glucosylceramidase Homo sapiens 1560 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313238&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168021 383540148 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605166 CN(Cc1nc2ccccc2o1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H17N5O/c1-27(14-20-24-18-10-4-5-11-19(18)28-20)22-16-8-2-3-9-17(16)25-21(26-22)15-7-6-12-23-13-15/h2-13H,14H2,1H3 MDEHKLPLPNRLJY-UHFFFAOYSA-N 313239 US10167270, Example 18 Lysosomal acid glucosylceramidase Homo sapiens 11220 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313239&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168191 383540149 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605167 CN(Cc1ccc2OCCOc2c1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4O2/c1-27(15-16-8-9-20-21(13-16)29-12-11-28-20)23-18-6-2-3-7-19(18)25-22(26-23)17-5-4-10-24-14-17/h2-10,13-14H,11-12,15H2,1H3 QONSZJAECYJUQF-UHFFFAOYSA-N 313240 US10167270, Example 19 Lysosomal acid glucosylceramidase Homo sapiens 3980 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313240&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9196028 383540150 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605168 C(Nc1nc(nc2ccccc12)-c1cccnc1)C1COc2ccccc2O1 InChI=1S/C22H18N4O2/c1-2-8-18-17(7-1)22(26-21(25-18)15-6-5-11-23-12-15)24-13-16-14-27-19-9-3-4-10-20(19)28-16/h1-12,16H,13-14H2,(H,24,25,26) SRXDECZUCNOBAY-UHFFFAOYSA-N 313241 US10167270, Example 20 Lysosomal acid glucosylceramidase Homo sapiens 7940 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313241&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4885144 383540151 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605169 CN(Cc1ccc2nsnc2c1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H16N6S/c1-27(13-14-8-9-18-19(11-14)26-28-25-18)21-16-6-2-3-7-17(16)23-20(24-21)15-5-4-10-22-12-15/h2-12H,13H2,1H3 JCJKHVGXFPLXMA-UHFFFAOYSA-N 313242 US10167270, Example 21 Lysosomal acid glucosylceramidase Homo sapiens 3550 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313242&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168023 383540152 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605170 CC(C)(C)OC(=O)N1CCN(CC1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H25N5O2/c1-22(2,3)29-21(28)27-13-11-26(12-14-27)20-17-8-4-5-9-18(17)24-19(25-20)16-7-6-10-23-15-16/h4-10,15H,11-14H2,1-3H3 AUYJJTIWNWXPHS-UHFFFAOYSA-N 313243 US10167270, Example 22 Lysosomal acid glucosylceramidase Homo sapiens 10000 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313243&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168085 383540153 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605171 C1CN(CCN1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C17H17N5/c1-2-6-15-14(5-1)17(22-10-8-18-9-11-22)21-16(20-15)13-4-3-7-19-12-13/h1-7,12,18H,8-11H2 IYEYCSIHXGNRIO-UHFFFAOYSA-N 313244 US10167270, Example 23 Lysosomal acid glucosylceramidase Homo sapiens 35480 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313244&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 3234723 383540154 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605172 CN(Cc1scc2OCCOc12)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H18N4O2S/c1-25(12-18-19-17(13-28-18)26-9-10-27-19)21-15-6-2-3-7-16(15)23-20(24-21)14-5-4-8-22-11-14/h2-8,11,13H,9-10,12H2,1H3 KORYZSGKXGRBRH-UHFFFAOYSA-N 313245 US10167270, Example 24 Lysosomal acid glucosylceramidase Homo sapiens 2000 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313245&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168027 383540155 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605173 CC(C)Cc1noc(CN(C)c2nc(nc3ccccc23)-c2cccnc2)n1 InChI=1S/C21H22N6O/c1-14(2)11-18-24-19(28-26-18)13-27(3)21-16-8-4-5-9-17(16)23-20(25-21)15-7-6-10-22-12-15/h4-10,12,14H,11,13H2,1-3H3 IETPLARAWAUZDU-UHFFFAOYSA-N 313246 US10167270, Example 25 Lysosomal acid glucosylceramidase Homo sapiens 35480 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313246&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168341 383540156 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605174 Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C24H23N5O2S/c1-18-8-10-20(11-9-18)32(30,31)29-15-13-28(14-16-29)24-21-6-2-3-7-22(21)26-23(27-24)19-5-4-12-25-17-19/h2-12,17H,13-16H2,1H3 VAZORWJPDVEPEX-UHFFFAOYSA-N 313247 US10167270, Example 26 Lysosomal acid glucosylceramidase Homo sapiens 1000 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313247&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 25708371 383540157 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605175 C(CC1COc2ccccc2O1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4O2/c1-2-8-19-18(7-1)23(27-22(26-19)16-6-5-12-24-14-16)25-13-11-17-15-28-20-9-3-4-10-21(20)29-17/h1-10,12,14,17H,11,13,15H2,(H,25,26,27) SSKWCWIAZWNMAU-UHFFFAOYSA-N 313248 US10167270, Example 27 Lysosomal acid glucosylceramidase Homo sapiens 600 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313248&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168412 383540158 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605176 CCN(CC1COc2ccccc2O1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C24H22N4O2/c1-2-28(15-18-16-29-21-11-5-6-12-22(21)30-18)24-19-9-3-4-10-20(19)26-23(27-24)17-8-7-13-25-14-17/h3-14,18H,2,15-16H2,1H3 DLQYMIUZWZBNHJ-UHFFFAOYSA-N 313249 US10167270, Example 28 Lysosomal acid glucosylceramidase Homo sapiens 2820 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313249&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168413 383540159 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605177 O=C(C1COc2ccccc2O1)N1CCN(CC1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C26H23N5O3/c32-26(23-17-33-21-9-3-4-10-22(21)34-23)31-14-12-30(13-15-31)25-19-7-1-2-8-20(19)28-24(29-25)18-6-5-11-27-16-18/h1-11,16,23H,12-15,17H2 ZUVVOHAUIMIUIT-UHFFFAOYSA-N 313250 US10167270, Example 29 Lysosomal acid glucosylceramidase Homo sapiens 2240 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313250&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 42909455 383540160 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605178 C(C1COc2ccccc2O1)N1CCN(CC1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C26H25N5O2/c1-2-8-22-21(7-1)26(29-25(28-22)19-6-5-11-27-16-19)31-14-12-30(13-15-31)17-20-18-32-23-9-3-4-10-24(23)33-20/h1-11,16,20H,12-15,17-18H2 IFGVDVFEPYKEEG-UHFFFAOYSA-N 313251 US10167270, Example 30 Lysosomal acid glucosylceramidase Homo sapiens 3130 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313251&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168414 383540161 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605179 CN(Cc1ccc(cc1)-n1ccnc1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C24H20N6/c1-29(16-18-8-10-20(11-9-18)30-14-13-26-17-30)24-21-6-2-3-7-22(21)27-23(28-24)19-5-4-12-25-15-19/h2-15,17H,16H2,1H3 UOBOCMJAQJEXFK-UHFFFAOYSA-N 313255 US10167270, Example 31 Lysosomal acid glucosylceramidase Homo sapiens 19950 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313255&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168028 383540165 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605180 CN(CCC1COc2ccccc2O1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C24H22N4O2/c1-28(14-12-18-16-29-21-10-4-5-11-22(21)30-18)24-19-8-2-3-9-20(19)26-23(27-24)17-7-6-13-25-15-17/h2-11,13,15,18H,12,14,16H2,1H3 BUWQHUDYYNBCQL-UHFFFAOYSA-N 313256 US10167270, Example 32 Lysosomal acid glucosylceramidase Homo sapiens 3160 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313256&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168194 383540166 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605181 CN1CCN(CC1)c1ccc(CNc2nc(nc3ccccc23)-c2cccnc2)cc1 InChI=1S/C25H26N6/c1-30-13-15-31(16-14-30)21-10-8-19(9-11-21)17-27-25-22-6-2-3-7-23(22)28-24(29-25)20-5-4-12-26-18-20/h2-12,18H,13-17H2,1H3,(H,27,28,29) MHAUCLWSWSMVIQ-UHFFFAOYSA-N 313257 US10167270, Example 36 Lysosomal acid glucosylceramidase Homo sapiens 39810 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313257&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168343 383540167 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605182 C1CCC(C1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C18H18N4/c1-2-8-14(7-1)20-18-15-9-3-4-10-16(15)21-17(22-18)13-6-5-11-19-12-13/h3-6,9-12,14H,1-2,7-8H2,(H,20,21,22) WRPPYAYLCGHEDY-UHFFFAOYSA-N 50196516 CHEMBL3968279::US10167270, Compound 7c Lysosomal acid glucosylceramidase Homo sapiens 790 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196516&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17391397 375977473 CHEMBL3968279 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605183 C1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C19H20N4/c1-2-8-15(9-3-1)21-19-16-10-4-5-11-17(16)22-18(23-19)14-7-6-12-20-13-14/h4-7,10-13,15H,1-3,8-9H2,(H,21,22,23) VTJDAALCLRKSIX-UHFFFAOYSA-N 50196518 CHEMBL3920301::US10167270, Compound 4 Lysosomal acid glucosylceramidase Homo sapiens 177 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196518&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 873720 375977475 CHEMBL3920301 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605184 CC(C)N1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H25N5/c1-15(2)26-12-9-17(10-13-26)23-21-18-7-3-4-8-19(18)24-20(25-21)16-6-5-11-22-14-16/h3-8,11,14-15,17H,9-10,12-13H2,1-2H3,(H,23,24,25) ZAMRXVJIXGJERV-UHFFFAOYSA-N 50196532 CHEMBL3912910::US10167270, Compound 6j Lysosomal acid glucosylceramidase Homo sapiens 35480 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196532&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16355345 375977489 CHEMBL3912910 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605185 C1CC1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C16H14N4/c1-2-6-14-13(5-1)16(18-12-7-8-12)20-15(19-14)11-4-3-9-17-10-11/h1-6,9-10,12H,7-8H2,(H,18,19,20) ZYMFUDCVHZLPBA-UHFFFAOYSA-N 50196529 CHEMBL3979185::US10167270, Compound 7e Lysosomal acid glucosylceramidase Homo sapiens 39810 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196529&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 8080175 375977486 CHEMBL3979185 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605186 C1CC(C1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C17H16N4/c1-2-9-15-14(8-1)17(19-13-6-3-7-13)21-16(20-15)12-5-4-10-18-11-12/h1-2,4-5,8-11,13H,3,6-7H2,(H,19,20,21) WBKIOFACQKHWCN-UHFFFAOYSA-N 50196520 CHEMBL3944808::US10167270, Compound 7d Lysosomal acid glucosylceramidase Homo sapiens 4470 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196520&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168092 375977477 CHEMBL3944808 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605187 C(N1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1)c1ccccc1 InChI=1S/C25H25N5/c1-2-7-19(8-3-1)18-30-15-12-21(13-16-30)27-25-22-10-4-5-11-23(22)28-24(29-25)20-9-6-14-26-17-20/h1-11,14,17,21H,12-13,15-16,18H2,(H,27,28,29) FPSNRFFFQDOELT-UHFFFAOYSA-N 50196625 CHEMBL1405704::US10167270, Compound 6k Lysosomal acid glucosylceramidase Homo sapiens 31620 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196625&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4882879 375977497 CHEMBL1405704 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605188 CCC1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-2-15-9-11-17(12-10-15)23-21-18-7-3-4-8-19(18)24-20(25-21)16-6-5-13-22-14-16/h3-8,13-15,17H,2,9-12H2,1H3,(H,23,24,25) NSUPJZHPKLIZHG-UHFFFAOYSA-N 50196627 CHEMBL3929224::US10167270, Compound 6b Lysosomal acid glucosylceramidase Homo sapiens 126 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196627&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168443 375977499 CHEMBL3929224 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605189 CC1CCCCC1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-14-7-2-4-10-17(14)22-20-16-9-3-5-11-18(16)23-19(24-20)15-8-6-12-21-13-15/h3,5-6,8-9,11-14,17H,2,4,7,10H2,1H3,(H,22,23,24) SGTUPNLPSTUUDW-UHFFFAOYSA-N 313268 US10167270, Example 48 Lysosomal acid glucosylceramidase Homo sapiens 89.0 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313268&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 23989037 383540178 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605190 CC1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-14-8-10-16(11-9-14)22-20-17-6-2-3-7-18(17)23-19(24-20)15-5-4-12-21-13-15/h2-7,12-14,16H,8-11H2,1H3,(H,22,23,24) ZIBKSPGRIZLUEF-UHFFFAOYSA-N 50196535 CHEMBL3948124::US10167270, Compound 6a Lysosomal acid glucosylceramidase Homo sapiens 56.0 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196535&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4965949 375977492 CHEMBL3948124 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605191 C(Nc1nc(nc2ccccc12)-c1cccnc1)c1ccccc1 InChI=1S/C20H16N4/c1-2-7-15(8-3-1)13-22-20-17-10-4-5-11-18(17)23-19(24-20)16-9-6-12-21-14-16/h1-12,14H,13H2,(H,22,23,24) AELMNLIYFALJIR-UHFFFAOYSA-N 50033284 Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine::CHEMBL119841::US10167270, Compound 8b::cid_667555 Lysosomal acid glucosylceramidase Homo sapiens 7080 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033284&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 667555 103941601 CHEMBL119841 ZINC00005903 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605192 C(CNc1nc(nc2ccccc12)-c1cccnc1)Cc1ccccc1 InChI=1S/C22H20N4/c1-2-8-17(9-3-1)10-6-15-24-22-19-12-4-5-13-20(19)25-21(26-22)18-11-7-14-23-16-18/h1-5,7-9,11-14,16H,6,10,15H2,(H,24,25,26) KNPAHIAFSKZRIB-UHFFFAOYSA-N 50196630 CHEMBL3942452::US10167270, Compound 8d Lysosomal acid glucosylceramidase Homo sapiens 1780 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196630&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168417 375977501 CHEMBL3942452 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605193 C(CCc1ccccc1)CNc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H22N4/c1-2-9-18(10-3-1)11-6-7-16-25-23-20-13-4-5-14-21(20)26-22(27-23)19-12-8-15-24-17-19/h1-5,8-10,12-15,17H,6-7,11,16H2,(H,25,26,27) LXPSTEYVBFGHEM-UHFFFAOYSA-N 50196626 CHEMBL3972062::US10167270, Compound 8e Lysosomal acid glucosylceramidase Homo sapiens 1580 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196626&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168418 375977498 CHEMBL3972062 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605194 Fc1cccc(CCNc2nc(nc3ccccc23)-c2cccnc2)c1 InChI=1S/C21H17FN4/c22-17-7-3-5-15(13-17)10-12-24-21-18-8-1-2-9-19(18)25-20(26-21)16-6-4-11-23-14-16/h1-9,11,13-14H,10,12H2,(H,24,25,26) ASWGTFQTTWCZGD-UHFFFAOYSA-N 313277 US10167270, Example 55 Lysosomal acid glucosylceramidase Homo sapiens 141 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313277&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9026536 383540185 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605195 CN(C1CCCCC1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-24(16-9-3-2-4-10-16)20-17-11-5-6-12-18(17)22-19(23-20)15-8-7-13-21-14-15/h5-8,11-14,16H,2-4,9-10H2,1H3 XAEHVHAYPVMIGW-UHFFFAOYSA-N 313278 US10167270, Example 56 Lysosomal acid glucosylceramidase Homo sapiens 5010 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313278&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 7765683 383540186 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605196 C(Nc1nc(nc2ccccc12)-c1cccnc1)C1CCCCC1 InChI=1S/C20H22N4/c1-2-7-15(8-3-1)13-22-20-17-10-4-5-11-18(17)23-19(24-20)16-9-6-12-21-14-16/h4-6,9-12,14-15H,1-3,7-8,13H2,(H,22,23,24) VADSISQHMHUCOP-UHFFFAOYSA-N 50196624 CHEMBL3963682::US10167270, Compound 7h Lysosomal acid glucosylceramidase Homo sapiens 354 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196624&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 21808535 375977496 CHEMBL3963682 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605197 C1CCCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-2-4-10-16(9-3-1)22-20-17-11-5-6-12-18(17)23-19(24-20)15-8-7-13-21-14-15/h5-8,11-14,16H,1-4,9-10H2,(H,22,23,24) REYRWOJVPIEDER-UHFFFAOYSA-N 50196530 CHEMBL3974789::US10167270, Compound 7b Lysosomal acid glucosylceramidase Homo sapiens 63.0 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196530&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2456688 375977487 CHEMBL3974789 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605198 CN(CCc1cccc(F)c1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H19FN4/c1-27(13-11-16-6-4-8-18(23)14-16)22-19-9-2-3-10-20(19)25-21(26-22)17-7-5-12-24-15-17/h2-10,12,14-15H,11,13H2,1H3 SLZYJPKBQBKACT-UHFFFAOYSA-N 313281 US10167270, Example 59 Lysosomal acid glucosylceramidase Homo sapiens 4470 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313281&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168094 383540189 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605199 C(Cc1ccccc1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H18N4/c1-2-7-16(8-3-1)12-14-23-21-18-10-4-5-11-19(18)24-20(25-21)17-9-6-13-22-15-17/h1-11,13,15H,12,14H2,(H,23,24,25) UWQNTLVHUVARDK-UHFFFAOYSA-N 50033286 CHEMBL544818::Phenethyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine; dihydrochloride::US10167270, Compound 8c Lysosomal acid glucosylceramidase Homo sapiens 112 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033286&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 874599 103941603 CHEMBL544818 ZINC00442667 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605200 COC1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4O/c1-25-16-10-8-15(9-11-16)22-20-17-6-2-3-7-18(17)23-19(24-20)14-5-4-12-21-13-14/h2-7,12-13,15-16H,8-11H2,1H3,(H,22,23,24) KHUIQQWXJGLXHU-UHFFFAOYSA-N 50196633 CHEMBL3965871::US10167270, Compound 6d Lysosomal acid glucosylceramidase Homo sapiens 251 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196633&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168347 375977504 CHEMBL3965871 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605201 C1COCC(C1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C18H18N4O/c1-2-8-16-15(7-1)18(20-14-6-4-10-23-12-14)22-17(21-16)13-5-3-9-19-11-13/h1-3,5,7-9,11,14H,4,6,10,12H2,(H,20,21,22) NSTBSEQCWALGQL-UHFFFAOYSA-N 50196632 CHEMBL3921895::US10167270, Compound 6h Lysosomal acid glucosylceramidase Homo sapiens 891 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196632&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168199 375977503 CHEMBL3921895 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605202 C(CC1CCCCC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-2-7-16(8-3-1)12-14-23-21-18-10-4-5-11-19(18)24-20(25-21)17-9-6-13-22-15-17/h4-6,9-11,13,15-16H,1-3,7-8,12,14H2,(H,23,24,25) HDBYPZURDNCVJI-UHFFFAOYSA-N 50196631 CHEMBL3898722::US10167270, Compound 7i Lysosomal acid glucosylceramidase Homo sapiens 282 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196631&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168444 375977502 CHEMBL3898722 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605203 C1CC2CCC1N2c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C19H18N4/c1-2-6-17-16(5-1)19(23-14-7-8-15(23)10-9-14)22-18(21-17)13-4-3-11-20-12-13/h1-6,11-12,14-15H,7-10H2 AGXZWQMVVSVIAZ-UHFFFAOYSA-N 313286 US10167270, Example 64 Lysosomal acid glucosylceramidase Homo sapiens 2240 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313286&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168097 383540194 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605204 FC1(F)CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C19H18F2N4/c20-19(21)9-7-14(8-10-19)23-18-15-5-1-2-6-16(15)24-17(25-18)13-4-3-11-22-12-13/h1-6,11-12,14H,7-10H2,(H,23,24,25) GQSVORBZXSEUJW-UHFFFAOYSA-N 50196517 CHEMBL3980248::US10167270, Compound 6f Lysosomal acid glucosylceramidase Homo sapiens 316 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196517&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168022 375977474 CHEMBL3980248 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605205 C1Cc2ccccc2CC1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27) NNXTWWKGCDOEQE-UHFFFAOYSA-N 313288 US10167270, Example 66 Lysosomal acid glucosylceramidase Homo sapiens 6.00 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313288&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168419 383540196 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605206 C1Cc2ccccc2C1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-8-17-15(6-1)11-12-20(17)25-22-18-9-3-4-10-19(18)24-21(26-22)16-7-5-13-23-14-16/h1-10,13-14,20H,11-12H2,(H,24,25,26) NHFIHEPUGCTNFM-UHFFFAOYSA-N 50196527 CHEMBL3970658::US10167270, Compound 9e Lysosomal acid glucosylceramidase Homo sapiens 891 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196527&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17518657 375977484 CHEMBL3970658 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605207 C1CC(Nc2nc(nc3ccccc23)-c2cccnc2)c2ccccc2C1 InChI=1S/C23H20N4/c1-2-10-18-16(7-1)8-5-13-20(18)26-23-19-11-3-4-12-21(19)25-22(27-23)17-9-6-14-24-15-17/h1-4,6-7,9-12,14-15,20H,5,8,13H2,(H,25,26,27) XGFDEYBZTPSJCH-UHFFFAOYSA-N 50196628 CHEMBL3932095::US10167270, Compound 9d Lysosomal acid glucosylceramidase Homo sapiens 1120 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196628&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168445 375977500 CHEMBL3932095 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605208 C(Cc1ccccn1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H17N5/c1-2-9-18-17(8-1)20(23-13-10-16-7-3-4-12-22-16)25-19(24-18)15-6-5-11-21-14-15/h1-9,11-12,14H,10,13H2,(H,23,24,25) XDSFFKXQUALAPV-UHFFFAOYSA-N 50196515 CHEMBL3913022::US10167270, Compound 8f Lysosomal acid glucosylceramidase Homo sapiens 1120 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196515&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9282942 375977472 CHEMBL3913022 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605209 C(Cc1cccnc1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H17N5/c1-2-8-18-17(7-1)20(23-12-9-15-5-3-10-21-13-15)25-19(24-18)16-6-4-11-22-14-16/h1-8,10-11,13-14H,9,12H2,(H,23,24,25) UKYOLERGWNZMQS-UHFFFAOYSA-N 50196523 CHEMBL3914158::US10167270, Compound 8g Lysosomal acid glucosylceramidase Homo sapiens 5010 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196523&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 31408646 375977480 CHEMBL3914158 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605210 Nc1ccc(CCNc2nc(nc3ccccc23)-c2cccnc2)cc1 InChI=1S/C21H19N5/c22-17-9-7-15(8-10-17)11-13-24-21-18-5-1-2-6-19(18)25-20(26-21)16-4-3-12-23-14-16/h1-10,12,14H,11,13,22H2,(H,24,25,26) XWHSCQOFZKOWDJ-UHFFFAOYSA-N 313293 US10167270, Example 71 Lysosomal acid glucosylceramidase Homo sapiens 2000 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313293&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168193 383540200 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605211 C(Cc1c[nH]c2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H19N5/c1-3-9-20-18(7-1)16(15-26-20)11-13-25-23-19-8-2-4-10-21(19)27-22(28-23)17-6-5-12-24-14-17/h1-10,12,14-15,26H,11,13H2,(H,25,27,28) FZWJFCAIBSMJAE-UHFFFAOYSA-N 313294 US10167270, Example 72 Lysosomal acid glucosylceramidase Homo sapiens 1280 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313294&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9282801 383540201 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605212 Cc1ccc(CCNc2nc(nc3ccccc23)-c2cccnc2)cc1 InChI=1S/C22H20N4/c1-16-8-10-17(11-9-16)12-14-24-22-19-6-2-3-7-20(19)25-21(26-22)18-5-4-13-23-15-18/h2-11,13,15H,12,14H2,1H3,(H,24,25,26) RIOZZGYCEZTEHR-UHFFFAOYSA-N 313295 US10167270, Example 73 Lysosomal acid glucosylceramidase Homo sapiens 1780 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313295&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168349 383540202 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605213 CN(C1CCc2ccccc2C1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C24H22N4/c1-28(20-13-12-17-7-2-3-8-18(17)15-20)24-21-10-4-5-11-22(21)26-23(27-24)19-9-6-14-25-16-19/h2-11,14,16,20H,12-13,15H2,1H3 VQHVGTSGQUJEJG-UHFFFAOYSA-N 313296 US10167270, Example 75 Lysosomal acid glucosylceramidase Homo sapiens 1580 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313296&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168344 383540203 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605214 C1CCCC(CCC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-2-4-10-17(11-5-3-1)23-21-18-12-6-7-13-19(18)24-20(25-21)16-9-8-14-22-15-16/h6-9,12-15,17H,1-5,10-11H2,(H,23,24,25) KPHDEGYZCGJLCL-UHFFFAOYSA-N 50196531 CHEMBL3964444::US10167270, Compound 7a Lysosomal acid glucosylceramidase Homo sapiens 28.0 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196531&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17546054 375977488 CHEMBL3964444 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605215 CC1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-14-8-10-16(11-9-14)22-20-17-6-2-3-7-18(17)23-19(24-20)15-5-4-12-21-13-15/h2-7,12-14,16H,8-11H2,1H3,(H,22,23,24) ZIBKSPGRIZLUEF-UHFFFAOYSA-N 50196535 CHEMBL3948124::US10167270, Compound 6a Lysosomal acid glucosylceramidase Homo sapiens 20.0 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196535&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4965949 375977492 CHEMBL3948124 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605216 C1CC2CC1CC2Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H20N4/c1-2-6-17-16(5-1)20(23-18-11-13-7-8-14(18)10-13)24-19(22-17)15-4-3-9-21-12-15/h1-6,9,12-14,18H,7-8,10-11H2,(H,22,23,24) FPKKVYLMXWIWLV-UHFFFAOYSA-N 50196635 CHEMBL3970989::US10167270, Compound 7g Lysosomal acid glucosylceramidase Homo sapiens 355 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196635&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168197 375977506 CHEMBL3970989 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605217 C1C2CC3CC1CC(C2)(C3)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H24N4/c1-2-6-20-19(5-1)22(26-21(25-20)18-4-3-7-24-14-18)27-23-11-15-8-16(12-23)10-17(9-15)13-23/h1-7,14-17H,8-13H2,(H,25,26,27) LEWAHVWACBZCDA-UHFFFAOYSA-N 50196525 CHEMBL3908863::US10167270, Compound 7f Lysosomal acid glucosylceramidase Homo sapiens 1120 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196525&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168100 375977482 CHEMBL3908863 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605218 C1Cc2ccccc2C[C@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m0/s1 NNXTWWKGCDOEQE-IBGZPJMESA-N 50196514 CHEMBL3950881::US10167270, Example 00159 Lysosomal acid glucosylceramidase Homo sapiens 6.00 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196514&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168030 375977471 CHEMBL3950881 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605219 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 10.00 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605220 C(C1CCCCN1c1nc(nc2ccccc12)-c1cccnc1)c1ccccc1 InChI=1S/C25H24N4/c1-2-9-19(10-3-1)17-21-12-6-7-16-29(21)25-22-13-4-5-14-23(22)27-24(28-25)20-11-8-15-26-18-20/h1-5,8-11,13-15,18,21H,6-7,12,16-17H2 QOKDUQAMXSDZIX-UHFFFAOYSA-N 313304 US10167270, Example 83 Lysosomal acid glucosylceramidase Homo sapiens 2240 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313304&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168087 383540211 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605221 CN([C@H]1CCc2ccccc2C1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C24H22N4/c1-28(20-13-12-17-7-2-3-8-18(17)15-20)24-21-10-4-5-11-22(21)26-23(27-24)19-9-6-14-25-16-19/h2-11,14,16,20H,12-13,15H2,1H3/t20-/m0/s1 VQHVGTSGQUJEJG-FQEVSTJZSA-N 313305 US10167270, Example 84 Lysosomal acid glucosylceramidase Homo sapiens 500 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313305&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168088 383540212 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605222 CC1(C)CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-21(2)11-9-16(10-12-21)23-20-17-7-3-4-8-18(17)24-19(25-20)15-6-5-13-22-14-15/h3-8,13-14,16H,9-12H2,1-2H3,(H,23,24,25) HSPJNLGHEQYSQA-UHFFFAOYSA-N 50196533 CHEMBL3894465::US10167270, Compound 6e Lysosomal acid glucosylceramidase Homo sapiens 460 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196533&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168446 375977490 CHEMBL3894465 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605223 CC1CCCC(C1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-14-6-4-8-16(12-14)22-20-17-9-2-3-10-18(17)23-19(24-20)15-7-5-11-21-13-15/h2-3,5,7,9-11,13-14,16H,4,6,8,12H2,1H3,(H,22,23,24) YQXNIQJKNVXEHM-UHFFFAOYSA-N 313308 US10167270, Example 86 Lysosomal acid glucosylceramidase Homo sapiens 79.0 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313308&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168026 383540215 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605224 C(C1CCCN(C1)c1nc(nc2ccccc12)-c1cccnc1)c1ccccc1 InChI=1S/C25H24N4/c1-2-8-19(9-3-1)16-20-10-7-15-29(18-20)25-22-12-4-5-13-23(22)27-24(28-25)21-11-6-14-26-17-21/h1-6,8-9,11-14,17,20H,7,10,15-16,18H2 CHOMWNJGXVFLQV-UHFFFAOYSA-N 313309 US10167270, Example 87 Lysosomal acid glucosylceramidase Homo sapiens 2510 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313309&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168346 383540216 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605225 Ic1ccc2CC(Cc2c1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H17IN4/c23-17-8-7-14-11-18(12-16(14)10-17)25-22-19-5-1-2-6-20(19)26-21(27-22)15-4-3-9-24-13-15/h1-10,13,18H,11-12H2,(H,25,26,27) XNEAFYCHQVFJGP-UHFFFAOYSA-N 313312 US10167270, Example 89 Lysosomal acid glucosylceramidase Homo sapiens 168 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313312&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168447 383540218 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605226 C1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C19H20N4/c1-2-8-15(9-3-1)21-19-16-10-4-5-11-17(16)22-18(23-19)14-7-6-12-20-13-14/h4-7,10-13,15H,1-3,8-9H2,(H,21,22,23) VTJDAALCLRKSIX-UHFFFAOYSA-N 50196518 CHEMBL3920301::US10167270, Compound 4 Lysosomal acid glucosylceramidase Homo sapiens 177 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196518&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 873720 375977475 CHEMBL3920301 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605227 CC1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-14-8-10-16(11-9-14)22-20-17-6-2-3-7-18(17)23-19(24-20)15-5-4-12-21-13-15/h2-7,12-14,16H,8-11H2,1H3,(H,22,23,24) ZIBKSPGRIZLUEF-UHFFFAOYSA-N 50196535 CHEMBL3948124::US10167270, Compound 6a Lysosomal acid glucosylceramidase Homo sapiens 56.0 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196535&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4965949 375977492 CHEMBL3948124 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605228 CCC1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-2-15-9-11-17(12-10-15)23-21-18-7-3-4-8-19(18)24-20(25-21)16-6-5-13-22-14-16/h3-8,13-15,17H,2,9-12H2,1H3,(H,23,24,25) NSUPJZHPKLIZHG-UHFFFAOYSA-N 50196627 CHEMBL3929224::US10167270, Compound 6b Lysosomal acid glucosylceramidase Homo sapiens 126 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196627&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168443 375977499 CHEMBL3929224 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605229 C[C@H]1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-14-8-10-16(11-9-14)22-20-17-6-2-3-7-18(17)23-19(24-20)15-5-4-12-21-13-15/h2-7,12-14,16H,8-11H2,1H3,(H,22,23,24)/t14-,16? ZIBKSPGRIZLUEF-GBANJREWSA-N 313316 US10167270, Compound 6c Lysosomal acid glucosylceramidase Homo sapiens 20.0 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313316&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4965949 383540222 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605230 COC1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4O/c1-25-16-10-8-15(9-11-16)22-20-17-6-2-3-7-18(17)23-19(24-20)14-5-4-12-21-13-14/h2-7,12-13,15-16H,8-11H2,1H3,(H,22,23,24) KHUIQQWXJGLXHU-UHFFFAOYSA-N 50196633 CHEMBL3965871::US10167270, Compound 6d Lysosomal acid glucosylceramidase Homo sapiens 251 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196633&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168347 375977504 CHEMBL3965871 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605231 CC1(C)CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-21(2)11-9-16(10-12-21)23-20-17-7-3-4-8-18(17)24-19(25-20)15-6-5-13-22-14-15/h3-8,13-14,16H,9-12H2,1-2H3,(H,23,24,25) HSPJNLGHEQYSQA-UHFFFAOYSA-N 50196533 CHEMBL3894465::US10167270, Compound 6e Lysosomal acid glucosylceramidase Homo sapiens 431 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196533&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168446 375977490 CHEMBL3894465 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605232 FC1(F)CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C19H18F2N4/c20-19(21)9-7-14(8-10-19)23-18-15-5-1-2-6-16(15)24-17(25-18)13-4-3-11-22-12-13/h1-6,11-12,14H,7-10H2,(H,23,24,25) GQSVORBZXSEUJW-UHFFFAOYSA-N 50196517 CHEMBL3980248::US10167270, Compound 6f Lysosomal acid glucosylceramidase Homo sapiens 234 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196517&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168022 375977474 CHEMBL3980248 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605233 C1COCC(C1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C18H18N4O/c1-2-8-16-15(7-1)18(20-14-6-4-10-23-12-14)22-17(21-16)13-5-3-9-19-11-13/h1-3,5,7-9,11,14H,4,6,10,12H2,(H,20,21,22) NSTBSEQCWALGQL-UHFFFAOYSA-N 50196632 CHEMBL3921895::US10167270, Compound 6h Lysosomal acid glucosylceramidase Homo sapiens 891 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196632&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168199 375977503 CHEMBL3921895 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605234 CC(C)N1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H25N5/c1-15(2)26-12-9-17(10-13-26)23-21-18-7-3-4-8-19(18)24-20(25-21)16-6-5-11-22-14-16/h3-8,11,14-15,17H,9-10,12-13H2,1-2H3,(H,23,24,25) ZAMRXVJIXGJERV-UHFFFAOYSA-N 50196532 CHEMBL3912910::US10167270, Compound 6j Lysosomal acid glucosylceramidase Homo sapiens 33210 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196532&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16355345 375977489 CHEMBL3912910 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605235 C(N1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1)c1ccccc1 InChI=1S/C25H25N5/c1-2-7-19(8-3-1)18-30-15-12-21(13-16-30)27-25-22-10-4-5-11-23(22)28-24(29-25)20-9-6-14-26-17-20/h1-11,14,17,21H,12-13,15-16,18H2,(H,27,28,29) FPSNRFFFQDOELT-UHFFFAOYSA-N 50196625 CHEMBL1405704::US10167270, Compound 6k Lysosomal acid glucosylceramidase Homo sapiens 36070 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196625&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 4882879 375977497 CHEMBL1405704 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605236 C1CCCC(CCC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-2-4-10-17(11-5-3-1)23-21-18-12-6-7-13-19(18)24-20(25-21)16-9-8-14-22-15-16/h6-9,12-15,17H,1-5,10-11H2,(H,23,24,25) KPHDEGYZCGJLCL-UHFFFAOYSA-N 50196531 CHEMBL3964444::US10167270, Compound 7a Lysosomal acid glucosylceramidase Homo sapiens 27.0 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196531&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17546054 375977488 CHEMBL3964444 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605237 C1CCCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-2-4-10-16(9-3-1)22-20-17-11-5-6-12-18(17)23-19(24-20)15-8-7-13-21-14-15/h5-8,11-14,16H,1-4,9-10H2,(H,22,23,24) REYRWOJVPIEDER-UHFFFAOYSA-N 50196530 CHEMBL3974789::US10167270, Compound 7b Lysosomal acid glucosylceramidase Homo sapiens 42.0 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196530&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2456688 375977487 CHEMBL3974789 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605238 C1CCC(C1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C18H18N4/c1-2-8-14(7-1)20-18-15-9-3-4-10-16(15)21-17(22-18)13-6-5-11-19-12-13/h3-6,9-12,14H,1-2,7-8H2,(H,20,21,22) WRPPYAYLCGHEDY-UHFFFAOYSA-N 50196516 CHEMBL3968279::US10167270, Compound 7c Lysosomal acid glucosylceramidase Homo sapiens 720 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196516&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17391397 375977473 CHEMBL3968279 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605239 C1CC(C1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C17H16N4/c1-2-9-15-14(8-1)17(19-13-6-3-7-13)21-16(20-15)12-5-4-10-18-11-12/h1-2,4-5,8-11,13H,3,6-7H2,(H,19,20,21) WBKIOFACQKHWCN-UHFFFAOYSA-N 50196520 CHEMBL3944808::US10167270, Compound 7d Lysosomal acid glucosylceramidase Homo sapiens 2840 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196520&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168092 375977477 CHEMBL3944808 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605240 C1CC1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C16H14N4/c1-2-6-14-13(5-1)16(18-12-7-8-12)20-15(19-14)11-4-3-9-17-10-11/h1-6,9-10,12H,7-8H2,(H,18,19,20) ZYMFUDCVHZLPBA-UHFFFAOYSA-N 50196529 CHEMBL3979185::US10167270, Compound 7e Lysosomal acid glucosylceramidase Homo sapiens 28070 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196529&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 8080175 375977486 CHEMBL3979185 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605241 C1C2CC3CC1CC(C2)(C3)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H24N4/c1-2-6-20-19(5-1)22(26-21(25-20)18-4-3-7-24-14-18)27-23-11-15-8-16(12-23)10-17(9-15)13-23/h1-7,14-17H,8-13H2,(H,25,26,27) LEWAHVWACBZCDA-UHFFFAOYSA-N 50196525 CHEMBL3908863::US10167270, Compound 7f Lysosomal acid glucosylceramidase Homo sapiens 926 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196525&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168100 375977482 CHEMBL3908863 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605242 C1CC2CC1CC2Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H20N4/c1-2-6-17-16(5-1)20(23-18-11-13-7-8-14(18)10-13)24-19(22-17)15-4-3-9-21-12-15/h1-6,9,12-14,18H,7-8,10-11H2,(H,22,23,24) FPKKVYLMXWIWLV-UHFFFAOYSA-N 50196635 CHEMBL3970989::US10167270, Compound 7g Lysosomal acid glucosylceramidase Homo sapiens 282 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196635&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168197 375977506 CHEMBL3970989 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605243 C(Nc1nc(nc2ccccc12)-c1cccnc1)C1CCCCC1 InChI=1S/C20H22N4/c1-2-7-15(8-3-1)13-22-20-17-10-4-5-11-18(17)23-19(24-20)16-9-6-12-21-14-16/h4-6,9-12,14-15H,1-3,7-8,13H2,(H,22,23,24) VADSISQHMHUCOP-UHFFFAOYSA-N 50196624 CHEMBL3963682::US10167270, Compound 7h Lysosomal acid glucosylceramidase Homo sapiens 405 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196624&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 21808535 375977496 CHEMBL3963682 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605244 C(CC1CCCCC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-2-7-16(8-3-1)12-14-23-21-18-10-4-5-11-19(18)24-20(25-21)17-9-6-13-22-15-17/h4-6,9-11,13,15-16H,1-3,7-8,12,14H2,(H,23,24,25) HDBYPZURDNCVJI-UHFFFAOYSA-N 50196631 CHEMBL3898722::US10167270, Compound 7i Lysosomal acid glucosylceramidase Homo sapiens 857 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196631&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168444 375977502 CHEMBL3898722 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605245 C(Nc1nc(nc2ccccc12)-c1cccnc1)c1ccccc1 InChI=1S/C20H16N4/c1-2-7-15(8-3-1)13-22-20-17-10-4-5-11-18(17)23-19(24-20)16-9-6-12-21-14-16/h1-12,14H,13H2,(H,22,23,24) AELMNLIYFALJIR-UHFFFAOYSA-N 50033284 Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine::CHEMBL119841::US10167270, Compound 8b::cid_667555 Lysosomal acid glucosylceramidase Homo sapiens 5770 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033284&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 667555 103941601 CHEMBL119841 ZINC00005903 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605246 C(Cc1ccccc1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H18N4/c1-2-7-16(8-3-1)12-14-23-21-18-10-4-5-11-19(18)24-20(25-21)17-9-6-13-22-15-17/h1-11,13,15H,12,14H2,(H,23,24,25) UWQNTLVHUVARDK-UHFFFAOYSA-N 50033286 CHEMBL544818::Phenethyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine; dihydrochloride::US10167270, Compound 8c Lysosomal acid glucosylceramidase Homo sapiens 97.0 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033286&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 874599 103941603 CHEMBL544818 ZINC00442667 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605247 C(CNc1nc(nc2ccccc12)-c1cccnc1)Cc1ccccc1 InChI=1S/C22H20N4/c1-2-8-17(9-3-1)10-6-15-24-22-19-12-4-5-13-20(19)25-21(26-22)18-11-7-14-23-16-18/h1-5,7-9,11-14,16H,6,10,15H2,(H,24,25,26) KNPAHIAFSKZRIB-UHFFFAOYSA-N 50196630 CHEMBL3942452::US10167270, Compound 8d Lysosomal acid glucosylceramidase Homo sapiens 1530 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196630&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168417 375977501 CHEMBL3942452 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605248 C(CCc1ccccc1)CNc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H22N4/c1-2-9-18(10-3-1)11-6-7-16-25-23-20-13-4-5-14-21(20)26-22(27-23)19-12-8-15-24-17-19/h1-5,8-10,12-15,17H,6-7,11,16H2,(H,25,26,27) LXPSTEYVBFGHEM-UHFFFAOYSA-N 50196626 CHEMBL3972062::US10167270, Compound 8e Lysosomal acid glucosylceramidase Homo sapiens 1280 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196626&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168418 375977498 CHEMBL3972062 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605249 C(Cc1ccccn1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H17N5/c1-2-9-18-17(8-1)20(23-13-10-16-7-3-4-12-22-16)25-19(24-18)15-6-5-11-21-14-15/h1-9,11-12,14H,10,13H2,(H,23,24,25) XDSFFKXQUALAPV-UHFFFAOYSA-N 50196515 CHEMBL3913022::US10167270, Compound 8f Lysosomal acid glucosylceramidase Homo sapiens 1400 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196515&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9282942 375977472 CHEMBL3913022 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605250 C(Cc1cccnc1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H17N5/c1-2-8-18-17(7-1)20(23-12-9-15-5-3-10-21-13-15)25-19(24-18)16-6-4-11-22-14-16/h1-8,10-11,13-14H,9,12H2,(H,23,24,25) UKYOLERGWNZMQS-UHFFFAOYSA-N 50196523 CHEMBL3914158::US10167270, Compound 8g Lysosomal acid glucosylceramidase Homo sapiens 4290 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196523&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 31408646 375977480 CHEMBL3914158 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605251 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 8.70 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605252 C1Cc2ccccc2C[C@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m0/s1 NNXTWWKGCDOEQE-IBGZPJMESA-N 50196514 CHEMBL3950881::US10167270, Example 00159 Lysosomal acid glucosylceramidase Homo sapiens 9.90 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196514&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168030 375977471 CHEMBL3950881 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605253 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-7-16-13-18(12-15(16)6-1)24-22-19-9-3-4-10-20(19)25-21(26-22)17-8-5-11-23-14-17/h1-11,14,18H,12-13H2,(H,24,25,26) XXCCBJLQMRHXKM-UHFFFAOYSA-N 50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c Lysosomal acid glucosylceramidase Homo sapiens 8.30 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168025 375977485 CHEMBL3923120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605254 C1CC(Nc2nc(nc3ccccc23)-c2cccnc2)c2ccccc2C1 InChI=1S/C23H20N4/c1-2-10-18-16(7-1)8-5-13-20(18)26-23-19-11-3-4-12-21(19)25-22(27-23)17-9-6-14-24-15-17/h1-4,6-7,9-12,14-15,20H,5,8,13H2,(H,25,26,27) XGFDEYBZTPSJCH-UHFFFAOYSA-N 50196628 CHEMBL3932095::US10167270, Compound 9d Lysosomal acid glucosylceramidase Homo sapiens 872 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196628&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168445 375977500 CHEMBL3932095 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605255 C1Cc2ccccc2C1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-8-17-15(6-1)11-12-20(17)25-22-18-9-3-4-10-19(18)24-21(26-22)16-7-5-13-23-14-16/h1-10,13-14,20H,11-12H2,(H,24,25,26) NHFIHEPUGCTNFM-UHFFFAOYSA-N 50196527 CHEMBL3970658::US10167270, Compound 9e Lysosomal acid glucosylceramidase Homo sapiens 821 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196527&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17518657 375977484 CHEMBL3970658 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605256 Cc1ccncc1-c1nc(NC2Cc3ccccc3C2)c2ccccc2n1 InChI=1S/C23H20N4/c1-15-10-11-24-14-20(15)23-26-21-9-5-4-8-19(21)22(27-23)25-18-12-16-6-2-3-7-17(16)13-18/h2-11,14,18H,12-13H2,1H3,(H,25,26,27) IZELJCTXEFPJGK-UHFFFAOYSA-N 50196536 CHEMBL3906252::US10167270, Compound 11a Lysosomal acid glucosylceramidase Homo sapiens 122 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196536&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134134697 375977493 CHEMBL3906252 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605257 Cc1cncc(c1)-c1nc(NC2Cc3ccccc3C2)c2ccccc2n1 InChI=1S/C23H20N4/c1-15-10-18(14-24-13-15)22-26-21-9-5-4-8-20(21)23(27-22)25-19-11-16-6-2-3-7-17(16)12-19/h2-10,13-14,19H,11-12H2,1H3,(H,25,26,27) SKNLOHJCCVGXLC-UHFFFAOYSA-N 50196634 CHEMBL3976949::US10167270, Compound 11b Lysosomal acid glucosylceramidase Homo sapiens 12.5 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196634&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134152584 375977505 CHEMBL3976949 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605258 Cc1ccc(cn1)-c1nc(NC2Cc3ccccc3C2)c2ccccc2n1 InChI=1S/C23H20N4/c1-15-10-11-18(14-24-15)22-26-21-9-5-4-8-20(21)23(27-22)25-19-12-16-6-2-3-7-17(16)13-19/h2-11,14,19H,12-13H2,1H3,(H,25,26,27) SNPORVMVKFFDMI-UHFFFAOYSA-N 50196524 CHEMBL3968646::US10167270, Compound 11c Lysosomal acid glucosylceramidase Homo sapiens 29.4 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196524&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134150037 375977481 CHEMBL3968646 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605259 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C23H19N3/c1-2-8-16(9-3-1)22-25-21-13-7-6-12-20(21)23(26-22)24-19-14-17-10-4-5-11-18(17)15-19/h1-13,19H,14-15H2,(H,24,25,26) DCLFPHIXBNDNBF-UHFFFAOYSA-N 50196521 CHEMBL3939100::US10167270, Example 00162::US10501435, Compound 11d Lysosomal acid glucosylceramidase Homo sapiens 6.50 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196521&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168420 375977478 CHEMBL3939100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605260 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccncc1 InChI=1S/C22H18N4/c1-2-6-17-14-18(13-16(17)5-1)24-22-19-7-3-4-8-20(19)25-21(26-22)15-9-11-23-12-10-15/h1-12,18H,13-14H2,(H,24,25,26) CXXZGJGTXABPOP-UHFFFAOYSA-N 50196522 CHEMBL3957610::US10167270, Compound 11e Lysosomal acid glucosylceramidase Homo sapiens 168 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196522&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134154906 375977479 CHEMBL3957610 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605261 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccs1 InChI=1S/C21H17N3S/c1-2-7-15-13-16(12-14(15)6-1)22-20-17-8-3-4-9-18(17)23-21(24-20)19-10-5-11-25-19/h1-11,16H,12-13H2,(H,22,23,24) YIFJXSPQCBCHCI-UHFFFAOYSA-N 50196519 CHEMBL3930102::US10167270, Example 00163::US10501435, Compound 11f Lysosomal acid glucosylceramidase Homo sapiens 8.20 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196519&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168091 375977476 CHEMBL3930102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605262 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccsc1 InChI=1S/C21H17N3S/c1-2-6-15-12-17(11-14(15)5-1)22-21-18-7-3-4-8-19(18)23-20(24-21)16-9-10-25-13-16/h1-10,13,17H,11-12H2,(H,22,23,24) JCDASFBLAYXAIQ-UHFFFAOYSA-N 50196623 CHEMBL3976182::US10167270, Example 00164::US10501435, Compound 11g Lysosomal acid glucosylceramidase Homo sapiens 5.20 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196623&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168348 375977495 CHEMBL3976182 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605263 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccco1 InChI=1S/C21H17N3O/c1-2-7-15-13-16(12-14(15)6-1)22-20-17-8-3-4-9-18(17)23-21(24-20)19-10-5-11-25-19/h1-11,16H,12-13H2,(H,22,23,24) NZSRNECXKGBZCA-UHFFFAOYSA-N 50196610 CHEMBL3956552::US10167270, Compound 11h Lysosomal acid glucosylceramidase Homo sapiens 21.1 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196610&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 134143870 104078326 CHEMBL3956552 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605264 C1Cc2ccccc2C[C@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m0/s1 NNXTWWKGCDOEQE-IBGZPJMESA-N 50196514 CHEMBL3950881::US10167270, Example 00159 Lysosomal acid glucosylceramidase Homo sapiens 22.4 US Patent 10.7270/Q2862JH8 aid1796433 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196514&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168030 375977471 CHEMBL3950881 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605265 C1Cc2ccccc2C[C@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m0/s1 NNXTWWKGCDOEQE-IBGZPJMESA-N 50196514 CHEMBL3950881::US10167270, Example 00159 Lysosomal acid glucosylceramidase Homo sapiens 8.70 US Patent 10.7270/Q2862JH8 aid1796434 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196514&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168030 375977471 CHEMBL3950881 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605266 C1Cc2ccccc2C[C@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m0/s1 NNXTWWKGCDOEQE-IBGZPJMESA-N 50196514 CHEMBL3950881::US10167270, Example 00159 Lysosomal acid glucosylceramidase Homo sapiens 16.9 US Patent 10.7270/Q2862JH8 aid1796435 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196514&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168030 375977471 CHEMBL3950881 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605267 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 30.1 US Patent 10.7270/Q2862JH8 aid1796433 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605268 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 9.90 US Patent 10.7270/Q2862JH8 aid1796434 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605269 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 18.8 US Patent 10.7270/Q2862JH8 aid1796435 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605270 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-7-16-13-18(12-15(16)6-1)24-22-19-9-3-4-10-20(19)25-21(26-22)17-8-5-11-23-14-17/h1-11,14,18H,12-13H2,(H,24,25,26) XXCCBJLQMRHXKM-UHFFFAOYSA-N 50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c Lysosomal acid glucosylceramidase Homo sapiens 25.9 US Patent 10.7270/Q2862JH8 aid1796433 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168025 375977485 CHEMBL3923120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605271 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-7-16-13-18(12-15(16)6-1)24-22-19-9-3-4-10-20(19)25-21(26-22)17-8-5-11-23-14-17/h1-11,14,18H,12-13H2,(H,24,25,26) XXCCBJLQMRHXKM-UHFFFAOYSA-N 50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c Lysosomal acid glucosylceramidase Homo sapiens 8.30 US Patent 10.7270/Q2862JH8 aid1796434 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168025 375977485 CHEMBL3923120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605272 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-7-16-13-18(12-15(16)6-1)24-22-19-9-3-4-10-20(19)25-21(26-22)17-8-5-11-23-14-17/h1-11,14,18H,12-13H2,(H,24,25,26) XXCCBJLQMRHXKM-UHFFFAOYSA-N 50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c Lysosomal acid glucosylceramidase Homo sapiens 12.7 US Patent 10.7270/Q2862JH8 aid1796435 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168025 375977485 CHEMBL3923120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605273 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C23H19N3/c1-2-8-16(9-3-1)22-25-21-13-7-6-12-20(21)23(26-22)24-19-14-17-10-4-5-11-18(17)15-19/h1-13,19H,14-15H2,(H,24,25,26) DCLFPHIXBNDNBF-UHFFFAOYSA-N 50196521 CHEMBL3939100::US10167270, Example 00162::US10501435, Compound 11d Lysosomal acid glucosylceramidase Homo sapiens 10.5 US Patent 10.7270/Q2862JH8 aid1796433 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196521&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168420 375977478 CHEMBL3939100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605274 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C23H19N3/c1-2-8-16(9-3-1)22-25-21-13-7-6-12-20(21)23(26-22)24-19-14-17-10-4-5-11-18(17)15-19/h1-13,19H,14-15H2,(H,24,25,26) DCLFPHIXBNDNBF-UHFFFAOYSA-N 50196521 CHEMBL3939100::US10167270, Example 00162::US10501435, Compound 11d Lysosomal acid glucosylceramidase Homo sapiens 6.50 US Patent 10.7270/Q2862JH8 aid1796434 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196521&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168420 375977478 CHEMBL3939100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605275 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C23H19N3/c1-2-8-16(9-3-1)22-25-21-13-7-6-12-20(21)23(26-22)24-19-14-17-10-4-5-11-18(17)15-19/h1-13,19H,14-15H2,(H,24,25,26) DCLFPHIXBNDNBF-UHFFFAOYSA-N 50196521 CHEMBL3939100::US10167270, Example 00162::US10501435, Compound 11d Lysosomal acid glucosylceramidase Homo sapiens 9.40 US Patent 10.7270/Q2862JH8 aid1796435 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196521&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168420 375977478 CHEMBL3939100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605276 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccs1 InChI=1S/C21H17N3S/c1-2-7-15-13-16(12-14(15)6-1)22-20-17-8-3-4-9-18(17)23-21(24-20)19-10-5-11-25-19/h1-11,16H,12-13H2,(H,22,23,24) YIFJXSPQCBCHCI-UHFFFAOYSA-N 50196519 CHEMBL3930102::US10167270, Example 00163::US10501435, Compound 11f Lysosomal acid glucosylceramidase Homo sapiens 13.9 US Patent 10.7270/Q2862JH8 aid1796433 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196519&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168091 375977476 CHEMBL3930102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605277 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccs1 InChI=1S/C21H17N3S/c1-2-7-15-13-16(12-14(15)6-1)22-20-17-8-3-4-9-18(17)23-21(24-20)19-10-5-11-25-19/h1-11,16H,12-13H2,(H,22,23,24) YIFJXSPQCBCHCI-UHFFFAOYSA-N 50196519 CHEMBL3930102::US10167270, Example 00163::US10501435, Compound 11f Lysosomal acid glucosylceramidase Homo sapiens 8.20 US Patent 10.7270/Q2862JH8 aid1796434 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196519&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168091 375977476 CHEMBL3930102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605278 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccs1 InChI=1S/C21H17N3S/c1-2-7-15-13-16(12-14(15)6-1)22-20-17-8-3-4-9-18(17)23-21(24-20)19-10-5-11-25-19/h1-11,16H,12-13H2,(H,22,23,24) YIFJXSPQCBCHCI-UHFFFAOYSA-N 50196519 CHEMBL3930102::US10167270, Example 00163::US10501435, Compound 11f Lysosomal acid glucosylceramidase Homo sapiens 12.9 US Patent 10.7270/Q2862JH8 aid1796435 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196519&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168091 375977476 CHEMBL3930102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605279 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccsc1 InChI=1S/C21H17N3S/c1-2-6-15-12-17(11-14(15)5-1)22-21-18-7-3-4-8-19(18)23-20(24-21)16-9-10-25-13-16/h1-10,13,17H,11-12H2,(H,22,23,24) JCDASFBLAYXAIQ-UHFFFAOYSA-N 50196623 CHEMBL3976182::US10167270, Example 00164::US10501435, Compound 11g Lysosomal acid glucosylceramidase Homo sapiens 8.90 US Patent 10.7270/Q2862JH8 aid1796433 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196623&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168348 375977495 CHEMBL3976182 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605280 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccsc1 InChI=1S/C21H17N3S/c1-2-6-15-12-17(11-14(15)5-1)22-21-18-7-3-4-8-19(18)23-20(24-21)16-9-10-25-13-16/h1-10,13,17H,11-12H2,(H,22,23,24) JCDASFBLAYXAIQ-UHFFFAOYSA-N 50196623 CHEMBL3976182::US10167270, Example 00164::US10501435, Compound 11g Lysosomal acid glucosylceramidase Homo sapiens 5.20 US Patent 10.7270/Q2862JH8 aid1796434 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196623&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168348 375977495 CHEMBL3976182 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605281 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccsc1 InChI=1S/C21H17N3S/c1-2-6-15-12-17(11-14(15)5-1)22-21-18-7-3-4-8-19(18)23-20(24-21)16-9-10-25-13-16/h1-10,13,17H,11-12H2,(H,22,23,24) JCDASFBLAYXAIQ-UHFFFAOYSA-N 50196623 CHEMBL3976182::US10167270, Example 00164::US10501435, Compound 11g Lysosomal acid glucosylceramidase Homo sapiens 6.60 US Patent 10.7270/Q2862JH8 aid1796435 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196623&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168348 375977495 CHEMBL3976182 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605282 Cc1ccc(OCCNc2nc(nc3ccccc23)-c2cccnc2)cc1 InChI=1S/C22H20N4O/c1-16-8-10-18(11-9-16)27-14-13-24-22-19-6-2-3-7-20(19)25-21(26-22)17-5-4-12-23-15-17/h2-12,15H,13-14H2,1H3,(H,24,25,26) OHAWNISCEYVGEK-UHFFFAOYSA-N 313410 US10167270, Example 90 Lysosomal acid glucosylceramidase Homo sapiens 620 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313410&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168421 383540310 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605283 C(CNc1nc(nc2ccccc12)-c1cccnc1)COc1ccccc1 InChI=1S/C22H20N4O/c1-2-9-18(10-3-1)27-15-7-14-24-22-19-11-4-5-12-20(19)25-21(26-22)17-8-6-13-23-16-17/h1-6,8-13,16H,7,14-15H2,(H,24,25,26) XDCRBXWHGJURAB-UHFFFAOYSA-N 313411 US10167270, Example 91 Lysosomal acid glucosylceramidase Homo sapiens 2820 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313411&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168422 383540311 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605284 CC(CNc1nc(nc2ccccc12)-c1cccnc1)Oc1ccccc1 InChI=1S/C22H20N4O/c1-16(27-18-9-3-2-4-10-18)14-24-22-19-11-5-6-12-20(19)25-21(26-22)17-8-7-13-23-15-17/h2-13,15-16H,14H2,1H3,(H,24,25,26) RKKRWKMFEZFLPD-UHFFFAOYSA-N 313412 US10167270, Example 92 Lysosomal acid glucosylceramidase Homo sapiens 5010 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313412&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168033 383540312 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605285 C1Cc2[nH]c3ccccc3c2CN1c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C24H19N5/c1-3-9-20-17(7-1)19-15-29(13-11-22(19)26-20)24-18-8-2-4-10-21(18)27-23(28-24)16-6-5-12-25-14-16/h1-10,12,14,26H,11,13,15H2 AVNFYQOUAKVMFG-UHFFFAOYSA-N 313413 US10167270, Example 93 Lysosomal acid glucosylceramidase Homo sapiens 6310 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313413&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168423 383540313 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605286 C1Cc2c(CN1c1nc(nc3ccccc13)-c1cccnc1)[nH]c1ccccc21 InChI=1S/C24H19N5/c1-3-9-20-17(7-1)18-11-13-29(15-22(18)26-20)24-19-8-2-4-10-21(19)27-23(28-24)16-6-5-12-25-14-16/h1-10,12,14,26H,11,13,15H2 NFXDNLZXRXQIFM-UHFFFAOYSA-N 313414 US10167270, Example 94 Lysosomal acid glucosylceramidase Homo sapiens 2820 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313414&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168035 383540314 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605287 CCCCCCCCNc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H26N4/c1-2-3-4-5-6-9-15-23-21-18-12-7-8-13-19(18)24-20(25-21)17-11-10-14-22-16-17/h7-8,10-14,16H,2-6,9,15H2,1H3,(H,23,24,25) KRQAWALWSXBCQE-UHFFFAOYSA-N 313415 US10167270, Example 95 Lysosomal acid glucosylceramidase Homo sapiens 2240 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313415&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168424 383540315 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605288 CC(C)(C)OC(=O)NCCC#Cc1ccc2CC(Cc2c1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C31H31N5O2/c1-31(2,3)38-30(37)33-16-7-6-9-21-13-14-22-18-25(19-24(22)17-21)34-29-26-11-4-5-12-27(26)35-28(36-29)23-10-8-15-32-20-23/h4-5,8,10-15,17,20,25H,7,16,18-19H2,1-3H3,(H,33,37)(H,34,35,36) UAQZUGNCXFGOGL-UHFFFAOYSA-N 313416 US10167270, Example 96 Lysosomal acid glucosylceramidase Homo sapiens 560 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313416&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124172247 383540316 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605289 CC(COc1ccccc1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H20N4O/c1-16(15-27-18-9-3-2-4-10-18)24-22-19-11-5-6-12-20(19)25-21(26-22)17-8-7-13-23-14-17/h2-14,16H,15H2,1H3,(H,24,25,26) KSCVPWHRGWZLOT-UHFFFAOYSA-N 313417 US10167270, Example 97 Lysosomal acid glucosylceramidase Homo sapiens 2510 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313417&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168350 383540317 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605290 Oc1ccc2CC[C@@H](Cc2c1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4O/c28-19-10-8-15-7-9-18(12-17(15)13-19)25-23-20-5-1-2-6-21(20)26-22(27-23)16-4-3-11-24-14-16/h1-6,8,10-11,13-14,18,28H,7,9,12H2,(H,25,26,27)/t18-/m0/s1 QWBKYOWTGUYGRJ-SFHVURJKSA-N 313418 US10167270, Example 98 Lysosomal acid glucosylceramidase Homo sapiens 79.0 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313418&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168203 383540318 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605291 NCCC#Cc1ccc2CC(Cc2c1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C26H23N5/c27-12-4-3-6-18-10-11-19-15-22(16-21(19)14-18)29-26-23-8-1-2-9-24(23)30-25(31-26)20-7-5-13-28-17-20/h1-2,5,7-11,13-14,17,22H,4,12,15-16,27H2,(H,29,30,31) XSHDUMKSLWITRN-UHFFFAOYSA-N 313419 US10167270, Example 99 Lysosomal acid glucosylceramidase Homo sapiens 891 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313419&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168204 383540319 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605292 Brc1ccc2CC(Cc2c1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H17BrN4/c23-17-8-7-14-11-18(12-16(14)10-17)25-22-19-5-1-2-6-20(19)26-21(27-22)15-4-3-9-24-13-15/h1-10,13,18H,11-12H2,(H,25,26,27) CLEJOUIPUIOJOV-UHFFFAOYSA-N 313420 US10167270, Example 100 Lysosomal acid glucosylceramidase Homo sapiens 178 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313420&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168352 383540320 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605293 CN(CCOc1ccc(I)cc1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H19IN4O/c1-27(13-14-28-18-10-8-17(23)9-11-18)22-19-6-2-3-7-20(19)25-21(26-22)16-5-4-12-24-15-16/h2-12,15H,13-14H2,1H3 NJHDQXKCNJUWFS-UHFFFAOYSA-N 313421 US10167270, Example 107 Lysosomal acid glucosylceramidase Homo sapiens 6250 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313421&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168427 383540321 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605294 C(CCCCCNc1nc(nc2ccccc12)-c1cccnc1)CCCCNc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C36H38N8/c1(3-5-11-23-39-35-29-17-7-9-19-31(29)41-33(43-35)27-15-13-21-37-25-27)2-4-6-12-24-40-36-30-18-8-10-20-32(30)42-34(44-36)28-16-14-22-38-26-28/h7-10,13-22,25-26H,1-6,11-12,23-24H2,(H,39,41,43)(H,40,42,44) JJIFZYLZFKJYTN-UHFFFAOYSA-N 313422 US10167270, Example 108 Lysosomal acid glucosylceramidase Homo sapiens 141 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313422&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168206 383540322 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605295 CN(CCOc1ccc(cc1)C#CCCCCCCC#Cc1ccc(OCCN(C)c2nc(nc3ccccc23)-c2cccnc2)cc1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C54H50N8O2/c1-61(53-47-21-11-13-23-49(47)57-51(59-53)43-19-15-33-55-39-43)35-37-63-45-29-25-41(26-30-45)17-9-7-5-3-4-6-8-10-18-42-27-31-46(32-28-42)64-38-36-62(2)54-48-22-12-14-24-50(48)58-52(60-54)44-20-16-34-56-40-44/h11-16,19-34,39-40H,3-8,35-38H2,1-2H3 AWQLCOKRVYRTBO-UHFFFAOYSA-N 313423 US10167270, Example 111 Lysosomal acid glucosylceramidase Homo sapiens 35000 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313423&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168448 383540323 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605296 C#CCOCCOCCNc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H20N4O2/c1-2-11-25-13-14-26-12-10-22-20-17-7-3-4-8-18(17)23-19(24-20)16-6-5-9-21-15-16/h1,3-9,15H,10-14H2,(H,22,23,24) CSLIJXQVXOJIQE-UHFFFAOYSA-N 313424 US10167270, Example 113 Lysosomal acid glucosylceramidase Homo sapiens 12580 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313424&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168449 383540324 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605297 C1CN(Cc2ccccc2O1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4O/c1-4-10-20-17(6-1)15-26(12-13-27-20)22-18-8-2-3-9-19(18)24-21(25-22)16-7-5-11-23-14-16/h1-11,14H,12-13,15H2 IEHJLRNJUMTXCT-UHFFFAOYSA-N 313425 US10167270, Example 115 Lysosomal acid glucosylceramidase Homo sapiens 7940 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313425&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168034 383540325 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605298 COC(=O)CCCCCCCCCCc1ccc(OCCN(C)c2nc(nc3ccccc23)-c2cccnc2)cc1 InChI=1S/C34H42N4O3/c1-38(34-30-16-11-12-17-31(30)36-33(37-34)28-15-13-23-35-26-28)24-25-41-29-21-19-27(20-22-29)14-9-7-5-3-4-6-8-10-18-32(39)40-2/h11-13,15-17,19-23,26H,3-10,14,18,24-25H2,1-2H3 CIKUGCLSNIUDFN-UHFFFAOYSA-N 313426 US10167270, Example 117 Lysosomal acid glucosylceramidase Homo sapiens 7080 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313426&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168096 383540326 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605299 CN(C1CCCC1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C19H20N4/c1-23(15-8-2-3-9-15)19-16-10-4-5-11-17(16)21-18(22-19)14-7-6-12-20-13-14/h4-7,10-13,15H,2-3,8-9H2,1H3 UUQMSTYSSCYCIV-UHFFFAOYSA-N 313427 US10167270, Example 118 Lysosomal acid glucosylceramidase Homo sapiens 22380 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313427&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168036 383540327 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605300 CN(CCCc1ccccc1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H22N4/c1-27(16-8-11-18-9-3-2-4-10-18)23-20-13-5-6-14-21(20)25-22(26-23)19-12-7-15-24-17-19/h2-7,9-10,12-15,17H,8,11,16H2,1H3 XZRKSCSXGJXYFX-UHFFFAOYSA-N 313428 US10167270, Example 119 Lysosomal acid glucosylceramidase Homo sapiens 5010 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313428&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168210 383540328 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605301 CN(CCCCc1ccccc1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C24H24N4/c1-28(17-8-7-12-19-10-3-2-4-11-19)24-21-14-5-6-15-22(21)26-23(27-24)20-13-9-16-25-18-20/h2-6,9-11,13-16,18H,7-8,12,17H2,1H3 IJCHLSOUODSNEP-UHFFFAOYSA-N 313429 US10167270, Example 120 Lysosomal acid glucosylceramidase Homo sapiens 3160 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313429&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168353 383540329 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605302 CN(C1CCCCCC1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-25(17-10-4-2-3-5-11-17)21-18-12-6-7-13-19(18)23-20(24-21)16-9-8-14-22-15-16/h6-9,12-15,17H,2-5,10-11H2,1H3 ZJCRBOCVUBNQMZ-UHFFFAOYSA-N 313430 US10167270, Example 121 Lysosomal acid glucosylceramidase Homo sapiens 8910 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313430&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168429 383540330 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605303 CN(CCc1ccccc1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H20N4/c1-26(15-13-17-8-3-2-4-9-17)22-19-11-5-6-12-20(19)24-21(25-22)18-10-7-14-23-16-18/h2-12,14,16H,13,15H2,1H3 ABGLNIBKKUQOIN-UHFFFAOYSA-N 313431 US10167270, Example 122 Lysosomal acid glucosylceramidase Homo sapiens 5010 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313431&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168038 383540331 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605304 CN(CCOc1ccccc1)c1nc(Cl)nc2ccccc12 InChI=1S/C17H16ClN3O/c1-21(11-12-22-13-7-3-2-4-8-13)16-14-9-5-6-10-15(14)19-17(18)20-16/h2-10H,11-12H2,1H3 DZOGNRBELNUSRI-UHFFFAOYSA-N 313432 US10167270, Example 124 Lysosomal acid glucosylceramidase Homo sapiens 10000 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313432&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168211 383540332 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605305 CN(CCOc1ccccc1)c1nc(nc2ccccc12)-c1cncnc1 InChI=1S/C21H19N5O/c1-26(11-12-27-17-7-3-2-4-8-17)21-18-9-5-6-10-19(18)24-20(25-21)16-13-22-15-23-14-16/h2-10,13-15H,11-12H2,1H3 XWUVLZBOOOLDBW-UHFFFAOYSA-N 313433 US10167270, Example 127 Lysosomal acid glucosylceramidase Homo sapiens 1250 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313433&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168452 383540333 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605306 CN(CCOc1ccccc1)c1nc(nc2ccccc12)-c1ccccc1F InChI=1S/C23H20FN3O/c1-27(15-16-28-17-9-3-2-4-10-17)23-19-12-6-8-14-21(19)25-22(26-23)18-11-5-7-13-20(18)24/h2-14H,15-16H2,1H3 FLFLVESIKYUVHN-UHFFFAOYSA-N 313434 US10167270, Example 128 Lysosomal acid glucosylceramidase Homo sapiens 1250 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313434&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168355 383540334 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605307 CN(CCOc1ccccc1)c1nc(nc2ccccc12)-c1ccncc1 InChI=1S/C22H20N4O/c1-26(15-16-27-18-7-3-2-4-8-18)22-19-9-5-6-10-20(19)24-21(25-22)17-11-13-23-14-12-17/h2-14H,15-16H2,1H3 UPJYMERFIKQLSP-UHFFFAOYSA-N 313435 US10167270, Example 130 Lysosomal acid glucosylceramidase Homo sapiens 3980 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313435&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 40135844 383540335 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605308 CN(CCOc1ccccc1)c1nc(nc2ccccc12)-c1ccco1 InChI=1S/C21H19N3O2/c1-24(13-15-25-16-8-3-2-4-9-16)21-17-10-5-6-11-18(17)22-20(23-21)19-12-7-14-26-19/h2-12,14H,13,15H2,1H3 PVPHPHLCHCQZBF-UHFFFAOYSA-N 313436 US10167270, Example 133 Lysosomal acid glucosylceramidase Homo sapiens 31620 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313436&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168454 383540336 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605309 CN(CCOc1ccccc1)c1nc(nc2ccccc12)-c1ccoc1 InChI=1S/C21H19N3O2/c1-24(12-14-26-17-7-3-2-4-8-17)21-18-9-5-6-10-19(18)22-20(23-21)16-11-13-25-15-16/h2-11,13,15H,12,14H2,1H3 OEDJYSNEHYQMML-UHFFFAOYSA-N 313437 US10167270, Example 134 Lysosomal acid glucosylceramidase Homo sapiens 650 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313437&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168357 383540337 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605310 COc1ccccc1OCCN(C)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H22N4O2/c1-27(14-15-29-21-12-6-5-11-20(21)28-2)23-18-9-3-4-10-19(18)25-22(26-23)17-8-7-13-24-16-17/h3-13,16H,14-15H2,1-2H3 JDWYTIMBSQRLOO-UHFFFAOYSA-N 313438 US10167270, Example 135 Lysosomal acid glucosylceramidase Homo sapiens 2390 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313438&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168358 383540338 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605311 CN(CCOc1ccc(C)cc1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H22N4O/c1-17-9-11-19(12-10-17)28-15-14-27(2)23-20-7-3-4-8-21(20)25-22(26-23)18-6-5-13-24-16-18/h3-13,16H,14-15H2,1-2H3 QAPDLZXHEOZGRQ-UHFFFAOYSA-N 313439 US10167270, Example 136 Lysosomal acid glucosylceramidase Homo sapiens 3550 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313439&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168455 383540339 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605312 CN(CCCOc1ccccc1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H22N4O/c1-27(15-8-16-28-19-10-3-2-4-11-19)23-20-12-5-6-13-21(20)25-22(26-23)18-9-7-14-24-17-18/h2-7,9-14,17H,8,15-16H2,1H3 KVKCYJQCCLIGJK-UHFFFAOYSA-N 313440 US10167270, Example 137 Lysosomal acid glucosylceramidase Homo sapiens 5010 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313440&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 36790148 383540340 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605313 CC(CN(C)c1nc(nc2ccccc12)-c1cccnc1)Oc1ccccc1 InChI=1S/C23H22N4O/c1-17(28-19-10-4-3-5-11-19)16-27(2)23-20-12-6-7-13-21(20)25-22(26-23)18-9-8-14-24-15-18/h3-15,17H,16H2,1-2H3 QMFLTXUCJGWEFN-UHFFFAOYSA-N 313441 US10167270, Example 138 Lysosomal acid glucosylceramidase Homo sapiens 5620 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313441&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168041 383540341 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605314 CC(COc1ccccc1)N(C)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H22N4O/c1-17(16-28-19-10-4-3-5-11-19)27(2)23-20-12-6-7-13-21(20)25-22(26-23)18-9-8-14-24-15-18/h3-15,17H,16H2,1-2H3 NROINOAHJYRENU-UHFFFAOYSA-N 313442 US10167270, Example 139 Lysosomal acid glucosylceramidase Homo sapiens 5620 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313442&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168359 383540342 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605315 C(COCc1ccccc1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H20N4O/c1-2-7-17(8-3-1)16-27-14-13-24-22-19-10-4-5-11-20(19)25-21(26-22)18-9-6-12-23-15-18/h1-12,15H,13-14,16H2,(H,24,25,26) BBJKIYCPVMDVEB-UHFFFAOYSA-N 313443 US10167270, Example 140 Lysosomal acid glucosylceramidase Homo sapiens 11220 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313443&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168213 383540343 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605316 CN(CCOCc1ccccc1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H22N4O/c1-27(14-15-28-17-18-8-3-2-4-9-18)23-20-11-5-6-12-21(20)25-22(26-23)19-10-7-13-24-16-19/h2-13,16H,14-15,17H2,1H3 SIPGZEAUCVNPPT-UHFFFAOYSA-N 313444 US10167270, Example 141 Lysosomal acid glucosylceramidase Homo sapiens 11220 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313444&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168360 383540344 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605317 Nc1ccc(cc1)-c1nc(NC2Cc3ccccc3C2)c2ccccc2n1 InChI=1S/C23H20N4/c24-18-11-9-15(10-12-18)22-26-21-8-4-3-7-20(21)23(27-22)25-19-13-16-5-1-2-6-17(16)14-19/h1-12,19H,13-14,24H2,(H,25,26,27) XGHROEWWVNJOLI-UHFFFAOYSA-N 313445 US10167270, Example 142 Lysosomal acid glucosylceramidase Homo sapiens 7.10 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313445&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168362 383540345 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605318 CC(C)(C)OC(=O)NCCCCCC(=O)Nc1ccc(cc1)-c1nc(NC2Cc3ccccc3C2)c2ccccc2n1 InChI=1S/C34H39N5O3/c1-34(2,3)42-33(41)35-20-10-4-5-15-30(40)36-26-18-16-23(17-19-26)31-38-29-14-9-8-13-28(29)32(39-31)37-27-21-24-11-6-7-12-25(24)22-27/h6-9,11-14,16-19,27H,4-5,10,15,20-22H2,1-3H3,(H,35,41)(H,36,40)(H,37,38,39) IMWFXFHZTKSNCN-UHFFFAOYSA-N 313446 US10167270, Example 145 Lysosomal acid glucosylceramidase Homo sapiens 5.60 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313446&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124172254 383540346 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605319 CC(C)(C)OC(=O)NCCOCCOCC(=O)Nc1ccc(cc1)-c1nc(NC2Cc3ccccc3C2)c2ccccc2n1 InChI=1S/C34H39N5O5/c1-34(2,3)44-33(41)35-16-17-42-18-19-43-22-30(40)36-26-14-12-23(13-15-26)31-38-29-11-7-6-10-28(29)32(39-31)37-27-20-24-8-4-5-9-25(24)21-27/h4-15,27H,16-22H2,1-3H3,(H,35,41)(H,36,40)(H,37,38,39) AKCYFKQSFBIMQT-UHFFFAOYSA-N 313447 US10167270, Example 146 Lysosomal acid glucosylceramidase Homo sapiens 39.8 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313447&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124172252 383540347 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605320 NCCCCCC(=O)Nc1ccc(cc1)-c1nc(NC2Cc3ccccc3C2)c2ccccc2n1 InChI=1S/C29H31N5O/c30-17-7-1-2-12-27(35)31-23-15-13-20(14-16-23)28-33-26-11-6-5-10-25(26)29(34-28)32-24-18-21-8-3-4-9-22(21)19-24/h3-6,8-11,13-16,24H,1-2,7,12,17-19,30H2,(H,31,35)(H,32,33,34) DETOMRKEHILFFF-UHFFFAOYSA-N 313448 US10167270, Example 147 Lysosomal acid glucosylceramidase Homo sapiens 7.50 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313448&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124172253 383540348 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605321 CN(CCOc1ccc(cc1)C#N)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H19N5O/c1-28(13-14-29-19-10-8-17(15-24)9-11-19)23-20-6-2-3-7-21(20)26-22(27-23)18-5-4-12-25-16-18/h2-12,16H,13-14H2,1H3 WMJVRRBCOCUEJC-UHFFFAOYSA-N 313449 US10167270, Example 151 Lysosomal acid glucosylceramidase Homo sapiens 7080 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313449&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168433 383540349 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605322 O=C(CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)NCCOCCOCCOCCOCCC(=O)NCCCCCC(=O)Nc1ccc(cc1)-c1nc(NC2Cc3ccccc3C2)c2ccccc2n1 InChI=1S/C50H66N8O8S/c59-44(15-8-7-14-43-47-42(34-67-43)56-50(62)57-47)52-23-25-64-27-29-66-31-30-65-28-26-63-24-21-45(60)51-22-9-1-2-16-46(61)53-38-19-17-35(18-20-38)48-55-41-13-6-5-12-40(41)49(58-48)54-39-32-36-10-3-4-11-37(36)33-39/h3-6,10-13,17-20,39,42-43,47H,1-2,7-9,14-16,21-34H2,(H,51,60)(H,52,59)(H,53,61)(H,54,55,58)(H2,56,57,62)/t42-,43-,47-/m0/s1 DWQWGNJXTLLOMX-DPPJWZTGSA-N 313450 US10167270, Example 156 Lysosomal acid glucosylceramidase Homo sapiens 1.95 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313450&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124172505 383540350 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605323 CN(C)c1ccc2c(-c3ccc(cc3C(O)=O)C(=O)NCCCCCC(=O)Nc3ccc(cc3)-c3nc(NC4Cc5ccccc5C4)c4ccccc4n3)c3ccc(cc3oc2c1)=[N+](C)C InChI=1S/C54H51N7O5/c1-60(2)39-22-25-43-47(31-39)66-48-32-40(61(3)4)23-26-44(48)50(43)41-24-19-36(30-45(41)54(64)65)53(63)55-27-11-5-6-16-49(62)56-37-20-17-33(18-21-37)51-58-46-15-10-9-14-42(46)52(59-51)57-38-28-34-12-7-8-13-35(34)29-38/h7-10,12-15,17-26,30-32,38H,5-6,11,16,27-29H2,1-4H3,(H3-,55,56,57,58,59,62,63,64,65)/p+1 AJZGSZRYXGRUPM-UHFFFAOYSA-O 313451 US10167270, Example 158 Lysosomal acid glucosylceramidase Homo sapiens 79 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313451&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124172278 383540351 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605324 CN(C)c1ccc2c(-c3ccc(cc3C(O)=O)C(=O)NCCOCCOCC(=O)Nc3ccc(cc3)-c3nc(NC4Cc5ccccc5C4)c4ccccc4n3)c3ccc(cc3oc2c1)=[N+](C)C InChI=1S/C54H51N7O7/c1-60(2)39-18-21-43-47(30-39)68-48-31-40(61(3)4)19-22-44(48)50(43)41-20-15-36(29-45(41)54(64)65)53(63)55-23-24-66-25-26-67-32-49(62)56-37-16-13-33(14-17-37)51-58-46-12-8-7-11-42(46)52(59-51)57-38-27-34-9-5-6-10-35(34)28-38/h5-22,29-31,38H,23-28,32H2,1-4H3,(H3-,55,56,57,58,59,62,63,64,65)/p+1 QEEZULWECYGXBL-UHFFFAOYSA-O 313452 US10167270, Example 159 Lysosomal acid glucosylceramidase Homo sapiens 126 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313452&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124172522 383540352 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 605325 CN(C)c1ccc2c(-c3ccc(cc3OC=O)C(=O)NCCOCCOCCOCCOCCC(=O)NCCCCCC(=O)Nc3ccc(cc3)-c3nc(NC4Cc5ccccc5C4)c4ccccc4n3)c3ccc(cc3oc2c1)=[N+](C)C InChI=1S/C65H72N8O10/c1-72(2)50-22-25-54-58(41-50)83-59-42-51(73(3)4)23-26-55(59)62(54)53-24-19-47(40-57(53)82-43-74)65(77)67-29-31-79-33-35-81-37-36-80-34-32-78-30-27-60(75)66-28-11-5-6-16-61(76)68-48-20-17-44(18-21-48)63-70-56-15-10-9-14-52(56)64(71-63)69-49-38-45-12-7-8-13-46(45)39-49/h7-10,12-15,17-26,40-43,49H,5-6,11,16,27-39H2,1-4H3,(H3-,66,67,68,69,70,71,75,76,77)/p+1 VIPLIVNKNZODIT-UHFFFAOYSA-O 313453 US10167270, Example 160 Lysosomal acid glucosylceramidase Homo sapiens 7.1 US Patent 10.7270/Q2862JH8 aid1796432 US10167270 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313453&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 138106771 383540353 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729212 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C18H24F9N3O5S/c19-15(20,16(21,22)17(23,24)18(25,26)27)4-3-9(31)28-5-1-2-6-29-14(36)30-8-7-35-13(30)12(34)11(33)10(8)32/h8,10-13,32-34H,1-7H2,(H,28,31)(H,29,36)/t8-,10-,11+,12-,13+/m1/s1 MDCKIUURCNVTTJ-ZMHPAJMFSA-N 50236278 CHEMBL4077472 Lysosomal acid glucosylceramidase Homo sapiens 35000 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236278&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137651681 384991903 CHEMBL4077472 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729213 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCCCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C25H34F13N3O5S/c26-20(27,21(28,29)22(30,31)23(32,33)24(34,35)25(36,37)38)9-8-14(42)39-10-6-4-2-1-3-5-7-11-40-19(47)41-13-12-46-18(41)17(45)16(44)15(13)43/h13,15-18,43-45H,1-12H2,(H,39,42)(H,40,47)/t13-,15-,16+,17-,18+/m1/s1 YJLFXJUZBBBSCB-LHKMKVQPSA-N 50236279 CHEMBL4093241 Lysosomal acid glucosylceramidase Homo sapiens 4100 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236279&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137654457 384991904 CHEMBL4093241 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729215 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C18H24F9N3O5S/c19-15(20,16(21,22)17(23,24)18(25,26)27)4-3-9(31)28-5-1-2-6-29-14(36)30-8-7-35-13(30)12(34)11(33)10(8)32/h8,10-13,32-34H,1-7H2,(H,28,31)(H,29,36)/t8-,10-,11+,12-,13+/m1/s1 MDCKIUURCNVTTJ-ZMHPAJMFSA-N 50236278 CHEMBL4077472 Lysosomal acid glucosylceramidase Homo sapiens 20800 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236278&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137651681 384991903 CHEMBL4077472 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729218 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCCCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C23H34F9N3O5S/c24-20(25,21(26,27)22(28,29)23(30,31)32)9-8-14(36)33-10-6-4-2-1-3-5-7-11-34-19(41)35-13-12-40-18(35)17(39)16(38)15(13)37/h13,15-18,37-39H,1-12H2,(H,33,36)(H,34,41)/t13-,15-,16+,17-,18+/m1/s1 ZKJVYFGMTHOOKX-LHKMKVQPSA-N 50236281 CHEMBL4076141 Lysosomal acid glucosylceramidase Homo sapiens 9300 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236281&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137649273 384991906 CHEMBL4076141 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729220 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C20H24F13N3O5S/c21-15(22,16(23,24)17(25,26)18(27,28)19(29,30)20(31,32)33)4-3-9(37)34-5-1-2-6-35-14(42)36-8-7-41-13(36)12(40)11(39)10(8)38/h8,10-13,38-40H,1-7H2,(H,34,37)(H,35,42)/t8-,10-,11+,12-,13+/m1/s1 PZSBTAXVTQZJQR-ZMHPAJMFSA-N 50236280 CHEMBL4100971 Lysosomal acid glucosylceramidase Homo sapiens 1400 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236280&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137659840 384991905 CHEMBL4100971 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729221 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCCCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C23H34F9N3O5S/c24-20(25,21(26,27)22(28,29)23(30,31)32)9-8-14(36)33-10-6-4-2-1-3-5-7-11-34-19(41)35-13-12-40-18(35)17(39)16(38)15(13)37/h13,15-18,37-39H,1-12H2,(H,33,36)(H,34,41)/t13-,15-,16+,17-,18+/m1/s1 ZKJVYFGMTHOOKX-LHKMKVQPSA-N 50236281 CHEMBL4076141 Lysosomal acid glucosylceramidase Homo sapiens 8200 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236281&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137649273 384991906 CHEMBL4076141 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729224 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCCCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C25H34F13N3O5S/c26-20(27,21(28,29)22(30,31)23(32,33)24(34,35)25(36,37)38)9-8-14(42)39-10-6-4-2-1-3-5-7-11-40-19(47)41-13-12-46-18(41)17(45)16(44)15(13)43/h13,15-18,43-45H,1-12H2,(H,39,42)(H,40,47)/t13-,15-,16+,17-,18+/m1/s1 YJLFXJUZBBBSCB-LHKMKVQPSA-N 50236279 CHEMBL4093241 Lysosomal acid glucosylceramidase Homo sapiens 7200 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236279&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137654457 384991904 CHEMBL4093241 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729225 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C18H24F9N3O5S/c19-15(20,16(21,22)17(23,24)18(25,26)27)4-3-9(31)28-5-1-2-6-29-14(36)30-8-7-35-13(30)12(34)11(33)10(8)32/h8,10-13,32-34H,1-7H2,(H,28,31)(H,29,36)/t8-,10-,11+,12-,13+/m1/s1 MDCKIUURCNVTTJ-ZMHPAJMFSA-N 50236278 CHEMBL4077472 Lysosomal acid glucosylceramidase Homo sapiens 300 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236278&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137651681 384991903 CHEMBL4077472 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729228 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCCCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C25H34F13N3O5S/c26-20(27,21(28,29)22(30,31)23(32,33)24(34,35)25(36,37)38)9-8-14(42)39-10-6-4-2-1-3-5-7-11-40-19(47)41-13-12-46-18(41)17(45)16(44)15(13)43/h13,15-18,43-45H,1-12H2,(H,39,42)(H,40,47)/t13-,15-,16+,17-,18+/m1/s1 YJLFXJUZBBBSCB-LHKMKVQPSA-N 50236279 CHEMBL4093241 Lysosomal acid glucosylceramidase Homo sapiens 32600 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236279&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137654457 384991904 CHEMBL4093241 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729230 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCCCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C23H34F9N3O5S/c24-20(25,21(26,27)22(28,29)23(30,31)32)9-8-14(36)33-10-6-4-2-1-3-5-7-11-34-19(41)35-13-12-40-18(35)17(39)16(38)15(13)37/h13,15-18,37-39H,1-12H2,(H,33,36)(H,34,41)/t13-,15-,16+,17-,18+/m1/s1 ZKJVYFGMTHOOKX-LHKMKVQPSA-N 50236281 CHEMBL4076141 Lysosomal acid glucosylceramidase Homo sapiens 80000 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236281&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137649273 384991906 CHEMBL4076141 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729234 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C20H24F13N3O5S/c21-15(22,16(23,24)17(25,26)18(27,28)19(29,30)20(31,32)33)4-3-9(37)34-5-1-2-6-35-14(42)36-8-7-41-13(36)12(40)11(39)10(8)38/h8,10-13,38-40H,1-7H2,(H,34,37)(H,35,42)/t8-,10-,11+,12-,13+/m1/s1 PZSBTAXVTQZJQR-ZMHPAJMFSA-N 50236280 CHEMBL4100971 Lysosomal acid glucosylceramidase Homo sapiens 90 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236280&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137659840 384991905 CHEMBL4100971 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729235 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCCCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C23H34F9N3O5S/c24-20(25,21(26,27)22(28,29)23(30,31)32)9-8-14(36)33-10-6-4-2-1-3-5-7-11-34-19(41)35-13-12-40-18(35)17(39)16(38)15(13)37/h13,15-18,37-39H,1-12H2,(H,33,36)(H,34,41)/t13-,15-,16+,17-,18+/m1/s1 ZKJVYFGMTHOOKX-LHKMKVQPSA-N 50236281 CHEMBL4076141 Lysosomal acid glucosylceramidase Homo sapiens 900 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236281&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137649273 384991906 CHEMBL4076141 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729238 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCCCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C25H34F13N3O5S/c26-20(27,21(28,29)22(30,31)23(32,33)24(34,35)25(36,37)38)9-8-14(42)39-10-6-4-2-1-3-5-7-11-40-19(47)41-13-12-46-18(41)17(45)16(44)15(13)43/h13,15-18,43-45H,1-12H2,(H,39,42)(H,40,47)/t13-,15-,16+,17-,18+/m1/s1 YJLFXJUZBBBSCB-LHKMKVQPSA-N 50236279 CHEMBL4093241 Lysosomal acid glucosylceramidase Homo sapiens 600 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236279&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137654457 384991904 CHEMBL4093241 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729239 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C18H24F9N3O5S/c19-15(20,16(21,22)17(23,24)18(25,26)27)4-3-9(31)28-5-1-2-6-29-14(36)30-8-7-35-13(30)12(34)11(33)10(8)32/h8,10-13,32-34H,1-7H2,(H,28,31)(H,29,36)/t8-,10-,11+,12-,13+/m1/s1 MDCKIUURCNVTTJ-ZMHPAJMFSA-N 50236278 CHEMBL4077472 Lysosomal acid glucosylceramidase Homo sapiens 4500 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236278&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137651681 384991903 CHEMBL4077472 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729241 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C20H24F13N3O5S/c21-15(22,16(23,24)17(25,26)18(27,28)19(29,30)20(31,32)33)4-3-9(37)34-5-1-2-6-35-14(42)36-8-7-41-13(36)12(40)11(39)10(8)38/h8,10-13,38-40H,1-7H2,(H,34,37)(H,35,42)/t8-,10-,11+,12-,13+/m1/s1 PZSBTAXVTQZJQR-ZMHPAJMFSA-N 50236280 CHEMBL4100971 Lysosomal acid glucosylceramidase Homo sapiens 90000 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236280&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137659840 384991905 CHEMBL4100971 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50729245 O[C@@H]1[C@H]2CO[C@@H]([C@H](O)[C@H]1O)N2C(=S)NCCCCNC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F InChI=1S/C20H24F13N3O5S/c21-15(22,16(23,24)17(25,26)18(27,28)19(29,30)20(31,32)33)4-3-9(37)34-5-1-2-6-35-14(42)36-8-7-41-13(36)12(40)11(39)10(8)38/h8,10-13,38-40H,1-7H2,(H,34,37)(H,35,42)/t8-,10-,11+,12-,13+/m1/s1 PZSBTAXVTQZJQR-ZMHPAJMFSA-N 50236280 CHEMBL4100971 Lysosomal acid glucosylceramidase Homo sapiens 11900 ChEMBL 10.1021/acs.jmedchem.6b01550 10.7270/Q2K939S5 28171725 García-Moreno, MI; de la Mata, M; Sánchez-Fernández, EM; Benito, JM; Díaz-Quintana, A; Fustero, S; Nanba, E; Higaki, K; Sánchez-Alcázar, JA; García Fernández, JM; Ortiz Mellet, C University of Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50236280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50236280&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137659840 384991905 CHEMBL4100971 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693610 COC[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C9H17NO3/c1-13-5-6-8(12)7(11)4-10-9(6)2-3-9/h6-8,10-12H,2-5H2,1H3/t6-,7-,8-/m1/s1 UREIBDHTHIOCAG-BWZBUEFSSA-N 285824 (6R,7R,8R)-8-(methoxymethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 6::US9796680, Example 6 Lysosomal acid glucosylceramidase Homo sapiens 7.50 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285824&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197605 378169461 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693611 CO[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C8H15NO3/c1-12-7-6(11)5(10)4-9-8(7)2-3-8/h5-7,9-11H,2-4H2,1H3/t5-,6+,7-/m1/s1 TYUVSEJCCYQRRS-DSYKOEDSSA-N 285825 (6R,7S,8S)-8-methoxy-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 7::US9796680, Example 7 Lysosomal acid glucosylceramidase Homo sapiens 32.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285825&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197644 378169462 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693612 O[C@@H]1CNC2(CC2)[C@H](C#N)[C@H]1O InChI=1S/C8H12N2O2/c9-3-5-7(12)6(11)4-10-8(5)1-2-8/h5-7,10-12H,1-2,4H2/t5-,6-,7-/m1/s1 WOKVFVFSTFFEDJ-FSDSQADBSA-N 285826 (6R,7R,8R)-6,7-dihydroxy-4-azaspiro[2.5]octane-8-carbonitrile::US10081601, Example 8::US9796680, Example 8 Lysosomal acid glucosylceramidase Homo sapiens 75.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285826&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197607 378169463 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693613 O[C@@H]1CNC2(CC2)[C@@H]([C@H]1O)C(O)=O InChI=1S/C8H13NO4/c10-4-3-9-8(1-2-8)5(6(4)11)7(12)13/h4-6,9-11H,1-3H2,(H,12,13)/t4-,5+,6+/m1/s1 JOBWNRYDTOZDMC-SRQIZXRXSA-N 285827 (6R,7R,8S)-6,7-dihydroxy-4-azaspiro[2.5]octane-8-carboxylic acid::US10081601, Example 9::US9796680, Example 9 Lysosomal acid glucosylceramidase Homo sapiens 507 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285827&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197645 378169464 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693614 CNC(=O)[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C9H16N2O3/c1-10-8(14)6-7(13)5(12)4-11-9(6)2-3-9/h5-7,11-13H,2-4H2,1H3,(H,10,14)/t5-,6+,7+/m1/s1 JIXJUDKLYVZZEK-VQVTYTSYSA-N 285828 (6R,7R,8S)-6,7-dihydroxy-N-methyl-4-azaspiro[2.5]octane-8-carboxamide::US10081601, Example 10::US9796680, Example 10 Lysosomal acid glucosylceramidase Homo sapiens 264 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285828&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197617 378169465 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693615 O[C@@H]1CNC2(CC2)[C@@H]([C@H]1O)C(=O)NC1CC1 InChI=1S/C11H18N2O3/c14-7-5-12-11(3-4-11)8(9(7)15)10(16)13-6-1-2-6/h6-9,12,14-15H,1-5H2,(H,13,16)/t7-,8+,9+/m1/s1 OZMBWHOGRHGGHS-VGMNWLOBSA-N 285829 (6R,7R,8S)—N-cyclopropyl-6,7-dihydroxy-4-azaspiro[2.5]octane-8-carboxamide::US10081601, Example 11::US9796680, Example 11 Lysosomal acid glucosylceramidase Homo sapiens 462 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285829&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197783 378169466 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693616 CC[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C9H17NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h6-8,10-12H,2-5H2,1H3/t6-,7-,8-/m1/s1 LYPUWEGFMHAGTQ-BWZBUEFSSA-N 285830 (6R,7R,8S)-8-ethyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 12::US9796680, Example 12 Lysosomal acid glucosylceramidase Homo sapiens 6.30 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285830&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197652 378169467 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693617 CCC[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C10H19NO2/c1-2-3-7-9(13)8(12)6-11-10(7)4-5-10/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1 FDKSMHXBSQZVST-IWSPIJDZSA-N 285831 (6R,7R,8S)-8-propyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 13::US9796680, Example 13 Lysosomal acid glucosylceramidase Homo sapiens 15.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285831&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197720 378169468 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693618 O[C@@H]1CNC2(CC2)[C@H](CCF)[C@H]1O InChI=1S/C9H16FNO2/c10-4-1-6-8(13)7(12)5-11-9(6)2-3-9/h6-8,11-13H,1-5H2/t6-,7-,8-/m1/s1 MVUMUMOZSPIRQJ-BWZBUEFSSA-N 285832 (6R,7R,8S)-8-(2-fluoroethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 14::US9796680, Example 14 Lysosomal acid glucosylceramidase Homo sapiens 27.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285832&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197680 378169469 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693619 CC(F)C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C10H18FNO2/c1-6(11)4-7-9(14)8(13)5-12-10(7)2-3-10/h6-9,12-14H,2-5H2,1H3/t6?,7-,8-,9-/m1/s1 DLAUAABNRCDMDT-FUZJYRNYSA-N 350905 (6R,7R,8S)-8-(2,2-difluoroethyl)-4-azaspiro[2.5]octane-6,7-diol::US9796680, Example 15 Lysosomal acid glucosylceramidase Homo sapiens 56.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=350905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=350905&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 126501551 386052637 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693620 O[C@@H]1CNC2(CC2)[C@H](C=C)[C@H]1O InChI=1S/C9H15NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h2,6-8,10-12H,1,3-5H2/t6-,7-,8-/m1/s1 JNIYJHDOBMNALK-BWZBUEFSSA-N 285834 (6R,7R,8S)-8-vinyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 16::US9796680, Example 16 Lysosomal acid glucosylceramidase Homo sapiens 6.80 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285834&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197774 378169471 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693621 O[C@@H]1CNC2(CC2)[C@H](C=C)[C@H]1O InChI=1S/C9H15NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h2,6-8,10-12H,1,3-5H2/t6-,7-,8-/m1/s1 JNIYJHDOBMNALK-BWZBUEFSSA-N 285834 (6R,7R,8S)-8-vinyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 16::US9796680, Example 16 Lysosomal acid glucosylceramidase Homo sapiens 7.60 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285834&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197774 378169471 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693622 O[C@@H]1CNC2(CC2)[C@H](\C=C/F)[C@H]1O InChI=1S/C9H14FNO2/c10-4-1-6-8(13)7(12)5-11-9(6)2-3-9/h1,4,6-8,11-13H,2-3,5H2/b4-1-/t6-,7-,8-/m1/s1 OMLFGBKTKHVSQF-XZFIUINESA-N 285835 (6R,7R,8S)-8-((Z)-2-fluorovinyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 17::US9796680, Example 17 Lysosomal acid glucosylceramidase Homo sapiens 36.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285835&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197675 378169472 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693623 O[C@@H]1CNC2(CC2)[C@H](\C=C\F)[C@H]1O InChI=1S/C9H14FNO2/c10-4-1-6-8(13)7(12)5-11-9(6)2-3-9/h1,4,6-8,11-13H,2-3,5H2/b4-1+/t6-,7-,8-/m1/s1 OMLFGBKTKHVSQF-HIDXBHDTSA-N 285836 (6R,7R,8S)-8-((E)-2-fluorovinyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 18::US9796680, Example 18 Lysosomal acid glucosylceramidase Homo sapiens 20.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285836&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197668 378169473 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693624 O[C@@H]1CNC2(CC2)[C@H](C=C(F)F)[C@H]1O InChI=1S/C9H13F2NO2/c10-7(11)3-5-8(14)6(13)4-12-9(5)1-2-9/h3,5-6,8,12-14H,1-2,4H2/t5-,6-,8-/m1/s1 GYYKXPIHCCASMM-ATRFCDNQSA-N 285837 (6R,7R,8S)-8-(2,2-difluorovinyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 19::US9796680, Example 19 Lysosomal acid glucosylceramidase Homo sapiens 75.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285837&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197628 378169474 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693625 O[C@@H]1CNC2(CC2)[C@H](C#C)[C@H]1O InChI=1S/C9H13NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h1,6-8,10-12H,3-5H2/t6-,7-,8-/m1/s1 WZAZBGHAPRDLFW-BWZBUEFSSA-N 285838 (6R,7R,8S)-8-ethynyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 20::US9796680, Example 20 Lysosomal acid glucosylceramidase Homo sapiens 13.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285838&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197640 378169475 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693626 O[C@@H]1CNC2(CC2)[C@H](C#C)[C@H]1O InChI=1S/C9H13NO2/c1-2-6-8(12)7(11)5-10-9(6)3-4-9/h1,6-8,10-12H,3-5H2/t6-,7-,8-/m1/s1 WZAZBGHAPRDLFW-BWZBUEFSSA-N 285838 (6R,7R,8S)-8-ethynyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 20::US9796680, Example 20 Lysosomal acid glucosylceramidase Homo sapiens 7.90 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285838&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197640 378169475 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693627 CC#C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C10H15NO2/c1-2-3-7-9(13)8(12)6-11-10(7)4-5-10/h7-9,11-13H,4-6H2,1H3/t7-,8-,9-/m1/s1 CFLYIQUIFBLZQN-IWSPIJDZSA-N 285839 (6R,7R,8S)-8-(prop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 21::US9796680, Example 21 Lysosomal acid glucosylceramidase Homo sapiens 9.70 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285839&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197611 378169476 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693628 CC#C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C10H15NO2/c1-2-3-7-9(13)8(12)6-11-10(7)4-5-10/h7-9,11-13H,4-6H2,1H3/t7-,8-,9-/m1/s1 CFLYIQUIFBLZQN-IWSPIJDZSA-N 285839 (6R,7R,8S)-8-(prop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 21::US9796680, Example 21 Lysosomal acid glucosylceramidase Homo sapiens 6.70 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285839&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197611 378169476 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693629 CCC#C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C11H17NO2/c1-2-3-4-8-10(14)9(13)7-12-11(8)5-6-11/h8-10,12-14H,2,5-7H2,1H3/t8-,9-,10-/m1/s1 RUUGSGCVICOVQG-OPRDCNLKSA-N 285840 (6R,7R,8S)-8-(but-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 22::US9796680, Example 22 Lysosomal acid glucosylceramidase Homo sapiens 2.40 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285840&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118199409 378169477 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693630 CCCC#C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C12H19NO2/c1-2-3-4-5-9-11(15)10(14)8-13-12(9)6-7-12/h9-11,13-15H,2-3,6-8H2,1H3/t9-,10-,11-/m1/s1 USECWGHCBFNPNA-GMTAPVOTSA-N 285841 (6R,7R,8S)-8-(pent-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 23::US9796680, Example 23 Lysosomal acid glucosylceramidase Homo sapiens 6.70 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285841&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197648 378169478 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693631 OCC#C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C10H15NO3/c12-5-1-2-7-9(14)8(13)6-11-10(7)3-4-10/h7-9,11-14H,3-6H2/t7-,8-,9-/m1/s1 JGTGAWSDCHTBRU-IWSPIJDZSA-N 285842 (6R,7R,8S)-8-(3-hydroxyprop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 24::US9796680, Example 24 Lysosomal acid glucosylceramidase Homo sapiens 17.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285842&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197658 378169479 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693632 O[C@@H]1CNC2(CC2)[C@H](C#CCF)[C@H]1O InChI=1S/C10H14FNO2/c11-5-1-2-7-9(14)8(13)6-12-10(7)3-4-10/h7-9,12-14H,3-6H2/t7-,8-,9-/m1/s1 VGBGTBVAHJMEJG-IWSPIJDZSA-N 285843 (6R,7R,8S)-8-(3-fluoroprop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 25::US9796680, Example 25 Lysosomal acid glucosylceramidase Homo sapiens 16.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285843&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197625 378169480 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693633 O[C@@H]1CNC2(CC2)[C@H](C#CCF)[C@H]1O InChI=1S/C10H14FNO2/c11-5-1-2-7-9(14)8(13)6-12-10(7)3-4-10/h7-9,12-14H,3-6H2/t7-,8-,9-/m1/s1 VGBGTBVAHJMEJG-IWSPIJDZSA-N 285843 (6R,7R,8S)-8-(3-fluoroprop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 25::US9796680, Example 25 Lysosomal acid glucosylceramidase Homo sapiens 15.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285843&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197625 378169480 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693634 O[C@@H]1CNC2(CC2)[C@H](C#CC(F)F)[C@H]1O InChI=1S/C10H13F2NO2/c11-8(12)2-1-6-9(15)7(14)5-13-10(6)3-4-10/h6-9,13-15H,3-5H2/t6-,7-,9-/m1/s1 ZTOJJKUWDSLXKW-ZXFLCMHBSA-N 285844 (6R,7R,8S)-8-(3,3-difluoroprop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 26::US9796680, Example 26 Lysosomal acid glucosylceramidase Homo sapiens 22.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285844&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197603 378169481 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693635 O[C@@H]1CNC2(CC2)[C@H](C#CC(F)F)[C@H]1O InChI=1S/C10H13F2NO2/c11-8(12)2-1-6-9(15)7(14)5-13-10(6)3-4-10/h6-9,13-15H,3-5H2/t6-,7-,9-/m1/s1 ZTOJJKUWDSLXKW-ZXFLCMHBSA-N 285844 (6R,7R,8S)-8-(3,3-difluoroprop-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 26::US9796680, Example 26 Lysosomal acid glucosylceramidase Homo sapiens 17.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285844&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197603 378169481 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693636 O[C@@H]1CNC2(CC2)[C@H](C#CCCF)[C@H]1O InChI=1S/C11H16FNO2/c12-6-2-1-3-8-10(15)9(14)7-13-11(8)4-5-11/h8-10,13-15H,2,4-7H2/t8-,9-,10-/m1/s1 XHIYEWJIECDGPW-OPRDCNLKSA-N 285845 (6R,7R,8S)-8-(4-fluorobut-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 27::US9796680, Example 27 Lysosomal acid glucosylceramidase Homo sapiens 2.50 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285845&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118199314 378169482 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693637 O[C@@H]1CNC2(CC2)[C@H](C#CCC(F)F)[C@H]1O InChI=1S/C11H15F2NO2/c12-9(13)3-1-2-7-10(16)8(15)6-14-11(7)4-5-11/h7-10,14-16H,3-6H2/t7-,8-,10-/m1/s1 NCVMRSPXAUZSMD-NQMVMOMDSA-N 285846 (6R,7R,8S)-8-(4,4-difluorobut-1-yn-1-yl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 28::US9796680, Example 28 Lysosomal acid glucosylceramidase Homo sapiens 11.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285846&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118199315 378169483 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50797504 CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H]1CO InChI=1S/C24H37N3O6S/c1-27(2)19-11-7-10-17-16(19)9-8-12-20(17)34(32,33)26-14-6-4-3-5-13-25-21-18(15-28)22(29)24(31)23(21)30/h7-12,18,21-26,28-31H,3-6,13-15H2,1-2H3/t18-,21+,22-,23-,24-/m0/s1 UQDXIILZCYJPNV-GXWFBMCDSA-N 50254109 CHEMBL4069909 Lysosomal acid glucosylceramidase Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2017.05.086 10.7270/Q29889D9 28600215 Schalli, M; Weber, P; Tysoe, C; Pabst, BM; Thonhofer, M; Paschke, E; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG Graz University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254109&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search N0N 6TBG 137640259 401958023 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50797508 CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCCN(C)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H]1CO InChI=1S/C25H39N3O6S/c1-27(2)20-12-8-11-18-17(20)10-9-13-21(18)35(33,34)26-14-6-4-5-7-15-28(3)22-19(16-29)23(30)25(32)24(22)31/h8-13,19,22-26,29-32H,4-7,14-16H2,1-3H3/t19-,22+,23-,24-,25-/m0/s1 ZZSYNRUICILULX-OQYVTVKQSA-N 50254115 CHEMBL4080589 Lysosomal acid glucosylceramidase Homo sapiens 1.000000 ChEMBL 10.1016/j.bmcl.2017.05.086 10.7270/Q29889D9 28600215 Schalli, M; Weber, P; Tysoe, C; Pabst, BM; Thonhofer, M; Paschke, E; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG Graz University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254115&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137645711 401958024 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50797509 CCCCCCCCN[C@@H]1C=C(CO)[C@H](O)[C@H](O)[C@H]1O InChI=1S/C15H29NO4/c1-2-3-4-5-6-7-8-16-12-9-11(10-17)13(18)15(20)14(12)19/h9,12-20H,2-8,10H2,1H3/t12-,13+,14+,15+/m1/s1 UPZUHYMBTUUPML-QPSCCSFWSA-N 50358321 CHEMBL1922579::CHEMBL1922581 Lysosomal acid glucosylceramidase Homo sapiens 83000 ChEMBL 10.1016/j.bmcl.2017.05.086 10.7270/Q29889D9 28600215 Schalli, M; Weber, P; Tysoe, C; Pabst, BM; Thonhofer, M; Paschke, E; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG Graz University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358321&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search N8V 3WEZ,6TBI 10039700 136962345 CHEMBL1922581CHEMBL1922579 ZINC14175219 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50797514 OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H]1NCCCC#N InChI=1S/C10H18N2O4/c11-3-1-2-4-12-7-6(5-13)8(14)10(16)9(7)15/h6-10,12-16H,1-2,4-5H2/t6-,7+,8-,9-,10-/m0/s1 OYWGNGNFRPMACV-SVSWQMSJSA-N 50254117 CHEMBL4061246 Lysosomal acid glucosylceramidase Homo sapiens 10300 ChEMBL 10.1016/j.bmcl.2017.05.086 10.7270/Q29889D9 28600215 Schalli, M; Weber, P; Tysoe, C; Pabst, BM; Thonhofer, M; Paschke, E; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG Graz University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254117&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137634997 401958026 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50797517 NCCCCCCN[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H]1CO InChI=1S/C12H26N2O4/c13-5-3-1-2-4-6-14-9-8(7-15)10(16)12(18)11(9)17/h8-12,14-18H,1-7,13H2/t8-,9+,10-,11-,12-/m0/s1 LKCGCOWKCBGIJU-OSUNSFLBSA-N 50254118 CHEMBL4090899 Lysosomal acid glucosylceramidase Homo sapiens 54200 ChEMBL 10.1016/j.bmcl.2017.05.086 10.7270/Q29889D9 28600215 Schalli, M; Weber, P; Tysoe, C; Pabst, BM; Thonhofer, M; Paschke, E; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG Graz University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254118&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137644530 401958027 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50797520 OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H]1N1CCCC1 InChI=1S/C10H19NO4/c12-5-6-7(11-3-1-2-4-11)9(14)10(15)8(6)13/h6-10,12-15H,1-5H2/t6-,7+,8-,9-,10-/m0/s1 RSZNDZIEBMZFLI-SVSWQMSJSA-N 50254119 CHEMBL4098625 Lysosomal acid glucosylceramidase Homo sapiens 123000 ChEMBL 10.1016/j.bmcl.2017.05.086 10.7270/Q29889D9 28600215 Schalli, M; Weber, P; Tysoe, C; Pabst, BM; Thonhofer, M; Paschke, E; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG Graz University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254119&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137661141 401958028 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50797522 OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H]1NCCCCCC#N InChI=1S/C12H22N2O4/c13-5-3-1-2-4-6-14-9-8(7-15)10(16)12(18)11(9)17/h8-12,14-18H,1-4,6-7H2/t8-,9+,10-,11-,12-/m0/s1 DLCHVBWCGPOWMH-OSUNSFLBSA-N 50254116 CHEMBL4083115 Lysosomal acid glucosylceramidase Homo sapiens 10700 ChEMBL 10.1016/j.bmcl.2017.05.086 10.7270/Q29889D9 28600215 Schalli, M; Weber, P; Tysoe, C; Pabst, BM; Thonhofer, M; Paschke, E; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG Graz University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254116&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 137647938 401958025 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693597 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 8.20 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693598 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 1.70 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693599 CCCC1(CCC)NC[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C12H25NO3/c1-3-5-12(6-4-2)9(8-14)11(16)10(15)7-13-12/h9-11,13-16H,3-8H2,1-2H3/t9-,10-,11-/m1/s1 GZJQITPDATVFSD-GMTAPVOTSA-N 285817 US10081601, Example 1.2::US9796680, Example Table2.2 Lysosomal acid glucosylceramidase Homo sapiens 1400 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285817&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197601 378169454 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693600 CC1(C)NC[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C8H17NO3/c1-8(2)5(4-10)7(12)6(11)3-9-8/h5-7,9-12H,3-4H2,1-2H3/t5-,6-,7-/m1/s1 VQHFRRBJUIUVOE-FSDSQADBSA-N 285818 US10081601, Example 1.3::US9796680, Example Table2.3 Lysosomal acid glucosylceramidase Homo sapiens 222 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285818&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197651 378169455 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693601 C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C8H15NO2/c1-5-7(11)6(10)4-9-8(5)2-3-8/h5-7,9-11H,2-4H2,1H3/t5-,6-,7-/m1/s1 SNBKQXWAMBQGSA-FSDSQADBSA-N 285819 (6R,7R,8S)-8-methyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 1::US9796680, Example 1 Lysosomal acid glucosylceramidase Homo sapiens 3.70 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285819&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197630 378169456 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693602 C[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C8H15NO2/c1-5-7(11)6(10)4-9-8(5)2-3-8/h5-7,9-11H,2-4H2,1H3/t5-,6-,7-/m1/s1 SNBKQXWAMBQGSA-FSDSQADBSA-N 285819 (6R,7R,8S)-8-methyl-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 1::US9796680, Example 1 Lysosomal acid glucosylceramidase Homo sapiens 2.60 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285819&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197630 378169456 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693603 OC[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C8H15NO3/c10-4-5-7(12)6(11)3-9-8(5)1-2-8/h5-7,9-12H,1-4H2/t5-,6-,7-/m1/s1 UVWFVBWKBBONDJ-FSDSQADBSA-N 285820 (6R,7R,8R)-8-(hydroxymethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 2::US9796680, Example 2 Lysosomal acid glucosylceramidase Homo sapiens 13.0 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285820&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197685 378169457 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693604 OC[C@@H]1[C@@H](O)[C@H](O)CNC11CC1 InChI=1S/C8H15NO3/c10-4-5-7(12)6(11)3-9-8(5)1-2-8/h5-7,9-12H,1-4H2/t5-,6-,7-/m1/s1 UVWFVBWKBBONDJ-FSDSQADBSA-N 285820 (6R,7R,8R)-8-(hydroxymethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 2::US9796680, Example 2 Lysosomal acid glucosylceramidase Homo sapiens 7.00 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285820&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197685 378169457 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693605 O[C@@H]1CNC2(CC2)[C@H](CF)[C@H]1O InChI=1S/C8H14FNO2/c9-3-5-7(12)6(11)4-10-8(5)1-2-8/h5-7,10-12H,1-4H2/t5-,6-,7-/m1/s1 MFUFEXHORIKDTD-FSDSQADBSA-N 285821 (6R,7R,8S)-8-(fluoromethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 3::US9796680, Example 3 Lysosomal acid glucosylceramidase Homo sapiens 6.20 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285821&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 91810852 378169458 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693606 O[C@@H]1CNC2(CC2)[C@H](CF)[C@H]1O InChI=1S/C8H14FNO2/c9-3-5-7(12)6(11)4-10-8(5)1-2-8/h5-7,10-12H,1-4H2/t5-,6-,7-/m1/s1 MFUFEXHORIKDTD-FSDSQADBSA-N 285821 (6R,7R,8S)-8-(fluoromethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 3::US9796680, Example 3 Lysosomal acid glucosylceramidase Homo sapiens 2.10 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285821&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 91810852 378169458 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693607 O[C@@H]1CNC2(CC2)[C@H](C(F)F)[C@H]1O InChI=1S/C8H13F2NO2/c9-7(10)5-6(13)4(12)3-11-8(5)1-2-8/h4-7,11-13H,1-3H2/t4-,5+,6+/m1/s1 HNWFXDPDLGNHIM-SRQIZXRXSA-N 285822 (6R,7R,8S)-8-(difluoromethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 4::US9796680, Example 4 Lysosomal acid glucosylceramidase Homo sapiens 6.50 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285822&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197634 378169459 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693608 O[C@@H]1CNC2(CC2)[C@H](C(F)F)[C@H]1O InChI=1S/C8H13F2NO2/c9-7(10)5-6(13)4(12)3-11-8(5)1-2-8/h4-7,11-13H,1-3H2/t4-,5+,6+/m1/s1 HNWFXDPDLGNHIM-SRQIZXRXSA-N 285822 (6R,7R,8S)-8-(difluoromethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 4::US9796680, Example 4 Lysosomal acid glucosylceramidase Homo sapiens 8.00 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285822&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197634 378169459 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 693609 O[C@@H]1CNC2(CC2)[C@H](CCl)[C@H]1O InChI=1S/C8H14ClNO2/c9-3-5-7(12)6(11)4-10-8(5)1-2-8/h5-7,10-12H,1-4H2/t5-,6-,7-/m1/s1 PJBIJTLFOHTQLS-FSDSQADBSA-N 285823 (6R,7R,8S)-8-(chloromethyl)-4-azaspiro[2.5]octane-6,7-diol::US10081601, Example 5::US9796680, Example 5 Lysosomal acid glucosylceramidase Homo sapiens 7.40 US Patent 10.7270/Q2SN0C36 aid1797477 US9796680 Kaul, R; McEachern, EJ; Sun, J; Vocadlo, DJ; Zhou, Y; Zhu, Y Alectos Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285823&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118197606 378169460 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 50763411 CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 UQRORFVVSGFNRO-UTINFBMNSA-N 18355 (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol::CHEMBL1029::MIGLUSTAT::N-Butyl-DNJ::US9181184, 5 Lysosomal acid glucosylceramidase Homo sapiens 300000 ChEMBL 10.1021/acs.jmedchem.7b00646 10.7270/Q2SJ1P1C 29112434 D'Alonzo, D; De Fenza, M; Porto, C; Iacono, R; Huebecker, M; Cobucci-Ponzano, B; Priestman, DA; Platt, F; Parenti, G; Moracci, M; Palumbo, G; Guaragna, A Universit£ degli Studi di Napoli Federico II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18355&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NBV 5IEF,2V3D 51634 46518432 50381 CHEMBL1029 DB00419 4841 ZINC03794711 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51116584 COc1ccc2cc(ccc2c1)-c1cn(C[C@H]2NC[C@@H](O)[C@H]2O)nn1 InChI=1S/C18H20N4O3/c1-25-14-5-4-11-6-13(3-2-12(11)7-14)15-9-22(21-20-15)10-16-18(24)17(23)8-19-16/h2-7,9,16-19,23-24H,8,10H2,1H3/t16-,17-,18+/m1/s1 ZOOUMQYUSBXRNQ-KURKYZTESA-N 50456586 CHEMBL4205735 Lysosomal acid glucosylceramidase Homo sapiens 19000 ChEMBL 10.1016/j.ejmech.2017.06.055 10.7270/Q2T43WQR 28692917 Martínez-Bailén, M; Carmona, AT; Moreno-Clavijo, E; Robina, I; Ide, D; Kato, A; Moreno-Vargas, AJ University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456586&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 145977376 433923853 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51116588 O[C@@H]1CN[C@@H](Cn2cc(nn2)-c2ccccc2)[C@@H]1O InChI=1S/C13H16N4O2/c18-12-6-14-11(13(12)19)8-17-7-10(15-16-17)9-4-2-1-3-5-9/h1-5,7,11-14,18-19H,6,8H2/t11-,12+,13-/m0/s1 ALYWSXSJHQVCSB-XQQFMLRXSA-N 50456589 CHEMBL4211283 Lysosomal acid glucosylceramidase Homo sapiens 11000 ChEMBL 10.1016/j.ejmech.2017.06.055 10.7270/Q2T43WQR 28692917 Martínez-Bailén, M; Carmona, AT; Moreno-Clavijo, E; Robina, I; Ide, D; Kato, A; Moreno-Vargas, AJ University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456589&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 145967390 433923856 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51116589 O[C@@H]1CN[C@H](Cn2cc(nn2)-c2ccccc2)[C@@H]1O InChI=1S/C13H16N4O2/c18-12-6-14-11(13(12)19)8-17-7-10(15-16-17)9-4-2-1-3-5-9/h1-5,7,11-14,18-19H,6,8H2/t11-,12-,13+/m1/s1 ALYWSXSJHQVCSB-UPJWGTAASA-N 50456590 CHEMBL4206239 Lysosomal acid glucosylceramidase Homo sapiens 28000 ChEMBL 10.1016/j.ejmech.2017.06.055 10.7270/Q2T43WQR 28692917 Martínez-Bailén, M; Carmona, AT; Moreno-Clavijo, E; Robina, I; Ide, D; Kato, A; Moreno-Vargas, AJ University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456590&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 145978797 433923857 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51116590 COc1ccc(cc1)-c1cn(C[C@H]2NC[C@@H](O)[C@H]2O)nn1 InChI=1S/C14H18N4O3/c1-21-10-4-2-9(3-5-10)11-7-18(17-16-11)8-12-14(20)13(19)6-15-12/h2-5,7,12-15,19-20H,6,8H2,1H3/t12-,13-,14+/m1/s1 ULCQBQQZAQOXJM-MCIONIFRSA-N 50456585 CHEMBL4218664 Lysosomal acid glucosylceramidase Homo sapiens 31000 ChEMBL 10.1016/j.ejmech.2017.06.055 10.7270/Q2T43WQR 28692917 Martínez-Bailén, M; Carmona, AT; Moreno-Clavijo, E; Robina, I; Ide, D; Kato, A; Moreno-Vargas, AJ University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456585&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 145971016 433923852 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51116597 OCc1ccc(cc1)-c1cn(C[C@H]2NC[C@@H](O)[C@H]2O)nn1 InChI=1S/C14H18N4O3/c19-8-9-1-3-10(4-2-9)11-6-18(17-16-11)7-12-14(21)13(20)5-15-12/h1-4,6,12-15,19-21H,5,7-8H2/t12-,13-,14+/m1/s1 UVLCRTIAHMWRGK-MCIONIFRSA-N 50456587 CHEMBL4209809 Lysosomal acid glucosylceramidase Homo sapiens 187000 ChEMBL 10.1016/j.ejmech.2017.06.055 10.7270/Q2T43WQR 28692917 Martínez-Bailén, M; Carmona, AT; Moreno-Clavijo, E; Robina, I; Ide, D; Kato, A; Moreno-Vargas, AJ University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456587&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 145965670 433923854 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51116601 C[Si](C)(C)Cc1cn(C[C@@H]2NC[C@@H](O)[C@H]2O)nn1 InChI=1S/C11H22N4O2Si/c1-18(2,3)7-8-5-15(14-13-8)6-9-11(17)10(16)4-12-9/h5,9-12,16-17H,4,6-7H2,1-3H3/t9-,10+,11-/m0/s1 WFLDAVGPMGGPEF-AXFHLTTASA-N 50456591 CHEMBL4214151 Lysosomal acid glucosylceramidase Homo sapiens 19000 ChEMBL 10.1016/j.ejmech.2017.06.055 10.7270/Q2T43WQR 28692917 Martínez-Bailén, M; Carmona, AT; Moreno-Clavijo, E; Robina, I; Ide, D; Kato, A; Moreno-Vargas, AJ University of Seville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456591&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 145972263 433923858 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853567 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 22.4 US Patent 10.7270/Q24170FP aid1804032 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853568 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 8.70 US Patent 10.7270/Q24170FP aid1804033 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853569 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 16.9 US Patent 10.7270/Q24170FP aid1804034 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853570 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 30.1 US Patent 10.7270/Q24170FP aid1804032 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853571 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 9.90 US Patent 10.7270/Q24170FP aid1804033 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853572 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 18.8 US Patent 10.7270/Q24170FP aid1804034 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853573 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-7-16-13-18(12-15(16)6-1)24-22-19-9-3-4-10-20(19)25-21(26-22)17-8-5-11-23-14-17/h1-11,14,18H,12-13H2,(H,24,25,26) XXCCBJLQMRHXKM-UHFFFAOYSA-N 50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c Lysosomal acid glucosylceramidase Homo sapiens 25.9 US Patent 10.7270/Q24170FP aid1804032 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168025 375977485 CHEMBL3923120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853574 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-7-16-13-18(12-15(16)6-1)24-22-19-9-3-4-10-20(19)25-21(26-22)17-8-5-11-23-14-17/h1-11,14,18H,12-13H2,(H,24,25,26) XXCCBJLQMRHXKM-UHFFFAOYSA-N 50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c Lysosomal acid glucosylceramidase Homo sapiens 8.30 US Patent 10.7270/Q24170FP aid1804033 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168025 375977485 CHEMBL3923120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853575 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-7-16-13-18(12-15(16)6-1)24-22-19-9-3-4-10-20(19)25-21(26-22)17-8-5-11-23-14-17/h1-11,14,18H,12-13H2,(H,24,25,26) XXCCBJLQMRHXKM-UHFFFAOYSA-N 50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c Lysosomal acid glucosylceramidase Homo sapiens 12.7 US Patent 10.7270/Q24170FP aid1804034 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168025 375977485 CHEMBL3923120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853576 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C23H19N3/c1-2-8-16(9-3-1)22-25-21-13-7-6-12-20(21)23(26-22)24-19-14-17-10-4-5-11-18(17)15-19/h1-13,19H,14-15H2,(H,24,25,26) DCLFPHIXBNDNBF-UHFFFAOYSA-N 50196521 CHEMBL3939100::US10167270, Example 00162::US10501435, Compound 11d Lysosomal acid glucosylceramidase Homo sapiens 10.5 US Patent 10.7270/Q24170FP aid1804032 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196521&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168420 375977478 CHEMBL3939100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853577 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C23H19N3/c1-2-8-16(9-3-1)22-25-21-13-7-6-12-20(21)23(26-22)24-19-14-17-10-4-5-11-18(17)15-19/h1-13,19H,14-15H2,(H,24,25,26) DCLFPHIXBNDNBF-UHFFFAOYSA-N 50196521 CHEMBL3939100::US10167270, Example 00162::US10501435, Compound 11d Lysosomal acid glucosylceramidase Homo sapiens 6.50 US Patent 10.7270/Q24170FP aid1804033 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196521&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168420 375977478 CHEMBL3939100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853578 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C23H19N3/c1-2-8-16(9-3-1)22-25-21-13-7-6-12-20(21)23(26-22)24-19-14-17-10-4-5-11-18(17)15-19/h1-13,19H,14-15H2,(H,24,25,26) DCLFPHIXBNDNBF-UHFFFAOYSA-N 50196521 CHEMBL3939100::US10167270, Example 00162::US10501435, Compound 11d Lysosomal acid glucosylceramidase Homo sapiens 9.40 US Patent 10.7270/Q24170FP aid1804034 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196521&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168420 375977478 CHEMBL3939100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853579 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccs1 InChI=1S/C21H17N3S/c1-2-7-15-13-16(12-14(15)6-1)22-20-17-8-3-4-9-18(17)23-21(24-20)19-10-5-11-25-19/h1-11,16H,12-13H2,(H,22,23,24) YIFJXSPQCBCHCI-UHFFFAOYSA-N 50196519 CHEMBL3930102::US10167270, Example 00163::US10501435, Compound 11f Lysosomal acid glucosylceramidase Homo sapiens 13.9 US Patent 10.7270/Q24170FP aid1804032 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196519&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168091 375977476 CHEMBL3930102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853580 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccs1 InChI=1S/C21H17N3S/c1-2-7-15-13-16(12-14(15)6-1)22-20-17-8-3-4-9-18(17)23-21(24-20)19-10-5-11-25-19/h1-11,16H,12-13H2,(H,22,23,24) YIFJXSPQCBCHCI-UHFFFAOYSA-N 50196519 CHEMBL3930102::US10167270, Example 00163::US10501435, Compound 11f Lysosomal acid glucosylceramidase Homo sapiens 8.20 US Patent 10.7270/Q24170FP aid1804033 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196519&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168091 375977476 CHEMBL3930102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853581 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccs1 InChI=1S/C21H17N3S/c1-2-7-15-13-16(12-14(15)6-1)22-20-17-8-3-4-9-18(17)23-21(24-20)19-10-5-11-25-19/h1-11,16H,12-13H2,(H,22,23,24) YIFJXSPQCBCHCI-UHFFFAOYSA-N 50196519 CHEMBL3930102::US10167270, Example 00163::US10501435, Compound 11f Lysosomal acid glucosylceramidase Homo sapiens 12.9 US Patent 10.7270/Q24170FP aid1804034 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196519&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168091 375977476 CHEMBL3930102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853582 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccsc1 InChI=1S/C21H17N3S/c1-2-6-15-12-17(11-14(15)5-1)22-21-18-7-3-4-8-19(18)23-20(24-21)16-9-10-25-13-16/h1-10,13,17H,11-12H2,(H,22,23,24) JCDASFBLAYXAIQ-UHFFFAOYSA-N 50196623 CHEMBL3976182::US10167270, Example 00164::US10501435, Compound 11g Lysosomal acid glucosylceramidase Homo sapiens 8.90 US Patent 10.7270/Q24170FP aid1804032 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196623&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168348 375977495 CHEMBL3976182 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853583 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccsc1 InChI=1S/C21H17N3S/c1-2-6-15-12-17(11-14(15)5-1)22-21-18-7-3-4-8-19(18)23-20(24-21)16-9-10-25-13-16/h1-10,13,17H,11-12H2,(H,22,23,24) JCDASFBLAYXAIQ-UHFFFAOYSA-N 50196623 CHEMBL3976182::US10167270, Example 00164::US10501435, Compound 11g Lysosomal acid glucosylceramidase Homo sapiens 5.20 US Patent 10.7270/Q24170FP aid1804033 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196623&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168348 375977495 CHEMBL3976182 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 853584 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1ccsc1 InChI=1S/C21H17N3S/c1-2-6-15-12-17(11-14(15)5-1)22-21-18-7-3-4-8-19(18)23-20(24-21)16-9-10-25-13-16/h1-10,13,17H,11-12H2,(H,22,23,24) JCDASFBLAYXAIQ-UHFFFAOYSA-N 50196623 CHEMBL3976182::US10167270, Example 00164::US10501435, Compound 11g Lysosomal acid glucosylceramidase Homo sapiens 6.60 US Patent 10.7270/Q24170FP aid1804034 US10501435 Krainc, D; Silverman, RB; Zheng, J Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196623&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168348 375977495 CHEMBL3976182 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51286569 CCCCCCOCCCCCN1C[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1CO InChI=1S/C17H35NO5/c1-2-3-4-7-10-23-11-8-5-6-9-18-12-15(20)17(22)16(21)14(18)13-19/h14-17,19-22H,2-13H2,1H3/t14-,15+,16-,17-/m0/s1 RCXJPSZNTHETPE-YVSFHVDLSA-N 50524483 CHEMBL4435540 Lysosomal acid glucosylceramidase Homo sapiens 603000 ChEMBL 10.1016/j.ejmech.2019.04.061 10.7270/Q2TB1BBH 31075609 De Fenza, M; D'Alonzo, D; Esposito, A; Munari, S; Loberto, N; Santangelo, A; Lampronti, I; Tamanini, A; Rossi, A; Ranucci, S; De Fino, I; Bragonzi, A; Aureli, M; Bassi, R; Tironi, M; Lippi, G; Gambari, R; Cabrini, G; Palumbo, G; Dechecchi, MC; Guaragna, A University of Napoli Federico II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50524483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50524483&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 155511412 440733065 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51286570 CCCCN1C[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1CO InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m0/s1 UQRORFVVSGFNRO-JXUBOQSCSA-N 50243651 CHEMBL4061367 Lysosomal acid glucosylceramidase Homo sapiens 62000 ChEMBL 10.1016/j.ejmech.2019.04.061 10.7270/Q2TB1BBH 31075609 De Fenza, M; D'Alonzo, D; Esposito, A; Munari, S; Loberto, N; Santangelo, A; Lampronti, I; Tamanini, A; Rossi, A; Ranucci, S; De Fino, I; Bragonzi, A; Aureli, M; Bassi, R; Tironi, M; Lippi, G; Gambari, R; Cabrini, G; Palumbo, G; Dechecchi, MC; Guaragna, A University of Napoli Federico II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50243651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50243651&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 71299592 386402927 CHEMBL4061367 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51286573 CCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C17H35NO5/c1-2-3-4-7-10-23-11-8-5-6-9-18-12-15(20)17(22)16(21)14(18)13-19/h14-17,19-22H,2-13H2,1H3/t14-,15+,16-,17-/m1/s1 RCXJPSZNTHETPE-YYIAUSFCSA-N 50335390 CHEMBL1651630::N-Hexoxypentyl-1-deoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 5400 ChEMBL 10.1016/j.ejmech.2019.04.061 10.7270/Q2TB1BBH 31075609 De Fenza, M; D'Alonzo, D; Esposito, A; Munari, S; Loberto, N; Santangelo, A; Lampronti, I; Tamanini, A; Rossi, A; Ranucci, S; De Fino, I; Bragonzi, A; Aureli, M; Bassi, R; Tironi, M; Lippi, G; Gambari, R; Cabrini, G; Palumbo, G; Dechecchi, MC; Guaragna, A University of Napoli Federico II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335390&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53321623 125085492 CHEMBL1651630 ZINC66102963 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51286576 CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1 FTSCEGKYKXESFF-LXTVHRRPSA-N 18358 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol::N-Nonyl-DNJ Lysosomal acid glucosylceramidase Homo sapiens 5600 ChEMBL 10.1016/j.ejmech.2019.04.061 10.7270/Q2TB1BBH 31075609 De Fenza, M; D'Alonzo, D; Esposito, A; Munari, S; Loberto, N; Santangelo, A; Lampronti, I; Tamanini, A; Rossi, A; Ranucci, S; De Fino, I; Bragonzi, A; Aureli, M; Bassi, R; Tironi, M; Lippi, G; Gambari, R; Cabrini, G; Palumbo, G; Dechecchi, MC; Guaragna, A University of Napoli Federico II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NND 2V3E 501640 46518435 DB08283 ZINC14253608 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51286577 CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 UQRORFVVSGFNRO-UTINFBMNSA-N 18355 (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol::CHEMBL1029::MIGLUSTAT::N-Butyl-DNJ::US9181184, 5 Lysosomal acid glucosylceramidase Homo sapiens 118000 ChEMBL 10.1016/j.ejmech.2019.04.061 10.7270/Q2TB1BBH 31075609 De Fenza, M; D'Alonzo, D; Esposito, A; Munari, S; Loberto, N; Santangelo, A; Lampronti, I; Tamanini, A; Rossi, A; Ranucci, S; De Fino, I; Bragonzi, A; Aureli, M; Bassi, R; Tironi, M; Lippi, G; Gambari, R; Cabrini, G; Palumbo, G; Dechecchi, MC; Guaragna, A University of Napoli Federico II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18355&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NBV 5IEF,2V3D 51634 46518432 50381 CHEMBL1029 DB00419 4841 ZINC03794711 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51286581 CCCCCCCCCN1C[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1CO InChI=1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m0/s1 FTSCEGKYKXESFF-XGUBFFRZSA-N 50524482 CHEMBL4460711 Lysosomal acid glucosylceramidase Homo sapiens 136000 ChEMBL 10.1016/j.ejmech.2019.04.061 10.7270/Q2TB1BBH 31075609 De Fenza, M; D'Alonzo, D; Esposito, A; Munari, S; Loberto, N; Santangelo, A; Lampronti, I; Tamanini, A; Rossi, A; Ranucci, S; De Fino, I; Bragonzi, A; Aureli, M; Bassi, R; Tironi, M; Lippi, G; Gambari, R; Cabrini, G; Palumbo, G; Dechecchi, MC; Guaragna, A University of Napoli Federico II http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50524482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50524482&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 155527701 440733064 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290340 C(COCc1ccccc1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H20N4O/c1-2-7-17(8-3-1)16-27-14-13-24-22-19-10-4-5-11-20(19)25-21(26-22)18-9-6-12-23-15-18/h1-12,15H,13-14,16H2,(H,24,25,26) BBJKIYCPVMDVEB-UHFFFAOYSA-N 313443 US10167270, Example 140 Lysosomal acid glucosylceramidase Homo sapiens 7300 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313443&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168213 383540343 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290341 CN(C1CCCCCC1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-25(17-10-4-2-3-5-11-17)21-18-12-6-7-13-19(18)23-20(24-21)16-9-8-14-22-15-16/h6-9,12-15,17H,2-5,10-11H2,1H3 ZJCRBOCVUBNQMZ-UHFFFAOYSA-N 313430 US10167270, Example 121 Lysosomal acid glucosylceramidase Homo sapiens 9940 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313430&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168429 383540330 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290342 CC(CNc1nc(nc2ccccc12)-c1cccnc1)Oc1ccccc1 InChI=1S/C22H20N4O/c1-16(27-18-9-3-2-4-10-18)14-24-22-19-11-5-6-12-20(19)25-21(26-22)17-8-7-13-23-15-17/h2-13,15-16H,14H2,1H3,(H,24,25,26) RKKRWKMFEZFLPD-UHFFFAOYSA-N 313412 US10167270, Example 92 Lysosomal acid glucosylceramidase Homo sapiens 4240 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313412&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168033 383540312 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290343 CN([C@@H]1CCc2ccccc2C1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C24H22N4/c1-28(20-13-12-17-7-2-3-8-18(17)15-20)24-21-10-4-5-11-22(21)26-23(27-24)19-9-6-14-25-16-19/h2-11,14,16,20H,12-13,15H2,1H3/t20-/m1/s1 VQHVGTSGQUJEJG-HXUWFJFHSA-N 50525974 CHEMBL4444925 Lysosomal acid glucosylceramidase Homo sapiens 5870 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525974&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168198 440734556 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290344 C1Cc2ccccc2C[C@@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m1/s1 NNXTWWKGCDOEQE-LJQANCHMSA-N 50196622 CHEMBL3923147::US10167270, Example 00160::US10501435, Compound 9b Lysosomal acid glucosylceramidase Homo sapiens 9.9 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196622&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168101 375977494 CHEMBL3923147 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290345 CN([C@H]1CCc2ccccc2C1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C24H22N4/c1-28(20-13-12-17-7-2-3-8-18(17)15-20)24-21-10-4-5-11-22(21)26-23(27-24)19-9-6-14-25-16-19/h2-11,14,16,20H,12-13,15H2,1H3/t20-/m0/s1 VQHVGTSGQUJEJG-FQEVSTJZSA-N 313305 US10167270, Example 84 Lysosomal acid glucosylceramidase Homo sapiens 430 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313305&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168088 383540212 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290346 CN(C1Cc2ccccc2C1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-27(19-13-16-7-2-3-8-17(16)14-19)23-20-10-4-5-11-21(20)25-22(26-23)18-9-6-12-24-15-18/h2-12,15,19H,13-14H2,1H3 PNUTXYDXSZENHX-UHFFFAOYSA-N 313224 US10167270, Example 2 Lysosomal acid glucosylceramidase Homo sapiens 2140 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313224&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168024 383540134 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290347 C1C(Cc2ccccc12)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H18N4/c1-2-7-16-13-18(12-15(16)6-1)24-22-19-9-3-4-10-20(19)25-21(26-22)17-8-5-11-23-14-17/h1-11,14,18H,12-13H2,(H,24,25,26) XXCCBJLQMRHXKM-UHFFFAOYSA-N 50196528 CHEMBL3923120::US10167270, Example 00161::US10501435, Compound 9c Lysosomal acid glucosylceramidase Homo sapiens 8.3 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196528&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168025 375977485 CHEMBL3923120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290348 C1CCCC(CCC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H24N4/c1-2-4-10-17(11-5-3-1)23-21-18-12-6-7-13-19(18)24-20(25-21)16-9-8-14-22-15-16/h6-9,12-15,17H,1-5,10-11H2,(H,23,24,25) KPHDEGYZCGJLCL-UHFFFAOYSA-N 50196531 CHEMBL3964444::US10167270, Compound 7a Lysosomal acid glucosylceramidase Homo sapiens 27 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196531&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17546054 375977488 CHEMBL3964444 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290349 C1CCC(C1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C18H18N4/c1-2-8-14(7-1)20-18-15-9-3-4-10-16(15)21-17(22-18)13-6-5-11-19-12-13/h3-6,9-12,14H,1-2,7-8H2,(H,20,21,22) WRPPYAYLCGHEDY-UHFFFAOYSA-N 50196516 CHEMBL3968279::US10167270, Compound 7c Lysosomal acid glucosylceramidase Homo sapiens 720 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196516&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 17391397 375977473 CHEMBL3968279 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290350 C(CCc1ccccc1)CNc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H22N4/c1-2-9-18(10-3-1)11-6-7-16-25-23-20-13-4-5-14-21(20)26-22(27-23)19-12-8-15-24-17-19/h1-5,8-10,12-15,17H,6-7,11,16H2,(H,25,26,27) LXPSTEYVBFGHEM-UHFFFAOYSA-N 50196626 CHEMBL3972062::US10167270, Compound 8e Lysosomal acid glucosylceramidase Homo sapiens 1280 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196626&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168418 375977498 CHEMBL3972062 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290351 C(CNc1nc(nc2ccccc12)-c1cccnc1)Cc1ccccc1 InChI=1S/C22H20N4/c1-2-8-17(9-3-1)10-6-15-24-22-19-12-4-5-13-20(19)25-21(26-22)18-11-7-14-23-16-18/h1-5,7-9,11-14,16H,6,10,15H2,(H,24,25,26) KNPAHIAFSKZRIB-UHFFFAOYSA-N 50196630 CHEMBL3942452::US10167270, Compound 8d Lysosomal acid glucosylceramidase Homo sapiens 1780 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196630&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168417 375977501 CHEMBL3942452 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290352 CC(COc1ccccc1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H20N4O/c1-16(15-27-18-9-3-2-4-10-18)24-22-19-11-5-6-12-20(19)25-21(26-22)17-8-7-13-23-14-17/h2-14,16H,15H2,1H3,(H,24,25,26) KSCVPWHRGWZLOT-UHFFFAOYSA-N 313417 US10167270, Example 97 Lysosomal acid glucosylceramidase Homo sapiens 1880 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313417&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168350 383540317 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290353 C1CCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C19H20N4/c1-2-8-15(9-3-1)21-19-16-10-4-5-11-17(16)22-18(23-19)14-7-6-12-20-13-14/h4-7,10-13,15H,1-3,8-9H2,(H,21,22,23) VTJDAALCLRKSIX-UHFFFAOYSA-N 50196518 CHEMBL3920301::US10167270, Compound 4 Lysosomal acid glucosylceramidase Homo sapiens 177 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196518&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 873720 375977475 CHEMBL3920301 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290354 C(CNc1nc(nc2ccccc12)-c1cccnc1)COc1ccccc1 InChI=1S/C22H20N4O/c1-2-9-18(10-3-1)27-15-7-14-24-22-19-11-4-5-12-20(19)25-21(26-22)17-8-6-13-23-16-17/h1-6,8-13,16H,7,14-15H2,(H,24,25,26) XDCRBXWHGJURAB-UHFFFAOYSA-N 313411 US10167270, Example 91 Lysosomal acid glucosylceramidase Homo sapiens 2540 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=313411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=313411&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168422 383540311 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290355 C1Cc2ccccc2C[C@H]1Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C23H20N4/c1-2-7-17-14-19(12-11-16(17)6-1)25-23-20-9-3-4-10-21(20)26-22(27-23)18-8-5-13-24-15-18/h1-10,13,15,19H,11-12,14H2,(H,25,26,27)/t19-/m0/s1 NNXTWWKGCDOEQE-IBGZPJMESA-N 50196514 CHEMBL3950881::US10167270, Example 00159 Lysosomal acid glucosylceramidase Homo sapiens 8.7 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196514&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168030 375977471 CHEMBL3950881 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290356 CN(C1CCCCCCC1)c1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C22H26N4/c1-26(18-11-5-3-2-4-6-12-18)22-19-13-7-8-14-20(19)24-21(25-22)17-10-9-15-23-16-17/h7-10,13-16,18H,2-6,11-12H2,1H3 AZRKSBPAQBPZIW-UHFFFAOYSA-N 50525975 CHEMBL4530904 Lysosomal acid glucosylceramidase Homo sapiens 8380 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525975&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 124168098 440734557 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290357 C(Cc1ccccc1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C21H18N4/c1-2-7-16(8-3-1)12-14-23-21-18-10-4-5-11-19(18)24-20(25-21)17-9-6-13-22-15-17/h1-11,13,15H,12,14H2,(H,23,24,25) UWQNTLVHUVARDK-UHFFFAOYSA-N 50033286 CHEMBL544818::Phenethyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine; dihydrochloride::US10167270, Compound 8c Lysosomal acid glucosylceramidase Homo sapiens 97 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033286&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 874599 103941603 CHEMBL544818 ZINC00442667 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51290358 C1CCCC(CC1)Nc1nc(nc2ccccc12)-c1cccnc1 InChI=1S/C20H22N4/c1-2-4-10-16(9-3-1)22-20-17-11-5-6-12-18(17)23-19(24-20)15-8-7-13-21-14-15/h5-8,11-14,16H,1-4,9-10H2,(H,22,23,24) REYRWOJVPIEDER-UHFFFAOYSA-N 50196530 CHEMBL3974789::US10167270, Compound 7b Lysosomal acid glucosylceramidase Homo sapiens 42 ChEMBL 10.1021/acs.jmedchem.8b01294 10.7270/Q280562C 30645117 Zheng, J; Jeon, S; Jiang, W; Burbulla, LF; Ysselstein, D; Oevel, K; Krainc, D; Silverman, RB Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196530&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 2456688 375977487 CHEMBL3974789 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51329077 CC\C(=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25- NKANXQFJJICGDU-QPLCGJKRSA-N 20607 (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine::2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine::CHEMBL83::FOSTRIECIN SODIUM::NCGC00024928::Nolvadex::Tamoxifen::Tamoxifen (8)::Tamoxifen, 7::cid_2733526::med.21724, Compound Tamoxifen Lysosomal acid glucosylceramidase Homo sapiens 2500 ChEMBL 10.1016/j.bmcl.2019.126806 10.7270/Q2ZP49NZ 31757667 Childers, W; Fan, R; Martinez, R; Colussi, DJ; Melenski, E; Liu, Y; Gordon, J; Abou-Gharbia, M; Jacobson, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=20607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=20607&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search CTX 6SXF,6OHU,1YA4 2733526 49688681 41774 CHEMBL83 DB00675 1016 C07108 ZINC01530689 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51329078 CCCCC(C(=O)c1ccc(OCCN(C)C)cc1)c1ccccc1\C=C\C InChI=1S/C25H33NO2/c1-5-7-12-24(23-13-9-8-11-20(23)10-6-2)25(27)21-14-16-22(17-15-21)28-19-18-26(3)4/h6,8-11,13-17,24H,5,7,12,18-19H2,1-4H3/b10-6+ ZOJYSLUCYXLFDT-UXBLZVDNSA-N 50537911 CHEMBL4635139 Lysosomal acid glucosylceramidase Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2019.126806 10.7270/Q2ZP49NZ 31757667 Childers, W; Fan, R; Martinez, R; Colussi, DJ; Melenski, E; Liu, Y; Gordon, J; Abou-Gharbia, M; Jacobson, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537911&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 156013990 442139474 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51329079 CCCCC(C(=O)c1ccc(OCCN(C)C)cc1)c1ccccc1C(C)C InChI=1S/C25H35NO2/c1-6-7-10-24(23-12-9-8-11-22(23)19(2)3)25(27)20-13-15-21(16-14-20)28-18-17-26(4)5/h8-9,11-16,19,24H,6-7,10,17-18H2,1-5H3 IOMBAYCDFFHGDR-UHFFFAOYSA-N 50537912 CHEMBL4649463 Lysosomal acid glucosylceramidase Homo sapiens 700 ChEMBL 10.1016/j.bmcl.2019.126806 10.7270/Q2ZP49NZ 31757667 Childers, W; Fan, R; Martinez, R; Colussi, DJ; Melenski, E; Liu, Y; Gordon, J; Abou-Gharbia, M; Jacobson, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537912&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 132183374 442139475 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51329080 CC(C)CC(C(=O)c1ccc(OCCN(C)C)cc1)c1ccccc1C(C)C InChI=1S/C25H35NO2/c1-18(2)17-24(23-10-8-7-9-22(23)19(3)4)25(27)20-11-13-21(14-12-20)28-16-15-26(5)6/h7-14,18-19,24H,15-17H2,1-6H3 QFXZOKPMFZFCJX-UHFFFAOYSA-N 50537913 CHEMBL4647988 Lysosomal acid glucosylceramidase Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2019.126806 10.7270/Q2ZP49NZ 31757667 Childers, W; Fan, R; Martinez, R; Colussi, DJ; Melenski, E; Liu, Y; Gordon, J; Abou-Gharbia, M; Jacobson, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537913&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 132183385 442139476 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51329081 CC(C)CC(C(=O)c1ccc(OCCN(C)C)cc1)c1ccccc1C1CC1 InChI=1S/C25H33NO2/c1-18(2)17-24(23-8-6-5-7-22(23)19-9-10-19)25(27)20-11-13-21(14-12-20)28-16-15-26(3)4/h5-8,11-14,18-19,24H,9-10,15-17H2,1-4H3 UKIWRZPNHUGMIK-UHFFFAOYSA-N 50537914 CHEMBL4636676 Lysosomal acid glucosylceramidase Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2019.126806 10.7270/Q2ZP49NZ 31757667 Childers, W; Fan, R; Martinez, R; Colussi, DJ; Melenski, E; Liu, Y; Gordon, J; Abou-Gharbia, M; Jacobson, MA Temple University School of Pharmacy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537914&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 132183124 442139477 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396797 O[C@@H]1CN[C@H](Cn2cc(nn2)-c2ccc(OCCOCCn3cc(COCC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)NC(=O)c4cc(cc(c4)C(=O)NC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)C(=O)NC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)nn3)cc2)[C@@H]1O InChI=1S/C201H258N66O48/c268-178-76-202-169(187(178)277)103-259-94-160(223-241-259)130-1-19-151(20-2-130)307-64-55-289-46-37-250-85-142(214-232-250)112-298-121-199(122-299-113-143-86-251(233-215-143)38-47-290-56-65-308-152-21-3-131(4-22-152)161-95-260(242-224-161)104-170-188(278)179(269)77-203-170,123-300-114-144-87-252(234-216-144)39-48-291-57-66-309-153-23-5-132(6-24-153)162-96-261(243-225-162)105-171-189(279)180(270)78-204-171)211-196(286)139-73-140(197(287)212-200(124-301-115-145-88-253(235-217-145)40-49-292-58-67-310-154-25-7-133(8-26-154)163-97-262(244-226-163)106-172-190(280)181(271)79-205-172,125-302-116-146-89-254(236-218-146)41-50-293-59-68-311-155-27-9-134(10-28-155)164-98-263(245-227-164)107-173-191(281)182(272)80-206-173)126-303-117-147-90-255(237-219-147)42-51-294-60-69-312-156-29-11-135(12-30-156)165-99-264(246-228-165)108-174-192(282)183(273)81-207-174)75-141(74-139)198(288)213-201(127-304-118-148-91-256(238-220-148)43-52-295-61-70-313-157-31-13-136(14-32-157)166-100-265(247-229-166)109-175-193(283)184(274)82-208-175,128-305-119-149-92-257(239-221-149)44-53-296-62-71-314-158-33-15-137(16-34-158)167-101-266(248-230-167)110-176-194(284)185(275)83-209-176)129-306-120-150-93-258(240-222-150)45-54-297-63-72-315-159-35-17-138(18-36-159)168-102-267(249-231-168)111-177-195(285)186(276)84-210-177/h1-36,73-75,85-102,169-195,202-210,268-285H,37-72,76-84,103-129H2,(H,211,286)(H,212,287)(H,213,288)/t169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,187+,188+,189+,190+,191+,192+,193+,194+,195+/m1/s1 NCWNCLLUJRRPFV-YLLYDAKKSA-N 50564233 CHEMBL4792854 Lysosomal acid glucosylceramidase Homo sapiens 250 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564233&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162670498 461684571 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396798 O[C@@H]1CN[C@@H](Cn2cc(nn2)-c2ccc(OCCOCCn3cc(COCC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)NC(=O)c4cc(cc(c4)C(=O)NC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)C(=O)NC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)nn3)cc2)[C@@H]1O InChI=1S/C201H258N66O48/c268-178-76-202-169(187(178)277)103-259-94-160(223-241-259)130-1-19-151(20-2-130)307-64-55-289-46-37-250-85-142(214-232-250)112-298-121-199(122-299-113-143-86-251(233-215-143)38-47-290-56-65-308-152-21-3-131(4-22-152)161-95-260(242-224-161)104-170-188(278)179(269)77-203-170,123-300-114-144-87-252(234-216-144)39-48-291-57-66-309-153-23-5-132(6-24-153)162-96-261(243-225-162)105-171-189(279)180(270)78-204-171)211-196(286)139-73-140(197(287)212-200(124-301-115-145-88-253(235-217-145)40-49-292-58-67-310-154-25-7-133(8-26-154)163-97-262(244-226-163)106-172-190(280)181(271)79-205-172,125-302-116-146-89-254(236-218-146)41-50-293-59-68-311-155-27-9-134(10-28-155)164-98-263(245-227-164)107-173-191(281)182(272)80-206-173)126-303-117-147-90-255(237-219-147)42-51-294-60-69-312-156-29-11-135(12-30-156)165-99-264(246-228-165)108-174-192(282)183(273)81-207-174)75-141(74-139)198(288)213-201(127-304-118-148-91-256(238-220-148)43-52-295-61-70-313-157-31-13-136(14-32-157)166-100-265(247-229-166)109-175-193(283)184(274)82-208-175,128-305-119-149-92-257(239-221-149)44-53-296-62-71-314-158-33-15-137(16-34-158)167-101-266(248-230-167)110-176-194(284)185(275)83-209-176)129-306-120-150-93-258(240-222-150)45-54-297-63-72-315-159-35-17-138(18-36-159)168-102-267(249-231-168)111-177-195(285)186(276)84-210-177/h1-36,73-75,85-102,169-195,202-210,268-285H,37-72,76-84,103-129H2,(H,211,286)(H,212,287)(H,213,288)/t169-,170-,171-,172-,173-,174-,175-,176-,177-,178+,179+,180+,181+,182+,183+,184+,185+,186+,187-,188-,189-,190-,191-,192-,193-,194-,195-/m0/s1 NCWNCLLUJRRPFV-RHGLHORDSA-N 50564234 CHEMBL4783905 Lysosomal acid glucosylceramidase Homo sapiens 1100 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564234&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162665619 461684572 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396799 COc1ccc(cc1)-c1cn(C[C@H]2NC[C@@H](O)[C@H]2O)nn1 InChI=1S/C14H18N4O3/c1-21-10-4-2-9(3-5-10)11-7-18(17-16-11)8-12-14(20)13(19)6-15-12/h2-5,7,12-15,19-20H,6,8H2,1H3/t12-,13-,14+/m1/s1 ULCQBQQZAQOXJM-MCIONIFRSA-N 50456585 CHEMBL4218664 Lysosomal acid glucosylceramidase Homo sapiens 31000 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456585&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 145971016 433923852 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396800 NC(COCc1cn(CCOCCOc2ccc(cc2)-c2cn(C[C@H]3NC[C@@H](O)[C@H]3O)nn2)nn1)(COCc1cn(CCOCCOc2ccc(cc2)-c2cn(C[C@H]3NC[C@@H](O)[C@H]3O)nn2)nn1)COCc1cn(CCOCCOc2ccc(cc2)-c2cn(C[C@H]3NC[C@@H](O)[C@H]3O)nn2)nn1 InChI=1S/C64H86N22O15/c65-64(40-96-37-46-28-81(75-69-46)13-16-93-19-22-99-49-7-1-43(2-8-49)52-31-84(78-72-52)34-55-61(90)58(87)25-66-55,41-97-38-47-29-82(76-70-47)14-17-94-20-23-100-50-9-3-44(4-10-50)53-32-85(79-73-53)35-56-62(91)59(88)26-67-56)42-98-39-48-30-83(77-71-48)15-18-95-21-24-101-51-11-5-45(6-12-51)54-33-86(80-74-54)36-57-63(92)60(89)27-68-57/h1-12,28-33,55-63,66-68,87-92H,13-27,34-42,65H2/t55-,56-,57-,58-,59-,60-,61+,62+,63+/m1/s1 RFKARSAQDWOGOR-GBEFMBCFSA-N 50564235 CHEMBL4793871 Lysosomal acid glucosylceramidase Homo sapiens 7000 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564235&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162673287 461684573 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396801 O[C@@H]1CN[C@H](Cn2cc(nn2)-c2ccc(OCCOCCn3cc(COCC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(COCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cnnn4CCOCCOc4ccc(cc4)-c4cn(C[C@H]5NC[C@@H](O)[C@H]5O)nn4)nn3)cc2)[C@@H]1O InChI=1S/C84H110N28O20/c113-76-32-85-72(80(76)117)43-107-39-68(93-101-107)56-1-9-64(10-2-56)129-27-23-121-20-17-105-36-60(90-98-105)47-125-51-84(53-127-49-62-38-111(100-92-62)55-124-26-30-132-67-15-7-59(8-16-67)71-42-110(104-96-71)46-75-83(120)79(116)35-88-75,52-126-48-61-37-106(99-91-61)18-21-122-24-28-130-65-11-3-57(4-12-65)69-40-108(102-94-69)44-73-81(118)77(114)33-86-73)54-128-50-63-31-89-97-112(63)19-22-123-25-29-131-66-13-5-58(6-14-66)70-41-109(103-95-70)45-74-82(119)78(115)34-87-74/h1-16,31,36-42,72-83,85-88,113-120H,17-30,32-35,43-55H2/t72-,73-,74-,75-,76-,77-,78-,79-,80+,81+,82+,83+/m1/s1 LNNPBCPMIVSJCP-QJQYWXOKSA-N 50564236 CHEMBL4782789 Lysosomal acid glucosylceramidase Homo sapiens 4800 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564236&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162664765 461684574 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396802 O[C@@H]1CN[C@H](Cn2cc(nn2)-c2ccc(OCCOCCn3cc(COCC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)NC(=O)CCCCC(=O)NC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)nn3)cc2)[C@@H]1O InChI=1S/C134H178N44O32/c179-119-53-135-113(127(119)187)71-173-65-107(149-161-173)89-5-17-101(18-6-89)205-47-41-193-35-29-167-59-95(143-155-167)77-199-83-133(84-200-78-96-60-168(156-144-96)30-36-194-42-48-206-102-19-7-90(8-20-102)108-66-174(162-150-108)72-114-128(188)120(180)54-136-114,85-201-79-97-61-169(157-145-97)31-37-195-43-49-207-103-21-9-91(10-22-103)109-67-175(163-151-109)73-115-129(189)121(181)55-137-115)141-125(185)3-1-2-4-126(186)142-134(86-202-80-98-62-170(158-146-98)32-38-196-44-50-208-104-23-11-92(12-24-104)110-68-176(164-152-110)74-116-130(190)122(182)56-138-116,87-203-81-99-63-171(159-147-99)33-39-197-45-51-209-105-25-13-93(14-26-105)111-69-177(165-153-111)75-117-131(191)123(183)57-139-117)88-204-82-100-64-172(160-148-100)34-40-198-46-52-210-106-27-15-94(16-28-106)112-70-178(166-154-112)76-118-132(192)124(184)58-140-118/h5-28,59-70,113-124,127-132,135-140,179-184,187-192H,1-4,29-58,71-88H2,(H,141,185)(H,142,186)/t113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,127+,128+,129+,130+,131+,132+/m1/s1 MWAPRABGKDDJFP-KNCVKOLQSA-N 50564237 CHEMBL4793095 Lysosomal acid glucosylceramidase Homo sapiens 1300 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564237&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162671141 461684575 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396803 O[C@@H]1CN[C@@H](Cn2cc(nn2)-c2ccc(OCCOCCn3cc(COCC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(COCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cnnn4CCOCCOc4ccc(cc4)-c4cn(C[C@@H]5NC[C@@H](O)[C@H]5O)nn4)nn3)cc2)[C@@H]1O InChI=1S/C84H110N28O20/c113-76-32-85-72(80(76)117)43-107-39-68(93-101-107)56-1-9-64(10-2-56)129-27-23-121-20-17-105-36-60(90-98-105)47-125-51-84(53-127-49-62-38-111(100-92-62)55-124-26-30-132-67-15-7-59(8-16-67)71-42-110(104-96-71)46-75-83(120)79(116)35-88-75,52-126-48-61-37-106(99-91-61)18-21-122-24-28-130-65-11-3-57(4-12-65)69-40-108(102-94-69)44-73-81(118)77(114)33-86-73)54-128-50-63-31-89-97-112(63)19-22-123-25-29-131-66-13-5-58(6-14-66)70-41-109(103-95-70)45-74-82(119)78(115)34-87-74/h1-16,31,36-42,72-83,85-88,113-120H,17-30,32-35,43-55H2/t72-,73-,74-,75-,76+,77+,78+,79+,80-,81-,82-,83-/m0/s1 LNNPBCPMIVSJCP-RAVVQHNTSA-N 50564238 CHEMBL4791125 Lysosomal acid glucosylceramidase Homo sapiens 2900 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564238&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162670941 461684576 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396804 O[C@@H]1CN[C@@H](Cn2cc(nn2)-c2ccc(OCCOCCn3cc(COCC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)NC(=O)CCCCC(=O)NC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)nn3)cc2)[C@@H]1O InChI=1S/C134H178N44O32/c179-119-53-135-113(127(119)187)71-173-65-107(149-161-173)89-5-17-101(18-6-89)205-47-41-193-35-29-167-59-95(143-155-167)77-199-83-133(84-200-78-96-60-168(156-144-96)30-36-194-42-48-206-102-19-7-90(8-20-102)108-66-174(162-150-108)72-114-128(188)120(180)54-136-114,85-201-79-97-61-169(157-145-97)31-37-195-43-49-207-103-21-9-91(10-22-103)109-67-175(163-151-109)73-115-129(189)121(181)55-137-115)141-125(185)3-1-2-4-126(186)142-134(86-202-80-98-62-170(158-146-98)32-38-196-44-50-208-104-23-11-92(12-24-104)110-68-176(164-152-110)74-116-130(190)122(182)56-138-116,87-203-81-99-63-171(159-147-99)33-39-197-45-51-209-105-25-13-93(14-26-105)111-69-177(165-153-111)75-117-131(191)123(183)57-139-117)88-204-82-100-64-172(160-148-100)34-40-198-46-52-210-106-27-15-94(16-28-106)112-70-178(166-154-112)76-118-132(192)124(184)58-140-118/h5-28,59-70,113-124,127-132,135-140,179-184,187-192H,1-4,29-58,71-88H2,(H,141,185)(H,142,186)/t113-,114-,115-,116-,117-,118-,119+,120+,121+,122+,123+,124+,127-,128-,129-,130-,131-,132-/m0/s1 MWAPRABGKDDJFP-RSAKQLFTSA-N 50564239 CHEMBL4779198 Lysosomal acid glucosylceramidase Homo sapiens 4700 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564239&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162663120 461684577 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396805 NC(COCc1cn(CCOCCOc2ccc(cc2)-c2cn(C[C@@H]3NC[C@@H](O)[C@H]3O)nn2)nn1)(COCc1cn(CCOCCOc2ccc(cc2)-c2cn(C[C@@H]3NC[C@@H](O)[C@H]3O)nn2)nn1)COCc1cn(CCOCCOc2ccc(cc2)-c2cn(C[C@@H]3NC[C@@H](O)[C@H]3O)nn2)nn1 InChI=1S/C64H86N22O15/c65-64(40-96-37-46-28-81(75-69-46)13-16-93-19-22-99-49-7-1-43(2-8-49)52-31-84(78-72-52)34-55-61(90)58(87)25-66-55,41-97-38-47-29-82(76-70-47)14-17-94-20-23-100-50-9-3-44(4-10-50)53-32-85(79-73-53)35-56-62(91)59(88)26-67-56)42-98-39-48-30-83(77-71-48)15-18-95-21-24-101-51-11-5-45(6-12-51)54-33-86(80-74-54)36-57-63(92)60(89)27-68-57/h1-12,28-33,55-63,66-68,87-92H,13-27,34-42,65H2/t55-,56-,57-,58+,59+,60+,61-,62-,63-/m0/s1 RFKARSAQDWOGOR-GUHODPNCSA-N 50564240 CHEMBL4786169 Lysosomal acid glucosylceramidase Homo sapiens 38000 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564240&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162667019 461684578 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396806 COc1ccc(cc1)-c1cn(C[C@@H]2NC[C@@H](O)[C@H]2O)nn1 InChI=1S/C14H18N4O3/c1-21-10-4-2-9(3-5-10)11-7-18(17-16-11)8-12-14(20)13(19)6-15-12/h2-5,7,12-15,19-20H,6,8H2,1H3/t12-,13+,14-/m0/s1 ULCQBQQZAQOXJM-MJBXVCDLSA-N 50564241 CHEMBL4214414 Lysosomal acid glucosylceramidase Homo sapiens 39000 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564241&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 145974118 461684579 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396807 O[C@@H]1CN[C@@H](Cn2cc(CCCn3cc(COCC(COCc4cn(CCCc5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCCc5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)NC(=O)CCCCC(=O)NC(COCc4cn(CCCc5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCCc5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCCc5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)nn3)nn2)[C@@H]1O InChI=1S/C92H142N44O20/c137-77-23-93-71(85(77)145)41-131-29-59(101-119-131)9-3-17-125-35-65(107-113-125)47-151-53-91(54-152-48-66-36-126(114-108-66)18-4-10-60-30-132(120-102-60)42-72-86(146)78(138)24-94-72,55-153-49-67-37-127(115-109-67)19-5-11-61-31-133(121-103-61)43-73-87(147)79(139)25-95-73)99-83(143)15-1-2-16-84(144)100-92(56-154-50-68-38-128(116-110-68)20-6-12-62-32-134(122-104-62)44-74-88(148)80(140)26-96-74,57-155-51-69-39-129(117-111-69)21-7-13-63-33-135(123-105-63)45-75-89(149)81(141)27-97-75)58-156-52-70-40-130(118-112-70)22-8-14-64-34-136(124-106-64)46-76-90(150)82(142)28-98-76/h29-40,71-82,85-90,93-98,137-142,145-150H,1-28,41-58H2,(H,99,143)(H,100,144)/t71-,72-,73-,74-,75-,76-,77+,78+,79+,80+,81+,82+,85-,86-,87-,88-,89-,90-/m0/s1 HKHNHXVPPORJPS-OTIYRZJJSA-N 50564242 CHEMBL4795488 Lysosomal acid glucosylceramidase Homo sapiens 333000 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564242&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162673221 461684580 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396808 O[C@@H]1CN[C@@H](Cn2cc(CCCn3cc(COCC(COCc4cn(CCCc5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCCc5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCCc5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)nn3)nn2)[C@@H]1O InChI=1S/C57H88N28O12/c86-49-13-58-45(53(49)90)25-82-17-37(62-74-82)5-1-9-78-21-41(66-70-78)29-94-33-57(34-95-30-42-22-79(71-67-42)10-2-6-38-18-83(75-63-38)26-46-54(91)50(87)14-59-46,35-96-31-43-23-80(72-68-43)11-3-7-39-19-84(76-64-39)27-47-55(92)51(88)15-60-47)36-97-32-44-24-81(73-69-44)12-4-8-40-20-85(77-65-40)28-48-56(93)52(89)16-61-48/h17-24,45-56,58-61,86-93H,1-16,25-36H2/t45-,46-,47-,48-,49+,50+,51+,52+,53-,54-,55-,56-/m0/s1 QYMYLZGURDJOAK-SIBAKFCOSA-N 50564243 CHEMBL4779093 Lysosomal acid glucosylceramidase Homo sapiens 168000 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564243&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162663333 461684581 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396809 CCCc1cn(C[C@@H]2NC[C@@H](O)[C@H]2O)nn1 InChI=1S/C10H18N4O2/c1-2-3-7-5-14(13-12-7)6-8-10(16)9(15)4-11-8/h5,8-11,15-16H,2-4,6H2,1H3/t8-,9+,10-/m0/s1 NCDYRVHMNRRUOD-AEJSXWLSSA-N 50564244 CHEMBL4778683 Lysosomal acid glucosylceramidase Homo sapiens 247000 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564244&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162660847 461684582 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396810 NC(COCc1cn(CCCc2cn(C[C@@H]3NC[C@@H](O)[C@H]3O)nn2)nn1)(COCc1cn(CCCc2cn(C[C@@H]3NC[C@@H](O)[C@H]3O)nn2)nn1)COCc1cn(CCCc2cn(C[C@@H]3NC[C@@H](O)[C@H]3O)nn2)nn1 InChI=1S/C43H68N22O9/c44-43(25-72-22-31-16-60(54-51-31)7-1-4-28-13-63(57-48-28)19-34-40(69)37(66)10-45-34,26-73-23-32-17-61(55-52-32)8-2-5-29-14-64(58-49-29)20-35-41(70)38(67)11-46-35)27-74-24-33-18-62(56-53-33)9-3-6-30-15-65(59-50-30)21-36-42(71)39(68)12-47-36/h13-18,34-42,45-47,66-71H,1-12,19-27,44H2/t34-,35-,36-,37+,38+,39+,40-,41-,42-/m0/s1 IPPFXCKDEUEEGW-DSFSATKBSA-N 50564245 CHEMBL4794112 Lysosomal acid glucosylceramidase Homo sapiens 725000 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564245&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162673546 461684583 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396811 O[C@@H]1CN[C@H](Cn2cc(nn2)-c2ccc(OCCOCCn3cc(COCC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(COCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cnnn4CCOCCOc4ccc(cc4)-c4cn(C[C@H]5NC[C@@H](O)[C@H]5O)nn4)nn3)cc2)[C@@H]1O InChI=1S/C84H110N28O20/c113-76-32-85-72(80(76)117)43-107-39-68(93-101-107)56-1-9-64(10-2-56)129-27-23-121-20-17-105-36-60(90-98-105)47-125-51-84(53-127-49-62-38-111(100-92-62)55-124-26-30-132-67-15-7-59(8-16-67)71-42-110(104-96-71)46-75-83(120)79(116)35-88-75,52-126-48-61-37-106(99-91-61)18-21-122-24-28-130-65-11-3-57(4-12-65)69-40-108(102-94-69)44-73-81(118)77(114)33-86-73)54-128-50-63-31-89-97-112(63)19-22-123-25-29-131-66-13-5-58(6-14-66)70-41-109(103-95-70)45-74-82(119)78(115)34-87-74/h1-16,31,36-42,72-83,85-88,113-120H,17-30,32-35,43-55H2/t72-,73-,74-,75-,76-,77-,78-,79-,80+,81+,82+,83+/m1/s1 LNNPBCPMIVSJCP-QJQYWXOKSA-N 50564236 CHEMBL4782789 Lysosomal acid glucosylceramidase Homo sapiens 2600 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564236&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162664765 461684574 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396812 COc1ccc(cc1)-c1cn(C[C@@H]2NC[C@@H](O)[C@H]2O)nn1 InChI=1S/C14H18N4O3/c1-21-10-4-2-9(3-5-10)11-7-18(17-16-11)8-12-14(20)13(19)6-15-12/h2-5,7,12-15,19-20H,6,8H2,1H3/t12-,13+,14-/m0/s1 ULCQBQQZAQOXJM-MJBXVCDLSA-N 50564241 CHEMBL4214414 Lysosomal acid glucosylceramidase Homo sapiens 55000 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564241&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 145974118 461684579 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396813 NC(COCc1cn(CCOCCOc2ccc(cc2)-c2cn(C[C@H]3NC[C@@H](O)[C@H]3O)nn2)nn1)(COCc1cn(CCOCCOc2ccc(cc2)-c2cn(C[C@H]3NC[C@@H](O)[C@H]3O)nn2)nn1)COCc1cn(CCOCCOc2ccc(cc2)-c2cn(C[C@H]3NC[C@@H](O)[C@H]3O)nn2)nn1 InChI=1S/C64H86N22O15/c65-64(40-96-37-46-28-81(75-69-46)13-16-93-19-22-99-49-7-1-43(2-8-49)52-31-84(78-72-52)34-55-61(90)58(87)25-66-55,41-97-38-47-29-82(76-70-47)14-17-94-20-23-100-50-9-3-44(4-10-50)53-32-85(79-73-53)35-56-62(91)59(88)26-67-56)42-98-39-48-30-83(77-71-48)15-18-95-21-24-101-51-11-5-45(6-12-51)54-33-86(80-74-54)36-57-63(92)60(89)27-68-57/h1-12,28-33,55-63,66-68,87-92H,13-27,34-42,65H2/t55-,56-,57-,58-,59-,60-,61+,62+,63+/m1/s1 RFKARSAQDWOGOR-GBEFMBCFSA-N 50564235 CHEMBL4793871 Lysosomal acid glucosylceramidase Homo sapiens 5400 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564235&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162673287 461684573 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396814 COc1ccc(cc1)-c1cn(C[C@H]2NC[C@@H](O)[C@H]2O)nn1 InChI=1S/C14H18N4O3/c1-21-10-4-2-9(3-5-10)11-7-18(17-16-11)8-12-14(20)13(19)6-15-12/h2-5,7,12-15,19-20H,6,8H2,1H3/t12-,13-,14+/m1/s1 ULCQBQQZAQOXJM-MCIONIFRSA-N 50456585 CHEMBL4218664 Lysosomal acid glucosylceramidase Homo sapiens 19000 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50456585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50456585&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 145971016 433923852 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396815 O[C@@H]1CN[C@@H](Cn2cc(nn2)-c2ccc(OCCOCCn3cc(COCC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)NC(=O)c4cc(cc(c4)C(=O)NC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)C(=O)NC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)nn3)cc2)[C@@H]1O 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NCWNCLLUJRRPFV-RHGLHORDSA-N 50564234 CHEMBL4783905 Lysosomal acid glucosylceramidase Homo sapiens 1100 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564234&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162665619 461684572 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396816 O[C@@H]1CN[C@@H](Cn2cc(nn2)-c2ccc(OCCOCCn3cc(COCC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)NC(=O)CCCCC(=O)NC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)nn3)cc2)[C@@H]1O InChI=1S/C134H178N44O32/c179-119-53-135-113(127(119)187)71-173-65-107(149-161-173)89-5-17-101(18-6-89)205-47-41-193-35-29-167-59-95(143-155-167)77-199-83-133(84-200-78-96-60-168(156-144-96)30-36-194-42-48-206-102-19-7-90(8-20-102)108-66-174(162-150-108)72-114-128(188)120(180)54-136-114,85-201-79-97-61-169(157-145-97)31-37-195-43-49-207-103-21-9-91(10-22-103)109-67-175(163-151-109)73-115-129(189)121(181)55-137-115)141-125(185)3-1-2-4-126(186)142-134(86-202-80-98-62-170(158-146-98)32-38-196-44-50-208-104-23-11-92(12-24-104)110-68-176(164-152-110)74-116-130(190)122(182)56-138-116,87-203-81-99-63-171(159-147-99)33-39-197-45-51-209-105-25-13-93(14-26-105)111-69-177(165-153-111)75-117-131(191)123(183)57-139-117)88-204-82-100-64-172(160-148-100)34-40-198-46-52-210-106-27-15-94(16-28-106)112-70-178(166-154-112)76-118-132(192)124(184)58-140-118/h5-28,59-70,113-124,127-132,135-140,179-184,187-192H,1-4,29-58,71-88H2,(H,141,185)(H,142,186)/t113-,114-,115-,116-,117-,118-,119+,120+,121+,122+,123+,124+,127-,128-,129-,130-,131-,132-/m0/s1 MWAPRABGKDDJFP-RSAKQLFTSA-N 50564239 CHEMBL4779198 Lysosomal acid glucosylceramidase Homo sapiens 2700 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564239&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162663120 461684577 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396817 O[C@@H]1CN[C@H](Cn2cc(nn2)-c2ccc(OCCOCCn3cc(COCC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)NC(=O)c4cc(cc(c4)C(=O)NC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)C(=O)NC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)nn3)cc2)[C@@H]1O InChI=1S/C201H258N66O48/c268-178-76-202-169(187(178)277)103-259-94-160(223-241-259)130-1-19-151(20-2-130)307-64-55-289-46-37-250-85-142(214-232-250)112-298-121-199(122-299-113-143-86-251(233-215-143)38-47-290-56-65-308-152-21-3-131(4-22-152)161-95-260(242-224-161)104-170-188(278)179(269)77-203-170,123-300-114-144-87-252(234-216-144)39-48-291-57-66-309-153-23-5-132(6-24-153)162-96-261(243-225-162)105-171-189(279)180(270)78-204-171)211-196(286)139-73-140(197(287)212-200(124-301-115-145-88-253(235-217-145)40-49-292-58-67-310-154-25-7-133(8-26-154)163-97-262(244-226-163)106-172-190(280)181(271)79-205-172,125-302-116-146-89-254(236-218-146)41-50-293-59-68-311-155-27-9-134(10-28-155)164-98-263(245-227-164)107-173-191(281)182(272)80-206-173)126-303-117-147-90-255(237-219-147)42-51-294-60-69-312-156-29-11-135(12-30-156)165-99-264(246-228-165)108-174-192(282)183(273)81-207-174)75-141(74-139)198(288)213-201(127-304-118-148-91-256(238-220-148)43-52-295-61-70-313-157-31-13-136(14-32-157)166-100-265(247-229-166)109-175-193(283)184(274)82-208-175,128-305-119-149-92-257(239-221-149)44-53-296-62-71-314-158-33-15-137(16-34-158)167-101-266(248-230-167)110-176-194(284)185(275)83-209-176)129-306-120-150-93-258(240-222-150)45-54-297-63-72-315-159-35-17-138(18-36-159)168-102-267(249-231-168)111-177-195(285)186(276)84-210-177/h1-36,73-75,85-102,169-195,202-210,268-285H,37-72,76-84,103-129H2,(H,211,286)(H,212,287)(H,213,288)/t169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,187+,188+,189+,190+,191+,192+,193+,194+,195+/m1/s1 NCWNCLLUJRRPFV-YLLYDAKKSA-N 50564233 CHEMBL4792854 Lysosomal acid glucosylceramidase Homo sapiens 770 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564233&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162670498 461684571 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396818 O[C@@H]1CN[C@@H](Cn2cc(nn2)-c2ccc(OCCOCCn3cc(COCC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(COCCOc5ccc(cc5)-c5cn(C[C@@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cnnn4CCOCCOc4ccc(cc4)-c4cn(C[C@@H]5NC[C@@H](O)[C@H]5O)nn4)nn3)cc2)[C@@H]1O InChI=1S/C84H110N28O20/c113-76-32-85-72(80(76)117)43-107-39-68(93-101-107)56-1-9-64(10-2-56)129-27-23-121-20-17-105-36-60(90-98-105)47-125-51-84(53-127-49-62-38-111(100-92-62)55-124-26-30-132-67-15-7-59(8-16-67)71-42-110(104-96-71)46-75-83(120)79(116)35-88-75,52-126-48-61-37-106(99-91-61)18-21-122-24-28-130-65-11-3-57(4-12-65)69-40-108(102-94-69)44-73-81(118)77(114)33-86-73)54-128-50-63-31-89-97-112(63)19-22-123-25-29-131-66-13-5-58(6-14-66)70-41-109(103-95-70)45-74-82(119)78(115)34-87-74/h1-16,31,36-42,72-83,85-88,113-120H,17-30,32-35,43-55H2/t72-,73-,74-,75-,76+,77+,78+,79+,80-,81-,82-,83-/m0/s1 LNNPBCPMIVSJCP-RAVVQHNTSA-N 50564238 CHEMBL4791125 Lysosomal acid glucosylceramidase Homo sapiens 1600 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564238&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162670941 461684576 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396819 O[C@@H]1CN[C@H](Cn2cc(nn2)-c2ccc(OCCOCCn3cc(COCC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)NC(=O)CCCCC(=O)NC(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)(COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)COCc4cn(CCOCCOc5ccc(cc5)-c5cn(C[C@H]6NC[C@@H](O)[C@H]6O)nn5)nn4)nn3)cc2)[C@@H]1O InChI=1S/C134H178N44O32/c179-119-53-135-113(127(119)187)71-173-65-107(149-161-173)89-5-17-101(18-6-89)205-47-41-193-35-29-167-59-95(143-155-167)77-199-83-133(84-200-78-96-60-168(156-144-96)30-36-194-42-48-206-102-19-7-90(8-20-102)108-66-174(162-150-108)72-114-128(188)120(180)54-136-114,85-201-79-97-61-169(157-145-97)31-37-195-43-49-207-103-21-9-91(10-22-103)109-67-175(163-151-109)73-115-129(189)121(181)55-137-115)141-125(185)3-1-2-4-126(186)142-134(86-202-80-98-62-170(158-146-98)32-38-196-44-50-208-104-23-11-92(12-24-104)110-68-176(164-152-110)74-116-130(190)122(182)56-138-116,87-203-81-99-63-171(159-147-99)33-39-197-45-51-209-105-25-13-93(14-26-105)111-69-177(165-153-111)75-117-131(191)123(183)57-139-117)88-204-82-100-64-172(160-148-100)34-40-198-46-52-210-106-27-15-94(16-28-106)112-70-178(166-154-112)76-118-132(192)124(184)58-140-118/h5-28,59-70,113-124,127-132,135-140,179-184,187-192H,1-4,29-58,71-88H2,(H,141,185)(H,142,186)/t113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,127+,128+,129+,130+,131+,132+/m1/s1 MWAPRABGKDDJFP-KNCVKOLQSA-N 50564237 CHEMBL4793095 Lysosomal acid glucosylceramidase Homo sapiens 1200 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564237&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162671141 461684575 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51396820 NC(COCc1cn(CCOCCOc2ccc(cc2)-c2cn(C[C@@H]3NC[C@@H](O)[C@H]3O)nn2)nn1)(COCc1cn(CCOCCOc2ccc(cc2)-c2cn(C[C@@H]3NC[C@@H](O)[C@H]3O)nn2)nn1)COCc1cn(CCOCCOc2ccc(cc2)-c2cn(C[C@@H]3NC[C@@H](O)[C@H]3O)nn2)nn1 InChI=1S/C64H86N22O15/c65-64(40-96-37-46-28-81(75-69-46)13-16-93-19-22-99-49-7-1-43(2-8-49)52-31-84(78-72-52)34-55-61(90)58(87)25-66-55,41-97-38-47-29-82(76-70-47)14-17-94-20-23-100-50-9-3-44(4-10-50)53-32-85(79-73-53)35-56-62(91)59(88)26-67-56)42-98-39-48-30-83(77-71-48)15-18-95-21-24-101-51-11-5-45(6-12-51)54-33-86(80-74-54)36-57-63(92)60(89)27-68-57/h1-12,28-33,55-63,66-68,87-92H,13-27,34-42,65H2/t55-,56-,57-,58+,59+,60+,61-,62-,63-/m0/s1 RFKARSAQDWOGOR-GUHODPNCSA-N 50564240 CHEMBL4786169 Lysosomal acid glucosylceramidase Homo sapiens 55000 ChEMBL 10.1016/j.ejmech.2020.112173 10.7270/Q2H998X6 32146376 Martínez-Bailén, M; Carmona, AT; Cardona, F; Matassini, C; Goti, A; Kubo, M; Kato, A; Robina, I; Moreno-Vargas, AJ Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564240&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 162667019 461684578 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51451194 CC(C)(O)c1ccc(NC(=O)c2ccnn(-c3ccccc3OCC(F)(F)F)c2=O)cc1 InChI=1S/C22H20F3N3O4/c1-21(2,31)14-7-9-15(10-8-14)27-19(29)16-11-12-26-28(20(16)30)17-5-3-4-6-18(17)32-13-22(23,24)25/h3-12,31H,13H2,1-2H3,(H,27,29) CQAPXPSWLDAVEG-UHFFFAOYSA-N 50585896 CHEMBL5085509 Lysosomal acid glucosylceramidase Homo sapiens >300000 ChEMBL 10.1021/acs.jmedchem.1c02078 10.7270/Q2KW5KZB 35188773 Tanaka, Y; Seto, M; Kakegawa, K; Takami, K; Kikuchi, F; Yamamoto, T; Nakamura, M; Daini, M; Murakami, M; Ohashi, T; Kasahara, T; Wang, J; Ikeda, Z; Wada, Y; Puenner, F; Fujii, T; Inazuka, M; Sato, S; Suzaki, T; Oak, JH; Takai, Y; Kohara, H; Kimoto, K; Oki, H; Mikami, S; Sasaki, M; Tanaka, Y Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585896&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 155595153 476021983 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484851 OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 LXBIFEVIBLOUGU-JGWLITMVSA-N 18351 (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10::(2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol::1-Deoxynojirimycin::1-deoxynojirimycin (DNJ)::CHEMBL307429::US9181184, 1::dNM Lysosomal acid glucosylceramidase Homo sapiens 240000 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DNJ 1DIE,1DOG,1I75,1OIM,2J77,2JKE,2PWD,3GBE,3GXT 29435 46518429 44369 CHEMBL307429 4642 C16843 ZINC03794714 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484852 CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1 UQRORFVVSGFNRO-UTINFBMNSA-N 18355 (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol::CHEMBL1029::MIGLUSTAT::N-Butyl-DNJ::US9181184, 5 Lysosomal acid glucosylceramidase Homo sapiens 270000 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18355&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search NBV 5IEF,2V3D 51634 46518432 50381 CHEMBL1029 DB00419 4841 ZINC03794711 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484853 CCCCCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C18H37NO4/c1-2-3-4-5-6-7-8-9-10-11-12-19-13-16(21)18(23)17(22)15(19)14-20/h15-18,20-23H,2-14H2,1H3/t15-,16+,17-,18-/m1/s1 TYXAKMAAZJJHCB-XMTFNYHQSA-N 50242628 CHEMBL450985::N-dodecyldeoxynojirimycin Lysosomal acid glucosylceramidase Homo sapiens 50 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242628&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 9818954 104099157 CHEMBL450985 ZINC44351037 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484854 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 40 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484855 CCCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1 InChI=1S/C10H21NO3/c1-2-3-4-11-5-8(7-12)10(14)9(13)6-11/h8-10,12-14H,2-7H2,1H3/t8-,9-,10-/m1/s1 MNMGUPFDAVSAED-OPRDCNLKSA-N 50598372 CHEMBL5175538 Lysosomal acid glucosylceramidase Homo sapiens 44000 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598372&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10130427 482609224 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484856 CCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C10H21NO3/c1-2-3-4-5-7-9(13)10(14)8(6-12)11-7/h7-14H,2-6H2,1H3/t7-,8-,9-,10-/m1/s1 DPMOGEIHEVCZMA-ZYUZMQFOSA-N 50598373 CHEMBL5202795 Lysosomal acid glucosylceramidase Homo sapiens 34000 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598373&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 168293213 482609225 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484857 CCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C11H23NO3/c1-2-3-4-5-6-8-10(14)11(15)9(7-13)12-8/h8-15H,2-7H2,1H3/t8-,9-,10-,11-/m1/s1 QMSPEQOEFDFBDC-GWOFURMSSA-N 50598374 CHEMBL5201364 Lysosomal acid glucosylceramidase Homo sapiens 30000 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598374&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 168291541 482609226 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484858 CCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C12H25NO3/c1-2-3-4-5-6-7-9-11(15)12(16)10(8-14)13-9/h9-16H,2-8H2,1H3/t9-,10-,11-,12-/m1/s1 ZHCDSIQDIBIMCV-DDHJBXDOSA-N 50598375 CHEMBL5185978 Lysosomal acid glucosylceramidase Homo sapiens 38000 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598375&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 168282228 482609227 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484859 CCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C13H27NO3/c1-2-3-4-5-6-7-8-10-12(16)13(17)11(9-15)14-10/h10-17H,2-9H2,1H3/t10-,11-,12-,13-/m1/s1 SDYXGHBDCJJNMV-FDYHWXHSSA-N 50598376 CHEMBL5206213 Lysosomal acid glucosylceramidase Homo sapiens 6200 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598376&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52939737 482609228 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484860 CCCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C14H29NO3/c1-2-3-4-5-6-7-8-9-11-13(17)14(18)12(10-16)15-11/h11-18H,2-10H2,1H3/t11-,12-,13-,14-/m1/s1 DRNPXCOTCYRPEY-AAVRWANBSA-N 50598377 CHEMBL5206557 Lysosomal acid glucosylceramidase Homo sapiens 3300 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598377&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 168296253 482609229 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484861 CCCCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C15H31NO3/c1-2-3-4-5-6-7-8-9-10-12-14(18)15(19)13(11-17)16-12/h12-19H,2-11H2,1H3/t12-,13-,14-,15-/m1/s1 OMRHAMJXOJCJAO-KBUPBQIOSA-N 50598378 CHEMBL5203567 Lysosomal acid glucosylceramidase Homo sapiens 1900 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598378&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 168293395 482609230 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484862 CCCCCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C16H33NO3/c1-2-3-4-5-6-7-8-9-10-11-13-15(19)16(20)14(12-18)17-13/h13-20H,2-12H2,1H3/t13-,14-,15-,16-/m1/s1 ZFHPRXXBOYYMCJ-KLHDSHLOSA-N 50598379 CHEMBL5208500 Lysosomal acid glucosylceramidase Homo sapiens 2300 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598379&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 168297718 482609231 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484863 CCCCCCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C17H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-14-16(20)17(21)15(13-19)18-14/h14-21H,2-13H2,1H3/t14-,15-,16-,17-/m1/s1 DDKLZDILUXXVQV-QBPKDAKJSA-N 50598380 CHEMBL5176016 Lysosomal acid glucosylceramidase Homo sapiens 1500 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598380&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 168272546 482609232 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484864 CCCCCCCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C18H37NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-17(21)18(22)16(14-20)19-15/h15-22H,2-14H2,1H3/t15-,16-,17-,18-/m1/s1 UGACFOJZAZEING-BRSBDYLESA-N 50598381 CHEMBL5172851 Lysosomal acid glucosylceramidase Homo sapiens 770 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598381&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 132557843 482609233 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484865 CCCCCCCCC[C@@H]1NC[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C15H31NO3/c1-2-3-4-5-6-7-8-9-13-12(11-17)15(19)14(18)10-16-13/h12-19H,2-11H2,1H3/t12-,13-,14+,15+/m0/s1 FAUJNJKIHJSYDO-BYNSBNAKSA-N 50598382 CHEMBL5192083 Lysosomal acid glucosylceramidase Homo sapiens 0.600000 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598382&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 11300283 482609234 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484866 O[C@H]1CN[C@H]([C@@H]1O)c1ccccc1 InChI=1S/C10H13NO2/c12-8-6-11-9(10(8)13)7-4-2-1-3-5-7/h1-5,8-13H,6H2/t8-,9-,10+/m0/s1 ZYKVHGYTSPUHNA-LPEHRKFASA-N 50598383 CHEMBL5199229 Lysosomal acid glucosylceramidase Homo sapiens 26500 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598383&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10856057 482609235 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484867 OC[C@H]1N[C@H](CCCCCCCC2CCc3ccccc3C2)[C@@H](O)[C@@H]1O InChI=1S/C22H35NO3/c24-15-20-22(26)21(25)19(23-20)11-5-3-1-2-4-8-16-12-13-17-9-6-7-10-18(17)14-16/h6-7,9-10,16,19-26H,1-5,8,11-15H2/t16?,19-,20-,21-,22-/m1/s1 INZOIBIOQAJDOV-BTFIMFBOSA-N 50598384 CHEMBL5190439 Lysosomal acid glucosylceramidase Homo sapiens 820 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598384&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 168281212 482609236 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484868 O[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ RMCNETIHECSPMZ-SCDXWVJYSA-N 50182798 (3R,4r,5S)-piperidine-3,4,5-triol::1,5-Dideoxy-1,5-imino-D-xylitol::CHEMBL110830::PIPERIDINE-3,4,5-TRIOL Lysosomal acid glucosylceramidase Homo sapiens 1900 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182798&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search XDN 1V0K,1FH7,1V0M 445612 104067413 CHEMBL110830 ZINC14658010 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484869 CCCCCCCCCC1NC[C@@H](O)[C@H](O)[C@H]1O InChI=1S/C14H29NO3/c1-2-3-4-5-6-7-8-9-11-13(17)14(18)12(16)10-15-11/h11-18H,2-10H2,1H3/t11?,12-,13+,14+/m1/s1 WVYPOMDXOXCTJU-LHBNMAMBSA-N 50598385 CHEMBL5189151 Lysosomal acid glucosylceramidase Homo sapiens 6.8 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598385&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 168290906 482609237 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51484870 CCCCCCO[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C11H23NO3/c1-2-3-4-5-6-15-10-8-12-7-9(13)11(10)14/h9-14H,2-8H2,1H3/t9-,10+,11+/m1/s1 YLAJZSYMTLQYDO-VWYCJHECSA-N 50598386 CHEMBL3393682 Lysosomal acid glucosylceramidase Homo sapiens 9.0 ChEMBL 10.7270/Q2Z89HFH 35675756 Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598386&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 118725591 482609238 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 1352388 OC[C@H]1OC(Oc2ccc(cc2N(=O)=O)N(=O)=O)[C@H](F)[C@@H](O)[C@@H]1O InChI=1S/C12H13FN2O9/c13-9-11(18)10(17)8(4-16)24-12(9)23-7-2-1-5(14(19)20)3-6(7)15(21)22/h1-3,8-12,16-18H,4H2/t8-,9-,10-,11-,12?/m1/s1 UFSBFVZQJZMIOU-PRFVCTMUSA-N 636733 US11826435, Compound 1.1 Lysosomal acid glucosylceramidase Homo sapiens >1000000 US Patent 10.7270/Q27H1PQ1 US11826435 Phenix, C; Tesolin, D; Chowdhury, M; Wang, S University Of Saskatchewan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=636733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=636733&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 1352389 O[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/m0/s1 ZHMWOVGZCINIHW-FTYOSCRSSA-N 50078114 (1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,3,4,5-tetraol::CHEMBL291020::Conduritol B Epoxide::Conduritol B Epoxide, 2::US11826435, Compound 1.2::US9056847, Conduritol B- epoxide Lysosomal acid glucosylceramidase Homo sapiens 9490 US Patent 10.7270/Q27H1PQ1 US11826435 Phenix, C; Tesolin, D; Chowdhury, M; Wang, S University Of Saskatchewan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078114&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 119054 103970749 67235 CHEMBL291020 ZINC17995199 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 1352390 O[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/m0/s1 ZHMWOVGZCINIHW-FTYOSCRSSA-N 50078114 (1S,2R,3S,4S,5R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,3,4,5-tetraol::CHEMBL291020::Conduritol B Epoxide::Conduritol B Epoxide, 2::US11826435, Compound 1.2::US9056847, Conduritol B- epoxide Lysosomal acid glucosylceramidase Homo sapiens 140000 US Patent 10.7270/Q27H1PQ1 US11826435 Phenix, C; Tesolin, D; Chowdhury, M; Wang, S University Of Saskatchewan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078114&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 119054 103970749 67235 CHEMBL291020 ZINC17995199 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 1352391 OC[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C7H12O5/c8-1-2-3(9)4(10)5(11)7-6(2)12-7/h2-11H,1H2/t2-,3-,4+,5-,6-,7+/m1/s1 YQLWKYQDOQEWRD-GEGSFZHJSA-N 36512 CID164227::Cylcophellitol, 3::US11826435, Compound 1.3 Lysosomal acid glucosylceramidase Homo sapiens 152 US Patent 10.7270/Q27H1PQ1 US11826435 Phenix, C; Tesolin, D; Chowdhury, M; Wang, S University Of Saskatchewan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36512&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 164227 117644098 ZINC05131881 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 1352392 CCCN1C2C1[C@H](O)[C@@H](O)[C@H](O)[C@H]2O InChI=1S/C9H17NO4/c1-2-3-10-4-5(10)7(12)9(14)8(13)6(4)11/h4-9,11-14H,2-3H2,1H3/t4?,5?,6-,7-,8+,9+,10?/m0/s1 RRVBPOCNJRHDON-JOYGOWPLSA-N 636736 US11826435, Compound 1.5 Lysosomal acid glucosylceramidase Homo sapiens 2400 US Patent 10.7270/Q27H1PQ1 US11826435 Phenix, C; Tesolin, D; Chowdhury, M; Wang, S University Of Saskatchewan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=636736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=636736&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 1352393 CCCCCN1C2C1[C@H](O)[C@@H](O)[C@H](O)[C@H]2O InChI=1S/C11H21NO4/c1-2-3-4-5-12-6-7(12)9(14)11(16)10(15)8(6)13/h6-11,13-16H,2-5H2,1H3/t6?,7?,8-,9-,10+,11+,12?/m0/s1 GSFJOEAZLRJMPB-IZZURGMMSA-N 636737 US11826435, Compound 1.6 Lysosomal acid glucosylceramidase Homo sapiens 50.0 US Patent 10.7270/Q27H1PQ1 US11826435 Phenix, C; Tesolin, D; Chowdhury, M; Wang, S University Of Saskatchewan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=636737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=636737&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 1352394 CCCCCCCN1C2C1[C@H](O)[C@@H](O)[C@H](O)[C@H]2O InChI=1S/C13H25NO4/c1-2-3-4-5-6-7-14-8-9(14)11(16)13(18)12(17)10(8)15/h8-13,15-18H,2-7H2,1H3/t8?,9?,10-,11-,12+,13+,14?/m0/s1 PMINCFDMOPGTSK-MHQHDMIQSA-N 636738 US11826435, Compound 1.7 Lysosomal acid glucosylceramidase Homo sapiens 5.00 US Patent 10.7270/Q27H1PQ1 US11826435 Phenix, C; Tesolin, D; Chowdhury, M; Wang, S University Of Saskatchewan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=636738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=636738&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516536 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccccc1C InChI=1S/C21H27N5O/c1-16-7-3-4-8-18(16)20(27)25-13-11-24(12-14-25)19-15-17(2)22-21(23-19)26-9-5-6-10-26/h3-4,7-8,15H,5-6,9-14H2,1-2H3 KGRHWSYWTJSLKU-UHFFFAOYSA-N 50610337 CHEMBL5271750 Lysosomal acid glucosylceramidase Homo sapiens 75 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610337&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047579 494500085 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516537 CC(C)c1nc(C)cc(n1)N1CCN(CC1)C(=O)c1ccccc1C InChI=1S/C20H26N4O/c1-14(2)19-21-16(4)13-18(22-19)23-9-11-24(12-10-23)20(25)17-8-6-5-7-15(17)3/h5-8,13-14H,9-12H2,1-4H3 VDOOTQOGYAFQLQ-UHFFFAOYSA-N 50610338 CHEMBL5265984 Lysosomal acid glucosylceramidase Homo sapiens 150 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610338&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 18120110 494500086 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516538 Cc1cc(nc(n1)N1CCC1)N1CCN(CC1)C(=O)c1ccccc1C InChI=1S/C20H25N5O/c1-15-6-3-4-7-17(15)19(26)24-12-10-23(11-13-24)18-14-16(2)21-20(22-18)25-8-5-9-25/h3-4,6-7,14H,5,8-13H2,1-2H3 PLXWUNBTMKXCMW-UHFFFAOYSA-N 50610339 CHEMBL5271587 Lysosomal acid glucosylceramidase Homo sapiens 440 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610339&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171343356 494500087 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516539 CN(C)c1nc(C)cc(n1)N1CCN(CC1)C(=O)c1ccccc1C InChI=1S/C19H25N5O/c1-14-7-5-6-8-16(14)18(25)24-11-9-23(10-12-24)17-13-15(2)20-19(21-17)22(3)4/h5-8,13H,9-12H2,1-4H3 WSFKAACZXGOARN-UHFFFAOYSA-N 50610340 CHEMBL5272591 Lysosomal acid glucosylceramidase Homo sapiens 630 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610340&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171346808 494500088 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516540 Cc1cc(nc(n1)N1CCCCC1)N1CCN(CC1)C(=O)c1ccccc1C InChI=1S/C22H29N5O/c1-17-8-4-5-9-19(17)21(28)26-14-12-25(13-15-26)20-16-18(2)23-22(24-20)27-10-6-3-7-11-27/h4-5,8-9,16H,3,6-7,10-15H2,1-2H3 KTCRYTJPCBTFKP-UHFFFAOYSA-N 50610341 CHEMBL5278339 Lysosomal acid glucosylceramidase Homo sapiens 170 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610341&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047604 494500089 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516541 Cc1cc(nc(n1)N1CCCCCC1)N1CCN(CC1)C(=O)c1ccccc1C InChI=1S/C23H31N5O/c1-18-9-5-6-10-20(18)22(29)27-15-13-26(14-16-27)21-17-19(2)24-23(25-21)28-11-7-3-4-8-12-28/h5-6,9-10,17H,3-4,7-8,11-16H2,1-2H3 MEEPMNRUTBVDGQ-UHFFFAOYSA-N 50610342 CHEMBL5266290 Lysosomal acid glucosylceramidase Homo sapiens 29 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610342&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171350167 494500090 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516542 Cc1cc(nc(n1)N1CCOCC1)N1CCN(CC1)C(=O)c1ccccc1C InChI=1S/C21H27N5O2/c1-16-5-3-4-6-18(16)20(27)25-9-7-24(8-10-25)19-15-17(2)22-21(23-19)26-11-13-28-14-12-26/h3-6,15H,7-14H2,1-2H3 JZFZOTVZZGJFEB-UHFFFAOYSA-N 50610343 CHEMBL5275563 Lysosomal acid glucosylceramidase Homo sapiens 5200 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610343&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047629 494500091 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516543 Cc1cc(nc(n1)N1CCC(F)(F)C1)N1CCN(CC1)C(=O)c1ccccc1C InChI=1S/C21H25F2N5O/c1-15-5-3-4-6-17(15)19(29)27-11-9-26(10-12-27)18-13-16(2)24-20(25-18)28-8-7-21(22,23)14-28/h3-6,13H,7-12,14H2,1-2H3 MMWACXSMRWAKJQ-UHFFFAOYSA-N 50610344 CHEMBL5279401 Lysosomal acid glucosylceramidase Homo sapiens 1400 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610344&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171357414 494500092 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516544 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccccc1 InChI=1S/C20H25N5O/c1-16-15-18(22-20(21-16)25-9-5-6-10-25)23-11-13-24(14-12-23)19(26)17-7-3-2-4-8-17/h2-4,7-8,15H,5-6,9-14H2,1H3 UURILWWMYYNAGX-UHFFFAOYSA-N 50610345 CHEMBL5291224 Lysosomal acid glucosylceramidase Homo sapiens 72 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610345&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53003511 494500093 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516545 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccccc1F InChI=1S/C20H24FN5O/c1-15-14-18(23-20(22-15)26-8-4-5-9-26)24-10-12-25(13-11-24)19(27)16-6-2-3-7-17(16)21/h2-3,6-7,14H,4-5,8-13H2,1H3 HTZNARYRBHXBBG-UHFFFAOYSA-N 50610346 CHEMBL5287219 Lysosomal acid glucosylceramidase Homo sapiens 170 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610346&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047586 494500094 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516546 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccccc1C(F)(F)F InChI=1S/C21H24F3N5O/c1-15-14-18(26-20(25-15)29-8-4-5-9-29)27-10-12-28(13-11-27)19(30)16-6-2-3-7-17(16)21(22,23)24/h2-3,6-7,14H,4-5,8-13H2,1H3 SKGMZKDWWUMKLB-UHFFFAOYSA-N 50610347 CHEMBL5287675 Lysosomal acid glucosylceramidase Homo sapiens 100 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610347&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047594 494500095 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516547 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccccc1Cl InChI=1S/C20H24ClN5O/c1-15-14-18(23-20(22-15)26-8-4-5-9-26)24-10-12-25(13-11-24)19(27)16-6-2-3-7-17(16)21/h2-3,6-7,14H,4-5,8-13H2,1H3 BJGBCMJYFYKSJB-UHFFFAOYSA-N 50610348 CHEMBL5276122 Lysosomal acid glucosylceramidase Homo sapiens 63 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610348&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047589 494500096 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516548 Cc1cccc(c1)C(=O)N1CCN(CC1)c1cc(C)nc(n1)N1CCCC1 InChI=1S/C21H27N5O/c1-16-6-5-7-18(14-16)20(27)25-12-10-24(11-13-25)19-15-17(2)22-21(23-19)26-8-3-4-9-26/h5-7,14-15H,3-4,8-13H2,1-2H3 QAPMGKIOGRLJSX-UHFFFAOYSA-N 50610349 CHEMBL5288960 Lysosomal acid glucosylceramidase Homo sapiens 130 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610349&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53003512 494500097 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516549 Cc1ccc(cc1)C(=O)N1CCN(CC1)c1cc(C)nc(n1)N1CCCC1 InChI=1S/C21H27N5O/c1-16-5-7-18(8-6-16)20(27)25-13-11-24(12-14-25)19-15-17(2)22-21(23-19)26-9-3-4-10-26/h5-8,15H,3-4,9-14H2,1-2H3 DTCZEBQJPWEFDH-UHFFFAOYSA-N 50610350 CHEMBL5276663 Lysosomal acid glucosylceramidase Homo sapiens 70 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610350&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047580 494500098 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516550 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccc(Cl)cc1 InChI=1S/C20H24ClN5O/c1-15-14-18(23-20(22-15)26-8-2-3-9-26)24-10-12-25(13-11-24)19(27)16-4-6-17(21)7-5-16/h4-7,14H,2-3,8-13H2,1H3 WCDCNLWPXUMDRB-UHFFFAOYSA-N 50610351 CHEMBL5272738 Lysosomal acid glucosylceramidase Homo sapiens 40 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047590 494500099 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516551 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C26H29N5O/c1-20-19-24(28-26(27-20)31-13-5-6-14-31)29-15-17-30(18-16-29)25(32)23-11-9-22(10-12-23)21-7-3-2-4-8-21/h2-4,7-12,19H,5-6,13-18H2,1H3 LQVWCHYKQAISGM-UHFFFAOYSA-N 50610352 CHEMBL5290073 Lysosomal acid glucosylceramidase Homo sapiens 58 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610352&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047596 494500100 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516552 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccc(cc1)C(C)(C)C InChI=1S/C24H33N5O/c1-18-17-21(26-23(25-18)29-11-5-6-12-29)27-13-15-28(16-14-27)22(30)19-7-9-20(10-8-19)24(2,3)4/h7-10,17H,5-6,11-16H2,1-4H3 QJZSBJRVAIZDFO-UHFFFAOYSA-N 50610353 CHEMBL5270898 Lysosomal acid glucosylceramidase Homo sapiens 9.6 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610353&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047582 494500101 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516553 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1cnccn1 InChI=1S/C18H23N7O/c1-14-12-16(22-18(21-14)25-6-2-3-7-25)23-8-10-24(11-9-23)17(26)15-13-19-4-5-20-15/h4-5,12-13H,2-3,6-11H2,1H3 DIKJYACQYFWVPZ-UHFFFAOYSA-N 50610354 CHEMBL5268346 Lysosomal acid glucosylceramidase Homo sapiens 5300 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610354&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 121090342 494500102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516554 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccncc1 InChI=1S/C19H24N6O/c1-15-14-17(22-19(21-15)25-8-2-3-9-25)23-10-12-24(13-11-23)18(26)16-4-6-20-7-5-16/h4-7,14H,2-3,8-13H2,1H3 JPCYZCBGEREDDB-UHFFFAOYSA-N 50610355 CHEMBL5266397 Lysosomal acid glucosylceramidase Homo sapiens 6800 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610355&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 122339422 494500103 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516555 CC(=O)N1CCN(CC1)c1cc(C)nc(n1)N1CCCC1 InChI=1S/C15H23N5O/c1-12-11-14(17-15(16-12)20-5-3-4-6-20)19-9-7-18(8-10-19)13(2)21/h11H,3-10H2,1-2H3 NKOKEIILOJADQD-UHFFFAOYSA-N 50610356 CHEMBL5272210 Lysosomal acid glucosylceramidase Homo sapiens 7100 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610356&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 112909430 494500104 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516556 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)C1CCCCC1 InChI=1S/C20H31N5O/c1-16-15-18(22-20(21-16)25-9-5-6-10-25)23-11-13-24(14-12-23)19(26)17-7-3-2-4-8-17/h15,17H,2-14H2,1H3 LZLIVRIAJKIOLI-UHFFFAOYSA-N 50610357 CHEMBL5287823 Lysosomal acid glucosylceramidase Homo sapiens 360 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610357&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047578 494500105 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516557 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)Cc1ccccc1 InChI=1S/C21H27N5O/c1-17-15-19(23-21(22-17)26-9-5-6-10-26)24-11-13-25(14-12-24)20(27)16-18-7-3-2-4-8-18/h2-4,7-8,15H,5-6,9-14,16H2,1H3 NREIJSTYJUQRGH-UHFFFAOYSA-N 50610358 CHEMBL5272952 Lysosomal acid glucosylceramidase Homo sapiens 460 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 121090131 494500106 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516558 Cc1cc(nc(n1)N1CCCC1)N1CCCN(CC1)C(=O)c1ccccc1C InChI=1S/C22H29N5O/c1-17-8-3-4-9-19(17)21(28)26-13-7-12-25(14-15-26)20-16-18(2)23-22(24-20)27-10-5-6-11-27/h3-4,8-9,16H,5-7,10-15H2,1-2H3 BRVYVWJAHLPWGS-UHFFFAOYSA-N 50610359 CHEMBL5289722 Lysosomal acid glucosylceramidase Homo sapiens 1800 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610359&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171350117 494500107 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516559 Cc1cc(nc(n1)N1CCCC1)N1CC2CN(CC2C1)C(=O)c1ccccc1C InChI=1S/C23H29N5O/c1-16-7-3-4-8-20(16)22(29)28-14-18-12-27(13-19(18)15-28)21-11-17(2)24-23(25-21)26-9-5-6-10-26/h3-4,7-8,11,18-19H,5-6,9-10,12-15H2,1-2H3 HIBMCNHFZMRPIU-UHFFFAOYSA-N 50610360 CHEMBL5283330 Lysosomal acid glucosylceramidase Homo sapiens 660 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610360&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171346596 494500108 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516560 Cc1cc(nc(n1)N1CCCC1)N1CC2(CN(C2)C(=O)c2ccccc2C)C1 InChI=1S/C22H27N5O/c1-16-7-3-4-8-18(16)20(28)27-14-22(15-27)12-26(13-22)19-11-17(2)23-21(24-19)25-9-5-6-10-25/h3-4,7-8,11H,5-6,9-10,12-15H2,1-2H3 JMCLCGGZHYKFMS-UHFFFAOYSA-N 50610361 CHEMBL5279069 Lysosomal acid glucosylceramidase Homo sapiens 2100 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610361&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171353700 494500109 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516561 Cc1ccccc1C(=O)N1CCN(CC1)c1ccnc(n1)N1CCCC1 InChI=1S/C20H25N5O/c1-16-6-2-3-7-17(16)19(26)24-14-12-23(13-15-24)18-8-9-21-20(22-18)25-10-4-5-11-25/h2-3,6-9H,4-5,10-15H2,1H3 FQBVZMWMBWEWRW-UHFFFAOYSA-N 50610362 CHEMBL5270914 Lysosomal acid glucosylceramidase Homo sapiens 680 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610362&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 122343681 494500110 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516562 Cl.Cc1ccccc1C(=O)N1CCN(CC1)c1cc(nc(n1)N1CCCC1)C(F)(F)F InChI=1S/C21H24F3N5O.ClH/c1-15-6-2-3-7-16(15)19(30)28-12-10-27(11-13-28)18-14-17(21(22,23)24)25-20(26-18)29-8-4-5-9-29;/h2-3,6-7,14H,4-5,8-13H2,1H3;1H IBXRTZGNYRLEIC-UHFFFAOYSA-N 50610363 CHEMBL5286668 Lysosomal acid glucosylceramidase Homo sapiens >25000 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610363&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171348044 494500111 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516563 Cc1ccccc1C(=O)N1CCN(CC1)c1cc(CO)nc(n1)N1CCCC1 InChI=1S/C21H27N5O2/c1-16-6-2-3-7-18(16)20(28)25-12-10-24(11-13-25)19-14-17(15-27)22-21(23-19)26-8-4-5-9-26/h2-3,6-7,14,27H,4-5,8-13,15H2,1H3 PGSAHPCHKRYDGK-UHFFFAOYSA-N 50610364 CHEMBL5289693 Lysosomal acid glucosylceramidase Homo sapiens 220 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610364&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171349993 494500112 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516564 Cc1ccccc1C(=O)N1CCN(CC1)c1nc(ncc1C)N1CCCC1 InChI=1S/C21H27N5O/c1-16-7-3-4-8-18(16)20(27)25-13-11-24(12-14-25)19-17(2)15-22-21(23-19)26-9-5-6-10-26/h3-4,7-8,15H,5-6,9-14H2,1-2H3 MOZSKHKHOQNLIT-UHFFFAOYSA-N 50610365 CHEMBL5289154 Lysosomal acid glucosylceramidase Homo sapiens 120 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610365&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171350388 494500113 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516565 Cc1ccccc1C(=O)N1CCN(CC1)c1nc(nc(C)c1C)N1CCCC1 InChI=1S/C22H29N5O/c1-16-8-4-5-9-19(16)21(28)26-14-12-25(13-15-26)20-17(2)18(3)23-22(24-20)27-10-6-7-11-27/h4-5,8-9H,6-7,10-15H2,1-3H3 MBJUFRKFBPNZAC-UHFFFAOYSA-N 50610366 CHEMBL5290054 Lysosomal acid glucosylceramidase Homo sapiens 250 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610366&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171358620 494500114 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516566 Cc1ccccc1C(=O)N1CCN(CC1)c1nc(nc2ccccc12)N1CCCC1 InChI=1S/C24H27N5O/c1-18-8-2-3-9-19(18)23(30)28-16-14-27(15-17-28)22-20-10-4-5-11-21(20)25-24(26-22)29-12-6-7-13-29/h2-5,8-11H,6-7,12-17H2,1H3 GIDFXDADENKVMM-UHFFFAOYSA-N 50610367 CHEMBL5280450 Lysosomal acid glucosylceramidase Homo sapiens 79 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610367&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171353073 494500115 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516567 Cc1ccccc1C(=O)N1CCN(CC1)c1nc(nc2CCCc12)N1CCCC1 InChI=1S/C23H29N5O/c1-17-7-2-3-8-18(17)22(29)27-15-13-26(14-16-27)21-19-9-6-10-20(19)24-23(25-21)28-11-4-5-12-28/h2-3,7-8H,4-6,9-16H2,1H3 TYVRECAWEAQFCJ-UHFFFAOYSA-N 50610368 CHEMBL5283935 Lysosomal acid glucosylceramidase Homo sapiens 30 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610368&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171345599 494500116 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516568 CC(C)(C)c1ccc(cc1)C(=O)N1CCN(CC1)c1nc(nc2CCCc12)N1CCCC1 InChI=1S/C26H35N5O/c1-26(2,3)20-11-9-19(10-12-20)24(32)30-17-15-29(16-18-30)23-21-7-6-8-22(21)27-25(28-23)31-13-4-5-14-31/h9-12H,4-8,13-18H2,1-3H3 VLBNHJKZNLFFJY-UHFFFAOYSA-N 50610369 CHEMBL5277174 Lysosomal acid glucosylceramidase Homo sapiens 5.6 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610369&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171355920 494500117 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516569 CC(C)(C)c1ccc(cc1)C(=O)N1CCN(CC1)c1nc(nc2CCCCc12)N1CCCC1 InChI=1S/C27H37N5O/c1-27(2,3)21-12-10-20(11-13-21)25(33)31-18-16-30(17-19-31)24-22-8-4-5-9-23(22)28-26(29-24)32-14-6-7-15-32/h10-13H,4-9,14-19H2,1-3H3 CLFKCBOPZNBSFC-UHFFFAOYSA-N 50610370 CHEMBL5285901 Lysosomal acid glucosylceramidase Homo sapiens 6009 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610370&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171351772 494500118 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516570 Cc1ccccc1C(=O)N1CCN(CC1)c1nc(nc2COCc12)N1CCCC1 InChI=1S/C22H27N5O2/c1-16-6-2-3-7-17(16)21(28)26-12-10-25(11-13-26)20-18-14-29-15-19(18)23-22(24-20)27-8-4-5-9-27/h2-3,6-7H,4-5,8-15H2,1H3 LRHBNRQKRQZDTN-UHFFFAOYSA-N 50610371 CHEMBL5267578 Lysosomal acid glucosylceramidase Homo sapiens 540 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610371&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171350321 494500119 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516571 CC(C)(C)c1ccc(cc1)C(=O)N1CCN(CC1)c1nc(nc2COCc12)N1CCCC1 InChI=1S/C25H33N5O2/c1-25(2,3)19-8-6-18(7-9-19)23(31)29-14-12-28(13-15-29)22-20-16-32-17-21(20)26-24(27-22)30-10-4-5-11-30/h6-9H,4-5,10-17H2,1-3H3 QUZZFQIQBDHXAV-UHFFFAOYSA-N 50610372 CHEMBL5282146 Lysosomal acid glucosylceramidase Homo sapiens 150 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610372&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171357150 494500120 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516572 Cc1ccccc1C(=O)N1CCN(CC1)c1nc(nc2CCOCc12)N1CCCC1 InChI=1S/C23H29N5O2/c1-17-6-2-3-7-18(17)22(29)27-13-11-26(12-14-27)21-19-16-30-15-8-20(19)24-23(25-21)28-9-4-5-10-28/h2-3,6-7H,4-5,8-16H2,1H3 ATXOJURIUGOXQM-UHFFFAOYSA-N 50610373 CHEMBL5285193 Lysosomal acid glucosylceramidase Homo sapiens 410 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610373&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171345023 494500121 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516573 CC(C)c1nc(C)cc(n1)N1CCN(CC1)C(=O)c1cc(nc2n(ncc12)C(C)C)-c1ccccc1 InChI=1S/C28H33N7O/c1-18(2)26-30-20(5)15-25(32-26)33-11-13-34(14-12-33)28(36)22-16-24(21-9-7-6-8-10-21)31-27-23(22)17-29-35(27)19(3)4/h6-10,15-19H,11-14H2,1-5H3 QGFQFCKPIBVGJY-UHFFFAOYSA-N 50610374 CHEMBL4561657 Lysosomal acid glucosylceramidase Homo sapiens 90 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610374&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 16334060 494500122 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516574 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 300 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,8JBO,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516575 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccc(cc1)C(C)(C)C InChI=1S/C24H33N5O/c1-18-17-21(26-23(25-18)29-11-5-6-12-29)27-13-15-28(16-14-27)22(30)19-7-9-20(10-8-19)24(2,3)4/h7-10,17H,5-6,11-16H2,1-4H3 QJZSBJRVAIZDFO-UHFFFAOYSA-N 50610353 CHEMBL5270898 Lysosomal acid glucosylceramidase Homo sapiens 13 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610353&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047582 494500101 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516576 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 390 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,8JBO,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516577 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccc(cc1)C(C)(C)C InChI=1S/C24H33N5O/c1-18-17-21(26-23(25-18)29-11-5-6-12-29)27-13-15-28(16-14-27)22(30)19-7-9-20(10-8-19)24(2,3)4/h7-10,17H,5-6,11-16H2,1-4H3 QJZSBJRVAIZDFO-UHFFFAOYSA-N 50610353 CHEMBL5270898 Lysosomal acid glucosylceramidase Homo sapiens 9700 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610353&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047582 494500101 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516578 CC(C)(C)c1ccc(cc1)C(=O)N1CCN(CC1)c1nc(nc2CCCc12)N1CCCC1 InChI=1S/C26H35N5O/c1-26(2,3)20-11-9-19(10-12-20)24(32)30-17-15-29(16-18-30)23-21-7-6-8-22(21)27-25(28-23)31-13-4-5-14-31/h9-12H,4-8,13-18H2,1-3H3 VLBNHJKZNLFFJY-UHFFFAOYSA-N 50610369 CHEMBL5277174 Lysosomal acid glucosylceramidase Homo sapiens 4200 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610369&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171355920 494500117 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516579 CC(C)(C)c1ccc(cc1)C(=O)N1CCN(CC1)c1nc(nc2CCCCc12)N1CCCC1 InChI=1S/C27H37N5O/c1-27(2,3)21-12-10-20(11-13-21)25(33)31-18-16-30(17-19-31)24-22-8-4-5-9-23(22)28-26(29-24)32-14-6-7-15-32/h10-13H,4-9,14-19H2,1-3H3 CLFKCBOPZNBSFC-UHFFFAOYSA-N 50610370 CHEMBL5285901 Lysosomal acid glucosylceramidase Homo sapiens 5200 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610370&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171351772 494500118 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516580 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 230 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,8JBO,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516581 Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccc(cc1)C(C)(C)C InChI=1S/C24H33N5O/c1-18-17-21(26-23(25-18)29-11-5-6-12-29)27-13-15-28(16-14-27)22(30)19-7-9-20(10-8-19)24(2,3)4/h7-10,17H,5-6,11-16H2,1-4H3 QJZSBJRVAIZDFO-UHFFFAOYSA-N 50610353 CHEMBL5270898 Lysosomal acid glucosylceramidase Homo sapiens 27 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610353&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 53047582 494500101 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516582 CC(C)(C)c1ccc(cc1)C(=O)N1CCN(CC1)c1nc(nc2CCCc12)N1CCCC1 InChI=1S/C26H35N5O/c1-26(2,3)20-11-9-19(10-12-20)24(32)30-17-15-29(16-18-30)23-21-7-6-8-22(21)27-25(28-23)31-13-4-5-14-31/h9-12H,4-8,13-18H2,1-3H3 VLBNHJKZNLFFJY-UHFFFAOYSA-N 50610369 CHEMBL5277174 Lysosomal acid glucosylceramidase Homo sapiens 3.7 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610369&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171355920 494500117 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516583 CC(C)(C)c1ccc(cc1)C(=O)N1CCN(CC1)c1nc(nc2CCCCc12)N1CCCC1 InChI=1S/C27H37N5O/c1-27(2,3)21-12-10-20(11-13-21)25(33)31-18-16-30(17-19-31)24-22-8-4-5-9-23(22)28-26(29-24)32-14-6-7-15-32/h10-13H,4-9,14-19H2,1-3H3 CLFKCBOPZNBSFC-UHFFFAOYSA-N 50610370 CHEMBL5285901 Lysosomal acid glucosylceramidase Homo sapiens 6.5 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610370&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 171351772 494500118 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51516584 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 410 ChEMBL 10.7270/Q2MP57HM 36640928 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,8JBO,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 2WKL,5LVX,6T13 Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51541970 OC[C@H]1NC[C@@H](O)[C@@H]1O InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5?/m1/s1 OQEBIHBLFRADNM-ZZKAVYKESA-N 50016703 2-Hydroxymethyl-pyrrolidine-3,4-diol::BDBM50031485::CHEMBL80254::Imino-D-Arabinitol Lysosomal acid glucosylceramidase Homo sapiens 340000 ChEMBL 10.1021/acs.jmedchem.3c00637 10.7270/Q2KH0SQ0 37314161 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016703&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1AB 2G9Q,6LGD 451991 103928072 CHEMBL305131CHEMBL80254 ZINC26187408 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51541971 OC[C@@H]1[C@@H](O)[C@H](O)CN1CCCc1ccccc1 InChI=1S/C14H21NO3/c16-10-12-14(18)13(17)9-15(12)8-4-7-11-5-2-1-3-6-11/h1-3,5-6,12-14,16-18H,4,7-10H2/t12-,13-,14-/m1/s1 JLZUOZINRJPKSK-MGPQQGTHSA-N 50620318 CHEMBL5434032 Lysosomal acid glucosylceramidase Homo sapiens 489000 ChEMBL 10.1021/acs.jmedchem.3c00637 10.7270/Q2KH0SQ0 37314161 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620318&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51541972 OC[C@@H]1[C@@H](O)[C@H](O)CN1CCCCc1ccccc1 InChI=1S/C15H23NO3/c17-11-13-15(19)14(18)10-16(13)9-5-4-8-12-6-2-1-3-7-12/h1-3,6-7,13-15,17-19H,4-5,8-11H2/t13-,14-,15-/m1/s1 NNBLQAJWVCYXDM-RBSFLKMASA-N 50620319 CHEMBL5398090 Lysosomal acid glucosylceramidase Homo sapiens 311000 ChEMBL 10.1021/acs.jmedchem.3c00637 10.7270/Q2KH0SQ0 37314161 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620319&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51541973 OC[C@@H]1[C@@H](O)[C@H](O)CN1CCCCCc1ccccc1 InChI=1S/C16H25NO3/c18-12-14-16(20)15(19)11-17(14)10-6-2-5-9-13-7-3-1-4-8-13/h1,3-4,7-8,14-16,18-20H,2,5-6,9-12H2/t14-,15-,16-/m1/s1 PSNXCVDXVFRQFK-BZUAXINKSA-N 50620320 CHEMBL5417186 Lysosomal acid glucosylceramidase Homo sapiens 53000 ChEMBL 10.1021/acs.jmedchem.3c00637 10.7270/Q2KH0SQ0 37314161 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620320&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51541974 CCCCCCCN1C[C@@H](O)[C@H](O)[C@H]1CO InChI=1S/C12H25NO3/c1-2-3-4-5-6-7-13-8-11(15)12(16)10(13)9-14/h10-12,14-16H,2-9H2,1H3/t10-,11-,12-/m1/s1 FNUQGLQNLIKWHQ-IJLUTSLNSA-N 50620315 CHEMBL5427599 Lysosomal acid glucosylceramidase Homo sapiens 255000 ChEMBL 10.1021/acs.jmedchem.3c00637 10.7270/Q2KH0SQ0 37314161 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620315&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51541975 OC[C@H]1[C@H](O)[C@@H](O)CN1CCCCc1ccccc1 InChI=1S/C15H23NO3/c17-11-13-15(19)14(18)10-16(13)9-5-4-8-12-6-2-1-3-7-12/h1-3,6-7,13-15,17-19H,4-5,8-11H2/t13-,14-,15-/m0/s1 NNBLQAJWVCYXDM-KKUMJFAQSA-N 50620322 CHEMBL5419404 Lysosomal acid glucosylceramidase Homo sapiens 398000 ChEMBL 10.1021/acs.jmedchem.3c00637 10.7270/Q2KH0SQ0 37314161 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620322&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51541976 CCCCN1C[C@H](O)[C@@H](O)[C@@H]1CO InChI=1S/C9H19NO3/c1-2-3-4-10-5-8(12)9(13)7(10)6-11/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m0/s1 AORXTDSJOOFVRB-CIUDSAMLSA-N 50399651 CHEMBL2177696 Lysosomal acid glucosylceramidase Homo sapiens 650000 ChEMBL 10.1021/acs.jmedchem.3c00637 10.7270/Q2KH0SQ0 37314161 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399651&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 10058315 163348675 CHEMBL2177696 ZINC95578102 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51541977 CCCCCCCN1C[C@H](O)[C@@H](O)[C@@H]1CO InChI=1S/C12H25NO3/c1-2-3-4-5-6-7-13-8-11(15)12(16)10(13)9-14/h10-12,14-16H,2-9H2,1H3/t10-,11-,12-/m0/s1 FNUQGLQNLIKWHQ-SRVKXCTJSA-N 50620316 CHEMBL5429141 Lysosomal acid glucosylceramidase Homo sapiens 650000 ChEMBL 10.1021/acs.jmedchem.3c00637 10.7270/Q2KH0SQ0 37314161 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620316&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51541978 CCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C12H25NO3/c1-2-3-4-5-6-7-9-11(15)12(16)10(8-14)13-9/h9-16H,2-8H2,1H3/t9-,10-,11-,12-/m1/s1 ZHCDSIQDIBIMCV-DDHJBXDOSA-N 50598375 CHEMBL5185978 Lysosomal acid glucosylceramidase Homo sapiens 38000 ChEMBL 10.1021/acs.jmedchem.3c00637 10.7270/Q2KH0SQ0 37314161 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598375&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 168282228 482609227 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51541979 CCCCCCC[C@@H]1N[C@@H](CO)[C@H](O)[C@H]1O InChI=1S/C12H25NO3/c1-2-3-4-5-6-7-9-11(15)12(16)10(8-14)13-9/h9-16H,2-8H2,1H3/t9-,10-,11-,12-/m0/s1 ZHCDSIQDIBIMCV-BJDJZHNGSA-N 50333458 (2S,3S,4S,5S)-2-heptyl-5-(hydroxymethyl)pyrrolidine-3,4-diol::CHEMBL1641743 Lysosomal acid glucosylceramidase Homo sapiens 124000 ChEMBL 10.1021/acs.jmedchem.3c00637 10.7270/Q2KH0SQ0 37314161 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333458&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 52939731 125083560 CHEMBL1641743 ZINC66252376 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51541980 CCCCCCCCCCCCC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C18H37NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-17(21)18(22)16(14-20)19-15/h15-22H,2-14H2,1H3/t15-,16-,17-,18-/m1/s1 UGACFOJZAZEING-BRSBDYLESA-N 50598381 CHEMBL5172851 Lysosomal acid glucosylceramidase Homo sapiens 770 ChEMBL 10.1021/acs.jmedchem.3c00637 10.7270/Q2KH0SQ0 37314161 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598381&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 132557843 482609233 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51541981 OC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1 PFYHYHZGDNWFIF-KVTDHHQDSA-N 50031481 (2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol::2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine::2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine::CHEMBL312653 Lysosomal acid glucosylceramidase Homo sapiens 171000 ChEMBL 10.1021/acs.jmedchem.3c00637 10.7270/Q2KH0SQ0 37314161 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031481&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search DQQ 2AEY 124702 103940112 CHEMBL312653 C10143 ZINC01492230 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540042 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1 InChI=1S/C19H18N6O/c1-11-15-18(26)17(25-14-10-6-5-9-13(14)22-24-25)16(20-19(15)23-21-11)12-7-3-2-4-8-12/h2-10,16-18,26H,1H3,(H2,20,21,23)/t16-,17-,18-/m1/s1 OPZLYEPKPOCRPI-KZNAEPCWSA-N 50619337 CHEMBL5406998 Lysosomal acid glucosylceramidase Homo sapiens 1400 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619337&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540043 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1C InChI=1S/C20H20N6O/c1-11-7-3-4-8-13(11)17-18(19(27)16-12(2)22-24-20(16)21-17)26-15-10-6-5-9-14(15)23-25-26/h3-10,17-19,27H,1-2H3,(H2,21,22,24)/t17-,18-,19-/m1/s1 CEPIINMRMLYIJO-GUDVDZBRSA-N 50619338 CHEMBL5417555 Lysosomal acid glucosylceramidase Homo sapiens 1900 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619338&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540044 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1cccc(C)c1 InChI=1S/C20H20N6O/c1-11-6-5-7-13(10-11)17-18(19(27)16-12(2)22-24-20(16)21-17)26-15-9-4-3-8-14(15)23-25-26/h3-10,17-19,27H,1-2H3,(H2,21,22,24)/t17-,18-,19-/m1/s1 DMDVIXRFMSMGCW-GUDVDZBRSA-N 50619339 CHEMBL5395546 Lysosomal acid glucosylceramidase Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619339&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540045 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccc(C)cc1 InChI=1S/C20H20N6O/c1-11-7-9-13(10-8-11)17-18(19(27)16-12(2)22-24-20(16)21-17)26-15-6-4-3-5-14(15)23-25-26/h3-10,17-19,27H,1-2H3,(H2,21,22,24)/t17-,18-,19-/m1/s1 FDRANPXITJAFLS-GUDVDZBRSA-N 50619340 CHEMBL5401583 Lysosomal acid glucosylceramidase Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619340&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540046 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1F InChI=1S/C19H17FN6O/c1-10-15-18(27)17(26-14-9-5-4-8-13(14)23-25-26)16(21-19(15)24-22-10)11-6-2-3-7-12(11)20/h2-9,16-18,27H,1H3,(H2,21,22,24)/t16-,17-,18-/m1/s1 CGOMAGNHDVQWRL-KZNAEPCWSA-N 50619341 CHEMBL5440774 Lysosomal acid glucosylceramidase Homo sapiens 970 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619341&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540047 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1cccc(F)c1 InChI=1S/C19H17FN6O/c1-10-15-18(27)17(26-14-8-3-2-7-13(14)23-25-26)16(21-19(15)24-22-10)11-5-4-6-12(20)9-11/h2-9,16-18,27H,1H3,(H2,21,22,24)/t16-,17-,18-/m1/s1 SGTJWUOEIWYBIE-KZNAEPCWSA-N 50619342 CHEMBL5414223 Lysosomal acid glucosylceramidase Homo sapiens 1200 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619342&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540048 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccc(F)cc1 InChI=1S/C19H17FN6O/c1-10-15-18(27)17(26-14-5-3-2-4-13(14)23-25-26)16(21-19(15)24-22-10)11-6-8-12(20)9-7-11/h2-9,16-18,27H,1H3,(H2,21,22,24)/t16-,17-,18-/m1/s1 HJPGZDFKFSGKME-KZNAEPCWSA-N 50619343 CHEMBL5420536 Lysosomal acid glucosylceramidase Homo sapiens 2200 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619343&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540049 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1Cl InChI=1S/C19H17ClN6O/c1-10-15-18(27)17(26-14-9-5-4-8-13(14)23-25-26)16(21-19(15)24-22-10)11-6-2-3-7-12(11)20/h2-9,16-18,27H,1H3,(H2,21,22,24)/t16-,17-,18-/m1/s1 QHUGHYRRDMQZRA-KZNAEPCWSA-N 50619344 CHEMBL5404112 Lysosomal acid glucosylceramidase Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619344&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540050 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1Br InChI=1S/C19H17BrN6O/c1-10-15-18(27)17(26-14-9-5-4-8-13(14)23-25-26)16(21-19(15)24-22-10)11-6-2-3-7-12(11)20/h2-9,16-18,27H,1H3,(H2,21,22,24)/t16-,17-,18-/m1/s1 VQNUMYJMXZGIEH-KZNAEPCWSA-N 50619345 CHEMBL5396013 Lysosomal acid glucosylceramidase Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619345&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540051 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1C(F)(F)F InChI=1S/C20H17F3N6O/c1-10-15-18(30)17(29-14-9-5-4-8-13(14)26-28-29)16(24-19(15)27-25-10)11-6-2-3-7-12(11)20(21,22)23/h2-9,16-18,30H,1H3,(H2,24,25,27)/t16-,17-,18-/m1/s1 WQXWBNBDLKFNNM-KZNAEPCWSA-N 50619346 CHEMBL5395260 Lysosomal acid glucosylceramidase Homo sapiens 470 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619346&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540052 COc1ccccc1[C@H]1Nc2[nH]nc(C)c2[C@@H](O)[C@@H]1n1nnc2ccccc12 InChI=1S/C20H20N6O2/c1-11-16-19(27)18(26-14-9-5-4-8-13(14)23-25-26)17(21-20(16)24-22-11)12-7-3-6-10-15(12)28-2/h3-10,17-19,27H,1-2H3,(H2,21,22,24)/t17-,18-,19-/m1/s1 LJLRRWYJKVADTB-GUDVDZBRSA-N 50619347 CHEMBL5410068 Lysosomal acid glucosylceramidase Homo sapiens 3300 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619347&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540053 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1cccc(C)c1Cl InChI=1S/C20H19ClN6O/c1-10-6-5-7-12(16(10)21)17-18(19(28)15-11(2)23-25-20(15)22-17)27-14-9-4-3-8-13(14)24-26-27/h3-9,17-19,28H,1-2H3,(H2,22,23,25)/t17-,18-,19-/m1/s1 ZQOMZGJEYNVFGV-GUDVDZBRSA-N 50619348 CHEMBL5410576 Lysosomal acid glucosylceramidase Homo sapiens 150 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619348&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540054 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1cccc(F)c1Cl InChI=1S/C19H16ClFN6O/c1-9-14-18(28)17(27-13-8-3-2-7-12(13)24-26-27)16(22-19(14)25-23-9)10-5-4-6-11(21)15(10)20/h2-8,16-18,28H,1H3,(H2,22,23,25)/t16-,17-,18-/m1/s1 NWBJIRDKGJBVFG-KZNAEPCWSA-N 50619349 CHEMBL5425701 Lysosomal acid glucosylceramidase Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619349&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540055 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1cccc(Cl)c1Cl InChI=1S/C19H16Cl2N6O/c1-9-14-18(28)17(27-13-8-3-2-7-12(13)24-26-27)16(22-19(14)25-23-9)10-5-4-6-11(20)15(10)21/h2-8,16-18,28H,1H3,(H2,22,23,25)/t16-,17-,18-/m1/s1 YUPUUOXKXDNFGQ-KZNAEPCWSA-N 50619350 CHEMBL5401622 Lysosomal acid glucosylceramidase Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619350&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540056 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccc(Cl)cc1Cl InChI=1S/C19H16Cl2N6O/c1-9-15-18(28)17(27-14-5-3-2-4-13(14)24-26-27)16(22-19(15)25-23-9)11-7-6-10(20)8-12(11)21/h2-8,16-18,28H,1H3,(H2,22,23,25)/t16-,17-,18-/m1/s1 KBTWPVMQHGBLNR-KZNAEPCWSA-N 50619351 CHEMBL5413426 Lysosomal acid glucosylceramidase Homo sapiens 740 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619351&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540057 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1cc(Cl)ccc1Cl InChI=1S/C19H16Cl2N6O/c1-9-15-18(28)17(27-14-5-3-2-4-13(14)24-26-27)16(22-19(15)25-23-9)11-8-10(20)6-7-12(11)21/h2-8,16-18,28H,1H3,(H2,22,23,25)/t16-,17-,18-/m1/s1 LUUKLALVSBIUGJ-KZNAEPCWSA-N 50619352 CHEMBL5422651 Lysosomal acid glucosylceramidase Homo sapiens 720 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619352&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540058 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1 InChI=1S/C19H18N6O/c1-11-15-18(26)17(25-14-10-6-5-9-13(14)22-24-25)16(20-19(15)23-21-11)12-7-3-2-4-8-12/h2-10,16-18,26H,1H3,(H2,20,21,23)/t16-,17-,18-/m1/s1 OPZLYEPKPOCRPI-KZNAEPCWSA-N 50619337 CHEMBL5406998 Lysosomal acid glucosylceramidase Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619337&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540059 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1Cl InChI=1S/C19H17ClN6O/c1-10-15-18(27)17(26-14-9-5-4-8-13(14)23-25-26)16(21-19(15)24-22-10)11-6-2-3-7-12(11)20/h2-9,16-18,27H,1H3,(H2,21,22,24)/t16-,17-,18-/m1/s1 QHUGHYRRDMQZRA-KZNAEPCWSA-N 50619344 CHEMBL5404112 Lysosomal acid glucosylceramidase Homo sapiens 76 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619344&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540060 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1Br InChI=1S/C19H17BrN6O/c1-10-15-18(27)17(26-14-9-5-4-8-13(14)23-25-26)16(21-19(15)24-22-10)11-6-2-3-7-12(11)20/h2-9,16-18,27H,1H3,(H2,21,22,24)/t16-,17-,18-/m1/s1 VQNUMYJMXZGIEH-KZNAEPCWSA-N 50619345 CHEMBL5396013 Lysosomal acid glucosylceramidase Homo sapiens 86 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619345&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540061 Cc1n[nH]c2N[C@H](C3CCCC3)[C@H]([C@H](O)c12)n1nnc2ccccc12 InChI=1S/C18H22N6O/c1-10-14-17(25)16(24-13-9-5-4-8-12(13)21-23-24)15(11-6-2-3-7-11)19-18(14)22-20-10/h4-5,8-9,11,15-17,25H,2-3,6-7H2,1H3,(H2,19,20,22)/t15-,16-,17-/m1/s1 DFYLHXOTWAOYNI-BRWVUGGUSA-N 50619353 CHEMBL5426634 Lysosomal acid glucosylceramidase Homo sapiens 1900 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619353&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540062 Cc1n[nH]c2N[C@H](C3CCCCC3)[C@H]([C@H](O)c12)n1nnc2ccccc12 InChI=1S/C19H24N6O/c1-11-15-18(26)17(25-14-10-6-5-9-13(14)22-24-25)16(20-19(15)23-21-11)12-7-3-2-4-8-12/h5-6,9-10,12,16-18,26H,2-4,7-8H2,1H3,(H2,20,21,23)/t16-,17-,18-/m1/s1 OLIATESFKHNVTC-KZNAEPCWSA-N 50619354 CHEMBL5408859 Lysosomal acid glucosylceramidase Homo sapiens 370 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619354&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540063 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)C1CCCCCC1 InChI=1S/C20H26N6O/c1-12-16-19(27)18(26-15-11-7-6-10-14(15)23-25-26)17(21-20(16)24-22-12)13-8-4-2-3-5-9-13/h6-7,10-11,13,17-19,27H,2-5,8-9H2,1H3,(H2,21,22,24)/t17-,18-,19-/m1/s1 UXDOPXOGNMKKNM-GUDVDZBRSA-N 50619355 CHEMBL5404283 Lysosomal acid glucosylceramidase Homo sapiens 230 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619355&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540064 Cc1n[nH]c2N[C@H](C3CCOCC3)[C@H]([C@H](O)c12)n1nnc2ccccc12 InChI=1S/C18H22N6O2/c1-10-14-17(25)16(24-13-5-3-2-4-12(13)21-23-24)15(19-18(14)22-20-10)11-6-8-26-9-7-11/h2-5,11,15-17,25H,6-9H2,1H3,(H2,19,20,22)/t15-,16-,17-/m1/s1 ODZVWCDIUYLQIL-BRWVUGGUSA-N 50619356 CHEMBL5413060 Lysosomal acid glucosylceramidase Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619356&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540065 O[C@H]1[C@@H]([C@H](Nc2[nH]ncc12)c1ccccc1)n1nnc2ccccc12 InChI=1S/C18H16N6O/c25-17-12-10-19-22-18(12)20-15(11-6-2-1-3-7-11)16(17)24-14-9-5-4-8-13(14)21-23-24/h1-10,15-17,25H,(H2,19,20,22)/t15-,16-,17-/m1/s1 BKHTUDNXNLAXLN-BRWVUGGUSA-N 50619357 CHEMBL5402801 Lysosomal acid glucosylceramidase Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619357&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540066 CCc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1Cl InChI=1S/C20H19ClN6O/c1-2-13-16-19(28)18(27-15-10-6-5-9-14(15)24-26-27)17(22-20(16)25-23-13)11-7-3-4-8-12(11)21/h3-10,17-19,28H,2H2,1H3,(H2,22,23,25)/t17-,18-,19-/m1/s1 KCPFJJXYKLGFFH-GUDVDZBRSA-N 50619358 CHEMBL5436521 Lysosomal acid glucosylceramidase Homo sapiens 480 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619358&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540067 O[C@H]1[C@@H]([C@H](Nc2[nH]nc(C3CC3)c12)c1ccccc1Cl)n1nnc2ccccc12 InChI=1S/C21H19ClN6O/c22-13-6-2-1-5-12(13)18-19(28-15-8-4-3-7-14(15)24-27-28)20(29)16-17(11-9-10-11)25-26-21(16)23-18/h1-8,11,18-20,29H,9-10H2,(H2,23,25,26)/t18-,19-,20-/m1/s1 MPMKBQUANORLNL-VAMGGRTRSA-N 50619359 CHEMBL5396941 Lysosomal acid glucosylceramidase Homo sapiens 83 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619359&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540068 CC(C)(C)c1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1Cl InChI=1S/C22H23ClN6O/c1-22(2,3)20-16-19(30)18(29-15-11-7-6-10-14(15)25-28-29)17(24-21(16)27-26-20)12-8-4-5-9-13(12)23/h4-11,17-19,30H,1-3H3,(H2,24,26,27)/t17-,18-,19-/m1/s1 FZJUTQQVRVQVMO-GUDVDZBRSA-N 50619360 CHEMBL5421765 Lysosomal acid glucosylceramidase Homo sapiens 7400 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619360&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540069 O[C@H]1[C@@H]([C@H](Nc2cnccc12)c1ccccc1Cl)n1nnc2ccccc12 InChI=1S/C20H16ClN5O/c21-14-6-2-1-5-12(14)18-19(20(27)13-9-10-22-11-16(13)23-18)26-17-8-4-3-7-15(17)24-25-26/h1-11,18-20,23,27H/t18-,19-,20-/m1/s1 KQXDAEYDBNIDOE-VAMGGRTRSA-N 50619361 CHEMBL5440207 Lysosomal acid glucosylceramidase Homo sapiens 570 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619361&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540070 O[C@H]1[C@@H]([C@H](Nc2ccncc12)c1ccccc1Cl)n1nnc2ccccc12 InChI=1S/C20H16ClN5O/c21-14-6-2-1-5-12(14)18-19(20(27)13-11-22-10-9-15(13)23-18)26-17-8-4-3-7-16(17)24-25-26/h1-11,18-20,23,27H/t18-,19-,20-/m1/s1 DQFNVIXRSAVODA-VAMGGRTRSA-N 50619362 CHEMBL5403195 Lysosomal acid glucosylceramidase Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619362&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540071 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 300 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,8JBO,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540072 Cc1cc2N[C@@H]([C@H](C(O)n2n1)n1nnc2ccccc12)c1ccccc1 InChI=1S/C19H18N6O/c1-12-11-16-20-17(13-7-3-2-4-8-13)18(19(26)25(16)22-12)24-15-10-6-5-9-14(15)21-23-24/h2-11,17-20,26H,1H3/t17-,18-,19?/m1/s1 QYIMBGUTTGZXCZ-PWCSWUJKSA-N 50619363 CHEMBL5429998 Lysosomal acid glucosylceramidase Homo sapiens 5600 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619363&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540073 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1 InChI=1S/C19H18N6O/c1-11-15-18(26)17(25-14-10-6-5-9-13(14)22-24-25)16(20-19(15)23-21-11)12-7-3-2-4-8-12/h2-10,16-18,26H,1H3,(H2,20,21,23)/t16-,17-,18-/m1/s1 OPZLYEPKPOCRPI-KZNAEPCWSA-N 50619337 CHEMBL5406998 Lysosomal acid glucosylceramidase Homo sapiens 3200 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619337&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540074 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1C(F)(F)F InChI=1S/C20H17F3N6O/c1-10-15-18(30)17(29-14-9-5-4-8-13(14)26-28-29)16(24-19(15)27-25-10)11-6-2-3-7-12(11)20(21,22)23/h2-9,16-18,30H,1H3,(H2,24,25,27)/t16-,17-,18-/m1/s1 WQXWBNBDLKFNNM-KZNAEPCWSA-N 50619346 CHEMBL5395260 Lysosomal acid glucosylceramidase Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619346&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540075 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1F InChI=1S/C19H17FN6O/c1-10-15-18(27)17(26-14-9-5-4-8-13(14)23-25-26)16(21-19(15)24-22-10)11-6-2-3-7-12(11)20/h2-9,16-18,27H,1H3,(H2,21,22,24)/t16-,17-,18-/m1/s1 CGOMAGNHDVQWRL-KZNAEPCWSA-N 50619341 CHEMBL5440774 Lysosomal acid glucosylceramidase Homo sapiens 1800 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619341&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540076 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1C InChI=1S/C20H20N6O/c1-11-7-3-4-8-13(11)17-18(19(27)16-12(2)22-24-20(16)21-17)26-15-10-6-5-9-14(15)23-25-26/h3-10,17-19,27H,1-2H3,(H2,21,22,24)/t17-,18-,19-/m1/s1 CEPIINMRMLYIJO-GUDVDZBRSA-N 50619338 CHEMBL5417555 Lysosomal acid glucosylceramidase Homo sapiens 4600 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619338&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540077 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1Cl InChI=1S/C19H17ClN6O/c1-10-15-18(27)17(26-14-9-5-4-8-13(14)23-25-26)16(21-19(15)24-22-10)11-6-2-3-7-12(11)20/h2-9,16-18,27H,1H3,(H2,21,22,24)/t16-,17-,18-/m1/s1 QHUGHYRRDMQZRA-KZNAEPCWSA-N 50619344 CHEMBL5404112 Lysosomal acid glucosylceramidase Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619344&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540078 Cc1n[nH]c2N[C@@H]([C@H]([C@H](O)c12)n1nnc2ccccc12)c1ccccc1Br InChI=1S/C19H17BrN6O/c1-10-15-18(27)17(26-14-9-5-4-8-13(14)23-25-26)16(21-19(15)24-22-10)11-6-2-3-7-12(11)20/h2-9,16-18,27H,1H3,(H2,21,22,24)/t16-,17-,18-/m1/s1 VQNUMYJMXZGIEH-KZNAEPCWSA-N 50619345 CHEMBL5396013 Lysosomal acid glucosylceramidase Homo sapiens 330 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619345&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540079 Cc1n[nH]c2N[C@H](C3CCCCC3)[C@H]([C@H](O)c12)n1nnc2ccccc12 InChI=1S/C19H24N6O/c1-11-15-18(26)17(25-14-10-6-5-9-13(14)22-24-25)16(20-19(15)23-21-11)12-7-3-2-4-8-12/h5-6,9-10,12,16-18,26H,2-4,7-8H2,1H3,(H2,20,21,23)/t16-,17-,18-/m1/s1 OLIATESFKHNVTC-KZNAEPCWSA-N 50619354 CHEMBL5408859 Lysosomal acid glucosylceramidase Homo sapiens 650 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619354&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540080 O[C@H]1[C@@H]([C@H](Nc2[nH]nc(C3CC3)c12)c1ccccc1Cl)n1nnc2ccccc12 InChI=1S/C21H19ClN6O/c22-13-6-2-1-5-12(13)18-19(28-15-8-4-3-7-14(15)24-27-28)20(29)16-17(11-9-10-11)25-26-21(16)23-18/h1-8,11,18-20,29H,9-10H2,(H2,23,25,26)/t18-,19-,20-/m1/s1 MPMKBQUANORLNL-VAMGGRTRSA-N 50619359 CHEMBL5396941 Lysosomal acid glucosylceramidase Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619359&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540081 O[C@H]1[C@@H]([C@H](Nc2cnccc12)c1ccccc1Cl)n1nnc2ccccc12 InChI=1S/C20H16ClN5O/c21-14-6-2-1-5-12(14)18-19(20(27)13-9-10-22-11-16(13)23-18)26-17-8-4-3-7-15(17)24-25-26/h1-11,18-20,23,27H/t18-,19-,20-/m1/s1 KQXDAEYDBNIDOE-VAMGGRTRSA-N 50619361 CHEMBL5440207 Lysosomal acid glucosylceramidase Homo sapiens 1800 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619361&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8 51540082 OC[C@H]1CNC[C@@H](O)[C@@H]1O InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1 QPYJXFZUIJOGNX-HSUXUTPPSA-N 50182801 (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8::(3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol::5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE::AFEGOSTAT TARTRATE::CHEMBL206468::D-Isofagomine::US10081601, Example 1.1::US9796680, Example Table2.1::isofagomine Lysosomal acid glucosylceramidase Homo sapiens 410 ChEMBL 10.1016/j.bmcl.2023.129531 10.7270/Q2MS3Z4N 37866711 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50182801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1913&target=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50182801&enzyme=Lysosomal+acid+glucosylceramidase&column=ki&startPg=0&Increment=50&submit=Search IFM 4D4D,1UP2,3GXF,1OCN,1OCQ,6ZFA,6ZJ6,4V27,3QFY,2G9V,5H41,6ZDL,4ZOA,1OIF,4IIC,8JBO,3WH8,4RE4,4AD4,4AD2,2NSX,4KTR,4UTF,4CD7,4CD6,4CD4,7LOU 447607 104067416 CHEMBL206468 DB04545 ZINC03813668 1 MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ 9FDI,9FB2,9FAZ,9FAY,9FAL,9FAD,9FA6,9FA3,6T13,9F9Z,8AX3,8AWR,8AWK,7NWV,6Z3I,6YTR,6TN1,6TJQ,6TJK,5LVX,2WKL Lysosomal acid glucosylceramidase GBA1_HUMAN P04062 A8K796 B7Z5G2 B7Z6S1 J3KQG4 J3KQK9 Q16545 Q4VX22 Q6I9R6 Q9UMJ8