BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1531959 CC(=O)Nc4cc(c3cc(c2cc(NC(=O)c1ccnc(C(F)(F)F)c1)ccc2C)cc(OCCO)n3)ccn4 InChI=1S/C28H24F3N5O4/c1-16-3-4-21(35-27(39)19-6-7-32-24(12-19)28(29,30)31)15-22(16)20-11-23(36-26(14-20)40-10-9-37)18-5-8-33-25(13-18)34-17(2)38/h3-8,11-15,37H,9-10H2,1-2H3,(H,35,39)(H,33,34,38) ZBAPHPULWRWZCA-UHFFFAOYSA-N 744720 US12319655, Example 1 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=744720 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=744720&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930038 518817459 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1531963 CC(=O)Nc4cc(c3cc(c2cc(NC(=O)c1ccnc(C(F)(F)F)c1)c(F)cc2C)ccn3)ccn4 InChI=1S/C26H19F4N5O2/c1-14-9-20(27)22(35-25(37)18-5-7-32-23(11-18)26(28,29)30)13-19(14)16-3-6-31-21(10-16)17-4-8-33-24(12-17)34-15(2)36/h3-13H,1-2H3,(H,35,37)(H,33,34,36) IKVMBCWGNAZDIF-UHFFFAOYSA-N 744727 US12319655, Example 2 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=744727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=744727&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930204 518817466 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1531967 CNC(=O)c4cc(c3cc(c2cc(NC(=O)c1ccnc(C(F)(F)F)c1)c(F)cc2C)ccn3)ccn4 InChI=1S/C26H19F4N5O2/c1-14-9-19(27)21(35-24(36)17-5-8-34-23(12-17)26(28,29)30)13-18(14)15-3-6-32-20(10-15)16-4-7-33-22(11-16)25(37)31-2/h3-13H,1-2H3,(H,31,37)(H,35,36) SOUUSQQXHJPACM-UHFFFAOYSA-N 744754 US12319655, Example 3 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=744754 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=744754&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170103058 518817491 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1531971 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)c(F)cc3C)cc(C)n2)ccn1 InChI=1S/C27H21F4N5O2/c1-14-8-21(28)23(36-26(38)18-5-6-32-24(11-18)27(29,30)31)13-20(14)19-9-15(2)34-22(10-19)17-4-7-33-25(12-17)35-16(3)37/h4-13H,1-3H3,(H,36,38)(H,33,35,37) MSGRHUAOZGIEBH-UHFFFAOYSA-N 745506 US12319655, Example 4 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745506 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745506&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930329 518818243 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1531975 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)cc(C)n2)ccn1 InChI=1S/C27H22F3N5O2/c1-15-4-5-21(35-26(37)19-7-8-31-24(12-19)27(28,29)30)14-22(15)20-10-16(2)33-23(11-20)18-6-9-32-25(13-18)34-17(3)36/h4-14H,1-3H3,(H,35,37)(H,32,34,36) RVEDJRNHONIJJB-UHFFFAOYSA-N 745511 US12319655, Example 5 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745511 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745511&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930141 518818248 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1531979 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)ccn2)ccn1 InChI=1S/C26H20F3N5O2/c1-15-3-4-20(34-25(36)19-7-9-31-23(12-19)26(27,28)29)14-21(15)17-5-8-30-22(11-17)18-6-10-32-24(13-18)33-16(2)35/h3-14H,1-2H3,(H,34,36)(H,32,33,35) KIJQBTFLBJFOKV-UHFFFAOYSA-N 745520 US12319655, Example 6 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745520 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745520&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930564 518818257 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1531983 Cc1cc(F)c(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)CN(C)C)c2)c1 InChI=1S/C28H24F4N6O2/c1-16-10-21(29)23(36-27(40)19-6-8-34-24(12-19)28(30,31)32)14-20(16)17-4-7-33-22(11-17)18-5-9-35-25(13-18)37-26(39)15-38(2)3/h4-14H,15H2,1-3H3,(H,36,40)(H,35,37,39) UVBZWBFOMTWFBU-UHFFFAOYSA-N 745521 US12319655, Example 7 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745521 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745521&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930157 518818258 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1531987 CCOc1cc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)ccc2C)cc(-c2ccnc(NC(C)=O)c2)n1 InChI=1S/C28H24F3N5O3/c1-4-39-26-14-20(11-23(36-26)18-7-10-33-25(13-18)34-17(3)37)22-15-21(6-5-16(22)2)35-27(38)19-8-9-32-24(12-19)28(29,30)31/h5-15H,4H2,1-3H3,(H,35,38)(H,33,34,37) RMJCXBZQEXXNNQ-UHFFFAOYSA-N 745522 US12319655, Example 8 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745522 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745522&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930477 518818259 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1531991 CCOc1cc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)c(F)cc2C)cc(-c2ccnc(NC(C)=O)c2)n1 InChI=1S/C28H23F4N5O3/c1-4-40-26-13-19(10-22(36-26)17-5-8-34-25(12-17)35-16(3)38)20-14-23(21(29)9-15(20)2)37-27(39)18-6-7-33-24(11-18)28(30,31)32/h5-14H,4H2,1-3H3,(H,37,39)(H,34,35,38) KWSZOCRKBICSEH-UHFFFAOYSA-N 745523 US12319655, Example 9 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745523 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745523&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929284 518818260 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1531995 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)c(F)cc3C)cc(OC(C)C)n2)ccn1 InChI=1S/C29H25F4N5O3/c1-15(2)41-27-13-20(10-23(37-27)18-5-8-35-26(12-18)36-17(4)39)21-14-24(22(30)9-16(21)3)38-28(40)19-6-7-34-25(11-19)29(31,32)33/h5-15H,1-4H3,(H,38,40)(H,35,36,39) IMGXCVNJOWBYPV-UHFFFAOYSA-N 745526 US12319655, Example 10 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745526 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745526&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929636 518818263 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1531999 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)cc(=O)n2C)ccn1 InChI=1S/C27H22F3N5O3/c1-15-4-5-20(34-26(38)18-7-8-31-23(11-18)27(28,29)30)14-21(15)19-10-22(35(3)25(37)13-19)17-6-9-32-24(12-17)33-16(2)36/h4-14H,1-3H3,(H,34,38)(H,32,33,36) HRHXTZWTNSWFEB-UHFFFAOYSA-N 745529 US12319655, Example 11 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745529 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745529&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929644 518818266 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532003 CCOc1cc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)ccc2C)cc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H26F3N5O3/c1-3-41-27-15-21(12-24(37-27)19-8-11-35-26(14-19)38-28(39)18-5-6-18)23-16-22(7-4-17(23)2)36-29(40)20-9-10-34-25(13-20)30(31,32)33/h4,7-16,18H,3,5-6H2,1-2H3,(H,36,40)(H,35,38,39) VJUKLQXECYFIOO-UHFFFAOYSA-N 745531 US12319655, Example 12 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745531 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745531&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929737 518818268 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532007 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)n(C)c(=O)c1 InChI=1S/C29H24F3N5O3/c1-16-3-6-21(35-28(40)19-8-9-33-24(12-19)29(30,31)32)15-22(16)20-11-23(37(2)26(38)14-20)18-7-10-34-25(13-18)36-27(39)17-4-5-17/h3,6-15,17H,4-5H2,1-2H3,(H,35,40)(H,34,36,39) RNBIBUUDKZOVCK-UHFFFAOYSA-N 745532 US12319655, Example 13 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745532 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745532&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929801 518818269 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532011 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)cc(C3CC3)n2)ccn1 InChI=1S/C29H24F3N5O2/c1-16-3-6-22(36-28(39)20-8-9-33-26(13-20)29(30,31)32)15-23(16)21-11-24(18-4-5-18)37-25(12-21)19-7-10-34-27(14-19)35-17(2)38/h3,6-15,18H,4-5H2,1-2H3,(H,36,39)(H,34,35,38) LRGXVUJQQTXGNH-UHFFFAOYSA-N 745535 US12319655, Example 14 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745535 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745535&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929391 518818271 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532015 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)cc(N3CCOCC3)n2)ccn1 InChI=1S/C30H27F3N6O3/c1-18-3-4-23(37-29(41)21-6-7-34-26(14-21)30(31,32)33)17-24(18)22-13-25(20-5-8-35-27(15-20)36-19(2)40)38-28(16-22)39-9-11-42-12-10-39/h3-8,13-17H,9-12H2,1-2H3,(H,37,41)(H,35,36,40) NWZYLDMRCGZFNC-UHFFFAOYSA-N 745537 US12319655, Example 15 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745537 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745537&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929680 518818273 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532019 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccnc(N)c2)c1 InChI=1S/C24H18F3N5O/c1-14-2-3-18(32-23(33)17-6-8-30-21(11-17)24(25,26)27)13-19(14)15-4-7-29-20(10-15)16-5-9-31-22(28)12-16/h2-13H,1H3,(H2,28,31)(H,32,33) CMQYLYNTLUNXLB-UHFFFAOYSA-N 745538 US12319655, Example 16 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745538 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745538&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929358 518818274 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532023 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)CN(C)C)c2)c1 InChI=1S/C28H25F3N6O2/c1-17-4-5-21(35-27(39)20-8-10-33-24(13-20)28(29,30)31)15-22(17)18-6-9-32-23(12-18)19-7-11-34-25(14-19)36-26(38)16-37(2)3/h4-15H,16H2,1-3H3,(H,35,39)(H,34,36,38) FMKQLGPXDNQNPC-UHFFFAOYSA-N 745539 US12319655, Example 17 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745539 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745539&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929844 518818275 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532027 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccnc3c2CC(=O)N3)c1 InChI=1S/C26H18F3N5O2/c1-14-2-3-17(33-25(36)16-5-8-31-22(11-16)26(27,28)29)12-19(14)15-4-7-30-21(10-15)18-6-9-32-24-20(18)13-23(35)34-24/h2-12H,13H2,1H3,(H,33,36)(H,32,34,35) FYXFOHZIBNMRAR-UHFFFAOYSA-N 745540 US12319655, Example 18 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745540 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745540&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930082 518818276 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532031 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)ccn2)ccn1 InChI=1S/C29H26N6O2/c1-18-5-6-23(35-28(37)22-9-11-32-26(14-22)29(3,4)17-30)16-24(18)20-7-10-31-25(13-20)21-8-12-33-27(15-21)34-19(2)36/h5-16H,1-4H3,(H,35,37)(H,33,34,36) BKLFUWLDGPMPPO-UHFFFAOYSA-N 745541 US12319655, Example 19 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745541&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930295 518818277 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532035 Cc1cc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)ccc2C)cc(-c2ccnc3c2CC(=O)N3)n1 InChI=1S/C27H20F3N5O2/c1-14-3-4-18(34-26(37)16-5-7-31-23(11-16)27(28,29)30)12-20(14)17-9-15(2)33-22(10-17)19-6-8-32-25-21(19)13-24(36)35-25/h3-12H,13H2,1-2H3,(H,34,37)(H,32,35,36) CYXCXGCNFRTXST-UHFFFAOYSA-N 745542 US12319655, Example 20 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745542 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745542&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930663 518818278 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532039 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)cn(C)c2=O)ccn1 InChI=1S/C27H22F3N5O3/c1-15-4-5-20(34-25(37)18-7-8-31-23(11-18)27(28,29)30)13-21(15)19-10-22(26(38)35(3)14-19)17-6-9-32-24(12-17)33-16(2)36/h4-14H,1-3H3,(H,34,37)(H,32,33,36) UQIGPBDCUDBAID-UHFFFAOYSA-N 745543 N-(3-(2'-acetamido-1-methyl-2-oxo-1,2-dihydro-[3,4'-bipyridin]-5-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide::US12319655, Example 21 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745543 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745543&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929516 518818279 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532043 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1nccc(-c2ccnc3c2CC(=O)N3)n1 InChI=1S/C28H23N7O2/c1-16-4-5-18(33-27(37)17-6-9-30-23(12-17)28(2,3)15-29)13-20(16)25-32-11-8-22(34-25)19-7-10-31-26-21(19)14-24(36)35-26/h4-13H,14H2,1-3H3,(H,33,37)(H,31,35,36) OMURTLBPLXVYLX-UHFFFAOYSA-N 745544 US12319655, Example 22 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745544 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745544&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930639 518818280 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532047 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc3c2CC(=O)N3)c1 InChI=1S/C29H24N6O2/c1-17-4-5-20(34-28(37)19-7-10-32-25(13-19)29(2,3)16-30)14-22(17)18-6-9-31-24(12-18)21-8-11-33-27-23(21)15-26(36)35-27/h4-14H,15H2,1-3H3,(H,34,37)(H,33,35,36) LNNPHWHQKZPOIL-UHFFFAOYSA-N 745545 US12319655, Example 23 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745545 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745545&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929544 518818281 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532051 CC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)n2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-3-4-18(33-24(36)17-6-8-29-21(11-17)25(26,27)28)13-19(14)20-7-10-31-23(34-20)16-5-9-30-22(12-16)32-15(2)35/h3-13H,1-2H3,(H,33,36)(H,30,32,35) UNVISLYTKUWZNL-UHFFFAOYSA-N 745546 US12319655, Example 24 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745546 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745546&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930013 518818282 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532055 CNC(=O)c1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)n2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-3-4-17(33-23(35)16-6-9-31-21(12-16)25(26,27)28)13-18(14)19-7-10-32-22(34-19)15-5-8-30-20(11-15)24(36)29-2/h3-13H,1-2H3,(H,29,36)(H,33,35) DWTMMJMIVXGWBO-UHFFFAOYSA-N 745547 US12319655, Example 25 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745547 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745547&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929781 518818283 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532059 CC(=O)Nc1cc(-c2cc(-c3cc(C(=O)Nc4ccnc(C(F)(F)F)c4)ccc3C)ccn2)ccn1 InChI=1S/C26H20F3N5O2/c1-15-3-4-19(25(36)34-20-7-10-31-23(14-20)26(27,28)29)11-21(15)17-5-8-30-22(12-17)18-6-9-32-24(13-18)33-16(2)35/h3-14H,1-2H3,(H,31,34,36)(H,32,33,35) SYKUZXYNWVXHAJ-UHFFFAOYSA-N 745548 US12319655, Example 26 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745548 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745548&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170103109 518818284 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532063 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)cc(C3CC3)n2)ccn1 InChI=1S/C29H24F3N5O2/c1-16-3-6-21(36-27(38)19-8-10-35-26(14-19)29(30,31)32)15-22(16)20-12-23(17-4-5-17)37-24(13-20)18-7-9-34-25(11-18)28(39)33-2/h3,6-15,17H,4-5H2,1-2H3,(H,33,39)(H,36,38) BBFLSCICKGKJDY-UHFFFAOYSA-N 745549 US12319655, Example 27 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745549 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745549&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930683 518818285 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532067 CC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)c2)ccn1 InChI=1S/C27H21F3N4O2/c1-16-6-7-22(34-26(36)21-9-10-31-24(13-21)27(28,29)30)15-23(16)20-5-3-4-18(12-20)19-8-11-32-25(14-19)33-17(2)35/h3-15H,1-2H3,(H,34,36)(H,32,33,35) LVMOXJABDAFEPK-UHFFFAOYSA-N 745550 US12319655, Example 28 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745550 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745550&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930649 518818286 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532071 CC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)n2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-3-4-18(33-24(36)17-6-7-30-22(9-17)25(26,27)28)11-19(14)21-13-29-12-20(34-21)16-5-8-31-23(10-16)32-15(2)35/h3-13H,1-2H3,(H,33,36)(H,31,32,35) RRVQVEBNQWWJNZ-UHFFFAOYSA-N 745551 US12319655, Example 29 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745551 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745551&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930386 518818287 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532075 CC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)c2)ncn1 InChI=1S/C26H20F3N5O2/c1-15-6-7-20(34-25(36)19-8-9-30-23(11-19)26(27,28)29)12-21(15)17-4-3-5-18(10-17)22-13-24(32-14-31-22)33-16(2)35/h3-14H,1-2H3,(H,34,36)(H,31,32,33,35) PWMOHWGZKUNAKF-UHFFFAOYSA-N 745552 US12319655, Example 30 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745552 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745552&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930561 518818288 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532079 CNC(=O)c1cc(-c2cc(-c3cc(C(=O)Nc4ccnc(C(F)(F)F)c4)ccc3C)ccn2)ccn1 InChI=1S/C26H20F3N5O2/c1-15-3-4-18(24(35)34-19-7-10-33-23(14-19)26(27,28)29)11-20(15)16-5-8-31-21(12-16)17-6-9-32-22(13-17)25(36)30-2/h3-14H,1-2H3,(H,30,36)(H,33,34,35) IWQBUBKIXKEIOC-UHFFFAOYSA-N 745553 US12319655, Example 31 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745553 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745553&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929875 518818289 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532083 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4cccc(C)c4)ccc3C)ccn2)ccn1 InChI=1S/C27H24N4O2/c1-17-5-4-6-22(13-17)27(33)31-23-8-7-18(2)24(16-23)20-9-11-28-25(14-20)21-10-12-29-26(15-21)30-19(3)32/h4-16H,1-3H3,(H,31,33)(H,29,30,32) SQGDIMWKKYWJCN-UHFFFAOYSA-N 745554 US12319655, Example 32 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745554 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745554&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929583 518818290 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532087 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)cc(C(C)(C)O)n2)ccn1 InChI=1S/C29H26F3N5O3/c1-16-5-6-21(36-27(39)19-8-9-33-25(12-19)29(30,31)32)15-22(16)20-11-23(37-24(13-20)28(3,4)40)18-7-10-34-26(14-18)35-17(2)38/h5-15,40H,1-4H3,(H,36,39)(H,34,35,38) OGSFADMLHRSGDS-UHFFFAOYSA-N 745555 US12319655, Example 33 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745555 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745555&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930686 518818291 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532091 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)nn(C)c2=O)ccn1 InChI=1S/C26H21F3N6O3/c1-14-4-5-18(33-24(37)17-7-8-30-22(10-17)26(27,28)29)12-19(14)21-13-20(25(38)35(3)34-21)16-6-9-31-23(11-16)32-15(2)36/h4-13H,1-3H3,(H,33,37)(H,31,32,36) FKAKPUIQQXRWEY-UHFFFAOYSA-N 745556 US12319655, Example 34 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745556 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745556&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930338 518818292 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532095 Cc1cc(F)c(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccnc(NC=O)c2)c1 InChI=1S/C25H17F4N5O2/c1-14-8-19(26)21(34-24(36)17-4-6-31-22(10-17)25(27,28)29)12-18(14)15-2-5-30-20(9-15)16-3-7-32-23(11-16)33-13-35/h2-13H,1H3,(H,34,36)(H,32,33,35) YGCFWFWSQSOHAR-UHFFFAOYSA-N 745557 US12319655, Example 35 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745557 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745557&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929446 518818293 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532099 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)cnc3C)ccn2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-20(16-3-6-29-21(9-16)17-4-8-31-23(11-17)33-15(2)35)12-19(13-32-14)34-24(36)18-5-7-30-22(10-18)25(26,27)28/h3-13H,1-2H3,(H,34,36)(H,31,33,35) LEXXCLDWFDOPNU-UHFFFAOYSA-N 745558 US12319655, Example 36 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745558 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745558&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930456 518818294 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532103 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)cnc3C)ccn2)ccn1 InChI=1S/C26H20F3N5O2/c1-15-22(17-6-8-30-23(11-17)18-7-9-31-24(12-18)33-16(2)35)13-21(14-32-15)34-25(36)19-4-3-5-20(10-19)26(27,28)29/h3-14H,1-2H3,(H,34,36)(H,31,33,35) WGCOHDBYLFGNFA-UHFFFAOYSA-N 745559 US12319655, Example 37 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745559 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745559&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929723 518818295 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532107 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cccc(-c2ccnc(N)c2)c1 InChI=1S/C25H19F3N4O/c1-15-5-6-20(32-24(33)19-8-9-30-22(12-19)25(26,27)28)14-21(15)18-4-2-3-16(11-18)17-7-10-31-23(29)13-17/h2-14H,1H3,(H2,29,31)(H,32,33) PBJKEEPNIVJDAV-UHFFFAOYSA-N 745560 US12319655, Example 38 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745560 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745560&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930311 518818296 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532111 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)CC#N)c2)c1 InChI=1S/C27H19F3N6O2/c1-16-2-3-20(35-26(38)19-7-10-33-23(13-19)27(28,29)30)15-21(16)17-5-9-32-22(12-17)18-6-11-34-24(14-18)36-25(37)4-8-31/h2-3,5-7,9-15H,4H2,1H3,(H,35,38)(H,34,36,37) LSNRVQFXFNHFFQ-UHFFFAOYSA-N 745561 US12319655, Example 39 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745561 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745561&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930556 518818297 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532115 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C)c4)ccc3C)ccn2)ccn1 InChI=1S/C26H23N5O2/c1-16-4-5-21(31-25(32)20-8-9-28-17(2)12-20)15-22(16)18-6-10-29-23(13-18)19-7-11-30-24(14-19)26(33)27-3/h4-15H,1-3H3,(H,27,33)(H,31,32) ZTAJXXFQFBILKS-UHFFFAOYSA-N 745562 US12319655, Example 40 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745562 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745562&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930623 518818298 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532119 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)nc(N(C)C)n2)ccn1 InChI=1S/C27H24F3N7O2/c1-15-5-6-19(34-25(39)18-8-9-31-23(11-18)27(28,29)30)13-20(15)22-14-21(35-26(36-22)37(3)4)17-7-10-32-24(12-17)33-16(2)38/h5-14H,1-4H3,(H,34,39)(H,32,33,38) OFVUWEPNGORZSX-UHFFFAOYSA-N 745563 US12319655, Example 41 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745563 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745563&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930354 518818299 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532123 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)cnc3C)ccn2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-19(15-3-6-30-20(9-15)16-4-7-31-21(10-16)24(36)29-2)12-18(13-33-14)34-23(35)17-5-8-32-22(11-17)25(26,27)28/h3-13H,1-2H3,(H,29,36)(H,34,35) WSABSKXPXJLZIT-UHFFFAOYSA-N 745564 US12319655, Example 42 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745564 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745564&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930653 518818300 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532127 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cncc(-c2ccnc3c2CC(=O)N3)n1 InChI=1S/C28H23N7O2/c1-16-4-5-18(33-27(37)17-6-8-31-24(10-17)28(2,3)15-29)11-20(16)23-14-30-13-22(34-23)19-7-9-32-26-21(19)12-25(36)35-26/h4-11,13-14H,12H2,1-3H3,(H,33,37)(H,32,35,36) FWWIAQFXHFNKBS-UHFFFAOYSA-N 745565 US12319655, Example 43 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745565&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024702 518818301 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532131 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccncc2)c1 InChI=1S/C24H17F3N4O/c1-15-2-3-19(31-23(32)18-7-11-30-22(13-18)24(25,26)27)14-20(15)17-6-10-29-21(12-17)16-4-8-28-9-5-16/h2-14H,1H3,(H,31,32) WANIXWNFESXTFB-UHFFFAOYSA-N 745566 US12319655, Example 44 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745566 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745566&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930689 518818302 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532135 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2cncnc2)c1 InChI=1S/C23H16F3N5O/c1-14-2-3-18(31-22(32)16-5-7-30-21(9-16)23(24,25)26)10-19(14)15-4-6-29-20(8-15)17-11-27-13-28-12-17/h2-13H,1H3,(H,31,32) MYYMVWABLTVVBM-UHFFFAOYSA-N 745567 US12319655, Example 45 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745567 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745567&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930212 518818303 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532139 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccnc(NC=O)c2)c1 InChI=1S/C25H18F3N5O2/c1-15-2-3-19(33-24(35)18-6-8-30-22(11-18)25(26,27)28)13-20(15)16-4-7-29-21(10-16)17-5-9-31-23(12-17)32-14-34/h2-14H,1H3,(H,33,35)(H,31,32,34) SJQQDMJHXIHENF-UHFFFAOYSA-N 745568 US12319655, Example 46 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745568&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930413 518818304 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532143 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)n2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-3-4-17(33-23(35)16-6-8-32-22(10-16)25(26,27)28)11-18(14)21-13-30-12-20(34-21)15-5-7-31-19(9-15)24(36)29-2/h3-13H,1-2H3,(H,29,36)(H,33,35) BFUVCHUUEANXJO-UHFFFAOYSA-N 745569 US12319655, Example 47 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745569&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929689 518818305 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532147 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)F)c4)ccc3C)ccn2)ccn1 InChI=1S/C26H21F2N5O2/c1-15-3-4-19(33-25(34)18-7-10-31-22(13-18)24(27)28)14-20(15)16-5-8-30-21(11-16)17-6-9-32-23(12-17)26(35)29-2/h3-14,24H,1-2H3,(H,29,35)(H,33,34) MRKWFKGILLEOFO-UHFFFAOYSA-N 745570 US12319655, Example 48 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745570&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930455 518818306 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532151 Cc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)ccn2)ccn1 InChI=1S/C28H25N5O/c1-18-5-6-23(33-27(34)22-9-12-32-26(15-22)28(3,4)17-29)16-24(18)20-7-11-31-25(14-20)21-8-10-30-19(2)13-21/h5-16H,1-4H3,(H,33,34) QRGSNGWQMDBXHG-UHFFFAOYSA-N 745571 US12319655, Example 49 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745571&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929842 518818307 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532155 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)ccn2)ccn1 InChI=1S/C29H26N6O2/c1-18-5-6-22(35-27(36)21-9-12-34-26(15-21)29(2,3)17-30)16-23(18)19-7-10-32-24(13-19)20-8-11-33-25(14-20)28(37)31-4/h5-16H,1-4H3,(H,31,37)(H,35,36) XXLUERXSMSVTAF-UHFFFAOYSA-N 745572 US12319655, Example 50 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745572 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745572&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929901 518818308 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532159 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)nn(C)c2=O)ccn1 InChI=1S/C26H21F3N6O3/c1-14-4-5-17(33-23(36)16-7-9-32-22(11-16)26(27,28)29)12-18(14)20-13-19(25(38)35(3)34-20)15-6-8-31-21(10-15)24(37)30-2/h4-13H,1-3H3,(H,30,37)(H,33,36) KDMVNZDPBKAFCQ-UHFFFAOYSA-N 745573 US12319655, Example 51 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745573&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930073 518818309 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532163 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)cnc3C)ccn2)ccn1 InChI=1S/C26H20F3N5O2/c1-15-21(16-6-8-31-22(11-16)17-7-9-32-23(12-17)25(36)30-2)13-20(14-33-15)34-24(35)18-4-3-5-19(10-18)26(27,28)29/h3-14H,1-2H3,(H,30,36)(H,34,35) JODBQIJIMIRRBO-UHFFFAOYSA-N 745574 US12319655, Example 52 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745574&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930262 518818310 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532167 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(-c2ccnc(N)c2)n(C)c(=O)c1 InChI=1S/C25H20F3N5O2/c1-14-3-4-18(32-24(35)16-6-7-30-21(10-16)25(26,27)28)13-19(14)17-9-20(33(2)23(34)12-17)15-5-8-31-22(29)11-15/h3-13H,1-2H3,(H2,29,31)(H,32,35) ASPDGRDMMBPKTC-UHFFFAOYSA-N 745575 US12319655, Example 53 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745575&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930275 518818311 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532171 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C28H22F3N5O2/c1-16-2-5-21(35-27(38)20-8-10-33-24(13-20)28(29,30)31)15-22(16)18-6-9-32-23(12-18)19-7-11-34-25(14-19)36-26(37)17-3-4-17/h2,5-15,17H,3-4H2,1H3,(H,35,38)(H,34,36,37) HLGHKOZOXTUJMA-UHFFFAOYSA-N 745576 US12319655, Example 54 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745576&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929552 518818312 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532175 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccncc2)c1 InChI=1S/C27H23N5O/c1-18-4-5-22(32-26(33)21-9-13-31-25(15-21)27(2,3)17-28)16-23(18)20-8-12-30-24(14-20)19-6-10-29-11-7-19/h4-16H,1-3H3,(H,32,33) SFWNTAYVZYJMOL-UHFFFAOYSA-N 745577 US12319655, Example 55 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745577&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930454 518818313 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532179 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(N)c2)c1 InChI=1S/C27H24N6O/c1-17-4-5-21(33-26(34)20-8-10-31-24(13-20)27(2,3)16-28)15-22(17)18-6-9-30-23(12-18)19-7-11-32-25(29)14-19/h4-15H,1-3H3,(H2,29,32)(H,33,34) UUXQERGENLMSAF-UHFFFAOYSA-N 745578 US12319655, Example 56 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745578&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930431 518818314 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532183 COCC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)c2)ccn1 InChI=1S/C28H23F3N4O3/c1-17-6-7-22(34-27(37)21-9-10-32-24(13-21)28(29,30)31)15-23(17)20-5-3-4-18(12-20)19-8-11-33-25(14-19)35-26(36)16-38-2/h3-15H,16H2,1-2H3,(H,34,37)(H,33,35,36) UCCLUFHCUBKLGY-UHFFFAOYSA-N 745579 US12319655, Example 57 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745579&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930320 518818315 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532187 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cccc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C29H23F3N4O2/c1-17-5-8-23(35-28(38)22-10-11-33-25(14-22)29(30,31)32)16-24(17)21-4-2-3-19(13-21)20-9-12-34-26(15-20)36-27(37)18-6-7-18/h2-5,8-16,18H,6-7H2,1H3,(H,35,38)(H,34,36,37) FHMPSEPTJYNECT-UHFFFAOYSA-N 745580 US12319655, Example 58 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745580&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930247 518818316 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532191 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C)c4)ccc3C)ncn2)ccn1 InChI=1S/C25H22N6O2/c1-15-4-5-20(31-25(33)19-7-8-26-16(2)10-19)12-21(15)23-13-22(28-14-29-23)18-6-9-27-24(11-18)30-17(3)32/h4-14H,1-3H3,(H,31,33)(H,27,30,32) FHQTXTFPFXMNPK-UHFFFAOYSA-N 745581 US12319655, Example 59 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745581&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929243 518818317 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532195 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C)c4)ccc3C)ncn2)ccn1 InChI=1S/C25H22N6O2/c1-15-4-5-19(31-24(32)18-7-8-27-16(2)10-18)12-20(15)22-13-21(29-14-30-22)17-6-9-28-23(11-17)25(33)26-3/h4-14H,1-3H3,(H,26,33)(H,31,32) NNKKWZLUUDDJCL-UHFFFAOYSA-N 745582 US12319655, Example 60 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745582 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745582&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930672 518818318 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532199 COCC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)ccn2)ccn1 InChI=1S/C30H28N6O3/c1-19-5-6-23(35-29(38)22-9-11-33-26(14-22)30(2,3)18-31)16-24(19)20-7-10-32-25(13-20)21-8-12-34-27(15-21)36-28(37)17-39-4/h5-16H,17H2,1-4H3,(H,35,38)(H,34,36,37) JVVGWIYYZULYDV-UHFFFAOYSA-N 745583 US12319655, Example 61 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745583 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745583&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930418 518818319 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532203 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cccc(-c2ccnc(NC(=O)CC#N)c2)c1 InChI=1S/C28H20F3N5O2/c1-17-5-6-22(35-27(38)21-9-11-33-24(14-21)28(29,30)31)16-23(17)20-4-2-3-18(13-20)19-8-12-34-25(15-19)36-26(37)7-10-32/h2-6,8-9,11-16H,7H2,1H3,(H,35,38)(H,34,36,37) STLMMSNGCQWPNF-UHFFFAOYSA-N 745584 US12319655, Example 62 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745584 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745584&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929623 518818320 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532207 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)CC#N)c2)c1 InChI=1S/C30H25N7O2/c1-19-4-5-23(36-29(39)22-9-12-34-26(15-22)30(2,3)18-32)17-24(19)20-7-11-33-25(14-20)21-8-13-35-27(16-21)37-28(38)6-10-31/h4-5,7-9,11-17H,6H2,1-3H3,(H,36,39)(H,35,37,38) QMQUYABGGPQABP-UHFFFAOYSA-N 745585 US12319655, Example 63 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745585 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745585&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929619 518818321 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532211 CC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)cnc3C)c2)ccn1 InChI=1S/C26H20F3N5O2/c1-15-22(19-5-3-4-17(10-19)18-6-9-31-24(12-18)33-16(2)35)13-21(14-32-15)34-25(36)20-7-8-30-23(11-20)26(27,28)29/h3-14H,1-2H3,(H,34,36)(H,31,33,35) UKVAFXBUZFBZGS-UHFFFAOYSA-N 745586 US12319655, Example 64 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745586 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745586&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930223 518818322 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532215 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3F)cc(C)n2)ccn1 InChI=1S/C26H19F4N5O2/c1-14-9-18(10-22(33-14)16-5-8-32-24(12-16)34-15(2)36)20-13-19(3-4-21(20)27)35-25(37)17-6-7-31-23(11-17)26(28,29)30/h3-13H,1-2H3,(H,35,37)(H,32,34,36) GHQWUOHZICKCMN-UHFFFAOYSA-N 745587 US12319655, Example 65 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745587 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745587&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930164 518818323 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532219 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3F)cc(C)n2)ccn1 InChI=1S/C26H19F4N5O2/c1-14-9-17(11-21(34-14)15-5-7-32-22(10-15)25(37)31-2)19-13-18(3-4-20(19)27)35-24(36)16-6-8-33-23(12-16)26(28,29)30/h3-13H,1-2H3,(H,31,37)(H,35,36) AOIRITKPQYNPAP-UHFFFAOYSA-N 745588 US12319655, Example 66 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745588 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745588&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930725 518818324 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532223 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)cc(=O)n2C)ccn1 InChI=1S/C27H22F3N5O3/c1-15-4-5-19(34-25(37)17-7-9-33-23(12-17)27(28,29)30)14-20(15)18-11-22(35(3)24(36)13-18)16-6-8-32-21(10-16)26(38)31-2/h4-14H,1-3H3,(H,31,38)(H,34,37) LGRKHSWKISJPNF-UHFFFAOYSA-N 745589 US12319655, Example 67 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745589 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745589&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929672 518818325 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532227 CCOc1ncc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)ccc2C)cc1-c1ccnc(NC(C)=O)c1 InChI=1S/C28H24F3N5O3/c1-4-39-27-23(18-7-10-33-25(13-18)35-17(3)37)11-20(15-34-27)22-14-21(6-5-16(22)2)36-26(38)19-8-9-32-24(12-19)28(29,30)31/h5-15H,4H2,1-3H3,(H,36,38)(H,33,35,37) DKSIKQMJHQRKNK-UHFFFAOYSA-N 745590 US12319655, Example 68 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745590&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930502 518818326 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532231 CCOc1ncc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)ccc2C)cc1-c1ccnc(C(=O)NC)c1 InChI=1S/C28H24F3N5O3/c1-4-39-27-22(17-7-9-33-23(12-17)26(38)32-3)11-19(15-35-27)21-14-20(6-5-16(21)2)36-25(37)18-8-10-34-24(13-18)28(29,30)31/h5-15H,4H2,1-3H3,(H,32,38)(H,36,37) MCBJEJUNQBNXBR-UHFFFAOYSA-N 745591 US12319655, Example 69 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745591&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930205 518818327 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532235 Cc1ncc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cccc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C28H22F3N5O2/c1-16-23(14-22(15-34-16)35-27(38)21-8-9-32-24(12-21)28(29,30)31)20-4-2-3-18(11-20)19-7-10-33-25(13-19)36-26(37)17-5-6-17/h2-4,7-15,17H,5-6H2,1H3,(H,35,38)(H,33,36,37) AIOOFTIXRVRKKO-UHFFFAOYSA-N 745592 US12319655, Example 70 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745592 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745592&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930611 518818328 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532239 CCOc1ncc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)ccc2C)cc1-c1ccnc(NC(=O)C2CC2)c1 InChI=1S/C30H26F3N5O3/c1-3-41-29-24(19-8-11-35-26(14-19)38-27(39)18-5-6-18)12-21(16-36-29)23-15-22(7-4-17(23)2)37-28(40)20-9-10-34-25(13-20)30(31,32)33/h4,7-16,18H,3,5-6H2,1-2H3,(H,37,40)(H,35,38,39) CCWGPTAYLBNRPA-UHFFFAOYSA-N 745593 US12319655, Example 71 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745593 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745593&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929423 518818329 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532243 Cc1cc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)ccc2F)cc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C28H21F4N5O2/c1-15-10-19(11-23(35-15)17-6-9-34-25(13-17)37-26(38)16-2-3-16)21-14-20(4-5-22(21)29)36-27(39)18-7-8-33-24(12-18)28(30,31)32/h4-14,16H,2-3H2,1H3,(H,36,39)(H,34,37,38) ZHJPUJZDEAUEDA-UHFFFAOYSA-N 745594 US12319655, Example 72 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745594 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745594&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930438 518818330 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532247 CNC(=O)c1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)cnc3C)c2)ccn1 InChI=1S/C26H20F3N5O2/c1-15-21(18-5-3-4-16(10-18)17-6-8-31-22(11-17)25(36)30-2)13-20(14-33-15)34-24(35)19-7-9-32-23(12-19)26(27,28)29/h3-14H,1-2H3,(H,30,36)(H,34,35) GLDUXADVHUQQAQ-UHFFFAOYSA-N 745595 US12319655, Example 73 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745595 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745595&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930062 518818331 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532251 CNC(=O)c1cc(-c2cc(-c3cc(C(=O)Nc4ccnc(C(C)(C)C#N)c4)ccc3C)ccn2)ccn1 InChI=1S/C29H26N6O2/c1-18-5-6-21(27(36)35-22-9-12-34-26(16-22)29(2,3)17-30)13-23(18)19-7-10-32-24(14-19)20-8-11-33-25(15-20)28(37)31-4/h5-16H,1-4H3,(H,31,37)(H,34,35,36) GREYQOBILOPPFB-UHFFFAOYSA-N 745596 US12319655, Example 74 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745596 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745596&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930233 518818332 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532255 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)c(F)cc3C)ccn2)ccn1 InChI=1S/C29H25FN6O2/c1-17-11-23(30)25(36-28(38)21-7-9-33-26(13-21)29(3,4)16-31)15-22(17)19-5-8-32-24(12-19)20-6-10-34-27(14-20)35-18(2)37/h5-15H,1-4H3,(H,36,38)(H,34,35,37) BPEBRWDWZLIYEF-UHFFFAOYSA-N 745597 US12319655, Example 75 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745597&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929719 518818333 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532259 Cc1cc(F)c(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C31H27FN6O2/c1-18-12-24(32)26(37-30(40)22-8-10-35-27(14-22)31(2,3)17-33)16-23(18)20-6-9-34-25(13-20)21-7-11-36-28(15-21)38-29(39)19-4-5-19/h6-16,19H,4-5H2,1-3H3,(H,37,40)(H,36,38,39) PUPDRMSAYIQEFI-UHFFFAOYSA-N 745598 US12319655, Example 76 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745598 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745598&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930615 518818334 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532263 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C31H28N6O2/c1-19-7-10-24(36-30(39)23-11-12-33-27(14-23)31(2,3)17-32)15-25(19)21-5-4-6-22(13-21)26-16-28(35-18-34-26)37-29(38)20-8-9-20/h4-7,10-16,18,20H,8-9H2,1-3H3,(H,36,39)(H,34,35,37,38) DNOFGZKCAXNCIE-UHFFFAOYSA-N 745599 US12319655, Example 77 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745599 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745599&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930294 518818335 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532267 CNC(=O)c1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C28H25N7O2/c1-17-5-6-20(34-26(36)19-8-11-32-24(14-19)28(2,3)16-29)15-21(17)22-9-12-33-25(35-22)18-7-10-31-23(13-18)27(37)30-4/h5-15H,1-4H3,(H,30,37)(H,34,36) DYCXXFOIAXELMC-UHFFFAOYSA-N 745600 US12319655, Example 78 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745600 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745600&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929327 518818336 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532271 CC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)c2)ncn1 InChI=1S/C29H26N6O2/c1-18-8-9-23(35-28(37)22-10-11-31-26(13-22)29(3,4)16-30)14-24(18)20-6-5-7-21(12-20)25-15-27(33-17-32-25)34-19(2)36/h5-15,17H,1-4H3,(H,35,37)(H,32,33,34,36) AIYFNBQQJCGBLV-UHFFFAOYSA-N 745601 US12319655, Example 79 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745601 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745601&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929389 518818337 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532275 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C28H22F3N5O2/c1-16-5-8-21(35-27(38)20-9-10-32-24(12-20)28(29,30)31)13-22(16)18-3-2-4-19(11-18)23-14-25(34-15-33-23)36-26(37)17-6-7-17/h2-5,8-15,17H,6-7H2,1H3,(H,35,38)(H,33,34,36,37) YGXSMYOUHGGENZ-UHFFFAOYSA-N 745602 US12319655, Example 80 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745602 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745602&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930177 518818338 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532279 CNC(=O)c1cc(-c2cncc(-c3cc(C(=O)Nc4cnn(C(C)C)c4)ccc3C)n2)ccn1 InChI=1S/C25H25N7O2/c1-15(2)32-14-19(11-29-32)30-24(33)18-6-5-16(3)20(9-18)23-13-27-12-22(31-23)17-7-8-28-21(10-17)25(34)26-4/h5-15H,1-4H3,(H,26,34)(H,30,33) JZVLNNOBLHKOEJ-UHFFFAOYSA-N 745603 US12319655, Example 81 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745603&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930593 518818339 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532283 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(N)c2)n1 InChI=1S/C26H23N7O/c1-16-4-5-19(32-25(34)18-7-9-29-22(12-18)26(2,3)15-27)14-20(16)21-8-11-31-24(33-21)17-6-10-30-23(28)13-17/h4-14H,1-3H3,(H2,28,30)(H,32,34) IUHBSRQKYFXDNC-UHFFFAOYSA-N 745604 US12319655, Example 82 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745604&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930339 518818340 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532287 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)nc(C)n2)ccn1 InChI=1S/C26H21F3N6O2/c1-14-4-5-19(35-25(37)18-7-8-30-23(10-18)26(27,28)29)12-20(14)22-13-21(32-15(2)33-22)17-6-9-31-24(11-17)34-16(3)36/h4-13H,1-3H3,(H,35,37)(H,31,34,36) FHYVGBLKOHDRRP-UHFFFAOYSA-N 745605 US12319655, Example 83 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745605&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930665 518818341 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532291 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)ncn2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-3-4-18(34-24(36)17-6-7-29-22(9-17)25(26,27)28)11-19(14)21-12-20(31-13-32-21)16-5-8-30-23(10-16)33-15(2)35/h3-13H,1-2H3,(H,34,36)(H,30,33,35) WUGZIOKQPXMQMO-UHFFFAOYSA-N 745606 US12319655, Example 84 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745606&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930019 518818342 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532295 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)ncn2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-3-4-17(34-23(35)16-6-8-31-22(10-16)25(26,27)28)11-18(14)20-12-19(32-13-33-20)15-5-7-30-21(9-15)24(36)29-2/h3-13H,1-2H3,(H,29,36)(H,34,35) OQZHNAMXGNNJBX-UHFFFAOYSA-N 745607 US12319655, Example 85 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745607 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745607&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930503 518818343 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532299 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C28H25N7O2/c1-17-5-6-20(34-26(36)19-8-10-33-25(12-19)28(2,3)16-29)13-21(17)24-15-31-14-23(35-24)18-7-9-32-22(11-18)27(37)30-4/h5-15H,1-4H3,(H,30,37)(H,34,36) GZFMMAHNSBIUQP-UHFFFAOYSA-N 745608 US12319655, Example 86 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745608 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745608&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929762 518818344 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532303 CC(=O)Nc1cc(-c2cncc(-c3cc(C(=O)Nc4cnn(C(C)C)c4)ccc3C)n2)ccn1 InChI=1S/C25H25N7O2/c1-15(2)32-14-20(11-28-32)30-25(34)19-6-5-16(3)21(9-19)23-13-26-12-22(31-23)18-7-8-27-24(10-18)29-17(4)33/h5-15H,1-4H3,(H,30,34)(H,27,29,33) VIHWIMSAOSQRQU-UHFFFAOYSA-N 745609 US12319655, Example 87 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745609 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745609&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930669 518818345 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532307 COCC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C29H27N7O3/c1-18-5-6-21(34-28(38)20-8-10-31-24(13-20)29(2,3)17-30)15-22(18)23-9-12-33-27(35-23)19-7-11-32-25(14-19)36-26(37)16-39-4/h5-15H,16H2,1-4H3,(H,34,38)(H,32,36,37) UXEPRVCFQYGLCK-UHFFFAOYSA-N 745610 US12319655, Example 88 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745610 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745610&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929756 518818346 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532311 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)nc(C)n2)ccn1 InChI=1S/C29H27N7O2/c1-17-6-7-22(36-28(38)21-9-10-31-26(12-21)29(4,5)16-30)14-23(17)25-15-24(33-18(2)34-25)20-8-11-32-27(13-20)35-19(3)37/h6-15H,1-5H3,(H,36,38)(H,32,35,37) VKICTZLFKKTHNH-UHFFFAOYSA-N 745611 US12319655, Example 89 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745611 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745611&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929496 518818347 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532315 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cncc(-c2ccnc(N)c2)n1 InChI=1S/C23H17F3N6O/c1-13-2-3-16(31-22(33)15-5-6-29-20(8-15)23(24,25)26)10-17(13)19-12-28-11-18(32-19)14-4-7-30-21(27)9-14/h2-12H,1H3,(H2,27,30)(H,31,33) CFBWZFYWTAZRDP-UHFFFAOYSA-N 745612 US12319655, Example 90 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745612 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745612&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929919 518818348 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532319 CNC(=O)c1cc(-c2cccc(-c3cc(NC(=O)c4cccc(C)c4)cnc3C)c2)ccn1 InChI=1S/C27H24N4O2/c1-17-6-4-9-22(12-17)26(32)31-23-15-24(18(2)30-16-23)21-8-5-7-19(13-21)20-10-11-29-25(14-20)27(33)28-3/h4-16H,1-3H3,(H,28,33)(H,31,32) SUJPNLXMWRZNAH-UHFFFAOYSA-N 745613 US12319655, Example 91 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745613 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745613&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930251 518818349 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532323 CC(=O)Nc1cc(-c2ccnc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)n2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-3-4-18(33-24(36)17-6-8-29-21(11-17)25(26,27)28)13-19(14)23-31-10-7-20(34-23)16-5-9-30-22(12-16)32-15(2)35/h3-13H,1-2H3,(H,33,36)(H,30,32,35) JPAOZPJGBMGPBR-UHFFFAOYSA-N 745614 US12319655, Example 92 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745614&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024621 518818350 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532327 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1nccc(-c2ccnc3c2CC(=O)N3)n1 InChI=1S/C27H22N8O2/c1-15-19(24-31-9-6-21(34-24)18-5-8-30-25-20(18)12-23(36)35-25)11-17(13-32-15)33-26(37)16-4-7-29-22(10-16)27(2,3)14-28/h4-11,13H,12H2,1-3H3,(H,33,37)(H,30,35,36) OHOAMIDEOJWTLV-UHFFFAOYSA-N 745615 US12319655, Example 93 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745615 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745615&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024724 518818351 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532331 Cc1ncc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cccc(-c2ccnc(N)c2)c1 InChI=1S/C24H18F3N5O/c1-14-20(17-4-2-3-15(9-17)16-5-8-30-22(28)11-16)12-19(13-31-14)32-23(33)18-6-7-29-21(10-18)24(25,26)27/h2-13H,1H3,(H2,28,30)(H,32,33) NNOHLWLEODXQHG-UHFFFAOYSA-N 745616 US12319655, Example 94 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745616 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745616&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929754 518818352 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532335 Cc1ncc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cccc(-c2ccnc(NC(=O)CN(C)C)c2)c1 InChI=1S/C28H25F3N6O2/c1-17-23(14-22(15-34-17)35-27(39)21-8-9-32-24(12-21)28(29,30)31)20-6-4-5-18(11-20)19-7-10-33-25(13-19)36-26(38)16-37(2)3/h4-15H,16H2,1-3H3,(H,35,39)(H,33,36,38) QLPIHXMPSLQIKQ-UHFFFAOYSA-N 745617 US12319655, Example 95 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745617 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745617&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929747 518818353 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532339 Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cccc(-c2ccnc(NC(=O)CC#N)c2)c1 InChI=1S/C28H20F3N5O2/c1-17-24(15-23(16-34-17)35-27(38)21-6-3-7-22(13-21)28(29,30)31)20-5-2-4-18(12-20)19-9-11-33-25(14-19)36-26(37)8-10-32/h2-7,9,11-16H,8H2,1H3,(H,35,38)(H,33,36,37) LRKMQBKZIJQWNR-UHFFFAOYSA-N 745618 US12319655, Example 97 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745618 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745618&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930508 518818354 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532343 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cncc(-c2ccnc(NC(=O)CC#N)c2)n1 InChI=1S/C26H18F3N7O2/c1-15-2-3-18(34-25(38)17-6-8-32-22(10-17)26(27,28)29)12-19(15)21-14-31-13-20(35-21)16-5-9-33-23(11-16)36-24(37)4-7-30/h2-3,5-6,8-14H,4H2,1H3,(H,34,38)(H,33,36,37) GKIVCSKSAPGIMZ-UHFFFAOYSA-N 745619 US12319655, Example 98 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745619 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745619&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930049 518818355 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532347 COCC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)n2)ccn1 InChI=1S/C26H21F3N6O3/c1-15-3-4-18(33-25(37)17-6-7-31-22(9-17)26(27,28)29)11-19(15)21-13-30-12-20(34-21)16-5-8-32-23(10-16)35-24(36)14-38-2/h3-13H,14H2,1-2H3,(H,33,37)(H,32,35,36) WFWSLDSJYBOQOL-UHFFFAOYSA-N 745620 US12319655, Example 99 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745620 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745620&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929565 518818356 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532351 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cncc(-c2ccnc(NC(=O)CN(C)C)c2)n1 InChI=1S/C27H24F3N7O2/c1-16-4-5-19(34-26(39)18-7-8-32-23(10-18)27(28,29)30)12-20(16)22-14-31-13-21(35-22)17-6-9-33-24(11-17)36-25(38)15-37(2)3/h4-14H,15H2,1-3H3,(H,34,39)(H,33,36,38) CUTAQMBIJPXYBQ-UHFFFAOYSA-N 745621 US12319655, Example 100 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745621 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745621&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024603 518818357 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532355 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc3c2CC(=O)N3)n1 InChI=1S/C28H23N7O2/c1-16-4-5-18(33-27(37)17-6-9-30-23(12-17)28(2,3)15-29)13-20(16)22-8-11-32-25(34-22)19-7-10-31-26-21(19)14-24(36)35-26/h4-13H,14H2,1-3H3,(H,33,37)(H,31,35,36) HBTXBRVRTWXCGX-UHFFFAOYSA-N 745622 US12319655, Example 101 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745622 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745622&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929429 518818358 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532359 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)cn(CCO)c2=O)ccn1 InChI=1S/C28H24F3N5O4/c1-16-3-4-21(35-26(39)19-6-7-32-24(12-19)28(29,30)31)14-22(16)20-11-23(27(40)36(15-20)9-10-37)18-5-8-33-25(13-18)34-17(2)38/h3-8,11-15,37H,9-10H2,1-2H3,(H,35,39)(H,33,34,38) HXGRBNWHNGBBCP-UHFFFAOYSA-N 745623 US12319655, Example 102 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745623 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745623&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930323 518818359 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532363 CC(=O)Nc1cc(-c2ccnc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C28H25N7O2/c1-17-5-6-21(34-27(37)20-8-10-30-24(13-20)28(3,4)16-29)15-22(17)26-32-12-9-23(35-26)19-7-11-31-25(14-19)33-18(2)36/h5-15H,1-4H3,(H,34,37)(H,31,33,36) JEKJVSSSELQULA-UHFFFAOYSA-N 745624 US12319655, Example 103 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745624 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745624&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929698 518818360 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532367 Cc1cc(F)c(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC=O)c2)c1 InChI=1S/C28H23FN6O2/c1-17-10-22(29)24(35-27(37)20-6-8-32-25(12-20)28(2,3)15-30)14-21(17)18-4-7-31-23(11-18)19-5-9-33-26(13-19)34-16-36/h4-14,16H,1-3H3,(H,35,37)(H,33,34,36) AGDSFRLJPJMVFI-UHFFFAOYSA-N 745625 US12319655, Example 104 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745625 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745625&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929315 518818361 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532371 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ccnc3c2CC(=O)N3)c1 InChI=1S/C29H24N6O2/c1-17-23(19-6-4-5-18(11-19)22-8-10-32-27-24(22)14-26(36)35-27)13-21(15-33-17)34-28(37)20-7-9-31-25(12-20)29(2,3)16-30/h4-13,15H,14H2,1-3H3,(H,34,37)(H,32,35,36) PWMCOMVOEIXFDZ-UHFFFAOYSA-N 745626 US12319655, Example 105 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745626 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745626&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929769 518818362 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532375 CNC(=O)c1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)c2)ncn1 InChI=1S/C26H20F3N5O2/c1-15-6-7-19(34-24(35)18-8-9-31-23(11-18)26(27,28)29)12-20(15)16-4-3-5-17(10-16)21-13-22(25(36)30-2)33-14-32-21/h3-14H,1-2H3,(H,30,36)(H,34,35) OTSQBKOJTMIKCB-UHFFFAOYSA-N 745627 US12319655, Example 106 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745627 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745627&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929942 518818363 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532379 CC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)c(F)cc3C)n2)ccn1 InChI=1S/C25H18F4N6O2/c1-13-9-18(26)20(35-24(37)16-4-6-30-21(10-16)25(27,28)29)12-17(13)19-5-8-32-23(34-19)15-3-7-31-22(11-15)33-14(2)36/h3-12H,1-2H3,(H,35,37)(H,31,33,36) UFEFPDLKQABGHI-UHFFFAOYSA-N 745628 US12319655, Example 107 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745628 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745628&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929932 518818364 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532383 Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cc(OCCO)nc(-c2ccnc3c2CC(=O)N3)c1 InChI=1S/C32H29N5O4/c1-19-7-8-23(35-31(40)20-5-4-6-22(13-20)32(2,3)18-33)16-25(19)21-14-27(36-29(15-21)41-12-11-38)24-9-10-34-30-26(24)17-28(39)37-30/h4-10,13-16,38H,11-12,17H2,1-3H3,(H,35,40)(H,34,37,39) REWOKGNZSBLWIU-UHFFFAOYSA-N 745629 US12319655, Example 108 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745629 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745629&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024718 518818365 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532387 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ncnc3c2CC(=O)N3)c1 InChI=1S/C29H24N6O2/c1-17-7-8-21(34-28(37)20-9-10-31-24(12-20)29(2,3)15-30)13-22(17)18-5-4-6-19(11-18)26-23-14-25(36)35-27(23)33-16-32-26/h4-13,16H,14H2,1-3H3,(H,34,37)(H,32,33,35,36) JOTVUIIMPXHJFK-UHFFFAOYSA-N 745630 US12319655, Example 109 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745630 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745630&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930392 518818366 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532391 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ncnc3c2CC(=O)N3)c1 InChI=1S/C28H23N7O2/c1-16-21(17-5-4-6-18(9-17)25-22-12-24(36)35-26(22)33-15-32-25)11-20(13-31-16)34-27(37)19-7-8-30-23(10-19)28(2,3)14-29/h4-11,13,15H,12H2,1-3H3,(H,34,37)(H,32,33,35,36) YFLJXIXKGTZICE-UHFFFAOYSA-N 745631 US12319655, Example 110 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745631 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745631&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930722 518818367 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532395 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ccnc3[nH]cnc23)c1 InChI=1S/C28H23N7O/c1-17-23(19-6-4-5-18(11-19)22-8-10-31-26-25(22)33-16-34-26)13-21(14-32-17)35-27(36)20-7-9-30-24(12-20)28(2,3)15-29/h4-14,16H,1-3H3,(H,35,36)(H,31,33,34) WSTMPJAGQYPXDA-UHFFFAOYSA-N 745632 US12319655, Example 111 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745632 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745632&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929683 518818368 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532399 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H27N7O2/c1-18-4-7-22(35-29(39)21-9-10-33-26(12-21)30(2,3)17-31)14-23(18)25-16-32-15-24(36-25)20-8-11-34-27(13-20)37-28(38)19-5-6-19/h4,7-16,19H,5-6H2,1-3H3,(H,35,39)(H,34,37,38) YPJROLQLLJCZMA-UHFFFAOYSA-N 745633 US12319655, Example 112 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745633 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745633&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929525 518818369 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532403 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)cn(C)c2=O)ccn1 InChI=1S/C30H28N6O3/c1-18-6-7-23(35-28(38)21-9-10-32-26(13-21)30(3,4)17-31)15-24(18)22-12-25(29(39)36(5)16-22)20-8-11-33-27(14-20)34-19(2)37/h6-16H,1-5H3,(H,35,38)(H,33,34,37) JAKFPJVANPQASY-UHFFFAOYSA-N 745634 US12319655, Example 113 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745634 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745634&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170098099 518818370 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532407 CC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)c(F)cc3C)c2)ncn1 InChI=1S/C26H19F4N5O2/c1-14-8-20(27)22(35-25(37)18-6-7-31-23(10-18)26(28,29)30)11-19(14)16-4-3-5-17(9-16)21-12-24(33-13-32-21)34-15(2)36/h3-13H,1-2H3,(H,35,37)(H,32,33,34,36) UXHAOPKRXMBXTN-UHFFFAOYSA-N 745635 US12319655, Example 114 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745635 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745635&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929831 518818371 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532411 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)F)c4)c(F)cc3C)cc(=O)n2C)ccn1 InChI=1S/C27H22F3N5O3/c1-14-8-19(28)20(34-26(37)16-5-7-32-21(10-16)25(29)30)13-18(14)17-11-23(35(3)24(36)12-17)15-4-6-33-22(9-15)27(38)31-2/h4-13,25H,1-3H3,(H,31,38)(H,34,37) KRJAHNIUWBTPLI-UHFFFAOYSA-N 745636 US12319655, Example 115 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745636 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745636&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024644 518818372 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532415 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)c(F)cc3C)cn(C)c2=O)ccn1 InChI=1S/C30H27FN6O3/c1-17-10-24(31)25(36-28(39)20-7-8-33-26(12-20)30(3,4)16-32)14-22(17)21-11-23(29(40)37(5)15-21)19-6-9-34-27(13-19)35-18(2)38/h6-15H,1-5H3,(H,36,39)(H,34,35,38) ZXJKSXVTVNZVDT-UHFFFAOYSA-N 745637 US12319655, Example 116 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745637 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745637&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930499 518818373 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532419 Cc1ccc(NC(=O)c2ccnc(C(F)F)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C27H22F2N6O2/c1-15-2-5-19(33-27(37)18-7-8-31-21(10-18)25(28)29)12-20(15)23-14-30-13-22(34-23)17-6-9-32-24(11-17)35-26(36)16-3-4-16/h2,5-14,16,25H,3-4H2,1H3,(H,33,37)(H,32,35,36) VYARSGAHYWTSRR-UHFFFAOYSA-N 745638 US12319655, Example 117 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745638 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745638&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024682 518818374 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532423 CC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C28H25N7O2/c1-17-5-6-21(34-27(37)20-8-10-30-24(13-20)28(3,4)16-29)15-22(17)23-9-12-32-26(35-23)19-7-11-31-25(14-19)33-18(2)36/h5-15H,1-4H3,(H,34,37)(H,31,33,36) LFHFGCXEJWERMC-UHFFFAOYSA-N 745639 US12319655, Example 118 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745639 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745639&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930248 518818375 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532427 COCCNc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)n2)ccn1 InChI=1S/C26H23F3N6O2/c1-16-3-4-19(34-25(36)18-6-7-31-23(11-18)26(27,28)29)13-20(16)22-15-30-14-21(35-22)17-5-8-32-24(12-17)33-9-10-37-2/h3-8,11-15H,9-10H2,1-2H3,(H,32,33)(H,34,36) HMDPHRQIBPYSLL-UHFFFAOYSA-N 745640 US12319655, Example 119 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745640 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745640&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929319 518818376 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532431 COc1cc(C(=O)Nc2ccc(C)c(-c3cncc(-c4ccnc(NC(C)=O)c4)n3)c2)ccc1F InChI=1S/C26H22FN5O3/c1-15-4-6-19(31-26(34)18-5-7-21(27)24(10-18)35-3)12-20(15)23-14-28-13-22(32-23)17-8-9-29-25(11-17)30-16(2)33/h4-14H,1-3H3,(H,31,34)(H,29,30,33) BTPVIABKMYFWKB-UHFFFAOYSA-N 745641 US12319655, Example 120 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745641 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745641&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929763 518818377 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532435 CC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccc(Cl)c(C(F)(F)F)c4)ccc3C)n2)ccn1 InChI=1S/C26H19ClF3N5O2/c1-14-3-5-18(34-25(37)17-4-6-21(27)20(9-17)26(28,29)30)11-19(14)23-13-31-12-22(35-23)16-7-8-32-24(10-16)33-15(2)36/h3-13H,1-2H3,(H,34,37)(H,32,33,36) YLSITAFFIARKRF-UHFFFAOYSA-N 745642 US12319655, Example 121 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745642 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745642&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929714 518818378 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532439 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccnc(N)c2)n1 InChI=1S/C23H17F3N6O/c1-13-2-3-16(31-22(33)15-5-7-28-19(10-15)23(24,25)26)12-17(13)18-6-9-30-21(32-18)14-4-8-29-20(27)11-14/h2-12H,1H3,(H2,27,29)(H,31,33) UQVXYTHLMPJCTB-UHFFFAOYSA-N 745643 US12319655, Example 122 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745643 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745643&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930252 518818379 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532443 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cncc(-c2ccnc(NC=O)c2)n1 InChI=1S/C24H17F3N6O2/c1-14-2-3-17(32-23(35)16-5-6-29-21(8-16)24(25,26)27)10-18(14)20-12-28-11-19(33-20)15-4-7-30-22(9-15)31-13-34/h2-13H,1H3,(H,32,35)(H,30,31,34) XAPOHGZHFKLGKA-UHFFFAOYSA-N 745644 US12319655, Example 123 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745644 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745644&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930340 518818380 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532447 CC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4cc(C(F)(F)F)ccn4)ccc3C)n2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-3-4-18(33-24(36)20-10-17(6-8-30-20)25(26,27)28)11-19(14)22-13-29-12-21(34-22)16-5-7-31-23(9-16)32-15(2)35/h3-13H,1-2H3,(H,33,36)(H,31,32,35) QXARRKMISXFUEC-UHFFFAOYSA-N 745645 US12319655, Example 124 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745645 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745645&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930103 518818381 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532451 CC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C29H26N6O2/c1-18-8-9-23(34-28(37)21-6-5-7-22(12-21)29(3,4)17-30)14-24(18)26-16-31-15-25(35-26)20-10-11-32-27(13-20)33-19(2)36/h5-16H,1-4H3,(H,34,37)(H,32,33,36) BNOKPVLWUKGHQN-UHFFFAOYSA-N 745646 US12319655, Example 125 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745646 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745646&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929813 518818382 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532455 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4cc(C(F)(F)F)ccn4)ccc3C)ccn2)ccn1 InChI=1S/C26H20F3N5O2/c1-15-3-4-19(34-25(36)23-13-18(7-10-33-23)26(27,28)29)14-20(15)16-5-8-31-21(11-16)17-6-9-32-22(12-17)24(35)30-2/h3-14H,1-2H3,(H,30,35)(H,34,36) VCHIDXWQBIBVPP-UHFFFAOYSA-N 745647 US12319655, Example 126 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745647 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745647&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929804 518818383 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532459 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3C)ccn2)ccn1 InChI=1S/C30H27N5O2/c1-19-8-9-24(35-28(36)22-6-5-7-23(14-22)30(2,3)18-31)17-25(19)20-10-12-33-26(15-20)21-11-13-34-27(16-21)29(37)32-4/h5-17H,1-4H3,(H,32,37)(H,35,36) RIKQEIKUDHVDFP-UHFFFAOYSA-N 745648 US12319655, Example 127 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745648 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745648&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929863 518818384 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532463 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ncnc3[nH]ncc23)c1 InChI=1S/C27H22N8O/c1-16-21(17-5-4-6-18(9-17)24-22-13-33-35-25(22)32-15-31-24)11-20(12-30-16)34-26(36)19-7-8-29-23(10-19)27(2,3)14-28/h4-13,15H,1-3H3,(H,34,36)(H,31,32,33,35) CNCRQZQUMIVMDV-UHFFFAOYSA-N 745649 US12319655, Example 129 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745649 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745649&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930046 518818385 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532467 COCC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)cnc3C)n2)ccn1 InChI=1S/C26H21F3N6O3/c1-15-19(12-18(13-32-15)33-25(37)17-7-8-30-22(10-17)26(27,28)29)21-5-3-4-20(34-21)16-6-9-31-23(11-16)35-24(36)14-38-2/h3-13H,14H2,1-2H3,(H,33,37)(H,31,35,36) WLMGKRLCFSPVPY-UHFFFAOYSA-N 745650 US12319655, Example 130 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745650 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745650&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929986 518818386 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532471 Cc1ncc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1cccc(-c2ncnc3[nH]ncc23)c1 InChI=1S/C26H21N7O/c1-15-21(17-3-2-4-18(9-17)24-22-13-31-33-25(22)30-14-29-24)11-20(12-28-15)32-26(34)19-7-8-27-23(10-19)16-5-6-16/h2-4,7-14,16H,5-6H2,1H3,(H,32,34)(H,29,30,31,33) NWRXIAVQRUHYMK-UHFFFAOYSA-N 745651 US12319655, Example 131 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745651 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745651&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024580 518818387 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532475 CC(=O)Nc1nccc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)c2)c1C#N InChI=1S/C28H20F3N5O2/c1-16-6-7-21(36-27(38)20-8-10-33-25(13-20)28(29,30)31)14-23(16)19-5-3-4-18(12-19)22-9-11-34-26(24(22)15-32)35-17(2)37/h3-14H,1-2H3,(H,36,38)(H,34,35,37) NHIIBXJQBNAUFL-UHFFFAOYSA-N 745652 US12319655, Example 132 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745652 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745652&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929507 518818388 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532479 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ccnc3[nH]ccc23)c1 InChI=1S/C30H25N5O/c1-19-7-8-23(35-29(36)22-9-12-32-27(16-22)30(2,3)18-31)17-26(19)21-6-4-5-20(15-21)24-10-13-33-28-25(24)11-14-34-28/h4-17H,1-3H3,(H,33,34)(H,35,36) IUBZCALSMHAMBL-UHFFFAOYSA-N 745653 US12319655, Example 133 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745653 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745653&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024627 518818389 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532483 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ccnc3[nH]ncc23)c1 InChI=1S/C29H24N6O/c1-18-7-8-22(34-28(36)21-9-11-31-26(14-21)29(2,3)17-30)15-24(18)20-6-4-5-19(13-20)23-10-12-32-27-25(23)16-33-35-27/h4-16H,1-3H3,(H,34,36)(H,32,33,35) WROBOOMKDPXNRK-UHFFFAOYSA-N 745654 US12319655, Example 134 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745654 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745654&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930532 518818390 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532487 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4cc(C(F)(F)F)ccn4)ccc3C)n2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-3-4-17(33-24(36)20-10-16(6-8-32-20)25(26,27)28)11-18(14)22-13-30-12-21(34-22)15-5-7-31-19(9-15)23(35)29-2/h3-13H,1-2H3,(H,29,35)(H,33,36) JUOBQFKYMFVYHI-UHFFFAOYSA-N 745655 US12319655, Example 135 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745655 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745655&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929713 518818391 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532491 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C29H26N6O2/c1-18-8-9-22(34-27(36)20-6-5-7-21(12-20)29(2,3)17-30)14-23(18)26-16-32-15-25(35-26)19-10-11-33-24(13-19)28(37)31-4/h5-16H,1-4H3,(H,31,37)(H,34,36) QIRNNRVPOCSVGQ-UHFFFAOYSA-N 745656 US12319655, Example 136 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745656 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745656&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929268 518818392 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532495 COCC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)n2)ccn1 InChI=1S/C26H21F3N6O3/c1-15-3-4-18(33-25(37)17-6-8-30-21(11-17)26(27,28)29)13-19(15)20-7-10-32-24(34-20)16-5-9-31-22(12-16)35-23(36)14-38-2/h3-13H,14H2,1-2H3,(H,33,37)(H,31,35,36) RYQNWKDPQTYLPC-UHFFFAOYSA-N 745657 US12319655, Example 137 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745657 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745657&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929977 518818393 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532499 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C5(C#N)CC5)c4)ccc3C)n2)ccn1 InChI=1S/C28H23N7O2/c1-17-3-4-20(34-26(36)19-6-10-33-25(12-19)28(16-29)7-8-28)13-21(17)24-15-31-14-23(35-24)18-5-9-32-22(11-18)27(37)30-2/h3-6,9-15H,7-8H2,1-2H3,(H,30,37)(H,34,36) CKIYUEWZFFJHEH-UHFFFAOYSA-N 745658 US12319655, Example 138 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745658 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745658&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930428 518818394 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532503 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C5CC5)c4)ccc3C)n2)ccn1 InChI=1S/C27H24N6O2/c1-16-3-6-20(32-26(34)19-8-10-30-22(12-19)17-4-5-17)13-21(16)25-15-29-14-24(33-25)18-7-9-31-23(11-18)27(35)28-2/h3,6-15,17H,4-5H2,1-2H3,(H,28,35)(H,32,34) CVXRSVCXIHTZJH-UHFFFAOYSA-N 745659 US12319655, Example 139 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745659 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745659&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930237 518818395 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532507 CC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C28H25N7O2/c1-17-5-6-21(34-27(37)20-8-9-31-25(11-20)28(3,4)16-29)13-22(17)24-15-30-14-23(35-24)19-7-10-32-26(12-19)33-18(2)36/h5-15H,1-4H3,(H,34,37)(H,32,33,36) IAIDSYIHUUDLQG-UHFFFAOYSA-N 745660 US12319655, Example 140 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745660 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745660&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930423 518818396 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532511 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cncc(-c2ccnc(N)c2)n1 InChI=1S/C26H23N7O/c1-16-4-5-19(32-25(34)18-7-8-30-23(10-18)26(2,3)15-27)12-20(16)22-14-29-13-21(33-22)17-6-9-31-24(28)11-17/h4-14H,1-3H3,(H2,28,31)(H,32,34) NMKCDRVTVOFBCQ-UHFFFAOYSA-N 745661 US12319655, Example 141 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745661 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745661&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929258 518818397 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532515 COCC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C29H27N7O3/c1-18-5-6-21(34-28(38)20-8-9-32-25(11-20)29(2,3)17-30)13-22(18)24-15-31-14-23(35-24)19-7-10-33-26(12-19)36-27(37)16-39-4/h5-15H,16H2,1-4H3,(H,34,38)(H,33,36,37) MSUXYUVBDVKNBN-UHFFFAOYSA-N 745662 US12319655, Example 142 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745662 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745662&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930009 518818398 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532519 COCCNc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C29H29N7O2/c1-19-5-6-22(35-28(37)21-8-9-32-26(13-21)29(2,3)18-30)15-23(19)25-17-31-16-24(36-25)20-7-10-33-27(14-20)34-11-12-38-4/h5-10,13-17H,11-12H2,1-4H3,(H,33,34)(H,35,37) NOPNYWBPLHEBRC-UHFFFAOYSA-N 745663 US12319655, Example 143 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745663 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745663&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930263 518818399 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532523 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)CC#N)c2)n1 InChI=1S/C26H18F3N7O2/c1-15-2-3-18(34-25(38)17-6-9-31-21(12-17)26(27,28)29)14-19(15)20-7-11-33-24(35-20)16-5-10-32-22(13-16)36-23(37)4-8-30/h2-3,5-7,9-14H,4H2,1H3,(H,34,38)(H,32,36,37) IPQGMDOWNGUQGX-UHFFFAOYSA-N 745664 US12319655, Example 144 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745664 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745664&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930616 518818400 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532527 CC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C5CC5)c4)ccc3C)n2)ccn1 InChI=1S/C27H24N6O2/c1-16-3-6-21(32-27(35)20-8-9-29-23(11-20)18-4-5-18)13-22(16)25-15-28-14-24(33-25)19-7-10-30-26(12-19)31-17(2)34/h3,6-15,18H,4-5H2,1-2H3,(H,32,35)(H,30,31,34) HLBMZLSBGFMXIS-UHFFFAOYSA-N 745665 US12319655, Example 145 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745665 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745665&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930555 518818401 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532531 CC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C5(C#N)CC5)c4)ccc3C)n2)ccn1 InChI=1S/C28H23N7O2/c1-17-3-4-21(34-27(37)20-6-9-31-25(11-20)28(16-29)7-8-28)13-22(17)24-15-30-14-23(35-24)19-5-10-32-26(12-19)33-18(2)36/h3-6,9-15H,7-8H2,1-2H3,(H,34,37)(H,32,33,36) XUROQTGKSMIAAS-UHFFFAOYSA-N 745666 US12319655, Example 146 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745666 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745666&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930231 518818402 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532535 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4cc(C(F)(F)F)cc(CN(C)C)n4)ccc3C)n2)ccn1 InChI=1S/C28H26F3N7O2/c1-16-5-6-19(36-27(40)23-11-18(28(29,30)31)10-20(35-23)15-38(3)4)12-21(16)25-14-33-13-24(37-25)17-7-8-34-22(9-17)26(39)32-2/h5-14H,15H2,1-4H3,(H,32,39)(H,36,40) GBKNKACQICKHDW-UHFFFAOYSA-N 745667 US12319655, Example 147 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745667 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745667&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929944 518818403 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532539 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cncc(-c2ccnc(C(=O)NC3CC3)c2)n1 InChI=1S/C30H27N7O2/c1-18-4-5-22(36-28(38)20-9-11-34-27(13-20)30(2,3)17-31)14-23(18)26-16-32-15-25(37-26)19-8-10-33-24(12-19)29(39)35-21-6-7-21/h4-5,8-16,21H,6-7H2,1-3H3,(H,35,39)(H,36,38) LMWPRLWEYHXQTR-UHFFFAOYSA-N 745668 US12319655, Example 148 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745668 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745668&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929735 518818404 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532543 Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cncc(-c2ccnc(C(=O)NC3CC3)c2)n1 InChI=1S/C31H28N6O2/c1-19-7-8-24(36-29(38)21-5-4-6-22(13-21)31(2,3)18-32)15-25(19)28-17-33-16-27(37-28)20-11-12-34-26(14-20)30(39)35-23-9-10-23/h4-8,11-17,23H,9-10H2,1-3H3,(H,35,39)(H,36,38) IMMCLSFRCYKTPL-UHFFFAOYSA-N 745669 US12319655, Example 149 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745669 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745669&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930218 518818405 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532547 CC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C29H26N6O2/c1-18-8-9-23(34-28(37)21-6-5-7-22(14-21)29(3,4)17-30)16-24(18)25-11-13-32-27(35-25)20-10-12-31-26(15-20)33-19(2)36/h5-16H,1-4H3,(H,34,37)(H,31,33,36) FUMHYHLCMJBSBW-UHFFFAOYSA-N 745670 US12319655, Example 150 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745670 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745670&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929291 518818406 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532551 CC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C5(C#N)CC5)c4)ccc3C)n2)ccn1 InChI=1S/C28H23N7O2/c1-17-3-4-21(34-27(37)20-6-10-30-24(13-20)28(16-29)8-9-28)15-22(17)23-7-12-32-26(35-23)19-5-11-31-25(14-19)33-18(2)36/h3-7,10-15H,8-9H2,1-2H3,(H,34,37)(H,31,33,36) SYHZYMBIWHXYAN-UHFFFAOYSA-N 745671 US12319655, Example 151 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745671 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745671&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930014 518818407 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532555 CC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C5CC5)c4)ccc3C)n2)ccn1 InChI=1S/C27H24N6O2/c1-16-3-6-21(32-27(35)20-8-10-28-24(13-20)18-4-5-18)15-22(16)23-9-12-30-26(33-23)19-7-11-29-25(14-19)31-17(2)34/h3,6-15,18H,4-5H2,1-2H3,(H,32,35)(H,29,31,34) QOYWPMWYXHLGGO-UHFFFAOYSA-N 745672 US12319655, Example 152 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745672 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745672&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930608 518818408 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532559 CC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4cc(C(F)(F)F)ccn4)ccc3C)n2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-3-4-18(33-24(36)21-12-17(6-9-29-21)25(26,27)28)13-19(14)20-7-10-31-23(34-20)16-5-8-30-22(11-16)32-15(2)35/h3-13H,1-2H3,(H,33,36)(H,30,32,35) SEOWQFSSPVZOPL-UHFFFAOYSA-N 745673 US12319655, Example 153 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745673 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745673&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929269 518818409 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532563 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cncc(-c2ccnc(NC(=O)CC#N)c2)n1 InChI=1S/C29H24N8O2/c1-18-4-5-21(35-28(39)20-8-10-33-25(12-20)29(2,3)17-31)14-22(18)24-16-32-15-23(36-24)19-7-11-34-26(13-19)37-27(38)6-9-30/h4-5,7-8,10-16H,6H2,1-3H3,(H,35,39)(H,34,37,38) DRARFQPPVUBQSR-UHFFFAOYSA-N 745674 US12319655, Example 154 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745674 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745674&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930471 518818410 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532567 CC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)c(F)cc3C)cc(=O)n2C)ccn1 InChI=1S/C27H21F4N5O3/c1-14-8-20(28)21(35-26(39)17-5-6-32-23(10-17)27(29,30)31)13-19(14)18-9-22(36(3)25(38)12-18)16-4-7-33-24(11-16)34-15(2)37/h4-13H,1-3H3,(H,35,39)(H,33,34,37) YNBKMWGQBXXLKW-UHFFFAOYSA-N 745675 US12319655, Example 155 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745675 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745675&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930597 518818411 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532571 COCCNc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)c2)ncn1 InChI=1S/C27H24F3N5O2/c1-17-6-7-21(35-26(36)20-8-9-31-24(13-20)27(28,29)30)14-22(17)18-4-3-5-19(12-18)23-15-25(34-16-33-23)32-10-11-37-2/h3-9,12-16H,10-11H2,1-2H3,(H,35,36)(H,32,33,34) XXRFGVYIMZZMHE-UHFFFAOYSA-N 745676 US12319655, Example 156 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745676 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745676&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024692 518818412 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532575 CC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)cnc3C)n2)ccn1 InChI=1S/C24H18F3N7O2/c1-13-18(19-5-8-30-22(34-19)15-3-7-29-21(10-15)32-14(2)35)11-17(12-31-13)33-23(36)16-4-6-28-20(9-16)24(25,26)27/h3-12H,1-2H3,(H,33,36)(H,29,32,35) TVUNEYFIKAZWGP-UHFFFAOYSA-N 745677 US12319655, Example 157 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745677 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745677&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929948 518818413 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532579 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)ccn2)ccn1 InChI=1S/C28H25N7O2/c1-17-22(18-5-8-31-23(11-18)19-6-9-32-24(12-19)27(37)30-4)14-21(15-34-17)35-26(36)20-7-10-33-25(13-20)28(2,3)16-29/h5-15H,1-4H3,(H,30,37)(H,35,36) YGLIEVLSWYWKIG-UHFFFAOYSA-N 745678 US12319655, Example 158 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745678 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745678&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929869 518818414 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532583 COCCNc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)c2)ncn1 InChI=1S/C29H29N7O2/c1-19-24(20-6-5-7-21(12-20)25-15-27(35-18-34-25)32-10-11-38-4)14-23(16-33-19)36-28(37)22-8-9-31-26(13-22)29(2,3)17-30/h5-9,12-16,18H,10-11H2,1-4H3,(H,36,37)(H,32,34,35) NIJJALKJGPTXNC-UHFFFAOYSA-N 745679 US12319655, Example 159 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745679 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745679&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929593 518818415 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532587 CNc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)c2)ncn1 InChI=1S/C28H26N6O/c1-18-8-9-22(34-27(35)21-10-11-31-25(13-21)28(2,3)16-29)14-23(18)19-6-5-7-20(12-19)24-15-26(30-4)33-17-32-24/h5-15,17H,1-4H3,(H,34,35)(H,30,32,33) LAMUWTUCAQNRKF-UHFFFAOYSA-N 745680 US12319655, Example 160 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745680 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745680&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929688 518818416 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532591 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cncc(-c2ccnc(NC=O)c2)n1 InChI=1S/C27H23N7O2/c1-17-4-5-20(33-26(36)19-7-8-30-24(10-19)27(2,3)15-28)12-21(17)23-14-29-13-22(34-23)18-6-9-31-25(11-18)32-16-35/h4-14,16H,1-3H3,(H,33,36)(H,31,32,35) TYUBVJRNICJJLS-UHFFFAOYSA-N 745681 US12319655, Example 161 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745681 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745681&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930619 518818417 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532595 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(C(=O)NC3CC3)c2)c1 InChI=1S/C31H28N6O2/c1-19-4-5-24(37-29(38)22-10-13-35-28(16-22)31(2,3)18-32)17-25(19)20-8-11-33-26(14-20)21-9-12-34-27(15-21)30(39)36-23-6-7-23/h4-5,8-17,23H,6-7H2,1-3H3,(H,36,39)(H,37,38) YSAXYPUERSKTEM-UHFFFAOYSA-N 745682 US12319655, Example 162 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745682 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745682&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930560 518818418 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532599 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)cc(C3CC3)n2)ccn1 InChI=1S/C32H30N6O2/c1-19-5-8-24(37-30(39)22-10-12-36-29(16-22)32(2,3)18-33)17-25(19)23-14-26(20-6-7-20)38-27(15-23)21-9-11-35-28(13-21)31(40)34-4/h5,8-17,20H,6-7H2,1-4H3,(H,34,40)(H,37,39) HFORUXTUIWTTLF-UHFFFAOYSA-N 745683 US12319655, Example 163 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745683 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745683&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930389 518818419 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532603 Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C31H28N6O2/c1-19-7-10-24(35-30(39)22-5-4-6-23(13-22)31(2,3)18-32)15-25(19)27-17-33-16-26(36-27)21-11-12-34-28(14-21)37-29(38)20-8-9-20/h4-7,10-17,20H,8-9H2,1-3H3,(H,35,39)(H,34,37,38) SMKQEOGQVPCSMK-UHFFFAOYSA-N 745684 US12319655, Example 164 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745684 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745684&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930232 518818420 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532607 CC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)C)c4)ccc3C)n2)ccn1 InChI=1S/C28H28N6O2/c1-17-6-7-21(33-27(36)20-9-10-30-25(12-20)28(3,4)5)14-22(17)24-16-29-15-23(34-24)19-8-11-31-26(13-19)32-18(2)35/h6-16H,1-5H3,(H,33,36)(H,31,32,35) DIKGXBAVGJDZGJ-UHFFFAOYSA-N 745685 US12319655, Example 165 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745685 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745685&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929350 518818421 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532611 CNC(=O)c1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)c(F)cc3C)n2)ccn1 InChI=1S/C28H24FN7O2/c1-16-11-20(29)22(36-26(37)18-6-9-33-24(13-18)28(2,3)15-30)14-19(16)21-7-10-34-25(35-21)17-5-8-32-23(12-17)27(38)31-4/h5-14H,1-4H3,(H,31,38)(H,36,37) RVSIFSLRWJEYID-UHFFFAOYSA-N 745686 US12319655, Example 166 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745686 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745686&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930056 518818422 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532615 Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccn2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C27H21F3N6O2/c1-15-2-5-19(34-26(38)21-11-18(7-9-32-21)27(28,29)30)12-20(15)23-14-31-13-22(35-23)17-6-8-33-24(10-17)36-25(37)16-3-4-16/h2,5-14,16H,3-4H2,1H3,(H,34,38)(H,33,36,37) WPIXJCXWRUKXFG-UHFFFAOYSA-N 745687 US12319655, Example 167 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745687 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745687&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929448 518818423 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532619 CC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4cnnc(C5CC5)c4)ccc3C)n2)ccn1 InChI=1S/C26H23N7O2/c1-15-3-6-20(31-26(35)19-11-23(17-4-5-17)33-29-14-19)13-21(15)22-8-10-28-25(32-22)18-7-9-27-24(12-18)30-16(2)34/h3,6-14,17H,4-5H2,1-2H3,(H,31,35)(H,27,30,34) BCSOCHDHVUBENW-UHFFFAOYSA-N 745688 US12319655, Example 168 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745688 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745688&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929870 518818424 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532623 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H27N7O2/c1-18-4-7-22(35-29(39)21-9-11-32-25(14-21)30(2,3)17-31)16-23(18)27-34-13-10-24(36-27)20-8-12-33-26(15-20)37-28(38)19-5-6-19/h4,7-16,19H,5-6H2,1-3H3,(H,35,39)(H,33,37,38) SZDJSCYTZSPRAK-UHFFFAOYSA-N 745689 US12319655, Example 169 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745689 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745689&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929703 518818425 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532627 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)c(F)cc3C)n2)ccn1 InChI=1S/C28H24FN7O2/c1-16-9-20(29)21(36-26(37)18-6-8-34-25(11-18)28(2,3)15-30)12-19(16)24-14-32-13-23(35-24)17-5-7-33-22(10-17)27(38)31-4/h5-14H,1-4H3,(H,31,38)(H,36,37) HMJWHSMHNMSHJQ-UHFFFAOYSA-N 745690 US12319655, Example 170 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745690 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745690&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929470 518818426 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532631 CNC(=O)c1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)c2)ncn1 InChI=1S/C29H26N6O2/c1-18-8-9-22(35-27(36)21-10-11-32-26(13-21)29(2,3)16-30)14-23(18)19-6-5-7-20(12-19)24-15-25(28(37)31-4)34-17-33-24/h5-15,17H,1-4H3,(H,31,37)(H,35,36) RDCVBVNAVIJDAB-UHFFFAOYSA-N 745691 US12319655, Example 171 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745691 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745691&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929562 518818427 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532635 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H27N7O2/c1-18-23(15-22(16-34-18)35-29(39)21-10-11-32-26(13-21)30(2,3)17-31)25-6-4-5-24(36-25)20-9-12-33-27(14-20)37-28(38)19-7-8-19/h4-6,9-16,19H,7-8H2,1-3H3,(H,35,39)(H,33,37,38) ZKXZDCOPCKAJND-UHFFFAOYSA-N 745692 US12319655, Example 172 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745692 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745692&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929264 518818428 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532639 CNc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C27H25N7O/c1-17-5-6-20(33-26(35)19-8-9-31-24(11-19)27(2,3)16-28)13-21(17)23-15-30-14-22(34-23)18-7-10-32-25(12-18)29-4/h5-15H,1-4H3,(H,29,32)(H,33,35) NMNAKHMWJJAKKK-UHFFFAOYSA-N 745693 US12319655, Example 173 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745693 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745693&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929873 518818429 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532643 Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C32H29N5O2/c1-20-10-13-26(36-31(39)24-8-5-9-25(15-24)32(2,3)18-33)16-27(20)22-6-4-7-23(14-22)28-17-29(35-19-34-28)37-30(38)21-11-12-21/h4-10,13-17,19,21H,11-12H2,1-3H3,(H,36,39)(H,34,35,37,38) KABJSBXMSBSFQN-UHFFFAOYSA-N 745694 US12319655, Example 174 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745694 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745694&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930509 518818430 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532647 CNC(=O)c1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C5(C#N)CC5)c4)ccc3C)n2)ccn1 InChI=1S/C28H23N7O2/c1-17-3-4-20(34-26(36)19-6-11-32-24(14-19)28(16-29)8-9-28)15-21(17)22-7-12-33-25(35-22)18-5-10-31-23(13-18)27(37)30-2/h3-7,10-15H,8-9H2,1-2H3,(H,30,37)(H,34,36) UXQQFAKWKZVFLX-UHFFFAOYSA-N 745695 US12319655, Example 175 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745695 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745695&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930260 518818431 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532651 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)c(F)cc3C)ccn2)ccn1 InChI=1S/C29H25FN6O2/c1-17-11-22(30)24(36-27(37)20-7-10-35-26(14-20)29(2,3)16-31)15-21(17)18-5-8-33-23(12-18)19-6-9-34-25(13-19)28(38)32-4/h5-15H,1-4H3,(H,32,38)(H,36,37) CQTWMFFDUDPCHP-UHFFFAOYSA-N 745696 US12319655, Example 176 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745696 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745696&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930682 518818432 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532655 CNC(=O)c1cc(-c2ccnc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C28H25N7O2/c1-17-5-6-20(34-26(36)19-8-11-32-24(14-19)28(2,3)16-29)15-21(17)25-33-12-9-22(35-25)18-7-10-31-23(13-18)27(37)30-4/h5-15H,1-4H3,(H,30,37)(H,34,36) IEQQBNASGQSSNO-UHFFFAOYSA-N 745697 US12319655, Example 177 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745697 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745697&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930108 518818433 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532659 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C5(C#N)CC5)c4)ccc3C)ncn2)ccn1 InChI=1S/C28H23N7O2/c1-17-3-4-20(35-26(36)19-6-10-32-25(12-19)28(15-29)7-8-28)13-21(17)23-14-22(33-16-34-23)18-5-9-31-24(11-18)27(37)30-2/h3-6,9-14,16H,7-8H2,1-2H3,(H,30,37)(H,35,36) DDAJPLKKTBRQGO-UHFFFAOYSA-N 745698 US12319655, Example 178 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745698 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745698&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929427 518818434 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532663 Cc1cc(F)c(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H26FN7O2/c1-17-12-22(31)24(37-29(40)20-7-9-33-25(13-20)30(2,3)16-32)15-21(17)23-8-11-35-27(36-23)19-6-10-34-26(14-19)38-28(39)18-4-5-18/h6-15,18H,4-5H2,1-3H3,(H,37,40)(H,34,38,39) JBHOWWWOJYWICH-UHFFFAOYSA-N 745699 US12319655, Example 179 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745699 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745699&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929993 518818435 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532667 Cc1ccc(NC(=O)c2ccnc(C3(C#N)CC3)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H25N7O2/c1-18-2-5-22(35-29(39)21-7-11-32-25(14-21)30(17-31)9-10-30)16-23(18)24-8-13-34-27(36-24)20-6-12-33-26(15-20)37-28(38)19-3-4-19/h2,5-8,11-16,19H,3-4,9-10H2,1H3,(H,35,39)(H,33,37,38) DQLBBCFUQXZPSF-UHFFFAOYSA-N 745700 US12319655, Example 180 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745700 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745700&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930496 518818436 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532671 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C30H27N7O2/c1-18-24(13-23(15-33-18)36-29(39)22-9-10-32-26(12-22)30(2,3)16-31)20-5-4-6-21(11-20)25-14-27(35-17-34-25)37-28(38)19-7-8-19/h4-6,9-15,17,19H,7-8H2,1-3H3,(H,36,39)(H,34,35,37,38) ATPNMGVZODSGBU-UHFFFAOYSA-N 745701 US12319655, Example 181 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745701 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745701&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929911 518818437 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532675 CCC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)n2)ccn1 InChI=1S/C29H27N7O2/c1-5-27(37)36-26-14-19(9-12-32-26)23-7-6-8-24(35-23)22-15-21(16-33-18(22)2)34-28(38)20-10-11-31-25(13-20)29(3,4)17-30/h6-16H,5H2,1-4H3,(H,34,38)(H,32,36,37) AWLIYEFVVKSROO-UHFFFAOYSA-N 745702 US12319655, Example 182 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745702 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745702&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930625 518818438 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532679 Cc1ccc(NC(=O)c2ccnc(C3(C#N)CC3)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H25N7O2/c1-18-2-5-22(35-29(39)21-7-10-33-26(12-21)30(17-31)8-9-30)14-23(18)25-16-32-15-24(36-25)20-6-11-34-27(13-20)37-28(38)19-3-4-19/h2,5-7,10-16,19H,3-4,8-9H2,1H3,(H,35,39)(H,34,37,38) ADLQKALHUAQJBK-UHFFFAOYSA-N 745703 US12319655, Example 183 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745703 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745703&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929563 518818439 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532683 Cc1ccc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C29H26N6O2/c1-17-2-7-22(33-29(37)21-9-10-31-24(12-21)18-3-4-18)14-23(17)26-16-30-15-25(34-26)20-8-11-32-27(13-20)35-28(36)19-5-6-19/h2,7-16,18-19H,3-6H2,1H3,(H,33,37)(H,32,35,36) CDMFHXZAAJBZFM-UHFFFAOYSA-N 745704 US12319655, Example 184 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745704 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745704&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929981 518818440 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532687 Cc1ccc(NC(=O)c2cc(CN(C)C)cc(C(F)(F)F)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C31H29F3N6O2/c1-18-4-7-24(37-30(42)22-10-19(17-40(2)3)11-23(12-22)31(32,33)34)14-25(18)27-16-35-15-26(38-27)21-8-9-36-28(13-21)39-29(41)20-5-6-20/h4,7-16,20H,5-6,17H2,1-3H3,(H,37,42)(H,36,39,41) YUGODVAYTVQKFD-UHFFFAOYSA-N 745705 US12319655, Example 185 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745705 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745705&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929346 518818441 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532691 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C29H27FN6O2/c1-17-4-7-21(34-28(38)20-9-11-31-24(14-20)29(2,3)30)16-22(17)23-10-13-33-26(35-23)19-8-12-32-25(15-19)36-27(37)18-5-6-18/h4,7-16,18H,5-6H2,1-3H3,(H,34,38)(H,32,36,37) XRCPHTHMKSZLRC-UHFFFAOYSA-N 745706 US12319655, Example 186 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745706 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745706&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930367 518818442 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532695 Cc1ccc(NC(=O)c2ccnc(C3(C#N)CC3)c2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H25N7O2/c1-18-2-5-22(35-29(39)21-7-11-32-25(14-21)30(17-31)9-10-30)16-23(18)27-34-13-8-24(36-27)20-6-12-33-26(15-20)37-28(38)19-3-4-19/h2,5-8,11-16,19H,3-4,9-10H2,1H3,(H,35,39)(H,33,37,38) KVMZDLPHPKEKSV-UHFFFAOYSA-N 745707 US12319655, Example 187 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745707 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745707&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930369 518818443 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532699 Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccn2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C27H21F3N6O2/c1-15-2-5-19(34-26(38)22-13-18(7-10-31-22)27(28,29)30)14-20(15)21-8-11-33-24(35-21)17-6-9-32-23(12-17)36-25(37)16-3-4-16/h2,5-14,16H,3-4H2,1H3,(H,34,38)(H,32,36,37) NGNWCUIVVQCXHZ-UHFFFAOYSA-N 745708 US12319655, Example 188 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745708 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745708&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929682 518818444 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532703 Cc1ccc(NC(=O)c2ccnc(C(F)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C27H22F2N6O2/c1-15-2-5-19(33-27(37)18-7-9-30-22(12-18)24(28)29)14-20(15)21-8-11-32-25(34-21)17-6-10-31-23(13-17)35-26(36)16-3-4-16/h2,5-14,16,24H,3-4H2,1H3,(H,33,37)(H,31,35,36) SJSWUBRTWNMMNE-UHFFFAOYSA-N 745709 US12319655, Example 189 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745709 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745709&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929854 518818445 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532707 COC(C)(C)c1cc(C(=O)Nc2ccc(C)c(-c3ccnc(-c4ccnc(NC(=O)C5CC5)c4)n3)c2)ccn1 InChI=1S/C30H30N6O3/c1-18-5-8-22(34-29(38)21-10-12-31-25(15-21)30(2,3)39-4)17-23(18)24-11-14-33-27(35-24)20-9-13-32-26(16-20)36-28(37)19-6-7-19/h5,8-17,19H,6-7H2,1-4H3,(H,34,38)(H,32,36,37) BZOWOJNDLUDRQA-UHFFFAOYSA-N 745710 US12319655, Example 190 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745710 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745710&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024725 518818446 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532711 CNC(=O)c1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)c2)cnn1 InChI=1S/C29H26N6O2/c1-18-8-9-23(34-27(36)21-10-11-32-26(14-21)29(2,3)17-30)15-24(18)20-7-5-6-19(12-20)22-13-25(28(37)31-4)35-33-16-22/h5-16H,1-4H3,(H,31,37)(H,34,36) NQSFBHMCVVZFKH-UHFFFAOYSA-N 745711 US12319655, Example 191 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745711 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745711&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024595 518818447 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532715 CNC(=O)c1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)c2)ccn1 InChI=1S/C29H26N6O2/c1-18-24(21-7-5-6-19(12-21)20-8-10-32-25(13-20)28(37)31-4)15-23(16-34-18)35-27(36)22-9-11-33-26(14-22)29(2,3)17-30/h5-16H,1-4H3,(H,31,37)(H,35,36) PWNKEDWAXGOFDP-UHFFFAOYSA-N 745712 US12319655, Example 192 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745712&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929603 518818448 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532719 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C29H26N8O2/c1-17-22(14-21(15-34-17)35-28(39)20-7-9-31-24(12-20)29(2,3)16-30)23-8-11-33-26(36-23)19-6-10-32-25(13-19)37-27(38)18-4-5-18/h6-15,18H,4-5H2,1-3H3,(H,35,39)(H,32,37,38) BSLYIICIIRTJIE-UHFFFAOYSA-N 745713 US12319655, Example 193 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745713 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745713&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930165 518818449 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532723 CNC(=O)c1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)n2)ccn1 InChI=1S/C27H24N8O2/c1-16-20(21-7-10-32-24(35-21)17-5-8-30-22(11-17)26(37)29-4)13-19(14-33-16)34-25(36)18-6-9-31-23(12-18)27(2,3)15-28/h5-14H,1-4H3,(H,29,37)(H,34,36) CMFAVTCOAOWEHG-UHFFFAOYSA-N 745714 US12319655, Example 194 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745714 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745714&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930085 518818450 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532727 CC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)n2)ccn1 InChI=1S/C27H24N8O2/c1-16-21(22-7-10-31-25(35-22)18-5-9-30-24(12-18)33-17(2)36)13-20(14-32-16)34-26(37)19-6-8-29-23(11-19)27(3,4)15-28/h5-14H,1-4H3,(H,34,37)(H,30,33,36) GLTMUXPCEOLBLW-UHFFFAOYSA-N 745715 US12319655, Example 195 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745715 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745715&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930385 518818451 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532731 CNC(=O)c1cc(-c2nc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)cc(C3CC3)n2)ccn1 InChI=1S/C31H29N7O2/c1-18-5-8-22(36-29(39)21-10-12-35-27(14-21)31(2,3)17-32)15-23(18)25-16-24(19-6-7-19)37-28(38-25)20-9-11-34-26(13-20)30(40)33-4/h5,8-16,19H,6-7H2,1-4H3,(H,33,40)(H,36,39) NYXRUDSUWFBMGT-UHFFFAOYSA-N 745716 US12319655, Example 196 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745716 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745716&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929768 518818452 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532735 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(NC(=O)C3(C)CC3)ncn2)c1 InChI=1S/C32H30N6O2/c1-20-8-9-24(37-29(39)23-10-13-34-27(15-23)31(2,3)18-33)16-25(20)21-6-5-7-22(14-21)26-17-28(36-19-35-26)38-30(40)32(4)11-12-32/h5-10,13-17,19H,11-12H2,1-4H3,(H,37,39)(H,35,36,38,40) GLZFXIJCXYGGKL-UHFFFAOYSA-N 745717 US12319655, Example 197 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745717&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929599 518818453 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532739 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C29H26N8O2/c1-17-22(14-21(15-34-17)35-28(39)20-7-9-31-24(12-20)29(2,3)16-30)26-33-11-8-23(36-26)19-6-10-32-25(13-19)37-27(38)18-4-5-18/h6-15,18H,4-5H2,1-3H3,(H,35,39)(H,32,37,38) ZGRHHDMOCDJAHD-UHFFFAOYSA-N 745718 US12319655, Example 198 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745718 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745718&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930580 518818454 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532743 CNC(=O)c1cc(-c2ccnc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)n2)ccn1 InChI=1S/C27H24N8O2/c1-16-20(24-32-10-7-21(35-24)17-5-8-30-22(11-17)26(37)29-4)13-19(14-33-16)34-25(36)18-6-9-31-23(12-18)27(2,3)15-28/h5-14H,1-4H3,(H,29,37)(H,34,36) VTOOUHAASHICBN-UHFFFAOYSA-N 745719 US12319655, Example 199 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745719 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745719&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929273 518818455 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532747 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(NC(=O)C3(F)CC3)ncn2)c1 InChI=1S/C31H27FN6O2/c1-19-7-8-23(37-28(39)22-9-12-34-26(14-22)30(2,3)17-33)15-24(19)20-5-4-6-21(13-20)25-16-27(36-18-35-25)38-29(40)31(32)10-11-31/h4-9,12-16,18H,10-11H2,1-3H3,(H,37,39)(H,35,36,38,40) ZIWAYBUWMARJTI-UHFFFAOYSA-N 745720 US12319655, Example 200 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745720 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745720&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929524 518818456 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532751 CNC(=O)c1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)c2)cnn1 InChI=1S/C28H25N7O2/c1-17-23(19-7-5-6-18(10-19)21-11-24(27(37)30-4)35-33-14-21)13-22(15-32-17)34-26(36)20-8-9-31-25(12-20)28(2,3)16-29/h5-15H,1-4H3,(H,30,37)(H,34,36) RXFMCUTTXVTWGM-UHFFFAOYSA-N 745721 US12319655, Example 201 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745721&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929922 518818457 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532755 Cc1ccc(NC(=O)c2cc(CN(C)C)cc(C(F)(F)F)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C32H30F3N5O2/c1-19-7-10-26(38-31(42)24-11-20(17-40(2)3)12-25(14-24)32(33,34)35)15-27(19)22-5-4-6-23(13-22)28-16-29(37-18-36-28)39-30(41)21-8-9-21/h4-7,10-16,18,21H,8-9,17H2,1-3H3,(H,38,42)(H,36,37,39,41) ZKCSOLYZNJNDFO-UHFFFAOYSA-N 745722 US12319655, Example 202 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745722 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745722&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929349 518818458 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532759 Cc1ccc(NC(=O)c2ccnc(C3(C#N)CC3)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C31H26N6O2/c1-19-5-8-24(36-30(39)23-9-12-33-27(14-23)31(17-32)10-11-31)15-25(19)21-3-2-4-22(13-21)26-16-28(35-18-34-26)37-29(38)20-6-7-20/h2-5,8-9,12-16,18,20H,6-7,10-11H2,1H3,(H,36,39)(H,34,35,37,38) IZYSUOATRMNLRA-UHFFFAOYSA-N 745723 US12319655, Example 203 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745723 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745723&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929848 518818459 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532763 CNC(=O)c1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)c2)ncn1 InChI=1S/C28H25N7O2/c1-17-22(18-6-5-7-19(10-18)23-13-24(27(37)30-4)34-16-33-23)12-21(14-32-17)35-26(36)20-8-9-31-25(11-20)28(2,3)15-29/h5-14,16H,1-4H3,(H,30,37)(H,35,36) VKCHXVMHWUZBLM-UHFFFAOYSA-N 745724 US12319655, Example 204 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745724 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745724&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929445 518818460 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532767 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3F)ccn2)ccn1 InChI=1S/C28H23FN6O2/c1-28(2,16-30)25-14-19(8-11-34-25)26(36)35-20-4-5-22(29)21(15-20)17-6-9-32-23(12-17)18-7-10-33-24(13-18)27(37)31-3/h4-15H,1-3H3,(H,31,37)(H,35,36) KRMWNHLHSGORLC-UHFFFAOYSA-N 745725 US12319655, Example 205 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745725 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745725&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930563 518818461 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532771 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C(C)(C)C)c2)c1 InChI=1S/C32H32N6O2/c1-20-7-8-24(37-29(39)23-11-13-35-27(16-23)32(5,6)19-33)18-25(20)21-9-12-34-26(15-21)22-10-14-36-28(17-22)38-30(40)31(2,3)4/h7-18H,1-6H3,(H,37,39)(H,36,38,40) WPRYVXHULMLQJU-UHFFFAOYSA-N 745726 US12319655, Example 206 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745726 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745726&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930406 518818462 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532775 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(N)ncn2)c1 InChI=1S/C26H23N7O/c1-16-21(17-5-4-6-18(9-17)22-12-24(28)32-15-31-22)11-20(13-30-16)33-25(34)19-7-8-29-23(10-19)26(2,3)14-27/h4-13,15H,1-3H3,(H,33,34)(H2,28,31,32) IINORLRJJWZRHU-UHFFFAOYSA-N 745727 US12319655, Example 207 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745727&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024559 518818463 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532779 COC(C)(C)C(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)c2)ncn1 InChI=1S/C31H31N7O3/c1-19-24(14-23(16-34-19)37-28(39)22-10-11-33-26(13-22)30(2,3)17-32)20-8-7-9-21(12-20)25-15-27(36-18-35-25)38-29(40)31(4,5)41-6/h7-16,18H,1-6H3,(H,37,39)(H,35,36,38,40) QZWZZJRIXZUWBZ-UHFFFAOYSA-N 745728 US12319655, Example 208 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745728 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745728&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929929 518818464 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532783 COC(C)(C)C(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)ccn2)ccn1 InChI=1S/C31H31N7O3/c1-19-24(16-23(17-36-19)37-28(39)22-9-11-34-26(14-22)30(2,3)18-32)20-7-10-33-25(13-20)21-8-12-35-27(15-21)38-29(40)31(4,5)41-6/h7-17H,1-6H3,(H,37,39)(H,35,38,40) DCFJWQQXWGCOCK-UHFFFAOYSA-N 745729 US12319655, Example 209 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745729&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930327 518818465 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532787 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(NC(=O)C(C)(C)C)ncn2)c1 InChI=1S/C32H32N6O2/c1-20-10-11-24(37-29(39)23-12-13-34-27(15-23)32(5,6)18-33)16-25(20)21-8-7-9-22(14-21)26-17-28(36-19-35-26)38-30(40)31(2,3)4/h7-17,19H,1-6H3,(H,37,39)(H,35,36,38,40) MSYJEBFRCFOKQU-UHFFFAOYSA-N 745730 US12319655, Example 210 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745730 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745730&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930481 518818466 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532791 COC(C)(C)C(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)c2)ncn1 InChI=1S/C32H32N6O3/c1-20-10-11-24(37-29(39)23-12-13-34-27(15-23)31(2,3)18-33)16-25(20)21-8-7-9-22(14-21)26-17-28(36-19-35-26)38-30(40)32(4,5)41-6/h7-17,19H,1-6H3,(H,37,39)(H,35,36,38,40) VKRZAJWWFMWJDQ-UHFFFAOYSA-N 745731 US12319655, Example 211 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745731 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745731&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930077 518818467 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532795 Cc1cc(-c2cc(NC(=O)C3CC3)ncn2)cc(-c2cc(NC(=O)c3ccnc(C(C)(C)C#N)c3)ccc2C)c1 InChI=1S/C32H30N6O2/c1-19-11-23(13-24(12-19)27-16-29(36-18-35-27)38-30(39)21-6-7-21)26-15-25(8-5-20(26)2)37-31(40)22-9-10-34-28(14-22)32(3,4)17-33/h5,8-16,18,21H,6-7H2,1-4H3,(H,37,40)(H,35,36,38,39) WZWBBQHPDBDBLW-UHFFFAOYSA-N 745732 US12319655, Example 212 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745732 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745732&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024560 518818468 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532799 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(NC(=O)C(C)(C)C)ncn2)c1 InChI=1S/C31H31N7O2/c1-19-24(14-23(16-34-19)37-28(39)22-10-11-33-26(13-22)31(5,6)17-32)20-8-7-9-21(12-20)25-15-27(36-18-35-25)38-29(40)30(2,3)4/h7-16,18H,1-6H3,(H,37,39)(H,35,36,38,40) ALMLAIUJUCVHJY-UHFFFAOYSA-N 745733 US12319655, Example 213 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745733 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745733&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930538 518818469 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532803 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)ccn2)ccn1 InChI=1S/C28H26FN5O2/c1-17-5-6-21(34-26(35)20-9-12-33-25(15-20)28(2,3)29)16-22(17)18-7-10-31-23(13-18)19-8-11-32-24(14-19)27(36)30-4/h5-16H,1-4H3,(H,30,36)(H,34,35) IOHMOFMPUPAQNC-UHFFFAOYSA-N 745734 US12319655, Example 214 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745734 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745734&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929259 518818470 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532807 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4cnnc(C5CC5)c4)ccc3C)ccn2)ccn1 InChI=1S/C27H24N6O2/c1-16-3-6-21(32-26(34)20-13-24(17-4-5-17)33-31-15-20)14-22(16)18-7-9-29-23(11-18)19-8-10-30-25(12-19)27(35)28-2/h3,6-15,17H,4-5H2,1-2H3,(H,28,35)(H,32,34) IGNHCWCHWHXJAT-UHFFFAOYSA-N 745735 US12319655, Example 215 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745735 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745735&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024730 518818471 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532811 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(-c2cc(NC(=O)C3CC3)ncn2)cc(C2CC2)c1 InChI=1S/C34H32N6O2/c1-20-4-9-27(39-33(42)23-10-11-36-30(15-23)34(2,3)18-35)16-28(20)25-12-24(21-5-6-21)13-26(14-25)29-17-31(38-19-37-29)40-32(41)22-7-8-22/h4,9-17,19,21-22H,5-8H2,1-3H3,(H,39,42)(H,37,38,40,41) BGRNZLKHVKLDCL-UHFFFAOYSA-N 745736 US12319655, Example 216 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745736 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745736&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024635 518818472 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532815 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3C)cc(C)n2)ccn1 InChI=1S/C31H29N5O2/c1-19-9-10-25(36-29(37)22-7-6-8-24(14-22)31(3,4)18-32)17-26(19)23-13-20(2)35-27(16-23)21-11-12-34-28(15-21)30(38)33-5/h6-17H,1-5H3,(H,33,38)(H,36,37) HQCODKIAJNTDBI-UHFFFAOYSA-N 745737 US12319655, Example 217 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745737 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745737&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170104010 518818473 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532819 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(-c2cc(NC(=O)C3CC3)ncn2)cc(C2CC2)c1 InChI=1S/C33H31N7O2/c1-19-27(14-26(16-36-19)39-32(42)22-8-9-35-29(13-22)33(2,3)17-34)24-10-23(20-4-5-20)11-25(12-24)28-15-30(38-18-37-28)40-31(41)21-6-7-21/h8-16,18,20-21H,4-7H2,1-3H3,(H,39,42)(H,37,38,40,41) KBYNGMQNJNLGNQ-UHFFFAOYSA-N 745738 US12319655, Example 218 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745738 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745738&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930603 518818474 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532823 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C(C)(C)C#N)c2)c1 InChI=1S/C31H28N8O2/c1-19-24(15-23(16-37-19)38-28(40)22-8-10-35-26(13-22)30(2,3)17-32)20-6-9-34-25(12-20)21-7-11-36-27(14-21)39-29(41)31(4,5)18-33/h6-16H,1-5H3,(H,38,40)(H,36,39,41) JGLMDZMIICAOSX-UHFFFAOYSA-N 745739 US12319655, Example 219 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745739 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745739&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929322 518818475 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532827 Cc1ccc(NC(=O)c2ccnc(C3(C#N)CC3)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)n1 InChI=1S/C30H25N7O2/c1-18-5-8-21(35-29(39)20-9-12-32-26(13-20)30(16-31)10-11-30)14-22(18)23-3-2-4-24(36-23)25-15-27(34-17-33-25)37-28(38)19-6-7-19/h2-5,8-9,12-15,17,19H,6-7,10-11H2,1H3,(H,35,39)(H,33,34,37,38) VHYVJALQXLCQLC-UHFFFAOYSA-N 745740 US12319655, Example 220 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745740 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745740&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929935 518818476 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532831 COCCNc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C29H29N7O2/c1-19-5-6-22(35-28(37)21-8-10-31-25(15-21)29(2,3)18-30)17-23(19)24-9-12-34-27(36-24)20-7-11-32-26(16-20)33-13-14-38-4/h5-12,15-17H,13-14H2,1-4H3,(H,32,33)(H,35,37) XNEKLFPBIAAQIA-UHFFFAOYSA-N 745741 US12319655, Example 221 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745741 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745741&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929609 518818477 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532835 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C31H28N6O2/c1-19-26(16-25(17-35-19)36-30(39)24-10-11-33-27(14-24)31(2,3)18-32)23-6-4-5-21(13-23)22-9-12-34-28(15-22)37-29(38)20-7-8-20/h4-6,9-17,20H,7-8H2,1-3H3,(H,36,39)(H,34,37,38) XKWJCJXPHCNTTG-UHFFFAOYSA-N 745742 US12319655, Example 222 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745742 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745742&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930637 518818478 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532839 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C32H29N5O2/c1-20-7-10-26(36-31(39)25-12-13-34-28(16-25)32(2,3)19-33)18-27(20)24-6-4-5-22(15-24)23-11-14-35-29(17-23)37-30(38)21-8-9-21/h4-7,10-18,21H,8-9H2,1-3H3,(H,36,39)(H,35,37,38) CVPOXCSMANGQHR-UHFFFAOYSA-N 745743 US12319655, Example 223 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745743 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745743&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930550 518818479 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532843 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C30H27N7O2/c1-18-4-7-23(36-29(39)20-8-9-33-26(11-20)30(2,3)16-31)12-24(18)21-10-22(15-32-14-21)25-13-27(35-17-34-25)37-28(38)19-5-6-19/h4,7-15,17,19H,5-6H2,1-3H3,(H,36,39)(H,34,35,37,38) CTHBPGHVNFAUJF-UHFFFAOYSA-N 745744 US12319655, Example 224 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745744 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745744&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929954 518818480 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532847 COC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)c2)ncn1 InChI=1S/C28H25N7O3/c1-17-22(18-6-5-7-19(10-18)23-13-25(33-16-32-23)35-27(37)38-4)12-21(14-31-17)34-26(36)20-8-9-30-24(11-20)28(2,3)15-29/h5-14,16H,1-4H3,(H,34,36)(H,32,33,35,37) OQYJGRAXXFYGEP-UHFFFAOYSA-N 745745 US12319655, Example 225 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745745 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745745&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929926 518818481 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532851 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)n1 InChI=1S/C29H26N8O2/c1-17-21(12-20(14-32-17)35-28(39)19-9-10-31-25(11-19)29(2,3)15-30)22-5-4-6-23(36-22)24-13-26(34-16-33-24)37-27(38)18-7-8-18/h4-6,9-14,16,18H,7-8H2,1-3H3,(H,35,39)(H,33,34,37,38) MUZVBNJMLYNMQQ-UHFFFAOYSA-N 745746 US12319655, Example 226 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745746 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745746&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930500 518818482 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532855 CNc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)c2)ncn1 InChI=1S/C27H25N7O/c1-17-22(18-6-5-7-19(10-18)23-13-25(29-4)33-16-32-23)12-21(14-31-17)34-26(35)20-8-9-30-24(11-20)27(2,3)15-28/h5-14,16H,1-4H3,(H,34,35)(H,29,32,33) GDGNXJBJKUKPOL-UHFFFAOYSA-N 745747 US12319655, Example 227 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745747 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745747&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930319 518818483 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532859 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C(C)(C)C)c2)c1 InChI=1S/C31H31N7O2/c1-19-24(16-23(17-36-19)37-28(39)22-9-11-34-26(14-22)31(5,6)18-32)20-7-10-33-25(13-20)21-8-12-35-27(15-21)38-29(40)30(2,3)4/h7-17H,1-6H3,(H,37,39)(H,35,38,40) BEOSOPDBBSDMFT-UHFFFAOYSA-N 745748 US12319655, Example 228 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745748 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745748&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929786 518818484 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532863 Cc1ccc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C29H26N6O2/c1-17-2-7-22(33-29(37)21-9-11-30-25(14-21)18-3-4-18)16-23(17)24-10-13-32-27(34-24)20-8-12-31-26(15-20)35-28(36)19-5-6-19/h2,7-16,18-19H,3-6H2,1H3,(H,33,37)(H,31,35,36) DTIBRRMNHUTWJN-UHFFFAOYSA-N 745749 US12319655, Example 229 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745749 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745749&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929757 518818485 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532867 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cnnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C30H27N7O2/c1-18-4-7-23(35-29(39)21-9-10-32-26(13-21)30(2,3)17-31)15-24(18)22-12-25(37-34-16-22)20-8-11-33-27(14-20)36-28(38)19-5-6-19/h4,7-16,19H,5-6H2,1-3H3,(H,35,39)(H,33,36,38) FMGFSBOGXJBZIR-UHFFFAOYSA-N 745750 US12319655, Example 230 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745750 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745750&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024593 518818486 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532871 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3C)cc(OCCO)n2)ccn1 InChI=1S/C32H31N5O4/c1-20-8-9-25(36-30(39)22-6-5-7-24(14-22)32(2,3)19-33)18-26(20)23-16-27(37-29(17-23)41-13-12-38)21-10-11-35-28(15-21)31(40)34-4/h5-11,14-18,38H,12-13H2,1-4H3,(H,34,40)(H,36,39) DDDLMZAXGMTQSE-UHFFFAOYSA-N 745751 US12319655, Example 231 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745751 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745751&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929910 518818487 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532875 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C29H27FN6O2/c1-17-4-7-21(34-28(38)20-9-11-31-24(14-20)29(2,3)30)16-22(17)26-33-13-10-23(35-26)19-8-12-32-25(15-19)36-27(37)18-5-6-18/h4,7-16,18H,5-6H2,1-3H3,(H,34,38)(H,32,36,37) NTODNVKVZKANQZ-UHFFFAOYSA-N 745752 US12319655, Example 232 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745752 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745752&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929969 518818488 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532879 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)n1 InChI=1S/C30H27N7O2/c1-18-7-10-21(35-29(39)20-11-12-32-26(13-20)30(2,3)16-31)14-22(18)23-5-4-6-24(36-23)25-15-27(34-17-33-25)37-28(38)19-8-9-19/h4-7,10-15,17,19H,8-9H2,1-3H3,(H,35,39)(H,33,34,37,38) OPXNXYCTPMVMAN-UHFFFAOYSA-N 745753 US12319655, Example 233 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745753 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745753&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929354 518818489 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532883 CNC(=O)c1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)n2)ccn1 InChI=1S/C29H26N6O2/c1-18-8-9-21(34-27(36)20-11-13-33-26(15-20)29(2,3)17-30)16-22(18)24-7-5-6-23(35-24)19-10-12-32-25(14-19)28(37)31-4/h5-16H,1-4H3,(H,31,37)(H,34,36) IQZQEAPAWWXXJT-UHFFFAOYSA-N 745754 US12319655, Example 234 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745754 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745754&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929843 518818490 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532887 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)c2)ncn1 InChI=1S/C28H25N7O2/c1-17-5-6-21(35-26(36)18-7-8-32-25(10-18)28(2,3)15-29)11-22(17)19-9-20(14-31-13-19)23-12-24(27(37)30-4)34-16-33-23/h5-14,16H,1-4H3,(H,30,37)(H,35,36) HUXDGLCWKBOYFO-UHFFFAOYSA-N 745755 US12319655, Example 235 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745755 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745755&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169938966 518818491 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532891 COC(C)(C)C(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)ccn2)ccn1 InChI=1S/C32H32N6O3/c1-20-7-8-24(37-29(39)23-11-13-35-27(16-23)31(2,3)19-33)18-25(20)21-9-12-34-26(15-21)22-10-14-36-28(17-22)38-30(40)32(4,5)41-6/h7-18H,1-6H3,(H,37,39)(H,36,38,40) WRELQIHOPKLDFT-UHFFFAOYSA-N 745756 US12319655, Example 237 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745756 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745756&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930730 518818492 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532895 COC(C)(C)c1cc(C(=O)Nc2ccc(C)c(-c3nccc(-c4ccnc(NC(=O)C5CC5)c4)n3)c2)ccn1 InChI=1S/C30H30N6O3/c1-18-5-8-22(34-29(38)21-10-12-31-25(15-21)30(2,3)39-4)17-23(18)27-33-14-11-24(35-27)20-9-13-32-26(16-20)36-28(37)19-6-7-19/h5,8-17,19H,6-7H2,1-4H3,(H,34,38)(H,32,36,37) QXXHSKOXEJARPD-UHFFFAOYSA-N 745757 US12319655, Example 239 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745757 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745757&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170098054 518818493 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532899 N#Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C31H25N7O2/c1-31(2,17-33)27-13-22(10-11-34-27)30(40)37-24-9-8-23(16-32)25(14-24)20-4-3-5-21(12-20)26-15-28(36-18-35-26)38-29(39)19-6-7-19/h3-5,8-15,18-19H,6-7H2,1-2H3,(H,37,40)(H,35,36,38,39) TZMPQMQIIFCVNH-UHFFFAOYSA-N 745758 US12319655, Example 240 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745758 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745758&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024557 518818494 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532903 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3(C#N)CC3)c2)n1 InChI=1S/C31H26N8O2/c1-19-4-5-22(37-28(40)21-7-11-34-25(14-21)30(2,3)17-32)16-23(19)24-8-13-36-27(38-24)20-6-12-35-26(15-20)39-29(41)31(18-33)9-10-31/h4-8,11-16H,9-10H2,1-3H3,(H,37,40)(H,35,39,41) MZIZTNPGLDHJOI-UHFFFAOYSA-N 745759 US12319655, Example 241 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745759 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745759&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930265 518818495 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532907 CNC(=O)c1cc(-c2ccnc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)c(F)cc3C)n2)ccn1 InChI=1S/C28H24FN7O2/c1-16-11-20(29)22(36-26(37)18-6-9-33-24(13-18)28(2,3)15-30)14-19(16)25-34-10-7-21(35-25)17-5-8-32-23(12-17)27(38)31-4/h5-14H,1-4H3,(H,31,38)(H,36,37) HWURIVYMQPNGGS-UHFFFAOYSA-N 745760 US12319655, Example 242 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745760 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745760&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929742 518818496 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532911 COC1(C(=O)Nc2cc(-c3cccc(-c4cc(NC(=O)c5ccnc(C(C)(C)C#N)c5)ccc4C)c3)ncn2)CC1 InChI=1S/C32H30N6O3/c1-20-8-9-24(37-29(39)23-10-13-34-27(15-23)31(2,3)18-33)16-25(20)21-6-5-7-22(14-21)26-17-28(36-19-35-26)38-30(40)32(41-4)11-12-32/h5-10,13-17,19H,11-12H2,1-4H3,(H,37,39)(H,35,36,38,40) RPLWNJCOHUUEKT-UHFFFAOYSA-N 745761 US12319655, Example 243 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745761 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745761&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930602 518818497 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532915 Cc1cc(F)c(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H26FN7O2/c1-17-12-22(31)24(37-29(40)20-7-9-33-25(13-20)30(2,3)16-32)15-21(17)27-35-11-8-23(36-27)19-6-10-34-26(14-19)38-28(39)18-4-5-18/h6-15,18H,4-5H2,1-3H3,(H,37,40)(H,34,38,39) XORJFZUQIKLDRS-UHFFFAOYSA-N 745762 US12319655, Example 244 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745762 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745762&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930309 518818498 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532919 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C30H27N7O2/c1-18-4-7-23(35-29(39)21-9-10-32-26(13-21)30(2,3)17-31)15-24(18)25-12-22(16-34-37-25)20-8-11-33-27(14-20)36-28(38)19-5-6-19/h4,7-16,19H,5-6H2,1-3H3,(H,35,39)(H,33,36,38) MGZMFEWOSNPMLD-UHFFFAOYSA-N 745763 US12319655, Example 245 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745763 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745763&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929648 518818499 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532923 CNC(=O)c1cc(-c2ccnc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)n2)ccn1 InChI=1S/C27H25FN6O2/c1-16-5-6-19(33-25(35)18-8-11-31-23(14-18)27(2,3)28)15-20(16)24-32-12-9-21(34-24)17-7-10-30-22(13-17)26(36)29-4/h5-15H,1-4H3,(H,29,36)(H,33,35) GXZPJOTZMXYRLW-UHFFFAOYSA-N 745764 US12319655, Example 246 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745764 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745764&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929414 518818500 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532927 N#Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(C(=O)NC)c2)c1 InChI=1S/C29H23N7O2/c1-29(2,17-31)26-14-20(8-11-35-26)27(37)36-22-5-4-21(16-30)23(15-22)18-6-9-33-24(12-18)19-7-10-34-25(13-19)28(38)32-3/h4-15H,1-3H3,(H,32,38)(H,36,37) QCTNNAKHAYQIPG-UHFFFAOYSA-N 745765 US12319655, Example 247 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745765 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745765&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930152 518818501 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532931 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3(C)CC3)c2)n1 InChI=1S/C31H29N7O2/c1-19-5-6-22(36-28(39)21-8-12-33-25(15-21)30(2,3)18-32)17-23(19)24-9-14-35-27(37-24)20-7-13-34-26(16-20)38-29(40)31(4)10-11-31/h5-9,12-17H,10-11H2,1-4H3,(H,36,39)(H,34,38,40) PVNLSUUOCZYADJ-UHFFFAOYSA-N 745766 US12319655, Example 248 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745766 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745766&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929725 518818502 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532935 Cc1ncc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C29H27FN6O2/c1-17-23(13-22(15-32-17)35-28(38)21-9-10-31-25(12-21)29(2,3)30)19-5-4-6-20(11-19)24-14-26(34-16-33-24)36-27(37)18-7-8-18/h4-6,9-16,18H,7-8H2,1-3H3,(H,35,38)(H,33,34,36,37) AKOPMSOLBYRCJU-UHFFFAOYSA-N 745767 US12319655, Example 249 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745767 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745767&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929551 518818503 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532939 Cc1ccc(NC(=O)c2cnnc(C3CC3)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C28H25N7O2/c1-16-2-7-21(32-28(37)20-12-24(17-3-4-17)35-31-15-20)14-22(16)23-9-11-30-26(33-23)19-8-10-29-25(13-19)34-27(36)18-5-6-18/h2,7-15,17-18H,3-6H2,1H3,(H,32,37)(H,29,34,36) BKDHKZIYLZCPIJ-UHFFFAOYSA-N 745768 US12319655, Example 250 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745768&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024731 518818504 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532943 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C30H27N7O2/c1-18-24(15-23(16-35-18)36-29(39)22-8-10-33-26(13-22)30(2,3)17-31)20-6-9-32-25(12-20)21-7-11-34-27(14-21)37-28(38)19-4-5-19/h6-16,19H,4-5H2,1-3H3,(H,36,39)(H,34,37,38) UHKOAFBNVPTJKM-UHFFFAOYSA-N 745769 US12319655, Example 251 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745769 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745769&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930574 518818505 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532947 Cc1cc(F)c(NC(=O)c2cnnc(C3CC3)c2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C28H24FN7O2/c1-15-10-21(29)24(34-28(38)19-11-23(16-2-3-16)36-32-14-19)13-20(15)26-31-9-7-22(33-26)18-6-8-30-25(12-18)35-27(37)17-4-5-17/h6-14,16-17H,2-5H2,1H3,(H,34,38)(H,30,35,37) PLOQYOXNQXJZOT-UHFFFAOYSA-N 745770 US12319655, Example 252 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745770 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745770&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024554 518818506 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532951 Cc1ncc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C29H26N6O2/c1-17-24(15-23(16-33-17)34-29(37)22-8-10-30-25(13-22)18-2-3-18)20-6-9-31-26(12-20)21-7-11-32-27(14-21)35-28(36)19-4-5-19/h6-16,18-19H,2-5H2,1H3,(H,34,37)(H,32,35,36) LHTBPZAFJSOTJJ-UHFFFAOYSA-N 745771 US12319655, Example 253 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745771 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745771&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930518 518818507 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532955 Cc1ncc(NC(=O)c2cnnc(C3CC3)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C28H25N7O2/c1-16-23(13-22(15-31-16)33-28(37)21-11-25(17-2-3-17)35-32-14-21)19-6-8-29-24(10-19)20-7-9-30-26(12-20)34-27(36)18-4-5-18/h6-15,17-18H,2-5H2,1H3,(H,33,37)(H,30,34,36) WDCMFAUTUPYPHJ-UHFFFAOYSA-N 745772 US12319655, Example 254 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745772 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745772&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930469 518818508 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532959 Cc1ccc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C30H27N5O2/c1-18-5-10-24(34-30(37)23-11-12-31-26(14-23)19-6-7-19)15-25(18)21-3-2-4-22(13-21)27-16-28(33-17-32-27)35-29(36)20-8-9-20/h2-5,10-17,19-20H,6-9H2,1H3,(H,34,37)(H,32,33,35,36) WEGDWZMHIBWSOB-UHFFFAOYSA-N 745773 US12319655, Example 255 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745773 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745773&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930537 518818509 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532963 Cc1ncc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1cnc(C)c(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C30H28N6O2/c1-17-25(21-7-10-32-28(13-21)36-29(37)20-5-6-20)11-23(15-33-17)26-14-24(16-34-18(26)2)35-30(38)22-8-9-31-27(12-22)19-3-4-19/h7-16,19-20H,3-6H2,1-2H3,(H,35,38)(H,32,36,37) BWSNNBBRETWDHL-UHFFFAOYSA-N 745774 US12319655, Example 256 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745774 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745774&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929625 518818510 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532967 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H27N7O2/c1-18-4-7-22(35-29(39)21-9-11-32-25(14-21)30(2,3)17-31)16-23(18)24-10-13-34-27(36-24)20-8-12-33-26(15-20)37-28(38)19-5-6-19/h4,7-16,19H,5-6H2,1-3H3,(H,35,39)(H,33,37,38) KHRXRBAAQAGPGI-UHFFFAOYSA-N 745775 US12319655, Example 257 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745775 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745775&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930124 518818511 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532971 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ccnc(NC3CN(C)C3)c2)c1 InChI=1S/C32H32N6O/c1-21-8-9-26(37-31(39)25-11-12-34-29(15-25)32(2,3)20-33)17-28(21)24-7-5-6-22(14-24)23-10-13-35-30(16-23)36-27-18-38(4)19-27/h5-17,27H,18-19H2,1-4H3,(H,35,36)(H,37,39) GONHEKMALZOUGS-UHFFFAOYSA-N 745776 US12319655, Example 258 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745776 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745776&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024750 518818512 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532975 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3F)cc(C)n2)ccn1 InChI=1S/C29H25FN6O2/c1-17-11-20(13-24(35-17)18-7-9-33-25(12-18)28(38)32-4)22-15-21(5-6-23(22)30)36-27(37)19-8-10-34-26(14-19)29(2,3)16-31/h5-15H,1-4H3,(H,32,38)(H,36,37) OJUZBOJXIPXYLJ-UHFFFAOYSA-N 745777 US12319655, Example 259 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745777 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745777&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024632 518818513 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532979 CCOc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)C#N)c3)ccc2C)cc1-c1ccnc(C(=O)NC)c1 InChI=1S/C31H30N6O3/c1-6-40-30-25(20-9-11-34-26(14-20)29(39)33-5)13-22(17-36-30)24-16-23(8-7-19(24)2)37-28(38)21-10-12-35-27(15-21)31(3,4)18-32/h7-17H,6H2,1-5H3,(H,33,39)(H,37,38) YPMFUIKYHUJTPU-UHFFFAOYSA-N 745778 US12319655, Example 260 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745778 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745778&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929826 518818514 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532983 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)CN)c2)n1 InChI=1S/C28H26N8O2/c1-17-4-5-20(34-27(38)19-7-9-31-23(12-19)28(2,3)16-30)14-21(17)22-8-11-33-26(35-22)18-6-10-32-24(13-18)36-25(37)15-29/h4-14H,15,29H2,1-3H3,(H,34,38)(H,32,36,37) GZHDTCLLOHTJIM-UHFFFAOYSA-N 745779 US12319655, Example 261 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745779 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745779&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024745 518818515 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532987 Cc1cc(F)c(NC(=O)c2ccnc(C3(C#N)CC3)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H24FN7O2/c1-17-12-22(31)24(37-29(40)20-5-9-33-25(13-20)30(16-32)7-8-30)15-21(17)23-6-11-35-27(36-23)19-4-10-34-26(14-19)38-28(39)18-2-3-18/h4-6,9-15,18H,2-3,7-8H2,1H3,(H,37,40)(H,34,38,39) COTBIGBFTAUBRP-UHFFFAOYSA-N 745780 US12319655, Example 262 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745780&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929928 518818516 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532991 Cc1cc(F)c(NC(=O)c2cnnc(C3CC3)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C28H24FN7O2/c1-15-10-21(29)24(34-28(38)19-11-23(16-2-3-16)36-32-14-19)13-20(15)22-7-9-31-26(33-22)18-6-8-30-25(12-18)35-27(37)17-4-5-17/h6-14,16-17H,2-5H2,1H3,(H,34,38)(H,30,35,37) ZEGXTAUOHZHVDB-UHFFFAOYSA-N 745781 US12319655, Example 263 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745781 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745781&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930348 518818517 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532995 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)OC)c4)ccc3C)ccn2)ccn1 InChI=1S/C29H29N5O3/c1-18-6-7-22(34-27(35)21-10-13-33-26(16-21)29(2,3)37-5)17-23(18)19-8-11-31-24(14-19)20-9-12-32-25(15-20)28(36)30-4/h6-17H,1-5H3,(H,30,36)(H,34,35) KOAYIWSIXGIKBG-UHFFFAOYSA-N 745782 US12319655, Example 264 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745782 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745782&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930236 518818518 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1532999 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C5(C#N)CC5)c4)ccc3C)ccn2)ccn1 InChI=1S/C29H24N6O2/c1-18-3-4-22(35-27(36)21-7-12-34-26(15-21)29(17-30)8-9-29)16-23(18)19-5-10-32-24(13-19)20-6-11-33-25(14-20)28(37)31-2/h3-7,10-16H,8-9H2,1-2H3,(H,31,37)(H,35,36) ZPCSOZHQWTXFMP-UHFFFAOYSA-N 745783 US12319655, Example 265 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745783&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169939296 518818519 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533003 CCNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)ccn2)ccn1 InChI=1S/C30H28N6O2/c1-5-32-29(38)26-15-21(9-12-34-26)25-14-20(8-11-33-25)24-17-23(7-6-19(24)2)36-28(37)22-10-13-35-27(16-22)30(3,4)18-31/h6-17H,5H2,1-4H3,(H,32,38)(H,36,37) CJNKEJJHTPIXHW-UHFFFAOYSA-N 745784 US12319655, Example 266 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745784 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745784&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930292 518818520 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533007 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(N)ncn2)c1 InChI=1S/C27H24N6O/c1-17-7-8-21(33-26(34)20-9-10-30-24(12-20)27(2,3)15-28)13-22(17)18-5-4-6-19(11-18)23-14-25(29)32-16-31-23/h4-14,16H,1-3H3,(H,33,34)(H2,29,31,32) UTCPVJSIQCHFGS-UHFFFAOYSA-N 745785 US12319655, Example 267 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745785 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745785&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929699 518818521 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533011 CNC(=O)c1cc(-c2ccnc(-c3cc(NC(=O)c4ccnc(C(C)(C)OC)c4)ccc3C)n2)ccn1 InChI=1S/C28H28N6O3/c1-17-6-7-20(33-26(35)19-9-12-31-24(15-19)28(2,3)37-5)16-21(17)25-32-13-10-22(34-25)18-8-11-30-23(14-18)27(36)29-4/h6-16H,1-5H3,(H,29,36)(H,33,35) ALPUDZXEJCTQRD-UHFFFAOYSA-N 745786 US12319655, Example 268 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745786 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745786&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929626 518818522 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533015 Cc1ncc(NC(=O)c2ccnc(C(C)C)c2)cc1-c1cccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C29H28N6O2/c1-17(2)26-13-21(10-11-30-26)29(37)33-22-15-23(18(3)32-16-22)25-6-4-5-24(34-25)20-9-12-31-27(14-20)35-28(36)19-7-8-19/h4-6,9-17,19H,7-8H2,1-3H3,(H,33,37)(H,31,35,36) JZCOAOKRTGMFOF-UHFFFAOYSA-N 745787 US12319655, Example 269 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745787 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745787&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929941 518818523 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533019 Cc1ncc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1cccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C29H26N6O2/c1-17-23(15-22(16-32-17)33-29(37)21-10-11-30-26(13-21)18-5-6-18)25-4-2-3-24(34-25)20-9-12-31-27(14-20)35-28(36)19-7-8-19/h2-4,9-16,18-19H,5-8H2,1H3,(H,33,37)(H,31,35,36) YWEABIXQKUPBKM-UHFFFAOYSA-N 745788 US12319655, Example 270 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745788 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745788&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929666 518818524 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533023 Cc1cc(F)c(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C27H20F4N6O2/c1-14-8-19(28)20(36-26(39)17-5-6-33-23(9-17)27(29,30)31)11-18(14)22-13-32-12-21(35-22)16-4-7-34-24(10-16)37-25(38)15-2-3-15/h4-13,15H,2-3H2,1H3,(H,36,39)(H,34,37,38) QHDAFRDXFNYBOZ-UHFFFAOYSA-N 745789 US12319655, Example 271 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745789 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745789&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929837 518818525 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533027 Cc1ccc(NC(=O)c2cnnc(C3CC3)c2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C28H25N7O2/c1-16-2-7-21(32-28(37)20-12-24(17-3-4-17)35-31-15-20)14-22(16)26-30-11-9-23(33-26)19-8-10-29-25(13-19)34-27(36)18-5-6-18/h2,7-15,17-18H,3-6H2,1H3,(H,32,37)(H,29,34,36) PWIPUNMDGJCKSH-UHFFFAOYSA-N 745790 US12319655, Example 272 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745790 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745790&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024624 518818526 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533031 Cc1cc(C(=O)Nc2cnc(C)c(-c3ccnc(-c4ccnc(NC(=O)C5CC5)c4)n3)c2)ccn1 InChI=1S/C26H23N7O2/c1-15-11-19(6-8-27-15)26(35)31-20-13-21(16(2)30-14-20)22-7-10-29-24(32-22)18-5-9-28-23(12-18)33-25(34)17-3-4-17/h5-14,17H,3-4H2,1-2H3,(H,31,35)(H,28,33,34) NFUHXLBCKYIOAK-UHFFFAOYSA-N 745791 US12319655, Example 273 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745791 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745791&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930101 518818527 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533035 COC(C)(C)c1cc(C(=O)Nc2cnc(C)c(-c3cccc(-c4cc(NC(=O)C5CC5)ncn4)c3)c2)ccn1 InChI=1S/C30H30N6O3/c1-18-24(14-23(16-32-18)35-29(38)22-10-11-31-26(13-22)30(2,3)39-4)20-6-5-7-21(12-20)25-15-27(34-17-33-25)36-28(37)19-8-9-19/h5-7,10-17,19H,8-9H2,1-4H3,(H,35,38)(H,33,34,36,37) KABCFVWXVOWEHF-UHFFFAOYSA-N 745792 US12319655, Example 274 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745792 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745792&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929430 518818528 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533039 Cc1cc(F)c(NC(=O)c2ccnc(C(F)F)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C27H21F3N6O2/c1-14-8-19(28)20(35-27(38)17-5-6-32-21(9-17)25(29)30)11-18(14)23-13-31-12-22(34-23)16-4-7-33-24(10-16)36-26(37)15-2-3-15/h4-13,15,25H,2-3H2,1H3,(H,35,38)(H,33,36,37) XWOFHKVNBLFYGJ-UHFFFAOYSA-N 745793 US12319655, Example 275 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745793 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745793&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930169 518818529 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533043 Cc1cc(F)c(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C29H26F2N6O2/c1-16-10-21(30)22(36-28(39)19-7-8-33-25(11-19)29(2,3)31)13-20(16)24-15-32-14-23(35-24)18-6-9-34-26(12-18)37-27(38)17-4-5-17/h6-15,17H,4-5H2,1-3H3,(H,36,39)(H,34,37,38) JAMROQLPUOKJOQ-UHFFFAOYSA-N 745794 US12319655, Example 276 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745794 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745794&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929534 518818530 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533047 Cc1ncc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C28H25N7O2/c1-16-22(14-21(15-32-16)33-28(37)20-7-9-29-24(12-20)17-2-3-17)23-8-11-31-26(34-23)19-6-10-30-25(13-19)35-27(36)18-4-5-18/h6-15,17-18H,2-5H2,1H3,(H,33,37)(H,30,35,36) RXQJXJNQASNMRG-UHFFFAOYSA-N 745795 US12319655, Example 277 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745795&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929931 518818531 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533051 Cc1ncc(NC(=O)c2cnnc(C3CC3)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C27H24N8O2/c1-15-21(12-20(14-30-15)32-27(37)19-10-23(16-2-3-16)35-31-13-19)22-7-9-29-25(33-22)18-6-8-28-24(11-18)34-26(36)17-4-5-17/h6-14,16-17H,2-5H2,1H3,(H,32,37)(H,28,34,36) CKGCYTYALJWIJO-UHFFFAOYSA-N 745796 US12319655, Example 278 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745796 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745796&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929347 518818532 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533055 Cc1ncc(NC(=O)c2cnn(C(C)(C)C)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C28H29N7O2/c1-17-23(11-22(14-29-17)33-27(37)21-13-32-35(15-21)28(2,3)4)19-6-5-7-20(10-19)24-12-25(31-16-30-24)34-26(36)18-8-9-18/h5-7,10-16,18H,8-9H2,1-4H3,(H,33,37)(H,30,31,34,36) YVDLMHMBXQQKIW-UHFFFAOYSA-N 745797 US12319655, Example 279 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745797 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745797&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930375 518818533 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533059 Cc1ncc(NC(=O)c2cncc(C(F)F)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C27H22F2N6O2/c1-15-22(9-21(13-31-15)34-27(37)20-8-19(25(28)29)11-30-12-20)17-3-2-4-18(7-17)23-10-24(33-14-32-23)35-26(36)16-5-6-16/h2-4,7-14,16,25H,5-6H2,1H3,(H,34,37)(H,32,33,35,36) QXSQVOHMTQPEDA-UHFFFAOYSA-N 745798 US12319655, Example 280 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745798 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745798&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024717 518818534 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533063 Cc1ncc(NC(=O)c2cn(C(C)C)nn2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C25H25N9O2/c1-14(2)34-13-21(32-33-34)25(36)29-18-11-19(15(3)28-12-18)20-7-9-27-23(30-20)17-6-8-26-22(10-17)31-24(35)16-4-5-16/h6-14,16H,4-5H2,1-3H3,(H,29,36)(H,26,31,35) XXZNASURMCKQTJ-UHFFFAOYSA-N 745799 US12319655, Example 281 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745799 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745799&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024543 518818535 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533067 COC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)c2)ccn1 InChI=1S/C29H26N6O3/c1-18-24(21-7-5-6-19(12-21)20-8-11-32-26(14-20)35-28(37)38-4)15-23(16-33-18)34-27(36)22-9-10-31-25(13-22)29(2,3)17-30/h5-16H,1-4H3,(H,34,36)(H,32,35,37) FMTCCJFEKALEOF-UHFFFAOYSA-N 745800 US12319655, Example 282 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745800 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745800&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930714 518818536 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533071 Cc1ncc(NC(=O)c2cnn(C(C)(C)C)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C27H28N8O2/c1-16-21(12-20(14-30-16)32-26(37)19-13-31-35(15-19)27(2,3)4)22-8-10-29-24(33-22)18-7-9-28-23(11-18)34-25(36)17-5-6-17/h7-15,17H,5-6H2,1-4H3,(H,32,37)(H,28,34,36) XQKSJZYJYBGSRA-UHFFFAOYSA-N 745801 US12319655, Example 283 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745801 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745801&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929684 518818537 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533079 Cc1ncc(NC(=O)c2cn(C(C)C)nn2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C25H25N9O2/c1-14(2)34-13-21(32-33-34)25(36)29-18-11-19(15(3)28-12-18)23-27-9-7-20(30-23)17-6-8-26-22(10-17)31-24(35)16-4-5-16/h6-14,16H,4-5H2,1-3H3,(H,29,36)(H,26,31,35) BGGQXCGOYKRLPG-UHFFFAOYSA-N 745803 US12319655, Example 285 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745803 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745803&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930717 518818539 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533083 Cc1nc(-c2ccnc(NC(=O)C3CC3)c2)cc(-c2cc(NC(=O)c3ccnc(C4(C#N)CC4)c3)cnc2C)n1 InChI=1S/C30H26N8O2/c1-17-23(13-22(15-34-17)37-29(40)21-6-9-32-26(11-21)30(16-31)7-8-30)25-14-24(35-18(2)36-25)20-5-10-33-27(12-20)38-28(39)19-3-4-19/h5-6,9-15,19H,3-4,7-8H2,1-2H3,(H,37,40)(H,33,38,39) WEOUTSJUVSACSQ-UHFFFAOYSA-N 745804 US12319655, Example 286 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745804 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745804&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930678 518818540 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533087 Cc1nc(-c2ccnc(NC(=O)C3CC3)c2)cc(-c2cc(NC(=O)c3ccnc(C4CC4)c3)cnc2C)n1 InChI=1S/C29H27N7O2/c1-16-23(13-22(15-32-16)35-29(38)21-8-9-30-24(11-21)18-3-4-18)26-14-25(33-17(2)34-26)20-7-10-31-27(12-20)36-28(37)19-5-6-19/h7-15,18-19H,3-6H2,1-2H3,(H,35,38)(H,31,36,37) HEVFCJPAJVEFKO-UHFFFAOYSA-N 745805 US12319655, Example 287 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745805&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024592 518818541 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533091 COC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C5CC5)c4)cnc3C)c2)ccn1 InChI=1S/C28H25N5O3/c1-17-24(15-23(16-31-17)32-27(34)22-9-10-29-25(13-22)18-6-7-18)21-5-3-4-19(12-21)20-8-11-30-26(14-20)33-28(35)36-2/h3-5,8-16,18H,6-7H2,1-2H3,(H,32,34)(H,30,33,35) SAAPXMWMYUVAAV-UHFFFAOYSA-N 745806 US12319655, Example 288 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745806 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745806&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930589 518818542 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533095 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ccnc(N)n2)c1 InChI=1S/C26H23N7O/c1-16-21(17-5-4-6-18(11-17)22-8-10-30-25(28)33-22)13-20(14-31-16)32-24(34)19-7-9-29-23(12-19)26(2,3)15-27/h4-14H,1-3H3,(H,32,34)(H2,28,30,33) BWCDHAIBCZGKMV-UHFFFAOYSA-N 745807 US12319655, Example 289 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745807 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745807&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930131 518818543 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533099 COC(=O)Nc1nccc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)c2)n1 InChI=1S/C28H25N7O3/c1-17-22(18-6-5-7-19(12-18)23-9-11-31-26(34-23)35-27(37)38-4)14-21(15-32-17)33-25(36)20-8-10-30-24(13-20)28(2,3)16-29/h5-15H,1-4H3,(H,33,36)(H,31,34,35,37) ZUMMVSUTCJOREU-UHFFFAOYSA-N 745808 US12319655, Example 290 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745808 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745808&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930368 518818544 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533103 Cc1ncc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C29H26N6O2/c1-17-24(13-23(15-31-17)34-29(37)22-9-10-30-25(12-22)18-5-6-18)20-3-2-4-21(11-20)26-14-27(33-16-32-26)35-28(36)19-7-8-19/h2-4,9-16,18-19H,5-8H2,1H3,(H,34,37)(H,32,33,35,36) YXRZICMQCBWPQC-UHFFFAOYSA-N 745809 US12319655, Example 291 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745809 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745809&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930498 518818545 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533107 Cc1ncc(NC(=O)C2=CC(C(C)C)N=N2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C27H27N7O2/c1-15(2)22-11-24(34-33-22)27(36)31-20-10-21(16(3)28-13-20)18-5-4-6-19(9-18)23-12-25(30-14-29-23)32-26(35)17-7-8-17/h4-6,9-15,17,22H,7-8H2,1-3H3,(H,31,36)(H,29,30,32,35) NAETVEKVWNMSPH-UHFFFAOYSA-N 745810 US12319655, Example 292 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745810 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745810&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024650 518818546 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533111 Cc1ncc(NC(=O)c2ccnc(C3(C#N)CC3)c2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C29H24N8O2/c1-17-22(14-21(15-34-17)35-28(39)20-5-9-31-24(12-20)29(16-30)7-8-29)26-33-11-6-23(36-26)19-4-10-32-25(13-19)37-27(38)18-2-3-18/h4-6,9-15,18H,2-3,7-8H2,1H3,(H,35,39)(H,32,37,38) GANLWRXJRNUOJG-UHFFFAOYSA-N 745811 US12319655, Example 293 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745811 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745811&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929567 518818547 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533115 Cc1ncc(NC(=O)c2cnnc(C3CC3)c2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C27H24N8O2/c1-15-21(12-20(14-30-15)32-27(37)19-10-23(16-2-3-16)35-31-13-19)25-29-9-7-22(33-25)18-6-8-28-24(11-18)34-26(36)17-4-5-17/h6-14,16-17H,2-5H2,1H3,(H,32,37)(H,28,34,36) CHJYWIAESSMVIR-UHFFFAOYSA-N 745812 US12319655, Example 294 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745812 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745812&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930718 518818548 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533119 Cc1ncc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C28H25N7O2/c1-16-22(14-21(15-32-16)33-28(37)20-7-9-29-24(12-20)17-2-3-17)26-31-11-8-23(34-26)19-6-10-30-25(13-19)35-27(36)18-4-5-18/h6-15,17-18H,2-5H2,1H3,(H,33,37)(H,30,35,36) ZUBJVFKYAXEWQI-UHFFFAOYSA-N 745813 US12319655, Example 295 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745813 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745813&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930606 518818549 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533123 Cc1cc(C(=O)Nc2cnc(C)c(-c3nccc(-c4ccnc(NC(=O)C5CC5)c4)n3)c2)ccn1 InChI=1S/C26H23N7O2/c1-15-11-19(6-8-27-15)26(35)31-20-13-21(16(2)30-14-20)24-29-10-7-22(32-24)18-5-9-28-23(12-18)33-25(34)17-3-4-17/h5-14,17H,3-4H2,1-2H3,(H,31,35)(H,28,33,34) MUYSFELQXQFJEW-UHFFFAOYSA-N 745814 US12319655, Example 296 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745814 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745814&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930523 518818550 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533127 COC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)ccn2)ccn1 InChI=1S/C28H25N7O3/c1-17-22(18-5-8-30-23(11-18)19-6-10-32-25(13-19)35-27(37)38-4)14-21(15-33-17)34-26(36)20-7-9-31-24(12-20)28(2,3)16-29/h5-15H,1-4H3,(H,34,36)(H,32,35,37) CRNFAJOZEYTBIQ-UHFFFAOYSA-N 745815 US12319655, Example 297 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745815 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745815&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929893 518818551 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533131 Cc1cc(F)c(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C30H26FN7O2/c1-17-10-23(31)25(36-29(40)20-7-8-33-26(12-20)30(2,3)16-32)14-22(17)24-11-21(15-35-38-24)19-6-9-34-27(13-19)37-28(39)18-4-5-18/h6-15,18H,4-5H2,1-3H3,(H,36,40)(H,34,37,39) RCHLLCWHIGZMFI-UHFFFAOYSA-N 745816 US12319655, Example 298 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745816 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745816&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024743 518818552 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533135 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)c(F)cc3C)c2)ccn1 InChI=1S/C28H24FN7O3/c1-16-9-21(29)23(34-26(37)18-6-7-31-24(11-18)28(2,3)15-30)13-20(16)22-10-19(14-33-36-22)17-5-8-32-25(12-17)35-27(38)39-4/h5-14H,1-4H3,(H,34,37)(H,32,35,38) HVPBVBXSXFYDNN-UHFFFAOYSA-N 745817 US12319655, Example 299 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745817 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745817&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930209 518818553 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533139 Cc1cc(F)c(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C30H27F2N5O2/c1-17-12-23(31)25(36-29(39)21-8-10-34-26(14-21)30(2,3)32)16-22(17)19-6-9-33-24(13-19)20-7-11-35-27(15-20)37-28(38)18-4-5-18/h6-16,18H,4-5H2,1-3H3,(H,36,39)(H,35,37,38) LISXLOIVRKYNAD-UHFFFAOYSA-N 745818 US12319655, Example 300 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745818 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745818&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930261 518818554 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533143 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ccnc(C(N)=O)c2)c1 InChI=1S/C28H24N6O2/c1-17-23(20-6-4-5-18(11-20)19-7-9-31-24(12-19)26(30)35)14-22(15-33-17)34-27(36)21-8-10-32-25(13-21)28(2,3)16-29/h4-15H,1-3H3,(H2,30,35)(H,34,36) LXXIVCKKEKLTSC-UHFFFAOYSA-N 745819 US12319655, Example 301 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745819&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930230 518818555 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533147 COC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)c(F)cc3C)ccn2)ccn1 InChI=1S/C28H25F2N5O3/c1-16-11-21(29)23(34-26(36)19-7-9-32-24(13-19)28(2,3)30)15-20(16)17-5-8-31-22(12-17)18-6-10-33-25(14-18)35-27(37)38-4/h5-15H,1-4H3,(H,34,36)(H,33,35,37) MLKQTRPTPBHNBA-UHFFFAOYSA-N 745820 US12319655, Example 302 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745820 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745820&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930393 518818556 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533151 COC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)c(F)cc3C)n2)ccn1 InChI=1S/C28H24FN7O3/c1-16-11-20(29)22(35-26(37)18-6-8-31-23(12-18)28(2,3)15-30)14-19(16)21-7-10-33-25(34-21)17-5-9-32-24(13-17)36-27(38)39-4/h5-14H,1-4H3,(H,35,37)(H,32,36,38) DXERNQCOBVMTPO-UHFFFAOYSA-N 745821 US12319655, Example 303 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745821 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745821&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930276 518818557 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533155 COC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)c(F)cc3C)n2)ccn1 InChI=1S/C27H24F2N6O3/c1-15-11-19(28)21(34-25(36)17-6-8-30-22(12-17)27(2,3)29)14-18(15)20-7-10-32-24(33-20)16-5-9-31-23(13-16)35-26(37)38-4/h5-14H,1-4H3,(H,34,36)(H,31,35,37) OSTBFOZQSXPBOD-UHFFFAOYSA-N 745822 US12319655, Example 304 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745822 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745822&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930012 518818558 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533159 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)c2)ccn1 InChI=1S/C28H25N7O3/c1-17-5-6-21(33-26(36)19-8-9-30-24(12-19)28(2,3)16-29)14-22(17)23-11-20(15-32-35-23)18-7-10-31-25(13-18)34-27(37)38-4/h5-15H,1-4H3,(H,33,36)(H,31,34,37) NNASOYOIZHPKBM-UHFFFAOYSA-N 745823 US12319655, Example 305 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745823&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024542 518818559 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533163 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)c2)ccn1 InChI=1S/C27H24N8O3/c1-16-21(22-9-19(13-32-35-22)17-5-8-30-24(11-17)34-26(37)38-4)12-20(14-31-16)33-25(36)18-6-7-29-23(10-18)27(2,3)15-28/h5-14H,1-4H3,(H,33,36)(H,30,34,37) HWBBJFXUFZGEJI-UHFFFAOYSA-N 745824 US12319655, Example 306 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745824 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745824&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930541 518818560 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533167 Cc1cc(F)c(NC(=O)c2ccnc(C(F)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C28H22F3N5O2/c1-15-10-21(29)23(35-28(38)19-6-8-33-24(12-19)26(30)31)14-20(15)17-4-7-32-22(11-17)18-5-9-34-25(13-18)36-27(37)16-2-3-16/h4-14,16,26H,2-3H2,1H3,(H,35,38)(H,34,36,37) ADJRSIWILKXFQK-UHFFFAOYSA-N 745825 US12319655, Example 307 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745825 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745825&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930526 518818561 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533171 COC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)c(F)cc3C)ccn2)ccn1 InChI=1S/C29H25FN6O3/c1-17-11-22(30)24(35-27(37)20-7-9-33-25(13-20)29(2,3)16-31)15-21(17)18-5-8-32-23(12-18)19-6-10-34-26(14-19)36-28(38)39-4/h5-15H,1-4H3,(H,35,37)(H,34,36,38) SPIHARJIUOSIKV-UHFFFAOYSA-N 745826 US12319655, Example 308 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745826 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745826&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930487 518818562 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533175 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)cnc3C)c2)ccn1 InChI=1S/C26H24FN7O2/c1-15-20(21-10-18(13-32-34-21)16-5-7-29-22(9-16)25(36)28-4)12-19(14-31-15)33-24(35)17-6-8-30-23(11-17)26(2,3)27/h5-14H,1-4H3,(H,28,36)(H,33,35) HHJCQBJTESEGTF-UHFFFAOYSA-N 745827 US12319655, Example 309 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745827&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170100895 518818563 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533179 Cc1ncc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C28H26FN7O2/c1-16-22(13-21(15-32-16)34-27(38)19-7-8-30-24(11-19)28(2,3)29)23-10-20(14-33-36-23)18-6-9-31-25(12-18)35-26(37)17-4-5-17/h6-15,17H,4-5H2,1-3H3,(H,34,38)(H,31,35,37) VSHWZEKCRUALOU-UHFFFAOYSA-N 745828 US12319655, Example 310 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745828 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745828&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024642 518818564 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533183 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3C)c2)ccn1 InChI=1S/C29H26N6O3/c1-18-8-9-23(33-27(36)20-6-5-7-22(12-20)29(2,3)17-30)15-24(18)25-13-21(16-32-35-25)19-10-11-31-26(14-19)34-28(37)38-4/h5-16H,1-4H3,(H,33,36)(H,31,34,37) ZAYHGSKEHBNRLX-UHFFFAOYSA-N 745829 US12319655, Example 311 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745829 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745829&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024661 518818565 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533187 COC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)cnc3C)ccn2)ccn1 InChI=1S/C25H19F3N6O3/c1-14-19(12-18(13-32-14)33-23(35)17-5-7-30-21(10-17)25(26,27)28)15-3-6-29-20(9-15)16-4-8-31-22(11-16)34-24(36)37-2/h3-13H,1-2H3,(H,33,35)(H,31,34,36) WKLLKOUFLCHANS-UHFFFAOYSA-N 745830 US12319655, Example 312 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745830 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745830&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929393 518818566 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533191 COC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(F)F)c4)cnc3C)ccn2)ccn1 InChI=1S/C25H20F2N6O3/c1-14-19(12-18(13-31-14)32-24(34)17-5-7-29-21(10-17)23(26)27)15-3-6-28-20(9-15)16-4-8-30-22(11-16)33-25(35)36-2/h3-13,23H,1-2H3,(H,32,34)(H,30,33,35) OLIZQQIVABSOQE-UHFFFAOYSA-N 745831 US12319655, Example 313 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745831 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745831&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929407 518818567 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533195 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)c2)ccn1 InChI=1S/C28H25N7O2/c1-17-5-6-21(34-26(36)19-8-10-32-25(13-19)28(2,3)16-29)14-22(17)23-12-20(15-33-35-23)18-7-9-31-24(11-18)27(37)30-4/h5-15H,1-4H3,(H,30,37)(H,34,36) FFCMSXCGECJYPU-UHFFFAOYSA-N 745832 US12319655, Example 314 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745832 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745832&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929277 518818568 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533199 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C29H27FN6O2/c1-17-4-7-22(34-28(38)20-9-10-31-25(13-20)29(2,3)30)15-23(17)24-12-21(16-33-36-24)19-8-11-32-26(14-19)35-27(37)18-5-6-18/h4,7-16,18H,5-6H2,1-3H3,(H,34,38)(H,32,35,37) VZBUZMNSIDWSNN-UHFFFAOYSA-N 745833 US12319655, Example 315 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745833 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745833&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929967 518818569 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533203 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)cnc3C)c2)ccn1 InChI=1S/C27H24N8O2/c1-16-21(22-10-19(13-33-35-22)17-5-7-30-23(9-17)26(37)29-4)12-20(14-32-16)34-25(36)18-6-8-31-24(11-18)27(2,3)15-28/h5-14H,1-4H3,(H,29,37)(H,34,36) XXSKDPOLWBSHSP-UHFFFAOYSA-N 745834 US12319655, Example 316 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745834 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745834&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170100873 518818570 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533207 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C5CC5)c4)cnc3C)c2)ccn1 InChI=1S/C26H23N7O2/c1-15-21(23-11-19(13-31-33-23)17-5-7-29-24(9-17)26(35)27-2)12-20(14-30-15)32-25(34)18-6-8-28-22(10-18)16-3-4-16/h5-14,16H,3-4H2,1-2H3,(H,27,35)(H,32,34) USVQWWRLWYRALP-UHFFFAOYSA-N 745835 US12319655, Example 317 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745835 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745835&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170100846 518818571 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533211 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)cnc3C)c2)ccn1 InChI=1S/C24H18F3N7O2/c1-13-18(19-8-16(11-32-34-19)14-3-5-29-20(7-14)23(36)28-2)10-17(12-31-13)33-22(35)15-4-6-30-21(9-15)24(25,26)27/h3-12H,1-2H3,(H,28,36)(H,33,35) BSOKUAYXAZFAGR-UHFFFAOYSA-N 745836 US12319655, Example 318 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745836 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745836&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170100845 518818572 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533215 COC(C)(C)c1cc(C(=O)Nc2ccc(C)c(-c3cc(-c4ccnc(NC(=O)C5CC5)c4)cnn3)c2)ccn1 InChI=1S/C30H30N6O3/c1-18-5-8-23(34-29(38)21-10-11-31-26(14-21)30(2,3)39-4)16-24(18)25-13-22(17-33-36-25)20-9-12-32-27(15-20)35-28(37)19-6-7-19/h5,8-17,19H,6-7H2,1-4H3,(H,34,38)(H,32,35,37) WSXZUKRZCFBTHS-UHFFFAOYSA-N 745837 US12319655, Example 319 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745837 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745837&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930140 518818573 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533219 Cc1ccc(NC(=O)c2cn(C(C)C)nn2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C26H26N8O2/c1-15(2)34-14-23(32-33-34)26(36)29-20-7-4-16(3)21(12-20)22-10-19(13-28-31-22)18-8-9-27-24(11-18)30-25(35)17-5-6-17/h4,7-15,17H,5-6H2,1-3H3,(H,29,36)(H,27,30,35) PWHJWIKKAFKWPR-UHFFFAOYSA-N 745838 US12319655, Example 320 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745838 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745838&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930179 518818574 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533223 Cc1ccc(NC(=O)c2cnn(C(C)(C)C)c2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C28H29N7O2/c1-17-5-8-22(32-27(37)21-15-31-35(16-21)28(2,3)4)13-23(17)24-11-20(14-30-34-24)19-9-10-29-25(12-19)33-26(36)18-6-7-18/h5,8-16,18H,6-7H2,1-4H3,(H,32,37)(H,29,33,36) QGIYPTUZVGUDMP-UHFFFAOYSA-N 745839 US12319655, Example 321 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745839 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745839&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930151 518818575 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533227 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccc(Cl)c(OC)c4)cnc3C)c2)ccn1 InChI=1S/C25H21ClN6O3/c1-14-19(11-18(13-29-14)31-24(33)16-4-5-20(26)23(10-16)35-3)21-9-17(12-30-32-21)15-6-7-28-22(8-15)25(34)27-2/h4-13H,1-3H3,(H,27,34)(H,31,33) OUCKXYGABPFBIU-UHFFFAOYSA-N 745840 US12319655, Example 322 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745840 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745840&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169944253 518818576 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533231 COC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)cnc3C)ccn2)ccn1 InChI=1S/C27H25FN6O3/c1-16-21(14-20(15-32-16)33-25(35)19-7-9-30-23(12-19)27(2,3)28)17-5-8-29-22(11-17)18-6-10-31-24(13-18)34-26(36)37-4/h5-15H,1-4H3,(H,33,35)(H,31,34,36) GWGDDCZPUYQMOV-UHFFFAOYSA-N 745841 US12319655, Example 323 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745841 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745841&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930549 518818577 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533235 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4cnn(C5CC5)c4)cnc3C)c2)ccn1 InChI=1S/C24H22N8O2/c1-14-20(9-18(12-27-14)30-23(33)17-11-29-32(13-17)19-3-4-19)21-8-16(10-28-31-21)15-5-6-26-22(7-15)24(34)25-2/h5-13,19H,3-4H2,1-2H3,(H,25,34)(H,30,33) UDISWTOPFSOIGH-UHFFFAOYSA-N 745842 US12319655, Example 324 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745842 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745842&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169944252 518818578 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533239 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)c2)ccn1 InChI=1S/C27H25FN6O2/c1-16-5-6-20(33-25(35)18-8-10-31-24(13-18)27(2,3)28)14-21(16)22-12-19(15-32-34-22)17-7-9-30-23(11-17)26(36)29-4/h5-15H,1-4H3,(H,29,36)(H,33,35) QPFNLEROTJJTJV-UHFFFAOYSA-N 745843 US12319655, Example 325 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745843 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745843&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170100818 518818579 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533243 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C5CC5)c4)ccc3C)c2)ccn1 InChI=1S/C27H24N6O2/c1-16-3-6-21(32-26(34)19-8-10-29-23(12-19)17-4-5-17)14-22(16)24-13-20(15-31-33-24)18-7-9-30-25(11-18)27(35)28-2/h3,6-15,17H,4-5H2,1-2H3,(H,28,35)(H,32,34) HWVSHQRRXJNQEA-UHFFFAOYSA-N 745844 US12319655, Example 326 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745844 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745844&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170100817 518818580 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533247 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(F)F)c4)ccc3C)c2)ccn1 InChI=1S/C25H20F2N6O2/c1-14-3-4-18(32-24(34)16-6-8-29-21(10-16)23(26)27)12-19(14)20-11-17(13-31-33-20)15-5-7-30-22(9-15)25(35)28-2/h3-13,23H,1-2H3,(H,28,35)(H,32,34) UGGICEKYIPTZMF-UHFFFAOYSA-N 745845 US12319655, Example 327 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745845 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745845&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170100816 518818581 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533251 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(C)(C)OC)c4)ccc3C)c2)ccn1 InChI=1S/C28H28N6O3/c1-17-6-7-21(33-26(35)19-9-11-31-25(14-19)28(2,3)37-5)15-22(17)23-13-20(16-32-34-23)18-8-10-30-24(12-18)27(36)29-4/h6-16H,1-5H3,(H,29,36)(H,33,35) MDXWAONEQZFPBD-UHFFFAOYSA-N 745846 US12319655, Example 328 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745846 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745846&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170100815 518818582 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533255 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccc(F)c(C(F)(F)F)c4)ccc3C)c2)ccn1 InChI=1S/C26H19F4N5O2/c1-14-3-5-18(34-24(36)16-4-6-21(27)20(9-16)26(28,29)30)12-19(14)22-11-17(13-33-35-22)15-7-8-32-23(10-15)25(37)31-2/h3-13H,1-2H3,(H,31,37)(H,34,36) XWOKWZDBJUMYEQ-UHFFFAOYSA-N 745847 US12319655, Example 329 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745847 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745847&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170100797 518818583 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533259 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(F)F)c4)cnc3C)c2)ccn1 InChI=1S/C24H19F2N7O2/c1-13-18(10-17(12-30-13)32-23(34)15-4-6-28-20(8-15)22(25)26)19-9-16(11-31-33-19)14-3-5-29-21(7-14)24(35)27-2/h3-12,22H,1-2H3,(H,27,35)(H,32,34) VVMSQBLVEXEYHN-UHFFFAOYSA-N 745848 US12319655, Example 330 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745848 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745848&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170100795 518818584 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533263 Cc1ccc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C29H26N6O2/c1-17-2-7-23(33-29(37)21-9-10-30-25(12-21)18-3-4-18)15-24(17)26-13-22(16-32-35-26)20-8-11-31-27(14-20)34-28(36)19-5-6-19/h2,7-16,18-19H,3-6H2,1H3,(H,33,37)(H,31,34,36) MYAZBAYLQQVACG-UHFFFAOYSA-N 745849 US12319655, Example 331 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745849 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745849&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929889 518818585 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533267 Cc1ccc(NC(=O)c2ccnc(S(C)(=O)=O)c2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C27H24N6O4S/c1-16-3-6-21(31-27(35)19-8-10-29-25(13-19)38(2,36)37)14-22(16)23-11-20(15-30-33-23)18-7-9-28-24(12-18)32-26(34)17-4-5-17/h3,6-15,17H,4-5H2,1-2H3,(H,31,35)(H,28,32,34) FCGGMMIRDYVIAK-UHFFFAOYSA-N 745850 US12319655, Example 332 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745850 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745850&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024686 518818586 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533271 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)CCC(C)(C)C#N)cnc3C)c2)ccn1 InChI=1S/C24H25N7O2/c1-15-19(11-18(13-28-15)30-22(32)5-7-24(2,3)14-25)20-10-17(12-29-31-20)16-6-8-27-21(9-16)23(33)26-4/h6,8-13H,5,7H2,1-4H3,(H,26,33)(H,30,32) SHLYKDHZJHOYLE-UHFFFAOYSA-N 745851 US12319655, Example 333 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745851 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745851&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929649 518818587 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533275 Cc1ncc(NC(=O)C2CCN(C)C2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C25H27N7O2/c1-15-20(12-19(13-28-15)29-25(34)18-7-10-32(2)14-18)23-27-9-6-21(30-23)17-5-8-26-22(11-17)31-24(33)16-3-4-16/h5-6,8-9,11-13,16,18H,3-4,7,10,14H2,1-2H3,(H,29,34)(H,26,31,33) YLEXUIARNOZGEA-UHFFFAOYSA-N 745852 US12319655, Example 334 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745852 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745852&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930253 518818588 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533279 Cc1ncc(NC(=O)C2CCOC2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C24H24N6O3/c1-14-19(11-18(12-27-14)28-24(32)17-6-9-33-13-17)22-26-8-5-20(29-22)16-4-7-25-21(10-16)30-23(31)15-2-3-15/h4-5,7-8,10-12,15,17H,2-3,6,9,13H2,1H3,(H,28,32)(H,25,30,31) CGLHLGNNDDTEJQ-UHFFFAOYSA-N 745853 US12319655, Example 335 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745853 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745853&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929480 518818589 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533283 Cc1ncc(NC(=O)C2CCOCC2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C25H26N6O3/c1-15-20(13-19(14-28-15)29-24(32)17-6-10-34-11-7-17)21-5-9-27-23(30-21)18-4-8-26-22(12-18)31-25(33)16-2-3-16/h4-5,8-9,12-14,16-17H,2-3,6-7,10-11H2,1H3,(H,29,32)(H,26,31,33) WEMBWEBKGIKOJS-UHFFFAOYSA-N 745854 US12319655, Example 336 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745854 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745854&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929241 518818590 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533287 Cc1ncc(NC(=O)C2CCOC2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C24H24N6O3/c1-14-19(11-18(12-27-14)28-24(32)17-6-9-33-13-17)20-5-8-26-22(29-20)16-4-7-25-21(10-16)30-23(31)15-2-3-15/h4-5,7-8,10-12,15,17H,2-3,6,9,13H2,1H3,(H,28,32)(H,25,30,31) WVYWHAATELJVTN-UHFFFAOYSA-N 745855 US12319655, Example 337 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745855 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745855&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930448 518818591 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533291 Cc1ncc(NC(=O)C2CCC3(CC2)COC3)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C28H30N6O3/c1-17-22(13-21(14-31-17)32-26(35)19-4-8-28(9-5-19)15-37-16-28)25-30-11-7-23(33-25)20-6-10-29-24(12-20)34-27(36)18-2-3-18/h6-7,10-14,18-19H,2-5,8-9,15-16H2,1H3,(H,32,35)(H,29,34,36) PORWVLBOHJREKK-UHFFFAOYSA-N 745856 US12319655, Example 338 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745856&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929260 518818592 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533295 Cc1ncc(NC(=O)C2CCOCC2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C25H26N6O3/c1-15-20(13-19(14-28-15)29-24(32)17-6-10-34-11-7-17)23-27-9-5-21(30-23)18-4-8-26-22(12-18)31-25(33)16-2-3-16/h4-5,8-9,12-14,16-17H,2-3,6-7,10-11H2,1H3,(H,29,32)(H,26,31,33) BWSIGGVORCOYBB-UHFFFAOYSA-N 745857 US12319655, Example 339 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745857 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745857&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929892 518818593 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533299 Cc1ccc(NC(=O)C23CCC(C#N)(CC2)CC3)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H30N6O2/c1-19-2-5-22(34-28(38)30-11-8-29(18-31,9-12-30)10-13-30)17-23(19)24-7-15-33-26(35-24)21-6-14-32-25(16-21)36-27(37)20-3-4-20/h2,5-7,14-17,20H,3-4,8-13H2,1H3,(H,34,38)(H,32,36,37) RVYPVOUVOSFVPM-UHFFFAOYSA-N 745858 US12319655, Example 340 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745858 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745858&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930071 518818594 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533303 CO[C@H]1CC[C@H](C(=O)Nc2ccc(C)c(-c3ccnc(-c4ccnc(NC(=O)C5CC5)c4)n3)c2)CC1 InChI=1S/C28H31N5O3/c1-17-3-8-21(31-27(34)19-6-9-22(36-2)10-7-19)16-23(17)24-12-14-30-26(32-24)20-11-13-29-25(15-20)33-28(35)18-4-5-18/h3,8,11-16,18-19,22H,4-7,9-10H2,1-2H3,(H,31,34)(H,29,33,35) HZPUUWQWICBTCZ-UHFFFAOYSA-N 745859 US12319655, Example 341 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745859&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024601 518818595 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533307 Cc1ncc(NC(=O)C23CCC(C#N)(CC2)CC3)cc1-c1cccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C30H30N6O2/c1-19-23(16-22(17-33-19)34-28(38)30-11-8-29(18-31,9-12-30)10-13-30)25-4-2-3-24(35-25)21-7-14-32-26(15-21)36-27(37)20-5-6-20/h2-4,7,14-17,20H,5-6,8-13H2,1H3,(H,34,38)(H,32,36,37) WXLMCHCASJAPMB-UHFFFAOYSA-N 745860 US12319655, Example 342 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745860 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745860&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930596 518818596 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533311 CO[C@H]1CC[C@H](C(=O)Nc2cnc(C)c(-c3cccc(-c4ccnc(NC(=O)C5CC5)c4)n3)c2)CC1 InChI=1S/C28H31N5O3/c1-17-23(15-21(16-30-17)31-27(34)19-8-10-22(36-2)11-9-19)25-5-3-4-24(32-25)20-12-13-29-26(14-20)33-28(35)18-6-7-18/h3-5,12-16,18-19,22H,6-11H2,1-2H3,(H,31,34)(H,29,33,35) GLFOOLOHDRRDOA-UHFFFAOYSA-N 745861 US12319655, Example 343 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745861 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745861&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024687 518818597 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533315 Cc1ccc(NC(=O)C2CCN(C)C2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C27H29N5O2/c1-17-6-9-22(30-27(34)21-10-11-32(2)15-21)13-23(17)19-4-3-5-20(12-19)24-14-25(29-16-28-24)31-26(33)18-7-8-18/h3-6,9,12-14,16,18,21H,7-8,10-11,15H2,1-2H3,(H,30,34)(H,28,29,31,33) APOSBLYUJLFUHG-UHFFFAOYSA-N 745862 US12319655, Example 344 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745862 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745862&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930429 518818598 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533319 Cc1ccc(NC(=O)C2CCOC2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C26H26N4O3/c1-16-5-8-21(29-26(32)20-9-10-33-14-20)12-22(16)18-3-2-4-19(11-18)23-13-24(28-15-27-23)30-25(31)17-6-7-17/h2-5,8,11-13,15,17,20H,6-7,9-10,14H2,1H3,(H,29,32)(H,27,28,30,31) YLLXVXHSMPYMFE-UHFFFAOYSA-N 745863 US12319655, Example 345 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745863 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745863&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929580 518818599 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533323 Cc1ccc(NC(=O)C2CN(C)CCO2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C27H29N5O3/c1-17-6-9-21(30-27(34)24-15-32(2)10-11-35-24)13-22(17)19-4-3-5-20(12-19)23-14-25(29-16-28-23)31-26(33)18-7-8-18/h3-6,9,12-14,16,18,24H,7-8,10-11,15H2,1-2H3,(H,30,34)(H,28,29,31,33) DXBIPTFFOQMDSZ-UHFFFAOYSA-N 745864 US12319655, Example 346 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745864 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745864&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930250 518818600 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533327 CO[C@H]1CC[C@H](C(=O)Nc2cnc(C)c(-c3cccc(-c4cc(NC(=O)C5CC5)ncn4)c3)c2)CC1 InChI=1S/C28H31N5O3/c1-17-24(13-22(15-29-17)32-27(34)19-8-10-23(36-2)11-9-19)20-4-3-5-21(12-20)25-14-26(31-16-30-25)33-28(35)18-6-7-18/h3-5,12-16,18-19,23H,6-11H2,1-2H3,(H,32,34)(H,30,31,33,35) VQXPCYFIWOCGPE-UHFFFAOYSA-N 745865 US12319655, Example 347 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745865 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745865&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024709 518818601 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533331 Cc1ncc(NC(=O)C2CCOC(C)(C)C2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C28H31N5O3/c1-17-23(12-22(15-29-17)32-27(35)21-9-10-36-28(2,3)14-21)19-5-4-6-20(11-19)24-13-25(31-16-30-24)33-26(34)18-7-8-18/h4-6,11-13,15-16,18,21H,7-10,14H2,1-3H3,(H,32,35)(H,30,31,33,34) LYLDZRVHSHLMEN-UHFFFAOYSA-N 745866 US12319655, Example 348 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745866 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745866&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929770 518818602 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533335 Cc1ncc(NC(=O)C2CCOCC2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C26H27N5O3/c1-16-22(12-21(14-27-16)30-25(32)18-7-9-34-10-8-18)19-3-2-4-20(11-19)23-13-24(29-15-28-23)31-26(33)17-5-6-17/h2-4,11-15,17-18H,5-10H2,1H3,(H,30,32)(H,28,29,31,33) MFDMHWVANDUTKZ-UHFFFAOYSA-N 745867 US12319655, Example 349 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745867 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745867&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929288 518818603 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533339 Cc1ncc(NC(=O)C2CNCCO2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C25H26N6O3/c1-15-20(10-19(12-27-15)30-25(33)22-13-26-7-8-34-22)17-3-2-4-18(9-17)21-11-23(29-14-28-21)31-24(32)16-5-6-16/h2-4,9-12,14,16,22,26H,5-8,13H2,1H3,(H,30,33)(H,28,29,31,32) PTMJDJIMFHIURS-UHFFFAOYSA-N 745868 US12319655, Example 350 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745868 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745868&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930300 518818604 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533343 Cc1ncc(NC(=O)C2CCN(C)C2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C26H28N6O2/c1-16-22(11-21(13-27-16)30-26(34)20-8-9-32(2)14-20)18-4-3-5-19(10-18)23-12-24(29-15-28-23)31-25(33)17-6-7-17/h3-5,10-13,15,17,20H,6-9,14H2,1-2H3,(H,30,34)(H,28,29,31,33) FNSPONYJHBWZMC-UHFFFAOYSA-N 745869 US12319655, Example 351 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745869 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745869&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930585 518818605 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533347 Cc1ncc(NC(=O)C2CCOC2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C25H25N5O3/c1-15-21(10-20(12-26-15)29-25(32)19-7-8-33-13-19)17-3-2-4-18(9-17)22-11-23(28-14-27-22)30-24(31)16-5-6-16/h2-4,9-12,14,16,19H,5-8,13H2,1H3,(H,29,32)(H,27,28,30,31) TYNSEVIUQDYEJJ-UHFFFAOYSA-N 745870 US12319655, Example 352 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745870 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745870&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930394 518818606 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533351 Cc1ncc(NC(=O)CN2CCOCC2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C26H28N6O3/c1-17-22(12-21(14-27-17)30-25(33)15-32-7-9-35-10-8-32)19-3-2-4-20(11-19)23-13-24(29-16-28-23)31-26(34)18-5-6-18/h2-4,11-14,16,18H,5-10,15H2,1H3,(H,30,33)(H,28,29,31,34) SUXFRLCJGKQWQB-UHFFFAOYSA-N 745871 US12319655, Example 353 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745871 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745871&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930278 518818607 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533355 Cc1ncc(NC(=O)CC2CC(F)(F)C2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C25H24F2N6O2/c1-14-19(10-18(13-30-14)31-22(34)8-15-11-25(26,27)12-15)23-29-7-5-20(32-23)17-4-6-28-21(9-17)33-24(35)16-2-3-16/h4-7,9-10,13,15-16H,2-3,8,11-12H2,1H3,(H,31,34)(H,28,33,35) LSBLOKDGZUKADU-UHFFFAOYSA-N 745872 US12319655, Example 354 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745872&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929711 518818608 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533359 Cc1ncc(NC(=O)CC2COC2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C24H24N6O3/c1-14-19(10-18(11-27-14)28-22(31)8-15-12-33-13-15)23-26-7-5-20(29-23)17-4-6-25-21(9-17)30-24(32)16-2-3-16/h4-7,9-11,15-16H,2-3,8,12-13H2,1H3,(H,28,31)(H,25,30,32) HFWVUQBQNORZDX-UHFFFAOYSA-N 745873 US12319655, Example 355 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745873 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745873&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930245 518818609 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533363 Cc1ncc(NC(=O)CC2COC2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C25H25N5O3/c1-15-21(9-20(11-26-15)29-24(31)7-16-12-33-13-16)18-3-2-4-19(8-18)22-10-23(28-14-27-22)30-25(32)17-5-6-17/h2-4,8-11,14,16-17H,5-7,12-13H2,1H3,(H,29,31)(H,27,28,30,32) FCFQUFJLJXCNRG-UHFFFAOYSA-N 745874 US12319655, Example 356 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745874 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745874&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929542 518818610 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533367 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)CCC(C)(C)C#N)ccc3C)ccn2)ccn1 InChI=1S/C26H27N5O2/c1-17-5-6-20(31-24(32)7-10-26(2,3)16-27)15-21(17)18-8-11-29-22(13-18)19-9-12-30-23(14-19)25(33)28-4/h5-6,8-9,11-15H,7,10H2,1-4H3,(H,28,33)(H,31,32) URHWLFFRUJXBSN-UHFFFAOYSA-N 745875 US12319655, Example 357 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745875 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745875&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930399 518818611 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533371 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)COCC4CC4)ccc3C)ccn2)ccn1 InChI=1S/C25H26N4O3/c1-16-3-6-20(29-24(30)15-32-14-17-4-5-17)13-21(16)18-7-9-27-22(11-18)19-8-10-28-23(12-19)25(31)26-2/h3,6-13,17H,4-5,14-15H2,1-2H3,(H,26,31)(H,29,30) YUAVESSEKWZUID-UHFFFAOYSA-N 745876 US12319655, Example 358 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745876 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745876&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930344 518818612 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533375 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)CN4CCCC4)cnc3C)c2)ccn1 InChI=1S/C23H25N7O3/c1-15-19(11-18(13-25-15)27-22(31)14-30-7-3-4-8-30)20-9-17(12-26-29-20)16-5-6-24-21(10-16)28-23(32)33-2/h5-6,9-13H,3-4,7-8,14H2,1-2H3,(H,27,31)(H,24,28,32) RVMXGJCHCKRWLD-UHFFFAOYSA-N 745877 US12319655, Example 359 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745877 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745877&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930119 518818613 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533379 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)COCC4CC4)ccc3C)c2)ccn1 InChI=1S/C24H25N5O4/c1-15-3-6-19(27-23(30)14-33-13-16-4-5-16)11-20(15)21-9-18(12-26-29-21)17-7-8-25-22(10-17)28-24(31)32-2/h3,6-12,16H,4-5,13-14H2,1-2H3,(H,27,30)(H,25,28,31) WYTAVPRWYREUIB-UHFFFAOYSA-N 745878 US12319655, Example 360 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745878&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024710 518818614 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533383 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)cnc3C)c2)ccn1 InChI=1S/C26H24FN7O3/c1-15-20(12-19(14-30-15)32-24(35)17-6-7-28-22(10-17)26(2,3)27)21-9-18(13-31-34-21)16-5-8-29-23(11-16)33-25(36)37-4/h5-14H,1-4H3,(H,32,35)(H,29,33,36) ZWQHQAGTCYTFHB-UHFFFAOYSA-N 745879 US12319655, Example 361 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745879&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929923 518818615 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533387 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C5CC5)c4)cnc3C)c2)ccn1 InChI=1S/C26H23N7O3/c1-15-21(12-20(14-29-15)31-25(34)18-6-7-27-22(9-18)16-3-4-16)23-10-19(13-30-33-23)17-5-8-28-24(11-17)32-26(35)36-2/h5-14,16H,3-4H2,1-2H3,(H,31,34)(H,28,32,35) XRQMKNWIGMAOPB-UHFFFAOYSA-N 745880 US12319655, Example 362 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745880&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929976 518818616 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533391 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(F)F)c4)cnc3C)c2)ccn1 InChI=1S/C24H19F2N7O3/c1-13-18(10-17(12-29-13)31-23(34)15-4-5-27-20(7-15)22(25)26)19-8-16(11-30-33-19)14-3-6-28-21(9-14)32-24(35)36-2/h3-12,22H,1-2H3,(H,31,34)(H,28,32,35) LNNIAIRSISBZJJ-UHFFFAOYSA-N 745881 US12319655, Example 363 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745881 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745881&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930109 518818617 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533395 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3C)c2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-3-4-18(33-23(35)16-6-8-31-22(11-16)25(26,27)28)12-19(14)20-10-17(13-32-34-20)15-5-7-30-21(9-15)24(36)29-2/h3-13H,1-2H3,(H,29,36)(H,33,35) CXAUSJVHFXPKAJ-UHFFFAOYSA-N 745882 US12319655, Example 364 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745882 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745882&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930642 518818618 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533399 COCCNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4cccc(C5CC5)c4)ccc3C)c2)ccn1 InChI=1S/C30H29N5O3/c1-19-6-9-25(34-29(36)23-5-3-4-21(14-23)20-7-8-20)17-26(19)27-16-24(18-33-35-27)22-10-11-31-28(15-22)30(37)32-12-13-38-2/h3-6,9-11,14-18,20H,7-8,12-13H2,1-2H3,(H,32,37)(H,34,36) CLSPQXSLMGYRIV-UHFFFAOYSA-N 745883 US12319655, Example 365 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745883 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745883&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169931981 518818619 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533403 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)c4cn(C(C)(C)C)nn4)ccc3C)c2)ccn1 InChI=1S/C25H26N8O2/c1-15-6-7-18(29-24(35)22-14-33(32-31-22)25(2,3)4)12-19(15)20-11-17(13-28-30-20)16-8-9-27-21(10-16)23(34)26-5/h6-14H,1-5H3,(H,26,34)(H,29,35) ZEDWIXQPQPZCEX-UHFFFAOYSA-N 745884 US12319655, Example 366 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745884 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745884&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170100668 518818620 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533407 Cc1ccc(NC(=O)c2cc(C(C)(C)C)no2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C28H28N6O3/c1-16-5-8-20(31-27(36)23-14-24(34-37-23)28(2,3)4)13-21(16)22-11-19(15-30-33-22)18-9-10-29-25(12-18)32-26(35)17-6-7-17/h5,8-15,17H,6-7H2,1-4H3,(H,31,36)(H,29,32,35) VKUWFZKGXAWJBB-UHFFFAOYSA-N 745885 US12319655, Example 367 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745885 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745885&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024616 518818621 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533411 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)CC4CCCC4)cnc3C)c2)ccn1 InChI=1S/C24H26N6O3/c1-15-20(12-19(14-26-15)28-23(31)9-16-5-3-4-6-16)21-10-18(13-27-30-21)17-7-8-25-22(11-17)29-24(32)33-2/h7-8,10-14,16H,3-6,9H2,1-2H3,(H,28,31)(H,25,29,32) KACHAGPQGKACBC-UHFFFAOYSA-N 745886 US12319655, Example 368 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745886 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745886&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929295 518818622 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533415 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(-c2ccnc3[nH]ccc23)cnn1 InChI=1S/C28H23N7O/c1-17-4-5-20(34-27(36)18-6-9-30-25(13-18)28(2,3)16-29)14-23(17)24-12-19(15-33-35-24)21-7-10-31-26-22(21)8-11-32-26/h4-15H,1-3H3,(H,31,32)(H,34,36) FJLMAYALCPXYBJ-UHFFFAOYSA-N 745887 US12319655, Example 369 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745887&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024681 518818623 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533419 Cc1ccc(NC(=O)C2CCOC(C(C)C)C2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C29H33N5O3/c1-17(2)26-13-21(9-11-37-26)29(36)32-23-7-4-18(3)24(15-23)25-12-22(16-31-34-25)20-8-10-30-27(14-20)33-28(35)19-5-6-19/h4,7-8,10,12,14-17,19,21,26H,5-6,9,11,13H2,1-3H3,(H,32,36)(H,30,33,35) URLFTPBJDSDUGW-UHFFFAOYSA-N 745888 US12319655, Example 370 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745888&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929722 518818624 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533423 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)cnc2C)ccn1 InChI=1S/C29H28FN5O2/c1-17-6-7-22(35-27(36)20-9-11-33-26(14-20)29(3,4)30)15-23(17)21-12-24(18(2)34-16-21)19-8-10-32-25(13-19)28(37)31-5/h6-16H,1-5H3,(H,31,37)(H,35,36) OBHVCBAWCBREAT-UHFFFAOYSA-N 745889 US12319655, Example 371 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745889&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929661 518818625 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533427 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(-c2ccnc(C(=O)NC3CC3)c2)cnn1 InChI=1S/C30H27N7O2/c1-18-4-5-23(36-28(38)20-9-11-33-27(14-20)30(2,3)17-31)15-24(18)25-13-21(16-34-37-25)19-8-10-32-26(12-19)29(39)35-22-6-7-22/h4-5,8-16,22H,6-7H2,1-3H3,(H,35,39)(H,36,38) IVTWVXUXIZVYPO-UHFFFAOYSA-N 745890 US12319655, Example 372 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745890 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745890&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 170104443 518818626 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533431 Cc1ccc(NC(=O)c2cn(C(C)C)nc2C)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C28H29N7O2/c1-16(2)35-15-24(18(4)34-35)28(37)31-22-8-5-17(3)23(13-22)25-11-21(14-30-33-25)20-9-10-29-26(12-20)32-27(36)19-6-7-19/h5,8-16,19H,6-7H2,1-4H3,(H,31,37)(H,29,32,36) LLUARVNAPKNKMZ-UHFFFAOYSA-N 745891 US12319655, Example 373 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745891 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745891&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930290 518818627 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533435 CNC(=O)c1cc(-c2cnnc(-c3cc(NC(=O)CCC4(F)CC4)cnc3C)c2)ccn1 InChI=1S/C23H23FN6O2/c1-14-18(11-17(13-27-14)29-21(31)3-5-23(24)6-7-23)19-10-16(12-28-30-19)15-4-8-26-20(9-15)22(32)25-2/h4,8-13H,3,5-7H2,1-2H3,(H,25,32)(H,29,31) NTQIYUGBQSARFY-UHFFFAOYSA-N 745892 US12319655, Example 374 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745892 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745892&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930391 518818628 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533439 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)c2)ccn1 InChI=1S/C27H25FN6O3/c1-16-5-6-20(32-25(35)18-8-9-29-23(12-18)27(2,3)28)14-21(16)22-11-19(15-31-34-22)17-7-10-30-24(13-17)33-26(36)37-4/h5-15H,1-4H3,(H,32,35)(H,30,33,36) ADPMQNMPOHJXMC-UHFFFAOYSA-N 745893 US12319655, Example 375 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745893 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745893&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930688 518818629 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533443 CNC(=O)c1cc(-c2ccnc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)c2)ccn1 InChI=1S/C29H26N6O2/c1-18-5-6-22(35-27(36)21-9-12-34-26(15-21)29(2,3)17-30)16-23(18)24-13-19(7-10-32-24)20-8-11-33-25(14-20)28(37)31-4/h5-16H,1-4H3,(H,31,37)(H,35,36) AVIKBGCIDWSKSQ-UHFFFAOYSA-N 745894 US12319655, Example 376 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745894 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745894&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929884 518818630 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533447 Cc1ccc(NC(=O)c2cc(C3CC3)n(C)n2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C28H27N7O2/c1-16-3-8-21(31-28(37)24-14-25(17-4-5-17)35(2)34-24)13-22(16)23-11-20(15-30-33-23)19-9-10-29-26(12-19)32-27(36)18-6-7-18/h3,8-15,17-18H,4-7H2,1-2H3,(H,31,37)(H,29,32,36) BZFWOCYMPTUFKY-UHFFFAOYSA-N 745895 US12319655, Example 377 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745895 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745895&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024658 518818631 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533451 CNC(=O)c1cc(-c2ccnc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)c2)ccn1 InChI=1S/C28H26FN5O2/c1-17-5-6-21(34-26(35)20-9-12-33-25(15-20)28(2,3)29)16-22(17)23-13-18(7-10-31-23)19-8-11-32-24(14-19)27(36)30-4/h5-16H,1-4H3,(H,30,36)(H,34,35) CIINVASEHKOEKV-UHFFFAOYSA-N 745896 US12319655, Example 378 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745896 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745896&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929323 518818632 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533455 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)c2)ncn1 InChI=1S/C27H25FN6O2/c1-16-5-6-20(34-25(35)17-7-8-31-24(10-17)27(2,3)28)11-21(16)18-9-19(14-30-13-18)22-12-23(26(36)29-4)33-15-32-22/h5-15H,1-4H3,(H,29,36)(H,34,35) MTIXQMBTLNTWFY-UHFFFAOYSA-N 745897 US12319655, Example 379 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745897 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745897&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929332 518818633 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533459 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cncc(-c2ccnc(C(N)=O)c2)c1 InChI=1S/C27H24FN5O2/c1-16-4-5-21(33-26(35)18-7-9-32-24(12-18)27(2,3)28)13-22(16)20-10-19(14-30-15-20)17-6-8-31-23(11-17)25(29)34/h4-15H,1-3H3,(H2,29,34)(H,33,35) GCTAVVANFKUORU-UHFFFAOYSA-N 745898 US12319655, Example 380 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745898 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745898&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930206 518818634 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533463 Cc1ccc(NC(=O)c2cnn(CC(F)(F)F)c2)cc1-c1cncc(-c2ccnc(C(N)=O)c2)c1 InChI=1S/C24H19F3N6O2/c1-14-2-3-19(32-23(35)18-11-31-33(12-18)13-24(25,26)27)8-20(14)17-6-16(9-29-10-17)15-4-5-30-21(7-15)22(28)34/h2-12H,13H2,1H3,(H2,28,34)(H,32,35) FKHDIOIOSAOBRX-UHFFFAOYSA-N 745899 US12319655, Example 381 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745899 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745899&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024683 518818635 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533467 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4cnn(CC(F)(F)F)c4)ccc3C)c2)ncn1 InChI=1S/C24H20F3N7O2/c1-14-3-4-18(33-22(35)17-10-32-34(11-17)12-24(25,26)27)6-19(14)15-5-16(9-29-8-15)20-7-21(23(36)28-2)31-13-30-20/h3-11,13H,12H2,1-2H3,(H,28,36)(H,33,35) LDKKDDGMAPYLOJ-UHFFFAOYSA-N 745900 US12319655, Example 382 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745900 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745900&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930507 518818636 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533471 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)Cn4cc(C(C)C)nn4)ccc3C)c2)ncn1 InChI=1S/C25H26N8O2/c1-15(2)23-12-33(32-31-23)13-24(34)30-19-6-5-16(3)20(8-19)17-7-18(11-27-10-17)21-9-22(25(35)26-4)29-14-28-21/h5-12,14-15H,13H2,1-4H3,(H,26,35)(H,30,34) ZGUJYPFFUVJSHJ-UHFFFAOYSA-N 745901 US12319655, Example 383 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745901 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745901&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929458 518818637 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533475 COC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)c(F)cc3C)c2)ccn1 InChI=1S/C28H25F2N5O3/c1-16-9-22(29)23(34-26(36)18-6-7-32-24(11-18)28(2,3)30)13-21(16)20-10-19(14-31-15-20)17-5-8-33-25(12-17)35-27(37)38-4/h5-15H,1-4H3,(H,34,36)(H,33,35,37) CDBLGRBEAWRXIA-UHFFFAOYSA-N 745902 US12319655, Example 384 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745902&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930315 518818638 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533479 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2ncnn3cccc23)c1 InChI=1S/C28H23N7O/c1-18-23(19-6-4-7-20(12-19)26-24-8-5-11-35(24)33-17-32-26)14-22(15-31-18)34-27(36)21-9-10-30-25(13-21)28(2,3)16-29/h4-15,17H,1-3H3,(H,34,36) LZZXTJYSJVICHQ-UHFFFAOYSA-N 745903 US12319655, Example 385 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745903 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745903&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929475 518818639 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533483 COC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)c(F)cc3C)cc(C)n2)ccn1 InChI=1S/C29H27F2N5O3/c1-16-10-22(30)24(35-27(37)19-7-8-32-25(13-19)29(3,4)31)15-21(16)20-11-17(2)34-23(12-20)18-6-9-33-26(14-18)36-28(38)39-5/h6-15H,1-5H3,(H,35,37)(H,33,36,38) ZRQYTUOFEXRFAV-UHFFFAOYSA-N 745904 US12319655, Example 386 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745904 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745904&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929246 518818640 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533487 Cc1ccc(NC(=O)c2cc(C(F)(F)F)c(=O)n(C)c2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C28H23F3N6O3/c1-15-3-6-20(34-26(39)19-9-22(28(29,30)31)27(40)37(2)14-19)12-21(15)23-10-18(13-33-36-23)17-7-8-32-24(11-17)35-25(38)16-4-5-16/h3,6-14,16H,4-5H2,1-2H3,(H,34,39)(H,32,35,38) YOXUHECQAKIIKQ-UHFFFAOYSA-N 745905 US12319655, Example 387 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745905 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745905&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024629 518818641 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533491 Cc1ccc(NC(=O)[C@H]2CCO[C@@H](C(C)C)C2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C29H33N5O3/c1-17(2)26-13-21(9-11-37-26)29(36)32-23-7-4-18(3)24(15-23)25-12-22(16-31-34-25)20-8-10-30-27(14-20)33-28(35)19-5-6-19/h4,7-8,10,12,14-17,19,21,26H,5-6,9,11,13H2,1-3H3,(H,32,36)(H,30,33,35) URLFTPBJDSDUGW-UHFFFAOYSA-N 745906 US12319655, Example 388 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745906 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745906&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930638 518818642 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533495 Cc1ccc(NC(=O)[C@H]2CCO[C@H](C(C)C)C2)cc1-c1cc(-c2ccnc(NC(=O)C3CC3)c2)cnn1 InChI=1S/C29H33N5O3/c1-17(2)26-13-21(9-11-37-26)29(36)32-23-7-4-18(3)24(15-23)25-12-22(16-31-34-25)20-8-10-30-27(14-20)33-28(35)19-5-6-19/h4,7-8,10,12,14-17,19,21,26H,5-6,9,11,13H2,1-3H3,(H,32,36)(H,30,33,35) URLFTPBJDSDUGW-UHFFFAOYSA-N 745907 US12319655, Example 389 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745907 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745907&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024532 518818643 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533499 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3F)c2)ccn1 InChI=1S/C27H22FN7O3/c1-27(2,15-29)23-11-17(7-8-30-23)25(36)33-19-4-5-21(28)20(13-19)22-10-18(14-32-35-22)16-6-9-31-24(12-16)34-26(37)38-3/h4-14H,1-3H3,(H,33,36)(H,31,34,37) JBDUFEWXTPYVLY-UHFFFAOYSA-N 745908 US12319655, Example 390 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745908&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929847 518818644 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533503 COC(=O)Nc1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)n2)ccn1 InChI=1S/C27H25FN6O3/c1-16-5-6-19(32-25(35)18-8-10-29-22(13-18)27(2,3)28)15-20(16)21-9-12-31-24(33-21)17-7-11-30-23(14-17)34-26(36)37-4/h5-15H,1-4H3,(H,32,35)(H,30,34,36) QKWODMZHMZAZIR-UHFFFAOYSA-N 745909 US12319655, Example 391 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745909&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930716 518818645 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533507 CNC(=O)c1cc(-c2ccnc(-c3cc(NC(=O)CCC4(F)CC4)ccc3C)c2)ccn1 InChI=1S/C25H25FN4O2/c1-16-3-4-19(30-23(31)5-8-25(26)9-10-25)15-20(16)21-13-17(6-11-28-21)18-7-12-29-22(14-18)24(32)27-2/h3-4,6-7,11-15H,5,8-10H2,1-2H3,(H,27,32)(H,30,31) BDCNBGBTOXLVCJ-UHFFFAOYSA-N 745910 US12319655, Example 392 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745910 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745910&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930352 518818646 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533511 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C5(C#N)CC5)c4)ccc3C)c2)ncn1 InChI=1S/C28H23N7O2/c1-17-3-4-21(35-26(36)18-5-8-32-25(10-18)28(15-29)6-7-28)11-22(17)19-9-20(14-31-13-19)23-12-24(27(37)30-2)34-16-33-23/h3-5,8-14,16H,6-7H2,1-2H3,(H,30,37)(H,35,36) KGZNYLMTUNTLEN-UHFFFAOYSA-N 745911 US12319655, Example 393 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745911&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929894 518818647 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533515 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C29H27FN6O2/c1-17-4-7-22(35-28(38)19-8-9-32-25(11-19)29(2,3)30)12-23(17)20-10-21(15-31-14-20)24-13-26(34-16-33-24)36-27(37)18-5-6-18/h4,7-16,18H,5-6H2,1-3H3,(H,35,38)(H,33,34,36,37) DGZLEKAUSREXIW-UHFFFAOYSA-N 745912 US12319655, Example 394 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745912&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929550 518818648 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533519 Cc1ccc(NC(=O)c2ccnc(C3(C#N)CC3)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C30H25N7O2/c1-18-2-5-23(36-29(39)20-6-9-33-26(11-20)30(16-31)7-8-30)12-24(18)21-10-22(15-32-14-21)25-13-27(35-17-34-25)37-28(38)19-3-4-19/h2,5-6,9-15,17,19H,3-4,7-8H2,1H3,(H,36,39)(H,34,35,37,38) HAJUWMSMISQMCE-UHFFFAOYSA-N 745913 US12319655, Example 395 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745913 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745913&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929785 518818649 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533523 Cc1ccc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C29H26N6O2/c1-17-2-7-23(34-29(37)20-8-9-31-25(11-20)18-3-4-18)12-24(17)21-10-22(15-30-14-21)26-13-27(33-16-32-26)35-28(36)19-5-6-19/h2,7-16,18-19H,3-6H2,1H3,(H,34,37)(H,32,33,35,36) ROAYLPONCZEMMD-UHFFFAOYSA-N 745914 US12319655, Example 396 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745914 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745914&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929615 518818650 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533527 Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C27H21F3N6O2/c1-15-2-5-20(35-26(38)17-6-7-32-23(9-17)27(28,29)30)10-21(15)18-8-19(13-31-12-18)22-11-24(34-14-33-22)36-25(37)16-3-4-16/h2,5-14,16H,3-4H2,1H3,(H,35,38)(H,33,34,36,37) DAOIZPZGXMKLAN-UHFFFAOYSA-N 745915 US12319655, Example 397 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745915 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745915&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930677 518818651 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533531 Cc1cc(F)c(NC(=O)c2ccnc(C3CC3)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C29H25FN6O2/c1-16-8-23(30)26(35-29(38)19-6-7-32-24(10-19)17-2-3-17)11-22(16)20-9-21(14-31-13-20)25-12-27(34-15-33-25)36-28(37)18-4-5-18/h6-15,17-18H,2-5H2,1H3,(H,35,38)(H,33,34,36,37) NLCHJILWACNFTR-UHFFFAOYSA-N 745916 US12319655, Example 398 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745916&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929607 518818652 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533535 Cc1cc(F)c(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C30H27F2N5O2/c1-17-10-24(31)25(36-29(39)20-7-8-34-26(12-20)30(2,3)32)14-23(17)22-11-21(15-33-16-22)19-6-9-35-27(13-19)37-28(38)18-4-5-18/h6-16,18H,4-5H2,1-3H3,(H,36,39)(H,35,37,38) JINJBTGRACPYLJ-UHFFFAOYSA-N 745917 US12319655, Example 399 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745917 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745917&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930166 518818653 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533539 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cc(-c2ccnc3[nH]ncc23)cnn1 InChI=1S/C26H22FN7O/c1-15-4-5-18(32-25(35)16-6-8-28-23(11-16)26(2,3)27)12-20(15)22-10-17(13-30-33-22)19-7-9-29-24-21(19)14-31-34-24/h4-14H,1-3H3,(H,32,35)(H,29,31,34) KFOPEQDUJDFOLA-UHFFFAOYSA-N 745918 US12319655, Example 400 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745918 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745918&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930388 518818654 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533543 COC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)cc(OCCO)n2)ccn1 InChI=1S/C30H30FN5O5/c1-18-5-6-22(34-28(38)20-8-9-32-25(14-20)30(2,3)31)17-23(18)21-13-24(35-27(16-21)41-12-11-37)19-7-10-33-26(15-19)36-29(39)40-4/h5-10,13-17,37H,11-12H2,1-4H3,(H,34,38)(H,33,36,39) ACFMCNAREVECLV-UHFFFAOYSA-N 745919 US12319655, Example 401 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745919 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745919&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930566 518818655 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533547 COC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)cnc3C)c2)ccn1 InChI=1S/C28H26FN5O3/c1-17-23(15-22(16-32-17)33-26(35)21-9-10-30-24(13-21)28(2,3)29)20-7-5-6-18(12-20)19-8-11-31-25(14-19)34-27(36)37-4/h5-16H,1-4H3,(H,33,35)(H,31,34,36) DJWBTGQVNORGKY-UHFFFAOYSA-N 745920 US12319655, Example 402 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745920 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745920&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930453 518818656 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533551 COC(=O)Nc1cc(-c2ccnc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)n2)ccn1 InChI=1S/C27H25FN6O3/c1-16-5-6-19(32-25(35)18-8-10-29-22(13-18)27(2,3)28)15-20(16)24-31-12-9-21(33-24)17-7-11-30-23(14-17)34-26(36)37-4/h5-15H,1-4H3,(H,32,35)(H,30,34,36) KMMBEYFQXJKECQ-UHFFFAOYSA-N 745921 US12319655, Example 403 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745921 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745921&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930207 518818657 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533555 COC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)cnc3C)c2)ncn1 InChI=1S/C27H25FN6O3/c1-16-21(12-20(14-30-16)33-25(35)19-8-9-29-23(11-19)27(2,3)28)17-6-5-7-18(10-17)22-13-24(32-15-31-22)34-26(36)37-4/h5-15H,1-4H3,(H,33,35)(H,31,32,34,36) GWBVPUGPMSZQLT-UHFFFAOYSA-N 745922 US12319655, Example 404 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745922&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929331 518818658 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533559 COC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C5(C#N)CC5)c4)ccc3C)c2)ncn1 InChI=1S/C28H23N7O3/c1-17-3-4-21(34-26(36)18-5-8-31-24(10-18)28(15-29)6-7-28)11-22(17)19-9-20(14-30-13-19)23-12-25(33-16-32-23)35-27(37)38-2/h3-5,8-14,16H,6-7H2,1-2H3,(H,34,36)(H,32,33,35,37) UPCMYAGEZZXWKX-UHFFFAOYSA-N 745923 US12319655, Example 405 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745923&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929706 518818659 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533563 Cc1ncc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C28H26FN7O2/c1-16-22(10-21(14-32-16)35-27(38)18-6-7-31-24(9-18)28(2,3)29)19-8-20(13-30-12-19)23-11-25(34-15-33-23)36-26(37)17-4-5-17/h6-15,17H,4-5H2,1-3H3,(H,35,38)(H,33,34,36,37) NZSPMTQCVGNBSJ-UHFFFAOYSA-N 745924 US12319655, Example 406 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745924 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745924&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929779 518818660 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533567 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cnc3ccccn23)c1 InChI=1S/C29H24N6O/c1-19-24(20-7-6-8-21(13-20)25-17-33-27-9-4-5-12-35(25)27)15-23(16-32-19)34-28(36)22-10-11-31-26(14-22)29(2,3)18-30/h4-17H,1-3H3,(H,34,36) HGKDNQMRZSLZCM-UHFFFAOYSA-N 745925 US12319655, Example 407 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745925 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745925&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929582 518818661 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533571 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)c(F)cc3C)c2)ccn1 InChI=1S/C28H25F2N5O2/c1-16-9-22(29)23(35-26(36)18-6-8-34-25(12-18)28(2,3)30)13-21(16)20-10-19(14-32-15-20)17-5-7-33-24(11-17)27(37)31-4/h5-15H,1-4H3,(H,31,37)(H,35,36) FIWSPKRFRVATEJ-UHFFFAOYSA-N 745926 US12319655, Example 408 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745926&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929341 518818662 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533575 COC(=O)Nc1cc(-c2cnnc(-c3cc(NC(=O)c4cn(C(C)C)nn4)ccc3C)c2)ccn1 InChI=1S/C24H24N8O3/c1-14(2)32-13-21(30-31-32)23(33)27-18-6-5-15(3)19(11-18)20-9-17(12-26-29-20)16-7-8-25-22(10-16)28-24(34)35-4/h5-14H,1-4H3,(H,27,33)(H,25,28,34) ZELLYXDSJZXDSZ-UHFFFAOYSA-N 745927 US12319655, Example 409 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745927 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745927&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024570 518818663 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533579 Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C29H26N8O2/c1-17-23(10-22(14-33-17)36-28(39)19-6-7-32-25(9-19)29(2,3)15-30)20-8-21(13-31-12-20)24-11-26(35-16-34-24)37-27(38)18-4-5-18/h6-14,16,18H,4-5H2,1-3H3,(H,36,39)(H,34,35,37,38) KQCIJHFYGHFYGU-UHFFFAOYSA-N 745928 US12319655, Example 410 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745928 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745928&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930215 518818664 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533583 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cncc(-c2cc(N)ncn2)c1 InChI=1S/C25H23FN6O/c1-15-4-5-19(32-24(33)16-6-7-29-22(9-16)25(2,3)26)10-20(15)17-8-18(13-28-12-17)21-11-23(27)31-14-30-21/h4-14H,1-3H3,(H,32,33)(H2,27,30,31) MFADHPBJWQTCGG-UHFFFAOYSA-N 745929 US12319655, Example 411 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745929 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745929&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930458 518818665 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533587 Cc1ccc(NC(=O)c2cn(C(C)C)nn2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C26H26N8O2/c1-15(2)34-13-23(32-33-34)26(36)30-20-7-4-16(3)21(9-20)18-8-19(12-27-11-18)22-10-24(29-14-28-22)31-25(35)17-5-6-17/h4,7-15,17H,5-6H2,1-3H3,(H,30,36)(H,28,29,31,35) NEKRVBTWARKAPJ-UHFFFAOYSA-N 745930 US12319655, Example 412 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745930 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745930&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930654 518818666 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533591 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)c2)ccn1 InChI=1S/C28H26FN5O2/c1-17-5-6-22(34-26(35)19-8-10-33-25(13-19)28(2,3)29)14-23(17)21-11-20(15-31-16-21)18-7-9-32-24(12-18)27(36)30-4/h5-16H,1-4H3,(H,30,36)(H,34,35) OAEIYXHVKOMNDL-UHFFFAOYSA-N 745931 US12319655, Example 413 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745931 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745931&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929970 518818667 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533595 COC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)c2)ncn1 InChI=1S/C28H25N7O3/c1-17-5-6-21(34-26(36)18-7-8-31-24(10-18)28(2,3)15-29)11-22(17)19-9-20(14-30-13-19)23-12-25(33-16-32-23)35-27(37)38-4/h5-14,16H,1-4H3,(H,34,36)(H,32,33,35,37) IPXRXJUEYQSVDI-UHFFFAOYSA-N 745932 US12319655, Example 414 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745932 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745932&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929287 518818668 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533599 COC(=O)Nc1cc(-c2cccc(-c3cc(NC(=O)Cn4cc(C(C)C)nn4)cnc3C)c2)ccn1 InChI=1S/C26H27N7O3/c1-16(2)23-14-33(32-31-23)15-25(34)29-21-12-22(17(3)28-13-21)20-7-5-6-18(10-20)19-8-9-27-24(11-19)30-26(35)36-4/h5-14,16H,15H2,1-4H3,(H,29,34)(H,27,30,35) WOCVUMSYLIYAPW-UHFFFAOYSA-N 745933 US12319655, Example 415 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745933&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930544 518818669 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533603 COC(=O)Nc1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)nc(C)n2)ccn1 InChI=1S/C28H27FN6O3/c1-16-6-7-20(34-26(36)19-9-10-30-24(12-19)28(3,4)29)14-21(16)23-15-22(32-17(2)33-23)18-8-11-31-25(13-18)35-27(37)38-5/h6-15H,1-5H3,(H,34,36)(H,31,35,37) LZEFWSJYMLFGNI-UHFFFAOYSA-N 745934 US12319655, Example 416 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745934&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929736 518818670 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533607 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C30H28FN5O2/c1-18-4-7-24(35-29(38)21-9-10-33-26(13-21)30(2,3)31)15-25(18)23-12-22(16-32-17-23)20-8-11-34-27(14-20)36-28(37)19-5-6-19/h4,7-17,19H,5-6H2,1-3H3,(H,35,38)(H,34,36,37) YVOKZKYESABMBD-UHFFFAOYSA-N 745935 US12319655, Example 417 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745935&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930112 518818671 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533611 Cc1cc(F)c(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C31H27FN6O2/c1-18-10-25(32)26(37-30(40)21-7-8-35-27(12-21)31(2,3)17-33)14-24(18)23-11-22(15-34-16-23)20-6-9-36-28(13-20)38-29(39)19-4-5-19/h6-16,19H,4-5H2,1-3H3,(H,37,40)(H,36,38,39) CDUPGLJVEIKTGX-UHFFFAOYSA-N 745936 US12319655, Example 418 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745936&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930133 518818672 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533615 Cc1ccc(NC(=O)c2ccnc(C(C)(F)F)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C28H24F2N6O2/c1-16-3-6-21(35-27(38)18-7-8-32-24(10-18)28(2,29)30)11-22(16)19-9-20(14-31-13-19)23-12-25(34-15-33-23)36-26(37)17-4-5-17/h3,6-15,17H,4-5H2,1-2H3,(H,35,38)(H,33,34,36,37) MARHQNPQRBMVHV-UHFFFAOYSA-N 745937 US12319655, Example 419 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745937&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929541 518818673 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533619 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cncc(-c2cc(NC(=O)C(C)C)ncn2)c1 InChI=1S/C30H29N7O2/c1-18(2)28(38)37-27-13-25(34-17-35-27)22-10-21(14-32-15-22)24-12-23(7-6-19(24)3)36-29(39)20-8-9-33-26(11-20)30(4,5)16-31/h6-15,17-18H,1-5H3,(H,36,39)(H,34,35,37,38) ZYWOWSGMZNTESW-UHFFFAOYSA-N 745938 US12319655, Example 420 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745938&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929610 518818674 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533623 Cc1ccc(NC(=O)c2cc(C3CC3)on2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C27H24N6O3/c1-15-2-7-20(31-27(35)23-10-24(36-33-23)16-3-4-16)9-21(15)18-8-19(13-28-12-18)22-11-25(30-14-29-22)32-26(34)17-5-6-17/h2,7-14,16-17H,3-6H2,1H3,(H,31,35)(H,29,30,32,34) CKASLCWKWWXASF-UHFFFAOYSA-N 745939 US12319655, Example 421 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745939&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930257 518818675 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533627 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cncc(-c2cc(N)ncn2)c1 InChI=1S/C26H23N7O/c1-16-4-5-20(33-25(34)17-6-7-30-23(9-17)26(2,3)14-27)10-21(16)18-8-19(13-29-12-18)22-11-24(28)32-15-31-22/h4-13,15H,1-3H3,(H,33,34)(H2,28,31,32) UJHZLBYHAUDRKS-UHFFFAOYSA-N 745940 US12319655, Example 422 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745940&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930723 518818676 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533631 Cc1cc(F)c(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C29H26F2N6O2/c1-16-8-22(30)24(36-28(39)18-6-7-33-25(10-18)29(2,3)31)11-21(16)19-9-20(14-32-13-19)23-12-26(35-15-34-23)37-27(38)17-4-5-17/h6-15,17H,4-5H2,1-3H3,(H,36,39)(H,34,35,37,38) CIYORAOFNIYYCE-UHFFFAOYSA-N 745941 US12319655, Example 423 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745941&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929555 518818677 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533635 Cc1cc(F)c(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C30H26FN7O2/c1-17-8-23(31)25(37-29(40)19-6-7-34-26(10-19)30(2,3)15-32)11-22(17)20-9-21(14-33-13-20)24-12-27(36-16-35-24)38-28(39)18-4-5-18/h6-14,16,18H,4-5H2,1-3H3,(H,37,40)(H,35,36,38,39) WWLUHIBKGWLQJQ-UHFFFAOYSA-N 745942 US12319655, Example 424 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745942&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930310 518818678 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533639 COC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)c2)ncn1 InChI=1S/C27H25FN6O3/c1-16-5-6-20(33-25(35)17-7-8-30-23(10-17)27(2,3)28)11-21(16)18-9-19(14-29-13-18)22-12-24(32-15-31-22)34-26(36)37-4/h5-15H,1-4H3,(H,33,35)(H,31,32,34,36) WCXMATBNMULZEQ-UHFFFAOYSA-N 745943 US12319655, Example 425 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745943&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930312 518818679 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533643 Cc1ccc(NC(=O)Cn2cc(C(C)C)nn2)cc1-c1cncc(-c2cc(N)ncn2)c1 InChI=1S/C23H24N8O/c1-14(2)21-11-31(30-29-21)12-23(32)28-18-5-4-15(3)19(7-18)16-6-17(10-25-9-16)20-8-22(24)27-13-26-20/h4-11,13-14H,12H2,1-3H3,(H,28,32)(H2,24,26,27) USXZNHDKOJTVPZ-UHFFFAOYSA-N 745944 US12319655, Example 426 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745944&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929721 518818680 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533647 CNC(=O)c1cc(-c2nccc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)c(F)cc3C)n2)ccn1 InChI=1S/C27H24F2N6O2/c1-15-11-19(28)21(35-25(36)17-6-9-32-23(13-17)27(2,3)29)14-18(15)20-7-10-33-24(34-20)16-5-8-31-22(12-16)26(37)30-4/h5-14H,1-4H3,(H,30,37)(H,35,36) SHJIPHPNUNPQTH-UHFFFAOYSA-N 745945 US12319655, Example 427 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745945&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930546 518818681 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533651 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)nc(C)n2)ccn1 InChI=1S/C28H27FN6O2/c1-16-6-7-20(35-26(36)19-9-11-32-25(13-19)28(3,4)29)14-21(16)23-15-22(33-17(2)34-23)18-8-10-31-24(12-18)27(37)30-5/h6-15H,1-5H3,(H,30,37)(H,35,36) DAMRGDQJZVNADN-UHFFFAOYSA-N 745946 US12319655, Example 428 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745946&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930581 518818682 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533655 Cc1ccc(NC(=O)c2ccnc(C(F)F)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C27H22F2N6O2/c1-15-2-5-20(34-27(37)17-6-7-31-23(9-17)25(28)29)10-21(15)18-8-19(13-30-12-18)22-11-24(33-14-32-22)35-26(36)16-3-4-16/h2,5-14,16,25H,3-4H2,1H3,(H,34,37)(H,32,33,35,36) SAUIVEDSXFMKIX-UHFFFAOYSA-N 745947 US12319655, Example 429 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745947&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930658 518818683 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533659 Cc1ccc(NC(=O)c2cnn(C3CC3)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C27H25N7O2/c1-16-2-5-21(32-27(36)20-13-31-34(14-20)22-6-7-22)9-23(16)18-8-19(12-28-11-18)24-10-25(30-15-29-24)33-26(35)17-3-4-17/h2,5,8-15,17,22H,3-4,6-7H2,1H3,(H,32,36)(H,29,30,33,35) CGNZZIXMDVMOFC-UHFFFAOYSA-N 745948 US12319655, Example 430 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745948&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024711 518818684 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533663 Cc1ccc(NC(=O)c2cc(C(C)(C)C)on2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C28H28N6O3/c1-16-5-8-20(32-27(36)23-11-24(37-34-23)28(2,3)4)10-21(16)18-9-19(14-29-13-18)22-12-25(31-15-30-22)33-26(35)17-6-7-17/h5,8-15,17H,6-7H2,1-4H3,(H,32,36)(H,30,31,33,35) IDNLPUQJWVTSED-UHFFFAOYSA-N 745949 US12319655, Example 431 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745949&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929412 518818685 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533667 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cncc(-c2ccnc3c2CC(=O)N3)c1 InChI=1S/C28H24FN5O2/c1-16-4-5-20(33-27(36)17-6-8-31-24(11-17)28(2,3)29)12-22(16)19-10-18(14-30-15-19)21-7-9-32-26-23(21)13-25(35)34-26/h4-12,14-15H,13H2,1-3H3,(H,33,36)(H,32,34,35) OLHDYKGVNWRIRQ-UHFFFAOYSA-N 745950 US12319655, Example 432 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745950&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930565 518818686 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533671 Cc1ncc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C29H27FN6O2/c1-17-24(13-23(16-34-17)35-28(38)20-7-8-32-25(11-20)29(2,3)30)22-10-21(14-31-15-22)19-6-9-33-26(12-19)36-27(37)18-4-5-18/h6-16,18H,4-5H2,1-3H3,(H,35,38)(H,33,36,37) SONUUCJPVGACDQ-UHFFFAOYSA-N 745951 US12319655, Example 433 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745951&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929262 518818687 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533675 Cc1ccc(NC(=O)c2ccnc(C(C)C)c2)cc1-c1cncc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C29H28N6O2/c1-17(2)25-11-20(8-9-31-25)29(37)34-23-7-4-18(3)24(12-23)21-10-22(15-30-14-21)26-13-27(33-16-32-26)35-28(36)19-5-6-19/h4,7-17,19H,5-6H2,1-3H3,(H,34,37)(H,32,33,35,36) YGHIQODGXJCWMX-UHFFFAOYSA-N 745952 US12319655, Example 434 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745952&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930595 518818688 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533679 COC(=O)Nc1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)c2)ccn1 InChI=1S/C28H26FN5O3/c1-17-5-6-22(33-26(35)19-8-9-31-24(12-19)28(2,3)29)14-23(17)21-11-20(15-30-16-21)18-7-10-32-25(13-18)34-27(36)37-4/h5-16H,1-4H3,(H,33,35)(H,32,34,36) SBWVUBOZDVYOSA-UHFFFAOYSA-N 745953 US12319655, Example 435 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745953&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930482 518818689 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533683 Cc1ccc(NC(=O)c2cc(C3CC3)n(C)n2)cc1-c1nccc(-c2ccnc(NC(=O)C3CC3)c2)n1 InChI=1S/C28H27N7O2/c1-16-3-8-20(31-28(37)23-15-24(17-4-5-17)35(2)34-23)14-21(16)26-30-12-10-22(32-26)19-9-11-29-25(13-19)33-27(36)18-6-7-18/h3,8-15,17-18H,4-7H2,1-2H3,(H,31,37)(H,29,33,36) CSHGGYPKBYLZIR-UHFFFAOYSA-N 745954 US12319655, Example 436 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745954&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930573 518818690 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533687 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3OC)ccn2)ccn1 InChI=1S/C29H26N6O3/c1-29(2,17-30)26-15-20(9-12-34-26)27(36)35-21-5-6-25(38-4)22(16-21)18-7-10-32-23(13-18)19-8-11-33-24(14-19)28(37)31-3/h5-16H,1-4H3,(H,31,37)(H,35,36) AUPBZJYNDQGCIB-UHFFFAOYSA-N 745955 US12319655, Example 437 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745955&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930316 518818691 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533691 COc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cccc(-c2cc(NC(=O)C3CC3)ncn2)c1 InChI=1S/C31H28N6O3/c1-31(2,17-32)27-14-22(11-12-33-27)30(39)36-23-9-10-26(40-3)24(15-23)20-5-4-6-21(13-20)25-16-28(35-18-34-25)37-29(38)19-7-8-19/h4-6,9-16,18-19H,7-8H2,1-3H3,(H,36,39)(H,34,35,37,38) ITDUKZLVFLYFHY-UHFFFAOYSA-N 745956 US12319655, Example 438 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745956&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930530 518818692 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533695 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(F)F)c4)ccc3C)c2)ncn1 InChI=1S/C26H22F2N6O2/c1-15-4-5-19(34-24(35)16-6-7-31-23(9-16)26(2,27)28)10-20(15)17-8-18(13-30-12-17)21-11-22(25(36)29-3)33-14-32-21/h4-14H,1-3H3,(H,29,36)(H,34,35) WHDJEVVPFDFHIH-UHFFFAOYSA-N 745957 US12319655, Example 439 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745957&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930025 518818693 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533699 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(F)F)c4)ccc3C)c2)ccn1 InChI=1S/C27H23F2N5O2/c1-16-4-5-21(34-25(35)18-7-9-33-24(12-18)27(2,28)29)13-22(16)20-10-19(14-31-15-20)17-6-8-32-23(11-17)26(36)30-3/h4-15H,1-3H3,(H,30,36)(H,34,35) ARPJFVPWGZGBCA-UHFFFAOYSA-N 745958 US12319655, Example 440 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745958&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930407 518818694 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533703 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(F)F)c4)ccc3C)ccn2)ccn1 InChI=1S/C27H23F2N5O2/c1-16-4-5-20(34-25(35)19-8-11-33-24(14-19)27(2,28)29)15-21(16)17-6-9-31-22(12-17)18-7-10-32-23(13-18)26(36)30-3/h4-15H,1-3H3,(H,30,36)(H,34,35) ZZAVKKVQZYCTEB-UHFFFAOYSA-N 745959 US12319655, Example 441 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745959&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929520 518818695 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533707 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)c2)ccn1 InChI=1S/C29H26N6O2/c1-18-5-6-23(35-27(36)20-8-10-34-26(13-20)29(2,3)17-30)14-24(18)22-11-21(15-32-16-22)19-7-9-33-25(12-19)28(37)31-4/h5-16H,1-4H3,(H,31,37)(H,35,36) CBLADTUVPFCVDL-UHFFFAOYSA-N 745960 US12319655, Example 442 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745960&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024733 518818696 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533711 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)C)c4)ccc3C)ccn2)ccn1 InChI=1S/C28H27N5O2/c1-17(2)24-15-21(9-12-30-24)27(34)33-22-6-5-18(3)23(16-22)19-7-10-31-25(13-19)20-8-11-32-26(14-20)28(35)29-4/h5-17H,1-4H3,(H,29,35)(H,33,34) NUIXLLGLYHKUMA-UHFFFAOYSA-N 745961 US12319655, Example 443 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745961&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930493 518818697 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533715 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)cnc3C)ccn2)ccn1 InChI=1S/C27H25FN6O2/c1-16-21(17-5-8-30-22(11-17)18-6-9-31-23(12-18)26(36)29-4)14-20(15-33-16)34-25(35)19-7-10-32-24(13-19)27(2,3)28/h5-15H,1-4H3,(H,29,36)(H,34,35) IDUKNUQHHMGTML-UHFFFAOYSA-N 745962 US12319655, Example 444 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745962&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930010 518818698 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533719 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)C)c4)ccc3C)c2)ccn1 InChI=1S/C28H27N5O2/c1-17(2)25-13-20(8-10-31-25)27(34)33-23-6-5-18(3)24(14-23)22-11-21(15-30-16-22)19-7-9-32-26(12-19)28(35)29-4/h5-17H,1-4H3,(H,29,35)(H,33,34) LMGYIYIHJUDMBH-UHFFFAOYSA-N 745963 US12319655, Example 445 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745963&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930651 518818699 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533723 CNC(=O)c1cc(-c2cncc(-c3cc(NC(=O)c4ccnc(C(C)C)c4)ccc3C)c2)ncn1 InChI=1S/C27H26N6O2/c1-16(2)23-10-18(7-8-30-23)26(34)33-21-6-5-17(3)22(11-21)19-9-20(14-29-13-19)24-12-25(27(35)28-4)32-15-31-24/h5-16H,1-4H3,(H,28,35)(H,33,34) KBAZBBSMUNRRLT-UHFFFAOYSA-N 745964 US12319655, Example 446 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745964&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929469 518818700 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533727 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1ccnc(-c2ccnc(C#N)c2)c1 InChI=1S/C27H22FN5O/c1-17-4-5-21(33-26(34)20-8-11-32-25(14-20)27(2,3)28)15-23(17)18-6-10-31-24(13-18)19-7-9-30-22(12-19)16-29/h4-15H,1-3H3,(H,33,34) RCAQPGIYKFRKCD-UHFFFAOYSA-N 745965 US12319655, Example 447 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745965&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930598 518818701 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533731 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1ccnc(-c2ccnc(C(=O)NCCO)c2)c1 InChI=1S/C29H28FN5O3/c1-18-4-5-22(35-27(37)21-8-11-33-26(16-21)29(2,3)30)17-23(18)19-6-9-31-24(14-19)20-7-10-32-25(15-20)28(38)34-12-13-36/h4-11,14-17,36H,12-13H2,1-3H3,(H,34,38)(H,35,37) VBOVDIGPBSIRFD-UHFFFAOYSA-N 745966 US12319655, Example 448 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745966&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930703 518818702 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533735 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)cc(OCCO)n2)ccn1 InChI=1S/C30H30FN5O4/c1-18-5-6-22(35-28(38)20-8-10-34-26(15-20)30(2,3)31)17-23(18)21-14-24(36-27(16-21)40-12-11-37)19-7-9-33-25(13-19)29(39)32-4/h5-10,13-17,37H,11-12H2,1-4H3,(H,32,39)(H,35,38) DHNRISORMJJIEE-UHFFFAOYSA-N 745967 US12319655, Example 449 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745967&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929421 518808297 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533739 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1ccnc(-c2ccnc(C(=O)NC3CN(C)C3)c2)c1 InChI=1S/C31H31FN6O2/c1-19-5-6-23(36-29(39)22-9-12-35-28(15-22)31(2,3)32)16-25(19)20-7-10-33-26(13-20)21-8-11-34-27(14-21)30(40)37-24-17-38(4)18-24/h5-16,24H,17-18H2,1-4H3,(H,36,39)(H,37,40) WOFQAMVEQBLFQH-UHFFFAOYSA-N 745968 US12319655, Example 450 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745968&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024539 518808298 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533743 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1ccnc(-c2ccnc(C(=O)NCC#N)c2)c1 InChI=1S/C29H25FN6O2/c1-18-4-5-22(36-27(37)21-8-12-34-26(16-21)29(2,3)30)17-23(18)19-6-10-32-24(14-19)20-7-11-33-25(15-20)28(38)35-13-9-31/h4-8,10-12,14-17H,13H2,1-3H3,(H,35,38)(H,36,37) JZLXOKDXCZABLR-UHFFFAOYSA-N 745969 US12319655, Example 451 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745969&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024715 518808299 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533747 CNC(=N)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)ccn2)ccn1 InChI=1S/C28H27FN6O/c1-17-5-6-21(35-27(36)20-9-12-34-25(15-20)28(2,3)29)16-22(17)18-7-10-32-23(13-18)19-8-11-33-24(14-19)26(30)31-4/h5-16H,1-4H3,(H2,30,31)(H,35,36) GQUXXXXYFNZOCT-UHFFFAOYSA-N 745970 US12319655, Example 452 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745970&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930246 518808300 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533751 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1ccnc(-c2ccnc(C(=O)NCCN(C)C)c2)c1 InChI=1S/C31H33FN6O2/c1-20-6-7-24(37-29(39)23-10-13-35-28(18-23)31(2,3)32)19-25(20)21-8-11-33-26(16-21)22-9-12-34-27(17-22)30(40)36-14-15-38(4)5/h6-13,16-19H,14-15H2,1-5H3,(H,36,40)(H,37,39) ZJHSUKSHVIGOBK-UHFFFAOYSA-N 745971 US12319655, Example 453 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745971&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024564 518808301 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533755 Cc1ncc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C29H27FN6O2/c1-17-23(15-22(16-34-17)35-28(38)21-8-10-32-25(13-21)29(2,3)30)19-6-9-31-24(12-19)20-7-11-33-26(14-20)36-27(37)18-4-5-18/h6-16,18H,4-5H2,1-3H3,(H,35,38)(H,33,36,37) JTPMAKKCDWXZJV-UHFFFAOYSA-N 745972 US12319655, Example 454 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745972&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929489 518808302 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533759 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C30H28FN5O2/c1-18-4-7-23(35-29(38)22-10-12-33-26(15-22)30(2,3)31)17-24(18)20-8-11-32-25(14-20)21-9-13-34-27(16-21)36-28(37)19-5-6-19/h4,7-17,19H,5-6H2,1-3H3,(H,35,38)(H,34,36,37) RZHYYXPIEGXPMS-UHFFFAOYSA-N 745973 US12319655, Example 455 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745973&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929405 518808303 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533763 Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C31H28N6O2/c1-19-4-7-24(36-30(39)23-10-12-34-27(15-23)31(2,3)18-32)17-25(19)21-8-11-33-26(14-21)22-9-13-35-28(16-22)37-29(38)20-5-6-20/h4,7-17,20H,5-6H2,1-3H3,(H,36,39)(H,35,37,38) SQNMXINAGUMYRF-UHFFFAOYSA-N 745974 US12319655, Example 456 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745974&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024639 518808304 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533767 Cc1ccc(NC(=O)c2ccnc(C3(C#N)CC3)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C31H26N6O2/c1-19-2-5-24(36-30(39)23-8-12-34-27(15-23)31(18-32)9-10-31)17-25(19)21-6-11-33-26(14-21)22-7-13-35-28(16-22)37-29(38)20-3-4-20/h2,5-8,11-17,20H,3-4,9-10H2,1H3,(H,36,39)(H,35,37,38) SRQWGTZFXCTUEF-UHFFFAOYSA-N 745975 US12319655, Example 457 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745975&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930189 518808305 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533771 Cc1ccc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C30H27N5O2/c1-18-2-7-24(34-30(37)23-10-12-31-26(15-23)19-3-4-19)17-25(18)21-8-11-32-27(14-21)22-9-13-33-28(16-22)35-29(36)20-5-6-20/h2,7-17,19-20H,3-6H2,1H3,(H,34,37)(H,33,35,36) ZANHZUGJIXLWRF-UHFFFAOYSA-N 745976 US12319655, Example 458 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745976&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930107 518808306 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533775 Cc1ccc(NC(=O)c2ccnc(C(C)(F)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C29H25F2N5O2/c1-17-3-6-22(35-28(38)21-9-11-33-25(14-21)29(2,30)31)16-23(17)19-7-10-32-24(13-19)20-8-12-34-26(15-20)36-27(37)18-4-5-18/h3,6-16,18H,4-5H2,1-2H3,(H,35,38)(H,34,36,37) KNJMKQHKISRMEI-UHFFFAOYSA-N 745977 US12319655, Example 459 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745977&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929459 518808307 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533779 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C5CC5)c4)ccc3C)ccn2)ccn1 InChI=1S/C28H25N5O2/c1-17-3-6-22(33-27(34)21-9-12-30-24(15-21)18-4-5-18)16-23(17)19-7-10-31-25(13-19)20-8-11-32-26(14-20)28(35)29-2/h3,6-16,18H,4-5H2,1-2H3,(H,29,35)(H,33,34) OFQQNPBEXDJTGV-UHFFFAOYSA-N 745978 US12319655, Example 460 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745978&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024645 518808308 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533783 Cc1ncc(NC(=O)c2ccnc(C3(C#N)CC3)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C30H25N7O2/c1-18-24(15-23(16-35-18)36-29(39)22-6-10-33-26(13-22)30(17-31)7-8-30)20-4-9-32-25(12-20)21-5-11-34-27(14-21)37-28(38)19-2-3-19/h4-6,9-16,19H,2-3,7-8H2,1H3,(H,36,39)(H,34,37,38) VMNVBEQQJJURNF-UHFFFAOYSA-N 745979 US12319655, Example 461 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745979&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930326 518808309 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533787 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C5CC5)c4)cnc3C)ccn2)ccn1 InChI=1S/C27H24N6O2/c1-16-22(18-5-8-30-24(11-18)19-6-9-31-25(12-19)27(35)28-2)14-21(15-32-16)33-26(34)20-7-10-29-23(13-20)17-3-4-17/h5-15,17H,3-4H2,1-2H3,(H,28,35)(H,33,34) YZPBGFRJBAPVFN-UHFFFAOYSA-N 745980 US12319655, Example 462 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745980&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930125 518808310 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533791 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(F)F)c4)cnc3C)ccn2)ccn1 InChI=1S/C26H22F2N6O2/c1-15-20(16-4-7-30-21(10-16)17-5-8-31-22(11-17)25(36)29-3)13-19(14-33-15)34-24(35)18-6-9-32-23(12-18)26(2,27)28/h4-14H,1-3H3,(H,29,36)(H,34,35) BCUFMYOXQMRXOB-UHFFFAOYSA-N 745981 US12319655, Example 463 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745981&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024585 518808311 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533795 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C5(C#N)CC5)c4)cnc3C)ccn2)ccn1 InChI=1S/C28H23N7O2/c1-17-22(18-3-8-31-23(11-18)19-4-9-32-24(12-19)27(37)30-2)14-21(15-34-17)35-26(36)20-5-10-33-25(13-20)28(16-29)6-7-28/h3-5,8-15H,6-7H2,1-2H3,(H,30,37)(H,35,36) OBXGMXIUFAXGAZ-UHFFFAOYSA-N 745982 US12319655, Example 464 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745982&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024669 518808312 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533799 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)C)c4)cnc3C)ccn2)ccn1 InChI=1S/C27H26N6O2/c1-16(2)23-13-20(7-10-29-23)26(34)33-21-14-22(17(3)32-15-21)18-5-8-30-24(11-18)19-6-9-31-25(12-19)27(35)28-4/h5-16H,1-4H3,(H,28,35)(H,33,34) ZNZZKTZTJFEJLZ-UHFFFAOYSA-N 745983 US12319655, Example 465 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745983&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024672 518808313 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533803 Cc1ncc(NC(=O)c2ccnc(C(C)(F)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C28H24F2N6O2/c1-16-22(14-21(15-34-16)35-27(38)20-7-9-32-24(12-20)28(2,29)30)18-5-8-31-23(11-18)19-6-10-33-25(13-19)36-26(37)17-3-4-17/h5-15,17H,3-4H2,1-2H3,(H,35,38)(H,33,36,37) KOCSMLXCYBYXEQ-UHFFFAOYSA-N 745984 US12319655, Example 466 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745984&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929535 518808314 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533807 Cc1ccc(NC(=O)c2ccnc(C(C)C)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C30H29N5O2/c1-18(2)26-15-23(10-12-31-26)30(37)34-24-7-4-19(3)25(17-24)21-8-11-32-27(14-21)22-9-13-33-28(16-22)35-29(36)20-5-6-20/h4,7-18,20H,5-6H2,1-3H3,(H,34,37)(H,33,35,36) FKQHKLKPDFEFPA-UHFFFAOYSA-N 745985 US12319655, Example 467 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745985&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929581 518808315 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533811 Cc1ncc(NC(=O)c2ccnc(C(C)C)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C29H28N6O2/c1-17(2)25-13-22(8-10-30-25)29(37)34-23-15-24(18(3)33-16-23)20-6-9-31-26(12-20)21-7-11-32-27(14-21)35-28(36)19-4-5-19/h6-17,19H,4-5H2,1-3H3,(H,34,37)(H,32,35,36) RJNVDHJQQBRRQL-UHFFFAOYSA-N 745986 US12319655, Example 468 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745986&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930183 518808316 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533815 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)c(F)cn2)ccn1 InChI=1S/C28H25F2N5O2/c1-16-5-6-19(35-26(36)18-8-10-33-25(12-18)28(2,3)30)13-20(16)21-14-23(34-15-22(21)29)17-7-9-32-24(11-17)27(37)31-4/h5-15H,1-4H3,(H,31,37)(H,35,36) QWAAKJRXKKZBCE-UHFFFAOYSA-N 745987 US12319655, Example 469 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745987&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929950 518808317 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533819 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)cc(C)n2)ccn1 InChI=1S/C29H28FN5O2/c1-17-6-7-22(35-27(36)20-9-11-33-26(15-20)29(3,4)30)16-23(17)21-12-18(2)34-24(14-21)19-8-10-32-25(13-19)28(37)31-5/h6-16H,1-5H3,(H,31,37)(H,35,36) ZAUCOLUXNCUMND-UHFFFAOYSA-N 745988 US12319655, Example 470 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745988&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929530 518808318 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533823 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C(F)(F)F)ccn2)ccn1 InChI=1S/C28H23F4N5O2/c1-27(2,29)24-14-18(8-11-36-24)25(38)37-19-4-5-21(28(30,31)32)20(15-19)16-6-9-34-22(12-16)17-7-10-35-23(13-17)26(39)33-3/h4-15H,1-3H3,(H,33,39)(H,37,38) BVXFRRZHUXWTPC-UHFFFAOYSA-N 745989 US12319655, Example 471 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745989&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929817 518808319 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533827 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)c(C)cn2)ccn1 InChI=1S/C29H28FN5O2/c1-17-6-7-21(35-27(36)20-9-11-33-26(13-20)29(3,4)30)14-22(17)23-15-24(34-16-18(23)2)19-8-10-32-25(12-19)28(37)31-5/h6-16H,1-5H3,(H,31,37)(H,35,36) GTESUUANQSWLDJ-UHFFFAOYSA-N 745990 US12319655, Example 472 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745990&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929381 518808320 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533831 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)cnn2)ccn1 InChI=1S/C27H25FN6O2/c1-16-5-6-20(33-25(35)18-8-10-31-24(13-18)27(2,3)28)14-21(16)19-12-22(34-32-15-19)17-7-9-30-23(11-17)26(36)29-4/h5-15H,1-4H3,(H,29,36)(H,33,35) AAGVZJLATQKLLZ-UHFFFAOYSA-N 745991 US12319655, Example 473 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745991&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930155 518808321 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533835 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)ncn2)ccn1 InChI=1S/C27H25FN6O2/c1-16-5-6-19(34-25(35)18-8-10-31-24(12-18)27(2,3)28)13-20(16)22-14-21(32-15-33-22)17-7-9-30-23(11-17)26(36)29-4/h5-15H,1-4H3,(H,29,36)(H,34,35) BXZBXXKGTYCKRH-UHFFFAOYSA-N 745992 US12319655, Example 474 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745992&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024540 518808322 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533839 CNC(=O)c1cc(-c2cc(-c3cc(F)cc(NC(=O)c4ccnc(C(C)(C)F)c4)c3F)ccn2)ccn1 InChI=1S/C27H22F3N5O2/c1-27(2,30)23-12-17(6-9-34-23)25(36)35-21-14-18(28)13-19(24(21)29)15-4-7-32-20(10-15)16-5-8-33-22(11-16)26(37)31-3/h4-14H,1-3H3,(H,31,37)(H,35,36) PAZBSRYJOZVGCL-UHFFFAOYSA-N 745993 US12319655, Example 475 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745993&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929340 518808323 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533843 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1ccnc(-c2ccnc(C(N)=O)c2)c1 InChI=1S/C27H24FN5O2/c1-16-4-5-20(33-26(35)19-8-11-32-24(14-19)27(2,3)28)15-21(16)17-6-9-30-22(12-17)18-7-10-31-23(13-18)25(29)34/h4-15H,1-3H3,(H2,29,34)(H,33,35) OEUAOINNJJCTOK-UHFFFAOYSA-N 745994 US12319655, Example 476 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745994&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929999 518808324 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533847 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4cnnc(C(F)(F)F)c4)ccc3C)ccn2)ccn1 InChI=1S/C25H19F3N6O2/c1-14-3-4-18(33-23(35)17-11-22(25(26,27)28)34-32-13-17)12-19(14)15-5-7-30-20(9-15)16-6-8-31-21(10-16)24(36)29-2/h3-13H,1-2H3,(H,29,36)(H,33,35) ZKJKEZPOKXABFA-UHFFFAOYSA-N 745995 US12319655, Example 477 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745995&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024741 518808325 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533851 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)cc(F)c3F)ccn2)ccn1 InChI=1S/C27H22F3N5O2/c1-27(2,30)23-12-17(6-9-34-23)25(36)35-18-13-19(24(29)20(28)14-18)15-4-7-32-21(10-15)16-5-8-33-22(11-16)26(37)31-3/h4-14H,1-3H3,(H,31,37)(H,35,36) UWBGRLWEEBOBRS-UHFFFAOYSA-N 745996 US12319655, Example 478 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745996&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024704 518808326 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533855 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3F)ccn2)ccn1 InChI=1S/C27H23F2N5O2/c1-27(2,29)24-14-18(8-11-33-24)25(35)34-19-4-5-21(28)20(15-19)16-6-9-31-22(12-16)17-7-10-32-23(13-17)26(36)30-3/h4-15H,1-3H3,(H,30,36)(H,34,35) NMFQZWVFUOSAGD-UHFFFAOYSA-N 745997 US12319655, Example 479 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745997&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930072 518808327 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533859 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)cc(F)c3C)ccn2)ccn1 InChI=1S/C28H25F2N5O2/c1-16-21(17-5-8-32-23(11-17)18-6-9-33-24(12-18)27(37)31-4)14-20(15-22(16)29)35-26(36)19-7-10-34-25(13-19)28(2,3)30/h5-15H,1-4H3,(H,31,37)(H,35,36) DWRPVJRSZFWCOX-UHFFFAOYSA-N 745998 US12319655, Example 480 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745998&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930594 518808328 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533863 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccn3)ccn2)ccn1 InChI=1S/C26H23FN6O2/c1-26(2,27)23-14-18(6-10-32-23)24(34)33-19-7-11-30-21(15-19)16-4-8-29-20(12-16)17-5-9-31-22(13-17)25(35)28-3/h4-15H,1-3H3,(H,28,35)(H,30,33,34) HZZKBWKSQJAPSI-UHFFFAOYSA-N 745999 US12319655, Example 481 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=745999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=745999&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930609 518808329 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533867 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)c(F)cc3F)ccn2)ccn1 InChI=1S/C27H22F3N5O2/c1-27(2,30)24-12-17(6-9-34-24)25(36)35-22-13-18(19(28)14-20(22)29)15-4-7-32-21(10-15)16-5-8-33-23(11-16)26(37)31-3/h4-14H,1-3H3,(H,31,37)(H,35,36) BICWYVYJYVUJSQ-UHFFFAOYSA-N 746000 US12319655, Example 482 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746000&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929671 518808330 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533871 Cc1cc(-c2cc(NC(=O)c3ccnc(C(C)(C)F)c3)ccc2C)cc(-c2ccnc(C#N)c2)n1 InChI=1S/C28H24FN5O/c1-17-5-6-22(34-27(35)20-8-10-32-26(14-20)28(3,4)29)15-24(17)21-11-18(2)33-25(13-21)19-7-9-31-23(12-19)16-30/h5-15H,1-4H3,(H,34,35) VLRRAGJZMOJBIW-UHFFFAOYSA-N 746001 US12319655, Example 483 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746001&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929982 518808331 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533875 Cc1cc(-c2cc(NC(=O)c3ccnc(C(C)(C)F)c3)ccc2C)cc(-c2ccnc(C(N)=O)c2)n1 InChI=1S/C28H26FN5O2/c1-16-5-6-21(34-27(36)19-8-10-32-25(14-19)28(3,4)29)15-22(16)20-11-17(2)33-23(13-20)18-7-9-31-24(12-18)26(30)35/h5-15H,1-4H3,(H2,30,35)(H,34,36) BZFVHMFDVVDGNA-UHFFFAOYSA-N 746002 US12319655, Example 484 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746002&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024742 518808332 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533879 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3Cl)ccn2)ccn1 InChI=1S/C27H23ClFN5O2/c1-27(2,29)24-14-18(8-11-33-24)25(35)34-19-4-5-21(28)20(15-19)16-6-9-31-22(12-16)17-7-10-32-23(13-17)26(36)30-3/h4-15H,1-3H3,(H,30,36)(H,34,35) NUXLYABWGDYIPY-UHFFFAOYSA-N 746003 US12319655, Example 485 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746003&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929637 518808333 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533883 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cnnc(-c2ccnc(C(N)=O)c2)c1 InChI=1S/C26H23FN6O2/c1-15-4-5-19(32-25(35)17-7-9-30-23(12-17)26(2,3)27)13-20(15)18-11-21(33-31-14-18)16-6-8-29-22(10-16)24(28)34/h4-14H,1-3H3,(H2,28,34)(H,32,35) SIJOJYZPFIHFAD-UHFFFAOYSA-N 746004 US12319655, Example 486 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746004&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930664 518808334 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533887 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C5(F)CC5)c4)ccc3C)ccn2)ccn1 InChI=1S/C28H24FN5O2/c1-17-3-4-21(34-26(35)20-7-12-33-25(15-20)28(29)8-9-28)16-22(17)18-5-10-31-23(13-18)19-6-11-32-24(14-19)27(36)30-2/h3-7,10-16H,8-9H2,1-2H3,(H,30,36)(H,34,35) WUSFPCUDBZVINW-UHFFFAOYSA-N 746005 US12319655, Example 487 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746005&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929324 518808335 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533891 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cc(-c2ccnc(C(N)=O)c2)ncn1 InChI=1S/C26H23FN6O2/c1-15-4-5-18(33-25(35)17-7-9-30-23(11-17)26(2,3)27)12-19(15)21-13-20(31-14-32-21)16-6-8-29-22(10-16)24(28)34/h4-14H,1-3H3,(H2,28,34)(H,33,35) BJNDSTJFVHNBOW-UHFFFAOYSA-N 746006 US12319655, Example 488 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746006&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024533 518808336 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533895 [2H]C([2H])([2H])NC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)ccn2)ccn1 InChI=1S/C28H26FN5O2/c1-17-5-6-21(34-26(35)20-9-12-33-25(15-20)28(2,3)29)16-22(17)18-7-10-31-23(13-18)19-8-11-32-24(14-19)27(36)30-4/h5-16H,1-4H3,(H,30,36)(H,34,35)/i4D3 IOHMOFMPUPAQNC-GKOSEXJESA-N 746007 US12319655, Example 489 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746007&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024566 518808337 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533899 Cc1ccc(NC(=O)c2ccnc(C(C)(C)F)c2)cc1-c1cc(-c2ccnc(C(N)=O)c2)ncc1F InChI=1S/C27H23F2N5O2/c1-15-4-5-18(34-26(36)17-7-9-32-24(11-17)27(2,3)29)12-19(15)20-13-22(33-14-21(20)28)16-6-8-31-23(10-16)25(30)35/h4-14H,1-3H3,(H2,30,35)(H,34,36) QSGSTNUAFQGSLS-UHFFFAOYSA-N 746008 US12319655, Example 490 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746008&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929927 518808338 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533903 CC(C)(F)c1cc(C(=O)Nc2ccc(F)c(-c3ccnc(-c4ccnc(C(N)=O)c4)c3)c2)ccn1 InChI=1S/C26H21F2N5O2/c1-26(2,28)23-13-17(7-10-32-23)25(35)33-18-3-4-20(27)19(14-18)15-5-8-30-21(11-15)16-6-9-31-22(12-16)24(29)34/h3-14H,1-2H3,(H2,29,34)(H,33,35) VCHOXCHWXNAOJB-UHFFFAOYSA-N 746009 US12319655, Example 491 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746009&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929654 518808339 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533907 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4cnnc(C(C)(F)F)c4)ccc3C)ccn2)ccn1 InChI=1S/C26H22F2N6O2/c1-15-4-5-19(33-24(35)18-12-23(26(2,27)28)34-32-14-18)13-20(15)16-6-8-30-21(10-16)17-7-9-31-22(11-17)25(36)29-3/h4-14H,1-3H3,(H,29,36)(H,33,35) RBRZMDHRACFCDT-UHFFFAOYSA-N 746010 US12319655, Example 492 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746010&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024740 518808340 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533911 [2H]C([2H])([2H])NC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ccc3C)cc(C)n2)ccn1 InChI=1S/C29H28FN5O2/c1-17-6-7-22(35-27(36)20-9-11-33-26(15-20)29(3,4)30)16-23(17)21-12-18(2)34-24(14-21)19-8-10-32-25(13-19)28(37)31-5/h6-16H,1-5H3,(H,31,37)(H,35,36)/i5D3 ZAUCOLUXNCUMND-VPYROQPTSA-N 746011 US12319655, Example 493 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746011&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024714 518808341 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533915 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)n4)ccc3C)ccn2)ccn1 InChI=1S/C27H25FN6O2/c1-16-5-6-19(33-25(36)21-9-12-32-26(34-21)27(2,3)28)15-20(16)17-7-10-30-22(13-17)18-8-11-31-23(14-18)24(35)29-4/h5-15H,1-4H3,(H,29,35)(H,33,36) DRTXTJKWXQKBHA-UHFFFAOYSA-N 746012 US12319655, Example 494 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746012&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929447 518808342 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533919 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4cnnc(C(C)(C)F)c4)ccc3C)ccn2)ccn1 InChI=1S/C27H25FN6O2/c1-16-5-6-20(33-25(35)19-13-24(27(2,3)28)34-32-15-19)14-21(16)17-7-9-30-22(11-17)18-8-10-31-23(12-18)26(36)29-4/h5-15H,1-4H3,(H,29,36)(H,33,35) IPWVIVFNWBEPQE-UHFFFAOYSA-N 746013 US12319655, Example 495 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 750 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746013&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024738 518808343 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533923 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C5(F)CC5)c4)ccc3C)cc(C)n2)ccn1 InChI=1S/C29H26FN5O2/c1-17-4-5-22(35-27(36)20-7-11-33-26(15-20)29(30)8-9-29)16-23(17)21-12-18(2)34-24(14-21)19-6-10-32-25(13-19)28(37)31-3/h4-7,10-16H,8-9H2,1-3H3,(H,31,37)(H,35,36) XJYCWLCOVAGBTI-UHFFFAOYSA-N 746014 US12319655, Example 496 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746014&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930495 518808344 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533927 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)c(F)cc3C)ccn2)ccn1 InChI=1S/C28H25F2N5O2/c1-16-11-21(29)23(35-26(36)19-7-10-34-25(14-19)28(2,3)30)15-20(16)17-5-8-32-22(12-17)18-6-9-33-24(13-18)27(37)31-4/h5-15H,1-4H3,(H,31,37)(H,35,36) QKDQIDDVIWNFHO-UHFFFAOYSA-N 746015 US12319655, Example 497 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746015&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930492 518808345 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533931 [2H]C([2H])([2H])NC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C5(F)CC5)c4)ccc3C)cc(C)n2)ccn1 InChI=1S/C29H26FN5O2/c1-17-4-5-22(35-27(36)20-7-11-33-26(15-20)29(30)8-9-29)16-23(17)21-12-18(2)34-24(14-21)19-6-10-32-25(13-19)28(37)31-3/h4-7,10-16H,8-9H2,1-3H3,(H,31,37)(H,35,36)/i3D3 XJYCWLCOVAGBTI-HPRDVNIFSA-N 746016 US12319655, Example 498 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746016&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 169024726 518808346 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533935 CNC(=O)c1cc(-c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)F)c4)ncc3C)ccn2)ccn1 InChI=1S/C27H25FN6O2/c1-16-15-33-24(34-25(35)19-7-10-32-23(13-19)27(2,3)28)14-20(16)17-5-8-30-21(11-17)18-6-9-31-22(12-18)26(36)29-4/h5-15H,1-4H3,(H,29,36)(H,33,34,35) GCGOEJKINPEPPO-UHFFFAOYSA-N 746017 US12319655, Example 499 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746017&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929810 518808347 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533939 Cc1ccc(NC(=O)c2cn(C)nc2C(F)(F)F)cc1-c1cncc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C27H23F3N6O2/c1-15-3-6-20(33-26(38)22-14-36(2)35-24(22)27(28,29)30)11-21(15)19-9-18(12-31-13-19)17-7-8-32-23(10-17)34-25(37)16-4-5-16/h3,6-14,16H,4-5H2,1-2H3,(H,33,38)(H,32,34,37) MJBAGWNMWCEEAZ-UHFFFAOYSA-N 746018 US12319655, Example 500 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746018&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929415 518808348 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533943 Cc1ccc(NC(=O)c2ccc(C(F)(F)F)cc2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C29H23F3N4O2/c1-17-2-9-23(35-27(37)19-5-7-22(8-6-19)29(30,31)32)16-24(17)20-10-12-33-25(14-20)21-11-13-34-26(15-21)36-28(38)18-3-4-18/h2,5-16,18H,3-4H2,1H3,(H,35,37)(H,34,36,38) SWSYMDQFTPVSEN-UHFFFAOYSA-N 746019 US12319655, Example 501 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 5500 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746019&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929274 518808349 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533947 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C29H23F3N4O2/c1-17-5-8-23(35-28(38)21-3-2-4-22(13-21)29(30,31)32)16-24(17)19-9-11-33-25(14-19)20-10-12-34-26(15-20)36-27(37)18-6-7-18/h2-5,8-16,18H,6-7H2,1H3,(H,35,38)(H,34,36,37) HFTQKGNZOVTEPQ-UHFFFAOYSA-N 746020 US12319655, Example 502 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746020&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168930227 518808350 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3 1533951 Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccc2F)cc1-c1ccnc(-c2ccnc(NC(=O)C3CC3)c2)c1 InChI=1S/C29H22F4N4O2/c1-16-2-6-21(36-28(39)23-14-20(29(31,32)33)5-7-24(23)30)15-22(16)18-8-10-34-25(12-18)19-9-11-35-26(13-19)37-27(38)17-3-4-17/h2,5-15,17H,3-4H2,1H3,(H,36,39)(H,35,37,38) WPJNLPRBDLQXMH-UHFFFAOYSA-N 746021 US12319655, Example 503 Serine/threonine-protein kinase A-Raf [273-606,Y301D,Y302D] 300 US Patent 10.7270/Q2B85DQR US12319655 Flynn, DL; Ahn, YM; Vogeti, L; Le Bourdonnec, B 6/3/2025 9/25/2025 Deciphera Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=746021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1970&target=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=746021&enzyme=Serine%2Fthreonine-protein+kinase+A-Raf+%5B273-606%2CY301D%2CY302D%5D&column=ki&startPg=0&Increment=50&submit=Search 168929397 518808351 1 KSPAEQRERKSLADDKKKVKNLGYRDSGDDWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP 9AXM Serine/threonine-protein kinase A-Raf ARAF_HUMAN P10398 P07557 Q5H9B2 Q5H9B3